thiazoles has been researched along with colchicine in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (14.55) | 18.2507 |
| 2000's | 18 (32.73) | 29.6817 |
| 2010's | 28 (50.91) | 24.3611 |
| 2020's | 1 (1.82) | 2.80 |
| Authors | Studies |
|---|---|
| Griswold, DE; Hillegass, LM; Webb, EF | 1 |
| de Médicis, R; Gilbert, C; Grimard, M; Lussier, A; Naccache, PH; Poubelle, PE; Roberge, CJ | 1 |
| Canning, PC; Kehrli, ME; Stevens, MG | 1 |
| Blokhin, AV; Geralds, RS; Gerwick, WH; Hamel, E; Nagle, DG; Yoo, HD | 1 |
| Adler, ID; Beisker, W; Cao, J; Nüsse, M | 1 |
| Day, BW; Falck, JR; Gerwick, WH; Hamel, E; Lai, JY; Marquez, B; Nagle, DG; Nambu, M; Verdier-Pinard, P; White, JD; Yoo, HD; Yu, J | 1 |
| Gerke, V; Kielbassa, K; Schmitz, C | 1 |
| Gerwick, WH; Hamel, E; Rossi, JV; Sackett, DL; Sitachitta, N; Verdier-Pinard, P | 1 |
| Radmacher, M; Rotsch, C | 1 |
| Iwasaki, S; Shirai, R | 1 |
| Bienz, M; Townsley, FM | 1 |
| Norvell, SM; Pavalko, FM; Ponik, SM; Sawyer, SJ | 1 |
| Eggli, P; Keller, H; Zadeh, AD | 1 |
| Cantillana, V; Fernández, J; Ubilla, A | 1 |
| Giordano, ME; Hoffmann, EK; Lionetto, MG; Pedersen, SF; Schettino, T | 1 |
| Giehl, K; Goppelt-Struebe, M; Graness, A; Iwanciw, D; Ott, C | 1 |
| Gurhan, I; Hasirci, N; Muvaffak, A | 1 |
| George, T; Good, DW; Watts, BA | 1 |
| Laporte, SA; Laroche, G; Parent, JL; Rochdi, MD | 1 |
| Desai, JC; Leach, RN; Orchard, CH | 1 |
| Burnett, JC; Day, BW; Gussio, R; Hamel, E; Hermone, AR; McGrath, C; Nguyen, TL; Wipf, P; Zaharevitz, DW | 1 |
| Choy, G | 1 |
| Geist, MA; Johansen, FF; Leist, M; Müller, GJ; Vaudano, E; Veng, LM; Willesen, MG | 1 |
| Bär, T; Beckers, TL; Eichhorn, E; Höcher, H; Mahboobi, S; Maier, T; Schmidt, M; Sellmer, A; Stadlwieser, JF | 1 |
| Abeles, AM; Pillinger, MH; Rosenthal, P | 1 |
| Lioté, F; Perez-Ruiz, F; Scavulli, J; Terkeltaub, R; Zelman, D | 1 |
| Sundy, JS | 1 |
| Schlesinger, N | 1 |
| Ahn, S; Dalton, JT; Li, CM; Lu, Y; Miller, DD; Narayanan, R | 1 |
| Chang, CM; Chao, YS; Chen, CP; Chen, CT; Chen, TW; Chuu, JJ; Hsu, TA; Huang, CL; Hwang, DR; Li, WT; Lien, TW; Lin, CC; Lin, CH; Lin, HL; Song, JS; Tseng, HY | 1 |
| Quillen, DM | 1 |
| Graser, E; Pope, RS; Zychowicz, ME | 1 |
| El-Zawawy, H; Mandell, BF | 1 |
| Cohen, MG | 1 |
| Dubost, JJ; Mathieu, S; Soubrier, M | 1 |
| Doghramji, PP | 1 |
| Baraldi, PG; Basso, G; Bortolozzi, R; Brancale, A; Hamel, E; Ricci, A; Romagnoli, R; Viola, G | 1 |
| Ahn, S; Chen, J; Dalton, JT; Li, CM; Li, W; Lu, Y; Miller, DD; Narayanan, R; Parke, DN | 1 |
| Das, P; Suresh, E | 1 |
| Andreani, A; Calonghi, N; Cappadone, C; Farruggia, G; Granaiola, M; Hamel, E; Locatelli, A; Masotti, L; Morigi, R; Nguyen, TL; Rambaldi, M; Shoemaker, RH; Stefanelli, C; Varoli, L | 1 |
| Curiel, RV; Guzman, NJ | 1 |
| Doghramji, PP; Mandell, BF; Pope, RS | 1 |
| Covell, DG | 1 |
| Baraldi, PG; Bassetto, M; Basso, G; Bortolozzi, R; Brancale, A; Camacho, ME; Hamel, E; Preti, D; Romagnoli, R; Salvador, MK; Tabrizi, MA; Viola, G | 1 |
| Bianchi, G; Borghi, C; Bortoluzzi, A; Cimmino, MA; D'Avola, GM; Desideri, G; Di Giacinto, G; Favero, M; Govoni, M; Grassi, W; Lombardi, A; Manara, M; Marangella, M; Matucci Cerinic, M; Medea, G; Minisola, G; Prevete, I; Punzi, L; Ramonda, R; Scirè, CA; Spadaro, A | 1 |
| Franklin, JM; Kim, SC; Liu, J; Schmidt, BM; Schneeweiss, S; Solomon, DH | 1 |
| Cassimeris, L; Kumar, R; Louis, XL; Rajasekharan, KN; Sengupta, S; Sivakumar, KC; Sreedevi, KJ; Thamkachy, R; Thomas, NE; Thomas, SA | 1 |
| Stamp, LK | 1 |
| Baumgartner, S; Fleischmann, R; Hingorani, V; Kerr, B; Manhard, K; Miner, JN; Polvent, E; Quart, B; Shen, Z; Suster, M; Yeh, LT | 1 |
| Mounsey, A; Tillett, J; White, S | 1 |
| Bombardier, C; Buchbinder, R; Edwards, CJ; Kydd, AS; Seth, R | 1 |
| Dalbeth, N; Robinson, PC | 1 |
| Chen, L; He, L; Liu, Y; Ma, L; Nie, C; Pu, Y; Shao, M; Wang, F; Wu, W; Wu, Y; Yang, Z; Yu, K | 1 |
| Aggrawal, A; Kumar, A; Pottabathini, R; Singh, A | 1 |
| Guan, Q; Hong, Y; Li, B; Li, M; Li, N; Li, X; Wu, L; Zhang, B; Zhang, W | 1 |
15 review(s) available for thiazoles and colchicine
| Article | Year |
|---|---|
[Natural organic compounds that affect to microtubule functions: syntheses and structure-activity relationships of combretastatins, curacin A and their analogs as the colchicine-site ligands on tubulin].
Topics: Bibenzyls; Binding Sites; Cell Cycle; Colchicine; Cyclopropanes; Ligands; Microtubules; Protein Binding; Stilbenes; Structure-Activity Relationship; Thiazoles; Tubulin | 2000 |
An update on the treatment options for gout and calcium pyrophosphate deposition.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chondrocalcinosis; Colchicine; Drug Combinations; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Multicenter Studies as Topic; Probenecid; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2005 |
Hyperuricemia and gout: new insights into pathogenesis and treatment.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Interleukin 1 Receptor Antagonist Protein; Thiazoles; Urate Oxidase; Uric Acid | 2007 |
Progress in the pharmacotherapy of gout.
Topics: Allopurinol; Clinical Trials as Topic; Colchicine; Drug Therapy, Combination; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Recombinant Fusion Proteins; Thiazoles; Uricosuric Agents | 2010 |
New agents for the treatment of gout and hyperuricemia: febuxostat, puricase, and beyond.
Topics: Acute Disease; Chronic Disease; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Polyethylene Glycols; Thiazoles; Urate Oxidase | 2010 |
Crystal arthropathies: recognizing and treating "the gouch".
Topics: Allopurinol; Antimetabolites; Chronic Disease; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thiazoles; Uric Acid; Uricosuric Agents | 2010 |
Managing gout: how is it different in patients with chronic kidney disease?
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Comorbidity; Disease Progression; Febuxostat; Gout; Gout Suppressants; Humans; Kidney Failure, Chronic; Risk Factors; Thiazoles | 2010 |
[Treatment of gout].
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Thiazoles; Uric Acid; Uricosuric Agents | 2011 |
Managing your patient with gout: a review of treatment options.
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Diet; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Life Style; Patient Education as Topic; Quality of Life; Risk Factors; Thiazoles | 2011 |
Recent advances in management of gout.
Topics: Adrenal Cortex Hormones; Alcohol Drinking; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Ascorbic Acid; Colchicine; Comorbidity; Cryotherapy; Diet; Dose-Response Relationship, Drug; Febuxostat; Fructose; Gout; Gout Suppressants; Humans; Interleukin 1 Receptor Antagonist Protein; Polyethylene Glycols; Purines; Receptors, Interleukin-1; Recombinant Fusion Proteins; Thiazoles; Urate Oxidase; Uric Acid; Uricosuric Agents; Vitamins; Xanthine Oxidase | 2012 |
Challenges associated with the management of gouty arthritis in patients with chronic kidney disease: a systematic review.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Comorbidity; Contraindications; Febuxostat; Glucocorticoids; Gout Suppressants; Humans; Hyperuricemia; Polyethylene Glycols; Probenecid; PubMed; Renal Insufficiency, Chronic; Secondary Prevention; Thiazoles; Urate Oxidase | 2012 |
Safety profile of anti-gout agents: an update.
Topics: Allopurinol; Colchicine; Drug Interactions; Febuxostat; Gout; Gout Suppressants; HLA-B Antigens; Humans; Interleukin-1; Polyethylene Glycols; Risk Factors; Safety; Thiazoles; Urate Oxidase | 2014 |
Clinical inquiry: Which prophylactic therapies best prevent gout attacks?
Topics: Allopurinol; Colchicine; Evidence-Based Medicine; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Quality of Life; Thiazoles; Urate Oxidase | 2014 |
Allopurinol for chronic gout.
Topics: Allopurinol; Benzbromarone; Chronic Disease; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Probenecid; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid | 2014 |
Advances in pharmacotherapy for the treatment of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzbromarone; Clinical Trials, Phase III as Topic; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Probenecid; Thiazoles; Urate Oxidase; Uric Acid | 2015 |
1 trial(s) available for thiazoles and colchicine
| Article | Year |
|---|---|
Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.
Topics: Adult; Aged; Colchicine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Thioglycolates; Triazoles; Uric Acid | 2014 |
39 other study(ies) available for thiazoles and colchicine
| Article | Year |
|---|---|
Induction of plasma exudation and inflammatory cell infiltration by leukotriene C4 and leukotriene B4 in mouse peritonitis.
Topics: Animals; Ascites; Capillary Permeability; Chemotaxis, Leukocyte; Colchicine; Drug Interactions; Imidazoles; Inflammation; Injections, Intraperitoneal; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Neutrophils; Peritonitis; Pyrazoles; SRS-A; Thiazoles | 1991 |
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
Topics: Alkaloids; Calcium; Calcium Pyrophosphate; Carbazoles; Cholera Toxin; Colchicine; Crystallization; Cytochalasin B; Cytoplasm; Diacylglycerol Kinase; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indole Alkaloids; Neutrophils; Oxidation-Reduction; Pertussis Toxin; Phosphotransferases; Protein Kinase C; Pyrimidinones; Staurosporine; Superoxides; Thiazoles; Uric Acid; Virulence Factors, Bordetella | 1991 |
A colorimetric assay for quantitating bovine neutrophil bactericidal activity.
Topics: Analysis of Variance; Animals; Cattle; Cattle Diseases; Colchicine; Colony Count, Microbial; Colorimetry; Cytochalasin B; Interferon-gamma; Neutrophils; Recombinant Proteins; Serum Bactericidal Test; Staphylococcus aureus; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Thiazoles | 1991 |
Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues.
Topics: Animals; Antineoplastic Agents; Binding Sites; Binding, Competitive; Cattle; Colchicine; Cyanobacteria; Cyclopropanes; Kinetics; Structure-Activity Relationship; Thiazoles; Tubulin | 1995 |
Flow cytometric detection of micronuclei induced by chemicals in poly- and normochromatic erythrocytes of mouse peripheral blood.
Topics: Acrylamide; Acrylamides; Animals; Benzimidazoles; Benzothiazoles; Bone Marrow; Colchicine; Erythrocytes; Flow Cytometry; Fluorescent Dyes; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Microscopy, Fluorescence; Mitomycin; Quinolines; Thiazoles | 1993 |
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.
Topics: Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cattle; Cell Division; Colchicine; Cyclopropanes; DNA, Neoplasm; Drug Interactions; G2 Phase; Humans; Mitosis; Models, Chemical; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured | 1998 |
Disruption of endothelial microfilaments selectively reduces the transendothelial migration of monocytes.
Topics: Actin Cytoskeleton; Bridged Bicyclo Compounds, Heterocyclic; Cell Movement; Cells, Cultured; Coculture Techniques; Colchicine; Culture Media, Conditioned; Cytochalasin B; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Microscopy, Fluorescence; Monocytes; Nocodazole; Paclitaxel; Protein Kinase C; Sulfonamides; Thiazoles; Thiazolidines; Trifluoperazine; Tumor Necrosis Factor-alpha | 1998 |
Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.
Topics: Antineoplastic Agents; Binding Sites; Carbon Radioisotopes; Colchicine; Cyanobacteria; Cyclopropanes; Isotope Labeling; Kinetics; Molecular Structure; Thiazoles; Tubulin | 1999 |
Drug-induced changes of cytoskeletal structure and mechanics in fibroblasts: an atomic force microscopy study.
Topics: 3T3 Cells; Actins; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Colchicine; Cytochalasin B; Cytochalasin D; Cytoskeleton; Demecolcine; Depsipeptides; Elasticity; Fibroblasts; Kinetics; Marine Toxins; Mice; Microscopy, Atomic Force; Microscopy, Fluorescence; Microtubules; Paclitaxel; Peptides, Cyclic; Rats; Stress, Mechanical; Thiazoles; Thiazolidines | 2000 |
Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo.
Topics: Actin Cytoskeleton; Actins; Adenomatous Polyposis Coli Protein; Adherens Junctions; Animals; Armadillo Domain Proteins; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cell Size; Colchicine; Contractile Proteins; Cytochalasin D; Cytoskeletal Proteins; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Female; Fluorescent Dyes; Insect Proteins; Microfilament Proteins; Microscopy, Confocal; Microtubules; Ovary; Phalloidine; Profilins; Thiazoles; Thiazolidines; Trans-Activators; Transcription Factors | 2000 |
Regulation of PGE(2) and PGI(2) release from human umbilical vein endothelial cells by actin cytoskeleton.
Topics: Actins; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Cells, Cultured; Colchicine; Cytochalasin D; Cytoskeleton; Dinoprostone; Endothelium, Vascular; Epoprostenol; Humans; Kinetics; Marine Toxins; Microtubules; Nocodazole; Thiazoles; Thiazolidines; Umbilical Veins | 2001 |
Localised depletion of polymerised actin at the front of Walker carcinosarcoma cells increases the speed of locomotion.
Topics: Actinin; Actins; Amides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma 256, Walker; Cell Membrane; Cell Movement; Cell Polarity; Cell Size; Cell Surface Extensions; Colchicine; Diacetyl; Enzyme Inhibitors; Humans; Myosins; Pyridines; Thiazoles; Thiazolidines | 2002 |
Reorganization and translocation of the ectoplasmic cytoskeleton in the leech zygote by condensation of cytasters and interactions of dynamic microtubules and actin filaments.
Topics: Actin Cytoskeleton; Animals; Bridged Bicyclo Compounds, Heterocyclic; Colchicine; Cytoskeleton; Fluorescent Dyes; Interphase; Leeches; Microinjections; Microscopy, Video; Microtubules; Paclitaxel; Phalloidine; Protein Transport; Thiazoles; Thiazolidines; Time Factors; Zygote | 2002 |
Roles of the cytoskeleton and of protein phosphorylation events in the osmotic stress response in eel intestinal epithelium.
Topics: Actins; Alkaloids; Anguilla; Animals; Azepines; Benzophenanthridines; Bridged Bicyclo Compounds, Heterocyclic; Bumetanide; Cell Size; Colchicine; Cytochalasins; Cytoskeleton; Enzyme Inhibitors; Hypertonic Solutions; Hypotonic Solutions; Intestinal Mucosa; Ion Transport; Isoquinolines; Marine Toxins; Microtubules; Naphthalenes; Osmotic Pressure; Oxazoles; Phenanthridines; Phosphorylation; Protein Serine-Threonine Kinases; Sulfonamides; Thiazoles; Thiazolidines | 2002 |
Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton.
Topics: Actins; Amides; Bacterial Proteins; Bacterial Toxins; Botulinum Toxins; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Colchicine; Connective Tissue Growth Factor; Cytochalasin D; Cytoskeleton; Fibroblasts; Gene Expression Regulation; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Nocodazole; Paclitaxel; Pyridines; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Stress, Mechanical; Thiazoles; Thiazolidines | 2003 |
Prolonged cytotoxic effect of colchicine released from biodegradable microspheres.
Topics: Biocompatible Materials; Biodegradation, Environmental; Cell Line; Cell Survival; Colchicine; Dosage Forms; Excipients; Gelatin; HeLa Cells; Humans; Microspheres; Particle Size; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Tetrazolium Salts; Thiazoles | 2004 |
The basolateral NHE1 Na+/H+ exchanger regulates transepithelial HCO3- absorption through actin cytoskeleton remodeling in renal thick ascending limb.
Topics: Absorption; Actins; Amiloride; Animals; Bicarbonates; Bridged Bicyclo Compounds, Heterocyclic; Colchicine; Depsipeptides; Epithelium; Loop of Henle; Male; Nerve Growth Factor; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Solubility; Thiazoles; Thiazolidines | 2005 |
Involvement of actin in agonist-induced endocytosis of the G protein-coupled receptor for thromboxane A2: overcoming of actin disruption by arrestin-3 but not arrestin-2.
Topics: Actins; Antineoplastic Agents; Arrestins; Bridged Bicyclo Compounds, Heterocyclic; cdc42 GTP-Binding Protein; Cell Line; Clathrin; Cloning, Molecular; Colchicine; Cytochalasin D; Cytoskeleton; Depsipeptides; Endocytosis; Enzyme-Linked Immunosorbent Assay; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Marine Toxins; Microscopy, Fluorescence; Nucleic Acid Synthesis Inhibitors; Phosphoproteins; Plasmids; Protein Binding; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Receptors, Thromboxane A2, Prostaglandin H2; rhoA GTP-Binding Protein; Signal Transduction; Thiazoles; Thiazolidines; Time Factors; Transfection | 2005 |
Effect of cytoskeleton disruptors on L-type Ca channel distribution in rat ventricular myocytes.
Topics: Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels, L-Type; Cells, Cultured; Colchicine; Cycloheximide; Cytochalasin D; Cytoskeletal Proteins; Heart Ventricles; Immunohistochemistry; Male; Microtubules; Myocytes, Cardiac; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Tubulin | 2005 |
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.
Topics: 2-Methoxyestradiol; 4-Butyrolactone; Aminophenols; Binding Sites; Chalcone; Colchicine; Cyclopropanes; Estradiol; Indans; Lignans; Models, Molecular; Molecular Structure; Nocodazole; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tubulin; Tubulin Modulators | 2005 |
A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Carbazoles; Caspase 3; Caspases; Cell Count; Cells, Cultured; Cerebellum; Colchicine; Cytoskeleton; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Immunohistochemistry; Indoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred BALB C; Neurons; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Signal Transduction; Tetrazolium Salts; Thiazoles | 2006 |
[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines.
Topics: Aniline Compounds; Binding Sites; Cell Line, Tumor; Cell Shape; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship; Thiazoles; Tubulin; Tubulin Modulators | 2006 |
Gout Study Group: update on hyperuricemia and gout.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diet; Europe; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Life Style; Prednisone; Prevalence; Thiazoles; United States; Uric Acid | 2009 |
Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin.
Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Chromatography, Liquid; Colchicine; Docetaxel; Guanosine Triphosphate; Linear Models; Paclitaxel; Podophyllotoxin; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Taxoids; Thiazoles; Tubulin; Tubulin Modulators; Vinblastine; Vincristine | 2010 |
Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Humans; Imidazoles; Inhibitory Concentration 50; Male; Mice; Mice, Inbred DBA; Mice, Nude; Microtubules; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Thiazoles; Time Factors; Tubulin; Tubulin Modulators | 2012 |
The current state of care in gout: Addressing the need for better understanding of an ancient disease.
Topics: Acute Disease; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Arthritis, Rheumatoid; Chronic Disease; Colchicine; Comorbidity; Disease Progression; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Patient Education as Topic; Quality of Life; Risk Factors; Thiazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2010 |
Treatment of gout.
Topics: Aged; Allopurinol; Australia; Colchicine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Febuxostat; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Patient Compliance; Practice Guidelines as Topic; Prednisolone; Renal Dialysis; Thiazoles; Uric Acid | 2011 |
Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspase Inhibitors; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Microtubules; Mitosis; Models, Molecular; Protein Binding; Structure-Activity Relationship; Thiazoles; Tubulin Modulators | 2011 |
Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability.
Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Line, Tumor; Colchicine; Dogs; Female; Humans; Imidazoles; Male; Mice; Microsomes, Liver; Microtubules; Paclitaxel; Rats; Solubility; Structure-Activity Relationship; Thiazoles; Tubulin; Tubulin Modulators; Vinblastine | 2011 |
Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Screening Assays, Antitumor; Enzyme Activation; G2 Phase; Humans; Imidazoles; Indoles; Mitogen-Activated Protein Kinases; Models, Molecular; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-akt; Signal Transduction; Structure-Activity Relationship; Thiazoles; Tubulin; Tubulin Modulators | 2012 |
Casebook consults: improving outcomes in gout (multimedia activity).
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Long-Term Care; Medication Adherence; Referral and Consultation; Thiazoles; Uric Acid | 2012 |
Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen.
Topics: Algorithms; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cluster Analysis; Colchicine; Computational Biology; Cyclin-Dependent Kinases; Dasatinib; Databases, Genetic; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Neoplasms; Oligonucleotide Array Sequence Analysis; Paclitaxel; Pimozide; Purines; Pyrimidines; Terfenadine; Thiazoles; Tubulin Modulators; Verapamil | 2012 |
Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colchicine; HeLa Cells; Humans; Microtubules; Models, Molecular; Structure-Activity Relationship; Thiazoles; Tubulin | 2012 |
Italian Society of Rheumatology recommendations for the management of gout.
Topics: Adrenal Cortex Hormones; Advisory Committees; Alcoholic Beverages; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Combined Modality Therapy; Dairy Products; Disease Management; Evidence-Based Medicine; Febuxostat; Female; Fructose; Gout; Humans; Italy; Male; Risk Factors; Smoking; Societies, Medical; Thiazoles; Uric Acid | 2013 |
Clinical and health care use characteristics of patients newly starting allopurinol, febuxostat, and colchicine for the treatment of gout.
Topics: Allopurinol; Ambulatory Care; Colchicine; Comorbidity; Febuxostat; Female; Gout; Gout Suppressants; Hospitalization; Humans; Male; Middle Aged; Office Visits; Thiazoles | 2013 |
Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics.
Topics: Cell Proliferation; Colchicine; Colonic Neoplasms; HCT116 Cells; Humans; Hydrogen Bonding; Microtubules; Mitosis; Molecular Dynamics Simulation; Protein Conformation; Thiazoles; Tubulin | 2014 |
Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.
Topics: Angiogenesis Inhibitors; Animals; Antimitotic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line, Tumor; Cell Movement; Colchicine; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred BALB C; Protein Binding; Stilbenes; Structure-Activity Relationship; Thiazoles; Tubulin Modulators; Xenograft Model Antitumor Assays | 2015 |
Possible neuroprotective mechanisms of clove oil against icv-colchicine induced cognitive dysfunction.
Topics: Acetylcholinesterase; Animals; Brain; Clove Oil; Cognition Disorders; Colchicine; Drug Synergism; Electron Transport Complex IV; Infusions, Intraventricular; Male; Minocycline; Mitochondria; NADH Dehydrogenase; Neuroprotective Agents; Oxidative Stress; Rats; Succinate Dehydrogenase; Tetrazolium Salts; Thiazoles | 2016 |
Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]triazoles as potent tubulin polymerization inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Structure; Polymerization; Structure-Activity Relationship; Thiazoles; Triazoles; Tubulin; Tubulin Modulators | 2023 |