Page last updated: 2024-08-21

thiazoles and epothilone b

thiazoles has been researched along with epothilone b in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (26.53)	18.2507
2000's	36 (73.47)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bollag, DM; Goetz, M; Hensens, O; Koupal, L; Lazarides, E; Liesch, J; McQueney, PA; Woods, CM; Zhu, J	1
Bedorf, N; Gerth, K; Höfle, G; Irschik, H; Reichenbach, H	1
Giannakakou, P; Hamel, E; Kowalski, RJ	1
Cowden, CJ; Paterson, I	1
Giannakakou, P; Hamel, E; He, Y; Li, T; Nicolaou, KC; Ninkovic, S; Pastor, J; Sarabia, F; Vourloumis, D; Winssinger, N; Yang, Z	1
Buters, JT; Fojo, T; Giannakakou, P; Kang, YK; Poruchynsky, MS; Sackett, DL; Zhan, Z	1
Muhlradt, PF; Sasse, F	1
Galbiati, F; Horwitz, SB; Lisanti, MP; Volonte, D; Yang, CP	1
Höfle, G; Kiffe, M; Sefkow, M	1
Chakravarty, S; Danishefsky, SJ; He, L; Horwitz, SB; Inoue, T; Kuduk, SD; Lin, S; Ojima, I	1
Finlay, MR; He, Y; Hepworth, D; King, NP; Nicolaou, KC; Ninkovic, S; Roschangar, F; Sarabia, F; Vallberg, H; Vourloumis, D	1
Carney, J; Chung, L; Julien, B; Katz, L; Khosla, C; Shah, S; Tang, L	1
Cyr, DD; Engel, N; Goff, S; Gorlach, J; Hu, A; Ligon, JM; Mayo, JM; Milnamow, M; Molnár, I; Nowak-Thompson, B; Ono, M; Schmid, J; Schupp, T; Stratmann, A; Toupet, C; Zirkle, R	1
Bollbuck, B; Downing, KH; Fojo, T; Giannakakou, P; Gussio, R; Nicolaou, KC; Nogales, E; Poy, G; Sackett, D; Zaharevitz, D	1
Julien, B; Kupfer, D; Roe, B; Santi, DV; Siani, MA	1
Altmann, KH; O'Reilly, T; Wartmann, M	1
Arimoto, H; Danishefsky, SJ; Horwitz, SB; Kaufman, MD; Martello, LA; McDaid, HM; Meng, D; Pettus, TR; Regl, DL; Smith, AB; Yang, CP	1
Botta, M; Hwang, D; Jansen, JM; Kim, Y; Liotta, DC; Snyder, JP; Wang, M; Xia, X	1
Carter, RG; Sundermann, KF; White, JD	1
Goldman, R; Julien, B; Katz, L; Khosla, C; Shah, S; Ziermann, R	1
Bifano, M; DiMarco, J; Fairchild, C; Gougoutas, J; Johnson, J; Kim, SH; Lee, F; Long, B; Tokarski, J; Vite, G	1
Chappell, MD; Danishefsky, SJ; Lee, CB; Stachel, SJ	1
Chappell, MD; Chou, TC; Danishefsky, SJ; He, L; Horwitz, SB; Lee, CB; Stachel, SJ	1
Bigot, A; Bollbuck, B; Finlay, MR; Hepworth, D; King, NP; Nicolaou, KC; Pereira, MM; Scarpelli, R; Werschkun, B; Winssinger, N	1
Altmann, KH; Bollbuck, B; Giannakakou, P; Gussio, R; Nicolaou, KC; Pereira, MM; Scarpelli, R; Wartmann, M; Werschkun, B; Zaharevitz, D	1
Altmann, KH; Bold, G; Caravatti, G; Flörsheimer, A; Guagnano, V; Wartmann, M	1
Aichholz, R; Blum, W; Brüggen, J; Flörsheimer, A; Kühnöl, J; O'Reilly, T; Ramstein, P	1
Gerth, K; Höfle, G; Reichenbach, H; Steinmetz, H	1
Lerner, RA; Miller, GP; Sinha, SC; Sun, J; Wartmann, M	1
Borzilleri, R; Fairchild, CR; Kim, SH; Kramer, RA; Lee, FY; Long, BH; Reventos-Suarez, C; Rose, WC; Vite, GD	1
Carter, RG; Sundermann, KF; Wartmann, M; White, JD	1
Bornmann, WG; Chappell, MD; Chou, TC; Danishefsky, SJ; Guan, Y; Lee, CB; Spassova, M; Stachel, SJ	1
Blagosklonny, MV	1
Kasparian, J; Meurer-Grob, P; Wade, RH	1
Chen, Y; Taylor, RE	1
Bode, JW; Carreira, EM	2
Biswas, K; Danishefsky, SJ; Stachel, SJ	1
Gerth, K; Hardt, IH; Höfle, G; Reichenbach, H; Sasse, F; Steinmetz, H	1
Adler, AJ; Crabtree, DV; Geng, X; Ojima, I	1
Buchmann, B; Bunte, T; Hoffmann, J; Klar, U; Lichtner, RB; Rotgeri, A; Schwede, W; Skuballa, W	1
Hertweck, C	1
Bali, P; Bhalla, K; Fumero, C; Griffin, D; Guo, F; Nimmanapalli, R; O'Bryan, E; Paranawithana, S; Wang, HG; Wittman, S	1
Chen, H; O'Connor, SE; Walsh, CT	1
Katz, L; Li, Y; Qiu, RG; Tang, L	1
Atadja, P; Bali, P; Bhalla, K; Donapaty, S; Fuino, L; Guo, F; Wang, HG; Wittmann, S; Yamaguchi, H	1
Arango, D; Augenlicht, LH; Goldberg, GL; Gross, SJ; Khabele, D; Lopez-Jones, M; Yang, W	1
Kingston, DG	1
Crews, P; Johnson, TA; Sonnenschein, RN; Tenney, K; Valeriote, FA	1

Reviews

3 review(s) available for thiazoles and epothilone b

Article	Year
Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochimica et biophysica acta, 2000, May-17, Volume: 1470, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line; Cell Membrane Permeability; Drug Resistance, Multiple; Drug Tolerance; Epothilones; Epoxy Compounds; Humans; Lactones; Microtubules; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
The epothilones, eleutherobins, and related types of molecules. Current pharmaceutical design, 2001, Volume: 7, Issue:13 Topics: Alkaloids; Animals; Antineoplastic Agents; Diterpenes; Epothilones; Epoxy Compounds; Humans; Structure-Activity Relationship; Thiazoles	2001
The multiplasmid approach: a new perspective for combinatorial biosynthesis. Chembiochem : a European journal of chemical biology, 2000, Aug-18, Volume: 1, Issue:2 Topics: Acyl Coenzyme A; Antineoplastic Agents; Bacterial Proteins; Carrier Proteins; Combinatorial Chemistry Techniques; Epothilones; Epoxy Compounds; Genes, Bacterial; Lactones; Macrolides; Molecular Structure; Multienzyme Complexes; Open Reading Frames; Plasmids; Thiazoles	2000

Other Studies

46 other study(ies) available for thiazoles and epothilone b

Article	Year
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer research, 1995, Jun-01, Volume: 55, Issue:11 Topics: Animals; Binding, Competitive; Calcium; Cattle; Cells, Cultured; Cold Temperature; Colorimetry; Drug Resistance, Multiple; Epothilones; Epoxy Compounds; Filtration; Microtubule Proteins; Microtubules; Paclitaxel; Thiazoles	1995
Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. The Journal of antibiotics, 1996, Volume: 49, Issue:6 Topics: Animals; Antifungal Agents; Epothilones; Epoxy Compounds; Fermentation; Humans; Mice; Microbial Sensitivity Tests; Molecular Structure; Myxococcales; Thiazoles; Tumor Cells, Cultured	1996
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). The Journal of biological chemistry, 1997, Jan-24, Volume: 272, Issue:4 Topics: Drug Resistance, Multiple; Epothilones; Epoxy Compounds; Guanosine Triphosphate; Humans; Kidney; Kinetics; Microtubule-Associated Proteins; Mitotic Index; Paclitaxel; Polymers; Thiazoles; Tubulin; Tumor Cells, Cultured	1997
Synthetic chemistry. Cancer drugs better than taxol? Nature, 1997, May-15, Volume: 387, Issue:6630 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Drug Design; Epothilones; Epoxy Compounds; Paclitaxel; Structure-Activity Relationship; Thiazoles; Tubulin	1997
Synthesis of epothilones A and B in solid and solution phase. Nature, 1997, May-15, Volume: 387, Issue:6630 Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Humans; Solutions; Thiazoles; Tubulin; Tumor Cells, Cultured	1997
Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. The Journal of biological chemistry, 1997, Jul-04, Volume: 272, Issue:27 Topics: Antineoplastic Agents, Phytogenic; Binding Sites; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Female; Humans; Models, Molecular; Nucleic Acid Hybridization; Ovarian Neoplasms; Paclitaxel; Phenotype; Polymerase Chain Reaction; Polymers; Thiazoles; Tubulin; Tumor Cells, Cultured	1997
Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity. Cancer research, 1997, Aug-15, Volume: 57, Issue:16 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Adhesion; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Interferon-gamma; Macrophage Activation; Macrophages; Mice; Microtubules; Nitric Oxide; Paclitaxel; Rotenone; Thiazoles	1997
Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells. FEBS letters, 1998, Nov-20, Volume: 439, Issue:3 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caveolin 1; Caveolins; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Organelles; Paclitaxel; Thiazoles; Tumor Cells, Cultured; Up-Regulation	1998
Derivatization of the C12-C13 functional groups of epothilones A, B and C. Bioorganic & medicinal chemistry letters, 1998, Nov-03, Volume: 8, Issue:21 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Structure-Activity Relationship; Thiazoles	1998
A common pharmacophore for cytotoxic natural products that stabilize microtubules. Proceedings of the National Academy of Sciences of the United States of America, 1999, Apr-13, Volume: 96, Issue:8 Topics: Alkaloids; Alkanes; Antineoplastic Agents, Phytogenic; Carbamates; Computer Graphics; Diterpenes; Epothilones; Epoxy Compounds; Lactones; Magnetic Resonance Spectroscopy; Microtubules; Models, Molecular; Molecular Conformation; Molecular Structure; Paclitaxel; Pyrones; Thiazoles	1999
Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy. Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:5 Topics: Chromatography, Thin Layer; Epothilones; Epoxy Compounds; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Thiazoles	1999
Cloning and heterologous expression of the epothilone gene cluster. Science (New York, N.Y.), 2000, Jan-28, Volume: 287, Issue:5453 Topics: Bacterial Proteins; Cloning, Molecular; Cosmids; Cytochrome P-450 Enzyme System; Epothilones; Epoxy Compounds; Fermentation; Genes, Bacterial; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Myxococcales; Operon; Oxidoreductases; Recombinant Proteins; Streptomyces; Thiazoles; Transformation, Genetic	2000
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. Chemistry & biology, 2000, Volume: 7, Issue:2 Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacterial Proteins; Base Sequence; Cloning, Molecular; Epothilones; Epoxy Compounds; Gene Library; Genes, Bacterial; Macrolides; Microtubules; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Myxococcales; Open Reading Frames; Peptide Synthases; Protein Biosynthesis; Thiazoles	2000
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-14, Volume: 97, Issue:6 Topics: Alkaloids; Antineoplastic Agents; Bridged-Ring Compounds; Diterpenes; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Molecular; Mutation; Paclitaxel; Protein Conformation; Structure-Activity Relationship; Taxoids; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster. Gene, 2000, Apr-18, Volume: 247, Issue:1-2 Topics: Antineoplastic Agents; Bacillus subtilis; Computer Simulation; DNA Probes; DNA, Bacterial; Epothilones; Epoxy Compounds; Genome, Bacterial; Multienzyme Complexes; Multigene Family; Myxococcales; Nucleic Acid Hybridization; Peptide Synthases; Sequence Analysis, DNA; Thiazoles	2000
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:5 Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Carbamates; Cell Count; Cell Division; Cell Line; Cytoskeleton; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epothilones; Epoxy Compounds; Flow Cytometry; Humans; Lactones; Lung Neoplasms; Microtubules; Mitosis; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured	2000
A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone. Organic letters, 1999, Jul-15, Volume: 1, Issue:1 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Magnetic Resonance Spectroscopy; Microtubules; Models, Molecular; Monte Carlo Method; Paclitaxel; Protein Binding; Receptors, Drug; Structure-Activity Relationship; Thiazoles; Tubulin	1999
Improved synthesis of epothilone B employing alkylation of an alkyne for assembly of subunits. Organic letters, 1999, Nov-04, Volume: 1, Issue:9 Topics: Alkylation; Alkynes; Antineoplastic Agents; Epothilones; Epoxy Compounds; Thiazoles	1999
Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. Gene, 2000, May-16, Volume: 249, Issue:1-2 Topics: Amino Acid Sequence; Bacterial Proteins; Cytochrome P-450 Enzyme System; DNA; Epothilones; Epoxy Compounds; Genes, Bacterial; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Myxococcales; Oxidoreductases; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thiazoles	2000
Synthesis, structure proof, and biological activity of epothilone cyclopropanes. Organic letters, 2000, Jun-01, Volume: 2, Issue:11 Topics: Antineoplastic Agents; Cell Survival; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Lactones; Models, Molecular; Molecular Structure; Thermodynamics; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B. Organic letters, 2000, Jun-01, Volume: 2, Issue:11 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Lactones; Thiazoles	2000
On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. Organic letters, 2000, Jun-01, Volume: 2, Issue:11 Topics: Antineoplastic Agents; Aza Compounds; Cell Survival; Epothilones; Epoxy Compounds; Humans; Lactones; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues. Chemistry (Weinheim an der Bergstrasse, Germany), 2000, Aug-04, Volume: 6, Issue:15 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Indicators and Reagents; Molecular Conformation; Molecular Structure; Structure-Activity Relationship; Thiazoles	2000
Chemical synthesis and biological properties of pyridine epothilones. Chemistry & biology, 2000, Volume: 7, Issue:8 Topics: Antineoplastic Agents; Cell Division; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Macrolides; Models, Molecular; Molecular Structure; Pyridines; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
Synthesis and biological evaluation of highly potent analogues of epothilones B and D. Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24 Topics: Antineoplastic Agents; Cell Division; Drug Resistance; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Paclitaxel; Stereoisomerism; Thiazoles; Tumor Cells, Cultured	2000
In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2001, Volume: 15, Issue:1 Topics: Animals; Antineoplastic Agents; Biotransformation; Chromatography, High Pressure Liquid; Epothilones; Epoxy Compounds; Female; Humans; Liver; Mass Spectrometry; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Thiazoles	2001
Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase. The Journal of antibiotics, 2001, Volume: 54, Issue:2 Topics: Binding Sites; Epothilones; Epoxy Compounds; Multienzyme Complexes; Mutation; Oxygenases; Proteobacteria; Thiazoles	2001
Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F. Chemistry (Weinheim an der Bergstrasse, Germany), 2001, Apr-17, Volume: 7, Issue:8 Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antibodies, Catalytic; Antineoplastic Agents; Epothilones; Epoxy Compounds; Fructose-Bisphosphate Aldolase; Haptens; Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Myxococcales; Stereoisomerism; Thiazoles	2001
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:5 Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Survival; Colonic Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Female; Humans; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Sarcoma; Thiazoles; Tubulin; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays	2001
Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D. Journal of the American Chemical Society, 2001, Jun-13, Volume: 123, Issue:23 Topics: Animals; Antineoplastic Agents; Cell Division; Epothilones; Epoxy Compounds; Humans; Macrolides; Swine; Thiazoles; Tubulin; Tumor Cells, Cultured	2001
On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones. The Journal of organic chemistry, 2001, Jun-15, Volume: 66, Issue:12 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Humans; K562 Cells; Mice; Mice, Nude; Neoplasm Transplantation; Spectrum Analysis; Thiazoles	2001
Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells. Leukemia, 2001, Volume: 15, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Boronic Acids; Bortezomib; Cell Cycle; Cell Survival; Cyclosporins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Flavonoids; Hematopoietic Stem Cells; HL-60 Cells; Humans; Jurkat Cells; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Oligopeptides; Paclitaxel; Piperidines; Poly(ADP-ribose) Polymerases; Pyrazines; Substrate Specificity; Thiazoles	2001
Microtubule structure at improved resolution. Biochemistry, 2001, Jul-10, Volume: 40, Issue:27 Topics: Actin Cytoskeleton; Alkaloids; Amino Acid Sequence; Animals; Dimerization; Diterpenes; Docetaxel; Epothilones; Epoxy Compounds; Excipients; Guanosine Triphosphate; Microtubules; Molecular Sequence Data; Paclitaxel; Protein Conformation; Surface Properties; Swine; Taxoids; Thiazoles; Tubulin	2001
Total synthesis of epothilones B and D. Organic letters, 2001, Jul-12, Volume: 3, Issue:14 Topics: Alkenes; Biological Factors; Catalysis; Epothilones; Epoxy Compounds; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Thiazoles	2001
Stereoselective syntheses of epothilones A and B via directed nitrile oxide cycloaddition. Journal of the American Chemical Society, 2001, Apr-18, Volume: 123, Issue:15 Topics: Antineoplastic Agents; Cyclization; Epothilones; Epoxy Compounds; Molecular Conformation; Nitric Oxide; Thiazoles	2001
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. Journal of natural products, 2001, Volume: 64, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Line; Chromatography, High Pressure Liquid; Epothilones; Epoxy Compounds; Fibroblasts; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Myxococcales; Structure-Activity Relationship; Thiazoles	2001
Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:8 Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Carbamates; Carotenoids; Diterpenes; Epothilones; Epoxy Compounds; Haplorhini; Humans; Lactones; Ligands; Lutein; Models, Molecular; Molecular Sequence Data; Paclitaxel; Pyrones; Retina; Thiazoles; Tubulin	2001
Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies. The Journal of organic chemistry, 2001, Sep-21, Volume: 66, Issue:19 Topics: Aldehydes; Antineoplastic Agents; Cyclization; Epothilones; Epoxy Compounds; Molecular Conformation; Nitric Oxide; Thiazoles	2001
Subcellular distribution of epothilones in human tumor cells. Proceedings of the National Academy of Sciences of the United States of America, 2001, Sep-25, Volume: 98, Issue:20 Topics: Antineoplastic Agents, Phytogenic; Cell Division; Cell Line; Epothilones; Epoxy Compounds; Humans; Kinetics; Macrolides; Paclitaxel; Thiazoles; Tumor Cells, Cultured; Verapamil	2001
Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis. Blood, 2002, May-01, Volume: 99, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Drug Synergism; Epothilones; Epoxy Compounds; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Macrolides; Membrane Glycoproteins; Mitochondrial Proteins; Peptide Fragments; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha	2002
Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces. Biochemistry, 2002, Apr-30, Volume: 41, Issue:17 Topics: Acrylates; Acyl Carrier Protein; Acyltransferases; Alcohol Oxidoreductases; Antineoplastic Agents; Bacterial Proteins; Epothilones; Escherichia coli; Hydro-Lyases; Macrolides; Multienzyme Complexes; Peptide Synthases; Protein Structure, Tertiary; Proteins; Thiazoles	2002
Generation of novel epothilone analogs with cytotoxic activity by biotransformation. The Journal of antibiotics, 2003, Volume: 56, Issue:1 Topics: Actinomycetales; Animals; Antineoplastic Agents; Biotransformation; Cell Division; Epothilones; Humans; Macrolides; Molecular Conformation; Thiazoles; Tumor Cells, Cultured	2003
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B. Molecular cancer therapeutics, 2003, Volume: 2, Issue:10 Topics: Annexin A5; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chromatin; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Deoxycytidine; Detergents; Docetaxel; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epothilones; Flow Cytometry; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Multienzyme Complexes; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Sepharose; Taxoids; Tetrazolium Salts; Thiazoles; Time Factors; Trastuzumab	2003
Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer. Gynecologic oncology, 2004, Volume: 93, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Epothilones; Female; Flow Cytometry; Fluorescent Antibody Technique; G2 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Metallothionein; Mitosis; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha; Up-Regulation	2004
What makes epothilones stick? Chemistry & biology, 2004, Volume: 11, Issue:2 Topics: Epothilones; Molecular Conformation; Pyridines; Structure-Activity Relationship; Thiazoles	2004
A reassignment of (-)-mycothiazole and the isolation of a related diol. Journal of natural products, 2006, Volume: 69, Issue:1 Topics: Alcohols; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Drug Screening Assays, Antitumor; Epothilones; Molecular Structure; Polyketide Synthases; Porifera; Stereoisomerism; Thiazoles; Thiazolidines; Vanuatu	2006