Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and ge 2270 a

thiazoles has been researched along with ge 2270 a in 52 studies

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's21 (40.38)18.2507
2000's17 (32.69)29.6817
2010's13 (25.00)24.3611
2020's1 (1.92)2.80

Authors

AuthorsStudies
Bandera, M; Denaro, M; Goldstein, BP; Islam, K; Landini, P; Ripamonti, F; Soffientini, A1
Colombo, L; Ferrari, P; Gallo, GG; Kettenring, J; Nebuloni, M; Selva, E; Tavecchia, P; Vékey, K1
Beretta, G; Ferrari, P; Gastaldo, L; Goldstein, BP; Landini, P; Lorenzetti, R; Montanini, N; Ripamonti, F; Saddler, GS; Selva, E1
Anborgh, PH; Parmeggiani, A2
Ciciliato, I; Colombo, L; Ferrari, P; Goldstein, BP; Landini, P; Le Monnier, F; Marinelli, F; Montanini, N; Selva, E; Stella, S1
Colombo, L; Denaro, M; Ferrari, P; Goldstein, BP; Kurz, M; Restelli, E; Ripamonti, F; Selva, E; Stella, S; Tavecchia, P1
Colombo, L; Selva, E; Stella, S1
Arita, M; Hamada, M; Hori, M; Iinuma, H; Ikeno, S; Shimanaka, K; Tsuchiya, KS1
Bonfichi, R; Gentili, P; Kurz, M; Lociuro, S; Selva, E; Sottani, C; Tavecchia, P1
Berti, M; Denaro, M; Goldstein, BP; Resconi, A; Ripamonti, F; Scotti, R1
Bethune, L; King, A; Phillips, I1
Bandera, M; Goldstein, BP; Landini, P; Soffientini, A1
Bartoloni, A; Denaro, M; Goldstein, BP; Mantella, A; Nicoletti, P; Paradisi, F1
Amati, G; Cappellano, C; Donadio, S; Monti, F; Sarubbi, E; Sosio, M1
Abel, K; Hilgenfeld, R; Jurnak, F; Yoder, MD1
Islam, K; Landini, P; Lociuro, S; Marzorati, E; Monti, F; Soffientini, A1
Kraal, B; Möhrle, VG; Tieleman, LN1
Ciabatti, R; Denaro, M; Goldstein, BP; Landini, P; Lociuro, S; Marzorati, E; Tavecchia, P1
Dehb, G; Guerini, O; Polo, S; Sosio, M1
Clough, B; Preiser, PR; Rangachari, K; Strath, M; Wilson, RJ1
Heffron, SE; Jurnak, F1
Hilgenfeld, R; Jurnak, F; Kraal, B; Martien de Graaf, J; Mesters, JR; Mörhle, VG; Olsthoorn-Tieleman, LN; van Duyl, BY; Zuurmond, AM1
De Pietro, MT; Donadio, S; Lancini, G; Marazzi, A; Sosio, M1
Hilgenfeld, R; Hogg, T; Mesters, JR1
Gastaldo, L; Marinelli, F1
Candiani, G; Chen, S; Ciabatti, R; Clough, J; Donadio, S; Gordon, EM; Hackbarth, C; Jacobs, JW; Lam, S; Romanò, G; Trias, J; White, RJ1
Arcari, P; Cantiello, P; Masullo, M1
Anborgh, PH; Okamura, S; Parmeggiani, A1
Bach, T; Heckmann, G1
Krab, IM; Nielsen, RC; Nissen, P; Nyborg, J; Okamura, S; Parmeggiani, A1
Bach, T; Delgado, O; Heckmann, G; Müller, HM1
Chen, DY; Dethe, DH; Li, DB; Nicolaou, KC; Zou, B1
Bibb, MJ; Olsthoorn-Tieleman, LN; Palstra, RJ; Pleij, CW; van Wezel, GP1
Bach, T; Delgado, O; Müller, HM2
Barucco, D; Beltrametti, F; Marinelli, F; Rossi, R; Selva, E1
Chen, DY; Dethe, DH; Leung, GY; Nicolaou, KC; Zou, B1
Dzink-Fox, J; Gunderson, K; Krastel, P; LaMarche, MJ; Leeds, JA; Memmert, K; Patane, MA; Rann, EM; Schmitt, E; Tiamfook, S; Wang, B1
Dzink-Fox, J; LaMarche, MJ; Leeds, JA; Mullin, S; Patane, MA; Rann, EM; Tiamfook, S1
Brewer, JT; Bushell, SM; Deng, G; Dewhurst, JM; Dzink-Fox, J; Gangl, E; Jain, A; LaMarche, MJ; Lee, L; Leeds, JA; Lilly, M; Manni, K; Mullin, S; Neckermann, G; Osborne, C; Palestrant, D; Patane, MA; Raimondi, A; Ranjitkar, S; Rann, EM; Sachdeva, M; Shao, J; Tiamfook, S; Whitehead, L; Yu, D1
Amaral, K; Brewer, JT; Bushell, SM; Dewhurst, JM; Dzink-Fox, J; Gangl, E; Goldovitz, J; Jain, A; LaMarche, MJ; Leeds, JA; Mullin, S; Neckermann, G; Osborne, C; Palestrant, D; Patane, MA; Rann, EM; Sachdeva, M; Shao, J; Tiamfook, S; Whitehead, L; Yu, D1
Alt, S; Brunati, C; Donadio, S; Iorio, M; Maffioli, S; Mazzei, E; Sosio, M; Tocchetti, A1
Grøftehauge, MK; Morth, JP; Nissen, P; Skrydstrup, T; Taaning, R; Therkelsen, MØ1
Apel, AK; Flinspach, K; Kapitzke, C; Sosio, M; Tocchetti, A1
Brandi, L; Donadio, S; Fabbretti, A; Gaspari, E; He, CG; Jabes, D; Maffioli, S; Sosio, M; Spurio, R1
Alt, S; Bordoni, R; Corti, G; Cruz, JC; De Bellis, G; Donadio, S; Gallo, G; Peano, C; Petiti, L; Puglia, AM; Salzano, AM; Scaloni, A; Sosio, M; Tocchetti, A1
Amaike, K; Itami, K; Yamaguchi, J1
Brown, NE; Goldberg, JB; Prezioso, SM1
Cogan, DP; Hudson, GA; Mitchell, DA; Nair, SK; Pogorelov, TV; van der Donk, WA; Zhang, Z1
Baudequin, C; Berini, C; Hédouin, J; Hoarau, C; Lassalas, P; Marsais, F; Rouchet, JEY; Schneider, C1
Chin, EJ; Ching, KC; Kanagasundaram, Y; Leong, CY; Ng, SB; Ng, VW; Seow, DC; Tan, ZY; Wibowo, M; Yang, LK1

Reviews

2 review(s) available for thiazoles and ge 2270 a

ArticleYear
Inhibitory mechanisms of antibiotics targeting elongation factor Tu.
    Current protein & peptide science, 2002, Volume: 3, Issue:1

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Macromolecular Substances; Peptide Elongation Factor Tu; Peptides, Cyclic; Polyenes; Protein Synthesis Inhibitors; Pyridones; Thiazoles

2002
Elfamycins: inhibitors of elongation factor-Tu.
    Molecular microbiology, 2017, Volume: 106, Issue:1

    Topics: Actinomycetales; Actinomycetales Infections; Aminoglycosides; Anti-Bacterial Agents; Drug Design; Escherichia coli; Guanosine Triphosphate; Peptide Elongation Factor Tu; Peptides, Cyclic; Polyenes; Pyridones; Ribosomes; Thiazoles

2017

Other Studies

50 other study(ies) available for thiazoles and ge 2270 a

ArticleYear
Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin.
    The Biochemical journal, 1992, May-01, Volume: 283 ( Pt 3)

    Topics: Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Drug Resistance, Microbial; Escherichia coli; Peptide Biosynthesis; Peptide Elongation Factor Tu; Peptides; Peptides, Cyclic; Poly U; Protein Synthesis Inhibitors; Pyridones; Thiazoles

1992
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.
    The Journal of antibiotics, 1991, Volume: 44, Issue:7

    Topics: Actinomycetales; Amino Acid Sequence; Amino Acids; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Proteins; Chemical Phenomena; Chemistry, Physical; Gas Chromatography-Mass Spectrometry; Gram-Positive Bacteria; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Molecular Weight; Peptides; Peptides, Cyclic; Protein Synthesis Inhibitors; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiazoles

1991
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization.
    The Journal of antibiotics, 1991, Volume: 44, Issue:7

    Topics: Actinomycetales; Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Proteins; Bacteroides fragilis; Gram-Positive Bacteria; Mice; Microbial Sensitivity Tests; Molecular Structure; Moraxella catarrhalis; Mycobacterium tuberculosis; Peptides; Peptides, Cyclic; Propionibacterium acnes; Protein Synthesis Inhibitors; Staphylococcal Infections; Thiazoles

1991
New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu.
    The EMBO journal, 1991, Volume: 10, Issue:4

    Topics: Aminoglycosides; Anti-Bacterial Agents; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Molecular Structure; Peptide Chain Elongation, Translational; Peptide Elongation Factor Tu; Peptides; Peptides, Cyclic; Protein Binding; Ribosomes; Thiazoles

1991
Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization.
    The Journal of antibiotics, 1995, Volume: 48, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Bacteroides fragilis; Chromatography, High Pressure Liquid; Female; Gram-Positive Bacteria; Male; Mice; Microbial Sensitivity Tests; Molecular Structure; Peptides, Cyclic; Rats; Staphylococcal Infections; Streptomyces; Thiazoles

1995
Components of the GE2270 complex produced by Planobispora rosea ATCC 53773.
    The Journal of antibiotics, 1995, Volume: 48, Issue:9

    Topics: Actinomycetales; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Fermentation; Microbial Sensitivity Tests; Molecular Structure; Peptides, Cyclic; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship; Thiazoles

1995
Contribution of mass spectrometry to the structural confirmation of components of the antibiotic GE2270 complex.
    Rapid communications in mass spectrometry : RCM, 1995, Volume: 9, Issue:8

    Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hydrolysis; Molecular Conformation; Peptides; Peptides, Cyclic; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Thiazoles

1995
Novel antibiotics, amythiamicins. IV. A mutation in the elongation factor Tu gene in a resistant mutant of B. subtilis.
    The Journal of antibiotics, 1995, Volume: 48, Issue:2

    Topics: Anti-Bacterial Agents; Bacillus subtilis; Base Sequence; DNA Primers; Drug Resistance, Microbial; Drug Resistance, Multiple; Macrocyclic Compounds; Molecular Sequence Data; Mutation; Peptide Elongation Factor Tu; Peptides, Cyclic; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Thiazoles

1995
Revised structure of the antibiotic GE 2270A.
    The Journal of antibiotics, 1994, Volume: 47, Issue:12

    Topics: Anti-Bacterial Agents; Molecular Structure; Peptides, Cyclic; Spectrometry, Mass, Fast Atom Bombardment; Thiazoles

1994
Probing the reactivity of the GTP- and GDP-bound conformations of elongation factor Tu in complex with the antibiotic GE2270 A.
    The Journal of biological chemistry, 1993, Nov-25, Volume: 268, Issue:33

    Topics: Anti-Bacterial Agents; Escherichia coli; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Diphosphate; Guanosine Triphosphate; Hot Temperature; Mutation; Peptide Elongation Factor Tu; Peptides, Cyclic; Protein Conformation; Protein Denaturation; RNA, Transfer; Thiazoles

1993
In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A).
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:4

    Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic; Staphylococcus; Streptococcus; Thiazoles

1993
In vitro activity of MDL 62,879 (GE2270 A) against aerobic gram-positive and anaerobic bacteria.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:4

    Topics: Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Gram-Positive Bacteria; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic; Thiazoles

1993
Sensitivity of elongation factor Tu (EF-Tu) from different bacterial species to the antibiotics efrotomycin, pulvomycin and MDL 62879.
    Journal of general microbiology, 1993, Volume: 139, Issue:4

    Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Microbial; Gram-Negative Bacteria; Gram-Positive Bacteria; Guanosine Diphosphate; Peptide Elongation Factor Tu; Peptides; Peptides, Cyclic; Pyridones; Species Specificity; Thiazoles

1993
In vitro activity of MDL 62,879 against gram-positive bacteria and Bacteroides species.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1995, Volume: 14, Issue:12

    Topics: Anti-Bacterial Agents; Bacteroides; Clindamycin; Glycopeptides; Gram-Positive Bacteria; Microbial Sensitivity Tests; Penicillins; Peptides, Cyclic; Thiazoles

1995
An elongation factor Tu (EF-Tu) resistant to the EF-Tu inhibitor GE2270 in the producing organism Planobispora rosea.
    Molecular microbiology, 1996, Volume: 22, Issue:1

    Topics: Actinomycetales; Amino Acid Sequence; Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Carrier Proteins; Cloning, Molecular; Conserved Sequence; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Maltose-Binding Proteins; Models, Molecular; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutation; Peptide Elongation Factor Tu; Peptides, Cyclic; Periplasmic Binding Proteins; Pyridones; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thiazoles

1996
An alpha to beta conformational switch in EF-Tu.
    Structure (London, England : 1993), 1996, Oct-15, Volume: 4, Issue:10

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Crystallography, X-Ray; Escherichia coli; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Diphosphate; Guanosine Triphosphate; Peptide Elongation Factor Tu; Peptides, Cyclic; Protein Conformation; Species Specificity; Thiazoles

1996
Antibiotics MDL 62,879 and kirromycin bind to distinct and independent sites of elongation factor Tu (EF-Tu).
    Biochemistry, 1996, Dec-03, Volume: 35, Issue:48

    Topics: Aminoglycosides; Anti-Bacterial Agents; Binding Sites; Chromatography, High Pressure Liquid; Models, Chemical; Peptide Elongation Factor Tu; Peptides; Peptides, Cyclic; Poly U; Pyridones; RNA, Transfer, Amino Acyl; Thiazoles

1996
Elongation factor Tu1 of the antibiotic GE2270A producer Planobispora rosea has an unexpected resistance profile against EF-Tu targeted antibiotics.
    Biochemical and biophysical research communications, 1997, Jan-13, Volume: 230, Issue:2

    Topics: Actinomycetales; Amino Acid Sequence; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Cell-Free System; Cloning, Molecular; Drug Resistance, Microbial; Genes, Bacterial; Kinetics; Molecular Sequence Data; Peptide Biosynthesis; Peptide Elongation Factor Tu; Peptides; Peptides, Cyclic; Protein Biosynthesis; Protein Structure, Secondary; Pyridones; Recombinant Proteins; Sequence Homology, Amino Acid; Streptomyces; Thiazoles

1997
Antimicrobial activities of chemically modified thiazolyl peptide antibiotic MDL 62,879 (GE2270A).
    The Journal of antibiotics, 1997, Volume: 50, Issue:4

    Topics: Acetylation; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Peptide Elongation Factor Tu; Peptides, Cyclic; Structure-Activity Relationship; Thiazoles

1997
Identification of two linear plasmids in the actinomycete Planobispora rosea.
    Microbiology (Reading, England), 1998, Volume: 144 ( Pt 10)

    Topics: Actinomycetales; Base Sequence; Blotting, Southern; Centrifugation, Density Gradient; Chromosomes, Bacterial; Cloning, Molecular; DNA-Binding Proteins; Exodeoxyribonucleases; Molecular Sequence Data; Nucleic Acid Hybridization; Open Reading Frames; Peptides, Cyclic; Plasmids; Polymerase Chain Reaction; Repetitive Sequences, Nucleic Acid; Restriction Mapping; Sequence Homology, Nucleic Acid; Streptomyces; Telomere; Thiazoles; Viral Proteins

1998
Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum.
    Protist, 1999, Volume: 150, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Binding Sites; Genes, Protozoan; Macrocyclic Compounds; Peptide Elongation Factor Tu; Peptides, Cyclic; Plasmodium falciparum; Plastids; Polyenes; Protozoan Proteins; Pyridones; Recombinant Proteins; Thiazoles

1999
Structure of an EF-Tu complex with a thiazolyl peptide antibiotic determined at 2.35 A resolution: atomic basis for GE2270A inhibition of EF-Tu.
    Biochemistry, 2000, Jan-11, Volume: 39, Issue:1

    Topics: Anti-Bacterial Agents; Binding Sites; Crystallization; Crystallography, X-Ray; Drug Resistance, Microbial; Escherichia coli; Models, Molecular; Peptide Elongation Factor Tu; Peptides; Peptides, Cyclic; Protein Conformation; Thiazoles

2000
GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu.GTP.GE2270A complexes.
    Journal of molecular biology, 2000, Dec-15, Volume: 304, Issue:5

    Topics: Actinomycetales; Adenine; Amino Acid Substitution; Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Microbial; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Models, Molecular; Mutation; Peptide Elongation Factor Tu; Peptides; Peptides, Cyclic; Poly U; Protein Binding; Protein Biosynthesis; Protein Conformation; RNA, Bacterial; RNA, Transfer, Amino Acyl; Thermodynamics; Thermus; Thiazoles

2000
Biosynthesis of the thiazolylpeptide antibiotic GE2270.
    The Journal of antibiotics, 2001, Volume: 54, Issue:12

    Topics: Anti-Bacterial Agents; Peptides; Peptides, Cyclic; Thiazoles

2001
Changes in GE2270 antibiotic production in Planobispora rosea through modulation of methylation metabolism.
    Microbiology (Reading, England), 2003, Volume: 149, Issue:Pt 6

    Topics: Actinomycetales; Adenosine; Anti-Bacterial Agents; Culture Media; Drug Interactions; Fermentation; Methionine; Methylation; Molecular Structure; Peptides; Peptides, Cyclic; Thiazoles; Vitamin B 12

2003
Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications.
    Bioorganic & medicinal chemistry letters, 2003, Oct-20, Volume: 13, Issue:20

    Topics: Anti-Bacterial Agents; Biological Products; Combinatorial Chemistry Techniques; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic; Thiazoles

2003
Archaeal elongation factor 1alpha from Sulfolobus solfataricus interacts with the eubacterial antibiotic GE2270A.
    Extremophiles : life under extreme conditions, 2004, Volume: 8, Issue:6

    Topics: Anti-Bacterial Agents; Archaeal Proteins; Escherichia coli; Guanine Nucleotides; Peptide Elongation Factor 1; Peptide Elongation Factor Tu; Peptides, Cyclic; Protein Engineering; Recombinant Proteins; RNA, Bacterial; RNA, Transfer, Phe; Sulfolobus solfataricus; Thiazoles

2004
Effects of the antibiotic pulvomycin on the elongation factor Tu-dependent reactions. Comparison with other antibiotics.
    Biochemistry, 2004, Dec-14, Volume: 43, Issue:49

    Topics: Aminoglycosides; Anti-Bacterial Agents; Binding Sites; Enzyme Inhibitors; Enzyme Stability; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Peptide Elongation Factor Tu; Peptide Elongation Factors; Peptides, Cyclic; Protein Denaturation; Pyridones; Thiazoles; Trypsin; Urea

2004
Synthesis of the heterocyclic core of the GE 2270 antibiotics and structure elucidation of a major degradation product.
    Angewandte Chemie (International ed. in English), 2005, Feb-11, Volume: 44, Issue:8

    Topics: Anti-Bacterial Agents; Heterocyclic Compounds; Magnetic Resonance Spectroscopy; Molecular Structure; Peptides, Cyclic; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiazoles

2005
Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
    Biochemistry, 2006, Jun-06, Volume: 45, Issue:22

    Topics: Aminoglycosides; Anti-Bacterial Agents; Crystallography; Peptide Elongation Factor Tu; Peptides, Cyclic; Phenylalanine-tRNA Ligase; Protein Conformation; Thermus thermophilus; Thiazoles

2006
Synthesis and configurational assignment of the amino alcohol in the eastern fragment of the GE2270 antibiotics by regio- and stereoselective addition of 2-metalated 4-bromothiazoles to alpha-chiral electrophiles.
    The Journal of organic chemistry, 2006, Jun-09, Volume: 71, Issue:12

    Topics: Amino Alcohols; Anti-Bacterial Agents; Molecular Structure; Peptides, Cyclic; Stereoisomerism; Thiazoles

2006
Total synthesis of antibiotics GE2270A and GE2270T.
    Angewandte Chemie (International ed. in English), 2006, Nov-27, Volume: 45, Issue:46

    Topics: Anti-Bacterial Agents; Molecular Structure; Peptides, Cyclic; Thiazoles

2006
Elongation factor Tu3 (EF-Tu3) from the kirromycin producer Streptomyces ramocissimus Is resistant to three classes of EF-Tu-specific inhibitors.
    Journal of bacteriology, 2007, Volume: 189, Issue:9

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Models, Molecular; Peptide Elongation Factor Tu; Peptides, Cyclic; Pyridones; RNA, Bacterial; RNA, Messenger; Streptomyces; Streptomyces coelicolor; Thiazoles; Transcription, Genetic

2007
Total synthesis of the thiazolyl peptide GE2270 A.
    Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:25

    Topics: Anti-Bacterial Agents; Magnetic Resonance Spectroscopy; Molecular Structure; Peptides, Cyclic; Thiazoles

2007
Protoplast fusion and gene recombination in the uncommon Actinomycete Planobispora rosea producing GE2270.
    The Journal of antibiotics, 2007, Volume: 60, Issue:7

    Topics: Actinomycetales; Animals; Anti-Bacterial Agents; Humans; Microbial Sensitivity Tests; Peptides, Cyclic; Protoplasts; Recombination, Genetic; Thiazoles

2007
Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.
    Chemistry, an Asian journal, 2008, Feb-01, Volume: 3, Issue:2

    Topics: Acetamides; Anti-Bacterial Agents; Azoles; Hydroxylation; Macrolides; Molecular Structure; Peptides, Cyclic; Phenylalanine; Pyridines; Sulfhydryl Compounds; Thiazoles

2008
Concise total synthesis of the thiazolyl peptide antibiotic GE2270 A.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2008, Volume: 14, Issue:8

    Topics: Amides; Anti-Bacterial Agents; Cross-Linking Reagents; Lactams; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Peptides, Cyclic; Pyridines; Thiazoles

2008
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
    Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7

    Topics: Anti-Bacterial Agents; Bacteria; Drug Discovery; Drug Stability; Microbial Sensitivity Tests; Peptides, Cyclic; Structure-Activity Relationship; Thiazoles

2011
4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs.
    Bioorganic & medicinal chemistry letters, 2011, Jun-01, Volume: 21, Issue:11

    Topics: Amines; Anti-Bacterial Agents; Copper; Escherichia coli; Gram-Positive Bacteria; Imidazoles; Microbial Sensitivity Tests; Molecular Structure; Peptides, Cyclic; Structure-Activity Relationship; Thiazoles

2011
In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:11

    Topics: Animals; Anti-Bacterial Agents; Cell Line; Cell Survival; Female; Hep G2 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Molecular Structure; Peptide Elongation Factor Tu; Peptides, Cyclic; Staphylococcal Infections; Thiazoles

2011
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
    Journal of medicinal chemistry, 2011, Dec-08, Volume: 54, Issue:23

    Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Carboxylic Acids; Crystallography, X-Ray; Drug Resistance, Bacterial; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Male; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Mutation; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Sepsis; Solubility; Stereoisomerism; Structure-Activity Relationship; Thiazoles

2011
Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270.
    Chemistry & biology, 2013, Aug-22, Volume: 20, Issue:8

    Topics: Actinomycetales; Amino Acid Sequence; Anti-Bacterial Agents; Genes, Fungal; Molecular Sequence Data; Multigene Family; Oxazoles; Peptides, Cyclic; Pyridines; Thiazoles

2013
Identifying ligand-binding hot spots in proteins using brominated fragments.
    Acta crystallographica. Section F, Structural biology and crystallization communications, 2013, Volume: 69, Issue:Pt 9

    Topics: Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Escherichia coli; Gene Expression; Guanosine Triphosphate; Halogenation; Ligands; Mass Spectrometry; Molecular Docking Simulation; Peptide Elongation Factor Tu; Peptide Mapping; Peptides, Cyclic; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; RNA, Transfer; Small Molecule Libraries; Thermus thermophilus; Thiazoles

2013
Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Actinomycetales; Anti-Bacterial Agents; Bacterial Proteins; Cloning, Molecular; Cosmids; Disk Diffusion Antimicrobial Tests; DNA, Ribosomal; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Genes, Bacterial; Molecular Typing; Multigene Family; Peptides, Cyclic; Phylogeny; Promoter Regions, Genetic; RNA, Ribosomal, 16S; Streptomyces coelicolor; Thiazoles; Transcriptional Activation

2014
A Derivative of the Thiopeptide GE2270A Highly Selective against Propionibacterium acnes.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Administration, Topical; Anti-Bacterial Agents; Clindamycin; Drug Resistance, Microbial; Microbial Sensitivity Tests; Peptide Elongation Factor Tu; Peptides, Cyclic; Propionibacterium acnes; Skin; Thiazoles

2015
A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Actinomycetales; Bacterial Proteins; Genome, Bacterial; Genomics; Glucose; High-Throughput Nucleotide Sequencing; Metabolic Networks and Pathways; Multigene Family; Peptides, Cyclic; Proteome; RNA, Bacterial; Sequence Analysis, RNA; Thiazoles; Transcriptome

2015
Synthesis of Triarylpyridines in Thiopeptide Antibiotics by Using a C-H Arylation/Ring-Transformation Strategy.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Mar-18, Volume: 22, Issue:13

    Topics: Anti-Bacterial Agents; Catalysis; Cycloaddition Reaction; Hydrogen Bonding; Nickel; Peptides; Peptides, Cyclic; Pyridines; Thiazoles

2016
Structural insights into enzymatic [4+2]
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 12-05, Volume: 114, Issue:49

    Topics: Actinobacteria; Amino Acid Sequence; Antibiosis; Bacterial Proteins; Binding Sites; Biocatalysis; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Cycloaddition Reaction; Models, Molecular; Peptide Synthases; Peptides, Cyclic; Protein Binding; Thiazoles

2017
Miyaura borylation/Suzuki-Miyaura coupling (MBSC) sequence of 4-bromo-2,4'-bithiazoles with halides: straightforward access to a heterocylic cluster of d-series of thiopeptide GE2270.
    Organic & biomolecular chemistry, 2018, 01-24, Volume: 16, Issue:4

    Topics: Catalysis; Chemistry Techniques, Synthetic; Hydrocarbons, Halogenated; Palladium; Peptides, Cyclic; Stereoisomerism; Thiazoles

2018
Antibacterial Thiopeptide GE2270-Congeners from
    Molecules (Basel, Switzerland), 2022, Dec-23, Volume: 28, Issue:1

    Topics: Actinomycetales; Anti-Bacterial Agents; Humans; Peptides; Thiazoles

2022