thiazoles has been researched along with cytochrome c-t in 90 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 64 (71.11) | 29.6817 |
| 2010's | 25 (27.78) | 24.3611 |
| 2020's | 1 (1.11) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, A; Hoffman, RM; Miki, K; Moossa, AR; Tomita, K; Tsuchiya, H; Tsujimoto, Y; Xu, M; Yamamoto, N | 1 |
| Bardini, P; Danni, O; Guglielmotto, M; Marra, L; Parola, M; Santoro, G; Tabaton, M; Tamagno, E | 1 |
| Casero, RA; Davidson, NE; Dunn, VR; Frydman, B; Hacker, A; Hager, ER; Huang, Y; Kink, JA; Marton, LJ; Phillips, DL; Reddy, VK; Valasinas, AL | 1 |
| Hockenbery, DM; O'Neill, JW | 1 |
| Tang, W; Yao, Y | 1 |
| Bet, A; Carli, M; Dalla Vecchia, F; Diaspro, A; Gatto, B; Palù, G; Palumbo, M; Pecere, T; Salata, C; Sarinella, F | 1 |
| Brenden, H; Felsner, I; Grether-Beck, S; Krutmann, J | 1 |
| Gentil, B; Grimot, F; Riva, C | 1 |
| Bonini, P; Cardinale, A; Cicconi, S; Ciotti, MT; Marlier, LN; Serafino, AL; Vitale, C | 1 |
| Chae, IH; Kim, HS; Oh, BH; Park, KW | 1 |
| Damdimopoulos, AE; Nalvarte, I; Spyrou, G | 1 |
| Fuentes, JM; González-Polo, RA; Morán, JM; Niso, M; Rodríguez-Martín, A; Soler, G | 1 |
| Corey, SJ; Dai, Y; Dent, P; Grant, S; Rahmani, M | 1 |
| Halliwell, B; Jenner, A; Peng, ZF; Tang, SY; Whiteman, M | 1 |
| Arriaza, E; Cara, C; Di Paola, M; Escribano, O; Fernández-Moreno, MD; Fueyo, JA; Guijarro, LG; Lorusso, M; Menor, C; Olleros, T; Román, ID | 1 |
| Ralphe, JC; Scholz, TD; Schutte, BC; Segar, JL | 1 |
| Avetisyan, AV; Chernyak, BV; Izyumov, DS; Pletjushkina, OY; Sakharov, DV; Skulachev, VP; Wirtz, KW | 1 |
| Cho, JS; Hwang, DY; Kim, YK; Lim, CJ | 1 |
| Andrieu-Abadie, N; Autefage, H; Garcia, V; Levade, T; Tardy, C | 1 |
| Emami, A; Gordon, JD; Park, SJ; Safa, AR; Wu, CH; Zhong, X | 1 |
| Cooper, JM; Gu, M; Iravani, MM; Irvani, M; Jenner, P; King, D; Schapira, AH | 1 |
| Csapo, Z; Keszler, G; Sasvari-Szekely, M; Spasokoukotskaja, T; Staub, M; Virga, S | 1 |
| Bosco, MC; Melillo, G; Pastorino, S; Pezzolo, A; Puppo, M; Varesio, L | 1 |
| Hyman, AA; Knorre, DA; Markova, OV; Pozniakovsky, AI; Severin, FF; Skulachev, VP | 1 |
| Do, BR; Hwang, MS; Jung, HK; Kim, H; Kim, HT; Kim, J; Kim, JH; Kim, KS; Kim, OH; Kim, SH; Ko, JK; Koh, SH; Kwon, H; Park, KH; Roh, H; Yu, HJ; Yum, YN | 1 |
| Antonsson, B; Carboni, S; Gaillard, P; Gillon, JY; Gotteland, JP; Vitte, PA | 1 |
| Ando, K; Chang, YC; Furukawa, C; Magae, J; Mizuta, N; Nakajima, H; Ozawa, S; Sakaguchi, K; Yamagishi, H | 1 |
| Alsina, M; Beam, C; Beaupre, DM; Dalton, W; Gerbino, E; Hamilton, AD; Kerr, WG; Lichtenheld, MG; Mackley, PA; Muro-Cacho, C; Sebti, SM; Zhu, K | 1 |
| Davis, JJ; Fang, B; Sasaki, J; Teraishi, F; Wu, S; Zhang, L; Zhu, HB | 1 |
| Cole, MP; Humphrey, ML; Kiningham, KK; Pendergrass, JC | 1 |
| Cooper, JM; Gu, M; Hartley, JA; Hochhauser, D; Lo, S; Schapira, AH; Taanman, JW; Tolner, B | 1 |
| Kim, HJ; Kim, J; Kim, KS; Kim, M; Kim, SH; Koh, SH; Lee, KW; Lee, YB; Lee, YJ | 1 |
| Diolordi, L; Gilardini Montani, MS; Natoni, F; Santoni, C | 1 |
| Cardoso, SM; Oliveira, CR; Pereira, C; Rego, AC | 1 |
| Basma, H; Cheng, PW; Cowan, KH; El-Refaey, H; Luo, X; Sgagias, MK | 1 |
| Bienengraeber, MW; Bosnjak, ZJ; Jamnicki-Abegg, M; Kersten, JR; Pagel, PS; Warltier, DC; Weihrauch, D | 1 |
| Ali, N; Fujita, Y; Hamano, S; Izawa, Y; Kanematsu, Y; Tamaki, T; Tsuchiya, K; Yoshizumi, M | 1 |
| Kim, HW; Kim, YJ; Lee, DH; Lee, H; Park, T; Sung, MK | 1 |
| Chua, BH; Chua, CC; Gao, J; Hamdy, RC; Liu, X | 1 |
| Denizeau, F; Jumarie, C; Marion, M; Pham, TN | 1 |
| Costa, FT; de Carvalho, DD; Duran, N; Haun, M | 1 |
| Fu, YR; Qiu, ZY; Yan, YR; Yi, ZJ | 1 |
| Han, CR; Jeong, YJ; Jung, JY; Kim, HJ; Kim, SH; Kim, WJ; Lee, KH; Lim, HS; Oh, WM; Park, HO | 1 |
| Doherty, GH | 1 |
| Azuma, H; Ijichi, S; Izumi, T; Kataoka, M; Masuda, A; Tachibana, T; Yoshimoto, T | 1 |
| Hwang, S; Kim, HY; Kim, SH; Kim, Y; Koh, SH; Lee, CH | 1 |
| Bhutia, SK; Maiti, TK; Mallick, SK; Prokai, L; Stevens, SM; Vishwanatha, JK | 1 |
| Baert, B; Baysse, C; Cornelis, P; Matthijs, S | 1 |
| Bellance, N; Benard, G; Casteilla, L; Faustin, B; Galinier, A; Letellier, T; Rocher, C; Rossignol, R; Smolkova, K | 1 |
| Chang, TT; Chen, CH; Hung, RP; Lin, ML; Lu, FJ; Ong, PL; Weng, BC | 1 |
| Belkhiri, A; Castells, A; Correa, P; Dar, AA; El-Rifai, W; Koyama, T; Pera, M; Piazuelo, MB; Washington, K; Zaika, A | 1 |
| Halliwell, B; Ng, LE; Wong, KP | 1 |
| Cho, HJ; Chung, SY; Kim, HJ; Kim, Y; Kim, YK; Lee, JH; Park, R; So, HS; Sohn, JS; Youn, MJ | 1 |
| Almasan, A; Mazumder, S; Plesca, D | 1 |
| Du, Y; Fan, X; Le, W; Li, X; Luo, G; Yang, D | 1 |
| Hothersall, JS; Papakyriakou, A; Theodossiou, TA | 1 |
| Fukuhara, K; Hiraku, Y; Kobayashi, H; Murata, M; Oikawa, S; Tada-Oikawa, S; Yada, Y | 1 |
| Ahmed, K; Kondo, T; Matsuya, Y; Nemoto, H; Shimizu, T; Sugiyama, T; Yoshihisa, Y; Zaidi, SF | 1 |
| He, GX; He, HB; Li, Y; Li, YL; Liu, HR; Liu, YL; Peng, XD; Wang, YH; Zeng, CJ | 1 |
| Heneka, MT; Hermes, M; Kummer, MP; Orlandi, M; Papi, A; Tatenhorst, L; Terwel, D | 1 |
| Cortés, L; de Diego, AM; Egea, J; García, AG; González, JC; Hernández-Guijo, JM; López, MG; Mosquera, M; Nicolau, SM | 1 |
| Choi, H; Choi, N; Gook, E; Jung, B; Kim, I; Kim, J; Kim, JH; Kim, M; Kim, O; Kim, S; Ko, Y; Kwon, H; Lim, H; Lim, W; Yang, K | 1 |
| Gan, YH; Zhang, S | 1 |
| Galindo, MF; Jordán, J; Manzanares, J; Perez-Alvarez, S; Solesio, ME | 1 |
| Aponte, AM; Murphy, E; Steenbergen, C; Wong, R | 1 |
| Chan, KM; Chow, SC; Din, LB; Farzaneh, F; Inayat-Hussain, SH; Kizilors, A; Rajab, NF; Williams, GT | 1 |
| Carniglia, L; Caruso, C; Durand, D; Lasaga, M | 1 |
| Abajian, M; Ripple, MO; Springett, R | 1 |
| Cho, SW; Choi, SY; Hahn, HG; Kim, EA; Kim, KS; Kim, TU | 1 |
| Amit, T; Bar-Am, O; Bloch, K; Mandel, SA; Mechlovich, D; Vardi, P; Youdim, MB | 1 |
| Liu, X; Wang, Y; Xu, K; Yan, M; Zheng, X | 1 |
| Ashok Kumar, R; Guha, G; Mandal, T; Rajkumar, V | 1 |
| Cai, D; Dong, M; Fan, L; Li, C; Li, X; Liu, J; Niu, Y; Wang, X; Xing, G; Zhou, L; Zou, Y | 1 |
| Ban, JY; Cho, JO; Chun, GS; Chung, JH; Kang, SW; Park, HJ | 1 |
| Pham, L; Tai, KK; Truong, DD | 1 |
| Kanno, T; Nishizaki, T | 1 |
| Liu, C; Sun, J; Wei, J; Xu, Z | 1 |
| Abad, MA; Ceña, V; López-Hernández, B; Podlesniy, P; Posadas, I; Trullas, R | 1 |
| Chen, WD; Deng, R; Feng, GK; Lan, WJ; Li, DD; Li, HJ; Tang, J; Wu, KW; Yang, F; Zhang, H; Zhu, XF | 1 |
| Amani, S; Naeem, A | 2 |
| Abbott, G; Beall, HD; Diaz, P; Duncan, NS; Eickholt, EA; Kearns, AK; Keyari, CM | 1 |
| Fang, B; Kang, Y; Liu, X; Qin, J; Xu, Z; Zang, C | 1 |
| Angeles Anguiano, E; Escutia Calzada, D; Frías González, SE; Mendoza Herrera, A; Ordaz Pichardo, C | 1 |
| Bi, Y; Jiang, Y; Khan, M; Ma, T; Meng, F; Yang, C; Yang, H; Yang, J; Yu, B; Zhou, Y | 1 |
| Li, G; Wang, Y; Xie, X; Yu, H; Zhang, J | 1 |
| Chen, JH; Chou, FP; Chyau, CC; Hsuan, SW; Hung, HY | 1 |
| Dionisio, G; Etzerodt, T; Rayment, I; Wetterhorn, K | 1 |
| Gu, W; Shan, Y; Wang, S; Wang, Y; Wu, C; Zhang, Q | 1 |
| Alazragi, R; El-Sherbeeny, NA; Elaidy, SM; Helmi, N; Salem, N; Tantawy, MA | 1 |
1 review(s) available for thiazoles and cytochrome c-t
| Article | Year |
|---|---|
Bcl-2-related proteins as drug targets.
Topics: Animals; Antimycin A; Apoptosis; Benzamides; Benzopyrans; Cytochromes c; Enzyme Inhibitors; Humans; Ion Channels; Mitochondria; Models, Molecular; Nitriles; Peptides; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Thiazoles | 2003 |
89 other study(ies) available for thiazoles and cytochrome c-t
| Article | Year |
|---|---|
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
Topics: Apoptosis; Bisbenzimidazole; Blotting, Western; Carbon-Sulfur Lyases; Cell Line, Tumor; Cell Nucleus; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Genetic Therapy; Humans; Lung Neoplasms; Mitochondria; Models, Biological; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pseudomonas putida; Selenomethionine; Staurosporine; Tetrazolium Salts; Thiazoles; Transfection | 2003 |
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.
Topics: Acetylcysteine; alpha-Tocopherol; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cell Differentiation; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Caspases; Cell Death; Cell Division; Cell Line, Tumor; Cell Nucleus; Cell Survival; Chromatin; Cytochromes c; Cytoplasm; Cytosol; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Models, Chemical; Neoplasm Transplantation; Nucleosomes; Poly(ADP-ribose) Polymerases; Polyamines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Tetrazolium Salts; Thiazoles; Time Factors; Up-Regulation | 2003 |
NMR investigation of the alkaline-like conformational transition of horse heart cytochrome c in the presence of exogenous thiazole.
Topics: Alkalies; Animals; Cytochromes c; Heart; Heme; Horses; Hydrogen-Ion Concentration; Isomerism; Ligands; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Protein Conformation; Protons; Thiazoles; Titrimetry | 2003 |
Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.
Topics: Anthraquinones; Apoptosis; Benzothiazoles; Blotting, Western; Caspases; Cell Cycle; Child, Preschool; Cytochromes c; DNA Primers; DNA Topoisomerases, Type II; DNA, Neoplasm; Emodin; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Male; Microscopy, Immunoelectron; Mitochondria; Mutation; Neuroectodermal Tumors; Poly(ADP-ribose) Polymerases; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
Mitochondrial cytochrome c release mediates ceramide-induced activator protein 2 activation and gene expression in keratinocytes.
Topics: Apoptosis; Atractyloside; Blotting, Western; Cell Line; Cell Survival; Cells, Cultured; Ceramides; Coloring Agents; Cytochromes c; Cytoplasm; DNA; DNA-Binding Proteins; Electron Transport; Fibroblasts; Glutathione; HeLa Cells; Humans; Intercellular Adhesion Molecule-1; Keratinocytes; Mitochondria; Oxygen; Precipitin Tests; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factor AP-2; Transcription Factors | 2003 |
Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Survival; Ceramides; Coloring Agents; Cytochromes c; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Electron Transport; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; Humans; Microscopy, Fluorescence; Mitochondria; Reactive Oxygen Species; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Astrocytes; Benzothiazoles; Blotting, Northern; Cell Survival; Cells, Cultured; Cytochromes c; Embryo, Mammalian; Fluorescent Antibody Technique; Genes, bcl-2; Hydrogen Peroxide; Microscopy, Confocal; Mitochondria; Models, Biological; Neuroprotective Agents; Nuclear Proteins; Nucleosomes; Oxidants; Oxidative Stress; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Time Factors; Toluene; Tumor Suppressor Protein p53 | 2004 |
Nitric oxide-induced apoptosis is mediated by Bax/Bcl-2 gene expression, transition of cytochrome c, and activation of caspase-3 in rat vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspases; Cell Count; Cell Survival; Cells, Cultured; Cytochromes c; Cytoplasm; Enzyme Activation; Flow Cytometry; Gene Expression; Genes, bcl-2; In Situ Nick-End Labeling; Male; Mitochondria, Muscle; Muscle, Smooth, Vascular; Nitric Oxide; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles | 2004 |
Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antimycin A; Cell Division; Cell Survival; Cells, Cultured; Cytochromes c; Electron Transport; Electron Transport Complex III; Humans; Kidney; Methacrylates; Mitochondria; NAD; NADP; Selenocysteine; Thiazoles; Thioredoxin Reductase 1; Thioredoxin Reductase 2; Thioredoxin-Disulfide Reductase; Thioredoxins | 2004 |
Paraquat-induced apoptotic cell death in cerebellar granule cells.
Topics: Allopurinol; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cells, Cultured; Cerebellum; Cytochromes c; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Herbicides; In Situ Nick-End Labeling; Male; Mitochondria; Models, Biological; Neurons; Paraquat; Piperazines; Rats; Tetrazolium Salts; Thiazoles; Time Factors; Vitamin E | 2004 |
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.
Topics: Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; bcl-X Protein; Benzamides; Blotting, Western; Cell Line; Cell Line, Tumor; Coloring Agents; Cytochromes c; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flavoproteins; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Membrane Potentials; Membrane Proteins; Milk Proteins; Mitochondria; Mutation; Piperazines; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; src-Family Kinases; STAT5 Transcription Factor; Tetrazolium Salts; Thiazoles; Trans-Activators; Transfection; Up-Regulation | 2004 |
Mechanism of cell death induced by an antioxidant extract of Cratoxylum cochinchinense (YCT) in Jurkat T cells: the role of reactive oxygen species and calcium.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Blotting, Western; Calcium; Caspase 3; Caspase 9; Caspases; Cell Adhesion; Cell Line; Cell Membrane; Cell Survival; Clusiaceae; Coloring Agents; Cytochromes c; DNA Fragmentation; Dogs; Ferricyanides; Flow Cytometry; Glutathione; HL-60 Cells; Humans; Jurkat Cells; Lymphocytes; Membrane Potentials; Mitochondria; Models, Biological; Nucleosomes; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Phosphatidylserines; Plant Extracts; Rats; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors; Trypan Blue | 2004 |
Azathioprine acts upon rat hepatocyte mitochondria and stress-activated protein kinases leading to necrosis: protective role of N-acetyl-L-cysteine.
Topics: Acetylcysteine; Animals; Apoptosis; Azathioprine; Caspase 3; Caspases; Cell Survival; Cytochromes c; DNA; DNA Fragmentation; Glutathione; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Male; Mitochondria, Liver; Mitogen-Activated Protein Kinase 3; Necrosis; Oxygen Consumption; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Stress, Physiological; Superoxides; Tetrazolium Salts; Thiazoles; Thymidine; Tritium | 2004 |
Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria.
Topics: Adenoviridae; Animals; Aspartic Acid; Blotting, Northern; Brain; Cells, Cultured; Coloring Agents; Cytochromes c; Digitonin; DNA, Complementary; Excitatory Amino Acid Transporter 1; Genetic Vectors; Glutamic Acid; Hypoxia; Immunoblotting; Immunohistochemistry; Malates; Microscopy, Fluorescence; Mitochondria; Mitochondria, Heart; Myocardium; Open Reading Frames; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Transfection | 2004 |
"Wages of fear": transient threefold decrease in intracellular ATP level imposes apoptosis.
Topics: Adenosine Triphosphate; Apoptosis; bcl-2-Associated X Protein; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Caspases; Cytochromes c; Cytosol; Deoxyglucose; Enzyme Inhibitors; HeLa Cells; Humans; Intracellular Space; Methacrylates; Mitochondria; Oligomycins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Thiazoles | 2004 |
Mutant nicastrin protein can induce the cytochrome c release and the Bax expression.
Topics: Amyloid Precursor Protein Secretases; bcl-2-Associated X Protein; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Survival; Cytochromes c; DNA Mutational Analysis; Gene Expression Regulation; Humans; Membrane Glycoproteins; Mitochondria; Mutagenesis, Site-Directed; Mutation; Neuroblastoma; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles; Transfection | 2004 |
Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts.
Topics: Aminopeptidases; Animals; Apoptosis; Carboxypeptidases; Cathepsin B; Cathepsin L; Cathepsins; Cell Death; Cell Line, Transformed; Cell Survival; Coloring Agents; Culture Media; Cysteine Endopeptidases; Cytochromes c; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dose-Response Relationship, Drug; Endopeptidases; Fas Ligand Protein; fas Receptor; Fibroblasts; Flow Cytometry; Golgi Apparatus; Humans; Intercellular Adhesion Molecule-1; Lymphocytes; Lysosomes; Mannosephosphates; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Mucolipidoses; Phenotype; Phosphorylation; Recombinant Proteins; Signal Transduction; Skin; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Taxol induces caspase-10-dependent apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Annexin A5; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carrier Proteins; Caspase 10; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fas-Associated Death Domain Protein; Flow Cytometry; Genes, Dominant; Humans; Intracellular Signaling Peptides and Proteins; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Models, Biological; Paclitaxel; Plasmids; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptors, Tumor Necrosis Factor, Type I; Tetrazolium Salts; Thiazoles; Transfection | 2004 |
Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms.
Topics: 1-Methyl-4-phenylpyridinium; Aconitate Hydratase; Antioxidants; Benzothiazoles; Carbocyanines; Caspase 3; Caspases; Cell Count; Cell Death; Cell Line, Tumor; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Flow Cytometry; Humans; Jurkat Cells; L-Lactate Dehydrogenase; Mitochondria; Necrosis; Neuroblastoma; Pramipexole; Rotenone; Thiazoles | 2004 |
Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cells, Cultured; Cladribine; Cytochromes c; Deoxycytidine Kinase; DNA Repair; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Lymphocytes; Models, Biological; Palatine Tonsil; Phosphotransferases (Alcohol Group Acceptor); Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2004 |
Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation.
Topics: Apoptosis; Bromodeoxyuridine; Caspases; Cell Hypoxia; Cell Survival; Cyclin-Dependent Kinases; Cytochromes c; DNA; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; G1 Phase; G2 Phase; Genes, myc; Growth Inhibitors; Humans; Hypoxia; In Situ Nick-End Labeling; Neuroblastoma; Piperidines; Proto-Oncogene Mas; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2004 |
Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast.
Topics: Amiodarone; Antifungal Agents; Antimycin A; Apoptosis; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cytochromes c; DNA Fragmentation; Kinetics; Mating Factor; Membrane Potentials; Methacrylates; Mitochondria; Mitochondrial Proteins; Models, Biological; Oxygen; Peptides; Pheromones; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiazoles | 2005 |
Protective effect of diallyl disulfide on oxidative stress-injured neuronally differentiated PC12 cells.
Topics: Allyl Compounds; Animals; Antihypertensive Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Count; Cell Differentiation; Cell Survival; Chromones; Cytochromes c; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluoresceins; Gene Expression Regulation; Glycogen Synthase Kinase 3; Hydrogen Peroxide; Indoles; Membrane Glycoproteins; Morpholines; Neurons; Oxidative Stress; PC12 Cells; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Tetrazolium Salts; Thiazoles; Thiobarbituric Acid Reactive Substances; Trypan Blue | 2005 |
Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurones following global transient ischaemia.
Topics: Acetonitriles; Analysis of Variance; Animals; Apoptosis; Benzothiazoles; Caspases; Cytochromes c; Enzyme Activation; Gerbillinae; Hippocampus; In Situ Nick-End Labeling; Ischemic Attack, Transient; JNK Mitogen-Activated Protein Kinases; Male; Mitochondria; Neurons; Reperfusion Injury; Thiazoles; Time Factors | 2005 |
Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines.
Topics: Alkenes; Apoptosis; Blotting, Western; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Survival; Coloring Agents; Cytochromes c; DNA Damage; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Luciferases; Phenols; Plasmids; Receptors, Estrogen; Tetrazolium Salts; Thiazoles | 2005 |
Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bone Marrow Cells; Caspase 3; Caspases; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Cisplatin; Clinical Trials as Topic; Cytochromes c; Deoxycytidine; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Enzyme Activation; Farnesyltranstransferase; Flow Cytometry; Fluorouracil; G2 Phase; Gemcitabine; Homozygote; Humans; In Situ Nick-End Labeling; Inhibitory Concentration 50; Mice; Mice, SCID; Mitosis; Multiple Myeloma; Paclitaxel; Quinolones; Taxoids; Tetrazolium Salts; Thiazoles | 2005 |
P-glycoprotein-independent apoptosis induction by a novel synthetic compound, MMPT [5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone].
Topics: Aniline Compounds; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Bone Marrow Cells; Caspases; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Enzyme Activation; Fibroblasts; Flow Cytometry; Genes, MDR; Genes, p53; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Paclitaxel; Proto-Oncogene Proteins c-jun; Thiazoles | 2005 |
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH).
Topics: Antifungal Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Caspase 3; Caspase 9; Caspases; Cell Death; Cell Line, Tumor; Cytochromes c; Humans; L-Lactate Dehydrogenase; Microscopy, Fluorescence; Mitochondria; Neuroblastoma; Poly(ADP-ribose) Polymerases; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Thimerosal | 2005 |
Assessment of the significance of mitochondrial DNA damage by chemotherapeutic agents.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Blotting, Southern; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Daunorubicin; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Mitochondrial; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Immunoblotting; Inhibitory Concentration 50; Intracellular Membranes; Membrane Potentials; Pyridines; Thiazoles; Tumor Suppressor Protein p53 | 2005 |
Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene.
Topics: Alanine; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Survival; Collagen Type XI; Cytochromes c; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heat-Shock Proteins; Humans; Hybrid Cells; Indoles; Motor Neurons; Mutagenesis; Neuroblastoma; Phosphatidylinositol 3-Kinases; Point Mutation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Trypan Blue; Valine | 2005 |
Sodium butyrate sensitises human pancreatic cancer cells to both the intrinsic and the extrinsic apoptotic pathways.
Topics: Apoptosis; bcl-X Protein; Blotting, Western; Butyrates; Caspases; Cell Line, Tumor; Cytochromes c; DNA Primers; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Mitochondrial Membranes; Pancreatic Neoplasms; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles | 2005 |
Protective effect of zinc on amyloid-beta 25-35 and 1-40 mediated toxicity.
Topics: Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Cell Line; Coloring Agents; Congo Red; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Microscopy, Confocal; Mitochondria; Neurotoxins; Peptide Fragments; Protein Structure, Secondary; Thiazoles; Zinc | 2005 |
BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caspase 8; Caspases; Cell Line, Tumor; Cell Survival; Cisplatin; Cytochromes c; fas Receptor; Gene Transfer Techniques; Genes, p53; Genetic Therapy; Humans; Inhibitory Concentration 50; Liposomes; Models, Statistical; Necrosis; Oligonucleotides, Antisense; Phosphatidylethanolamines; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles; Transfection; Transferrin; Tumor Suppressor Protein p53 | 2005 |
Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Biotransformation; Caspases; Cell Line; Cell Separation; Cytochromes c; Dogs; Genes, bcl-2; Hydrogen Peroxide; Hypoxia; In Situ Nick-End Labeling; Inflammation; Isoflurane; L-Lactate Dehydrogenase; Male; Myocytes, Cardiac; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Tetrazolium Salts; Thiazoles | 2005 |
Pramipexole protects against H2O2-induced PC12 cell death.
Topics: Animals; Antiparkinson Agents; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Cell Death; Cell Survival; Cytochromes c; Dopamine Agonists; Dopamine Antagonists; Hydrogen Peroxide; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Pramipexole; Rats; Thiazoles | 2006 |
Induction of apoptosis by Cordyceps militaris through activation of caspase-3 in leukemia HL-60 cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Proliferation; Cell Survival; Cordyceps; Cytochromes c; DNA Fragmentation; DNA, Neoplasm; Electrophoresis; Enzyme Activation; HL-60 Cells; Humans; Poly(ADP-ribose) Polymerases; Tetrazolium Salts; Thiazoles | 2006 |
Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Benzothiazoles; Blotting, Western; Caspases; Cell Line, Tumor; Cytochromes c; Doxorubicin; Electrophoretic Mobility Shift Assay; Energy Metabolism; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; fas Receptor; Genes, p53; Mitogen-Activated Protein Kinases; Myocardium; Neoplasms, Muscle Tissue; Oxidative Stress; Phosphorylation; Poly(ADP-ribose) Polymerases; Rats; Thiazoles; Toluene | 2006 |
Cadmium-induced apoptosis in rat hepatocytes does not necessarily involve caspase-dependent pathways.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Bisbenzimidazole; Cadmium; Caspase 3; Caspases; Cell Separation; Cell Survival; Cells, Cultured; Chromatin; Cytochromes c; Cytosol; DNA; DNA Fragmentation; Hepatocytes; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazolium Salts; Thiazoles | 2006 |
Cytotoxic activity of violacein in human colon cancer cells.
Topics: Apoptosis; Caco-2 Cells; Calcium; Caspase 3; Cell Death; Cell Survival; Colonic Neoplasms; Cytochromes c; Enzyme Activation; HT29 Cells; Humans; Indicators and Reagents; Indoles; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2006 |
Hydroxycamptothecin-induced apoptosis in hepatoma SMMC-7721 cells and the role of mitochondrial pathway.
Topics: Apoptosis; Apoptosis Inducing Factor; Camptothecin; Cell Line, Tumor; Cell Survival; Cytochromes c; Cytoplasm; DNA Fragmentation; Enzyme Inhibitors; Hepatocytes; Humans; Membrane Potential, Mitochondrial; Mitochondria; Tetrazolium Salts; Thiazoles | 2006 |
Epigallocatechin gallate inhibits nitric oxide-induced apoptosis in rat PC12 cells.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspases; Catechin; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors; Voltage-Dependent Anion Channels | 2007 |
Developmental switch in the effects of TNFalpha on ventral midbrain dopaminergic neurons.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cytochromes c; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Floxuridine; Glial Fibrillary Acidic Protein; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Peptides, Cyclic; Pregnancy; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2007 |
Short-chain 3-ketoceramides, strong apoptosis inducers against human leukemia HL-60 cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Ceramides; Cytochromes c; Cytosol; DNA Fragmentation; Enzyme Activation; Glutathione; HL-60 Cells; Humans; Immunoblotting; Indicators and Reagents; Mitochondria; Reactive Oxygen Species; Signal Transduction; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles | 2007 |
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Caspase 3; Cell Death; Cyclooxygenase 2; Cytochromes c; Cytosol; Disease Progression; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Mice; Mice, Transgenic; Motor Neurons; Poly(ADP-ribose) Polymerases; Postural Balance; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Urea | 2007 |
Induction of mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical cancer cell.
Topics: Abrus; Agglutinins; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; DNA Fragmentation; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; HeLa Cells; Humans; Indicators and Reagents; Membrane Potentials; Mitochondria; Molecular Weight; Peptides; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Tumor Stem Cell Assay | 2008 |
Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa.
Topics: Acyl-Butyrolactones; Bacterial Outer Membrane Proteins; Bacterial Proteins; Catalase; Cytochromes c; Genetic Complementation Test; Glycolipids; Locomotion; Membrane Proteins; Mutagenesis, Insertional; Mutation; Oligopeptides; Phenols; Porphyrins; Pseudomonas aeruginosa; Pyocyanine; Quinolones; Thiazoles | 2008 |
Functional dynamic compartmentalization of respiratory chain intermediate substrates: implications for the control of energy production and mitochondrial diseases.
Topics: Animals; Cytochromes c; Electron Transport; Electron Transport Complex III; Electron Transport Complex IV; Male; Methacrylates; Mitochondria, Liver; Mitochondria, Muscle; Mitochondrial Diseases; Oxygen Consumption; Potassium Cyanide; Rats; Rats, Wistar; Thiazoles; Ubiquinone | 2008 |
The anticancer effect of protein-extract from Bidens alba in human colorectal carcinoma SW480 cells via the reactive oxidative species- and glutathione depletion-dependent apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bidens; Caspases; Cell Count; Cell Cycle; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cytochromes c; Cytosol; Flow Cytometry; Glutathione; Humans; In Situ Nick-End Labeling; Indicators and Reagents; Mitochondria; Plant Extracts; Plant Proteins; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2008 |
Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions.
Topics: Adenocarcinoma; Apoptosis; Aurora Kinase A; Aurora Kinases; Biomarkers, Tumor; Blotting, Western; Camptothecin; Coloring Agents; Cytochromes c; Enzyme Inhibitors; Esophageal Neoplasms; Flow Cytometry; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Luciferases; Luminescent Agents; Polymerase Chain Reaction; Protein Array Analysis; Protein Serine-Threonine Kinases; Stomach Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53 | 2008 |
Nephrotoxic cell death by diclofenac and meloxicam.
Topics: Animals; Annexin A5; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cell Survival; Coloring Agents; Cyclooxygenase Inhibitors; Cytochromes c; Diclofenac; Dogs; Fluorescein-5-isothiocyanate; Humans; Kidney Tubules; Meloxicam; Propidium; Staining and Labeling; Thiazines; Thiazoles | 2008 |
Berberine, a natural product, combined with cisplatin enhanced apoptosis through a mitochondria/caspase-mediated pathway in HeLa cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Caspases; Cisplatin; Cytochromes c; DNA Fragmentation; Drug Synergism; Enzyme Activation; HeLa Cells; Humans; Indicators and Reagents; Lipid Peroxidation; Membrane Potentials; Mitochondria; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2008 |
DNA damage response and apoptosis.
Topics: Annexin A5; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Caspase 3; Cell Fractionation; Cell Proliferation; Cell Survival; Cytochromes c; DNA Damage; DNA Fragmentation; Flow Cytometry; Histones; Humans; Immunohistochemistry; Tetrazolium Salts; Thiazoles | 2008 |
c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Cytochromes c; Dopamine; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra; Tetrazolium Salts; Thiazoles | 2008 |
Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors.
Topics: Anthracenes; Antimycin A; Binding Sites; Cell Line, Tumor; Cytochromes c; Electron Transport Complex III; Humans; Light; Methacrylates; Mitochondria; Mitochondrial Proton-Translocating ATPases; Models, Molecular; Perylene; Spectrophotometry, Ultraviolet; Submitochondrial Particles; Thiazoles; Ubiquinone | 2008 |
The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Apoptosis; Autoradiography; Benzoquinones; Caspase 3; Cell Line, Tumor; Copper; Cytochromes c; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; NAD; Neuroblastoma; Phenanthrolines; Phosphorus Isotopes; Salsoline Alkaloids; Tetrahydroisoquinolines; Tetrazolium Salts; Thiazoles; Time Factors; Tyrosine 3-Monooxygenase | 2009 |
Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain.
Topics: Acetylcysteine; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Calcium; Caspase 3; Caspase 8; Cell Division; Cytochromes c; Heterocyclic Compounds; Humans; MAP Kinase Kinase 4; Protein Kinase Inhibitors; Reactive Oxygen Species; Thiazoles; U937 Cells | 2009 |
Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis.
Topics: Annexin A5; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspases; Cell Death; Cell Proliferation; Cytochromes c; DNA Fragmentation; Flow Cytometry; HeLa Cells; Humans; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Saponins; Signal Transduction; Solanum; Tetrazolium Salts; Thiazoles | 2008 |
PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.
Topics: Analysis of Variance; Animals; Annexin A5; Antineoplastic Agents; bcl-2-Associated X Protein; Brain Neoplasms; Bromodeoxyuridine; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioma; Humans; Ligands; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Rats; Retinoid X Receptor gamma; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Transfection; Tretinoin; Tumor Stem Cell Assay | 2009 |
Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine.
Topics: Animals; Calcium Channels; Calcium Signaling; Cattle; Cell Death; Cells, Cultured; Chromaffin Cells; Clonazepam; Coloring Agents; Cytochromes c; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Patch-Clamp Techniques; Reactive Oxygen Species; Sodium Channels; Sodium-Calcium Exchanger; Tetrazolium Salts; Thiazepines; Thiazoles; Veratridine | 2009 |
Inhibition of mitochondria-dependent apoptosis by 635-nm irradiation in sodium nitroprusside-treated SH-SY5Y cells.
Topics: Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Humans; Light; Mitochondria; Neurons; Nitric Oxide; Nitroprusside; Peroxynitrous Acid; Superoxides; Tetrazolium Salts; Thiazoles | 2009 |
PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells.
Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Neoplasm Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Thiazoles; Tongue Neoplasms | 2009 |
Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Cell Death; Cell Line, Tumor; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria, Liver; Neuroblastoma; Reactive Oxygen Species; Recombinant Fusion Proteins; Tetrazolium Salts; Thiazoles | 2009 |
Cardioprotection leads to novel changes in the mitochondrial proteome.
Topics: Animals; Blotting, Western; Cardiotonic Agents; Cytochromes c; Electron Transport; Electrophoresis, Polyacrylamide Gel; Energy Metabolism; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Hemodynamics; Ischemic Preconditioning, Myocardial; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Myocardium; Necrosis; Proteome; Thiazoles; Urea | 2010 |
Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 2; Caspase Inhibitors; Comet Assay; Cytochromes c; DNA Damage; DNA Topoisomerases, Type II; Enzyme Inhibitors; Flow Cytometry; Glutathione; Goniothalamus; Humans; Jurkat Cells; Oligopeptides; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pyrones; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2010 |
Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids; Animals; Animals, Newborn; Astrocytes; Bridged Bicyclo Compounds, Heterocyclic; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Cytochromes c; DNA Fragmentation; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Gene Expression Regulation; In Situ Nick-End Labeling; Interferon-gamma; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Phosphatidylserines; Phosphodiesterase Inhibitors; Polyamines; Polysaccharides; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Tetrazolium Salts; Thiazoles | 2010 |
Cytochrome c is rapidly reduced in the cytosol after mitochondrial outer membrane permeabilization.
Topics: Anisomycin; Antifungal Agents; Antimycin A; Caspase 3; Caspase 9; Cytochromes c; Cytosol; Electron Transport; Enzyme Activation; HL-60 Cells; Humans; Methacrylates; Mitochondrial Membranes; Oxidation-Reduction; Oxygen; Oxygen Consumption; Permeability; Protein Synthesis Inhibitors; Rotenone; Spectrum Analysis; Thiazoles; Uncoupling Agents | 2010 |
Suppression of glutamate-induced excitotoxicity by 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride in rat glial cultures.
Topics: Animals; beta Catenin; Calcium; Cells, Cultured; Cytochromes c; Cytokines; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Inflammation Mediators; Membrane Potential, Mitochondrial; Neuroglia; Nitrites; Protective Agents; Protein Processing, Post-Translational; Rats; Rats, Wistar; Reactive Oxygen Species; Thiazoles | 2010 |
The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage.
Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Caspase 3; Catalase; Cell Line; Cell Survival; Coloring Agents; Cytochromes c; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Hydrogen Peroxide; Hydroxyquinolines; Insulin-Secreting Cells; Iron Chelating Agents; Membrane Potentials; Mitochondria; Monoamine Oxidase Inhibitors; Oxidants; Oxidative Stress; Piperazines; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles | 2010 |
Protective effects of galantamine against Abeta-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzimidazoles; Benzothiazoles; Blotting, Western; Calcium; Cell Survival; Coloring Agents; Congo Red; Cytochromes c; Endoplasmic Reticulum; Fluorescent Dyes; Galantamine; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Reactive Oxygen Species; Thiazoles | 2010 |
Antimycin A-induced mitochondrial apoptotic cascade is mitigated by phenolic constituents of Phyllanthus amarus aqueous extract in Hep3B cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Anti-Bacterial Agents; Antimycin A; Apoptosis; Apoptosis Inducing Factor; Bromodeoxyuridine; Cell Line; Coloring Agents; Cytochromes c; Deoxyguanosine; DNA, Mitochondrial; Flow Cytometry; Humans; In Vitro Techniques; Indicators and Reagents; Lipid Peroxidation; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Phenols; Phyllanthus; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles | 2010 |
Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway.
Topics: Amyloid beta-Peptides; Animals; Annexin A5; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation; Isoflavones; Neuroprotective Agents; Oncogene Protein v-akt; PC12 Cells; Peptide Fragments; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles | 2011 |
Effects of nicotine on apoptosis in human gingival fibroblasts.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Culture Techniques; Cell Nucleus; Cell Survival; Coloring Agents; Cytochromes c; DNA Fragmentation; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fluoresceins; Fluorescent Dyes; Gingiva; Humans; In Situ Nick-End Labeling; Indoles; JNK Mitogen-Activated Protein Kinases; Nicotine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors | 2011 |
Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells.
Topics: Antioxidants; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Cytochromes c; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug; Glutathione; Humans; Neuroblastoma; Tetrazolium Salts; Thiazoles; Time Factors; Trypan Blue; Ubiquinone | 2011 |
Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.
Topics: 14-3-3 Proteins; Animals; Apoptosis; Astrocytes; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cells, Cultured; Cytochromes c; Enzyme Activation; Hippocampus; Intracellular Space; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C-delta; Protein Multimerization; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Thiazoles | 2011 |
Effects of four types of hydroxyapatite nanoparticles with different nanocrystal morphologies and sizes on apoptosis in rat osteoblasts.
Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cell Proliferation; Cell Survival; Cells, Cultured; Coloring Agents; Crystallization; Cytochromes c; Dose-Response Relationship, Drug; Durapatite; Nanoparticles; Osteoblasts; Oxidative Stress; Particle Size; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53 | 2012 |
HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons.
Topics: Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 1; Cytochromes c; Dose-Response Relationship, Drug; Free Radical Scavengers; Gene Expression Regulation; Glutathione; Green Fluorescent Proteins; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Membrane Proteins; Metalloporphyrins; Neurons; Oxygen; Phenanthridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA Interference; Tetrazolium Salts; Thiazoles; Time Factors | 2012 |
Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: hirsutanol A inhibits tumor growth through ROS production.
Topics: Agaricales; Animals; Apoptosis; Cell Death; Cell Line, Tumor; Cytochromes c; Cytosol; Flow Cytometry; Humans; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasm Transplantation; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Tetrazolium Salts; Thiazoles | 2013 |
Detection and analysis of amorphous aggregates and fibrils of cytochrome c in the presence of phenolic acids.
Topics: Animals; Antioxidants; Benzothiazoles; Coumaric Acids; Cytochromes c; Fluorescent Dyes; Gallic Acid; Horses; Microscopy, Fluorescence; Multiprotein Complexes; Protein Multimerization; Protein Stability; Protein Structure, Quaternary; Protein Structure, Secondary; Proteostasis Deficiencies; Single-Cell Analysis; Thiazoles; Tryptophan | 2013 |
Synthesis of new quinolinequinone derivatives and preliminary exploration of their cytotoxic properties.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Coloring Agents; Cytochromes c; Drug Screening Assays, Antitumor; Electrochemistry; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Microwaves; Models, Molecular; NAD(P)H Dehydrogenase (Quinone); Oxygen Consumption; Quinolines; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles | 2013 |
Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Cell Line; Coloring Agents; Cytochromes c; Diosgenin; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; L-Lactate Dehydrogenase; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Myocardium; Myocytes, Cardiac; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2014 |
Cytotoxic, pro-apoptotic, pro-oxidant, and non-genotoxic activities of a novel copper(II) complex against human cervical cancer.
Topics: Animals; Annexins; Apoptosis; Brain Chemistry; Caspase 3; Caspase 7; Cell Line, Tumor; Coloring Agents; Coordination Complexes; Copper; Cytochromes c; Cytosol; DNA Fragmentation; Female; Flow Cytometry; Fluorescein-5-isothiocyanate; HeLa Cells; Humans; In Situ Nick-End Labeling; Lipid Peroxidation; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Oxidants; Phosphatidylserines; Rats; Salmonella typhimurium; Tetrazolium Salts; Thiazoles; Uterine Cervical Neoplasms | 2013 |
Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Biphenyl Compounds; Bisbenzimidazole; Breast Neoplasms; Caspases; Cell Division; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Cytochromes c; Female; Flow Cytometry; G2 Phase; Genes, bcl-2; Humans; Indicators and Reagents; Lignans; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2013 |
Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cytochromes c; DNA Primers; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Mice; Mitochondria; Nicotinamide N-Methyltransferase; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Tetrazolium Salts; Thiazoles | 2014 |
Deciphering aggregates, prefibrillar oligomers and protofibrils of cytochrome c.
Topics: Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Cytochromes c; DNA Damage; Humans; Microscopy, Electron, Scanning; Neurodegenerative Diseases; Polyethylene Glycols; Protein Aggregates; Protein Conformation; Protein Folding; Proteostasis Deficiencies; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Thiazoles; Trifluoroethanol | 2014 |
The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Autophagy; BH3 Interacting Domain Death Agonist Protein; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cytochromes c; Humans; Indoles; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Mitochondria; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Tetrazolium Salts; Thiazoles; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Wasabia; Xenograft Model Antitumor Assays | 2016 |
Functional characterization of a soluble NADPH-cytochrome P450 reductase from Fusarium graminearum.
Topics: Cloning, Molecular; Cytochromes c; Enzyme Assays; Escherichia coli; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Fungal Proteins; Fusarium; Gene Expression; Genetic Vectors; Histidine; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Oligopeptides; Oxidation-Reduction; Recombinant Fusion Proteins; Substrate Specificity; Temperature; Tetrazolium Salts; Thiazoles; Trichothecenes | 2017 |
Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway.
Topics: Antineoplastic Agents; Apoptosis; Bicyclic Monoterpenes; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Drug Design; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; Humans; Membrane Potential, Mitochondrial; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Thiazoles | 2019 |
Synthetic antiprotozoal thiazolide drug induced apoptosis in colorectal cancer cells: implications of IL-6/JAK2/STAT3 and p53/caspases-dependent signaling pathways based on molecular docking and in vitro study.
Topics: Antineoplastic Agents; Antiprotozoal Agents; Apoptosis; Caspases; Cell Cycle; Cell Survival; Colorectal Neoplasms; Cytochromes c; Fluorouracil; HCT116 Cells; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Interleukin-6; Janus Kinase 2; Molecular Docking Simulation; Nitro Compounds; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; STAT3 Transcription Factor; Thiazoles; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2020 |