Page last updated: 2024-08-21

thiazoles and epothilone a

thiazoles has been researched along with epothilone a in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	26 (28.57)	18.2507
2000's	56 (61.54)	29.6817
2010's	8 (8.79)	24.3611
2020's	1 (1.10)	2.80

Authors

Authors	Studies
Bollag, DM; Goetz, M; Hensens, O; Koupal, L; Lazarides, E; Liesch, J; McQueney, PA; Woods, CM; Zhu, J	1
Bedorf, N; Gerth, K; Höfle, G; Irschik, H; Reichenbach, H	1
Service, RF	1
Mann, J	1
Giannakakou, P; Hamel, E; Kowalski, RJ	1
Cowden, CJ; Paterson, I	1
Giannakakou, P; Hamel, E; He, Y; Li, T; Nicolaou, KC; Ninkovic, S; Pastor, J; Sarabia, F; Vourloumis, D; Winssinger, N; Yang, Z	1
Buters, JT; Fojo, T; Giannakakou, P; Kang, YK; Poruchynsky, MS; Sackett, DL; Zhan, Z	1
Muhlradt, PF; Sasse, F	1
Balog, A; Danishefsky, SJ; Kohl, NE; Moasser, MM; Oliff, A; Rosen, N; Sepp-Lorenzino, L; Su, DS	1
Matthews, I; Schneider, T; Taraschi, TF; Trelka, D	1
Finney, NS	1
Finlay, MR; He, Y; King, NP; Li, T; Nicolaou, KC; Ninkovic, S; Sarabia, F; Vourloumis, D	1
Balog, A; Bertino, JR; Chou, TC; Danishefsky, SJ; Meng, D; Savin, K; Su, DS; Zhang, XG	1
Barbas, CF; Lerner, RA; Sinha, SC	1
Galbiati, F; Horwitz, SB; Lisanti, MP; Volonte, D; Yang, CP	1
Balog, A; Bertino, JR; Chou, TC; Danishefsky, SJ; Harris, CR; Kuduk, SD; Savin, KA; Zhang, XG	1
Höfle, G; Kiffe, M; Schummer, D; Sefkow, M	1
Höfle, G; Kiffe, M; Sefkow, M	1
Altenbuchner, J; Bornscheuer, UT; Meyer, HH	1
Chakravarty, S; Danishefsky, SJ; He, L; Horwitz, SB; Inoue, T; Kuduk, SD; Lin, S; Ojima, I	1
Hamel, E; Nicolaou, KC; Sackett, DL; Vourloumis, D	1
Finlay, MR; He, Y; Hepworth, D; King, NP; Nicolaou, KC; Ninkovic, S; Roschangar, F; Sarabia, F; Vallberg, H; Vourloumis, D	1
Carney, J; Chung, L; Julien, B; Katz, L; Khosla, C; Shah, S; Tang, L	1
Cyr, DD; Engel, N; Goff, S; Gorlach, J; Hu, A; Ligon, JM; Mayo, JM; Milnamow, M; Molnár, I; Nowak-Thompson, B; Ono, M; Schmid, J; Schupp, T; Stratmann, A; Toupet, C; Zirkle, R	1
Bollbuck, B; Downing, KH; Fojo, T; Giannakakou, P; Gussio, R; Nicolaou, KC; Nogales, E; Poy, G; Sackett, D; Zaharevitz, D	1
Julien, B; Kupfer, D; Roe, B; Santi, DV; Siani, MA	1
Altmann, KH; O'Reilly, T; Wartmann, M	1
Arimoto, H; Danishefsky, SJ; Horwitz, SB; Kaufman, MD; Martello, LA; McDaid, HM; Meng, D; Pettus, TR; Regl, DL; Smith, AB; Yang, CP	1
Botta, M; Hwang, D; Jansen, JM; Kim, Y; Liotta, DC; Snyder, JP; Wang, M; Xia, X	1
Carter, RG; Sundermann, KF; White, JD	1
Goldman, R; Julien, B; Katz, L; Khosla, C; Shah, S; Ziermann, R	1
Barbas, CF; Lerner, RA; Miller, G; Sinha, SC; Sun, J	1
Bifano, M; DiMarco, J; Fairchild, C; Gougoutas, J; Johnson, J; Kim, SH; Lee, F; Long, B; Tokarski, J; Vite, G	1
Chappell, MD; Danishefsky, SJ; Lee, CB; Stachel, SJ	1
Chappell, MD; Chou, TC; Danishefsky, SJ; He, L; Horwitz, SB; Lee, CB; Stachel, SJ	1
Bigot, A; Bollbuck, B; Finlay, MR; Hepworth, D; King, NP; Nicolaou, KC; Pereira, MM; Scarpelli, R; Werschkun, B; Winssinger, N	1
Panek, JS; Zhu, B	1
Altmann, KH; Bollbuck, B; Giannakakou, P; Gussio, R; Nicolaou, KC; Pereira, MM; Scarpelli, R; Wartmann, M; Werschkun, B; Zaharevitz, D	1
Chappell, MD; Chou, TC; Danishefsky, SJ; Kuduk, SD; Lee, CB; Stachel, SJ; Wang, ZG; Zhang, XG	1
Mantoulidis, A; Mulzer, J; Ohler, E	1
Altmann, KH; Bold, G; Caravatti, G; Flörsheimer, A; Guagnano, V; Wartmann, M	1
Aichholz, R; Blum, W; Brüggen, J; Flörsheimer, A; Kühnöl, J; O'Reilly, T; Ramstein, P	1
Gerth, K; Höfle, G; Reichenbach, H; Steinmetz, H	1
Lerner, RA; Miller, GP; Sinha, SC; Sun, J; Wartmann, M	1
Borzilleri, R; Fairchild, CR; Kim, SH; Kramer, RA; Lee, FY; Long, BH; Reventos-Suarez, C; Rose, WC; Vite, GD	1
Carter, RG; Sundermann, KF; Wartmann, M; White, JD	1
Bornmann, WG; Chappell, MD; Chou, TC; Danishefsky, SJ; Guan, Y; Lee, CB; Spassova, M; Stachel, SJ	1
Blagosklonny, MV	1
Kasparian, J; Meurer-Grob, P; Wade, RH	1
Chou, TC; Danishefsky, SJ; Guan, Y; Lee, C; O'Connor, OA; Stachel, SJ; Tong, WP; Zhang, ZG	1
Chen, Y; Taylor, RE	1
Chappell, MD; Chou, TC; Danishefsky, SJ; Guan, Y; Lee, CB; Stachel, SJ; Wu, Z; Zhang, F	1
Bode, JW; Carreira, EM	2
Biswas, K; Danishefsky, SJ; Stachel, SJ	1
Gerth, K; Hardt, IH; Höfle, G; Reichenbach, H; Sasse, F; Steinmetz, H	1
Adler, AJ; Crabtree, DV; Geng, X; Ojima, I	1
Buchmann, B; Bunte, T; Hoffmann, J; Klar, U; Lichtner, RB; Rotgeri, A; Schwede, W; Skuballa, W	1
Cheson, BD; Colevas, AD; West, PJ	1
Bhalla, KN; Huang, Z; Lee, MW; Paranawithana, SR; Wang, HG; Yamaguchi, H	1
Hertweck, C	1
Fojo, T; Giannakakou, P; Gussio, R; Hensler, A; Li, J; Namoto, K; Nicolaou, KC; Ritzén, A; Sackett, DL; Shoji, M; Ulven, T; Ward, RD; Zaharevitz, D	1
Lerner, RA; Sinha, SC; Sun, J; Wartmann, M	1
Sundermann, KF; Wartmann, M; White, JD	1
Frykman, S; Lau, J; Licari, P; Ou, S; Regentin, R; Tsuruta, H	1
Bali, P; Bhalla, K; Fumero, C; Griffin, D; Guo, F; Nimmanapalli, R; O'Bryan, E; Paranawithana, S; Wang, HG; Wittman, S	1
Chen, H; O'Connor, SE; Walsh, CT	1
Arslanian, RL; Lau, J; Licari, PJ; McIntire, JR; Parker, CD; Starks, C; Wang, PK	1
Arslanian, RL; Blough, S; Carney, JR; Katz, L; Ma, W; Qiu, RG; Tang, L	1
Biswas, K; Chappell, MD; Chou, TC; Danishefsky, SJ; Guan, Y; He, L; Horwitz, SB; Lin, H; Njardarson, JT; Tong, WP	1
Biswas, K; Danishefsky, SJ; Njardarson, JT	1
Katz, L; Li, Y; Qiu, RG; Tang, L	1
Schneider, TL; Shen, B; Walsh, CT	1
Atadja, P; Bali, P; Bhalla, K; Donapaty, S; Fuino, L; Guo, F; Wang, HG; Wittmann, S; Yamaguchi, H	1
Arango, D; Augenlicht, LH; Goldberg, GL; Gross, SJ; Khabele, D; Lopez-Jones, M; Yang, W	1
Kingston, DG	1
Carney, JR; Kennedy, J; Liu, Y; Mutka, SC	1
Crews, P; Johnson, TA; Sonnenschein, RN; Tenney, K; Valeriote, FA	1
Hearn, BR; Li, Y; Myles, DC; Zhang, D	1
Altmann, KH	1
Ahmed, K; Hori, A; Ishihara, K; Kawaguchi, T; Kobayashi, Y; Kondo, T; Matsuya, Y; Nemoto, H; Watanabe, Y; Wei, ZL; Yu, DY; Zhao, QL	1
Lozynski, M; Pawlak, R; Rusinska-Roszak, D; Tatka, H	1
Corey, SJ; Park, BJ; Whichard, ZL	1
Herbolsheimer, P; Jelinek, J; Kapoor, R; Perry, D; Smith, KL; Swain, SM; Verma, N; Veytsman, I	1
Gleave, ME; Loriot, Y; Zoubeidi, A	1
Chang, AY; Wang, M	1
Deng, K; Katz, L; Keasling, JD; Petzold, CJ; Phelan, RM; Poust, S	1
Bakota, L; Ballatore, C; Brandt, R; Ghori, A; Golovyashkina, N; Niewidok, B; Penazzi, L; Selle, K; Smith, AB; Tackenberg, C	1
Croft, AK; Dowling, DP; Drennan, CL; Kelly, WL; Kung, Y; Taghizadeh, K; Walsh, CT	1
Akhmanova, A; Gao, L; Heise, C; Meiring, JCM; Müller-Deku, A; Rai, A; Thorn-Seshold, J; Thorn-Seshold, O	1

Reviews

5 review(s) available for thiazoles and epothilone a

Article	Year
Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. Chemistry & biology, 1998, Volume: 5, Issue:4 Topics: Antibodies, Catalytic; Antihypertensive Agents; Antineoplastic Agents; Catalysis; Diltiazem; Epothilones; Epoxy Compounds; Hydrolysis; Immunosuppressive Agents; Tacrolimus; Thiazoles	1998
Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochimica et biophysica acta, 2000, May-17, Volume: 1470, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line; Cell Membrane Permeability; Drug Resistance, Multiple; Drug Tolerance; Epothilones; Epoxy Compounds; Humans; Lactones; Microtubules; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
The epothilones, eleutherobins, and related types of molecules. Current pharmaceutical design, 2001, Volume: 7, Issue:13 Topics: Alkaloids; Animals; Antineoplastic Agents; Diterpenes; Epothilones; Epoxy Compounds; Humans; Structure-Activity Relationship; Thiazoles	2001
The multiplasmid approach: a new perspective for combinatorial biosynthesis. Chembiochem : a European journal of chemical biology, 2000, Aug-18, Volume: 1, Issue:2 Topics: Acyl Coenzyme A; Antineoplastic Agents; Bacterial Proteins; Carrier Proteins; Combinatorial Chemistry Techniques; Epothilones; Epoxy Compounds; Genes, Bacterial; Lactones; Macrolides; Molecular Structure; Multienzyme Complexes; Open Reading Frames; Plasmids; Thiazoles	2000
Targeted therapies in metastatic castration-resistant prostate cancer: beyond the androgen receptor. The Urologic clinics of North America, 2012, Volume: 39, Issue:4 Topics: Bone Neoplasms; Cell Proliferation; Cell Survival; Dasatinib; Disease Progression; DNA Repair; Epothilones; Gene Fusion; Humans; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Proto-Oncogene Proteins c-met; Pyrimidines; Receptors, Androgen; Taxoids; Thiazoles	2012

Trials

1 trial(s) available for thiazoles and epothilone a

Article	Year
Phase I trial of dasatinib and ixabepilone in patients with solid tumors. Investigational new drugs, 2013, Volume: 31, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Epothilones; Female; Humans; Male; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Tubulin Modulators	2013

Other Studies

85 other study(ies) available for thiazoles and epothilone a

Article	Year
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer research, 1995, Jun-01, Volume: 55, Issue:11 Topics: Animals; Binding, Competitive; Calcium; Cattle; Cells, Cultured; Cold Temperature; Colorimetry; Drug Resistance, Multiple; Epothilones; Epoxy Compounds; Filtration; Microtubule Proteins; Microtubules; Paclitaxel; Thiazoles	1995
Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. The Journal of antibiotics, 1996, Volume: 49, Issue:6 Topics: Animals; Antifungal Agents; Epothilones; Epoxy Compounds; Fermentation; Humans; Mice; Microbial Sensitivity Tests; Molecular Structure; Myxococcales; Thiazoles; Tumor Cells, Cultured	1996
Tumor-killer made; how does it work? Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295 Topics: Alkanes; Antineoplastic Agents; Carbamates; Computer Simulation; Epothilones; Epoxy Compounds; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured	1996
Myxobacterial bounty. Nature, 1997, Jan-09, Volume: 385, Issue:6612 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Myxococcales; Paclitaxel; Thiazoles	1997
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). The Journal of biological chemistry, 1997, Jan-24, Volume: 272, Issue:4 Topics: Drug Resistance, Multiple; Epothilones; Epoxy Compounds; Guanosine Triphosphate; Humans; Kidney; Kinetics; Microtubule-Associated Proteins; Mitotic Index; Paclitaxel; Polymers; Thiazoles; Tubulin; Tumor Cells, Cultured	1997
Synthetic chemistry. Cancer drugs better than taxol? Nature, 1997, May-15, Volume: 387, Issue:6630 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Drug Design; Epothilones; Epoxy Compounds; Paclitaxel; Structure-Activity Relationship; Thiazoles; Tubulin	1997
Synthesis of epothilones A and B in solid and solution phase. Nature, 1997, May-15, Volume: 387, Issue:6630 Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Humans; Solutions; Thiazoles; Tubulin; Tumor Cells, Cultured	1997
Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. The Journal of biological chemistry, 1997, Jul-04, Volume: 272, Issue:27 Topics: Antineoplastic Agents, Phytogenic; Binding Sites; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Female; Humans; Models, Molecular; Nucleic Acid Hybridization; Ovarian Neoplasms; Paclitaxel; Phenotype; Polymerase Chain Reaction; Polymers; Thiazoles; Tubulin; Tumor Cells, Cultured	1997
Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity. Cancer research, 1997, Aug-15, Volume: 57, Issue:16 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Adhesion; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Interferon-gamma; Macrophage Activation; Macrophages; Mice; Microtubules; Nitric Oxide; Paclitaxel; Rotenone; Thiazoles	1997
Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones. Proceedings of the National Academy of Sciences of the United States of America, 1998, Feb-17, Volume: 95, Issue:4 Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Cell Cycle; DNA Fragmentation; Drug Synergism; Enzyme Inhibitors; Epothilones; Farnesyltranstransferase; Humans; Methionine; Mitosis; Paclitaxel; Thiazoles; Tumor Cells, Cultured	1998
Plasmodium falciparum: characterization of organelle migration during merozoite morphogenesis in asexual malaria infections. Experimental parasitology, 1998, Volume: 88, Issue:3 Topics: Animals; Antimalarials; Antineoplastic Agents; Epothilones; Epoxy Compounds; Erythrocytes; Humans; Microscopy, Electron; Microtubules; Organelles; Paclitaxel; Plasmodium falciparum; Thiazoles	1998
Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones. Chemistry & biology, 1998, Volume: 5, Issue:7 Topics: Animals; Antineoplastic Agents; Epothilones; Lactones; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured	1998
Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. Proceedings of the National Academy of Sciences of the United States of America, 1998, Aug-04, Volume: 95, Issue:16 Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; Epothilones; Humans; Lactones; Mice; Mice, Nude; Microtubules; Neoplasm Transplantation; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured	1998
The antibody catalysis route to the total synthesis of epothilones. Proceedings of the National Academy of Sciences of the United States of America, 1998, Dec-08, Volume: 95, Issue:25 Topics: Antibodies, Catalytic; Epothilones; Epoxy Compounds; Fructose-Bisphosphate Aldolase; Thiazoles	1998
Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells. FEBS letters, 1998, Nov-20, Volume: 439, Issue:3 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caveolin 1; Caveolins; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Organelles; Paclitaxel; Thiazoles; Tumor Cells, Cultured; Up-Regulation	1998
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. Proceedings of the National Academy of Sciences of the United States of America, 1998, Dec-22, Volume: 95, Issue:26 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Epothilones; Female; Humans; Lactones; Leukemia P388; Leukemia-Lymphoma, Adult T-Cell; Mice; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Structure-Activity Relationship; Thiazoles; Transplantation, Heterologous; Tumor Cells, Cultured	1998
Oxidative and reductive transformations of epothilone A. Bioorganic & medicinal chemistry letters, 1998, Nov-03, Volume: 8, Issue:21 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Fermentation; Oxidation-Reduction; Thiazoles	1998
Derivatization of the C12-C13 functional groups of epothilones A, B and C. Bioorganic & medicinal chemistry letters, 1998, Nov-03, Volume: 8, Issue:21 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Structure-Activity Relationship; Thiazoles	1998
Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones. Biotechnology and bioengineering, 1998, Jun-05, Volume: 58, Issue:5 Topics: Antineoplastic Agents; Biotransformation; Cloning, Molecular; Epothilones; Epoxy Compounds; Escherichia coli; Esterases; Plasmids; Pseudomonas fluorescens; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Thiazoles	1998
A common pharmacophore for cytotoxic natural products that stabilize microtubules. Proceedings of the National Academy of Sciences of the United States of America, 1999, Apr-13, Volume: 96, Issue:8 Topics: Alkaloids; Alkanes; Antineoplastic Agents, Phytogenic; Carbamates; Computer Graphics; Diterpenes; Epothilones; Epoxy Compounds; Lactones; Magnetic Resonance Spectroscopy; Microtubules; Models, Molecular; Molecular Conformation; Molecular Structure; Paclitaxel; Pyrones; Thiazoles	1999
The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry, 1999, Apr-27, Volume: 38, Issue:17 Topics: Alkaloids; Animals; Antineoplastic Agents; Binding, Competitive; Cnidaria; Diterpenes; Docetaxel; Epothilones; Epoxy Compounds; Growth Inhibitors; Guanosine Triphosphate; Humans; Microtubule-Associated Proteins; Paclitaxel; Polymers; Protein Binding; Protein Processing, Post-Translational; Taxoids; Thiazoles; Tubulin; Tumor Cells, Cultured	1999
Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy. Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:5 Topics: Chromatography, Thin Layer; Epothilones; Epoxy Compounds; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Thiazoles	1999
Cloning and heterologous expression of the epothilone gene cluster. Science (New York, N.Y.), 2000, Jan-28, Volume: 287, Issue:5453 Topics: Bacterial Proteins; Cloning, Molecular; Cosmids; Cytochrome P-450 Enzyme System; Epothilones; Epoxy Compounds; Fermentation; Genes, Bacterial; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Myxococcales; Operon; Oxidoreductases; Recombinant Proteins; Streptomyces; Thiazoles; Transformation, Genetic	2000
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. Chemistry & biology, 2000, Volume: 7, Issue:2 Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacterial Proteins; Base Sequence; Cloning, Molecular; Epothilones; Epoxy Compounds; Gene Library; Genes, Bacterial; Macrolides; Microtubules; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Myxococcales; Open Reading Frames; Peptide Synthases; Protein Biosynthesis; Thiazoles	2000
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-14, Volume: 97, Issue:6 Topics: Alkaloids; Antineoplastic Agents; Bridged-Ring Compounds; Diterpenes; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Molecular; Mutation; Paclitaxel; Protein Conformation; Structure-Activity Relationship; Taxoids; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster. Gene, 2000, Apr-18, Volume: 247, Issue:1-2 Topics: Antineoplastic Agents; Bacillus subtilis; Computer Simulation; DNA Probes; DNA, Bacterial; Epothilones; Epoxy Compounds; Genome, Bacterial; Multienzyme Complexes; Multigene Family; Myxococcales; Nucleic Acid Hybridization; Peptide Synthases; Sequence Analysis, DNA; Thiazoles	2000
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:5 Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Carbamates; Cell Count; Cell Division; Cell Line; Cytoskeleton; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epothilones; Epoxy Compounds; Flow Cytometry; Humans; Lactones; Lung Neoplasms; Microtubules; Mitosis; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured	2000
A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone. Organic letters, 1999, Jul-15, Volume: 1, Issue:1 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Magnetic Resonance Spectroscopy; Microtubules; Models, Molecular; Monte Carlo Method; Paclitaxel; Protein Binding; Receptors, Drug; Structure-Activity Relationship; Thiazoles; Tubulin	1999
Improved synthesis of epothilone B employing alkylation of an alkyne for assembly of subunits. Organic letters, 1999, Nov-04, Volume: 1, Issue:9 Topics: Alkylation; Alkynes; Antineoplastic Agents; Epothilones; Epoxy Compounds; Thiazoles	1999
Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. Gene, 2000, May-16, Volume: 249, Issue:1-2 Topics: Amino Acid Sequence; Bacterial Proteins; Cytochrome P-450 Enzyme System; DNA; Epothilones; Epoxy Compounds; Genes, Bacterial; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Myxococcales; Oxidoreductases; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thiazoles	2000
Sets of aldolase antibodies with antipodal reactivities. Formal synthesis of epothilone E by large-scale antibody-catalyzed resolution of thiazole aldol. Organic letters, 1999, Nov-18, Volume: 1, Issue:10 Topics: Antibodies, Catalytic; Antibodies, Monoclonal; Epothilones; Epoxy Compounds; Fructose-Bisphosphate Aldolase; Immunization; Thiazoles	1999
Synthesis, structure proof, and biological activity of epothilone cyclopropanes. Organic letters, 2000, Jun-01, Volume: 2, Issue:11 Topics: Antineoplastic Agents; Cell Survival; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Lactones; Models, Molecular; Molecular Structure; Thermodynamics; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B. Organic letters, 2000, Jun-01, Volume: 2, Issue:11 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Lactones; Thiazoles	2000
On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. Organic letters, 2000, Jun-01, Volume: 2, Issue:11 Topics: Antineoplastic Agents; Aza Compounds; Cell Survival; Epothilones; Epoxy Compounds; Humans; Lactones; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues. Chemistry (Weinheim an der Bergstrasse, Germany), 2000, Aug-04, Volume: 6, Issue:15 Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Indicators and Reagents; Molecular Conformation; Molecular Structure; Structure-Activity Relationship; Thiazoles	2000
Total synthesis of epothilone A. Organic letters, 2000, Aug-24, Volume: 2, Issue:17 Topics: Aldehydes; Antineoplastic Agents; Epothilones; Epoxy Compounds; Indicators and Reagents; Thiazoles	2000
Chemical synthesis and biological properties of pyridine epothilones. Chemistry & biology, 2000, Volume: 7, Issue:8 Topics: Antineoplastic Agents; Cell Division; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Macrolides; Models, Molecular; Molecular Structure; Pyridines; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
Total synthesis and antitumor activity of 12,13-desoxyepothilone F: an unexpected solvolysis problem at C15, mediated by remote substitution at C21. The Journal of organic chemistry, 2000, Oct-06, Volume: 65, Issue:20 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Epothilones; Humans; Lactones; Mice; Mice, Nude; Paclitaxel; Thiazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2000
Total syntheses of epothilones B and D. The Journal of organic chemistry, 2000, Nov-03, Volume: 65, Issue:22 Topics: Antineoplastic Agents, Phytogenic; Epothilones; Epoxy Compounds; Indicators and Reagents; Thiazoles	2000
Synthesis and biological evaluation of highly potent analogues of epothilones B and D. Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24 Topics: Antineoplastic Agents; Cell Division; Drug Resistance; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Paclitaxel; Stereoisomerism; Thiazoles; Tumor Cells, Cultured	2000
In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2001, Volume: 15, Issue:1 Topics: Animals; Antineoplastic Agents; Biotransformation; Chromatography, High Pressure Liquid; Epothilones; Epoxy Compounds; Female; Humans; Liver; Mass Spectrometry; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Thiazoles	2001
Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase. The Journal of antibiotics, 2001, Volume: 54, Issue:2 Topics: Binding Sites; Epothilones; Epoxy Compounds; Multienzyme Complexes; Mutation; Oxygenases; Proteobacteria; Thiazoles	2001
Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F. Chemistry (Weinheim an der Bergstrasse, Germany), 2001, Apr-17, Volume: 7, Issue:8 Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antibodies, Catalytic; Antineoplastic Agents; Epothilones; Epoxy Compounds; Fructose-Bisphosphate Aldolase; Haptens; Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Myxococcales; Stereoisomerism; Thiazoles	2001
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:5 Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Survival; Colonic Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Female; Humans; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Sarcoma; Thiazoles; Tubulin; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays	2001
Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D. Journal of the American Chemical Society, 2001, Jun-13, Volume: 123, Issue:23 Topics: Animals; Antineoplastic Agents; Cell Division; Epothilones; Epoxy Compounds; Humans; Macrolides; Swine; Thiazoles; Tubulin; Tumor Cells, Cultured	2001
On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones. The Journal of organic chemistry, 2001, Jun-15, Volume: 66, Issue:12 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Humans; K562 Cells; Mice; Mice, Nude; Neoplasm Transplantation; Spectrum Analysis; Thiazoles	2001
Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells. Leukemia, 2001, Volume: 15, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Boronic Acids; Bortezomib; Cell Cycle; Cell Survival; Cyclosporins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Flavonoids; Hematopoietic Stem Cells; HL-60 Cells; Humans; Jurkat Cells; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Oligopeptides; Paclitaxel; Piperidines; Poly(ADP-ribose) Polymerases; Pyrazines; Substrate Specificity; Thiazoles	2001
Microtubule structure at improved resolution. Biochemistry, 2001, Jul-10, Volume: 40, Issue:27 Topics: Actin Cytoskeleton; Alkaloids; Amino Acid Sequence; Animals; Dimerization; Diterpenes; Docetaxel; Epothilones; Epoxy Compounds; Excipients; Guanosine Triphosphate; Microtubules; Molecular Sequence Data; Paclitaxel; Protein Conformation; Surface Properties; Swine; Taxoids; Thiazoles; Tubulin	2001
The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice. Proceedings of the National Academy of Sciences of the United States of America, 2001, Jul-03, Volume: 98, Issue:14 Topics: Animals; Antineoplastic Agents; Epothilones; Humans; Lactones; Mice; Mice, Nude; Microtubules; Neoplasm Transplantation; Neoplasms, Experimental; Thiazoles; Transplantation, Heterologous	2001
Total synthesis of epothilones B and D. Organic letters, 2001, Jul-12, Volume: 3, Issue:14 Topics: Alkenes; Biological Factors; Catalysis; Epothilones; Epoxy Compounds; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Thiazoles	2001
Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F. Journal of the American Chemical Society, 2001, Jun-06, Volume: 123, Issue:22 Topics: Antineoplastic Agents; Epothilones; Lactones; Stereoisomerism; Thiazoles	2001
Stereoselective syntheses of epothilones A and B via directed nitrile oxide cycloaddition. Journal of the American Chemical Society, 2001, Apr-18, Volume: 123, Issue:15 Topics: Antineoplastic Agents; Cyclization; Epothilones; Epoxy Compounds; Molecular Conformation; Nitric Oxide; Thiazoles	2001
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. Journal of natural products, 2001, Volume: 64, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Line; Chromatography, High Pressure Liquid; Epothilones; Epoxy Compounds; Fibroblasts; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Myxococcales; Structure-Activity Relationship; Thiazoles	2001
Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:8 Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Carbamates; Carotenoids; Diterpenes; Epothilones; Epoxy Compounds; Haplorhini; Humans; Lactones; Ligands; Lutein; Models, Molecular; Molecular Sequence Data; Paclitaxel; Pyrones; Retina; Thiazoles; Tubulin	2001
Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies. The Journal of organic chemistry, 2001, Sep-21, Volume: 66, Issue:19 Topics: Aldehydes; Antineoplastic Agents; Cyclization; Epothilones; Epoxy Compounds; Molecular Conformation; Nitric Oxide; Thiazoles	2001
Subcellular distribution of epothilones in human tumor cells. Proceedings of the National Academy of Sciences of the United States of America, 2001, Sep-25, Volume: 98, Issue:20 Topics: Antineoplastic Agents, Phytogenic; Cell Division; Cell Line; Epothilones; Epoxy Compounds; Humans; Kinetics; Macrolides; Paclitaxel; Thiazoles; Tumor Cells, Cultured; Verapamil	2001
Clinical trials referral resource. Current clinical trials of epothilone B analog (BMS-247550). Oncology (Williston Park, N.Y.), 2001, Volume: 15, Issue:9 Topics: Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Evaluation; Epothilones; Epoxy Compounds; Female; Humans; Male; Mice; Neoplasms; Thiazoles	2001
Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells. Cancer research, 2002, Jan-15, Volume: 62, Issue:2 Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Epothilones; Epoxy Compounds; G2 Phase; Humans; Mitochondria; Mitosis; Protein Conformation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Tumor Cells, Cultured	2002
Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones. Chembiochem : a European journal of chemical biology, 2001, Jan-08, Volume: 2, Issue:1 Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epothilones; Humans; Indicators and Reagents; Lactones; Microscopy, Electron; Models, Molecular; Stereoisomerism; Thiazoles; Tubulin; Tumor Cells, Cultured	2001
Synthesis of epothilone analogues by antibody-catalyzed resolution of thiazole aldol synthons on a multigram scale. Biological consequences of C-13 alkylation of epothilones. Chembiochem : a European journal of chemical biology, 2001, Sep-03, Volume: 2, Issue:9 Topics: Aldehyde-Lyases; Alkylation; Animals; Antibodies; Antineoplastic Agents; Catalysis; Epothilones; Humans; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Molecular Conformation; Stereoisomerism; Swine; Thiazoles; Tubulin; Tumor Cells, Cultured	2001
Synthesis, conformational analysis, and bioassay of 9,10-didehydroepothilone D. Organic letters, 2002, Mar-21, Volume: 4, Issue:6 Topics: Antineoplastic Agents; Biopolymers; Cell Division; Epothilones; Molecular Conformation; Thiazoles; Tubulin	2002
Optimizing the heterologous production of epothilone D in Myxococcus xanthus. Biotechnology and bioengineering, 2002, May-05, Volume: 78, Issue:3 Topics: Drug Stability; Epothilones; Epoxy Compounds; Fermentation; Myxococcus xanthus; Oleic Acids; Resins, Synthetic; Substrate Specificity; Thiazoles; Trace Elements	2002
Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis. Blood, 2002, May-01, Volume: 99, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Drug Synergism; Epothilones; Epoxy Compounds; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Macrolides; Membrane Glycoproteins; Mitochondrial Proteins; Peptide Fragments; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha	2002
Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces. Biochemistry, 2002, Apr-30, Volume: 41, Issue:17 Topics: Acrylates; Acyl Carrier Protein; Acyltransferases; Alcohol Oxidoreductases; Antineoplastic Agents; Bacterial Proteins; Epothilones; Escherichia coli; Hydro-Lyases; Macrolides; Multienzyme Complexes; Peptide Synthases; Protein Structure, Tertiary; Proteins; Thiazoles	2002
Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures. Journal of natural products, 2002, Volume: 65, Issue:4 Topics: Carbon; Chemistry, Organic; Chromatography, High Pressure Liquid; Crystallization; Epothilones; Epoxy Compounds; Mass Spectrometry; Molecular Conformation; Multienzyme Complexes; Myxococcus; Thiazoles	2002
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. Journal of natural products, 2002, Volume: 65, Issue:7 Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Breast Neoplasms; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Female; Genetic Engineering; Glioma; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia, Promyelocytic, Acute; Leukemia, T-Cell; Lung Neoplasms; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Myxococcus xanthus; Nuclear Magnetic Resonance, Biomolecular; Thiazoles; Tubulin; Tumor Cells, Cultured	2002
Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490. Journal of the American Chemical Society, 2002, Aug-21, Volume: 124, Issue:33 Topics: Animals; Antineoplastic Agents; Epothilones; Humans; Macrolides; Mice; Models, Molecular; Structure-Activity Relationship; Thiazoles; Xenograft Model Antitumor Assays	2002
Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis. Chemical communications (Cambridge, England), 2002, Dec-07, Issue:23 Topics: Cyclization; Epothilones; Indicators and Reagents; Macrolides; Thiazoles	2002
Generation of novel epothilone analogs with cytotoxic activity by biotransformation. The Journal of antibiotics, 2003, Volume: 56, Issue:1 Topics: Actinomycetales; Animals; Antineoplastic Agents; Biotransformation; Cell Division; Epothilones; Humans; Macrolides; Molecular Conformation; Thiazoles; Tumor Cells, Cultured	2003
Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation. Biochemistry, 2003, Aug-19, Volume: 42, Issue:32 Topics: Bleomycin; Epothilones; Escherichia coli; Escherichia coli Proteins; Esters; Flavin Mononucleotide; Kinetics; Oxidation-Reduction; Oxidoreductases; Peptide Chain Elongation, Translational; Protein Structure, Tertiary; Recombinant Proteins; Stereoisomerism; Sulfhydryl Compounds; Thiazoles	2003
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B. Molecular cancer therapeutics, 2003, Volume: 2, Issue:10 Topics: Annexin A5; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chromatin; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Deoxycytidine; Detergents; Docetaxel; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epothilones; Flow Cytometry; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Multienzyme Complexes; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Sepharose; Taxoids; Tetrazolium Salts; Thiazoles; Time Factors; Trastuzumab	2003
Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer. Gynecologic oncology, 2004, Volume: 93, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Epothilones; Female; Flow Cytometry; Fluorescent Antibody Technique; G2 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Metallothionein; Mitosis; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha; Up-Regulation	2004
What makes epothilones stick? Chemistry & biology, 2004, Volume: 11, Issue:2 Topics: Epothilones; Molecular Conformation; Pyridines; Structure-Activity Relationship; Thiazoles	2004
Heterologous production of epothilone C and D in Escherichia coli. Biochemistry, 2006, Jan-31, Volume: 45, Issue:4 Topics: Catalysis; Cysteamine; Epothilones; Escherichia coli; Methacrylates; Peptide Chain Elongation, Translational; Peptide Synthases; Polyketide Synthases; Thiazoles	2006
A reassignment of (-)-mycothiazole and the isolation of a related diol. Journal of natural products, 2006, Volume: 69, Issue:1 Topics: Alcohols; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Drug Screening Assays, Antitumor; Epothilones; Molecular Structure; Polyketide Synthases; Porifera; Stereoisomerism; Thiazoles; Thiazolidines; Vanuatu	2006
C-15 thiazol-4-yl analogues of (E)-9,10-didehydroepothilone D: synthesis and cytotoxicity. Organic letters, 2006, Jul-06, Volume: 8, Issue:14 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epothilones; Humans; Inhibitory Concentration 50; Molecular Structure; Thiazoles	2006
Semisynthetic derivatives of epothilones. Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles, 2009, Volume: 90 Topics: Epothilones; Epoxy Compounds; Esters; Thiazoles	2009
Design, synthesis, and biological evaluation of artificial macrosphelides in the search for new apoptosis-inducing agents. Chemistry (Weinheim an der Bergstrasse, Germany), 2009, Jun-02, Volume: 15, Issue:23 Topics: Antineoplastic Agents; Apoptosis; Cyclization; Drug Design; Drug Screening Assays, Antitumor; Epothilones; Humans; Molecular Structure; Structure-Activity Relationship; Thiazoles	2009
Extended and clustered conformers of epothilone A. The journal of physical chemistry. B, 2011, Apr-07, Volume: 115, Issue:13 Topics: Antineoplastic Agents; Epothilones; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Conformation; Thermodynamics; Thiazoles	2011
Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines--lessons for design of combination targeted therapy. Cancer letters, 2012, Jul-01, Volume: 320, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; Dasatinib; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epothilones; Female; Humans; Morpholines; Niacinamide; Nitriles; Paclitaxel; Phenylurea Compounds; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Sorafenib; Tamoxifen; Thiazoles	2012
In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma. Anti-cancer drugs, 2013, Volume: 24, Issue:3 Topics: Alanine; alpha-Fetoproteins; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma, Hepatocellular; Cetuximab; Dasatinib; Doxorubicin; Drug Screening Assays, Antitumor; Epothilones; Gefitinib; Humans; Indoles; Inhibitory Concentration 50; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridones; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Triazines	2013
Divergent mechanistic routes for the formation of gem-dimethyl groups in the biosynthesis of complex polyketides. Angewandte Chemie (International ed. in English), 2015, Feb-16, Volume: 54, Issue:8 Topics: Acyl Carrier Protein; Epothilones; Mass Spectrometry; Methylation; Phenols; Polyketide Synthases; Polyketides; Thiazoles	2015
Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. Neuropharmacology, 2016, Volume: 105 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Dendritic Spines; Diamines; Epothilones; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nocodazole; PC12 Cells; Rats; Thiazoles; Tubulin Modulators	2016
Structural elements of an NRPS cyclization domain and its intermodule docking domain. Proceedings of the National Academy of Sciences of the United States of America, 2016, 11-01, Volume: 113, Issue:44 Topics: Amino Acid Sequence; Bacterial Proteins; Biosynthetic Pathways; Catalytic Domain; Crystallography, X-Ray; Cyclization; Epothilones; Models, Molecular; Myxococcales; Peptide Synthases; Polyketide Synthases; Protein Binding; Protein Domains; Sequence Homology, Amino Acid; Thiazoles	2016
Photoswitchable Epothilone-Based Microtubule Stabilisers Allow GFP-Imaging-Compatible, Optical Control over the Microtubule Cytoskeleton. Angewandte Chemie (International ed. in English), 2022, 03-01, Volume: 61, Issue:10 Topics: Cytoskeleton; Epothilones; Green Fluorescent Proteins; Microtubules; Models, Molecular; Molecular Structure; Photochemical Processes; Styrenes; Thiazoles	2022