thiazoles has been researched along with curacin a in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 13 (44.83) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blokhin, AV; Geralds, RS; Gerwick, WH; Hamel, E; Nagle, DG; Yoo, HD | 1 |
| Day, BW; Falck, JR; Gerwick, WH; Hamel, E; Lai, JY; Marquez, B; Nagle, DG; Nambu, M; Verdier-Pinard, P; White, JD; Yoo, HD; Yu, J | 1 |
| Berman, FW; Gerwick, WH; Murray, TF | 1 |
| Gerwick, WH; Hamel, E; Rossi, JV; Sackett, DL; Sitachitta, N; Verdier-Pinard, P | 1 |
| Iwasaki, S; Shirai, R | 1 |
| Chen, P; Day, BW; Grant, SG; Kozusko, F; Panetta, JC | 1 |
| Balachandran, R; Day, BW; Reeves, JT; Wipf, P | 1 |
| Giuliano, KA | 1 |
| Day, BW; Reeves, JT; Wipf, P | 1 |
| Chang, Z; Flatt, PM; Gerwick, WH; Jia, J; Roberts, MA; Rossi, JV; Sherman, DH; Sitachitta, N | 1 |
| Burnett, JC; Day, BW; Gussio, R; Hamel, E; Hermone, AR; McGrath, C; Nguyen, TL; Wipf, P; Zaharevitz, DW | 1 |
| Gerwick, WH; Gu, L; Håkansson, K; Jia, J; Liu, H; Sherman, DH | 1 |
| Geders, TW; Gerwick, WH; Gu, L; Håkansson, K; Liu, H; Mowers, JC; Sherman, DH; Smith, JL | 1 |
| Geders, TW; Gerwick, WH; Gu, L; Håkansson, K; Sherman, DH; Smith, JL; Wang, B | 1 |
| Geders, TW; Gerwick, L; Gerwick, WH; Grindberg, RV; Gu, L; Håkansson, K; Kulkarni, A; Sherman, DH; Smith, JL; Wang, B; Wipf, P | 1 |
| Gehret, JJ; Gerwick, L; Gerwick, WH; Gu, L; Håkansson, K; Kulkarni, A; Lloyd, KR; Sherman, DH; Smith, JL; Wang, B; Wipf, P | 1 |
| Akey, DL; Gerwick, WH; Razelun, JR; Sherman, DH; Smith, JL; Tehranisa, J | 1 |
| Gerwick, WH; Gu, L; Håkansson, K; Khare, D; Razelun, J; Sherman, DH; Smith, JL; Wang, B | 1 |
| Gehret, JJ; Gerwick, WH; Gu, L; Sherman, DH; Smith, JL; Wipf, P | 1 |
| Dutta, S; Eisman, EB; Franzmann, TM; Gerwick, WH; Gu, L; Sherman, DH; Skiniotis, G; Walter, S | 1 |
| Allen, EE; Burkart, MD; Dorrestein, PC; Esquenazi, E; Gerwick, L; Gerwick, WH; Hess, WR; Hoover, H; Jones, AC; Klages, S; Kube, M; Lasken, RS; Monroe, EA; Niessen, S; Podell, S; Reinhardt, R; Rothmann, M; Yates, JR | 1 |
| Busche, A; Dötsch, V; Eisman, EB; Gottstein, D; Gu, L; Güntert, P; Hein, C; Löhr, F; Pader, I; Ripin, N; Sherman, DH; Tufar, P; Walsh, CT | 1 |
| Akey, DL; Gehret, JJ; Khare, D; Smith, JL | 1 |
| Gerwick, WH; Gu, L; Håkansson, K; Hale, WA; Khare, D; Sherman, DH; Smith, JL; Tripathi, A | 1 |
| Bi, S; Li, X; Ling, B; Liu, Y; Wang, Z | 1 |
| Gerwick, L; Gerwick, WH; Maloney, FP; Sherman, DH; Smith, JL | 1 |
| Hitora, Y; Ito, A; Matsunaga, S; Okada, S; Takada, K; Ueoka, R; Yoshida, M | 1 |
| Aldrich, CC; Fiers, WD; Gerwick, WH; Sherman, DH; Sikkema, AP; Skiba, MA; Smith, JL | 1 |
| Aldrich, CC; Dodge, GJ; Fiers, WD; Sherman, DH; Smith, JL | 1 |
3 review(s) available for thiazoles and curacin a
| Article | Year |
|---|---|
[Natural organic compounds that affect to microtubule functions: syntheses and structure-activity relationships of combretastatins, curacin A and their analogs as the colchicine-site ligands on tubulin].
Topics: Bibenzyls; Binding Sites; Cell Cycle; Colchicine; Cyclopropanes; Ligands; Microtubules; Protein Binding; Stilbenes; Structure-Activity Relationship; Thiazoles; Tubulin | 2000 |
Chemistry and biology of curacin A.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cyclopropanes; Humans; Structure-Activity Relationship; Thiazoles; Tubulin | 2004 |
Insights from the sea: structural biology of marine polyketide synthases.
Topics: Biological Products; Cyclopropanes; Marine Biology; Molecular Structure; Polyketide Synthases; Polyketides; Protein Conformation; Thiazoles | 2012 |
26 other study(ies) available for thiazoles and curacin a
| Article | Year |
|---|---|
Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues.
Topics: Animals; Antineoplastic Agents; Binding Sites; Binding, Competitive; Cattle; Colchicine; Cyanobacteria; Cyclopropanes; Kinetics; Structure-Activity Relationship; Thiazoles; Tubulin | 1995 |
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.
Topics: Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cattle; Cell Division; Colchicine; Cyclopropanes; DNA, Neoplasm; Drug Interactions; G2 Phase; Humans; Mitosis; Models, Chemical; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured | 1998 |
Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cerebellum; Cyanobacteria; Cyclopropanes; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Lethal Dose 50; Lipids; Lipopeptides; Lipoproteins; Marine Toxins; Neurons; Neuroprotective Agents; Neurotoxins; Peptides, Cyclic; Rats; Receptors, N-Methyl-D-Aspartate; Thiazoles | 1999 |
Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.
Topics: Antineoplastic Agents; Binding Sites; Carbon Radioisotopes; Colchicine; Cyanobacteria; Cyclopropanes; Isotope Labeling; Kinetics; Molecular Structure; Thiazoles; Tubulin | 1999 |
A mathematical model of in vitro cancer cell growth and treatment with the antimitotic agent curacin A.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Cyclopropanes; Female; Flow Cytometry; Humans; Inhibitory Concentration 50; Kinetics; Mitosis; Models, Biological; Ovarian Neoplasms; Thiazoles; Tumor Cells, Cultured | 2001 |
Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.
Topics: Antineoplastic Agents; Biopolymers; Blood Proteins; Cell Division; Cyclopropanes; Drug Screening Assays, Antitumor; Humans; Oximes; Protein Binding; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes; Tubulin; Tumor Cells, Cultured | 2002 |
High-content profiling of drug-drug interactions: cellular targets involved in the modulation of microtubule drug action by the antifungal ketoconazole.
Topics: Animals; Antifungal Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Size; Cyclopropanes; Drug Interactions; Humans; Ketoconazole; Microtubules; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Thiazoles; Vinblastine | 2003 |
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.
Topics: Amino Acid Sequence; Antineoplastic Agents; Cyanobacteria; Cyclopropanes; Marine Toxins; Mitosis; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Sequence Alignment; Thiazoles; Tubulin Modulators | 2004 |
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.
Topics: 2-Methoxyestradiol; 4-Butyrolactone; Aminophenols; Binding Sites; Chalcone; Colchicine; Cyclopropanes; Estradiol; Indans; Lignans; Models, Molecular; Molecular Structure; Nocodazole; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tubulin; Tubulin Modulators | 2005 |
Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair.
Topics: Bacterial Proteins; Cyanobacteria; Cyclopropanes; Enzymes; Molecular Structure; Thiazoles | 2006 |
Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.
Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Carboxy-Lyases; Catalytic Domain; Crystallography, X-Ray; Cyanobacteria; Cyclopropanes; Enoyl-CoA Hydratase; Macrolides; Mutagenesis, Site-Directed; Mutation, Missense; Substrate Specificity; Thiazoles | 2007 |
GNAT-like strategy for polyketide chain initiation.
Topics: Acetyl Coenzyme A; Acetyltransferases; Acyl Carrier Protein; Amino Acid Sequence; Carboxy-Lyases; Crystallography, X-Ray; Cyanobacteria; Cyclopropanes; Decarboxylation; Malonyl Coenzyme A; Models, Molecular; Molecular Sequence Data; Polyketide Synthases; Protein Conformation; Protein Structure, Tertiary; Thiazoles | 2007 |
Metamorphic enzyme assembly in polyketide diversification.
Topics: Cyanobacteria; Cyclopropanes; Enzymes; Evolution, Molecular; Halogenation; Thiazoles; Vinyl Chloride | 2009 |
Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.
Topics: Antineoplastic Agents; Bacterial Proteins; Cyanobacteria; Cyclopropanes; Decarboxylation; Macrolides; Metabolic Networks and Pathways; Polyketide Synthases; Sulfones; Sulfotransferases; Thiazoles; Tubulin Modulators | 2009 |
Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.
Topics: Amino Acid Sequence; Biocatalysis; Crystallography, X-Ray; Cyclopropanes; Hydro-Lyases; Models, Molecular; Molecular Sequence Data; Polyketide Synthases; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity; Thiazoles | 2010 |
Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.
Topics: Crystallography, X-Ray; Cyclopropanes; Halogenation; Iron; Ketoglutaric Acids; Mutagenesis, Site-Directed; Oxidoreductases; Protein Binding; Protein Conformation; Substrate Specificity; Thiazoles | 2010 |
Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase.
Topics: Amino Acid Sequence; Biofuels; Carboxylic Acids; Crystallography, X-Ray; Cyanobacteria; Cyclopropanes; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitoyl-CoA Hydrolase; Polyketide Synthases; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Sequence Homology, Amino Acid; Thiazoles | 2011 |
Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.
Topics: Acyl Carrier Protein; Biosynthetic Pathways; Cyclopropanes; Multienzyme Complexes; Multigene Family; Polyketide Synthases; Thiazoles | 2011 |
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.
Topics: Cyanobacteria; Cyclopropanes; Ecology; Gene Regulatory Networks; Genes, Bacterial; Genome, Bacterial; Marine Biology; Nitrogen Fixation; Sequence Analysis, DNA; Thiazoles | 2011 |
Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase.
Topics: Acyl Carrier Protein; Bacterial Proteins; Cyanobacteria; Cyclopropanes; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Polyketide Synthases; Protein Structure, Tertiary; Thiazoles | 2012 |
Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase.
Topics: Amino Acid Sequence; Bacterial Proteins; Cyclopropanes; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Molecular Sequence Data; Thiazoles | 2015 |
Identification of the active site of human mitochondrial malonyl-coenzyme a decarboxylase: A combined computational study.
Topics: Acetyl Coenzyme A; Carboxy-Lyases; Catalytic Domain; Cyclopropanes; Humans; Malonyl Coenzyme A; Mitochondria; Molecular Docking Simulation; Molecular Dynamics Simulation; Thermodynamics; Thiazoles | 2016 |
Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Topics: Acyl Carrier Protein; Acyl Coenzyme A; Amino Acid Sequence; Catalytic Domain; Crystallography, X-Ray; Cyclopropanes; Hydroxymethylglutaryl-CoA Synthase; Polyketide Synthases; Polyketides; Streptomyces; Substrate Specificity; Thiazoles | 2016 |
Curacin E from the Brittle Star Ophiocoma scolopendrina.
Topics: Animals; Antineoplastic Agents; Cyanobacteria; Cyclopropanes; Echinodermata; Mitosis; Molecular Structure; Thiazoles; Tubulin | 2016 |
Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.
Topics: Catalytic Domain; Crystallography, X-Ray; Cyanobacteria; Cyclopropanes; Methyltransferases; Models, Molecular; Polyketide Synthases; Protein Conformation; Thiazoles | 2016 |
Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.
Topics: Alcohol Oxidoreductases; Bacterial Proteins; Cyanobacteria; Cyclopropanes; Dehydration; Molecular Conformation; Protein Domains; Thiazoles | 2016 |