thiazoles has been researched along with gw0742 in 157 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 49 (31.21) | 29.6817 |
| 2010's | 98 (62.42) | 24.3611 |
| 2020's | 10 (6.37) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, E; Fivush, A; Goreham, D; Haffner, CD; Lambert, MH; LeGrumelec, C; Maloney, PR; Montana, VG; Oliver, WR; Sierra, ML; Sternbach, DD; Sznaidman, ML; Willson, TM; Xu, HE | 1 |
| Chen, YE; Cheng, L; Ding, G; Qin, Q; Woods, D; Xiao, Y; Yang, Q | 1 |
| May, FJ; Monteith, GR; Roberts-Thomson, SJ; Robinson, JA; Smith, SA; Venkata, NG | 1 |
| Baller, JF; Chimini, G; Groen, AK; Groot, PH; Havinga, R; Kruit, JK; Kuipers, F; Lestavel, S; Staels, B; van der Veen, JN | 1 |
| Al-Khalili, L; Ehrenborg, E; Kannisto, K; Krämer, DK; Krook, A; Perrini, S; Skogsberg, J; Wallberg-Henriksson, H; Wretenberg, P; Zierath, JR | 1 |
| Cha, JY; Ge, H; Gopal, H; Harp, C; Li, C; Repa, JJ; Yu, X | 1 |
| Graham, TL; Mookherjee, C; Palmer, CN; Patel, L; Suckling, KE | 1 |
| Abbot, EL; Buchan, KW; Hassall, DG; McCormack, JG; Reynet, C; Yeaman, SJ | 1 |
| Bility, MT; Billin, AN; Gonzalez, FJ; Kim, DJ; Peters, JM; Willson, TM | 1 |
| Dello Russo, C; Feinstein, DL; Gavrilyuk, V; Kalinin, S; Peters, JM; Polak, PE; Richardson, J; Sharp, A; Weinberg, G; Willson, TM | 1 |
| Ali, FY; Bishop-Bailey, D; Desvergne, B; Egan, K; FitzGerald, GA; Mitchell, JA; Wahli, W; Warner, TD | 1 |
| Cabot, PJ; Davis, B; Monteith, GR; Roberts-Thomson, SJ; Robinson, JA; Venkata, NG | 1 |
| Finn, P | 1 |
| Al-Makdissy, N; Becuwe, P; Chedotal, A; Collet, P; Dauça, M; Devignes, MD; Domenjoud, L; Donner, M; Huin-Schohn, C; Kerjan, G; Murad, H; Schohn, H | 1 |
| Billin, AN; Gonzalez, FJ; Kennett, MJ; Marin, HE; Peraza, MA; Peters, JM; Ward, JM; Willson, TM | 1 |
| Cheng, L; Ding, G; Frontin, S; Qin, Q; Yang, Q | 1 |
| Cozzone, D; Debard, C; Disse, E; Husson, B; Laville, M; Ricard, N; Vidal, H; Vouillarmet, J | 1 |
| Bility, MT; Billin, AN; Burdick, AD; Girroir, EE; Gonzalez, FJ; Peters, JM; Willson, TM | 1 |
| Benedetti, E; Cerù, MP; Cifone, MG; Cimini, A; Cinque, B; Cristiano, L; D'Amico, MA; D'Angelo, B; Di Loreto, S; Festuccia, C | 1 |
| Adachi, M; Billin, AN; Gonzalez, FJ; Hollingshead, HE; Kennett, MJ; Morimura, K; Peters, JM; Willson, TM | 1 |
| Bennett, AJ; Constantin, D; Constantin-Teodosiu, D; Greenhaff, PL; Layfield, R; Tsintzas, K | 1 |
| Elias, PM; Feingold, KR; Jiang, YJ; Kim, P; Lu, B; Paragh, G; Schmitz, G | 1 |
| Bajwa, PJ; Carson, MJ; Cong, Y; Elson, CO; Jeske, DR; Lee, JW; Lytle, C; Straus, DS | 1 |
| Amin, S; Billin, AN; Borland, MG; Girroir, EE; Gonzalez, FJ; Hollingshead, HE; Killins, RL; Peters, JM; Sharma, AK; Willson, TM | 1 |
| Billin, AN; Borland, MG; Gonzalez, FJ; Hollingshead, HE; Peters, JM; Willson, TM | 1 |
| Billin, AN; Grillot, DA; Iannone, MA; Lazar, MA; Lobe, DC; Shearer, BG; Stanley, TB; Steger, DJ; Way, JM; Willson, TM | 1 |
| Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG | 1 |
| Chien, S; Fan, Y; Guan, Y; Qin, X; Staels, B; Tang, Z; Wang, N; Wang, X; Wang, Y; Zhang, H; Zhu, Y | 1 |
| Amin, S; Billin, AN; Girroir, EE; Gonzalez, FJ; Hollingshead, HE; Peters, JM; Robertson, GP; Sharma, AK; Willson, TM | 1 |
| Bao, W; Jucker, BM; Nerurkar, SS; Ohlstein, EH; Sarov-Blat, L; Steplewski, K; Willette, RN; Yue, TL | 1 |
| Han, CG; Liu, YX; Sheng, L; Ye, P; Zhang, ZY | 1 |
| Atkins, AR; Barish, GD; Collins, AR; Downes, M; Evans, RM; Hsueh, WA; Lee, CH; Liu, J; Lyon, CJ; Takata, Y; Tangirala, RK; Yin, F | 1 |
| Brodie, T; Cariello, NF; Casey, WM; Jordan, HL; Ni, H; Yoon, L | 1 |
| Abumrad, NA; Gaudel, C; Giordano, C; Grimaldi, PA; Schwartz, C | 1 |
| Bronfman, M; Leisewitz, AV; Loyola, G; Martinez, GR; Urrutia, CR | 1 |
| Southgate, J; Varley, CL | 1 |
| Bordelon, NR; Brodie, TA; Cummings, CA; Faiola, B; Falls, JG; Miller, RT; Peterson, RA; Romach, EH | 1 |
| Barone, FC; Barton, ME; Billin, AN; Haskova, Z; Hoang, B; Kilgore, KS; Luo, G; Morgan, LA; Shearer, BG | 1 |
| Fan, Y; Guan, Y; Qin, X; Tian, J; Wang, N; Wang, X; Xie, X; Zhu, Y | 1 |
| Amin, S; Borland, MG; Foreman, JE; Girroir, EE; Gonzalez, FJ; Peters, JM; Ross, AC; Sharma, AK; Zolfaghari, R | 1 |
| Bility, MT; Blazanin, N; Devlin-Durante, MK; Glick, AB; Gonzalez, FJ; Kang, BH; Kennett, MJ; Peters, JM; Ward, JM | 1 |
| Baker, DJ; Constantin, D; Constantin-Teodosiu, D; Greenhaff, PL | 1 |
| Li, Y; Liu, J; Luo, J; Wang, P; Wu, S; Yang, Q; Yin, R; Zhelyabovska, O | 1 |
| Giordano, C; Gounon, P; Grimaldi, P; Hatem, SN; Jehl-Piétri, C; Lopez, P; Murdaca, J; Schwartz, C; Wagner, KD; Wagner, N | 1 |
| Gaudel, C; Giordano, C; Grimaldi, PA; Jehl-Piétri, C; Lopez, P; Murdaca, J; Rousseau, AS; Sibille, B; Wagner, N | 1 |
| Groen, AK; Huet, S; Kuipers, F; Levels, JH; Oude Elferink, RP; van den Oever, K; van der Velde, AE; Vrins, CL | 1 |
| Eder, K; Gutgesell, A; Koch, A; König, B; Ringseis, R; Spielmann, J; Stangl, GI; Wen, G | 1 |
| Amin, S; Foreman, JE; Gonzalez, FJ; Peters, JM; Sharma, AK | 1 |
| Barish, G; Crumrine, D; Elias, PM; Evans, RM; Feingold, KR; Jiang, YJ; Lu, B; Schmuth, M | 1 |
| Bility, MT; Gonzalez, FJ; Kang, BH; Peters, JM; Zhu, B | 1 |
| Awakuni, JU; Chawla, A; Dunn, SE; Eagle, AR; Goh, YP; Heredia, JE; Michie, SA; Morel, CR; Mukundan, L; Mwangi, JW; Nguyen, KD; Odegaard, JI; Ricardo-Gonzalez, RR; Steinman, L | 1 |
| Duarte, J; Galindo, P; Gómez-Guzmán, M; Haro, JM; Jiménez, R; López-Sepúlveda, R; Pérez-Vizcaíno, F; Quintela, AM; Romero, M; Sánchez, M; Zarzuelo, A; Zarzuelo, MJ | 1 |
| Castiglia, S; Collino, M; Fantozzi, R; Kapoor, A; Thiemermann, C | 1 |
| Boullerne, AI; Feinstein, DL; Peters, JM; Polak, PE; Richardson, JC; Vittoria Simonini, M | 1 |
| Billheimer, J; Briand, F; Fuki, I; Macphee, C; Millar, JS; Naik, SU; Rader, DJ; Rothblat, G; Walker, M | 1 |
| Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Galuppo, M; Kapoor, A; Mazzon, E; Paterniti, I; Thiemermann, C | 1 |
| Desvergne, B; Garland, C; Harrington, LS; Mitchell, JA; Moreno, L; Reed, A; Wort, SJ; Zhao, L | 1 |
| Crisafulli, C; Cuzzocrea, S; Di Paola, R; Esposito, E; Galuppo, M; Genovese, T; Mazzon, E; Paterniti, I; Thiemermann, C | 1 |
| Cuzzocrea, S; Di Paola, R; Esposito, E; Galuppo, M; Mazzon, E; Paterniti, I | 1 |
| Amin, S; Anderson, CR; Borland, MG; Ferry, CH; Gonzalez, FJ; Lee, C; Müller, R; Murray, IA; Naruhn, S; Palkar, PS; Perdew, GH; Peters, JM; Sharma, AK; Sk, UH | 1 |
| Axtell, R; Bhat, R; Chawla, A; Dugas, JC; Dunn, SE; Johnson, A; Moshkova, M; Mukundan, L; Nguyen, K; Sobel, RA; Steinman, L; Straus, DS | 1 |
| Bahrami, S; Bishop-Bailey, D; Busch, D; Castiglia, S; Collino, M; Desvergne, B; Fantozzi, R; Kapoor, A; Mitchell, JA; Mota-Filipe, H; Osuchowski, MF; Patel, NS; Sepodes, B; Shintani, Y; Suzuki, K; Thiemermann, C; Yaqoob, MM | 1 |
| Cook, JA; Denenberg, A; Fan, H; Hake, PW; O'Connor, M; Piraino, G; Zingarelli, B | 1 |
| Aragno, M; Benetti, E; Castiglia, S; Collino, M; Fantozzi, R; Miglio, G; Rosa, AC; Thiemermann, C | 1 |
| Bai, R; Gonzalez, FJ; Kang, BH; Kennett, MJ; Peters, JM; Zhu, B | 1 |
| Makino, H; Matsushita, Y; Ogawa, D; Sato, C; Shikata, K; Tachibana, H; Toyota, N; Wada, J; Yamamoto, N | 1 |
| Bouchaert, E; Grillot, D; Gross, B; Hennuyer, N; Mezdour, H; Rommens, C; Staels, B | 1 |
| Bramanti, P; Cuzzocrea, S; Esposito, E; Meli, R; Paterniti, I | 1 |
| Decsi, T; Liebisch, G; Marosvölgyi, T; Mihály, J; Rühl, R; Schmitz, G; Weiss, K | 1 |
| Grimaldi, PA; Lendoye, E; Lopez, P; Murdaca, J; Rousseau, AS; Sibille, B | 1 |
| Bailón, E; Duarte, J; Galindo, P; Gálvez, J; Gómez-Guzmán, M; Jiménez, R; López-Sepúlveda, R; Nieto, A; Pérez-Vizcaíno, F; Quintela, AM; Rodríguez-Gómez, I; Romero, M; Sánchez, M; Tamargo, J; Zarzuelo, A; Zarzuelo, MJ | 1 |
| Briguglio, F; Cordasco, G; Cuzzocrea, S; Di Paola, R; Mazzon, E; Militi, D; Oteri, G; Paterniti, I | 1 |
| Bramanti, P; Cappellani, A; Cuzzocrea, S; Esposito, E; Galuppo, M; Impellizzeri, D; Mazzon, E; Paterniti, I; Riccardi, L | 1 |
| Camussi, G; Fantozzi, R; Grange, C; Miglio, G; Rattazzi, L; Rosa, AC | 1 |
| Batista, FA; Bernardes, A; Figueira, AC; Gratieri, J; Oliveira, PS; Polikarpov, I; Trivella, DB; Webb, P | 1 |
| Cogolludo, A; Duarte, J; Galindo, P; Gómez-Guzmán, M; Jiménez, R; Pérez-Vizcaíno, F; Quintela, AM; Sánchez, M; Tamargo, J; Vargas, F; Zarzuelo, MJ | 1 |
| Cho, EJ; Choi, R; Choi, YS; Chung, CH; Kim, BH; Kim, HM; Lee, EY; Lee, MY; Naowaboot, J; Shin, JY; Shin, YG; Yang, YC | 1 |
| Choi, R; Chung, CH; Hyun, M; Kim, GT; Kim, S; Lee, EY; Lee, MY; Seok, S | 1 |
| Benedict, G; Bhat, S; Ebraheim, NA; Heck, BE; Kim, DH; Lecka-Czernik, B; Liu, J; Peterson, SJ | 1 |
| Dikunets, M; Rodchenkov, G; Sobolevsky, T; Sukhanova, I; Virus, E | 1 |
| Huang, X; Liang, P; Zuo, C | 1 |
| Aragno, M; Benetti, E; Collino, M; Fantozzi, R; Mastrocola, R; Rogazzo, M; Thiemermann, C; Yaqoob, MM | 1 |
| Greene-Schloesser, D; Hsu, FC; Kooshki, M; Payne, VS; Robbins, ME; Schnegg, CI | 1 |
| Evans, RM; Martin, HL; Mounsey, RB; Mustafa, S; Nelson, MC; Sathe, K; Teismann, P | 1 |
| Alamdari, N; Aversa, Z; Castillero, E; Gurav, A; Hasselgren, PO | 1 |
| Arnold, LA; Ayers, SD; Baranowski, AM; Bikle, DD; Feleke, B; Jadhav, A; Kevin, C; Maloney, D; McCallum, MM; Nandhikonda, P; Pawlak, AJ; Rai, G; Sidhu, PS; Simeonov, A; Teske, K; Webb, P; Yasgar, A; Yuan, NY | 1 |
| Capozzi, ME; McCollum, GW; Penn, JS; Savage, SR | 1 |
| Chen, LJ; Chen, ZC; Cheng, JT; Lee, KS; Niu, HS; Wang, LY | 1 |
| Duarte, J; Gómez-Guzmán, M; Jiménez, R; Pérez-Vizcaíno, F; Quintela, AM; Romero, M; Sánchez, M; Tamargo, J; Zarzuelo, A; Zarzuelo, MJ | 1 |
| Chen, LJ; Cheng, JT; Ku, PM; Kuo, SC; Niu, HS | 1 |
| Aragno, M; Benetti, E; Chiazza, F; Collino, M; Fantozzi, R; Mastrocola, R; Minetto, MA; Rogazzo, M | 1 |
| Hamaya, R; Hirata, Y; Isobe, M; Kobayashi, N; Komuro, I; Nagai, R; Ogawa, M; Suzuki, J | 1 |
| Bulun, SE; Chakravarti, D; Coon, JS; Dyson, MT; Kim, JJ; Ma, JJ; Malpani, S; Monsivais, D; Ono, M; Pavone, ME; Xin, H; Zhao, H | 1 |
| Cigorraga, SB; Galardo, MN; Meroni, SB; Pellizzari, EH; Regueira, M; Riera, MF | 1 |
| Blokland, M; Bovee, TF; Essers, ML; Hamers, AR; Heskamp, HH; Kersten, S; Nielen, MW; van Ginkel, LA | 1 |
| Byagowi, S; Darabi, M; Fayezi, S; Mirshahvaladi, S; Sahmani, M | 1 |
| Chao, Y; Wang, HJ; Xiao, GF; Xie, LD; Xu, CS; Xu, SH | 1 |
| Bao, XC; Fang, YQ; Ma, J; You, P; Zhang, S | 2 |
| Damre, MV; Das, NR; Gangwal, RP; Sangamwar, AT; Sharma, SS | 1 |
| Casadesus, G; Kunos, G; Levi, L; Noy, N; Yu, S | 1 |
| Chang, CK; Chen, LJ; Cherng, YG; Lin, JW; Niu, CS; Niu, HS | 1 |
| Chao, X; Dong, W; Fei, Z; Han, F; Han, H; Liu, W; Ma, Y; Ning, W; Qu, Y; Wang, R; Xiong, C | 1 |
| Bain, JR; Greenberg, AS; Huang, LS; Jump, DB; Lytle, KA; Newgard, CB; Stevens, RD; Tripathy, S | 1 |
| Galatou, E; Kelly, T; Lazou, A | 1 |
| Huang, M; Song, H; Wang, K; Xie, L; Xu, C; Xu, S | 1 |
| Benavidez, JM; Black, M; Blednov, YA; Edenberg, HJ; Ferguson, LB; Foroud, T; Goate, AM; Harris, RA; Hesselbrock, V; Schoenhard, GL; Wetherill, L | 1 |
| Byagowi, S; Darabi, M; Fayezi, S; Mirshahvaladi, S; Najafipour, R; Naserpour Farivar, T; Sahmani, M | 1 |
| Donovan, LJ; Landreth, GE; Malm, T; Mariani, M; Neilson, L | 1 |
| Blanco-Vaca, F; Cedó, L; Chehaibi, K; Escolà-Gil, JC; Jauhiainen, M; Julve, J; Metso, J; Naceur Slimane, M; Palomer, X; Quesada, H; Santos, D; Vázquez-Carrera, M; Wahli, W | 1 |
| Goduni, E; Jay, T; Lamb, BT; Landreth, GE; Malm, T; Mariani, MM; Quigley, C; Ransohoff, RM; Savage, JC | 1 |
| Beniwal, M; Grewal, AS; Lather, V; Pandita, D; Sekhon, BS | 1 |
| Cogolludo, Á; Duarte, J; Gálvez, J; Gómez-Guzmán, M; Hermenegildo, C; Jiménez, R; Pérez-Vizcaíno, F; Romero, M; Toral, M; Utrilla, MP; Zarzuelo, MJ | 1 |
| Antonosante, A; Benedetti, E; Cifone, MG; Cimini, A; Cinque, B; Cristiano, L; D'Angelo, B; d'Angelo, M; Di Loreto, S; Fidoamore, A; Giordano, A; Golini, R; Ippoliti, R | 1 |
| Barroso, E; Briones, AM; Cogolludo, Á; Duarte, J; García-Redondo, AB; Gómez-Guzmán, M; Jiménez, R; Mahmoud, AM; Pérez-Vizcaíno, F; Romero, M; Sánchez, M; Toral, M; Vázquez-Carrera, M | 1 |
| Alam, M; Barson, JR; Karatayev, O; Leibowitz, SF; Poon, K | 1 |
| An, YQ; Hong, H; Hu, M; Hu, QH; Ji, MJ; Kong, LY; Long, Y; Mei, ZL; Miao, MX; Sun, HB; Tang, SS; Yu, XB | 1 |
| Cheng, JT; Ku, PM; Lee, KS; Niu, CS; Niu, HS | 1 |
| Mackenzie, LS; Patel, P; Perez Diaz, N; Zloh, M | 1 |
| Bae, GU; Go, GY; Kang, JS; Kim, YK; Lee, SJ; Seo, DW; Yoo, M | 1 |
| Ahn, JH; Hwang, JY; Hwang, SJ; Jeong, YH; Jung, MH; Kim, JH; Koh, JS; Kwak, CH; Lee, YS; Park, JR; Park, Y; Seo, HG | 1 |
| An, YQ; Du, Y; Hong, H; Hu, M; Long, Y; Sun, HB; Tang, SS; Zhang, CT; Zhang, M | 1 |
| Ihling, CH; Schwarz, R; Sinz, A; Tänzler, D | 1 |
| Fujitani, M; Fushiki, T; Inoue, K; Manio, MC; Matsumura, S | 1 |
| Abe, K; Akita, T; Horiguchi, M; Motomura, T; Oiso, Y; Ozawa, C; Yamashita, C | 1 |
| Duarte, J; Jiménez, R; Martínez, MC; Pérez-Vizcaíno, F; Robles-Vera, I; Romero, M; Tamargo, J; Toral, M | 1 |
| Dessy, C; Duarte, J; Gómez-Gúzman, M; Jiménez, R; León-Gómez, E; Pérez-Vizcaíno, F; Rath, G; Rodríguez-Gómez, I; Romero, M; Sánchez, M; Tamargo, J; Toral, M; Zarzuelo, MJ | 1 |
| Barreira, B; Briones, AM; Callejo, M; Cogolludo, A; Cortijo, J; Duarte, J; Mondejar-Parreño, G; Moral-Sanz, J; Morales-Cano, D; Moreno, L; Pandolfi, R; Perez-Vizcaino, F; Salaices, M | 1 |
| Balandaram, G; Gonzalez, FJ; Kang, BH; Kramer, LR; Murray, IA; Perdew, GH; Peters, JM | 1 |
| Agarwal, AK; Garg, A; Sankella, S | 1 |
| Cao, LL; Ji, J; Sun, XL; Yang, DD; Zeng, XN; Zhang, L; Zhao, Z | 1 |
| Blanco-Vaca, F; Bradoni, S; Chehaibi, K; Escola, JC; le Maire, L; Slimane, MN | 1 |
| Duarte, J; Jiménez, R; Pérez-Vizcaíno, F; Romero, M; Toral, M | 1 |
| Grimaldi, PA; Mothe-Satney, I; Murdaca, J; Neels, JG; Piquet, J; Rousseau, AS; Sibille, B | 1 |
| Lione, LA; Mackenzie, LS; Oweis, N; Perez-Diaz, N; Pushkarsky, I | 1 |
| Duarte, J; Gálvez, J; Jiménez, R; O'Valle, F; Pérez-Vizcaino, F; Robles-Vera, I; Rodriguez-Nogales, A; Romero, M; Sánchez, M; Toral, M | 1 |
| Arnold, LA; Feleke, B; Jadhav, A; Maloney, DJ; Nandhikonda, P; Rai, G; Sidhu, PS; Simeonov, A; Teske, KA; Yasgar, A | 1 |
| Busch, D; Hildebrand, F; Pape, HC; Pfeifer, R; Qiao, Z; Teuben, M; van Griensven, M; Yin, L | 1 |
| Duarte, J; Jiménez, R; Robles-Vera, I; Romero, M; Sabio, JM; Salaices, M; Sánchez, M; Toral, M | 1 |
| Arnold, LA; Bogart, JW; Teske, KA | 1 |
| de Oliveira, L; Graus-Nunes, F; Mandarim-de-Lacerda, CA; Rachid, TL; Silva-Veiga, FM; Souza-Mello, V | 1 |
| Bahrami, S; Busch, D; Hildebrand, F; Kapoor, A; Osuchowski, MF; Rademann, P; Thiemermann, C | 1 |
| Doycheva, DM; Enkhjargal, B; Gamdzyk, M; Malaguit, J; Tang, J; Zhang, JH | 1 |
| Chang, WT; Chen, ZC; Cheng, JT; Cheng, KC; Cheng, YZ; Li, Y | 1 |
| Belaya, I; Goldsteins, G; Grubman, A; Gureviciene, I; Huuskonen, MT; Kanninen, KM; Keuters, M; Koistinaho, J; Konttinen, H; Korhonen, P; Lampinen, R; Landreth, G; Loppi, S; Malm, T; Oksanen, M; Tanila, H | 1 |
| Chinetti, G; Le Garf, S; Le Menn, G; Mothe-Satney, I; Murdaca, J; Neels, JG; Rousseau, AS; Sibille, B | 1 |
| Du, S; Leccia, N; Martin, L; Michiels, JF; Wagner, KD; Wagner, N | 1 |
| Chen, H; Liang, J; Lu, Y; Tang, X; Wang, X; Wang, Y; Xu, J; Yan, K; Zhang, X | 1 |
| Hao, L; Li, X; Liu, F; Lv, S; Peng, Q; Wei, G; Xu, W | 1 |
| Board, M; Carr, C; Faulkner, A; Jones, C; Lopez, C; Lynam, E; Purcell, R; Wagner, KD; Wagner, N; Wheeler-Jones, C | 1 |
| Berga, SL; Man, M; Rajakumar, A; Sidell, N; Taylor, RN; Yu, J; Zou, W | 1 |
| Doycheva, DM; Gamdzyk, M; Kang, R; Tang, H; Tang, J; Travis, ZD; Zhang, JH | 1 |
| Imamoto, T; Iwano, M; Kamiyama, K; Kasuno, K; Kimura, H; Kobayashi, M; Mikami, D; Shan, J; Sugaya, T; Takahashi, N; Takeda, I; Yokoi, S | 1 |
| Andy, D; Erhardt, PW; Farris, JT; Heck, B; Heck, BE; Kim, DH; Kress, BJ; Mayo, JR; Sarver, JG; Trendel, JA | 1 |
| Galatou, E; Lazou, A; Panagiotidis, GD; Papatheodorou, I; Ravingerová, T | 1 |
| Baudoin, E; Chinetti, G; Lamghari, N; Le Garf, S; Le Menn, G; Lepouse, D; Moratal, C; Mothe-Satney, I; Murdaca, J; Neels, JG; Rousseau, AS; Sibille, B | 1 |
| Cai, Z; Dong, Y; Ji, J; Jiang, Z; Li, S; Sun, X; Sun, Y; Yu, J | 1 |
2 review(s) available for thiazoles and gw0742
| Article | Year |
|---|---|
Recent Updates on Peroxisome Proliferator-Activated Receptor δ Agonists for the Treatment of Metabolic Syndrome.
Topics: Animals; Humans; Metabolic Syndrome; PPAR delta; Thiazoles | 2016 |
Antihypertensive effects of peroxisome proliferator-activated receptor-β/δ activation.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Endothelium, Vascular; Fatty Acids; Gene Expression Regulation; Humans; Hypertension; Inflammation; Phenoxyacetates; PPAR delta; PPAR-beta; Rats; Rats, Inbred SHR; RGS Proteins; Sympathetic Nervous System; Thiazoles; Vasoconstriction; Vasodilation | 2017 |
155 other study(ies) available for thiazoles and gw0742
| Article | Year |
|---|---|
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.
Topics: Animals; Cells, Cultured; Combinatorial Chemistry Techniques; Humans; Mice; Radioligand Assay; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Thiazoles; Transcription Factors; Transcriptional Activation | 2003 |
Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes.
Topics: Animals; Animals, Newborn; Cells, Cultured; DNA Primers; Fatty Acids; Gene Expression; Humans; Mice; Mice, Knockout; Myocytes, Cardiac; Oxidation-Reduction; Palmitates; Protein Isoforms; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors; Transcriptional Activation | 2004 |
Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons.
Topics: Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebellum; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Neurotoxins; Potassium Deficiency; Proto-Oncogene Proteins c-jun; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Transcription Factors | 2004 |
Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Caco-2 Cells; Cholesterol; Cholesterol, HDL; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Macrophages; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred DBA; Mice, Knockout; PPAR delta; Proteins; RNA, Messenger; Sterols; Thiazoles; Time Factors | 2005 |
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.
Topics: Adipocytes; Animals; Biological Transport; Cell Line; Cells, Cultured; Fibroblasts; Flavonoids; Gene Expression Regulation; Glucose; Humans; Imidazoles; MAP Kinase Kinase Kinases; Muscle Fibers, Skeletal; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; PPAR delta; Pyridines; Thiazoles | 2005 |
Differential regulation and properties of angiopoietin-like proteins 3 and 4.
Topics: Angiopoietin-Like Protein 3; Angiopoietin-Like Protein 4; Angiopoietin-like Proteins; Angiopoietins; Animals; Blood Proteins; Fenofibrate; Food Deprivation; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins; Lipoprotein Lipase; Male; Mice; Pioglitazone; PPAR alpha; PPAR delta; PPAR gamma; Protein Structure, Quaternary; Thiazoles; Thiazolidinediones | 2005 |
The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice.
Topics: Animals; Aorta; Arteriosclerosis; Biomarkers; Body Weight; Eating; Inflammation; Lipids; Lipoproteins; Macrophages; Mice; Mice, Knockout; PPAR delta; Receptors, LDL; Thiazoles | 2005 |
Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.
Topics: Butyrates; Cells, Cultured; Fatty Acids; Gene Expression Regulation, Enzymologic; Glucose; Humans; Insulin; Isoenzymes; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts, Skeletal; Oxazoles; Phenylurea Compounds; PPAR alpha; PPAR delta; PPAR gamma; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA, Messenger; Thiazoles; Tyrosine | 2005 |
PPARbeta/delta selectively induces differentiation and inhibits cell proliferation.
Topics: Animals; Calcium; Calcium Signaling; Cell Differentiation; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; In Vitro Techniques; Keratinocytes; Ligands; Mice; Mice, Knockout; Models, Biological; Peroxidase; PPAR-beta; Tetradecanoylphorbol Acetate; Thiazoles | 2006 |
Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis.
Topics: Animals; Brain; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Enzymologic; Glycoproteins; Immunohistochemistry; Interferon-gamma; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin-Oligodendrocyte Glycoprotein; Neuroglia; Peptide Fragments; PPAR delta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Thiazoles; Time Factors | 2005 |
Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts.
Topics: Animals; Cell Proliferation; Cells, Cultured; Epoprostenol; Fibroblasts; Ligands; Lung; Mice; Mice, Mutant Strains; PPAR gamma; PPAR-beta; Receptors, Epoprostenol; Receptors, Prostaglandin; Thiazoles | 2006 |
Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.
Topics: Breast Neoplasms; Butyrates; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Female; Humans; Phenylurea Compounds; Phthalic Acids; Plasticizers; PPAR alpha; PPAR gamma; PPAR-beta; Statistics, Nonparametric; Thiazoles; Thiazolidinediones; Transfection | 2006 |
American Heart Association--scientific sessions 2005. Potential new drugs for various indications. 13-16 November 2005, Dallas, TX, USA.
Topics: American Heart Association; Animals; Cardiotonic Agents; Heart Diseases; Humans; Piperidines; Potassium Channel Blockers; PPAR delta; Pyrazoles; Rimonabant; Thiazoles | 2006 |
Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.
Topics: Alitretinoin; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromans; Dimerization; Fenofibrate; Gene Expression; HT29 Cells; Humans; K562 Cells; PPAR alpha; PPAR gamma; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Semaphorins; Thiazoles; Thiazolidinediones; Tretinoin; Troglitazone | 2006 |
Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis.
Topics: Animals; Azoxymethane; Cathepsin E; Colonic Neoplasms; Fatty Acid-Binding Proteins; Ligands; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Perilipin-2; PPAR-beta; RNA, Messenger; Thiazoles | 2006 |
PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media; Gene Expression Regulation; Heart; I-kappa B Kinase; Inflammation; Ligands; Lipopolysaccharides; Mice; Myocytes, Cardiac; NF-kappa B; PPAR delta; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Thiazoles; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2006 |
Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patients.
Topics: Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glycogen; Humans; Insulin; Male; Middle Aged; Muscle Cells; Oxidation-Reduction; Palmitic Acid; Phosphorylation; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Thiazoles; Time Factors | 2006 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Proliferation; Gene Expression Regulation; Humans; Keratinocytes; Ligands; MAP Kinase Signaling System; Mice; PPAR delta; PPAR-beta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA, Messenger; Telomerase; Thiazoles; Transcriptional Activation; Ultraviolet Rays | 2007 |
PPARbeta agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y.
Topics: Brain-Derived Neurotrophic Factor; Cell Adhesion; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Movement; Gene Expression; Humans; Neurites; Neuroblastoma; Oleic Acid; Peripheral Nervous System Neoplasms; PPAR-beta; Receptor, trkB; RNA, Small Interfering; Thiazoles | 2007 |
PPARbeta/delta protects against experimental colitis through a ligand-independent mechanism.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Disease Progression; Enterocytes; Female; Gene Expression; Interferon-gamma; Interleukin-6; Ligands; Mice; Mice, Inbred C57BL; Peroxidase; Plasma Substitutes; Polymerase Chain Reaction; PPAR delta; PPAR-beta; RNA, Messenger; Severity of Illness Index; Thiazoles; Tumor Necrosis Factor-alpha | 2007 |
PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Creatine; DNA; Energy Metabolism; Lactates; Male; Mitochondria, Muscle; Muscle, Skeletal; Muscular Atrophy; PPAR delta; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Thiazoles | 2007 |
PPAR and LXR activators regulate ABCA12 expression in human keratinocytes.
Topics: ATP-Binding Cassette Transporters; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epidermis; Gene Expression Regulation; Humans; Keratinocytes; Liver X Receptors; Orphan Nuclear Receptors; Permeability; Peroxisome Proliferator-Activated Receptors; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones | 2008 |
Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.
Topics: Age Factors; Animals; Cell Count; Chemokine CXCL10; Chemokines, CXC; Colitis; Crohn Disease; Disease Models, Animal; Fenofibrate; Gene Expression; HT29 Cells; Humans; Hypolipidemic Agents; Interferon-gamma; Interleukin-10; Interleukin-17; Mice; Mice, Inbred C3H; Mice, Knockout; PPAR alpha; Spleen; Th1 Cells; Thiazoles | 2007 |
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Polyps; Culture Media, Serum-Free; Cyclooxygenase 2; Humans; Ligands; Liver; Mice; Mice, Inbred C57BL; Phosphorylation; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Thiazoles; Vascular Endothelial Growth Factor A | 2007 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms.
Topics: Animals; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Ligands; Mice; Mice, Knockout; PPAR delta; PPAR-beta; Signal Transduction; Sulfonamides; Thiazoles | 2008 |
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.
Topics: Cells, Cultured; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Fatty Acids; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Humans; Ligands; Molecular Structure; Muscle, Skeletal; Oxidation-Reduction; PPAR delta; PPAR-beta; Sulfones; Thiazoles; Thiophenes | 2008 |
PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Breast Neoplasms; Cell Line, Tumor; Cyanamide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Female; Fomepizole; Gene Expression Regulation, Neoplastic; Humans; PPAR alpha; PPAR-beta; Pyrazoles; RNA, Messenger; Thiazoles; Transcription, Genetic; Transcriptional Activation; Transfection | 2008 |
Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells.
Topics: Catalase; Cells, Cultured; Endothelial Cells; Humans; Inflammation; Ligands; PPAR delta; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Thioredoxins; Umbilical Veins; Up-Regulation | 2008 |
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.
Topics: Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Gene Expression; Humans; Ligands; PPAR delta; PPAR-beta; Thiazoles; Time Factors | 2008 |
In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Cytokines; Disease Models, Animal; Fatty Acids; Heart; Ketones; Male; Metabolic Syndrome; Myocardial Reperfusion Injury; PPAR delta; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; RNA, Messenger; Thiazoles; Troponin I | 2008 |
Peroxisome proliferator-activated receptor beta/delta activation improves angiotensin II-induced cardiac hypertrophy in vitro.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Membrane; Cells, Cultured; Cytokines; Down-Regulation; Fluorescent Antibody Technique; In Vitro Techniques; Leucine; Myocytes, Cardiac; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staining and Labeling; Thiazoles | 2008 |
PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis.
Topics: Adipokines; Angiotensin II; Animals; Atherosclerosis; Cell Movement; Enzyme Activation; Gene Expression Regulation; Hypercholesterolemia; Hypertriglyceridemia; Inflammation; Ligands; Macrophages; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; PPAR delta; Proto-Oncogene Proteins c-bcl-6; Receptors, LDL; Signal Transduction; Thiazoles; Transcription, Genetic | 2008 |
Correlation analysis of gene expression and clinical chemistry to identify biomarkers of skeletal myopathy in mice treated with PPAR agonist GW610742X.
Topics: Animals; Biomarkers; Creatine Kinase; Female; Gene Expression; Gene Expression Profiling; Male; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferator-Activated Receptors; ras Proteins; Rats; Rats, Sprague-Dawley; Repressor Proteins; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thiazoles | 2008 |
Pharmacological activation of PPARbeta promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Fibers, Skeletal; Muscle, Skeletal; MyoD Protein; Myogenic Regulatory Factor 5; Neovascularization, Physiologic; Physical Conditioning, Animal; PPAR-beta; Succinate Dehydrogenase; Thiazoles | 2008 |
A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis.
Topics: Alkyl and Aryl Transferases; Animals; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Enzyme Induction; Glioma; Lipid Metabolism; Mice; Myelin Sheath; Oligodendroglia; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; PPAR-beta; Pyrimidines; Rats; Receptor Cross-Talk; RNA Interference; RNA, Small Interfering; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Transcription, Genetic; Transfection | 2008 |
Effects of PPAR agonists on proliferation and differentiation in human urothelium.
Topics: Cell Death; Cell Differentiation; Cell Proliferation; Cells, Cultured; ErbB Receptors; Fenofibrate; Gene Expression Regulation; Humans; Hydrazines; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Signal Transduction; Thiazoles; Urothelium | 2008 |
PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742.
Topics: Animals; Dose-Response Relationship, Drug; Hepatomegaly; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Muscular Diseases; Organ Size; Peroxisomes; PPAR alpha; PPAR delta; Pyrimidines; Thiazoles | 2008 |
Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARbeta/delta ligand GW0742.
Topics: Animals; Cytokines; Granulocyte-Macrophage Colony-Stimulating Factor; Inflammation; Leukocytes; Ligands; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Models, Biological; Neutrophils; PPAR delta; PPAR-beta; Thiazoles | 2008 |
Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice.
Topics: Animals; Cell Line, Tumor; Diabetes Complications; Diabetes Mellitus; Hepatocytes; Humans; Lipogenesis; Liver; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Peroxisome Proliferators; PPAR delta; Response Elements; RNA, Small Interfering; Sterol Regulatory Element Binding Protein 1; Thiazoles; Transfection | 2008 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes.
Topics: Annexin A5; Blotting, Western; Caspase 3; Caspase 7; Cell Line; Cell Proliferation; Flow Cytometry; Humans; Keratinocytes; Ligands; Phosphorylation; Polymerase Chain Reaction; PPAR delta; PPAR-beta; Thiazoles; Tretinoin | 2008 |
Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) inhibits chemically induced skin tumorigenesis.
Topics: Acetone; Animals; Carcinogens; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Enzyme Activation; Female; Keratinocytes; Ligands; Mice; Mice, Mutant Strains; PPAR delta; PPAR-beta; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiazoles | 2008 |
PPARdelta agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction.
Topics: Adenosine Triphosphate; Animals; Carbohydrate Metabolism; Electric Stimulation; Glucose; Lactic Acid; Male; Mitochondria, Muscle; Muscle Contraction; Muscle, Skeletal; Oxidation-Reduction; PPAR delta; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Thiazoles | 2009 |
Peroxisome proliferator-activated receptor delta regulates mitofusin 2 expression in the heart.
Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Electrophoretic Mobility Shift Assay; Fasting; Gene Expression Regulation; GTP Phosphohydrolases; Membrane Proteins; Mice; Mice, Knockout; Mitochondrial Proteins; Myocytes, Cardiac; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polymerase Chain Reaction; PPAR delta; Promoter Regions, Genetic; Rats; Thiazoles; Trans-Activators; Transcription Factors | 2009 |
Peroxisome proliferator-activated receptor beta stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cells, Cultured; Coronary Vessels; Cyclin-Dependent Kinase 9; Cyclosporine; Enzyme Inhibitors; Heart; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardium; Myocytes, Cardiac; Neovascularization, Physiologic; NFATC Transcription Factors; PPAR-beta; Thiazoles | 2009 |
Peroxisome proliferator-activated receptor beta activation promotes myonuclear accretion in skeletal muscle of adult and aged mice.
Topics: Aging; Animals; Calcineurin; Calcineurin Inhibitors; Cell Division; Cell Fusion; Cell Nucleus; Citrate (si)-Synthase; Cyclosporine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Muscle Fibers, Fast-Twitch; Muscle Fibers, Skeletal; Muscle, Skeletal; NFATC Transcription Factors; PPAR-beta; Proliferating Cell Nuclear Antigen; Satellite Cells, Skeletal Muscle; Succinate Dehydrogenase; Thiazoles | 2009 |
Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux.
Topics: Animals; Biological Transport; Cholesterol; Eating; Intestinal Mucosa; Intestines; Lipoproteins; Liver; Male; Mice; PPAR delta; RNA, Messenger; Thiazoles | 2009 |
Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells.
Topics: Animals; Base Sequence; Body Weight; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Fasting; Female; Gene Expression Regulation, Enzymologic; Humans; Liver; Luciferases; Male; Mice; Mice, Knockout; Molecular Sequence Data; Mutation; PPAR alpha; PPAR delta; Promoter Regions, Genetic; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transcription, Genetic | 2009 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Dose-Response Relationship, Drug; Female; Humans; Ligands; Mammary Neoplasms, Animal; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; PPAR delta; PPAR-beta; Thiazoles; Time Factors; Tumor Stem Cell Assay | 2010 |
PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation.
Topics: Animals; Cell Differentiation; Enzyme Activation; Epidermis; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Mice; Mice, Knockout; Permeability; PPAR delta; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors | 2010 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Female; Keratinocytes; Keratins; Keratoacanthoma; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Papilloma; PPAR delta; PPAR-beta; RNA, Messenger; Skin Neoplasms; Sulfonamides; Thiazoles; Time Factors | 2010 |
PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.
Topics: Animals; Apoptosis; Autoantibodies; Autoimmune Diseases; Autoimmunity; CD11b Antigen; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fluoresceins; Gene Expression Regulation; Humans; Hyaluronan Receptors; Immune Tolerance; Macrophages; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitochondrial Proteins; Opsonin Proteins; Phagocytosis; PPAR delta; Promoter Regions, Genetic; RNA, Messenger; Thiazoles; Thymus Gland; Time Factors | 2009 |
Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.
Topics: Anilides; Animals; Aorta; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; Morpholines; Nitric Oxide; Nitric Oxide Synthase Type III; Phenoxyacetates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Umbilical Veins; Vasodilation | 2010 |
Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat.
Topics: Animals; Cyclooxygenase 2; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hemodynamics; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Oxazoles; Phosphorylation; PPAR alpha; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Thiazoles; Tyrosine | 2010 |
Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins.
Topics: Animals; Bone Morphogenetic Proteins; Carrier Proteins; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligodendroglia; Pioglitazone; PPAR delta; Stem Cells; Thiazoles; Thiazolidinediones | 2010 |
Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol.
Topics: Animals; Azetidines; Biological Transport; Cholesterol, HDL; Chromatography, High Pressure Liquid; Ezetimibe; Feces; Female; Gene Expression Regulation; Intestinal Absorption; Intestinal Mucosa; Intestines; Kinetics; Liver; Macrophages; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; PPAR delta; RNA, Messenger; Thiazoles; Time Factors | 2009 |
Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury.
Topics: Animals; Apoptosis; Cytokines; Enzyme Induction; Fas Ligand Protein; Male; Mice; Neutrophil Infiltration; Nitric Oxide Synthase; Peroxidase; PPAR delta; PPAR-beta; Spinal Cord Injuries; Sulfones; Thiazoles; Thiophenes; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Cardiomegaly; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Transgenic; PPAR delta; PPAR-beta; Rats; Rats, Wistar; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Thiazoles | 2010 |
GW0742, a high-affinity PPAR -beta/delta agonist, inhibits acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Apoptosis; bcl-2-Associated X Protein; Carrageenan; I-kappa B Proteins; Lipid Peroxidation; Lung; Male; Mice; Neutrophils; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Pleurisy; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
GW0742, a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Cytokines; Down-Regulation; Inflammation; Intestinal Diseases; Mice; PPAR delta; PPAR-beta; Reperfusion Injury; Survival Rate; Thiazoles | 2010 |
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.
Topics: Animals; Cell Line; Cell Proliferation; Cells; Humans; Keratinocytes; Mice; Mice, Knockout; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; PPAR-beta; Thiazoles; Transcriptional Activation; Up-Regulation | 2010 |
Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity.
Topics: Animals; Brain; CD4-Positive T-Lymphocytes; Cell Proliferation; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Glycoproteins; Homeodomain Proteins; Humans; Interferon-gamma; Interleukin-12; Interleukin-17; Leukocytes, Mononuclear; Lipopolysaccharides; Lymphocyte Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin-Oligodendrocyte Glycoprotein; Myeloid Cells; Nuclear Receptor Subfamily 1, Group F, Member 3; Peptide Fragments; PPAR delta; Spinal Cord; T-Box Domain Proteins; T-Lymphocytes, Helper-Inducer; Th1 Cells; Thiazoles; Tumor Necrosis Factor-alpha | 2010 |
Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.
Topics: Animals; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Shock, Septic; Signal Transduction; Sulfones; Thiazoles; Thiophenes | 2010 |
Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.
Topics: Animals; Bacteremia; Blotting, Western; Cecum; Cell Nucleus; Cells, Cultured; Chromatin Immunoprecipitation; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Hypotension; Immunoenzyme Techniques; Inflammation; Luciferases; Macrophages, Peritoneal; Male; Mice; Mice, Knockout; NF-kappa B; PPAR delta; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Survival Rate; Thiazoles | 2010 |
Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats.
Topics: Animals; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; Kidney; Male; Peroxidase; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles | 2011 |
Chemoprevention of chemically induced skin tumorigenesis by ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase 2.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Differentiation; Chemoprevention; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Gene Expression Regulation, Neoplastic; Inflammation; Ligands; Mice; PPAR delta; PPAR-beta; Skin Neoplasms; Sulfonamides; Thiazoles | 2010 |
Activation of peroxisome proliferator-activated receptor delta inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice.
Topics: Albuminuria; Analysis of Variance; Animals; Blotting, Western; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fluorescent Antibody Technique; Immunoprecipitation; Kidney; Male; Mice; Osteopontin; PPAR delta; Proto-Oncogene Proteins c-bcl-6; Thiazoles | 2011 |
Generation and characterization of a humanized PPARδ mouse model.
Topics: Animals; Diet, High-Fat; DNA, Complementary; Fasting; Female; Gene Expression Profiling; Humans; Inflammation; Lipid Metabolism; Lipoproteins, HDL; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; PPAR delta; RNA, Messenger; Thiazoles | 2011 |
GW0742, a high-affinity PPAR-δ agonist, mediates protection in an organotypic model of spinal cord damage.
Topics: Animals; Mice; Models, Biological; Nerve Degeneration; Neuroprotective Agents; Organ Culture Techniques; PPAR delta; Protein Isoforms; Spinal Cord; Spinal Cord Injuries; Thiazoles | 2012 |
Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice.
Topics: Acetyltransferases; Animals; Benzoates; Butyrates; Fatty Acid Elongases; Fatty Acids; Female; Gene Expression; Hydrocarbons, Fluorinated; Liver; Liver X Receptors; Mice; Mice, Inbred C57BL; Organic Chemicals; Orphan Nuclear Receptors; Peroxisome Proliferator-Activated Receptors; Phenylurea Compounds; Phospholipids; Receptors, Retinoic Acid; Rosiglitazone; Stearoyl-CoA Desaturase; Sulfonamides; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones | 2011 |
PPARbeta activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Down-Regulation; Enzyme Activation; Male; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle, Skeletal; Physical Conditioning, Animal; PPAR-beta; Promoter Regions, Genetic; Protein Subunits; Starvation; Thiazoles; Transcription, Genetic | 2011 |
Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Caveolin 1; Disease Models, Animal; Endothelium, Vascular; GTP-Binding Proteins; Heart Rate; Hypertension; Male; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; Thiazoles | 2011 |
Emerging role of PPAR-β/δ in inflammatory process associated to experimental periodontitis.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Bone Resorption; Capillary Permeability; Cytokines; Dose-Response Relationship, Drug; Male; Neutrophil Infiltration; NF-kappa B; Nitric Oxide Synthase Type II; Periodontitis; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Thiazoles; Tyrosine | 2011 |
Peroxisome proliferator-activated receptor β/δ agonist GW0742 ameliorates cerulein- and taurocholate-induced acute pancreatitis in mice.
Topics: Acute Disease; Amylases; Animals; Cell Adhesion Molecules; Cell Movement; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Lipase; Male; Mice; Mice, Inbred Strains; Neutrophils; Pancreatitis; PPAR delta; PPAR-beta; Taurocholic Acid; Thiazoles; Time Factors | 2012 |
Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action.
Topics: Apoptosis; Cells, Cultured; Cytoprotection; Electron Transport Complex IV; Gemfibrozil; Humans; Membrane Potentials; Mitochondrial Turnover; Necrosis; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Podocytes; Thiazoles; Thiazolidinediones | 2012 |
Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Crystallography, X-Ray; Hep G2 Cells; Humans; Ligands; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; PPAR alpha; PPAR delta; PPAR gamma; Protein Conformation; Recombinant Proteins; Sequence Homology, Amino Acid; Thiazoles | 2012 |
Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelial Cells; Endothelin-1; Gene Expression; Gene Expression Regulation; In Vitro Techniques; Macrophages; NADPH Oxidases; Neutrophil Infiltration; Peroxidase; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Reactive Oxygen Species; Streptozocin; Thiazoles; Triglycerides; Vasodilation; Vasodilator Agents | 2012 |
Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Diabetes Mellitus; Fatty Liver; Glucose Tolerance Test; Hep G2 Cells; Humans; Insulin Resistance; Liver; Male; PPAR delta; Rats; Rats, Long-Evans; Thiazoles; Triglycerides | 2012 |
Peroxisome proliferator-activated receptor-δ activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes.
Topics: Albuminuria; Animals; Blotting, Western; Cell Culture Techniques; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Immunohistochemistry; Membrane Proteins; Podocytes; PPAR gamma; Rats; Rats, Inbred OLETF; Real-Time Polymerase Chain Reaction; Thiazoles | 2012 |
Peroxisome proliferator-activated receptor delta agonist attenuates nicotine suppression effect on human mesenchymal stem cell-derived osteogenesis and involves increased expression of heme oxygenase-1.
Topics: Alkaline Phosphatase; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Remodeling; Calcium; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation; Heme Oxygenase-1; Humans; Mesenchymal Stem Cells; Nicotine; Nicotinic Agonists; Osteoblasts; Osteogenesis; Osteoporosis; PPAR delta; Smoking; Thiazoles | 2013 |
Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine.
Topics: Adult; Chromatography, Liquid; Humans; Male; PPAR delta; Tandem Mass Spectrometry; Thiazoles | 2012 |
Role of PPARbeta in fibroblast response to heat injury.
Topics: Animals; Cell Survival; Fibroblasts; Gene Expression Regulation; Gene Knockdown Techniques; Hot Temperature; Mice; PPAR-beta; RNA, Small Interfering; Skin; Thiazoles; Wound Healing | 2012 |
Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation.
Topics: Animals; Carrier Proteins; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dietary Carbohydrates; Disease Models, Animal; Fructokinases; Fructose; Glucose; Hypoglycemic Agents; Inflammasomes; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; PPAR gamma; Seeds; Thiazoles; Zea mays | 2013 |
The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation.
Topics: Animals; Cognition Disorders; Cranial Irradiation; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Inflammation; Interleukin-1beta; Mice; Mice, Inbred C57BL; Microglia; Neurogenesis; Phosphorylation; PPAR delta; Thiazoles | 2013 |
A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Count; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Female; Glial Fibrillary Acidic Protein; Humans; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Parkinsonian Disorders; PPAR delta; Rats; Sulfones; Thiazoles; Thiophenes; Tyrosine 3-Monooxygenase | 2013 |
PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting.
Topics: Animals; Cell Nucleus; Dexamethasone; Forkhead Transcription Factors; Glucocorticoids; Muscle Fibers, Skeletal; Muscle Proteins; Muscles; Muscular Atrophy; Nerve Tissue Proteins; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Glucocorticoid; RNA, Small Interfering; Sepsis; SKP Cullin F-Box Protein Ligases; Thiazoles; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Up-Regulation | 2013 |
Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.
Topics: Cell Line, Tumor; Cell Nucleus; DNA; Dose-Response Relationship, Drug; HEK293 Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Ligands; Nuclear Receptor Coactivator 2; PPAR delta; Protein Binding; Receptors, Calcitriol; Rhodamines; Spectrophotometry; Thiazoles | 2013 |
Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Humans; Oxygen; PPAR delta; PPAR-beta; Rats; Retinal Diseases; Retinal Neovascularization; Retinal Vessels; Sulfones; Thiazoles; Thiophenes | 2013 |
Cardiac peroxisome proliferator-activated receptor δ (PPARδ) as a new target for increased contractility without altering heart rate.
Topics: Anesthesia; Animals; Animals, Newborn; Blood Pressure; Calcium; Diabetes Mellitus, Experimental; Dobutamine; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Intracellular Space; Male; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Phosphorylation; PPAR delta; Rats; Rats, Wistar; Streptozocin; Thiazoles; Troponin I; Ultrasonography | 2013 |
Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Endothelin-1; Endothelium, Vascular; Hypertension; NADPH Oxidases; PPAR-beta; Rats; Reactive Oxygen Species; RGS Proteins; Thiazoles; Vasodilation | 2013 |
Activation of receptors δ (PPARδ) by agonist (GW0742) may enhance lipid metabolism in heart both in vivo and in vitro.
Topics: Animals; Animals, Newborn; Citric Acid Cycle; Fatty Acids; Gene Expression Regulation; Lipid Metabolism; Male; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; PPAR delta; Rats; Rats, Wistar; Signal Transduction; Thiazoles | 2013 |
High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR- δ agonism.
Topics: Animals; Carbohydrates; Fibroblast Growth Factors; Gene Expression Regulation; Glucose; Glucose Tolerance Test; Immunohistochemistry; Inflammation; Insulin; Insulin Resistance; Interleukin-6; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Nutritive Sweeteners; PPAR delta; Signal Transduction; Thiazoles | 2013 |
A selective peroxisome proliferator-activated receptor-β/δ agonist attenuates neointimal hyperplasia after wire-mediated arterial injury.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Hyperplasia; Macrophages; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; PPAR delta; PPAR-beta; Regeneration; Thiazoles | 2013 |
Ligand-activated peroxisome proliferator-activated receptor β/δ modulates human endometrial cancer cell survival.
Topics: Apoptosis; beta Catenin; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endometrial Neoplasms; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Molecular Targeted Therapy; Peroxisome Proliferator-Activated Receptors; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Thiazoles | 2013 |
Activation of PPAR α and PPAR β/δ regulates Sertoli cell metabolism.
Topics: Acetyl-CoA Carboxylase; Acyl-CoA Dehydrogenase; Animals; Carnitine O-Palmitoyltransferase; CD36 Antigens; Fatty Acids; Gene Expression Regulation; Glucose; L-Lactate Dehydrogenase; Lactates; Male; Models, Biological; Phosphorylation; PPAR alpha; PPAR delta; PPAR-beta; Pyrimidines; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells; Thiazoles | 2014 |
Bioactivity screening and mass spectrometric confirmation for the detection of PPARδ agonists that increase type 1 muscle fibres.
Topics: Actins; Angiopoietin-Like Protein 4; Angiopoietins; Biological Assay; Cell Line, Tumor; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Limit of Detection; Mass Spectrometry; Muscle Fibers, Slow-Twitch; Phenoxyacetates; Polymerase Chain Reaction; PPAR delta; RNA, Messenger; Thiazoles | 2014 |
Transcriptional regulation of Δ6-desaturase by peroxisome proliferative-activated receptor δ agonist in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
Topics: Cell Line, Tumor; ErbB Receptors; Fatty Acid Desaturases; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; PPAR delta; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thiazoles; Tyrphostins | 2013 |
PPARδ activation inhibits homocysteine-induced p22(phox) expression in EA.hy926 cells through reactive oxygen species/p38MAPK pathway.
Topics: Antioxidants; Cell Line; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Homocysteine; Humans; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR gamma; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Thiazoles; Time Factors; Up-Regulation | 2014 |
Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels.
Topics: Acute Lung Injury; Animals; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Oxygen; PPAR delta; PPAR-beta; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfones; Thiazoles; Thiophenes; Up-Regulation | 2014 |
A PPAR-β/δ agonist is neuroprotective and decreases cognitive impairment in a rodent model of Parkinson's disease.
Topics: Animals; Blotting, Western; Brain; Cognition; Disease Models, Animal; DNA Fragmentation; In Situ Nick-End Labeling; Male; Maze Learning; Neurons; Neuroprotective Agents; Parkinsonian Disorders; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; Thiazoles | 2014 |
Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain.
Topics: Active Transport, Cell Nucleus; Animals; Arachidonic Acids; Blotting, Western; Brain; Cell Line, Tumor; Cell Nucleus; Cognition; Endocannabinoids; Fatty Acid-Binding Proteins; Gene Regulatory Networks; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polyunsaturated Alkamides; PPAR delta; PPAR-beta; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transcriptome | 2014 |
Ginseng is useful to enhance cardiac contractility in animals.
Topics: Anesthesia; Animals; Animals, Newborn; Calcium; In Vitro Techniques; Intracellular Space; Male; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Panax; Phosphorylation; Plant Extracts; PPAR delta; Rats, Wistar; Thiazoles; Troponin I | 2014 |
Activation of peroxisome proliferator-activated receptor β/δ attenuates acute ischemic stroke on middle cerebral ischemia occlusion in rats.
Topics: Animals; Brain; Brain Ischemia; Infarction, Middle Cerebral Artery; Interleukin-1beta; Male; Motor Activity; NF-kappa B; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; Stroke; Thiazoles; Tumor Necrosis Factor-alpha | 2014 |
Protective role of peroxisome proliferator-activated receptor β/δ in acute lung injury induced by prolonged hyperbaric hyperoxia in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Hyperoxia; Lung; Male; MAP Kinase Signaling System; Neuroprotective Agents; NF-kappa B; PPAR delta; PPAR-beta; Pressure; Random Allocation; Rats, Sprague-Dawley; Respiratory System Agents; Sulfones; Thiazoles; Thiophenes; Time Factors | 2014 |
Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice.
Topics: Acetyltransferases; Animals; Endoplasmic Reticulum Stress; Fatty Acid Elongases; Hep G2 Cells; Hepatocytes; Humans; Lipase; Liver; Male; Mice; Obesity; PPAR-beta; Thiazoles; Triglycerides | 2014 |
The PPARβ/δ agonist GW0742 modulates signaling pathways associated with cardiac myocyte growth via a non-genomic redox mechanism.
Topics: Animals; Gene Expression Regulation; Male; MAP Kinase Signaling System; Myocytes, Cardiac; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors; PTEN Phosphohydrolase; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes; Vanadates | 2014 |
Telmisartan inhibits the proinflammatory effects of homocysteine on human endothelial cells through activation of the peroxisome proliferator-activated receptor-δ pathway.
Topics: Benzimidazoles; Benzoates; Chemokine CCL2; Gene Expression Regulation; HL-60 Cells; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Inflammation Mediators; NF-kappa B; PPAR delta; Protein Transport; RNA, Messenger; Signal Transduction; Telmisartan; Thiazoles; Vascular Cell Adhesion Molecule-1 | 2014 |
Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.
Topics: Adult; Alcohol Drinking; Alcoholism; Alkanesulfonates; Animals; Bezafibrate; Brain; Female; Fenofibrate; Genome-Wide Association Study; Humans; Liver; Male; Mice; Phenylpropionates; Pioglitazone; Polymorphism, Single Nucleotide; PPAR alpha; PPAR gamma; Thiazoles; Thiazolidinediones | 2015 |
Effect of PPARδ agonist on stearoyl-CoA desaturase 1 in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
Topics: Cell Line, Tumor; Flavonoids; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; PPAR delta; Stearoyl-CoA Desaturase; Thiazoles | 2015 |
Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cell Adhesion Molecules; Cells, Cultured; Complement C1q; Complement C3; Disease Models, Animal; Embryo, Mammalian; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Phosphopyruvate Hydratase; PPAR delta; Thiazoles | 2015 |
PPAR-β/δ activation promotes phospholipid transfer protein expression.
Topics: Animals; Cell Line; Humans; Mice; Mice, Inbred C57BL; Phospholipid Transfer Proteins; PPAR delta; PPAR-beta; Thiazoles | 2015 |
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Axl Receptor Tyrosine Kinase; Benzoates; Benzylamines; Bexarotene; c-Mer Tyrosine Kinase; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Leukocyte Common Antigens; Macrophages; Male; Membrane Glycoproteins; Mice; Microglia; Myeloid Cells; Phagocytosis; Pioglitazone; Plaque, Amyloid; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones | 2015 |
Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.
Topics: Adiponectin; Adipose Tissue; Animals; Aorta; Blood Glucose; Caveolin 1; Diet, High-Fat; Endothelium, Vascular; Glucose Tolerance Test; Hypertension; Insulin Resistance; Interleukin-6; Male; Mice; Nitric Oxide Synthase Type III; Obesity; PPAR delta; PPAR-beta; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Vasodilation | 2015 |
The PPARβ/δ Agonist GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARβ/δ in Neuronal Maturation.
Topics: Animals; Cell Growth Processes; Cell Line; Neurogenesis; Neurons; PPAR delta; PPAR-beta; Rats, Sprague-Dawley; Signal Transduction; Thiazoles | 2016 |
Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.
Topics: Animals; Aorta; Blotting, Western; Calcimycin; Carnitine O-Palmitoyltransferase; Cells, Cultured; Diglycerides; Endothelium, Vascular; Enzyme Activation; Lipids; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Palmitic Acids; Phosphorylation; PPAR delta; PPAR-beta; Protein Kinase C-alpha; Reactive Oxygen Species; RNA Interference; Sulfones; Thiazoles; Thiophenes; Up-Regulation | 2015 |
Regulation of the orexigenic neuropeptide, enkephalin, by PPARδ and fatty acids in neurons of the hypothalamus and forebrain.
Topics: Animals; Cells, Cultured; Diet, High-Fat; Dose-Response Relationship, Drug; Embryo, Mammalian; Enkephalins; Fatty Acids; Gene Expression Regulation; Hypothalamus; Neurons; Oleic Acid; Palmitic Acid; PPAR delta; Prosencephalon; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Thiazoles; Transfection | 2015 |
Hippocampal PPARδ Overexpression or Activation Represses Stress-Induced Depressive Behaviors and Enhances Neurogenesis.
Topics: Animals; Cell Differentiation; Depression; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hindlimb Suspension; Hippocampus; Male; Mice; Mice, Inbred ICR; Neural Stem Cells; Neurogenesis; Phosphopyruvate Hydratase; PPAR delta; Sincalide; Stress, Psychological; Thiazoles; Time Factors; Transduction, Genetic | 2015 |
Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Discovery; Fructose; Glucose Transporter Type 4; Homeostasis; Hypoglycemic Agents; Insulin; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphoenolpyruvate Carboxykinase (GTP); PPAR alpha; Rats, Wistar; Streptozocin; Thiazoles; Time Factors | 2015 |
In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone receptor antagonist properties.
Topics: Animals; Binding, Competitive; Computer Simulation; Dose-Response Relationship, Drug; Epoprostenol; Humans; Ligands; Male; Mesenteric Arteries; Models, Molecular; Myography; Protein Domains; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Thyroid Hormone; Thiazoles; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Triiodothyronine; Vasodilation | 2016 |
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates promyogenic signaling pathways, thereby promoting myoblast differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Gene Expression Regulation, Developmental; MAP Kinase Signaling System; Mice; Muscle Development; Muscle Fibers, Skeletal; Myoblasts; PPAR gamma; PPAR-beta; Thiazoles | 2016 |
Effects of Peroxisome Proliferator-Activated Receptor-δ Agonist on Cardiac Healing after Myocardial Infarction.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Movement; Chemokine CXCL12; Echocardiography; Fibrosis; Heart; Heart Ventricles; Infusions, Parenteral; Male; Matrix Metalloproteinase 9; Mesenchymal Stem Cells; Myocardial Infarction; Myocardium; Myofibroblasts; Platelet-Derived Growth Factor; PPAR delta; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles; Transforming Growth Factor beta2; Ventricular Remodeling | 2016 |
PPARδ agonist GW0742 ameliorates Aβ1-42-induced hippocampal neurotoxicity in mice.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Caspase 3; Hippocampus; Interleukin-1beta; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; NF-kappa B; Peptide Fragments; PPAR delta; Thiazoles; Tumor Necrosis Factor-alpha | 2016 |
Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding.
Topics: Binding Sites; Cross-Linking Reagents; DNA; Humans; Ligands; PPAR delta; PPAR-beta; Protein Conformation; Protein Structure, Tertiary; Solutions; Tandem Mass Spectrometry; Thiazoles | 2016 |
Combined pharmacological activation of AMPK and PPARδ potentiates the effects of exercise in trained mice.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Calorimetry; Liver; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Physical Conditioning, Animal; Physical Endurance; PPAR delta; Ribonucleotides; Thiazoles | 2016 |
Pulmonary Administration of GW0742, a High-Affinity Peroxisome Proliferator-Activated Receptor Agonist, Repairs Collapsed Alveoli in an Elastase-Induced Mouse Model of Emphysema.
Topics: Animals; Disease Models, Animal; Forced Expiratory Volume; Lung; Mice; Pancreatic Elastase; PPAR delta; PPAR-beta; Pulmonary Emphysema; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Thiazoles; Vital Capacity | 2016 |
Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.
Topics: Animals; Aorta; Calcimycin; Cytochrome b Group; Endoplasmic Reticulum Stress; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; PPAR gamma; PPAR-beta; Primary Cell Culture; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Tissue Culture Techniques; Uncoupling Protein 2 | 2016 |
Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-β Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Mesenteric Arteries; Mice, Inbred C57BL; Norepinephrine; PPAR-beta; RGS Proteins; Sulfones; Thiazoles; Thiophenes; Vascular Resistance; Vasoconstriction | 2016 |
Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.
Topics: Animals; Coronary Vessels; Cyclic AMP; Diabetes Mellitus, Experimental; Humans; Hyperglycemia; KCNQ1 Potassium Channel; Male; PPAR delta; PPAR-beta; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Wistar; Reactive Oxygen Species; Thiazoles; Vasodilation | 2016 |
Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Hepatitis B; Hepatocytes; Kupffer Cells; Ligands; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Polymerase Chain Reaction; PPAR delta; PPAR-beta; Thiazoles | 2016 |
Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.
Topics: Acyltransferases; Anilides; Animals; Blotting, Northern; Caco-2 Cells; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Computational Biology; HT29 Cells; Humans; Kidney Tubules, Proximal; Liver; Mice; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; Real-Time Polymerase Chain Reaction; Rosiglitazone; Sulfones; Thiazoles; Thiazolidinediones; Thiophenes; Tyrosine | 2016 |
PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.
Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Corticosterone; CpG Islands; Endoplasmic Reticulum Stress; Methylation; MicroRNAs; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; Thiazoles | 2017 |
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Topics: Acute-Phase Reaction; Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Infarction; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Claudins; Infarction, Middle Cerebral Artery; Inflammation Mediators; Injections, Intraperitoneal; Liver; Male; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Neutrophil Infiltration; Occludin; Permeability; PPAR delta; PPAR-beta; RNA, Messenger; Thiazoles; Zonula Occludens-1 Protein | 2017 |
Peroxisome Proliferator Activated Receptor Beta (PPARβ) activity increases the immune response and shortens the early phases of skeletal muscle regeneration.
Topics: Animals; Cell Differentiation; Cell Proliferation; Immunophenotyping; Macrophages; Mice; Mice, Inbred C57BL; Muscle, Skeletal; PPAR-beta; Regeneration; T-Lymphocytes; Thiazoles; Transcription, Genetic | 2017 |
The Non-Genomic Effects of the PPARβγ Agonist GW0742 on Streptozotocin Treated Rat Aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Diabetes Mellitus, Experimental; Genome; Male; Myocardial Contraction; Phenylephrine; PPAR gamma; PPAR-beta; Protein Kinase Inhibitors; Rats, Wistar; rho-Associated Kinases; Streptozocin; Thiazoles; Vasodilation | 2018 |
Activation of Peroxisome Proliferator Activator Receptor β/δ Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Female; Hypertension; Lupus Erythematosus, Systemic; Mice; Mice, Inbred NZB; PPAR delta; Thiazoles | 2017 |
Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold.
Topics: Cell Survival; Drug Design; HEK293 Cells; High-Throughput Screening Assays; Humans; Ligands; Molecular Docking Simulation; PPAR delta; Receptors, Calcitriol; Small Molecule Libraries; Structure-Activity Relationship; Tetrazoles; Thiazoles; Transcription, Genetic | 2017 |
Dose-dependent effects of peroxisome proliferator-activated receptors β/δ agonist on systemic inflammation after haemorrhagic shock.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Male; Mice; PPAR delta; PPAR-beta; Shock, Hemorrhagic; Systemic Inflammatory Response Syndrome; Thiazoles | 2018 |
Role of endoplasmic reticulum stress in the protective effects of PPARβ/δ activation on endothelial dysfunction induced by plasma from patients with lupus.
Topics: Cells, Cultured; Endoplasmic Reticulum Stress; Endothelial Cells; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; PPAR delta; PPAR-beta; Thiazoles | 2017 |
Novel VDR antagonists based on the GW0742 scaffold.
Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Receptors, Calcitriol; Structure-Activity Relationship; Thiazoles; Transcriptional Activation | 2018 |
GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Body Weight; Cholesterol; Diet, High-Fat; Endoplasmic Reticulum Stress; Energy Intake; Energy Metabolism; Fatty Liver; Feeding Behavior; Glucose Tolerance Test; Hepatocytes; Inflammation; Insulin Resistance; Lipogenesis; Liver; Male; Mice, Inbred C57BL; Oxidation-Reduction; PPAR-beta; Protein Isoforms; Thiazoles | 2018 |
Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation.
Topics: Animals; Blood Coagulation; Cytokines; Female; Inflammation; Mice; PPAR delta; PPAR-beta; Sepsis; Sulfones; Thiazoles; Thiophenes | 2018 |
Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats.
Topics: Animals; Apoptosis; Benzamides; Carrier Proteins; Cell Cycle Proteins; Cerebral Infarction; Hypoxia-Ischemia, Brain; Male; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; MicroRNAs; Neurons; PPAR delta; PPAR-beta; Rats; Signal Transduction; Sulfones; Thiazoles | 2018 |
GW0742 activates peroxisome proliferator-activated receptor δ to reduce free radicals and alleviate cardiac hypertrophy induced by hyperglycemia in cultured H9c2 cells.
Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Cell Line; Free Radicals; Hyperglycemia; Rats; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes | 2018 |
PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes.
Topics: Adult; Animals; Astrocytes; Cell Differentiation; Cells, Cultured; Exons; Fatty Acids; Female; Humans; Induced Pluripotent Stem Cells; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Oxidation-Reduction; PPAR delta; PPAR-beta; Presenilin-1; Random Allocation; Thiazoles | 2019 |
Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice.
Topics: Animals; Diet, High-Fat; Energy Metabolism; Female; Glucose; Insulin Resistance; Lipid Metabolism; Lymphocyte Count; Mice; Mice, Obese; Muscle, Skeletal; Obesity; Physical Conditioning, Animal; PPAR delta; PPAR-beta; T-Lymphocytes, Regulatory; Thiazoles; Weight Loss | 2019 |
Vascular PPARβ/δ Promotes Tumor Angiogenesis and Progression.
Topics: Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Disease Progression; Endothelial Cells; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Mice; Neovascularization, Pathologic; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-kit; Receptor, Platelet-Derived Growth Factor beta; Thiazoles | 2019 |
Activation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model.
Topics: Animals; Apoptosis; Brain Injuries; Cerebral Hemorrhage; Collagenases; Gliosis; Inflammation; Male; Mice, Inbred C57BL; Neuroprotective Agents; PPAR delta; PPAR-beta; Thiazoles; Up-Regulation | 2020 |
VCAM-1-targeted and PPARδ-agonist-loaded nanomicelles enhanced suppressing effects on apoptosis and migration of oxidized low-density lipoprotein-induced vascular smooth muscle cells.
Topics: Apoptosis; Cell Movement; Cells, Cultured; Drug Carriers; Drug Compounding; Drug Liberation; Humans; Lipoproteins, LDL; Micelles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanoparticles; PPAR gamma; Signal Transduction; Thiazoles; Vascular Cell Adhesion Molecule-1 | 2020 |
Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A.
Topics: Cell Movement; Cell Proliferation; Fatty Acids; Glycolysis; Human Umbilical Vein Endothelial Cells; Humans; Mitochondria; Oxidation-Reduction; PPAR delta; PPAR-beta; Sirtuin 1; Thiazoles; Vascular Endothelial Growth Factor A | 2020 |
Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?
Topics: Adult; Cell Differentiation; Cells, Cultured; Decidua; Endometrium; Female; Humans; Infertility, Female; Ligands; Molecular Targeted Therapy; PPAR delta; PPAR-beta; Stromal Cells; Sulfones; Thiazoles; Thiophenes; Up-Regulation | 2020 |
GW0742 activates miR-17-5p and inhibits TXNIP/NLRP3-mediated inflammation after hypoxic-ischaemic injury in rats and in PC12 cells.
Topics: Animals; Blood Glucose; Cell Cycle Proteins; Cell Survival; Female; Glucose; Hypoxia; Inflammasomes; Inflammation; Ischemia; Male; MicroRNAs; Microscopy, Fluorescence; NLR Family, Pyrin Domain-Containing 3 Protein; Oxygen; PC12 Cells; Rats; Rats, Sprague-Dawley; Thiazoles | 2020 |
PPAR-δ activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells.
Topics: Apoptosis; Autophagy; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cisplatin; Epithelial Cells; Kidney Diseases; Kidney Tubules, Proximal; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53 | 2021 |
Synthesis and Evaluation of PPARδ Agonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Drug Design; Female; Femur; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteogenesis; Osteoporosis; PPAR delta; Structure-Activity Relationship; Thiazoles; X-Ray Microtomography | 2021 |
Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Angiopoietin-Like Protein 4; Animals; Antioxidants; Cadherins; Cardiotonic Agents; Catalase; Energy Metabolism; Male; Mitochondria, Heart; Models, Biological; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; PPAR delta; PPAR-beta; Rats, Wistar; Superoxide Dismutase; Thiazoles; Uncoupling Protein 3; Up-Regulation | 2021 |
Gene Doping with Peroxisome-Proliferator-Activated Receptor Beta/Delta Agonists Alters Immunity but Exercise Training Mitigates the Detection of Effects in Blood Samples.
Topics: Animals; Cells, Cultured; Exercise; Fatty Acids; Humans; Inflammation; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Performance-Enhancing Substances; PPAR delta; PPAR-beta; Substance Abuse Detection; T-Lymphocytes, Regulatory; Thiazoles | 2021 |
Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model.
Topics: Animals; Astrocytes; Endoplasmic Reticulum Stress; Endoribonucleases; Mice; Mitophagy; Phenols; PPAR delta; PPAR-beta; Protein Serine-Threonine Kinases; Sulfhydryl Compounds; Thiazoles; Uncoupling Protein 2 | 2022 |