Compounds > thiazoles
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thiazoles and desoxyepothilone b

thiazoles has been researched along with desoxyepothilone b in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.00)18.2507
2000's17 (85.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balog, A; Bertino, JR; Chou, TC; Danishefsky, SJ; Meng, D; Savin, K; Su, DS; Zhang, XG1
Balog, A; Bertino, JR; Chou, TC; Danishefsky, SJ; Harris, CR; Kuduk, SD; Savin, KA; Zhang, XG1
Altmann, KH; O'Reilly, T; Wartmann, M1
Chappell, MD; Danishefsky, SJ; Lee, CB; Stachel, SJ1
Chappell, MD; Chou, TC; Danishefsky, SJ; He, L; Horwitz, SB; Lee, CB; Stachel, SJ1
Mantoulidis, A; Mulzer, J; Ohler, E1
Altmann, KH; Bold, G; Caravatti, G; Flörsheimer, A; Guagnano, V; Wartmann, M1
Lerner, RA; Miller, GP; Sinha, SC; Sun, J; Wartmann, M1
Carter, RG; Sundermann, KF; Wartmann, M; White, JD1
Chou, TC; Danishefsky, SJ; Guan, Y; Lee, C; O'Connor, OA; Stachel, SJ; Tong, WP; Zhang, ZG1
Chen, Y; Taylor, RE1
Gerth, K; Hardt, IH; Höfle, G; Reichenbach, H; Sasse, F; Steinmetz, H1
Buchmann, B; Bunte, T; Hoffmann, J; Klar, U; Lichtner, RB; Rotgeri, A; Schwede, W; Skuballa, W1
Hertweck, C1
Frykman, S; Lau, J; Licari, P; Ou, S; Regentin, R; Tsuruta, H1
Arslanian, RL; Lau, J; Licari, PJ; McIntire, JR; Parker, CD; Starks, C; Wang, PK1
Arslanian, RL; Blough, S; Carney, JR; Katz, L; Ma, W; Qiu, RG; Tang, L1
Katz, L; Li, Y; Qiu, RG; Tang, L1
Carney, JR; Kennedy, J; Liu, Y; Mutka, SC1
Bakota, L; Ballatore, C; Brandt, R; Ghori, A; Golovyashkina, N; Niewidok, B; Penazzi, L; Selle, K; Smith, AB; Tackenberg, C1

Reviews

2 review(s) available for thiazoles and desoxyepothilone b

ArticleYear
Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.
    Biochimica et biophysica acta, 2000, May-17, Volume: 1470, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line; Cell Membrane Permeability; Drug Resistance, Multiple; Drug Tolerance; Epothilones; Epoxy Compounds; Humans; Lactones; Microtubules; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured

2000
The multiplasmid approach: a new perspective for combinatorial biosynthesis.
    Chembiochem : a European journal of chemical biology, 2000, Aug-18, Volume: 1, Issue:2

    Topics: Acyl Coenzyme A; Antineoplastic Agents; Bacterial Proteins; Carrier Proteins; Combinatorial Chemistry Techniques; Epothilones; Epoxy Compounds; Genes, Bacterial; Lactones; Macrolides; Molecular Structure; Multienzyme Complexes; Open Reading Frames; Plasmids; Thiazoles

2000

Other Studies

18 other study(ies) available for thiazoles and desoxyepothilone b

ArticleYear
Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Aug-04, Volume: 95, Issue:16

    Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; Epothilones; Humans; Lactones; Mice; Mice, Nude; Microtubules; Neoplasm Transplantation; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured

1998
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Dec-22, Volume: 95, Issue:26

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Epothilones; Female; Humans; Lactones; Leukemia P388; Leukemia-Lymphoma, Adult T-Cell; Mice; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Structure-Activity Relationship; Thiazoles; Transplantation, Heterologous; Tumor Cells, Cultured

1998
En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B.
    Organic letters, 2000, Jun-01, Volume: 2, Issue:11

    Topics: Antineoplastic Agents; Epothilones; Epoxy Compounds; Lactones; Thiazoles

2000
On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments.
    Organic letters, 2000, Jun-01, Volume: 2, Issue:11

    Topics: Antineoplastic Agents; Aza Compounds; Cell Survival; Epothilones; Epoxy Compounds; Humans; Lactones; Thiazoles; Tubulin; Tumor Cells, Cultured

2000
Total syntheses of epothilones B and D.
    The Journal of organic chemistry, 2000, Nov-03, Volume: 65, Issue:22

    Topics: Antineoplastic Agents, Phytogenic; Epothilones; Epoxy Compounds; Indicators and Reagents; Thiazoles

2000
Synthesis and biological evaluation of highly potent analogues of epothilones B and D.
    Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24

    Topics: Antineoplastic Agents; Cell Division; Drug Resistance; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Paclitaxel; Stereoisomerism; Thiazoles; Tumor Cells, Cultured

2000
Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2001, Apr-17, Volume: 7, Issue:8

    Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antibodies, Catalytic; Antineoplastic Agents; Epothilones; Epoxy Compounds; Fructose-Bisphosphate Aldolase; Haptens; Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Myxococcales; Stereoisomerism; Thiazoles

2001
Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D.
    Journal of the American Chemical Society, 2001, Jun-13, Volume: 123, Issue:23

    Topics: Animals; Antineoplastic Agents; Cell Division; Epothilones; Epoxy Compounds; Humans; Macrolides; Swine; Thiazoles; Tubulin; Tumor Cells, Cultured

2001
The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Jul-03, Volume: 98, Issue:14

    Topics: Animals; Antineoplastic Agents; Epothilones; Humans; Lactones; Mice; Mice, Nude; Microtubules; Neoplasm Transplantation; Neoplasms, Experimental; Thiazoles; Transplantation, Heterologous

2001
Total synthesis of epothilones B and D.
    Organic letters, 2001, Jul-12, Volume: 3, Issue:14

    Topics: Alkenes; Biological Factors; Catalysis; Epothilones; Epoxy Compounds; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Thiazoles

2001
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.
    Journal of natural products, 2001, Volume: 64, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line; Chromatography, High Pressure Liquid; Epothilones; Epoxy Compounds; Fibroblasts; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Myxococcales; Structure-Activity Relationship; Thiazoles

2001
Subcellular distribution of epothilones in human tumor cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Sep-25, Volume: 98, Issue:20

    Topics: Antineoplastic Agents, Phytogenic; Cell Division; Cell Line; Epothilones; Epoxy Compounds; Humans; Kinetics; Macrolides; Paclitaxel; Thiazoles; Tumor Cells, Cultured; Verapamil

2001
Optimizing the heterologous production of epothilone D in Myxococcus xanthus.
    Biotechnology and bioengineering, 2002, May-05, Volume: 78, Issue:3

    Topics: Drug Stability; Epothilones; Epoxy Compounds; Fermentation; Myxococcus xanthus; Oleic Acids; Resins, Synthetic; Substrate Specificity; Thiazoles; Trace Elements

2002
Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures.
    Journal of natural products, 2002, Volume: 65, Issue:4

    Topics: Carbon; Chemistry, Organic; Chromatography, High Pressure Liquid; Crystallization; Epothilones; Epoxy Compounds; Mass Spectrometry; Molecular Conformation; Multienzyme Complexes; Myxococcus; Thiazoles

2002
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus.
    Journal of natural products, 2002, Volume: 65, Issue:7

    Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Breast Neoplasms; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Female; Genetic Engineering; Glioma; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia, Promyelocytic, Acute; Leukemia, T-Cell; Lung Neoplasms; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Myxococcus xanthus; Nuclear Magnetic Resonance, Biomolecular; Thiazoles; Tubulin; Tumor Cells, Cultured

2002
Generation of novel epothilone analogs with cytotoxic activity by biotransformation.
    The Journal of antibiotics, 2003, Volume: 56, Issue:1

    Topics: Actinomycetales; Animals; Antineoplastic Agents; Biotransformation; Cell Division; Epothilones; Humans; Macrolides; Molecular Conformation; Thiazoles; Tumor Cells, Cultured

2003
Heterologous production of epothilone C and D in Escherichia coli.
    Biochemistry, 2006, Jan-31, Volume: 45, Issue:4

    Topics: Catalysis; Cysteamine; Epothilones; Escherichia coli; Methacrylates; Peptide Chain Elongation, Translational; Peptide Synthases; Polyketide Synthases; Thiazoles

2006
Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D.
    Neuropharmacology, 2016, Volume: 105

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Dendritic Spines; Diamines; Epothilones; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nocodazole; PC12 Cells; Rats; Thiazoles; Tubulin Modulators

2016