Page last updated: 2024-08-21

thiazoles and desferrithiocin

thiazoles has been researched along with desferrithiocin in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (18.92)	18.7374
1990's	15 (40.54)	18.2507
2000's	9 (24.32)	29.6817
2010's	6 (16.22)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baker, E; Jacobs, A; Peter, H; Wong, A	1
Hancock, WW; Kupiec-Weglinski, JW; Tilney, NL; Whitley, D	1
Cook, EP; Fragonas, JC; Hunt, NH	1
Bergeron, RJ; Dionis, JB; Egli-Karmakka, M; Frei, J; Huxley-Tencer, A; Peter, HH; Wiegand, J	1
Bergeron, RJ; Evans, KM; Jenny, HB; Luchetta, G; Peter, H; Streiff, RR; Vinson, JR; Wiegand, J	1
Bierer, BE; Nathan, DG	1
Wolfe, LC	1
Chaudhri, G; Clark, IA	1
Finger, J; Hegsted, M; Nathan, DG; Nicolosi, RJ; Peter, H; Renaud, MM; Wolfe, LC	1
Baquet, A; Crichton, RR; Florence, A; Jin, Y; Schneider, YJ	1
Cochrane, CG; Hyslop, PA; Jackson, JH; Sauerheber, R; Schraufstatter, IU; Vosbeck, K; Weitzman, SA	1
Hiller, W; Maichle, C; Schechinger, T; Strähle, J; Weser, U	1
Beaudoin, RL; Gentilini, M; Guillouzo, A; Landau, I; Langlois, P; Mazier, D; Mellouk, S; Miltgen, F; Stahel, E	1
Crichton, RR; Longueville, A	1
Bergeron, RJ; Wiegand, J; Wollenweber, M	1
Algee, SE; Bergeron, RJ; Liu, CZ; McManis, JS; Wiegand, J; Xia, MX	1
DeSousa, M; Hancock, WW; Kupiec-Weglinski, JW; Tilney, NL; Whitley, WD	1
Bergeron, RJ; Creary, EA; Daniels, RD; King, W; Luchetta, G; Moerker, T; Peter, HH; Streiff, RR; Wiegand, J	1
Algee, SE; Bergeron, RJ; McManis, JS; Ratliff-Thompson, K; Wiegand, J; Wollenweber, M	1
Crichton, RR; Dexter, DT; Florence, A; Jenner, P; Ward, RJ	1
Bergeron, RJ; Brittenham, GM; Bussenius, J; McManis, JS; Wiegand, J	1
Bergeron, RJ; Weimar, WR; Wiegand, J	1
Baker, E; Chua, AC; Kicic, A	1
Bergeron, RJ; Huang, G; McManis, JS; Smith, RE; Weimar, WR; Wiegand, J	1
Bergeron, RJ; Huang, G; McManis, JS; Weimar, WR; Wiegand, J	1
Bergeron, RJ; Nguyen, JN; Sninsky, CA; Weimar, WR; Wiegand, J	1
Acklin, P; Alberti, D; Buehlmayer, P; Hauffe, S; Lattmann, R; Nick, H; Schupp, J	1
Bergeron, J; Bergeron, RJ; Brittenham, GM; Eiler-McManis, E; McManis, JS; Park, JH; Weimar, WR; Wiegand, J	1
Hider, RC; Zhou, T	1
Bergeron, RJ; Bharti, N; McManis, JS; Singh, S; Wiegand, J	2
Bergeron, RJ; Singh, S; Wiegand, J	1
Abboud, KA; Bergeron, RJ; Bharti, N; McManis, JS; Singh, S; Wiegand, J	1
Bergeron, RJ; Bharti, N; McManis, JS; Wiegand, J	2
Aydinok, Y; Berk, G; Cohen, AR; Giardina, PJ; Jeglinski, BI; Kuo, KH; Kwiatkowski, JL; Neufeld, EJ; Pietropaolo, K; Saliba, AN; Taher, AT; Viprakasit, V	1
Dev, A; Jayaprakash, V; Shyam, M; Sinha, BN	1

Reviews

4 review(s) available for thiazoles and desferrithiocin

Article	Year
Structure-activity relationships among desazadesferrithiocin analogues. Advances in experimental medicine and biology, 2002, Volume: 509 Topics: Animals; Dihydropyridines; Drug Design; Humans; Iron; Iron Chelating Agents; Iron Overload; Ligands; Siderophores; Structure-Activity Relationship; Thiazoles	2002
Development of tridentate iron chelators: from desferrithiocin to ICL670. Current medicinal chemistry, 2003, Volume: 10, Issue:12 Topics: Animals; Benzoates; Callithrix; Chemical Phenomena; Chemistry, Physical; Deferasirox; Dihydropyridines; Dogs; Humans; Iron; Iron Chelating Agents; Rats; Thiazoles; Triazoles	2003
Desferrithiocin: a search for clinically effective iron chelators. Journal of medicinal chemistry, 2014, Nov-26, Volume: 57, Issue:22 Topics: Animals; Chemistry, Pharmaceutical; Dihydropyridines; Drug Design; Electron Transport; Ferritins; Homeostasis; Humans; Iron; Iron Chelating Agents; Iron Overload; Ligands; Oxidation-Reduction; Primates; Rats; Rats, Sprague-Dawley; Siderophores; Structure-Activity Relationship; Thiazoles; Transferrin	2014
Scaffold Based Search on the Desferithiocin Archetype. Mini reviews in medicinal chemistry, 2019, Volume: 19, Issue:19 Topics: Benzene Derivatives; Dihydropyridines; Humans; Iron Chelating Agents; Iron Overload; Pyridines; Structure-Activity Relationship; Thiazoles	2019

Trials

1 trial(s) available for thiazoles and desferrithiocin

Article	Year
Safety and pharmacokinetics of the oral iron chelator SP-420 in β-thalassemia. American journal of hematology, 2017, Volume: 92, Issue:12 Topics: Adolescent; Adult; beta-Thalassemia; Blood Transfusion; Cyclohexanones; Dihydropyridines; Dose-Response Relationship, Drug; Humans; Iron Chelating Agents; Kidney Diseases; Middle Aged; Siderophores; Thiazoles; Young Adult	2017

Other Studies

32 other study(ies) available for thiazoles and desferrithiocin

Article	Year
Desferrithiocin is an effective iron chelator in vivo and in vitro but ferrithiocin is toxic. British journal of haematology, 1992, Volume: 81, Issue:3 Topics: Administration, Oral; Animals; Aspartate Aminotransferases; Cells, Cultured; Deferoxamine; Dihydropyridines; Dose-Response Relationship, Drug; Injections, Subcutaneous; Iodine Radioisotopes; Iron; Iron Chelating Agents; Iron Radioisotopes; Liver; Rats; Rats, Wistar; Thiazoles; Time Factors; Transferrin; Weight Gain	1992
Oral iron chelator desferrithiocin blocks allogeneic mononuclear cell activation and cytokine production in vivo and prolongs rat cardiac allograft survival. Transplantation proceedings, 1992, Volume: 24, Issue:1 Topics: Animals; Cytokines; Dihydropyridines; Graft Survival; Heart Transplantation; Iron Chelating Agents; Lymphocyte Activation; Macrophage Activation; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Receptors, Interleukin-2; T-Lymphocytes; Thiazoles; Transplantation, Homologous	1992
Interference with oxidative processes inhibits proliferation of human peripheral blood lymphocytes and murine B-lymphocytes. International journal of immunopharmacology, 1991, Volume: 13, Issue:7 Topics: Animals; B-Lymphocytes; Deferoxamine; Dihydropyridines; DNA; Ferricyanides; Humans; In Vitro Techniques; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Oxygen; T-Lymphocytes; Thiazoles	1991
Evaluation of desferrithiocin and its synthetic analogues as orally effective iron chelators. Journal of medicinal chemistry, 1991, Volume: 34, Issue:7 Topics: Administration, Oral; Animals; Bile; Chemical Phenomena; Chemistry; Dihydropyridines; Drug Evaluation, Preclinical; Iron; Iron Chelating Agents; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles	1991
A comparative evaluation of iron clearance models. Annals of the New York Academy of Sciences, 1990, Volume: 612 Topics: Animals; Bile; Chelating Agents; Deferoxamine; Dihydropyridines; Haplorhini; Hydrazines; Iron; Iron Chelating Agents; Male; Rats; Rats, Inbred Strains; Spectrophotometry, Atomic; Thiazoles	1990
The effect of desferrithiocin, an oral iron chelator, on T-cell function. Blood, 1990, Nov-15, Volume: 76, Issue:10 Topics: Antigens, Surface; Calcium; Cell Division; Cell Membrane; Cells, Cultured; Cytotoxicity, Immunologic; Deferoxamine; Dihydropyridines; Humans; Interleukin-2; Iron; Iron Chelating Agents; Killer Cells, Natural; Lymphocyte Activation; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Thiazoles	1990
Desferrithiocin. Seminars in hematology, 1990, Volume: 27, Issue:2 Topics: Animals; Dihydropyridines; Iron Chelating Agents; Thiazoles	1990
Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor. Journal of immunology (Baltimore, Md. : 1950), 1989, Aug-15, Volume: 143, Issue:4 Topics: Animals; Antioxidants; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Deferoxamine; Dihydropyridines; Free Radicals; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred CBA; Oxygen; Peritoneal Cavity; Thiazoles; Tumor Necrosis Factor-alpha	1989
A non-human primate model for the study of oral iron chelators. British journal of haematology, 1989, Volume: 72, Issue:3 Topics: Administration, Oral; Animals; Cebus; Deferoxamine; Dihydropyridines; Disease Models, Animal; Injections, Intramuscular; Iron; Iron Chelating Agents; Thiazoles	1989
Desferrithiocin and desferrioxamine B. Cellular pharmacology and storage iron mobilization. Biochemical pharmacology, 1989, Oct-01, Volume: 38, Issue:19 Topics: Animals; Cells, Cultured; Deferoxamine; Dihydropyridines; Iron; Liver; Male; Rats; Rats, Inbred Strains; Thiazoles; Tritium	1989
Role of oxidants in DNA damage. Hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke. The Journal of clinical investigation, 1987, Volume: 80, Issue:4 Topics: Asbestos; Bacteriophages; Benzoates; Benzoic Acid; Catalase; Dihydropyridines; Dimethyl Sulfoxide; DNA; Drug Synergism; Electron Spin Resonance Spectroscopy; Hydroxides; Hydroxyl Radical; Mannitol; Nucleic Acid Conformation; Phenanthrolines; Smoking; Superoxide Dismutase; Thiazoles	1987
A five-coordinate copper complex with superoxide dismutase mimetic activity from Streptomyces antibioticus. Biology of metals, 1988, Volume: 1, Issue:2 Topics: Circular Dichroism; Copper; Dihydropyridines; Electron Spin Resonance Spectroscopy; Iron Chelating Agents; Models, Molecular; Spectrophotometry; Streptomyces; Streptomyces antibioticus; Superoxide Dismutase; Thermodynamics; Thiazoles; X-Ray Diffraction	1988
Iron chelators: in vitro inhibitory effect on the liver stage of rodent and human malaria. The American journal of tropical medicine and hygiene, 1988, Volume: 39, Issue:3 Topics: Animals; Cells, Cultured; Deferoxamine; Dihydropyridines; Humans; Iron Chelating Agents; Liver; Malaria; Microscopy, Electron; Plasmodium falciparum; Plasmodium yoelii; Rats; Thiazoles	1988
An animal model of iron overload and its application to study hepatic ferritin iron mobilization by chelators. Biochemical pharmacology, 1986, Nov-01, Volume: 35, Issue:21 Topics: Administration, Oral; Animals; Body Weight; Chelating Agents; Deferoxamine; Dihydropyridines; Ferritins; Ferrous Compounds; Injections, Intraperitoneal; Liver; Male; Metallocenes; Organ Size; Organometallic Compounds; Pyridines; Rats; Rats, Inbred Strains; Thiazoles	1986
An investigation of desferrithiocin metabolism. Journal of medicinal chemistry, 1994, Sep-02, Volume: 37, Issue:18 Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Dihydropyridines; Female; Hydrolysis; Iron; Kinetics; Male; Mice; Rats; Rats, Sprague-Dawley; Siderophores; Thiazoles	1994
The desferrithiocin pharmacophore. Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10 Topics: Animals; Dihydropyridines; Drug Design; Iron; Iron Chelating Agents; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Thiazoles	1994
Iron chelation suppresses mononuclear cell activation, modifies lymphocyte migration patterns, and prolongs rat cardiac allograft survival in rats. Transplantation, 1993, Volume: 56, Issue:5 Topics: Animals; Cell Movement; Dihydropyridines; Graft Survival; Heart Transplantation; Iron; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Rats; Rats, Inbred BN; Rats, Inbred Lew; Siderophores; T-Lymphocyte Subsets; Thiazoles; Transplantation, Homologous; Tumor Necrosis Factor-alpha	1993
A comparative study of the iron-clearing properties of desferrithiocin analogues with desferrioxamine B in a Cebus monkey model. Blood, 1993, Apr-15, Volume: 81, Issue:8 Topics: Animals; Cebus; Deferoxamine; Dihydropyridines; Feces; Gastrointestinal Diseases; Iron; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Siderophores; Thiazoles	1993
Synthesis and biological evaluation of naphthyldesferrithiocin iron chelators. Journal of medicinal chemistry, 1996, Apr-12, Volume: 39, Issue:8 Topics: Animals; Cebus; Dihydropyridines; Iron; Iron Chelating Agents; Male; Rats; Rats, Sprague-Dawley; Thiazoles	1996
Effects of desferrithiocin and its derivatives on peripheral iron and striatal dopamine and 5-hydroxytryptamine metabolism in the ferrocene-loaded rat. Biochemical pharmacology, 1999, Jul-01, Volume: 58, Issue:1 Topics: Administration, Oral; Animals; Corpus Striatum; Dihydropyridines; Dopamine; Ferrous Compounds; In Vitro Techniques; Iron; Iron Chelating Agents; Iron Overload; Male; Metallocenes; Rats; Rats, Wistar; Serotonin; Thiazoles	1999
Evaluation of the desferrithiocin pharmacophore as a vector for hydroxamates. Journal of medicinal chemistry, 1999, Jul-29, Volume: 42, Issue:15 Topics: Administration, Oral; Animals; Cebus; Dihydropyridines; Drug Evaluation, Preclinical; Hydroxamic Acids; Injections, Subcutaneous; Iron Chelating Agents; Iron Overload; Ligands; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles	1999
Pharmacokinetics of orally administered desferrithiocin analogs in cebus apella primates. Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:12 Topics: Administration, Oral; Animals; Cebus; Dihydropyridines; Humans; Iron Chelating Agents; Serum Albumin; Thiazoles	1999
Desferrithiocin is a more potent antineoplastic agent than desferrioxamine. British journal of pharmacology, 2002, Volume: 135, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Deferoxamine; Dihydropyridines; Fibroblasts; Hepatocytes; Humans; Iron; Iron Chelating Agents; Male; Mice; Rats; Rats, Wistar; Thiazoles; Tumor Cells, Cultured	2002
Desferrithiocin analogue based hexacoordinate iron(III) chelators. Journal of medicinal chemistry, 2003, Jan-02, Volume: 46, Issue:1 Topics: Animals; Ascorbic Acid; Bile; Cebus; Dihydropyridines; Feces; Free Radical Scavengers; Iron; Iron Chelating Agents; Ligands; Oxidation-Reduction; Resorcinols; Structure-Activity Relationship; Thiazoles	2003
Prevention of acetic acid-induced colitis by desferrithiocin analogs in a rat model. Digestive diseases and sciences, 2003, Volume: 48, Issue:2 Topics: Acetic Acid; Animals; Colitis; Dihydropyridines; Disease Models, Animal; Drug Interactions; Intestinal Mucosa; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Thiazoles	2003
Partition-variant desferrithiocin analogues: organ targeting and increased iron clearance. Journal of medicinal chemistry, 2005, Feb-10, Volume: 48, Issue:3 Topics: Animals; Antioxidants; Ascorbic Acid; Catechols; Cebus; Dihydropyridines; Free Radical Scavengers; Humans; In Vitro Techniques; Iron; Iron Chelating Agents; Liver; Male; Myocardium; Oxidation-Reduction; Pancreas; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles; Tissue Distribution	2005
The design of orally active iron chelators. Annals of the New York Academy of Sciences, 2005, Volume: 1054 Topics: Administration, Oral; Benzoates; Clinical Trials as Topic; Deferasirox; Dihydropyridines; Drug Design; Drug Evaluation, Preclinical; Humans; Iron; Iron Chelating Agents; Ligands; Models, Molecular; Molecular Structure; Oxidation-Reduction; Pyridones; Thiazoles; Triazoles	2005
Desferrithiocin analogues and nephrotoxicity. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Administration, Oral; Animals; Cebus; Dihydropyridines; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Iron; Iron Chelating Agents; Iron Overload; Kidney Diseases; Ligands; Lipids; Male; Molecular Conformation; Rats; Rats, Sprague-Dawley; Stereoisomerism; Thiazoles; Water	2008
Desferrithiocin analogue uranium decorporation agents. International journal of radiation biology, 2009, Volume: 85, Issue:4 Topics: Animals; Bile Ducts; Chelating Agents; Dihydropyridines; Dose-Response Relationship, Drug; Femur; Kidney; Ligands; Liver; Lung; Pentetic Acid; Rats; Spleen; Thiazoles; Uranium	2009
The impact of polyether chain length on the iron clearing efficiency and physiochemical properties of desferrithiocin analogues. Journal of medicinal chemistry, 2010, Apr-08, Volume: 53, Issue:7 Topics: Animals; Bile Ducts; Cebus; Chemical Phenomena; Crystallography, X-Ray; Dihydropyridines; Drug Design; Ether; Ethers; Humans; Iron; Iron Chelating Agents; Iron Overload; Kidney; Ligands; Male; Octanols; Rats; Thiazoles; Water	2010
Desferrithiocin analogue iron chelators: iron clearing efficiency, tissue distribution, and renal toxicity. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2011, Volume: 24, Issue:2 Topics: Animals; Cebus; Cell Adhesion Molecules; Dihydropyridines; Feces; Iron; Iron Chelating Agents; Kidney; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Thiazoles	2011
Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles. Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16 Topics: Administration, Oral; Animals; Cebus; Coordination Complexes; Dihydropyridines; Ethers; Ferric Compounds; Hydroxylation; Iron Chelating Agents; Iron Overload; Kidney; Ligands; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Thiazoles	2012