thiazoles has been researched along with gw 501516 in 223 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 77 (34.53) | 29.6817 |
| 2010's | 130 (58.30) | 24.3611 |
| 2020's | 16 (7.17) | 2.80 |
| Authors | Studies |
|---|---|
| Bodkin, NL; Hansen, BC; Kliewer, SA; Lambert, MH; Lewis, MC; Oliver, WR; Plunket, KD; Russell, CS; Shenk, JL; Snaith, MR; Sternbach, DD; Sznaidman, ML; Willson, TM; Winegar, DA; Xu, HE | 1 |
| Chao, E; Fivush, A; Goreham, D; Haffner, CD; Lambert, MH; LeGrumelec, C; Maloney, PR; Montana, VG; Oliver, WR; Sierra, ML; Sternbach, DD; Sznaidman, ML; Willson, TM; Xu, HE | 1 |
| Evans, RM; Ham, J; Kang, H; Lee, CH; Tiep, S; Wang, YX; Yu, RT | 1 |
| Ehrenborg, E; Glinghammar, B; Hamsten, A; Skogsberg, J | 1 |
| Allen, TL; Dressel, U; Lau, P; Muscat, GE; Pippal, JB; Rohde, PR | 1 |
| Kozikowski, AP; Wei, ZL | 1 |
| Asaba, H; Auwerx, J; Doi, T; Hamakubo, T; Hamura, H; Iguchi, H; Ikeda, Y; Ioka, RX; Ito, S; Iwasaki, S; Kodama, T; Magoori, K; Naito, M; Sakai, J; Sumi, K; Tachibana, K; Tanaka, T; Uchiyama, Y; Watanabe, M; Watanabe, Y; Yamamoto, J; Yanagisawa, M | 1 |
| Dey, SK; DuBois, RN; Gupta, RA; Katkuri, S; Wang, D; Wang, H | 1 |
| Auwerx, J; Brown, BE; Cairns, WJ; Chambon, P; Chang, S; Chuang, G; Dorsam, S; Elias, PM; Feingold, KR; Fowler, AJ; Haqq, CM; Holder, JC; Lau, P; Mao-Qiang, M; Moser, AH; Schmuth, M; Schoonjans, K; Uchida, Y; Willson, TM | 1 |
| Ehrenborg, E; Gustafsson, MC; Harris, AL; Jarvis, M; Knight, D; Marshall, BR; Palmer, CN; Stephen, RL; Tatoud, R; Wolf, CR | 1 |
| Sakai, J | 1 |
| Fredenrich, A; Gaudel, C; Grimaldi, PA; Holst, D; Jehl-Pietri, C; Lopez-Soriano, J; Luquet, S | 1 |
| Baller, JF; Chimini, G; Groen, AK; Groot, PH; Havinga, R; Kruit, JK; Kuipers, F; Lestavel, S; Staels, B; van der Veen, JN | 1 |
| Chai, A; Coward, P; Houze, J; Kelley, KL; Rudel, LL; Sawyer, JK; Schwarz, M; Wallace, JM | 1 |
| Al-Khalili, L; Ehrenborg, E; Kannisto, K; Krämer, DK; Krook, A; Perrini, S; Skogsberg, J; Wallberg-Henriksson, H; Wretenberg, P; Zierath, JR | 1 |
| Bai, R; Dettin, LE; Glazer, RI; Kopelovich, L; Kopleovich, L; Kozikowski, AP; Russell, RG; Wei, ZL; Yin, Y | 1 |
| Fu, J; Gaetani, S; Lin, E; Oveisi, F; Piomelli, D | 1 |
| Knight, B; Olynyk, JK; Yeap, BB; Yeoh, GC | 1 |
| Balaguer, P; Carlavan, I; Lemaire, G; Nicolas, JC; Perrin, A; Pillon, A; Seimandi, M; Vignon, F; Voegel, JJ | 1 |
| Han, S; Ritzenthaler, JD; Roman, J; Wingerd, B | 1 |
| Johnson, TE; Shi, S; Umbenhauer, DR; Zhang, X | 1 |
| de Lera, AR; Gaudon, C; Germain, P; Gronemeyer, H; Iglesias, B; Pereira, R | 1 |
| Han, DH; Holloszy, JO; Terada, S; Wicke, S | 1 |
| Connat, JL; Dutartre, P; Grimaldi, PA; Pesant, M; Rochette, L; Sueur, S; Tallandier, M | 1 |
| Inada, Y; Kuroda, J; Maruyama, K; Nagasawa, T; Nakano, S; Shibata, N; Takahashi, T; Tamura, T; Yamazaki, Y | 1 |
| Pelton, P | 1 |
| Cnop, M; Darville, MI; Eizirik, DL; Evans, RM; Hekerman, P; Kharroubi, I; Lee, CH | 1 |
| Anderwald, C; Brunmair, B; Dörig, J; Fürnsinn, C; Gras, F; Marian, V; Nohl, H; Stadlbauer, K; Staniek, K; Szöcs, Z; Waldhäusl, W | 1 |
| Han, C; Wu, T; Xu, L | 1 |
| Tanaka, T | 1 |
| Alfranca, A; Bishop-Bailey, D; Hatae, T; Hodivala-Dilke, KM; Piqueras, L; Redondo, JM; Reynolds, AR; Tanabe, T; Warner, TD | 1 |
| Ancellin, N; Billin, AN; Hassall, DG; Johnson, TG; Lobe, DC; Massien, C; Patterson, SD; Pearce, G; Perlstein, I; Sprecher, DL; Willson, TM | 1 |
| Desvergne, B; Dey, SK; DuBois, RN; Guo, Y; Katkuri, S; Ning, W; Wahli, W; Wang, D; Wang, H | 1 |
| Iwashita, A; Kita, Y; Matsuoka, N; Mihara, K; Moriguchi, A; Muramatsu, Y; Muramoto, M; Yamazaki, S; Yamazaki, T | 1 |
| Alcorn, JL; Baldini, A; Brunelli, L; Cieslik, KA; Vatta, M | 1 |
| Chen, S; Gao, J; Jiang, J; Li, R; Liu, P; Pi, R; Tang, F; Wang, P; Zhang, H; Zhou, S | 1 |
| Chrousos, GP; Kino, T; Rice, KC | 1 |
| Al-Khalili, L; Garcia-Roves, PM; Guigas, B; Krämer, DK; Krook, A; Leng, Y | 1 |
| Aoyama, A; Hashimoto, Y; Hirono, S; Ishizawa, M; Kasuga, J; Makishima, M; Miyachi, H; Nakagome, I; Ogura, M; Sako, K | 1 |
| De Windt, LJ; Smeets, PJ; Teunissen, BE; Van Bilsen, M; Van der Vusse, GJ; Willemsen, PH | 1 |
| Ebdrup, S; Havranek, M; Jeppesen, CB; Johansson, E; Korínek, M; Mogensen, JP; Pettersson, I; Pihera, P; Sauerberg, P | 1 |
| Amin, S; Billin, AN; Borland, MG; Girroir, EE; Gonzalez, FJ; Hollingshead, HE; Killins, RL; Peters, JM; Sharma, AK; Willson, TM | 1 |
| Meissner, W; Müller, R; Müller-Brüsselbach, S; Rieck, M; Wedeken, L | 1 |
| Dimopoulos, N; Green, C; Hundal, HS; Watson, M | 1 |
| Chang, KC; Ham, SA; Hwang, JY; Kim, HJ; Kim, JH; Kim, SU; Seo, HG; Yabe-Nishimura, C | 1 |
| Basu, S; Cheeseman, J; Danoff, T; Fang, Z; Fielding, BA; Frayn, KN; Hassall, D; Hegde, P; Hirschberg, S; Humphreys, SM; Johnson, T; Karpe, F; Liu, A; Moore, NR; Murgatroyd, P; O'Rahilly, S; Olson, E; Richards, D; Risérus, U; Sarov-Blat, L; Sprecher, D; Strum, JC; Sutton, P; Willson, T | 1 |
| Sprecher, DL | 1 |
| Chien, S; Fan, Y; Guan, Y; Qin, X; Staels, B; Tang, Z; Wang, N; Wang, X; Wang, Y; Zhang, H; Zhu, Y | 1 |
| Amin, S; Billin, AN; Girroir, EE; Gonzalez, FJ; Hollingshead, HE; Peters, JM; Robertson, GP; Sharma, AK; Willson, TM | 1 |
| Han, S; Ritzenthaler, JD; Roman, J; Zheng, Y | 1 |
| Coll, T; Laguna, JC; Merlos, M; Michalik, L; Moullan, N; Palomer, X; Rodríguez-Calvo, R; Sánchez, RM; Serrano, L; Vázquez-Carrera, M; Wahli, W | 1 |
| Ehrenborg, E; Glinghammar, B; Lundell, K; Skogsberg, J; Thulin, P | 1 |
| d'Uscio, LV; He, T; Katusic, ZS; Lam, CF; Lee, HC; Lu, T | 1 |
| Biscetti, F; Pola, R | 1 |
| Banayo, E; Downes, M; Embler, E; Evans, RM; Juguilon, H; Kang, H; Mihaylova, MM; Narkar, VA; Nelson, MC; Shaw, RJ; Wang, YX; Yu, RT; Zou, Y | 1 |
| Chen, W; Li, S; Liu, HY; Long, L; Wang, LL | 1 |
| Amin, S; Borland, MG; Foreman, JE; Girroir, EE; Gonzalez, FJ; Peters, JM; Ross, AC; Sharma, AK; Zolfaghari, R | 1 |
| Geng, Y; Kroll, TG; Sicinski, P; Tretiakova, M; Yu, X; Zeng, L | 1 |
| Cho, CH; Cho, HJ; Han, JK; Hur, J; Jun, SI; Kang, HJ; Kim, HS; Kim, JY; Koh, GY; Lee, HS; Lee, HY; Oh, BH; Park, KW; Park, YB; Peters, JM; Yang, HM | 1 |
| Han, S; Ritzenthaler, JD; Roman, J; Sun, X; Zheng, Y | 1 |
| Baar, K; Hardie, DG | 1 |
| Billin, AN | 1 |
| Fuchs, RK; Warden, SJ | 1 |
| Goodyear, LJ | 1 |
| Facchini, G; Ferrari, F; Gemelli, C; Grande, A; Lymboussaki, A; Mavilio, F; Testa, A | 1 |
| Deangelis, A; Demarest, K; Kuo, GH; Li, X; Murray, WV; Pelton, P; Russell, R; Sieber-McMaster, E; Wang, A; Xu, J; Zhang, R; Zhou, L; Zhu, P | 1 |
| Akita, N; Fukutomi, T; Gonzalez, FJ; Hossain, MA; Kimura, G; Ogata, M; Staels, B; Suzuki, S; Tsujita, M; Yokoyama, S | 1 |
| Beuck, S; Kohler, M; Kortner, B; Rodchenkov, G; Schänzer, W; Thevis, M; Thomas, A | 1 |
| Han, S; Ritzenthaler, JD; Roman, J | 1 |
| Giordano, C; Gounon, P; Grimaldi, P; Hatem, SN; Jehl-Piétri, C; Lopez, P; Murdaca, J; Schwartz, C; Wagner, KD; Wagner, N | 1 |
| Gosker, HR; Langen, RC; Remels, AH; Russell, AP; Schols, AM; Schrauwen, P; Spaapen, F; Voncken, JW | 1 |
| Braissant, O; Defaux, A; Honegger, P; Monnet-Tschudi, F; Zurich, MG | 1 |
| Aumiller, J | 1 |
| Ametller, E; Argilés, JM; Busquets, S; Figueras, M; Fontes de Oliveira, CC; Fuster, G; Grimaldi, PA; López-Soriano, FJ; Oliván, M | 1 |
| Akiba, Y; Ishii, H; Kamada, T; Sato, K; Toyomizu, M; Yonemura, T | 1 |
| Amin, S; Foreman, JE; Gonzalez, FJ; Peters, JM; Sharma, AK | 1 |
| Ali, FY; Desvergne, B; Hall, MG; Mitchell, JA; Warner, TD | 1 |
| Bélanger, G; Boudreault, L; Chakkalakal, JV; Hébert, RL; Jasmin, BJ; Miura, P; Renaud, JM | 1 |
| Ali, F; Ali, NS; Bauer, A; Boyle, JJ; Hamdulay, SS; Haskard, DO; Mason, JC; Randi, AM | 1 |
| Beuck, S; Bornatsch, W; Geyer, H; Möller, I; Rodchenkov, G; Schänzer, W; Thevis, M; Thomas, A | 1 |
| Jiang, L; Ke, L; Li, X; Lü, Q; Tong, N; Wan, J | 1 |
| Alpert, E; Cohen, G; Eckel, J; Gruzman, A; Guichardant, M; Riahi, Y; Sasson, S; Sin-Malia, Y; Staels, B | 1 |
| Artis, DR; Bollag, G; Erbe, DV; Gareski, T; Gartrell, K; Harding, K; Ibrahim, PN; Jalenak, M; Kubasiak, D; Lin, JJ; Mansour, TS; Panza, D; Perreault, M; Saiah, E; Tobin, JF; Vlasuk, GP; Wang, S; Will, S; Womack, P | 1 |
| Hashimoto, K; Iwasaki, Y; Kambayashi, M; Nakayama, S; Nishiyama, M; Okazaki, M; Taguchi, T; Terada, Y; Tsugita, M | 1 |
| Alvarez-Guardia, D; Barroso, E; Coll, T; Gómez-Foix, AM; Laguna, JC; Palomer, X; Vázquez-Carrera, M | 1 |
| Baron, DM; Hudec, X; Kaindl, U; Koneczny, I; König, JS; Marian, B; Röhrl, C | 1 |
| Chang, KC; Han, CW; Hwang, JS; Kim, HJ; Kim, JH; Kim, MY; Lee, JH; Seo, HG | 1 |
| Aasen, AJ; Ciocoiu, CC; Hansen, TV; Nguyen, HH; Nikolić, N; Thoresen, GH | 1 |
| Adams, SM; Bright, JJ; Chearwae, W; Iams, W; Kanakasabai, S; Walline, CC | 1 |
| Chen, YE; Deng, Z; Hamblin, M; Huang, H; Jiang, X; Wang, Y; Xiang, Y; Yin, KJ; Zhang, J | 1 |
| Beuck, S; Geyer, H; Kohler, M; Loo, JA; Möller, I; Rodchenkov, G; Schäfer, M; Schänzer, W; Thevis, M; Thomas, A; Yin, S | 1 |
| Bonen, A; Chabowski, A; Cresser, J; Dyck, DJ; Gulli, R; Ritchie, I; Stefanyk, LE | 1 |
| Amin, S; He, P; Peters, JM; Sharma, AK; Sk, UH | 1 |
| Adhikary, T; Finkernagel, F; Kaddatz, K; Meissner, W; Müller, R; Müller-Brüsselbach, S | 1 |
| Adhikary, T; Finkernagel, F; Kaddatz, K; Meissner, W; Müller, R; Müller-Brüsselbach, S; Stockert, J | 1 |
| Alvarez-Guardia, D; Coll, T; Davidson, MM; El Kochairi, I; Merlos, M; Michalik, L; Palomer, X; Rodríguez-Calvo, R; Serrano, L; Vázquez-Carrera, M; Wahli, W | 1 |
| Ciocoiu, CC; Hansen, TV; Ravna, AW; Sylte, I | 1 |
| Brindle, PK; Dent, SY; Ge, K; Jin, Q; Kasper, LH; Lee, JE; Wang, C; Wang, L; Yu, LR; Zhang, Z | 1 |
| Barroso, E; Eyre, E; Palomer, X; Vázquez-Carrera, M | 1 |
| Bahekar, R; Giri, S; Jain, M; Makadia, P; Patel, D; Patel, P; Pingali, H; Pola, S; Priyadarshini, P; Shah, M; Shah, SR; Suthar, D; Thube, B; Trivedi, C; Zaware, P | 1 |
| Kobilo, T; van Praag, H; Yuan, C | 1 |
| Cooney, GJ; Kraegen, EW; Li, HY; Sauerberg, P; Tid-Ang, J; Turner, N; Wulff, EM; Ye, JM; Zeng, XY | 1 |
| Chang, KC; Ham, SA; Han, CW; Hwang, JS; Jin, H; Jung, SY; Kang, ES; Kim, HJ; Kim, MY; Lee, JH; Paek, KS; Seo, HG; Woo, IS | 1 |
| Astudillo, AM; Balsinde, J; Barroso, E; Palomer, X; Rodríguez-Calvo, R; Serrano-Marco, L; Vázquez-Carrera, M | 1 |
| Berlinski, B; Doll, M; Gille, J; Hrgovic, I; Kaufmann, R; Kippenberger, S; Laubach, V; Meissner, M; Reichenbach, G | 1 |
| Hwang, SJ; Jun, JH; Kang, HJ; Lim, HJ; Song, H; Yoon, JA; Yoon, TK | 1 |
| Chung, WY; Lee, J | 1 |
| Geyer, H; Schänzer, W; Thevis, M; Thomas, A | 1 |
| Fritsche, A; Häring, HU; Heni, M; Machicao, F; Ordelheide, AM; Staiger, H; Stefan, N; Thamer, C | 1 |
| El Kochairi, I; Michalik, L; Palomer, X; Rodríguez-Calvo, R; Serrano-Marco, L; Vázquez-Carrera, M; Wahli, W | 1 |
| DuBois, RN; Guo, L; Ning, W; Wang, D; Xie, D | 1 |
| Barrett, PH; Chan, DC; Ooi, EM; Sprecher, DL; Watts, GF | 1 |
| Cho, HJ; Choi, YE; Han, JK; Jang, JJ; Jeon, KH; Kang, HJ; Kim, HL; Kim, HS; Kwon, YW; Lee, HS; Oh, BH; Park, YB | 1 |
| Glazer, RI; Kopelovich, L; Upadhyay, G; Yin, Y; Yuan, H | 1 |
| Araki, S; Chin-Kanasaki, M; Han, P; Haneda, M; Isshiki, K; Kashiwagi, A; Koya, D; Kume, S; Li, D; Maegawa, H; Nishio, Y; Sugaya, T; Sugimoto, T; Tanaka, Y; Uzu, T; Yang, X | 1 |
| Goh, YY; Huang, RL; Pal, M; Tan, MJ; Tan, NS; Tang, MB; Wang, XL | 1 |
| Ciocoiu, CC; Hansen, TV; Ravna, AW; Rustan, AC; Sylte, I | 1 |
| Staels, B; Tailleux, A; Wouters, K | 1 |
| Inoue, J; Kinoshita, S; Nakamura, T; Nakamura, Y; Tarui, T | 1 |
| Barroso, E; El Kochairi, I; Michalik, L; Palomer, X; Serrano-Marco, L; Vázquez-Carrera, M; Wahli, W | 1 |
| Kim, H; Kwak, HJ; Lee, KS; Lim, HJ; Park, HY; Park, JH | 1 |
| Ham, SA; Hwang, JS; Kang, ES; Kim, JH; Lee, H; Lee, HT; Min, G; Oh, JW; Park, C; Seo, HG; Yoo, T | 1 |
| Ham, SA; Han, CW; Hwang, JS; Kang, ES; Kim, HJ; Kim, JH; Kim, MY; Lee, H; Lim, DS; Paek, KS; Park, C; Seo, HG; Yoo, T | 1 |
| Brenner, DA; Downes, M; Evans, RM; Haimerl, M; Iwaisako, K; Kodama, Y; Paik, YH; Schnabl, B; Sirlin, C; Taura, K; Yu, E; Yu, RT | 1 |
| Chai, Q; d'Uscio, LV; He, T; Katusic, ZS; Lee, HC; Lu, T; Yu, L | 1 |
| Jones, NP; Olson, EJ; Pearce, GL; Sprecher, DL | 1 |
| Ehrenborg, E; Kroupa, O; Makoveichuk, E; Olivecrona, G; Olivecrona, T; Sukonina, V; Thulin, P | 1 |
| d'Uscio, LV; Das, P; He, T; Katusic, ZS; Santhanam, AV; Younkin, SG | 1 |
| Ala, U; Arai, F; Avigan, DE; Carracedo, A; Evans, RM; Ito, K; Lee, CH; Pandolfi, PP; Schafer, ZT; Suda, T; Weiss, D | 1 |
| Cheang, WS; Chen, ZY; Cooke, JP; Huang, Y; Lee, SS; Liu, J; Liu, L; Liu, Y; Lu, Y; Tian, XY; Wang, N; Wong, WT; Yao, X | 1 |
| Dikunets, M; Rodchenkov, G; Sobolevsky, T; Sukhanova, I; Virus, E | 1 |
| d'Uscio, LV; He, T; Katusic, ZS; Santhanam, AV | 1 |
| Dai, SS; He, FT; Li, GB; Li, J; Li, P; Yang, K; Zhang, Y; Zhou, YG | 1 |
| Alitalo, K; Anisimov, A; Eckel, RH; Ehnholm, C; Jauhiainen, M; Koistinen, HA; Olkkonen, VM; Robciuc, MR; Skrobuk, P | 1 |
| Bernd, A; Doll, M; Hrgovic, I; Kaufmann, R; Kippenberger, S; Meissner, M; Reichenbach, G; Starzinski-Powitz, A; Valesky, EM | 1 |
| Beuck, S; Möller, I; Schänzer, W; Thevis, M | 1 |
| Chowdhury, VS; Hattori, MA; Kaneto, M; Kawai, M; Nakano, N; Nishimura, K; Torii, M; Yamauchi, N | 1 |
| Bojic, LA; Huff, MW | 1 |
| Cheung, L; Corcoran, M; Ehrenborg, E; Fisher, RM; Grandér, D; Thulin, P; Wei, T; Werngren, O | 1 |
| Hao, P; Li, R; Li, X; Li, Y; Liu, G; Sun, Y; Tang, X; Xu, J | 1 |
| Ham, SA; Hwang, JS; Kang, ES; Kim, JH; Lee, H; Lim, DS; Paek, KS; Park, C; Seo, HG; Yoo, T | 1 |
| Fant, ME; Glazer, RI; Kallakury, B; Kopelovich, L; Lu, J; Umans, R; Upadhyay, G; Xiao, J; Yin, Y; Yuan, H | 1 |
| Abe, Y; Balasubramanyam, A; Kino, T; Kopp, JB; Lagranha, C; Lee, H; Lopaschuk, GD; Okamoto, K; Shrivastav, S; Zhang, L | 1 |
| Bulun, SE; Chakravarti, D; Coon, JS; Dyson, MT; Kim, JJ; Ma, JJ; Malpani, S; Monsivais, D; Ono, M; Pavone, ME; Xin, H; Zhao, H | 1 |
| Bakke, SS; Boekschoten, MV; Feng, YZ; Kase, ET; Kersten, S; Nikolić, N; Rustan, AC; Thoresen, GH | 1 |
| Bojic, LA; Burke, AC; Chhoker, SS; Edwards, JY; Huff, MW; Pickering, JG; Sawyez, CG; Sutherland, BG; Telford, DE; Tirona, RG; Yin, H | 1 |
| Lione, L; Mackenzie, LS | 1 |
| Abbott, MJ; Ahmadian, M; Lopes, AB; Sul, HS; Tang, T; Wang, Y | 1 |
| Gong, M; Lu, Y; Mao, T; Tong, N; Tong, Y; Wang, C; Yang, Q; Yang, Y; Zhou, M | 1 |
| Blokland, M; Bovee, TF; Essers, ML; Hamers, AR; Heskamp, HH; Kersten, S; Nielen, MW; van Ginkel, LA | 1 |
| Rajagopal, R; Semenkovich, CF | 1 |
| Li, D; Li, L; Su, X; Wang, Y; Yang, X; Yu, R; Zhou, G | 1 |
| Chew, GT; Sahebkar, A; Watts, GF | 1 |
| Baatjes, AJ; Campbell, H; Dua, B; Gauvreau, GM; Hill, M; Howie, K; Oliveria, JP; Sehmi, R; Smith, SG; Watson, BM; Watson, RM | 1 |
| Ericsson, M; Eriksen, EF; Mosti, MP; Pullisaar, H; Reseland, JE; Shabestari, M; Stunes, AK; Syversen, U | 1 |
| Barroso, E; Botteri, G; Capdevila-Busquets, E; Davidson, MM; Michalik, L; Palomer, X; Salvadó, L; Vázquez-Carrera, M; Wahli, W | 1 |
| Wang, C; Zeng, Z; Zhou, G | 1 |
| Ding, H; Liu, L; Qu, J; Shen, R; Yuan, H; Zhang, Y | 1 |
| Fujiwara, S; Katagiri, F; Kato, A; Kumai, J; Matsuo, N; Nomizu, M; Okamoto, O; Wu, W; Yamada, Y | 1 |
| Do, JT; Ham, SA; Han, CW; Hwang, JS; Kang, ES; Kim, JH; Lee, H; Oh, JW; Paek, KS; Park, C; Seo, HG; Yoo, T | 1 |
| Cholbinski, P; Kaliszewski, P; Konczak, D; Kowalczyk, K; Pokrywka, A; Zembron-Lacny, A | 1 |
| Beier, F; Borradaile, N; LeBlanc, EA; Mort, JS; Ratneswaran, A; Walser, E; Welch, I | 1 |
| Chiba, S; Chong, HC; Choong, C; Foo, S; Lee, WL; Loo, SC; Luo, B; Ng, KW; Sng, MK; Tan, NS; Tang, MB; Tong, BM; Wang, X; Wong, MT; Zhu, P | 1 |
| Bérubé-Simard, FA; Bousette, N; Haffar, T | 1 |
| Akashi, H; Castillero, E; George, I; Homma, S; Ji, R; Kennel, PJ; Schulze, PC; Zizola, C | 1 |
| Barroso, E; Chacón, MR; Ferrer, L; Maymó-Masip, E; Palomer, X; Rodríguez-Rodríguez, R; Salmerón, E; Salvadó, L; Vázquez-Carrera, M; Vendrell, J; Wabistch, M; Wahli, W | 1 |
| Do, JT; Eun, SY; Ham, SA; Hwang, JS; Lee, WJ; Lim, DS; Paek, KS; Seo, HG; Yoo, T | 1 |
| Aguila, MB; Magliano, DC; Mandarim-de-Lacerda, CA; Penna-de-Carvalho, A; Vazquez-Carrera, M | 1 |
| Fang, L; Fang, X; Liu, A; Wang, N; Wang, X; Zhao, B | 1 |
| Chen, W; Dong, F; Gao, R; Li, H; Li, S; Wang, L; Xie, X; Zheng, Z | 1 |
| Beniwal, M; Grewal, AS; Lather, V; Pandita, D; Sekhon, BS | 1 |
| Abdalla, DS; Brüne, B; Cavalcante, MF; Finkernagel, F; Kemmerer, M; Müller, R; Namgaladze, D | 1 |
| Dong, L; Li, H; Li, J; Li, X; Liang, C; Lu, X; Ma, H; Shi, H; Xie, D | 1 |
| Gao, Q; Ou, Z; Tong, Q; Wu, L; Zhang, Y; Zhu, D | 1 |
| Andel, M; Malisova, L; Trnka, J; Tumova, J | 1 |
| Do, JT; Ham, SA; Han, CW; Hwang, JS; Kim, JH; Lee, WJ; Oh, JW; Paek, KS; Seo, HG; Yoo, T | 1 |
| Laher, I; Li, S | 2 |
| Do, JT; Ham, SA; Hwang, JS; Kim, JH; Lee, WJ; Oh, JW; Paek, KS; Park, CK; Seo, HG; Yoo, T | 1 |
| Byun, KS; Je, J; Kang, K; Kang, SH; Kim, HR; Kim, JH; Ko, EJ; Lee, BJ; Lee, HJ; Seo, YS; Suh, SJ; Yeon, JE; Yim, HJ; Yoo, YJ; Yoon, EL | 1 |
| Ihling, CH; Schwarz, R; Sinz, A; Tänzler, D | 1 |
| Atkins, AR; Downes, M; Evans, RM; Wall, CE; Yu, RT | 1 |
| Chen, J; Mou, D; Qu, C; Yang, H; Zhang, C | 1 |
| Bittard, H; Fauconnet, S; Lascombe, I; Péchery, A | 1 |
| Banach, M; Castellino, G; Ivanova, E; Montalto, G; Nikolic, D; Orekhov, AN; Rizzo, M; Toth, PP | 1 |
| Duarte, J; Jiménez, R; Pérez-Vizcaíno, F; Romero, M; Toral, M | 1 |
| Lippi, G; Perez-Quilis, C; Sanchis-Gomar, F | 1 |
| Choi, JW; Cui, XS; Guo, J; Kim, NH; Liang, S; Lu, WF | 1 |
| Jiang, H; Shi, Y; Yang, X | 1 |
| Ham, SA; Han, DW; Han, SG; Hur, J; Hwang, JS; Hwang, SI; Lee, CH; Lee, WJ; Paek, KS; Park, JA; Seo, HG; Shin, HC; Yoo, T | 1 |
| Babu, DRK; Chellur, S; Fredenburg, RA; Goddeeris, MM; Jaleel, M; Kluge, AF; Lagu, B; Patane, MA; Senaiar, RS; Takahashi, T; Tiwari, NK; Tozzo, E | 1 |
| Ham, SA; Han, SG; Hong, K; Hwang, JS; Lee, CH; Lee, WJ; Lim, DS; Paek, KS; Seo, HG; Yoo, H; Yoo, T | 1 |
| Ahn, MY; Ham, SA; Han, SG; Hwang, JS; Lee, CH; Lee, WJ; Lim, DS; Paek, KS; Seo, HG; Yoo, T | 1 |
| Chin, J; Cho, SJ; Hwang, H; Joo, J; Kadayat, TM; Kang, H; Kim, DS; Kim, KH; Lee, J; Londhe, AM; Pae, AN | 1 |
| Choi, MJ; Ham, SA; Han, SG; Hwang, JS; Kim, E; Lee, CH; Lee, WJ; Paek, KS; Seo, HG; Yoo, T; Youn, JH | 1 |
| Hou, Y; Jin, J; Liu, Q; Shi, J; Zhou, D | 1 |
| Chen, Y; Deng, L; Hu, L; Li, Z; Liu, B; Xu, Y; Zhang, L; Zhou, Z | 1 |
| Choi, MJ; Hwang, JS; Kang, ES; Lee, GH; Lee, WJ; Lim, DS; Paek, KS; Seo, HG | 1 |
| Jang, HJ; Jung, Y; Kim, SN; Kim, WJ; Kim, YK; Lee, W | 1 |
| Afford, SC; Attard, J; Bhogal, RH; Boteon, APCS; Boteon, YL; Hubscher, S; Mergental, H; Mirza, DF; Reynolds, G; Wallace, L | 1 |
| Gu, L; Ji, Y; Shi, Y; Xu, W | 1 |
| Choi, MJ; Ham, SA; Hong, K; Hwang, JS; Lee, GH; Lee, WJ; Lim, DS; Paek, KS; Seo, HG; Yoo, H | 1 |
| Liu, J; Tian, Y; Wang, N; Xiao, L; Xie, X; Yang, C; Yao, Q; Zhang, Z | 1 |
| Ding, J; Gou, Q; Hou, Y; Jin, J; Liu, Q; Shi, J | 1 |
| Cheng, P; Liu, T; Shao, HG; Sun, YC | 1 |
| DuBois, RN; Fu, L; Wang, D; Wei, J; Xiong, Y | 1 |
| El Sheikh, M; Idrees, M; Joo, MD; Kong, IK; Lee, KL; Sidrat, T; Song, SH; Xu, L | 1 |
| Cheng, HS; Hew, ID; Leow, MKS; Phua, WWT; Tan, NS; Tan, WR; Wahli, W; Wee, JWK; Yip, YS | 1 |
| Hirao-Suzuki, M; Koga, T; Takeda, S; Takiguchi, M; Toda, A | 1 |
| Ameline, A; Gheddar, L; Kintz, P; Raul, JS | 1 |
| Adarbes, V; de Muynck, K; Defrêne, E; Devisscher, L; Estivalet, C; Frank, AK; Geerts, A; Guillot, A; Heymann, F; Hundertmark, J; Lefere, S; Penners, C; Puengel, T; Tacke, F; Wettstein, G | 1 |
| Bittard, H; Elie-Caille, C; Fauconnet, S; Lascombe, I; Péchery, A | 1 |
| Amersfoort, J; Bot, I; Chi, H; Douna, H; Foks, AC; Hankemeier, T; Harms, A; Kuiper, J; Moreno-Gordaliza, E; Schaftenaar, FH; Slütter, B; van Puijvelde, GHM; van Santbrink, PJ; Wang, Y | 1 |
| Arima, T; Nakano, Y; Shimizu, A; Takahashi, H; Tobita, Y; Uchiyama, M | 1 |
| Ishii, H; Kasashima, Y; Kawasaki, K; Kijima-Suda, I; Kushiro, A; Leung, GN; Okada, J; Yamada, M; Yamashita, S | 1 |
| Ahrens, B; Sobolevsky, T | 1 |
| Boehler, J; Defour, A; Jahnke, VE; Jaiswal, JK; Johnston, HK; Nagaraju, K; Peterson, JM; Phadke, A; Uaesoontrachoon, K; Van Der Meulen, JH; Yu, Q | 1 |
| Ishii, H; Kasashima, Y; Kawasaki, K; Kijima-Suda, I; Kushiro, A; Leung, GN; Okada, J; Shibuya, M; Yamada, M; Yamashita, S | 1 |
| Astakhova, AA; Chistyakov, DV; Goriainov, SV; Sergeeva, MG | 1 |
| Ishii, H; Kasashima, Y; Kawasaki, K; Kijima-Suda, I; Kushiro, A; Leung, GN; Nozawa, S; Okada, J; Shibuya, M; Yamada, M; Yamashita, S | 1 |
| André, F; Bailly-Chouriberry, L; Boyer, S; Caroff, M; Chabot, B; Delcourt, V; Drif, L; Garcia, P; Haryouli, H; Jaubert, M; Loup, B; Moulard, Y; Popot, MA; Taleb, W; Tendon, S; Trevisiol, S | 1 |
| Hur, J; Hwang, JS; Kang, ES; Kim, E; Lee, HG; Lee, WJ; Seo, HG; Won, JP | 1 |
| Fujii, J; Hur, J; Hwang, JS; Kim, E; Lee, HG; Lee, WJ; Seo, HG; Won, JP | 1 |
16 review(s) available for thiazoles and gw 501516
| Article | Year |
|---|---|
[Activation of "fat burning sensor" peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome].
Topics: Animals; CCAAT-Enhancer-Binding Proteins; DNA-Binding Proteins; Fatty Acids; Glucose Tolerance Test; Humans; Insulin Resistance; Kruppel-Like Transcription Factors; Life Style; Metabolic Syndrome; Mice; Mice, Transgenic; Multigene Family; Muscle, Skeletal; Nuclear Proteins; Oxidation-Reduction; Receptors, Cytoplasmic and Nuclear; Sterol Regulatory Element Binding Protein 1; Thiazoles; Transcription Factors; Transcription, Genetic | 2004 |
Roles of peroxisome proliferator-activated receptor delta (PPARdelta) in the control of fatty acid catabolism. A new target for the treatment of metabolic syndrome.
Topics: Adipose Tissue; Animals; Fatty Acids; Insulin Resistance; Ligands; Macaca mulatta; Metabolic Syndrome; Muscle, Skeletal; Obesity; PPAR delta; Thiazoles | 2004 |
GW-501516 GlaxoSmithKline/Ligand.
Topics: Animals; Fatty Acids; Glucose; Humans; Hypolipidemic Agents; Macaca mulatta; Mice; Mice, Obese; PPAR delta; Structure-Activity Relationship; Thiazoles | 2006 |
[PPAR delta and metabolic syndrome].
Topics: Animals; Metabolic Syndrome; Mice; PPAR delta; Thiazoles | 2006 |
Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta.
Topics: Adenosine Triphosphate; Animals; Fatty Acids; Humans; Lipid Metabolism; Lipoproteins; Muscle, Skeletal; Oxidation-Reduction; PPAR delta; Thiazoles; Up-Regulation | 2007 |
PPAR-beta/delta agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home.
Topics: Animals; Atherosclerosis; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dyslipidemias; Glucose; Humans; Insulin Resistance; Lipoproteins; PPAR delta; PPAR-beta; Propionates; Thiazoles | 2008 |
Roles of PPARs in NAFLD: potential therapeutic targets.
Topics: Clinical Trials as Topic; Fatty Liver; Gene Expression; Humans; Inflammation; Liver; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptors; Thiazoles; Triglycerides | 2012 |
Peroxisome proliferator-activated receptor δ: a multifaceted metabolic player.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Clinical Trials as Topic; Dyslipidemias; Hepatocytes; Humans; Inflammation; Insulin Resistance; Liver; Macrophages; Mice; PPAR delta; Thiazoles | 2013 |
Harnessing the benefits of PPARβ/δ agonists.
Topics: Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Molecular Targeted Therapy; Neoplasms; PPAR delta; PPAR-beta; Rodentia; Thiazoles | 2013 |
New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease.
Topics: Acetates; Animals; Atherosclerosis; Chalcones; Cholesterol, HDL; Dyslipidemias; Fatty Liver; Fenofibrate; Humans; Insulin Resistance; Lipoproteins, HDL; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptors; Propionates; Quinolines; Sulfonamides; Thiazoles; Triazoles; Triglycerides | 2014 |
Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Topics: Aminoimidazole Carboxamide; Animals; Doping in Sports; Exercise; Humans; Physical Endurance; PPAR delta; Ribonucleotides; Thiazoles | 2014 |
Recent Updates on Peroxisome Proliferator-Activated Receptor δ Agonists for the Treatment of Metabolic Syndrome.
Topics: Animals; Humans; Metabolic Syndrome; PPAR delta; Thiazoles | 2016 |
Exercise Pills: At the Starting Line.
Topics: Acetylcarnitine; Animals; Biomimetic Materials; Catechin; Exercise; Fibronectins; Humans; Molecular Targeted Therapy; Pyrrolidines; Resveratrol; Stilbenes; Thiazoles; Thiophenes | 2015 |
Nuclear receptors and AMPK: can exercise mimetics cure diabetes?
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus; Energy Metabolism; Exercise; Exercise Therapy; Fibroblast Growth Factors; Homeostasis; Humans; Insulin Resistance; Liver; Mitochondria; Muscle, Skeletal; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Peroxisome Proliferator-Activated Receptors; Receptors, Cytoplasmic and Nuclear; Sirtuins; Thiazoles | 2016 |
PPAR Agonists, Atherogenic Dyslipidemia and Cardiovascular Risk.
Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Clinical Trials as Topic; Dyslipidemias; Humans; Hypolipidemic Agents; Peroxisome Proliferator-Activated Receptors; Risk Factors; Thiazoles | 2017 |
Antihypertensive effects of peroxisome proliferator-activated receptor-β/δ activation.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Endothelium, Vascular; Fatty Acids; Gene Expression Regulation; Humans; Hypertension; Inflammation; Phenoxyacetates; PPAR delta; PPAR-beta; Rats; Rats, Inbred SHR; RGS Proteins; Sympathetic Nervous System; Thiazoles; Vasoconstriction; Vasodilation | 2017 |
5 trial(s) available for thiazoles and gw 501516
| Article | Year |
|---|---|
Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.
Topics: Adult; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; CD36 Antigens; Cells, Cultured; Fatty Acids; Humans; Lipoproteins, HDL; Male; Muscle, Skeletal; Oxidation-Reduction; PPAR delta; Thiazoles; Triglycerides; Up-Regulation | 2007 |
Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.
Topics: Adenylate Kinase; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; Glucose; Humans; Insulin; Lipid Metabolism; Muscle Cells; Muscle, Skeletal; Oxidation-Reduction; Phosphorylation; PPAR delta; RNA, Small Interfering; Thiazoles | 2007 |
Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.
Topics: Adolescent; Adult; Apolipoproteins B; Cholesterol, HDL; Double-Blind Method; Fatty Acids; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Obesity; Oxidation-Reduction; Oxidative Stress; Placebos; PPAR delta; Thiazoles; Triglycerides | 2008 |
Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity.
Topics: Adult; Apolipoprotein A-I; Apolipoprotein A-II; Apolipoproteins B; Apolipoproteins C; Cholesterol; Cross-Over Studies; Double-Blind Method; Dyslipidemias; Humans; Kinetics; Lipids; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Obesity, Abdominal; PPAR delta; Thiazoles; Triglycerides | 2011 |
Lipid effects of peroxisome proliferator-activated receptor-δ agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome.
Topics: Adult; Analysis of Variance; Apolipoprotein A-I; Apolipoproteins B; Biomarkers; Blood Glucose; Chi-Square Distribution; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Double-Blind Method; Dyslipidemias; Fatty Acids, Nonesterified; Female; Humans; Hypolipidemic Agents; Insulin; Male; Metabolic Syndrome; Middle Aged; PPAR gamma; Thiazoles; Time Factors; Treatment Outcome; Triglycerides | 2012 |
202 other study(ies) available for thiazoles and gw 501516
| Article | Year |
|---|---|
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
Topics: Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Blood Glucose; Cell Line; Cholesterol; Cholesterol, HDL; Drug Design; Fasting; Fibroblasts; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Intestinal Mucosa; Intestines; Macaca mulatta; Macrophages; Male; Metabolic Diseases; Obesity; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Substrate Specificity; Thiazoles; Transcription Factors; Triglycerides | 2001 |
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.
Topics: Animals; Cells, Cultured; Combinatorial Chemistry Techniques; Humans; Mice; Radioligand Assay; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Thiazoles; Transcription Factors; Transcriptional Activation | 2003 |
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Body Weight; Dietary Fats; Energy Metabolism; Fatty Acids; Food, Formulated; Genetic Vectors; Lipid Metabolism; Mice; Mice, Knockout; Mice, Transgenic; Obesity; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Leptin; Recombinant Fusion Proteins; Thiazoles; Transcription Factors; Transgenes; Triglycerides | 2003 |
PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Division; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Liver Neoplasms; Membrane Proteins; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors; Tumor Cells, Cultured | 2003 |
The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells.
Topics: Animals; Base Sequence; Cell Line; Cholesterol; DNA Primers; Energy Metabolism; Gene Expression Regulation; Lipid Metabolism; Mice; Muscle, Skeletal; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transcription Factors; Transfection | 2003 |
A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta.
Topics: Magnetic Resonance Spectroscopy; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors | 2003 |
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.
Topics: Animals; Dimethyl Sulfoxide; Enzymes; Fatty Acids, Nonesterified; Insulin Resistance; Lipid Metabolism; Liver; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; Oxidation-Reduction; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors | 2003 |
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth.
Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Genes, APC; Humans; Intestinal Neoplasms; Intestinal Polyps; Ligands; Mice; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors | 2004 |
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
Topics: Administration, Topical; Animals; Cell Differentiation; Cytokines; Dermatitis; Epidermal Cells; Epidermis; Gene Expression Regulation; Humans; Keratinocytes; Lipid Metabolism; Male; Mice; Mice, Hairless; Permeability; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors; Ultraviolet Rays | 2004 |
Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.
Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Female; Gene Expression; Genes, cdc; Genes, Reporter; Humans; Ligands; Luciferases; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Response Elements; RNA, Messenger; Signal Transduction; Thiazoles; Transcription Factors; Transcriptional Activation | 2004 |
Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Caco-2 Cells; Cholesterol; Cholesterol, HDL; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Macrophages; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred DBA; Mice, Knockout; PPAR delta; Proteins; RNA, Messenger; Sterols; Thiazoles; Time Factors | 2005 |
Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys.
Topics: Animals; Chlorocebus aethiops; Cholesterol, HDL; Male; Particle Size; PPAR alpha; PPAR gamma; Thiazoles | 2005 |
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.
Topics: Adipocytes; Animals; Biological Transport; Cell Line; Cells, Cultured; Fibroblasts; Flavonoids; Gene Expression Regulation; Glucose; Humans; Imidazoles; MAP Kinase Kinase Kinases; Muscle Fibers, Skeletal; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; PPAR delta; Pyridines; Thiazoles | 2005 |
Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Adenosquamous; Carcinoma, Ductal; Carcinoma, Squamous Cell; Cell Differentiation; Disease Progression; Female; Gene Expression Profiling; Mammary Neoplasms, Experimental; Mice; Oxazoles; PPAR delta; PPAR gamma; Thiazoles; Tyrosine | 2005 |
Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.
Topics: Animals; Body Weight; Butyrates; CD36 Antigens; Cholesterol; Coenzyme A Ligases; Eating; Endocannabinoids; Fatty Acid-Binding Proteins; Hepatocytes; Hyperlipidemias; Ion Channels; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Obesity; Oleic Acids; Phenylurea Compounds; PPAR alpha; Pyrimidines; Rats; Rats, Inbred WF; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones; Triglycerides; Uncoupling Protein 2 | 2005 |
Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Ethionine; Liver; Male; Mice; Mice, Inbred C57BL; PPAR alpha; PPAR gamma; Receptors, Cytoplasmic and Nuclear; Stem Cells; Thiazoles; Thiazolidinediones | 2005 |
Differential responses of PPARalpha, PPARdelta, and PPARgamma reporter cell lines to selective PPAR synthetic ligands.
Topics: Anilides; Benzhydryl Compounds; Butyrates; DNA-Binding Proteins; Epoxy Compounds; Genes, Reporter; HeLa Cells; Humans; Inhibitory Concentration 50; Ligands; Luciferases; Peroxisome Proliferator-Activated Receptors; Phenylurea Compounds; PPAR alpha; PPAR delta; PPAR gamma; Rosiglitazone; Saccharomyces cerevisiae Proteins; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection | 2005 |
Activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer-binding protein beta.
Topics: Androstadienes; Carcinoma; CCAAT-Binding Factor; Cell Line, Tumor; Cell Proliferation; Dinoprostone; Dose-Response Relationship, Drug; Enhancer Elements, Genetic; Enzyme Inhibitors; Humans; Kinetics; Lung Neoplasms; Mutation; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; PPAR delta; PPAR-beta; Promoter Regions, Genetic; Receptors, Prostaglandin; RNA, Messenger; RNA, Small Interfering; Thiazoles; Transcription, Genetic; Wortmannin | 2005 |
Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment.
Topics: Adenosine Triphosphate; Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Induction; Fibrinolytic Agents; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ion Channels; Membrane Transport Proteins; Mitochondrial Proteins; Muscle Fibers, Skeletal; Muscular Diseases; Myoblasts, Skeletal; Peroxisome Proliferator-Activated Receptors; Pyrimidines; Rats; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Uncoupling Protein 2 | 2005 |
Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.
Topics: Catalysis; Cell Line; Chemistry, Pharmaceutical; Drug Design; Genes, Reporter; Genetic Techniques; Globins; HeLa Cells; Humans; Hydroxybenzoates; Ligands; Lipids; Models, Chemical; Palladium; PPAR delta; PPAR-beta; Promoter Regions, Genetic; Quinazolines; Thiazoles; Time Factors; Transcription, Genetic; Transcriptional Activation | 2006 |
PPARdelta activator GW-501516 has no acute effect on glucose transport in skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Carrier Proteins; Glucose; Glucose Transporter Type 4; In Vitro Techniques; Ion Channels; Male; Mitochondrial Proteins; Multienzyme Complexes; Muscle Contraction; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR delta; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Uncoupling Protein 3 | 2006 |
Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Catalase; Cell Line; DNA Fragmentation; Hydrogen Peroxide; In Situ Nick-End Labeling; Myoblasts, Cardiac; Oxidative Stress; PPAR delta; Rats; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transfection; Up-Regulation | 2006 |
Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet.
Topics: Acyl-CoA Oxidase; Alanine Transaminase; Animals; Bezafibrate; Carnitine O-Palmitoyltransferase; Cholesterol, HDL; Choline; Diet; Dose-Response Relationship, Drug; Fatty Acid-Binding Proteins; Fatty Liver; Gene Expression; Interleukin-6; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Peroxisome Proliferator-Activated Receptors; PPAR delta; RNA, Messenger; Thiazoles; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta; Transforming Growth Factor beta1; Triglycerides | 2006 |
BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells.
Topics: Animals; Cell Line; Cell Survival; Cytokines; Glucose; Inflammation; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; PPAR delta; Proto-Oncogene Proteins c-bcl-6; Rats; Rats, Wistar; Signal Transduction; Thiazoles | 2006 |
Activation of PPAR-delta in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids.
Topics: AMP-Activated Protein Kinases; Animals; Dietary Carbohydrates; Dietary Fats; Fatty Acids; Food Preferences; Glucose; Insulin; Kinetics; Male; Mitochondria, Muscle; Multienzyme Complexes; Muscle, Skeletal; PPAR delta; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Thiazoles | 2006 |
A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.
Topics: Bile Duct Neoplasms; Blotting, Western; Cell Division; Cholangiocarcinoma; Cyclooxygenase 2; Dinoprostone; Group IV Phospholipases A2; Humans; Immunoprecipitation; Luciferases; Membrane Proteins; Phospholipases A; Phosphorylation; PPAR delta; Protein Binding; Receptors, Prostaglandin E; Recombinant Proteins; Response Elements; Signal Transduction; Thiazoles; Thymidine; Transcriptional Activation; Tumor Cells, Cultured | 2006 |
Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis.
Topics: Aorta, Thoracic; Cell Line; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Gene Expression Regulation; Humans; Neovascularization, Physiologic; PPAR delta; PPAR-beta; Thiazoles; Umbilical Veins; Vascular Endothelial Growth Factor A | 2007 |
Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression.
Topics: Adenoma; Animals; Cell Line, Tumor; Cell Survival; Disease Progression; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Intestinal Neoplasms; Intestinal Polyps; Male; Mice; Mice, Knockout; PPAR delta; Proto-Oncogene Proteins c-akt; Thiazoles; Vascular Endothelial Growth Factor A | 2006 |
Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo.
Topics: Acetates; Animals; Brain; Brain Ischemia; Caspases; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dopamine; Genes, Reporter; Humans; Ligands; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Phenols; Phenoxyacetates; PPAR delta; Rats; Rats, Wistar; Substrate Specificity; Thiazoles | 2007 |
Peroxisome proliferator-activated receptor-delta upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-beta.
Topics: 14-3-3 Proteins; Base Sequence; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Transformed; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Humans; Molecular Sequence Data; PPAR delta; Promoter Regions, Genetic; Thiazoles; Up-Regulation | 2007 |
PPARbeta/delta activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts.
Topics: Angiotensin II; Animals; Collagen Type I; Dose-Response Relationship, Drug; Fibroblasts; Male; Myocardium; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; RNA Interference; Thiazoles | 2007 |
The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition.
Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Carcinoma, Hepatocellular; Humans; Interleukin-6; Liver Neoplasms, Experimental; PPAR delta; Rats; STAT3 Transcription Factor; Thiazoles | 2007 |
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.
Topics: Animals; Binding Sites; Butyrates; Cell Line; Eicosapentaenoic Acid; Humans; Hydrocarbons, Fluorinated; Male; Mice; Models, Molecular; Molecular Structure; Mutagenicity Tests; Phenoxyacetates; Phenylurea Compounds; PPAR delta; Thiazoles | 2007 |
Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen; Fibroblasts; Fibrosis; Humans; Immunohistochemistry; Ligands; Myocytes, Cardiac; Peroxisome Proliferators; PPAR alpha; PPAR delta; PPAR gamma; Pyrimidines; Rats; Rats, Inbred Lew; Rosiglitazone; Thiazoles; Thiazolidinediones; Transduction, Genetic | 2007 |
Design of a partial PPARdelta agonist.
Topics: Butyrates; Drug Design; Models, Molecular; Molecular Structure; Phenylurea Compounds; PPAR delta; Structure-Activity Relationship; Thiazoles | 2007 |
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Polyps; Culture Media, Serum-Free; Cyclooxygenase 2; Humans; Ligands; Liver; Mice; Mice, Inbred C57BL; Phosphorylation; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Thiazoles; Vascular Endothelial Growth Factor A | 2007 |
Expression level and agonist-binding affect the turnover, ubiquitination and complex formation of peroxisome proliferator activated receptor beta.
Topics: Animals; Cell Line; Chromatography, Gel; Humans; Immunoprecipitation; Ligands; Mice; PPAR-beta; Thiazoles; Ubiquitin | 2007 |
The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cell Line; Fatty Acids; Glucose; Glycogen; Insulin; Muscle Fibers, Skeletal; Muscle, Skeletal; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR delta; Rats; RNA-Binding Proteins; Sensitivity and Specificity; Thiazoles; Transcription Factors | 2007 |
Transforming growth factor-beta1 is a molecular target for the peroxisome proliferator-activated receptor delta.
Topics: Animals; Atherosclerosis; Cells, Cultured; Gene Expression Regulation; Inflammation; Ligands; Mice; Muscle, Smooth, Vascular; PPAR delta; Rats; RNA, Messenger; Thiazoles; Transforming Growth Factor beta1; Up-Regulation | 2008 |
Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells.
Topics: Catalase; Cells, Cultured; Endothelial Cells; Humans; Inflammation; Ligands; PPAR delta; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Thioredoxins; Umbilical Veins; Up-Regulation | 2008 |
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.
Topics: Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Gene Expression; Humans; Ligands; PPAR delta; PPAR-beta; Thiazoles; Time Factors | 2008 |
PPARbeta/delta agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-kappaB signals.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Humans; I-kappa B Proteins; Lung Neoplasms; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphatidylinositol 3-Kinases; PPAR delta; PPAR-beta; PTEN Phosphohydrolase; Signal Transduction; Thiazoles; Transcription Factor RelA | 2008 |
Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cytokines; DNA; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Interleukin-6; Lipopolysaccharides; Male; Mice; Mitogen-Activated Protein Kinase 3; NF-kappa B; Peroxisome Proliferator-Activated Receptors; Phosphorylation; PPAR delta; PPAR-beta; Protein Binding; Protein Kinases; Rats; Rats, Zucker; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Thiazoles | 2008 |
PPARdelta increases expression of the human apolipoprotein A-II gene in human liver cells.
Topics: Apolipoprotein A-II; Base Sequence; Binding Sites; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Gene Expression; Humans; Lipid Metabolism; Mutation; PPAR delta; Promoter Regions, Genetic; Protein Binding; Response Elements; Sequence Homology, Nucleic Acid; Thiazoles | 2008 |
Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells.
Topics: Adult; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Endothelial Cells; Enzyme Activation; Epoprostenol; Gene Expression Regulation, Enzymologic; Humans; Iloprost; Indomethacin; Leukocytes, Mononuclear; Male; Middle Aged; Neovascularization, Physiologic; PPAR delta; Regeneration; RNA, Small Interfering; Stem Cells; Thiazoles; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2008 |
Endothelial progenitor cells and angiogenesis join the PPARty.
Topics: Adult; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Endothelial Cells; Enzyme Activation; Epoprostenol; Gene Expression Regulation, Enzymologic; Humans; Iloprost; Indomethacin; Leukocytes, Mononuclear; Male; Middle Aged; Neovascularization, Physiologic; PPAR delta; Regeneration; RNA, Small Interfering; Stem Cells; Thiazoles; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2008 |
AMPK and PPARdelta agonists are exercise mimetics.
Topics: Administration, Oral; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biomimetics; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Muscle, Skeletal; Physical Conditioning, Animal; Physical Endurance; PPAR delta; Protein Serine-Threonine Kinases; Ribonucleotides; Thiazoles | 2008 |
Peroxisome proliferator-activated receptor delta-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium L-glutamate metabolic syndrome mice.
Topics: Animals; Animals, Newborn; Blood Glucose; Cholesterol, HDL; Dyslipidemias; Fatty Acids; Gene Expression; Insulin; Insulin Resistance; Leptin; Metabolic Syndrome; Mice; Mice, Obese; Oxidation-Reduction; PPAR delta; Sodium Glutamate; Thiazoles | 2008 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes.
Topics: Annexin A5; Blotting, Western; Caspase 3; Caspase 7; Cell Line; Cell Proliferation; Flow Cytometry; Humans; Keratinocytes; Ligands; Phosphorylation; Polymerase Chain Reaction; PPAR delta; PPAR-beta; Thiazoles; Tretinoin | 2008 |
Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors.
Topics: Adenoma; Adenoma, Oxyphilic; Carcinoma; Carcinoma, Papillary; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cyclic AMP; Cyclin E; Epithelial Cells; Humans; Immunoblotting; Immunoenzyme Techniques; Oncogene Proteins; Phosphorylation; PPAR delta; Retinoblastoma Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Thiazoles; Thyroid Gland; Thyroid Neoplasms; Thyrotropin; Tissue Array Analysis | 2008 |
Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway.
Topics: Animals; Blood Flow Velocity; Bone Marrow; Cells, Cultured; Corneal Neovascularization; Disease Models, Animal; Endothelial Cells; Female; Hematopoietic Stem Cells; Hindlimb; Humans; Ischemia; Male; Mice; Mice, Knockout; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; PPAR delta; Proto-Oncogene Proteins c-akt; Stem Cell Transplantation; Thiazoles; Vascular Diseases | 2008 |
Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Heat-Shock Proteins; Humans; Lung Neoplasms; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidylinositol 3-Kinases; Phosphorylation; PPAR delta; PPAR-beta; Ribonucleotides; RNA, Small Interfering; Signal Transduction; Thiazoles; Transcription Factors | 2009 |
Small molecules can have big effects on endurance.
Topics: Adaptation, Physiological; Aminoimidazole Carboxamide; Animals; Humans; Mice; Mice, Transgenic; Models, Biological; Muscle, Skeletal; Physical Endurance; PPAR delta; Ribonucleotides; Thiazoles | 2008 |
Are "exercise pills" the answer to the growing problem of physical inactivity?
Topics: Aminoimidazole Carboxamide; Animals; Exercise; Exercise Tolerance; Health Behavior; Humans; Mice; Physical Conditioning, Animal; Ribonucleotides; Thiazoles | 2008 |
The exercise pill--too good to be true?
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Exercise; Humans; Mice; Multienzyme Complexes; Muscle, Skeletal; Physical Conditioning, Animal; Physical Endurance; PPAR delta; Protein Serine-Threonine Kinases; Ribonucleotides; Thiazoles | 2008 |
PPARdelta is a ligand-dependent negative regulator of vitamin D3-induced monocyte differentiation.
Topics: Antigens, CD34; Antigens, Differentiation; Arachidonic Acid; Cell Differentiation; Cell Line; Cholecalciferol; Computational Biology; Databases, Factual; Epoprostenol; Gene Expression Profiling; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Ligands; Monocytes; PPAR delta; Thiazoles; Up-Regulation | 2009 |
Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Topics: Combinatorial Chemistry Techniques; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; Glycolates; Humans; Models, Molecular; Molecular Structure; PPAR delta; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2009 |
On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Bezafibrate; Cell Line, Tumor; Fenofibrate; Fibroblasts; Gemfibrozil; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pioglitazone; PPAR delta; PPAR gamma; Propionates; Thiazoles; Thiazolidinediones; Triazoles | 2009 |
Doping control analysis of emerging drugs in human plasma - identification of GW501516, S-107, JTV-519, and S-40503.
Topics: Chromatography, Liquid; Doping in Sports; Humans; Mass Spectrometry; Molecular Structure; Molecular Weight; Quinolines; Receptors, Androgen; Reproducibility of Results; Ryanodine; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tacrolimus Binding Proteins; Tandem Mass Spectrometry; Thiazepines; Thiazoles | 2009 |
PPARbeta/delta agonist increases the expression of PGE2 receptor subtype EP4 in human lung carcinoma cells.
Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dinoprostone; Electrophoretic Mobility Shift Assay; Humans; Lung Neoplasms; PPAR delta; PPAR-beta; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Thiazoles | 2009 |
Peroxisome proliferator-activated receptor beta stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cells, Cultured; Coronary Vessels; Cyclin-Dependent Kinase 9; Cyclosporine; Enzyme Inhibitors; Heart; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardium; Myocytes, Cardiac; Neovascularization, Physiologic; NFATC Transcription Factors; PPAR-beta; Thiazoles | 2009 |
PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle.
Topics: Animals; Cells, Cultured; Cytokines; Down-Regulation; Humans; Hypoglycemic Agents; Inflammation Mediators; Male; Mice; Middle Aged; Muscle, Skeletal; NF-kappa B; PPAR gamma; Pyrimidines; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcriptional Activation | 2009 |
Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination.
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Astrocytes; Brain; Cells, Cultured; Demyelinating Diseases; Encephalitis; Encephalomyelitis, Autoimmune, Experimental; Glial Fibrillary Acidic Protein; Interferon-gamma; Interleukin-6; Lipopolysaccharides; Microglia; Myelin Basic Protein; Neurofilament Proteins; Nitric Oxide Synthase Type II; PPAR gamma; PPAR-beta; Rats; Thiazoles; Tumor Necrosis Factor-alpha | 2009 |
[Doping in the next generation: wringing extra performance from the genotype].
Topics: Aminoimidazole Carboxamide; Animals; Animals, Genetically Modified; Athletic Performance; Cattle; Doping in Sports; Follistatin; Forecasting; Gene Expression Regulation; Genetic Engineering; Genotype; Germany; Humans; Mice; Myostatin; PPAR delta; Ribonucleotides; Thiazoles | 2009 |
PPARdelta mediates IL15 metabolic actions in myotubes: effects of hyperthermia.
Topics: Animals; Cell Line; Hot Temperature; Interleukin-15; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; PPAR delta; Protein Biosynthesis; Thiazoles | 2009 |
Role of peroxisome proliferator-activated receptor beta/delta in chicken adipogenesis.
Topics: Adipogenesis; Anilides; Animals; Cell Differentiation; Chickens; Chromans; Fatty Acid-Binding Proteins; Oleic Acid; PPAR delta; PPAR gamma; PPAR-beta; Thiazoles; Thiazolidinediones; Troglitazone | 2009 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Dose-Response Relationship, Drug; Female; Humans; Ligands; Mammary Neoplasms, Animal; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; PPAR delta; PPAR-beta; Thiazoles; Time Factors; Tumor Stem Cell Assay | 2010 |
PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha--brief report.
Topics: Animals; Blood Platelets; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Mice; Mice, Knockout; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; PPAR delta; PPAR-beta; Probability; Signal Transduction; Thiazoles | 2009 |
Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice.
Topics: Animals; Cell Line; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Fibers, Skeletal; Muscular Dystrophy, Duchenne; PPAR alpha; PPAR-beta; Sarcolemma; Thiazoles; Utrophin | 2009 |
PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress.
Topics: Animals; Aorta; Apoptosis; Atherosclerosis; Cells, Cultured; Endothelial Cells; Enzyme Activation; Feedback, Physiological; Heat-Shock Proteins; Heme Oxygenase-1; Homeostasis; Humans; Ligands; Mice; Mice, Inbred C57BL; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR delta; RNA, Small Interfering; Thiazoles; Transcription Factors; Transcriptional Activation; Umbilical Veins | 2010 |
Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls.
Topics: Chemical Fractionation; Chromatography, Liquid; Doping in Sports; Humans; PPAR delta; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Thiazoles; Urinalysis | 2010 |
Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine O-Palmitoyltransferase; Cell Line; Cricetinae; Fatty Acids; Gene Expression Regulation; Genes, Mitochondrial; Insulin; Insulin-Secreting Cells; Ion Channels; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Proteins; Oxidation-Reduction; Palmitic Acid; PPAR delta; Protein Kinases; Thiazoles; Uncoupling Protein 2; Up-Regulation | 2010 |
The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta.
Topics: Aldehydes; Animals; Aorta; Calreticulin; Cattle; Endothelium, Vascular; Glucose; Glucose Transporter Type 1; Humans; Hyperglycemia; Lipid Peroxidation; Polymerase Chain Reaction; PPAR delta; Rabbits; RNA; RNA, Messenger; Thiazoles | 2010 |
Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice.
Topics: Animals; Appetite Depressants; Appetite Regulation; Energy Metabolism; Insulin Resistance; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; PPAR alpha; PPAR delta; PPAR gamma; Rosiglitazone; Thiazoles; Thiazolidinediones; Weight Loss | 2010 |
PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.
Topics: Base Sequence; Binding Sites; Cells, Cultured; Gene Expression Regulation; Hormones; Humans; Models, Biological; Molecular Sequence Data; PPAR delta; PPAR-beta; Promoter Regions, Genetic; Protein Binding; Sirtuin 1; Sp1 Transcription Factor; Substrate Specificity; Thiazoles; Transcription, Genetic | 2010 |
Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.
Topics: Analysis of Variance; Animals; Blotting, Western; Carnitine O-Palmitoyltransferase; Cell Line; Cell Nucleus; Electrophoretic Mobility Shift Assay; Epoxy Compounds; Fatty Acids; Humans; Insulin Resistance; Interleukin-6; Mice; Muscle, Skeletal; NF-kappa B; PPAR delta; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfones; Thiazoles; Thiophenes | 2010 |
Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Cyclooxygenase 2; Humans; Peroxisome Proliferator-Activated Receptors; PPAR delta; PPAR gamma; PPAR-beta; RNA, Messenger; Thiazoles; Thiazolidinediones; Vascular Endothelial Growth Factor A | 2011 |
PPARdelta inhibits IL-1beta-stimulated proliferation and migration of vascular smooth muscle cells via up-regulation of IL-1Ra.
Topics: Animals; Cell Cycle; Cyclin-Dependent Kinase 4; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-1beta; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR delta; Rats; Thiazoles; Transcriptional Activation; Up-Regulation | 2010 |
Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516.
Topics: Animals; Chlorocebus aethiops; COS Cells; Humans; PPAR alpha; PPAR delta; Thiazoles; Triazoles | 2010 |
Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis.
Topics: Animals; Cell Polarity; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Interleukin-17; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenoxyacetates; PPAR delta; T-Lymphocytes, Helper-Inducer; Th1 Cells; Thiazoles | 2010 |
Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury.
Topics: Animals; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; DNA Fragmentation; Endothelial Cells; Golgi Apparatus; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Microvessels; PPAR delta; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Up-Regulation | 2010 |
Mass spectrometry-based characterization of new drugs and methods of performance manipulation in doping control analysis.
Topics: Doping in Sports; Humans; Mass Spectrometry; Spectrometry, Mass, Electrospray Ionization; Substance-Related Disorders; Thiazepines; Thiazoles | 2010 |
Oral administration of a PPAR-delta agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers.
Topics: Administration, Oral; Animals; Biological Transport; Blood Glucose; CD36 Antigens; Ceramides; Dietary Fats; Diglycerides; Fatty Acid-Binding Proteins; Female; Glucose Transporter Type 4; Glycolysis; GTPase-Activating Proteins; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle Fibers, Skeletal; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Phosphorylation; PPAR delta; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Thiazoles | 2010 |
Synthesis of isosteric selenium analog of the PPARbeta/delta agonist GW501516 and comparison of biological activity.
Topics: Cell Line; Cell Proliferation; Gene Expression; Humans; Keratinocytes; PPAR delta; PPAR-beta; Selenium; Thiazoles | 2010 |
Transcriptional profiling identifies functional interactions of TGF β and PPAR β/δ signaling: synergistic induction of ANGPTL4 transcription.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Cell Line; Chromatin Immunoprecipitation; Computational Biology; Electrophoretic Mobility Shift Assay; Enhancer Elements, Genetic; Gene Expression Profiling; Humans; Mice; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; PPAR delta; PPAR-beta; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Smad3 Protein; Thiazoles; Transforming Growth Factor beta | 2010 |
Reverse crosstalk of TGFβ and PPARβ/δ signaling identified by transcriptional profiling.
Topics: Cell Differentiation; Cell Line; Co-Repressor Proteins; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Humans; PPAR delta; PPAR-beta; Response Elements; Signal Transduction; Thiazoles; Transcription, Genetic; Transforming Growth Factor beta | 2011 |
PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Cells, Cultured; Dietary Fats; Heart; Humans; Inflammation; Lipids; Mice; Mice, Knockout; Myocardium; PPAR delta; PPAR-beta; Signal Transduction; Thiazoles; Transcription Factor RelA | 2011 |
Synthesis, biological evaluation and molecular modeling of GW 501516 analogues.
Topics: Humans; Hydrogen Bonding; Models, Molecular; Muscle Cells; Muscle, Skeletal; Oleic Acid; Oxidation-Reduction; PPAR delta; Protein Binding; Structure-Activity Relationship; Thiazoles | 2010 |
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.
Topics: Acetylation; Angiopoietin-Like Protein 4; Angiopoietins; Animals; Blotting, Western; Chromatin Immunoprecipitation; E1A-Associated p300 Protein; Gene Knockout Techniques; Histones; Humans; Mass Spectrometry; Mice; p300-CBP Transcription Factors; PPAR delta; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity; Thiazoles; Transcriptional Activation | 2011 |
The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1.
Topics: Acetylation; AMP-Activated Protein Kinases; Cell Line; Humans; NF-kappa B; PPAR delta; PPAR-beta; Sirtuin 1; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2011 |
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
Topics: Animals; Cricetinae; Disease Models, Animal; Ether; Hep G2 Cells; Humans; Hypoglycemic Agents; Male; Mice; Mice, Obese; Oximes; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR delta; PPAR gamma; Structure-Activity Relationship; Thiazoles | 2011 |
Endurance factors improve hippocampal neurogenesis and spatial memory in mice.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Female; Hippocampus; Hypoglycemic Agents; Immunohistochemistry; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Neurogenesis; Physical Conditioning, Animal; PPAR delta; Ribonucleotides; Spatial Behavior; Thiazoles | 2011 |
PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle.
Topics: Animals; Biomarkers; Dietary Fats; Glucose; Glucose Tolerance Test; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Organ Specificity; PPAR delta; Rats; Rats, Wistar; RNA, Messenger; Species Specificity; Thiazoles; Triglycerides | 2011 |
Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells.
Topics: Angiotensin II; Cellular Senescence; DNA Damage; Gene Expression Regulation; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heme Oxygenase-1; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR delta; Reactive Oxygen Species; Superoxide Dismutase; Thiazoles; Thioredoxins; Transcription, Genetic; Up-Regulation | 2011 |
The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.
Topics: AMP-Activated Protein Kinases; Animals; Dietary Fats; Down-Regulation; Fatty Acids; Glucose Tolerance Test; Hypertriglyceridemia; Immunoblotting; Lipids; Liver; Mice; Nuclear Proteins; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidate Phosphatase; Phosphorylation; PPAR alpha; PPAR gamma; PPAR-beta; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles; Trans-Activators; Transcription Factors; Triglycerides | 2011 |
AP1-dependent repression of TGFα-mediated MMP9 upregulation by PPARδ agonists in keratinocytes.
Topics: Binding Sites; Cell Line; Cell Nucleus; Cells, Cultured; Electrophoretic Mobility Shift Assay; Gene Expression; Gene Expression Regulation; Humans; Keratinocytes; Male; Matrix Metalloproteinase 9; Phenoxyacetates; PPAR delta; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Thiazoles; Transcription Factor AP-1; Transforming Growth Factor alpha; Up-Regulation | 2011 |
Activation of peroxisome proliferators-activated receptor δ (PPARδ) promotes blastocyst hatching in mice.
Topics: Anilides; Animals; Benzamides; Blastocyst; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Embryo Implantation; Embryonic Development; Epoprostenol; Female; Intramolecular Oxidoreductases; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; PPAR delta; Pregnancy; Prostaglandins H; Pyridines; Retinoid X Receptors; RNA, Messenger; Thiazoles | 2011 |
The role played by the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) activator, GW501516, in control of fatty acid metabolism: a new potential therapeutic target for treating metabolic syndrome.
Topics: AMP-Activated Protein Kinases; Animals; Fatty Acids; Hypertriglyceridemia; Immunoblotting; Liver; Metabolic Syndrome; Mice; Nuclear Proteins; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidate Phosphatase; Phosphorylation; PPAR alpha; PPAR gamma; PPAR-beta; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles; Trans-Activators; Transcription Factors; Triglycerides | 2011 |
Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet.
Topics: Amides; Aminoimidazole Carboxamide; Anabolic Agents; Anilides; Chromatography, Liquid; Doping in Sports; Humans; Illicit Drugs; Internet; Mass Spectrometry; Polyethylene Glycols; Ribonucleotides; Solvents; Substance Abuse Detection; Thiazoles | 2011 |
In vitro responsiveness of human muscle cell peroxisome proliferator-activated receptor δ reflects donors' insulin sensitivity in vivo.
Topics: Blood Glucose; Body Mass Index; Cells, Cultured; Female; Gene Expression Regulation; Glucose Tolerance Test; Humans; Insulin Resistance; Lipid Metabolism; Male; Muscle Cells; Muscle Fibers, Skeletal; PPAR delta; Regression Analysis; RNA, Messenger; Thiazoles | 2011 |
Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; Animals; Glucose; HSP90 Heat-Shock Proteins; Insulin; Interleukin-6; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Thiazoles | 2011 |
Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Fragmentation; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Inhibitor of Apoptosis Proteins; Oxazoles; PPAR delta; PPAR gamma; Survivin; Thiazoles; Tyrosine | 2012 |
Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks.
Topics: Analysis of Variance; Animals; Cell Proliferation; Endothelial Cells; Heterografts; Hindlimb; Human Umbilical Vein Endothelial Cells; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Ischemia; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Mice, Nude; Monocytes; Muscle Fibers, Skeletal; Muscle, Skeletal; Neovascularization, Physiologic; Phosphorylation; PPAR delta; Receptor, IGF Type 1; Reperfusion Injury; Stem Cell Transplantation; Stem Cells; Thiazoles | 2013 |
Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.
Topics: Animals; Anticarcinogenic Agents; Antigens, Ly; Antineoplastic Agents; Cell Line, Tumor; Genetic Predisposition to Disease; Heterozygote; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oxazoles; Phenotype; PPAR gamma; RNA Interference; Signal Transduction; Thiazoles; Tyrosine | 2012 |
GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice.
Topics: Animals; Chemokine CCL2; Chromatin Immunoprecipitation; Immunoblotting; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Nephritis, Interstitial; NF-kappa B; Polymerase Chain Reaction; PPAR delta; Proteinuria; RNA, Small Interfering; Signal Transduction; Thiazoles; Tumor Necrosis Factor-alpha | 2011 |
Angiopoietin-like 4 regulates epidermal differentiation.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Cell Differentiation; Cells, Cultured; Chromatin Immunoprecipitation; Epidermal Cells; Epidermis; Fluorescent Antibody Technique; Humans; Immunoblotting; Keratinocytes; Mice; Mice, Knockout; PPAR delta; PPAR-beta; Promoter Regions, Genetic; Protein Binding; Protein Precursors; Real-Time Polymerase Chain Reaction; Thiazoles; Transglutaminases | 2011 |
Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516.
Topics: Cells, Cultured; Humans; Hydrocarbons, Fluorinated; Models, Molecular; Muscle Cells; Muscle, Skeletal; PPAR alpha; Protein Binding; Thiazoles | 2011 |
Functional role of PPARδ in corneal epithelial wound healing.
Topics: Animals; Burns, Chemical; Cell Death; Cells, Cultured; Cornea; Cytokines; Epithelium, Corneal; Eye Burns; Humans; Keratitis; Male; PPAR gamma; Rabbits; Rats; Rats, Sprague-Dawley; Sodium Compounds; Thiazoles; Up-Regulation; Wound Healing | 2012 |
The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells.
Topics: Animals; Cell Nucleus; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Insulin Resistance; Interleukin-6; Male; Mice; Mice, Knockout; Phosphorylation; PPAR delta; PPAR-beta; Protein Processing, Post-Translational; Protein Transport; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thiazoles | 2012 |
The PPARδ ligand L-165041 inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ.
Topics: Angiogenesis Inhibitors; Cell Cycle; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Physiologic; Phenoxyacetates; Phosphorylation; PPAR delta; Retinoblastoma Protein; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiazoles; Vascular Endothelial Growth Factor A; Wound Healing | 2012 |
Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production.
Topics: Animals; Cell Membrane; Cells, Cultured; Cellular Senescence; Child; Enzyme Activation; Humans; Keratinocytes; Ligands; Mice; Mice, Hairless; Phosphatidylinositol 3-Kinases; PPAR delta; Protein Transport; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; rac1 GTP-Binding Protein; Signal Transduction; Skin; Superoxides; Thiazoles; Ultraviolet Rays; Up-Regulation | 2012 |
Activation of PPARδ counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells.
Topics: Angiotensin II; Cell Membrane; Cells, Cultured; Gene Expression Regulation; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; PPAR gamma; Protein Transport; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Reactive Oxygen Species; Signal Transduction; Thiazoles | 2012 |
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatic Stellate Cells; Hepatocytes; Kupffer Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Piperazines; PPAR delta; Sulfonamides; Thiazoles | 2012 |
Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.
Topics: Animals; Arteries; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; F-Box Proteins; Forkhead Box Protein O3; Forkhead Transcription Factors; Glucose; Indoles; Large-Conductance Calcium-Activated Potassium Channel beta Subunits; Maleimides; Mice; Microscopy, Video; Muscle Proteins; Muscle, Smooth, Vascular; NADPH Oxidases; Patch-Clamp Techniques; Protein Kinase C; Protein Kinase C beta; Proteolysis; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; SKP Cullin F-Box Protein Ligases; Thiazoles; Vasodilation | 2012 |
Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Cell Line; Cell Membrane; Dactinomycin; Humans; Lipoprotein Lipase; Macrophages; Monocytes; PPAR delta; Thiazoles | 2012 |
Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.
Topics: Amyloid beta-Protein Precursor; Animals; Aorta; Biopterins; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; GTP Cyclohydrolase; Humans; Membrane Glycoproteins; Mice; Mice, Transgenic; Microscopy, Confocal; Mutation; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; PPAR gamma; Prostaglandins; Serine; Superoxide Dismutase; Superoxides; Thiazoles; Vasodilation; Vasodilator Agents | 2012 |
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Topics: Animals; Blotting, Western; Cell Division; Colony-Forming Units Assay; Epoxy Compounds; Fatty Acids; Flow Cytometry; Fluorescent Antibody Technique; Hematopoietic Stem Cells; Immunoprecipitation; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Models, Biological; Nuclear Proteins; Oxidation-Reduction; PPAR delta; Promyelocytic Leukemia Protein; Real-Time Polymerase Chain Reaction; Thiazoles; Transcription Factors; Tumor Suppressor Proteins | 2012 |
PPARδ activation protects endothelial function in diabetic mice.
Topics: Animals; Diabetes Mellitus; Diet, High-Fat; Endothelium; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; PPAR delta; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiazoles | 2012 |
Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine.
Topics: Adult; Chromatography, Liquid; Humans; Male; PPAR delta; Tandem Mass Spectrometry; Thiazoles | 2012 |
PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice.
Topics: Analysis of Variance; Animals; Biopterins; Blood Pressure; Cerebral Cortex; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microvessels; Mutation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Polycomb Repressive Complex 1; PPAR delta; Superoxides; Thiazoles | 2012 |
Upregulation of ski in fibroblast is implicated in the peroxisome proliferator--activated receptor δ-mediated wound healing.
Topics: Animals; Cell Proliferation; Cells, Cultured; Female; Fibroblasts; PPAR delta; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Rats; Rats, Wistar; Skin; Thiazoles; Transcriptional Activation; Up-Regulation; Wound Healing | 2012 |
Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Bexarotene; Blotting, Western; Cell Line; Cells, Cultured; Fatty Acids; Gene Expression; Humans; Lipoprotein Lipase; Male; Mice; Mice, Inbred BALB C; Middle Aged; Muscle Fibers, Skeletal; Oxidation-Reduction; Palmitates; PPAR delta; Rats; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tetrahydronaphthalenes; Thiazoles | 2012 |
Ligand activation of peroxisome proliferator-activated receptor delta suppresses cathepsin B expression in human endothelial cells in a posttranslational manner.
Topics: 3' Untranslated Regions; Base Sequence; Cathepsin B; DEAD-box RNA Helicases; Endothelial Cells; Gene Expression; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Ligands; MicroRNAs; Phenoxyacetates; PPAR delta; Protein Processing, Post-Translational; Ribonuclease III; RNA, Small Interfering; Thiazoles | 2012 |
Synthesis, mass spectrometric characterization, and analysis of the PPARδ agonist GW1516 and its major human metabolites: targets in sports drug testing.
Topics: Chemistry Techniques, Synthetic; Doping in Sports; Humans; Mass Spectrometry; Microsomes, Liver; PPAR delta; Safrole; Sulfones; Thiazoles | 2013 |
Effect of PPARβ/δ agonist on the placentation and embryo-fetal development in rats.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Endometrium; Female; Fetal Development; Male; Maternal Exposure; Organ Size; Placenta; Placentation; PPAR delta; PPAR-beta; Pregnancy; Rats; Rats, Sprague-Dawley; Thiazoles | 2013 |
MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor δ in human monocytes during the inflammatory response.
Topics: Base Sequence; Cells, Cultured; Gene Expression Regulation; HEK293 Cells; Humans; Inflammation; Lipopolysaccharides; Macrophages; Membrane Proteins; MicroRNAs; Molecular Sequence Data; Monocytes; Perilipin-2; PPAR delta; RNA, Messenger; Thiazoles; Up-Regulation | 2013 |
PPARδ agonist GW501516 inhibits PDGF-stimulated pulmonary arterial smooth muscle cell function related to pathological vascular remodeling.
Topics: Cell Differentiation; Cell Movement; Cell Proliferation; Chemokine CCL2; Collagen; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Molecular Targeted Therapy; Myocytes, Smooth Muscle; Neovascularization, Pathologic; Platelet-Derived Growth Factor; PPAR delta; Pulmonary Artery; Thiazoles; Transcriptional Activation; Up-Regulation | 2013 |
PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling.
Topics: Animals; Collagen Type I; Collagen Type III; Dermis; Dual-Specificity Phosphatases; Fibroblasts; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Mice; Mice, Hairless; Mitogen-Activated Protein Kinase Phosphatases; PPAR delta; Primary Cell Culture; Skin Aging; Thiazoles; Ultraviolet Rays | 2013 |
PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation.
Topics: Animals; Carcinogenesis; Carcinoma, Ductal; Epithelium; Female; Gene Expression; Genes, erbB-2; Inflammation; Inflammatory Breast Neoplasms; Mammary Neoplasms, Experimental; Metabolomics; Mice; Mice, Transgenic; Phenotype; PPAR delta; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Receptors, Progesterone; Thiazoles; TOR Serine-Threonine Kinases | 2013 |
HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Gene Expression Regulation, Neoplastic; Hep G2 Cells; HIV-1; Humans; Mitochondria; Models, Biological; Mutant Proteins; Oxygen Consumption; PPAR delta; PPAR-beta; Protein Binding; Protein Kinases; Pyruvate Dehydrogenase Complex; RNA, Messenger; Thiazoles; Transcription, Genetic; Transfection; vpr Gene Products, Human Immunodeficiency Virus | 2013 |
Ligand-activated peroxisome proliferator-activated receptor β/δ modulates human endometrial cancer cell survival.
Topics: Apoptosis; beta Catenin; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endometrial Neoplasms; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Molecular Targeted Therapy; Peroxisome Proliferator-Activated Receptors; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Thiazoles | 2013 |
PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference.
Topics: Cholesterol; Fatty Acids; Glucose; Humans; Insulin; Middle Aged; Mitochondria; Muscle Fibers, Skeletal; Oleic Acid; Oxidation-Reduction; PPAR delta; Substrate Specificity; Thiazoles; Transcriptome | 2014 |
Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice.
Topics: Animals; Anti-Inflammatory Agents; Aortitis; Atherosclerosis; Biomarkers; Blood Glucose; Cholesterol, Dietary; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Inflammation Mediators; Insulin; Insulin Resistance; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR delta; Receptors, LDL; Signal Transduction; Thiazoles; Time Factors | 2014 |
Desnutrin/ATGL activates PPARδ to promote mitochondrial function for insulin secretion in islet β cells.
Topics: Animals; Blood Glucose; Cells, Cultured; Diet, High-Fat; Fatty Acids; Glucose; Glucose Intolerance; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Lipase; Lipolysis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; PPAR delta; RNA, Messenger; Thiazoles | 2013 |
Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor.
Topics: Animals; Apoptosis; Cells, Cultured; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Palmitates; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Receptors, Glucagon; RNA Interference; RNA, Small Interfering; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Up-Regulation | 2014 |
Bioactivity screening and mass spectrometric confirmation for the detection of PPARδ agonists that increase type 1 muscle fibres.
Topics: Actins; Angiopoietin-Like Protein 4; Angiopoietins; Biological Assay; Cell Line, Tumor; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Limit of Detection; Mass Spectrometry; Muscle Fibers, Slow-Twitch; Phenoxyacetates; Polymerase Chain Reaction; PPAR delta; RNA, Messenger; Thiazoles | 2014 |
Peroxisome proliferator activated receptor-δ: the middle child vies for attention.
Topics: Animals; Anti-Inflammatory Agents; Aortitis; Atherosclerosis; Insulin Resistance; Male; PPAR delta; Receptors, LDL; Thiazoles | 2014 |
The PPARβ/δ agonist GW501516 attenuates peritonitis in peritoneal fibrosis via inhibition of TAK1-NFκB pathway in rats.
Topics: Animals; Cells, Cultured; Chemokine CCL2; Dietary Supplements; Disease Models, Animal; Glucose; I-kappa B Kinase; Inflammation; Interleukin-6; Lipopolysaccharides; Male; MAP Kinase Kinase Kinases; Peritoneal Dialysis; Peritoneal Fibrosis; Peritonitis; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Uremia | 2014 |
Evaluation of peroxisome proliferator-activated receptor agonists on interleukin-5-induced eosinophil differentiation.
Topics: Adolescent; Adult; Aged; Butyrates; Cell Differentiation; Dose-Response Relationship, Drug; Eosinophils; Female; Humans; Interleukin-5; Male; Middle Aged; Peroxisome Proliferator-Activated Receptors; Phenylurea Compounds; Rosiglitazone; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Young Adult | 2014 |
Effects of the peroxisome proliferator-activated receptor (PPAR)-δ agonist GW501516 on bone and muscle in ovariectomized rats.
Topics: Absorptiometry, Photon; Animals; Body Composition; Cell Differentiation; Cell Line; Cell Proliferation; Female; Immunoassay; Muscle, Skeletal; Osteoblasts; PPAR delta; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Thiazoles; Tibia | 2014 |
PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells.
Topics: Animals; Autophagy; Cells, Cultured; Endoplasmic Reticulum Stress; Humans; Male; Mice; Mice, Knockout; Myocytes, Cardiac; Palmitates; PPAR delta; PPAR-beta; Thiazoles | 2014 |
Effects of peroxisome proliferator-activated receptor-β/δ on sepsis induced acute lung injury.
Topics: Acute Lung Injury; Animals; Cells, Cultured; Male; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; Sepsis; Thiazoles | 2014 |
Activation of peroxisome proliferator activator receptor delta in mouse impacts lipid composition and placental development at early stage of gestation.
Topics: Animals; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Glycolysis; Lipid Metabolism; MAP Kinase Signaling System; Metabolome; Mice, Transgenic; Patched Receptors; Phosphatidylethanolamines; Placenta; Placentation; Pregnancy; Pregnancy Proteins; Proto-Oncogene Proteins c-akt; Random Allocation; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Thiazoles | 2014 |
Identification of fibronectin binding sites in dermatopontin and their biological function.
Topics: Animals; Binding Sites; Chondroitin Sulfate Proteoglycans; Elastin; Extracellular Matrix Proteins; Fibronectins; Gene Silencing; Homeostasis; Humans; Integrin alpha5beta1; Mice; Microscopy, Fluorescence; Protein Binding; Reactive Oxygen Species; RNA, Small Interfering; Skin; Skin Aging; Thiazoles; Ultraviolet Rays | 2014 |
Activation of peroxisome proliferator-activated receptor δ inhibits angiotensin II-induced activation of matrix metalloproteinase-2 in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Enzyme Activation; Male; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphoinositide-3 Kinase Inhibitors; PPAR delta; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Thiazoles | 2014 |
Peroxisome proliferator-activated receptor δ promotes the progression of posttraumatic osteoarthritis in a mouse model.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Disease Models, Animal; Disease Progression; Glycosaminoglycans; In Vitro Techniques; Menisci, Tibial; Mice; Mice, Inbred Strains; Mice, Knockout; Osteoarthritis, Knee; PPAR delta; Severity of Illness Index; Thiazoles; Wounds and Injuries | 2015 |
Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment.
Topics: Animals; Catalase; Cells, Cultured; Collagen; Delayed-Action Preparations; Diabetes Mellitus; Drug Delivery Systems; Fibroblasts; Glutathione Peroxidase; HEK293 Cells; Humans; Hydrogen Peroxide; Lactic Acid; Male; Mice; Microscopy, Electron, Scanning; Oxidation-Reduction; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; PPAR delta; PPAR-beta; Reactive Oxygen Species; Thiazoles; Wound Healing | 2015 |
Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs.
Topics: Acetylcarnitine; Animals; Animals, Newborn; Carnitine O-Palmitoyltransferase; Cell Death; Cells, Cultured; Cytokines; Down-Regulation; Gene Expression Regulation; Interleukin-6; Myocytes, Cardiac; Oleic Acid; Palmitates; PPAR alpha; PPAR delta; Pyrimidines; Rats, Sprague-Dawley; Thiazoles | 2015 |
Activation of PPARδ signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction.
Topics: Adenosine Triphosphate; Animals; Cell Line; Disease Models, Animal; Energy Metabolism; Exercise Tolerance; Fatty Acids; Heart Failure; Mice, Inbred C57BL; Muscle Strength; Muscle, Skeletal; Myocardial Infarction; Oxidation-Reduction; Physical Endurance; PPAR gamma; Signal Transduction; Thiazoles; Time Factors; Transcription, Genetic; Ventricular Dysfunction, Left; Ventricular Function, Left | 2015 |
PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation.
Topics: 3T3-L1 Cells; Adipocytes; Alkaloids; Animals; CD36 Antigens; Cell Line; Cytokines; Fructose; Glucose Intolerance; Humans; Immunoblotting; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Lipoproteins, LDL; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; PPAR delta; PPAR-beta; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles | 2015 |
PPARδ modulates oxLDL-induced apoptosis of vascular smooth muscle cells through a TGF-β/FAK signaling axis.
Topics: Animals; Apoptosis; Atherosclerosis; Cells, Cultured; Coronary Restenosis; Focal Adhesion Protein-Tyrosine Kinases; Lipoproteins, LDL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR delta; Rats; RNA, Small Interfering; Signal Transduction; Thiazoles; Transforming Growth Factor beta | 2015 |
Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system.
Topics: Adipose Tissue, White; Animals; Fructose; Hepatic Stellate Cells; Inflammation; Insulin Resistance; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; PPAR delta; Renin-Angiotensin System; Thiazoles | 2015 |
Activation of PPAR-δ induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cells.
Topics: Cells, Cultured; Endothelial Cells; Humans; Lipoproteins, VLDL; MicroRNAs; PPAR delta; Receptors, LDL; Thiazoles | 2015 |
A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice.
Topics: Animals; Male; Metabolome; Mice; Muscle Proteins; Performance-Enhancing Substances; Physical Conditioning, Animal; Physical Endurance; PPAR delta; Proteome; Running; Thiazoles | 2015 |
AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; AMP-Activated Protein Kinases; Analysis of Variance; Biphenyl Compounds; Blotting, Western; Carbon-Carbon Double Bond Isomerases; DNA Primers; Enoyl-CoA Hydratase; Gene Expression Regulation; Humans; Macrophages; Microarray Analysis; Mutagenesis, Site-Directed; Oxygen Consumption; Plasmids; PPAR delta; Pyrones; Racemases and Epimerases; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiophenes | 2015 |
Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model.
Topics: Animals; Fatty Acids; Gene Expression Regulation; Glucose; Glucose Transporter Type 2; Liver; Male; Non-alcoholic Fatty Liver Disease; PPAR delta; Rats; Rats, Sprague-Dawley; Sterol Regulatory Element Binding Protein 1; Thiazoles | 2015 |
PPARβ/δ Agonist Provides Neuroprotection by Suppression of IRE1α-Caspase-12-Mediated Endoplasmic Reticulum Stress Pathway in the Rotenone Rat Model of Parkinson's Disease.
Topics: Animals; Apoptosis; Caspase 12; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Endoplasmic Reticulum Stress; Endoribonucleases; Fluorescent Antibody Technique; Male; Motor Activity; Multienzyme Complexes; Neostriatum; Neuroprotection; Parkinson Disease; PPAR delta; PPAR-beta; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Rotenone; Signal Transduction; Thiazoles | 2016 |
Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation.
Topics: Animals; Cell Death; Cell Line; Cell Survival; Dietary Fats, Unsaturated; Gene Expression Regulation, Enzymologic; Mice; Muscle Cells; Muscle, Skeletal; Palmitic Acid; Receptors, Cytoplasmic and Nuclear; Sulfones; Thiazoles; Thiophenes | 2015 |
Peroxisome proliferator-activated receptor δ inhibits Porphyromonas gingivalis lipopolysaccharide-induced activation of matrix metalloproteinase-2 by downregulating NADPH oxidase 4 in human gingival fibroblasts.
Topics: Cells, Cultured; Collagen; Down-Regulation; Enzyme Activation; Fibroblasts; Gingiva; Humans; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Matrix Metalloproteinase 2; NADPH Oxidase 4; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Porphyromonas gingivalis; PPAR delta; Reactive Oxygen Species; RNA, Small Interfering; Sulfones; Thiazoles; Thiophenes | 2016 |
Ligand-activated PPARδ upregulates α-smooth muscle actin expression in human dermal fibroblasts: A potential role for PPARδ in wound healing.
Topics: Actins; Cadherins; Cell Differentiation; Cell Movement; Cells, Cultured; Collagen Type I; Fibroblasts; Fibronectins; Humans; Ligands; PPAR delta; Promoter Regions, Genetic; Response Elements; RNA, Small Interfering; Signal Transduction; Skin; Smad3 Protein; Thiazoles; Transcriptional Activation; Transforming Growth Factor beta; Up-Regulation; Wound Healing | 2015 |
Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Cytoprotection; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Inflammasomes; Inflammation Mediators; Lipopolysaccharides; Liver; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Palmitic Acid; PPAR delta; Signal Transduction; Thiazoles; Time Factors | 2015 |
Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding.
Topics: Binding Sites; Cross-Linking Reagents; DNA; Humans; Ligands; PPAR delta; PPAR-beta; Protein Conformation; Protein Structure, Tertiary; Solutions; Tandem Mass Spectrometry; Thiazoles | 2016 |
Pharmacological Activation of Peroxisome Proliferator-Activated Receptor {Delta} Increases Sphingomyelin Synthase Activity in THP-1 Macrophage-Derived Foam Cell.
Topics: Atherosclerosis; Dose-Response Relationship, Drug; Foam Cells; Humans; Macrophages; Membrane Proteins; Nerve Tissue Proteins; PPAR delta; Sphingomyelins; Thiazoles; Transferases (Other Substituted Phosphate Groups) | 2016 |
Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells.
Topics: Apoptosis; Blotting, Western; Cell Proliferation; Flow Cytometry; Humans; Neoplasm Invasiveness; PPAR delta; PPAR-beta; Reactive Oxygen Species; Thiazoles; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2016 |
PPARδ Modulation by GW501516: An Unsuccessful Exercise Mimetic.
Topics: Exercise; PPAR delta; Running; Thiazoles | 2017 |
Peroxisome proliferator-activated receptor δ improves porcine blastocyst hatching via the regulation of fatty acid oxidation.
Topics: Animals; Blastocyst; Embryonic Development; Fatty Acid-Binding Proteins; Fatty Acids; Gene Expression; Glucose; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; PPAR delta; Swine; Thiazoles | 2017 |
Response to "PPARδ Modulation by GW501516: An Unsuccessful Exercise Mimetic".
Topics: Exercise; PPAR delta; Running; Thiazoles | 2017 |
PPARδ activation protects H9c2 cardiomyoblasts from LPS‑induced apoptosis through the heme oxygenase‑1‑mediated suppression of NF‑κB activation.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Caspase 3; Cell Line; Cell Survival; Heme Oxygenase-1; Lipopolysaccharides; Myoblasts, Cardiac; NF-kappa B; PPAR delta; Rats; Signal Transduction; Thiazoles | 2017 |
Ligand-Dependent Interaction of PPARδ With T-Cell Protein Tyrosine Phosphatase 45 Enhances Insulin Signaling.
Topics: Active Transport, Cell Nucleus; Adipocytes, White; Alternative Splicing; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cells, Cultured; Glucose Intolerance; Hepatocytes; Humans; Insulin Resistance; Male; Mice, Inbred ICR; Muscle Fibers, Skeletal; Obesity; PPAR delta; Protein Multimerization; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Recombinant Fusion Proteins; RNA Interference; Specific Pathogen-Free Organisms; Thiazoles | 2018 |
Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Molecular Structure; PPAR delta; Rats; Structure-Activity Relationship; Thiazoles | 2018 |
Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells.
Topics: Animals; Cells, Cultured; Glutamic Acid; Janus Kinase 2; Lipopolysaccharides; Mice; Microglia; Neuroblastoma; Neurotoxicity Syndromes; PPAR delta; Reactive Oxygen Species; Signal Transduction; STAT1 Transcription Factor; Thiazoles | 2018 |
Ligand-Activated Peroxisome Proliferator-Activated Receptor δ Attenuates Vascular Oxidative Stress by Inhibiting Thrombospondin-1 Expression.
Topics: Animals; Antioxidants; Aorta, Thoracic; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Hydrogen Peroxide; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; PPAR delta; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Thiazoles; Thrombospondin 1; Time Factors; Transfection | 2018 |
Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist.
Topics: Acetates; Administration, Oral; Animals; Binding Sites; Biphenyl Compounds; Crystallography, X-Ray; Drug Design; Half-Life; Humans; Inhibitory Concentration 50; Mice; Microsomes; Molecular Docking Simulation; PPAR delta; Protein Structure, Tertiary; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2018 |
Ligand-activated interaction of PPARδ with c-Myc governs the tumorigenicity of breast cancer.
Topics: A549 Cells; Animals; Breast Neoplasms; Carcinogenesis; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; HEK293 Cells; HeLa Cells; Humans; Ligands; MCF-7 Cells; PC12 Cells; PPAR delta; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Rats; RNA, Small Interfering; Thiazoles | 2018 |
PPARδ agonist enhances colitis-associated colorectal cancer.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Humans; Male; Mice; Mice, Inbred C57BL; PPAR delta; Thiazoles | 2019 |
Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Discovery; Glucose Tolerance Test; Hypoglycemic Agents; Mice; PPAR delta; Receptors, G-Protein-Coupled; Thiazoles | 2019 |
Ligand-activated PPARδ inhibits angiotensin II-stimulated hypertrophy of vascular smooth muscle cells by targeting ROS.
Topics: Angiotensin II; Animals; Cell Enlargement; Cells, Cultured; Hypertrophy; Ligands; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidase 1; PPAR delta; Protein Transport; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; RNA Interference; Thiazoles | 2019 |
PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Insulin Resistance; Mice; PPAR delta; PPAR-beta; Receptor, Insulin; Thiazoles; Tumor Necrosis Factor-alpha | 2019 |
Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery.
Topics: Allografts; Anthracenes; Butyrates; Colforsin; Fatty Liver; Feasibility Studies; Female; Humans; Lipid Metabolism; Liver; Liver Transplantation; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Organ Preservation; Perfusion; Perylene; Pharmaceutical Solutions; Phenylurea Compounds; Reperfusion Injury; Thiazoles; Tissue and Organ Harvesting | 2019 |
PPARβ/δ Agonist GW501516 Inhibits Tumorigenesis and Promotes Apoptosis of the Undifferentiated Nasopharyngeal Carcinoma C666-1 Cells by Regulating miR-206.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Mice; MicroRNAs; Nasopharyngeal Carcinoma; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-bcl-2; Thiazoles | 2019 |
Activation of peroxisome proliferator-activated receptor delta suppresses BACE1 expression by up-regulating SOCS1 in a JAK2/STAT1-dependent manner.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Humans; Janus Kinase 2; STAT1 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Thiazoles; Up-Regulation | 2019 |
PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway.
Topics: Animals; Aorta; Biopterins; Cells, Cultured; Endothelium, Vascular; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; PPAR delta; Sulfones; Tetrahydrofolate Dehydrogenase; Thiazoles; Thiophenes; Thoracic Arteries | 2019 |
Metformin inhibits PPARδ agonist-mediated tumor growth by reducing Glut1 and SLC1A5 expressions of cancer cells.
Topics: Amino Acid Transport System ASC; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Glucose; Glucose Transporter Type 1; Glutamine; Humans; Metformin; Mice; Minor Histocompatibility Antigens; PPAR delta; Thiazoles; Transcription, Genetic; Xenograft Model Antitumor Assays | 2019 |
Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance.
Topics: Adipocytes; Adipose Tissue; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Exosomes; Gene Knockdown Techniques; Hepatocytes; In Vitro Techniques; Insulin Resistance; Macrophages; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle Cells; Obesity; Receptors, Cytoplasmic and Nuclear; Thiazoles | 2019 |
PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis.
Topics: Animals; Colorectal Neoplasms; Diet, High-Fat; Dietary Fats; HCT116 Cells; Humans; Liver Neoplasms, Experimental; Male; Mice, Inbred NOD; Mice, Mutant Strains; Nanog Homeobox Protein; Neoplastic Stem Cells; PPAR delta; Promoter Regions, Genetic; Thiazoles; Xenograft Model Antitumor Assays | 2019 |
The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos.
Topics: Animals; Apoptosis; Carnitine O-Palmitoyltransferase; Cattle; Embryonic Development; Fatty Acids, Nonesterified; Lipid Metabolism; Lipogenesis; Lipolysis; Mitochondria; Muscle, Skeletal; Oxidation-Reduction; Phosphoenolpyruvate Carboxylase; PPAR delta; Thiazoles | 2019 |
PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle.
Topics: Animals; Cytokines; Gene Expression Regulation; Glucocorticoids; HEK293 Cells; Hepatocyte Nuclear Factor 3-beta; Homeostasis; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts; PPAR delta; PPAR-beta; Signal Transduction; Thiazoles; Transcriptional Activation; Up-Regulation | 2020 |
Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation.
Topics: Breast Neoplasms; Cannabinoids; Cyclooxygenase 2; Female; Gene Expression; Humans; PPAR delta; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Transcription Factor AP-1; Tumor Cells, Cultured | 2020 |
Testing for GW501516 (cardarine) in human hair using LC/MS-MS and confirmation by LC/HRMS.
Topics: Chromatography, Liquid; Doping in Sports; Hair; Humans; Male; Mass Spectrometry; Substance Abuse Detection; Tandem Mass Spectrometry; Thiazoles | 2020 |
Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages
Topics: Animals; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Fatty Liver; Fenofibrate; Hypolipidemic Agents; Liver; Liver Cirrhosis; Macrophages; Male; Mice; Peroxisome Proliferator-Activated Receptors; Thiazoles | 2020 |
Molecular and nanoscale evaluation of N-cadherin expression in invasive bladder cancer cells under control conditions or GW501516 exposure.
Topics: Antigens, CD; Cadherins; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Microscopy, Atomic Force; PPAR delta; PPAR-beta; Signal Transduction; Thiazoles; Urinary Bladder Neoplasms | 2020 |
Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells.
Topics: Animals; Atherosclerosis; Cell Movement; Cells, Cultured; Coculture Techniques; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Energy Metabolism; Fatty Acids; Inflammation; Inflammation Mediators; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice, Knockout, ApoE; Oxidation-Reduction; Phenotype; Plaque, Atherosclerotic; PPAR gamma; Receptors, LDL; Signal Transduction; T-Lymphocytes, Regulatory; Thiazoles | 2021 |
Peroxisome Proliferator-Activated Receptor Beta/Delta Agonist Suppresses Inflammation and Promotes Neovascularization.
Topics: Animals; Corneal Injuries; Disease Models, Animal; Gene Expression Regulation; Inflammation; Interleukin-1beta; Interleukin-6; Male; Neovascularization, Physiologic; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Thiazoles; Vascular Endothelial Growth Factor A | 2020 |
Doping control analysis of GW1516 in equine plasma using liquid chromatography/electrospray ionization Q-Exactive high-resolution mass spectrometry.
Topics: Administration, Intranasal; Animals; Chromatography, Liquid; Doping in Sports; Female; Horses; Limit of Detection; Linear Models; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2020 |
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction.
Topics: Anabolic Agents; Anilides; Chromatography, High Pressure Liquid; Clomiphene; Doping in Sports; Humans; Limit of Detection; Selective Estrogen Receptor Modulators; Solid Phase Extraction; Stanozolol; Substance Abuse Detection; Tandem Mass Spectrometry; Thiazoles; Urinalysis | 2021 |
Mitochondrial dysfunction and consequences in calpain-3-deficient muscle.
Topics: Animals; Calpain; Cell Line; Cells, Cultured; Loss of Function Mutation; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscle Proteins; Myoblasts; MyoD Protein; Organelle Biogenesis; PAX7 Transcription Factor; PPAR delta; Thiazoles | 2020 |
Metabolic study of GW1516 in equine urine using liquid chromatography/electrospray ionization Q-Exactive high-resolution mass spectrometry for doping control.
Topics: Animals; Chromatography, High Pressure Liquid; Doping in Sports; Horses; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Thiazoles; Urine | 2021 |
Comparison of PPAR Ligands as Modulators of Resolution of Inflammation, via Their Influence on Cytokines and Oxylipins Release in Astrocytes.
Topics: Anilides; Animals; Anti-Inflammatory Agents; Astrocytes; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fenofibrate; Interleukin-10; Lipopolysaccharides; MAP Kinase Kinase 4; Oxazoles; Oxylipins; p38 Mitogen-Activated Protein Kinases; PPAR gamma; PPAR-beta; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Tumor Necrosis Factor-alpha; Tyrosine | 2020 |
Detection and longitudinal distribution of GW1516 and its metabolites in equine hair for doping control using liquid chromatography/high-resolution mass spectrometry.
Topics: Animals; Chromatography, Liquid; Doping in Sports; Female; Hair; Horses; Performance-Enhancing Substances; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Time Factors | 2021 |
Comprehensive characterization of the peroxisome proliferator activated receptor-δ agonist GW501516 for horse doping control analysis.
Topics: Administration, Oral; Animals; Doping in Sports; Female; Horses; Male; Microsomes, Liver; PPAR delta; Substance Abuse Detection; Thiazoles | 2021 |
Peroxisome proliferator-activated receptor-δ-mediated upregulation of catalase helps to reduce ultraviolet B-induced cellular injury in dermal fibroblasts.
Topics: Catalase; Dermis; Fibroblasts; Humans; Hydrogen Peroxide; Oxidative Stress; Peroxisomes; PPAR delta; Primary Cell Culture; Thiazoles; Ultraviolet Rays; Up-Regulation | 2021 |
Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes.
Topics: Amino Acid Transport System y+; Animals; Catalase; Cells, Cultured; Enzyme Induction; Ferroptosis; Fibroblasts; Hydrogen Peroxide; Lipid Peroxidation; Mice, Knockout; Oxidative Stress; Peroxisomes; PPAR gamma; Signal Transduction; Thiazoles | 2021 |