Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and bms 387032

thiazoles has been researched along with bms 387032 in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's16 (36.36)29.6817
2010's25 (56.82)24.3611
2020's3 (6.82)2.80

Authors

AuthorsStudies
Ahmed, SZ; Barbosa, SA; Batorsky, R; Bednarz, MS; Chen, BC; Han, WC; Hunt, JT; Kamath, A; Kellar, KA; Kim, KS; Kimball, SD; Lee, FY; Lu, S; Marathe, P; Misra, RN; Mulheron, JG; Pavletich, NP; Qian, L; Ranadive, SA; Rawlins, DB; Roongta, U; Sack, JS; Shan, W; Tokarski, JS; Webster, KR; Xiao, HY; Zhao, R1
Chang, M; Chong, S; Kamath, AV; Marathe, PH1
Cress, WD; Freeman, SN; Ma, Y1
Blagden, S; de Bono, J1
Ali, MA; Carreon, P; Choy, H; Mukhopadhyay, P; Nandi, A; Saha, D1
Cress, WD; Ma, Y1
Ali, MA; Choy, H; Habib, AA; Saha, D1
Adelman, DC; Bible, K; Heath, EI; Lorusso, PM; Martell, RE1
Arkin, MR; Chan, E; Cheeti, S; Choong, IC; Fahr, B; Fan, J; Hoch, U; Lu, Y; Pham, P; Serafimova, I; Stockett, D; Walker, DH1
Chan, E; Cheeti, S; Choong, IC; Fahr, B; Fan, J; Hoch, U; Lu, Y; Pham, P; Serafimova, I; Stockett, D; Walker, DH1
Bentley, C; Borgognoni, J; Cansfield, AD; Curtin, NJ; Denny, S; Jackson, PS; Kierstan, P; Lockie, AM; Moore, JD; Newell, DR; Scrace, SF; Wang, LZ; Wayne, J; Williamson, DS1
Arkin, MR; Conroy, A; Fox, JA; Hawtin, RE; Hoch, U; Stockett, DE; Walker, D1
Habib, AA; Kodym, E; Kodym, R; Reis, AE; Saha, D; Story, MD1
Chen, R; Chubb, S; Fox, JA; Gandhi, V; Hawtin, RE; Keating, MJ; Plunkett, W; Wierda, WG1
Ali, MA; Chattopadhyay, A; Ding, LH; Habib, AA; Reis, A; Saha, D; Story, MD1
Boquoi, A; Chen, T; Enders, GH1
Badros, AZ; Chen, R; Chen, T; Coutre, S; Fox, JA; Harvey, RD; Hoch, U; Kegley, P; Mahadocon, K; Plunkett, W; Popplewell, L; Siegel, D; Sinha, R; Tong, WG; Wierda, WG1
Chen, R; Cheng, T; Chubb, S; Gandhi, V; Hawtin, RE; Plunkett, W1
Bantscheff, M; Drewes, G; Eberhard, D; Frenzel, L; Ghidelli, S; Kruse, U; Maier, SK; Pallasch, CP; Wendtner, CM; Werner, T1
Chen, R; Chen, Y; Guo, L; Jiang, Y; Plunkett, W; Wierda, WG1
Burnett, AK; Lazenby, M; Pepper, C; Walsby, E1
Chen, C; Ding, K; Jin, B; Pan, J; Shi, X; Sun, X; Wu, Y; Yeung, SC1
Jin, Y; Liu, H; Meng, H; Qian, W; Yang, C; Yang, X; You, L1
Cheng, T; Gao, YD; Ji, Q; Qi, RZ; Xu, J; Yuan, WP; Zhang, LY; Zhang, Y1
Chen, J; Liao, C; Liu, J; Tang, H; Wu, S; Xie, G1
Agadjanian, H; Allen, JR; Aspuria, PJ; Cheon, DJ; Funari, V; Greenberg, D; Karlan, BY; Mizuno, T; Orsulic, S; Spiteri, E; Spurka, L; Taylor-Harding, B; Walsh, C; Wang, Q; Wiedemeyer, WR1
Aza-Blanc, P; Matsuzawa, S; Reed, JC; Shi, R; Yanagi, T1
Ceckova, M; Cihalova, D; Staud, F1
Han, YX; Liu, H; Mao, LP; Qian, WB; Ye, XJ; You, LS1
Chen, H; Ding, HF; Dong, Z; Fang, D; Huang, S; Jing, Q; Lu, Y; Su, SB; Yang, L1
Anastasina, M; Bamford, DH; De Brabander, JK; Islam, MM; Julkunen, I; Kainov, D; Matikainen, S; Nyman, TA; Poranen, MM; Saelens, X; Šaulienė, I; Söderholm, S; Stenman, J; Tynell, J1
Giordano, A; Morales, F1
Balónová, B; Blight, BA; Cinatl, J; Löschmann, N; Michaelis, M; Rothweiler, F; Voges, Y1
Bamford, DH; Bugai, A; De Brabander, J; Fu, Y; Gaelings, L; Hukkanen, V; Julkunen, I; Kainov, DE; Kuisma, M; Le Goffic, R; Lorey, MB; Marjomäki, V; Matikainen, S; Miller, MS; Nandania, J; Nyman, TA; Paavilainen, H; Saelens, X; Schepens, B; Söderholm, S; Tynell, J; Vande Ginste, L; Velagapudi, V1
Chen, X; Ge, Y; He, X; Lei, W; Ma, Y; Mou, X; Ru, G; Wang, S; Wang, Y; Wei, B1
Chang, BCH; Cowley, KJ; Gasser, RB; Jabbar, A; Jiao, Y; Koehler, AV; Laleu, B; Palmer, MJ; Preston, S; Simpson, KJ; Stroehlein, AJ; Wells, TNC1
Adnan-Awad, S; Aittokallio, T; Anders, S; Andersson, EI; Bellanger, D; Brümmendorf, TH; Crispatzu, G; Cuesta-Mateos, C; Ding, W; Dufva, O; Eldfors, S; Ellonen, P; Faber, E; He, L; Herling, M; Huber, W; Kallioniemi, O; Khan, S; Koschmieder, S; Kytölä, S; Lagström, S; Lauhio, A; Mpindi, JP; Mustjoki, S; Oleś, M; Pemovska, T; Pietarinen, P; Pützer, S; Savolainen, ER; Schrader, A; Sellner, L; Siitonen, T; Stern, MH; Tang, J; Tomska, K; Wennerberg, K; Yadav, B; Zenz, T; Zhang, H1
Boukhali, M; Bradner, JE; Doctor, ZM; Erb, MA; Fischer, ES; Gray, NS; Green, JL; Haas, W; Jiang, B; Kwiatkowski, N; Liang, Y; Nomanbhoy, T; Olson, CM; Winter, GE; Young, RA; Zhang, T; Zhang, Z1
Jeong, JH; Jo, HR; Kang, MA; Kim, MH; Kim, W; Shin, YJ1
Brors, B; Huber, W; Hüllein, J; Kurilov, R; Lee, KS; Lukas, M; Oleś, M; Sellner, L; Tomska, K; Wagner, L; Walther, T; Zenz, T1
Liu, S; Pan, J; Ye, Q; Zhang, J1
Hu, L; Li, Y; Ruan, C; Wang, Q; Wang, S; Ye, M; Zhang, X1
Chen, L; Fang, D; Song, Y; Wang, C; Xie, S; Yang, H; Zeng, H; Zhao, Z1
Chen, X; Ding, W; Jiang, L; Liu, A; Liu, J; Shi, X; Wen, C; Zhang, H; Zhou, H1

Reviews

2 review(s) available for thiazoles and bms 387032

ArticleYear
Drugging cell cycle kinases in cancer therapy.
    Current drug targets, 2005, Volume: 6, Issue:3

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles

2005
Overview of CDK9 as a target in cancer research.
    Cell cycle (Georgetown, Tex.), 2016, Volume: 15, Issue:4

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Flavonoids; Humans; Indolizines; Molecular Targeted Therapy; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridinium Compounds; Roscovitine; Thiazoles; Urea

2016

Trials

3 trial(s) available for thiazoles and bms 387032

ArticleYear
A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors.
    Investigational new drugs, 2008, Volume: 26, Issue:1

    Topics: Administration, Oral; Adult; Aged; Anemia; Angiogenesis Inhibitors; Area Under Curve; Biological Availability; CDC2-CDC28 Kinases; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Neutropenia; Oxazoles; Radiotherapy, Adjuvant; Thiazoles; Time Factors; Treatment Outcome

2008
SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma; Oxazoles; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles

2009
Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jun-20, Volume: 28, Issue:18

    Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Cohort Studies; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Maximum Tolerated Dose; Middle Aged; Multiple Myeloma; Oxazoles; Survival Rate; Thiazoles; Tissue Distribution; Treatment Outcome

2010

Other Studies

39 other study(ies) available for thiazoles and bms 387032

ArticleYear
N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Animals; Antineoplastic Agents; CDC2-CDC28 Kinases; Cell Line, Tumor; Cell-Free System; Crystallography, X-Ray; Cyclin E; Cyclin-Dependent Kinase 2; Dogs; Drug Screening Assays, Antitumor; Drug Stability; Humans; In Vitro Techniques; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Neoplasm Transplantation; Oxazoles; Phosphorylation; Rats; Retinoblastoma Protein; Structure-Activity Relationship; Thiazoles; Transplantation, Heterologous

2004
P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats.
    Cancer chemotherapy and pharmacology, 2005, Volume: 55, Issue:2

    Topics: Absorption; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Brain; Caco-2 Cells; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Dogs; Humans; Male; Mice; Microsomes, Liver; Oxazoles; Photoaffinity Labels; Rats; Rats, Sprague-Dawley; Thiazoles

2005
E2F4 deficiency promotes drug-induced apoptosis.
    Cancer biology & therapy, 2004, Volume: 3, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; Fibroblasts; Flavonoids; Humans; Lung Neoplasms; Mice; Mice, Knockout; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Roscovitine; Thiazoles; Transcription Factors; Tumor Cells, Cultured

2004
The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells.
    Cancer research, 2006, Feb-01, Volume: 66, Issue:3

    Topics: Carcinoma, Non-Small-Cell Lung; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclooxygenase 2; Dinoprostone; Down-Regulation; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1; Lung Neoplasms; Oxazoles; Promoter Regions, Genetic; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Thiazoles; Transcription, Genetic; Transfection

2006
Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity.
    Oncogene, 2007, May-24, Volume: 26, Issue:24

    Topics: Binding Sites; Cell Cycle; Cell Line; Cyclin-Dependent Kinase Inhibitor p57; Cyclin-Dependent Kinases; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation; Humans; Oxazoles; Promoter Regions, Genetic; Thiazoles; Transcription, Genetic; Up-Regulation

2007
SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor.
    Neoplasia (New York, N.Y.), 2007, Volume: 9, Issue:5

    Topics: Angiogenesis Inhibitors; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Endothelial Cells; Glioblastoma; Humans; Neovascularization, Pathologic; Oxazoles; Protein Kinase Inhibitors; Thiazoles; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A

2007
A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
    Bioorganic & medicinal chemistry letters, 2008, Nov-01, Volume: 18, Issue:21

    Topics: Animals; Biological Availability; Mice; Oxazoles; Permeability; Thiazoles

2008
Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.
    Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23

    Topics: Animals; Combinatorial Chemistry Techniques; Cyclin-Dependent Kinase 2; Isonipecotic Acids; Mice; Molecular Structure; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles

2008
Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked.
    Cell cycle (Georgetown, Tex.), 2008, Dec-15, Volume: 7, Issue:24

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Cyclin-Dependent Kinases; DNA Damage; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Pyrimidines; RNA, Small Interfering; Thiazoles; X-Linked Inhibitor of Apoptosis Protein

2008
The small-molecule CDK inhibitor, SNS-032, enhances cellular radiosensitivity in quiescent and hypoxic non-small cell lung cancer cells.
    Lung cancer (Amsterdam, Netherlands), 2009, Volume: 66, Issue:1

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Cyclin-Dependent Kinases; Humans; Lung Neoplasms; Oxazoles; Radiation Tolerance; Thiazoles

2009
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
    Blood, 2009, May-07, Volume: 113, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Caspases; Cyclin-Dependent Kinases; Female; Flavonoids; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Male; Membrane Potential, Mitochondrial; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Neoplasm; Roscovitine; Thiazoles; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein

2009
SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression.
    International journal of oncology, 2009, Volume: 34, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Collagen; Cyclooxygenase 2 Inhibitors; DNA Primers; Drug Combinations; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Laminin; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Oxazoles; Proteoglycans; RNA, Small Interfering; Thiazoles; Vascular Endothelial Growth Factor A

2009
Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:9

    Topics: ADP-Ribosylation Factor 1; Animals; Apoptosis; Cell Cycle; Colitis; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Female; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazoles; Phosphorylation; Protein Kinase Inhibitors; Thiazoles

2009
Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.
    Cancer research, 2010, Aug-15, Volume: 70, Issue:16

    Topics: Cell Cycle; Cell Death; Cell Growth Processes; Cell Line, Tumor; Cyclin D1; Humans; Lymphoma, Mantle-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Proto-Oncogene Proteins c-bcl-2; RNA, Neoplasm; RNA, Small Nuclear; Thiazoles; Transfection

2010
Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.
    Leukemia, 2011, Volume: 25, Issue:1

    Topics: Apoptosis; Flavonoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Oxazoles; Piperidines; Positive Transcriptional Elongation Factor B; Protein Kinase Inhibitors; Proteomics; Thiazoles

2011
Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia.
    Blood, 2011, Jan-06, Volume: 117, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Proliferation; Drug Synergism; Drug Therapy, Combination; Harringtonines; Homoharringtonine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Middle Aged; Mitochondrial Membranes; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Thiazoles; Tumor Cells, Cultured

2011
The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine.
    Leukemia, 2011, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinases; Cytarabine; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Oxazoles; Phosphorylation; Thiazoles

2011
Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Apr-01, Volume: 18, Issue:7

    Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Female; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred BALB C; Mice, Nude; mRNA Cleavage and Polyadenylation Factors; Oncogene Proteins, Fusion; Oxazoles; Phosphorylation; Receptor, Platelet-Derived Growth Factor alpha; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays

2012
SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt.
    Journal of hematology & oncology, 2013, Feb-18, Volume: 6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Proliferation; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Leukemia, Myeloid, Acute; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Oxazoles; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Tumor Cells, Cultured

2013
[Effect of SNS-032 on biological activity of hematopoietic stem cells in mice].
    Zhongguo shi yan xue ye xue za zhi, 2013, Volume: 21, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Oxazoles; Thiazoles

2013
The cyclin-dependent kinase inhibitor SNS-032 induces apoptosis in breast cancer cells via depletion of Mcl-1 and X-linked inhibitor of apoptosis protein and displays antitumor activity in vivo.
    International journal of oncology, 2014, Volume: 45, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase 2; Female; Heterografts; Humans; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Real-Time Polymerase Chain Reaction; Thiazoles; X-Linked Inhibitor of Apoptosis Protein

2014
Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS.
    Oncotarget, 2015, Jan-20, Volume: 6, Issue:2

    Topics: Animals; Cyclin E; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; E2F Transcription Factors; Female; Humans; Mice; Mice, Nude; Oncogene Proteins; Ovarian Neoplasms; Oxazoles; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Proto-Oncogene Proteins p21(ras); Pyridines; Random Allocation; ras Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thiazoles; Transcription, Genetic; Xenograft Model Antitumor Assays

2015
PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Cyclin-Dependent Kinases; Cytokines; Fas-Associated Death Domain Protein; HEK293 Cells; HeLa Cells; Humans; Oxazoles; Receptor-Interacting Protein Serine-Threonine Kinases; RNA Interference; RNA, Messenger; RNA, Small Interfering; Thiazoles; TNF-Related Apoptosis-Inducing Ligand

2015
Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.
    Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:1

    Topics: Animals; ATP-Binding Cassette Transporters; Cell Proliferation; Dogs; Drug Interactions; Drug Resistance, Multiple; Flavonoids; Humans; Madin Darby Canine Kidney Cells; Oxazoles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Thiazoles

2015
[Apoptosis of acute myeloid leukemia HL-60 cells induced by CDK inhibitor SNS-032 and its molecular mechanisms].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2015, Volume: 44, Issue:2

    Topics: Apoptosis; Cell Survival; Down-Regulation; Flow Cytometry; HL-60 Cells; Humans; Janus Kinase 2; MicroRNAs; Oxazoles; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Thiazoles

2015
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression.
    Oncotarget, 2015, Aug-28, Volume: 6, Issue:25

    Topics: Animals; Apoptosis; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Oncogene Proteins; Ovarian Neoplasms; Oxazoles; RNA, Small Interfering; Thiazoles; Triazoles

2015
Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.
    Antiviral research, 2016, Volume: 126

    Topics: Amides; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Coinfection; Cytokines; Deoxycytidine; Gemcitabine; Humans; Immunity, Innate; Immunologic Factors; Indoles; Influenza A virus; Influenza, Human; Interferon-alpha; Lipopolysaccharides; Macrophages; Oxazoles; Phosphoproteins; Pyrroles; RNA, Viral; Salicylates; Thiazoles; Virus Replication

2016
ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
    Oncotarget, 2016, Sep-06, Volume: 7, Issue:36

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neuroblastoma; Oxazoles; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; RNA Interference; RNA, Small Interfering; Sulfonamides; Thiazoles

2016
Regulation of kynurenine biosynthesis during influenza virus infection.
    The FEBS journal, 2017, Volume: 284, Issue:2

    Topics: Animals; Antiviral Agents; Female; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Influenza A Virus, H1N1 Subtype; Interferons; Kynurenine; Lung; Macrophages; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Oxazoles; Oximes; Primary Cell Culture; Pyrroles; Sulfonamides; Thiazoles; Transcriptome; Tryptophan; Viral Nonstructural Proteins; Virus Replication

2017
Synergistic antitumor effects of CDK inhibitor SNS‑032 and an oncolytic adenovirus co‑expressing TRAIL and Smac in pancreatic cancer.
    Molecular medicine reports, 2017, Volume: 15, Issue:6

    Topics: Adenoviridae; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mitochondrial Proteins; Oncolytic Virotherapy; Oncolytic Viruses; Oxazoles; Pancreatic Neoplasms; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays

2017
Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.
    Parasites & vectors, 2017, Jul-05, Volume: 10, Issue:1

    Topics: Amino Acid Sequence; Animals; Antinematodal Agents; Cell Line; Dose-Response Relationship, Drug; Haemonchiasis; Haemonchus; Humans; Larva; Models, Molecular; Oxazoles; Protein Kinase Inhibitors; Sequence Alignment; Small Molecule Libraries; Thiazoles; Tyrphostins

2017
Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.
    Leukemia, 2018, Volume: 32, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Chromosome Aberrations; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Gene Expression; Gene Expression Profiling; High-Throughput Screening Assays; Humans; Janus Kinases; Leukemia, Prolymphocytic, T-Cell; Male; Middle Aged; Molecular Targeted Therapy; Mutation; Oxazoles; Phenotype; Protein Kinase Inhibitors; STAT Transcription Factors; Thiazoles

2018
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
    Nature chemical biology, 2018, Volume: 14, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Cyclin-Dependent Kinase 9; Humans; Inhibitory Concentration 50; Ligands; Oxazoles; Peptide Hydrolases; Phosphorylation; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Proteomics; Thalidomide; Thiazoles; Ubiquitin-Protein Ligases

2018
Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer.
    International journal of oncology, 2018, Volume: 53, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinases; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Lung Neoplasms; Mice; Oxazoles; Piperidines; Pyrazoles; Radiation-Sensitizing Agents; Thiazoles; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2018
Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma.
    Scientific reports, 2018, 08-13, Volume: 8, Issue:1

    Topics: Acetanilides; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Burkitt Lymphoma; Cell Line, Tumor; Drug Combinations; Drug Synergism; Heterocyclic Compounds, 3-Ring; Humans; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thiazoles

2018
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.
    Molecular cancer, 2019, 09-16, Volume: 18, Issue:1

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Liver Neoplasms; Male; Melanoma; Mice; Oncogene Addiction; Oxazoles; Signal Transduction; Thiazoles; Transcription Factors; Uveal Neoplasms; Xenograft Model Antitumor Assays

2019
Solvent-Induced Protein Precipitation for Drug Target Discovery on the Proteomic Scale.
    Analytical chemistry, 2020, 01-07, Volume: 92, Issue:1

    Topics: Acetic Acid; Acetone; Cells, Cultured; Drug Discovery; Drug Evaluation, Preclinical; Ethanol; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; HSP90 Heat-Shock Proteins; Humans; Methotrexate; NADH Dehydrogenase; Oxazoles; Proteomics; Solvents; Staurosporine; Thiazoles

2020
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 suppresses tumor growth and metastasis in esophageal squamous cell carcinoma.
    Cell death & disease, 2021, 11-05, Volume: 12, Issue:11

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Drug Synergism; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Humans; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Invasiveness; Neoplasm Metastasis; Oxazoles; Thiazoles; Transcription, Genetic; Tumor Burden; Wound Healing

2021
Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells.
    Cancer biology & therapy, 2022, 12-31, Volume: 23, Issue:1

    Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Nude; Neoplasm Recurrence, Local; Oxazoles; Thiazoles

2022