Page last updated: 2024-08-21

thiazoles and dc 107

thiazoles has been researched along with dc 107 in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (3.85)	18.7374
1990's	5 (9.62)	18.2507
2000's	25 (48.08)	29.6817
2010's	16 (30.77)	24.3611
2020's	4 (7.69)	2.80

Authors

Authors	Studies
Hara, M; Nakano, H; Saitoh, Y	1
Asano, K; Hara, M; Katsumata, S; Kawamoto, I; Nakano, H; Takahashi, K; Takiguchi, T	1
Asano, K; Hara, M; Kawamoto, I; Morimoto, M; Nakano, H; Takahashi, I; Yoshida, M	1
Behroozi, SJ; Dannaldson, J; Gates, KS; Kim, W	1
Asai, A; Saito, H; Saitoh, Y	1
Ashizawa, T; Gomi, K; Kanda, Y; Okabe, M; Saito, H; Saitoh, Y	1
Ashizawa, T; Kakita, S; Kanda, Y; Kono, M; Okabe, M; Saitoh, Y; Takahashi, Y; Yoshida, M	1
Breydo, L; Gates, KS	2
Greer, A; Wu, S	1
Gates, KS	1
Greer, A; Reznik, R	1
Breydo, L; Dannaldson, J; Gates, KS; Mitra, K; Zang, H	1
Breydo, L; Gates, KS; Mitra, K; Zang, H	1
Barnes, CL; Breydo, L; Gates, KS	1
Cheng, YQ; Shen, B; Tang, GL	5
Ashizawa, T; Ikeda, S; Kanda, Y; Kawashima, K; Tamaoki, T	1
Chatterji, T; Chowdhury, G; Gates, KS; Keerthi, K; Kizil, M; Pospísil, T	1
Martinetti, G; Pagani, G; Pregnolato, M; Salvetti, R; Ubiali, D	1
Gates, KS; Zang, H	1
Dutta, S; Gates, KS; Nooner, T	1
Bassett, S; Sun, D; Urrabaz, R	1
Gates, KS; Shipova, E	1
Bacskay, I; Fehér, P; Fenyvesi, F; Herczegh, P; Majercsik, O; Pelyvas, IF; Szilagyi, A; Varadi, J; Vecsernyés, M	1
Gates, KS; Keerthi, K	1
Ashby, MT; Nagy, P	1
Gates, KS; Sivaramakrishnan, S	1
Huang, Y; Liu, T; Shen, B	1
Gates, K; Sun, D; Viswesh, V	1
Huang, SX; Huang, Y; Ju, J; Liu, T; Shen, B; Tang, G	1
Breydo, L; Dutta, S; Fekry, MI; Gates, KS; Szekely, J; Zang, H	1
Breydo, L; Gates, KS; Sivaramakrishnan, S; Sun, D	1
Gates, K; Hays, AM; Sun, D; Viswesh, V	1
Bulgakova, VG; Orlova, TI; Polin, AN	1
Gates, KS; Keerthi, K; Rajapakse, A; Sun, D	1
Bingman, CA; Lohman, JR; Phillips, GN; Shen, B	1
Basu, HS; Church, DR; Huang, SX; Huang, Y; Ingenhorst, G; Ju, J; Liu, T; Lohman, JR; Ma, M; Shen, B; Tang, GL; Wilding, G; Yang, D; Yun, BS	1
Liu, T; Lohman, JR; Ma, M; Shen, B	1
Chang, CY; Huang, Y; Pan, G; Shen, B; Tang, GL	1
Huang, Y; Pan, G; Shen, B; Tang, GL; Yang, D	1
Cheng, J; Duan, Y; Gansemans, Y; Guo, Z; Huang, Y; Jiang, Y; Ma, M; Pan, G; Shen, B; Suh, JW; Van Nieuwerburgh, F; Xu, Z; Yang, D; Zhao, LX; Zhou, H; Zhu, X	1
Cleveland, JL; Kwong, T; Lohman, JR; Ma, M; Pan, G; Rudolf, JD; Shen, B; Yang, C; Yang, D	1
Du, YL; Ryan, KS	1
Adhikari, A; Shen, B; Teijaro, CN	1
Burkart, MD; Corpuz, JC; Davis, TD; Jaremko, MJ	1
Becerril, A; Braña, AF; Martín, J; Méndez, C; Pérez-Victoria, I; Reyes, F; Salas, JA; Ye, S	1
Kalkreuter, E; Liu, YC; Meng, S; Pan, G; Shen, B; Steele, AD; Xu, Z; Yan, W	1
Becerril, A; Martín, JM; Méndez, C; Pérez-Victoria, I; Reyes, F; Salas, JA	1

Reviews

5 review(s) available for thiazoles and dc 107

Article	Year
Mechanisms of DNA damage by leinamycin. Chemical research in toxicology, 2000, Volume: 13, Issue:10 Topics: Animals; Antibiotics, Antineoplastic; DNA Damage; Humans; Lactams; Macrolides; Sulfhydryl Compounds; Thiazoles; Thiones	2000
[Biologically active nonribosomal peptides. II. Nonribosomal peptides of various biological action]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2011, Volume: 56, Issue:11-12 Topics: Anti-Infective Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Beauveria; Chromobacterium; Depsipeptides; Isoquinolines; Lactams; Macrolides; Peptides; Peptides, Cyclic; Ribosomal Proteins; Thiazoles; Thiones	2011
Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products. Natural product reports, 2019, 03-20, Volume: 36, Issue:3 Topics: Biological Products; Imidazoles; Lactams; Lipoproteins; Macrolides; Oligopeptides; Pactamycin; Pyridoxal Phosphate; Saxitoxin; Thiazoles; Thiones	2019
Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts. Journal of industrial microbiology & biotechnology, 2019, Volume: 46, Issue:3-4 Topics: Adamantane; Aminobenzoates; Aminoglycosides; Aminophenols; Anilides; Bacterial Proteins; Biological Products; Biosynthetic Pathways; Drug Discovery; Enediynes; Gene Expression Regulation, Bacterial; Genes, Bacterial; Lactams; Macrolides; Metabolic Engineering; Multigene Family; Piperidones; Polycyclic Compounds; Protein Conformation; Sequence Analysis, DNA; Streptomyces; Thiazoles; Thiones	2019
Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions. Natural product reports, 2020, 03-25, Volume: 37, Issue:3 Topics: Amino Acids; Benzoic Acid; Cyclopropanes; Hydroxylation; Lactams; Macrolides; Netropsin; Peptide Synthases; Proline; Protein Interaction Maps; Pyrroles; Thiazoles; Thiones	2020

Other Studies

47 other study(ies) available for thiazoles and dc 107

Article	Year
DNA strand scission by the novel antitumor antibiotic leinamycin. Biochemistry, 1990, Jun-19, Volume: 29, Issue:24 Topics: Antibiotics, Antineoplastic; Bacillus; Dithiothreitol; DNA Damage; DNA, Bacterial; DNA, Single-Stranded; Lactams; Macrolides; Streptomyces; Thiazoles; Thiones	1990
Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation. The Journal of antibiotics, 1989, Volume: 42, Issue:12 Topics: Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Fermentation; Lactams; Macrolides; Streptomyces; Thiazoles; Thiones	1989
DC 107, a novel antitumor antibiotic produced by a Streptomyces sp. The Journal of antibiotics, 1989, Volume: 42, Issue:2 Topics: Antibiotics, Antineoplastic; Lactams; Macrolides; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Streptomyces; Thiazoles; Thiones	1989
1,2-Dithiolan-3-one 1-oxides: a class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin. Biochemistry, 1996, Feb-13, Volume: 35, Issue:6 Topics: Antibiotics, Antineoplastic; DNA; Lactams; Macrolides; Reactive Oxygen Species; Sulfhydryl Compounds; Thiazoles; Thiones; Thiophenes	1996
Thiol-independent DNA cleavage by a leinamycin degradation product. Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:4 Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Cattle; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; DNA Methylation; DNA, Single-Stranded; Electrophoresis, Agar Gel; Guanine; Hydrogen-Ion Concentration; Lactams; Macrolides; Magnetic Resonance Spectroscopy; Streptomyces; Sulfhydryl Compounds; Thiazoles; Thiones; Thymus Gland	1997
Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups. Bioorganic & medicinal chemistry letters, 1998, Apr-21, Volume: 8, Issue:8 Topics: Antibiotics, Antineoplastic; Cell Division; HeLa Cells; Humans; Indicators and Reagents; Lactams; Macrolides; Molecular Conformation; Molecular Structure; Structure-Activity Relationship; Thiazoles; Thiones	1998
Synthesis and antitumor activity of novel thioester derivatives of leinamycin. Journal of medicinal chemistry, 1999, Apr-22, Volume: 42, Issue:8 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Inhibitory Concentration 50; Lactams; Macrolides; Pyrans; Sarcoma 180; Structure-Activity Relationship; Thiazoles; Thiones; Tumor Cells, Cultured	1999
Thiol-dependent DNA cleavage by 3H-1,2-benzodithiol-3-one 1,1-dioxide. Bioorganic & medicinal chemistry letters, 2000, May-01, Volume: 10, Issue:9 Topics: Antibiotics, Antineoplastic; DNA Damage; DNA, Superhelical; Lactams; Macrolides; Oxidation-Reduction; Plasmids; Sulfhydryl Compounds; Thiazoles; Thiones	2000
Attractive through-space S-O interaction in the DNA-cleaving antitumor antibiotic leinamycin. The Journal of organic chemistry, 2000, Aug-11, Volume: 65, Issue:16 Topics: Antibiotics, Antineoplastic; Lactams; Macrolides; Models, Chemical; Molecular Conformation; Structure-Activity Relationship; Thiazoles; Thiones	2000
An adjacent thioester provides apical-directed stabilization to 3-isothiazolidinone 1-oxide heterocycles. Chemical research in toxicology, 2000, Volume: 13, Issue:12 Topics: Antibiotics, Antineoplastic; Heterocyclic Oxides; Lactams; Macrolides; Oxygen; Prodrugs; Sulfhydryl Compounds; Sulfur; Thiazoles; Thiones	2000
DNA alkylation by leinamycin can be triggered by cyanide and phosphines. Bioorganic & medicinal chemistry letters, 2001, Jun-18, Volume: 11, Issue:12 Topics: Alkylation; Antibiotics, Antineoplastic; Cyanides; DNA; DNA Damage; Electrophoresis, Polyacrylamide Gel; Lactams; Macrolides; Oligonucleotides; Phosphines; Plasmids; Thiazoles; Thiones	2001
Thiol-independent DNA alkylation by leinamycin. Journal of the American Chemical Society, 2001, Mar-07, Volume: 123, Issue:9 Topics: Alkylation; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; DNA; Hydrolysis; Lactams; Macrolides; Sulfhydryl Compounds; Thiazoles; Thiones	2001
Two (E,E)- and (Z,E)-thiazol-5-ylpenta-2,4-dienones. Acta crystallographica. Section C, Crystal structure communications, 2002, Volume: 58, Issue:Pt 8 Topics: Alkenes; Alkylation; Antibiotics, Antineoplastic; Crystallography, X-Ray; DNA; Hydrogen Bonding; Lactams; Macrolides; Models, Molecular; Thiazoles; Thiones	2002
Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140. Journal of bacteriology, 2002, Volume: 184, Issue:24 Topics: Amino Acid Sequence; Antibiotics, Antineoplastic; Chromosome Mapping; Cloning, Molecular; Cysteine; Genes, Bacterial; Lactams; Macrolides; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Peptide Synthases; Polymerase Chain Reaction; Streptomyces; Thiazoles; Thiones	2002
Activation of leinamycin by thiols: a theoretical study. The Journal of organic chemistry, 2002, Dec-13, Volume: 67, Issue:25 Topics: Antibiotics, Antineoplastic; Lactams; Macrolides; Models, Theoretical; Molecular Conformation; Molecular Structure; Structure-Activity Relationship; Sulfhydryl Compounds; Thiazoles; Thiones	2002
Synthesis and antitumor activity of novel C-8 ester derivatives of leinamycin. Bioorganic & medicinal chemistry letters, 2003, Feb-10, Volume: 13, Issue:3 Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Esters; HeLa Cells; Humans; Lactams; Leukemia P388; Macrolides; Mice; Mice, Nude; Sarcoma 180; Structure-Activity Relationship; Thiazoles; Thiones	2003
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 2003, Mar-18, Volume: 100, Issue:6 Topics: Antibiotics, Antineoplastic; Base Sequence; DNA Primers; Escherichia coli; Genes, Bacterial; Lactams; Macrolides; Malonyl Coenzyme A; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Phylogeny; Protein Engineering; Protein Structure, Tertiary; Recombinant Proteins; Streptomyces; Thiazoles; Thiones	2003
Small molecules that mimic the thiol-triggered alkylating properties seen in the natural product leinamycin. Journal of the American Chemical Society, 2003, Apr-30, Volume: 125, Issue:17 Topics: Alkylating Agents; Antibiotics, Antineoplastic; Biomimetic Materials; Lactams; Macrolides; Structure-Activity Relationship; Sulfhydryl Compounds; Thiazoles; Thiones	2003
1,2-dithiolan-3-ones and derivatives structurally related to leinamycin. Synthesis and biological evaluation. Farmaco (Societa chimica italiana : 1989), 2003, Volume: 58, Issue:9 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 2-Ring; Humans; Lactams; Macrolides; Sulfhydryl Compounds; Thiazoles; Thiones	2003
Sequence specificity of DNA alkylation by the antitumor natural product leinamycin. Chemical research in toxicology, 2003, Volume: 16, Issue:12 Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Base Sequence; Binding Sites; Cattle; DNA; DNA, Single-Stranded; Fishes; Guanine; Lactams; Macrolides; Male; Molecular Sequence Data; Mustard Gas; Oligonucleotides; Perchlorates; Phosphoric Monoester Hydrolases; Plasmids; Sodium Compounds; Spermatozoa; Substrate Specificity; Sulfuric Acid Esters; Thiazoles; Thiones	2003
Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. Chemistry & biology, 2004, Volume: 11, Issue:1 Topics: Amino Acid Sequence; Antibiotics, Antineoplastic; Cloning, Molecular; Genes, Bacterial; Genes, Regulator; Lactams; Macrolides; Models, Genetic; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Peptide Synthases; Phylogeny; Sequence Alignment; Sequence Analysis; Streptomyces; Thiazoles; Thiones	2004
Chemical properties of the leinamycin-guanine adduct in DNA. Chemical research in toxicology, 2004, Volume: 17, Issue:7 Topics: Animals; Antineoplastic Agents, Alkylating; DNA; DNA Adducts; Guanidine; Lactams; Macrolides; Purines; Thiazoles; Thiones	2004
Cellular response and molecular mechanism of antitumor activity by leinamycin in MiaPaCa human pancreatic cancer cells. Anti-cancer drugs, 2004, Volume: 15, Issue:7 Topics: Antibiotics, Antineoplastic; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 2; DNA Damage; DNA, Neoplasm; Down-Regulation; Enzyme Activation; Flow Cytometry; Humans; Lactams; Macrolides; Pancreatic Neoplasms; Protein Serine-Threonine Kinases; Telomerase; Thiazoles; Thiones	2004
A fluorimetric assay for the spontaneous release of an N7-alkylguanine residue from duplex DNA. Bioorganic & medicinal chemistry letters, 2005, Apr-15, Volume: 15, Issue:8 Topics: DNA; DNA Adducts; Fluorometry; Guanine; Lactams; Macrolides; Nucleic Acid Heteroduplexes; Thiazoles; Thiones	2005
Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. Journal of natural products, 2006, Volume: 69, Issue:3 Topics: Antibiotics, Antineoplastic; Base Sequence; Lactams; Macrolides; Malonyl Coenzyme A; Models, Biological; Molecular Sequence Data; Molecular Structure; Polyketide Synthases; Streptomyces; Thiazoles; Thiones	2006
Synthesis and cytotoxicity of leinamycin antibiotic analogues. Journal of medicinal chemistry, 2006, Sep-07, Volume: 49, Issue:18 Topics: Antibiotics, Antineoplastic; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Lactams; Macrolides; Structure-Activity Relationship; Thiazoles; Thiones	2006
Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine. The Journal of biological chemistry, 2007, Jul-13, Volume: 282, Issue:28 Topics: Alanine; Bacterial Proteins; Carrier Proteins; Genes, Bacterial; Lactams; Macrolides; Multigene Family; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Synthases; Polyketide Synthases; Protein Structure, Tertiary; Streptomyces; Thiazoles; Thiones	2007
Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides. Organic & biomolecular chemistry, 2007, May-21, Volume: 5, Issue:10 Topics: Alkylating Agents; Antibiotics, Antineoplastic; Benzoic Acid; Carboxylic Acids; Chemistry, Pharmaceutical; DNA; Fluorides; Hydrogen-Ion Concentration; Ions; Lactams; Macrolides; Models, Chemical; Sulfhydryl Compounds; Sulfoxides; Thiazoles; Thiones	2007
Reactive sulfur species: kinetics and mechanism of the hydrolysis of cysteine thiosulfinate ester. Chemical research in toxicology, 2007, Volume: 20, Issue:9 Topics: Cysteine; Disulfides; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactams; Macrolides; Molecular Structure; Oxidation-Reduction; Sulfinic Acids; Sulfur; Thiazoles; Thiones; Thiosulfonic Acids	2007
Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin. Bioorganic & medicinal chemistry letters, 2008, May-15, Volume: 18, Issue:10 Topics: Antineoplastic Agents; DNA; DNA Damage; Lactams; Macrolides; Models, Biological; Molecular Structure; Reactive Oxygen Species; Sulfhydryl Compounds; Sulfides; Thiazoles; Thiones	2008
Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis. Journal of the American Chemical Society, 2009, May-27, Volume: 131, Issue:20 Topics: Acyltransferases; Alkylation; Carboxy-Lyases; Hydroxymethylglutaryl-CoA Synthase; Lactams; Macrolides; Thiazoles; Thiones	2009
Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Comet Assay; DNA Adducts; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Damage; Fluorescent Dyes; Humans; Lactams; Macrolides; Oxidative Stress; Reactive Oxygen Species; Thiazoles; Thiones	2010
Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis. Organic letters, 2011, Feb-04, Volume: 13, Issue:3 Topics: Alkylation; Lactams; Macrolides; Molecular Structure; Polyketide Synthases; Stereoisomerism; Streptomyces; Thiazoles; Thiones	2011
Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator. Journal of the American Chemical Society, 2011, Nov-09, Volume: 133, Issue:44 Topics: Alkylation; Binding Sites; Biological Products; Daunorubicin; DNA; Lactams; Macrolides; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Thiazoles; Thiones	2011
The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product. Bioorganic & medicinal chemistry letters, 2012, Jun-01, Volume: 22, Issue:11 Topics: Biological Products; DNA; DNA Cleavage; DNA Damage; Hydrolysis; Lactams; Macrolides; Oxides; Sulfhydryl Compounds; Thiazoles; Thiones	2012
DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences. Bioorganic & medicinal chemistry, 2012, Jul-15, Volume: 20, Issue:14 Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Cricetinae; DNA; DNA Cleavage; DNA Repair; Hydroxylamines; Lactams; Macrolides; Thiazoles; Thiones	2012
Synthesis and characterization of a small analogue of the anticancer natural product leinamycin. Bioorganic & medicinal chemistry, 2013, Jan-01, Volume: 21, Issue:1 Topics: Alkylation; Antineoplastic Agents; Biological Products; DNA; DNA Cleavage; Humans; Lactams; Macrolides; Neoplasms; Oxidation-Reduction; Streptomyces; Sulfhydryl Compounds; Thiazoles; Thiones	2013
Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. Biochemistry, 2013, Feb-05, Volume: 52, Issue:5 Topics: Acyltransferases; Antibiotics, Antineoplastic; Carboxy-Lyases; Catalytic Domain; Crystallography, X-Ray; Lactams; Macrolides; Models, Molecular; Protein Conformation; Protein Folding; Streptomyces; Thiazoles; Thiones	2013
Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America, 2015, Jul-07, Volume: 112, Issue:27 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Lactams; Macrolides; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Prodrugs; Prostatic Neoplasms; Reactive Oxygen Species; Streptomyces; Thiazoles; Thiones	2015
C-S bond cleavage by a polyketide synthase domain. Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-18, Volume: 112, Issue:33 Topics: Antibiotics, Antineoplastic; Carbon; Carbon-Sulfur Lyases; Computational Biology; Cysteine; Drug Design; Lactams; Macrolides; Multigene Family; Phylogeny; Polyketide Synthases; Polyketides; Protein Engineering; Protein Structure, Tertiary; Streptomyces; Substrate Specificity; Sulfhydryl Compounds; Sulfides; Thiazoles; Thiones	2015
Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis. Organic letters, 2016, 09-02, Volume: 18, Issue:17 Topics: Acyl Carrier Protein; Lactams; Macrolides; Molecular Conformation; Peptide Synthases; Polyketide Synthases; Protein Domains; Thiazoles; Thiones	2016
Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement. Applied microbiology and biotechnology, 2016, Volume: 100, Issue:24 Topics: Antineoplastic Agents; Bacterial Proteins; Biosynthetic Pathways; Computational Biology; Gene Expression; Gene Silencing; Genes, Regulator; Lactams; Macrolides; Metabolic Engineering; Multigene Family; Sequence Homology, Amino Acid; Streptomyces; Thiazoles; Thiones; Transcription Factors	2016
Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proceedings of the National Academy of Sciences of the United States of America, 2017, 12-26, Volume: 114, Issue:52 Topics: Actinobacteria; Bacterial Proteins; Computational Biology; Genes, Bacterial; Lactams; Macrolides; Multigene Family; Phylogeny; Thiazoles; Thiones	2017
P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. Biochemistry, 2018, 08-21, Volume: 57, Issue:33 Topics: Antibiotics, Antineoplastic; Biosynthetic Pathways; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Escherichia coli; Gene Silencing; Humans; Hydroxylation; Lactams; Lactams, Macrocyclic; Macrolides; Molecular Structure; Multigene Family; Stereoisomerism; Streptomyces; Structure-Activity Relationship; Thiazoles; Thiones	2018
Discovery of Cryptic Largimycins in ACS chemical biology, 2020, 06-19, Volume: 15, Issue:6 Topics: Biosynthetic Pathways; Drug Discovery; Genes, Bacterial; Lactams; Macrolides; Molecular Structure; Multigene Family; Streptomyces; Thiazoles; Thiones	2020
Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase. Nature communications, 2021, 09-28, Volume: 12, Issue:1 Topics: Animals; Biological Products; Carbon-Sulfur Lyases; Cysteine; Cystine; Humans; Lactams; Macrolides; Methyltransferases; Models, Chemical; Molecular Structure; Peptide Synthases; Polyketide Synthases; src Homology Domains; Streptomyces; Substrate Specificity; Sulfides; Thiazoles; Thiones	2021
Biosynthesis of Largimycins in ACS chemical biology, 2022, 08-19, Volume: 17, Issue:8 Topics: Alkylation; Halogenation; Lactams; Macrolides; Multigene Family; Streptomyces; Thiazoles; Thiones	2022