thiazoles has been researched along with benzofurans in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (12.00) | 18.7374 |
| 1990's | 10 (13.33) | 18.2507 |
| 2000's | 17 (22.67) | 29.6817 |
| 2010's | 33 (44.00) | 24.3611 |
| 2020's | 6 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Canevari, R; Gressier, H; Petitjean, M; Poignant, JC; Regnier, G | 1 |
| Haigney, MC; Lakatta, EG; Miyata, H; Silverman, HS; Stern, MD | 1 |
| Clark, DA; Eggler, JF; Gibbs, EM; Goldstein, SW; Holland, GF; Hulin, B; Kreutter, DK; Krupp, MN; Stevenson, RW; Volkmann, RA | 1 |
| Bittner, C; Lambrecht, G; Parnham, MJ | 1 |
| Beattie, TR; Biftu, T; Hwang, SB; Lam, MH; Shen, TY | 1 |
| Tokumura, A; Tsukatani, H | 1 |
| Hwang, SB; Lam, MH | 1 |
| Benveniste, J; Braquet, P; Chignard, M; Korth, R; Le Couedic, JP; Norel, X; Nunez, D; Spinnewyn, B | 1 |
| Braquet, P; Neuwirth, R; Satriano, JA; Schlondorff, D; Singhal, P | 1 |
| Baggiolini, M; Dewald, B | 1 |
| Braud, J; Héraud, G; Léonard, C; Roux, E | 1 |
| Haigney, MC; Lakatta, EG; Silverman, HS; Stern, MD | 1 |
| Brideau, C; Chan, CC; Dubé, D; Ducharme, Y; Falgueyret, JP; Gillard, JW; Guay, J; Hutchinson, JH; McFarlane, CS; Riendeau, D | 1 |
| Falgueyret, JP; Hutchinson, JH; Riendeau, D | 1 |
| Freund, P; Heitzmann, T; Neidlein, R; Reiff, K; Strein, K | 1 |
| Rainsford, KD; Smith, F; Ying, C | 1 |
| Clark, DA; Genereux, PE; Gibbs, EM; Hulin, B; Lewis, DM; Newton, LS | 1 |
| Gundlach, AL; Hosseini, AR; Iakovidis, D; Jackman, GP; King, PR; Louis, WJ; Nero, TL; Suzuki, S | 1 |
| Gundlach, AL; King, PR; Louis, WJ | 1 |
| Boscá, L; Castrillo, A; Hortelano, S; Mojena, M | 1 |
| Culver, KE; Szechtman, H | 1 |
| Baba, T; Inagaki, M; Iwatani, K; Jyoyama, H; Kobayashi, M; Matsumoto, S; Ohkawa, T; Ono, T; Touchi, A; Tsuri, T; Yamada, K | 1 |
| Hadfield, JA; Lawrence, NJ; McGown, AT; Rennison, D | 1 |
| Bharatam, PV; Khanna, S; Sobhia, ME | 1 |
| Asensio, VJ; Esteban, S; García-Sevilla, JA; Miralles, A; Moranta, D; Sastre-Coll, A | 1 |
| Anderson, NJ; Hudson, AL; Lupo, PA; Nutt, DJ; Robinson, ES | 1 |
| Anderson, NJ; Hudson, AL; Nutt, DJ; Robinson, ES; Seif, I | 1 |
| Bratton, L; Cheng, XM; Erasga, N; Filzen, GF; Geyer, A; Lee, C; Lu, G; Pulaski, J; Sorenson, RJ; Trivedi, BK; Unangst, PC; Xu, X | 1 |
| Guo, ZX; Xiang, ZJ; Ye, TX; Yuan, YJ; Zhang, HM; Zhao, GR; Zhao, LB | 1 |
| Ahmedzade, M; Cukurovali, A; Kazaz, C; Koca, M | 1 |
| Li, H; Luo, P; Mo, Z; Tan, Z; Zhang, Z | 1 |
| Kawasaki, I; Kunitomo, J; Kuramoto, M; Ohishi, T; Ohishi, Y; Sakata, Y; Takeda, S; Tanaka, S; Terai, K; Yokomizo, T | 1 |
| Aliaga, M; Assié, MB; Barbara, M; Bardin, L; Carilla-Durand, E; Malfètes, N; Maraval, M; Newman-Tancredi, A | 1 |
| Ee, PL; Go, ML; Lee, CY; Sim, HM | 1 |
| Byun, JH; Kim, DJ; Kim, H; Kim, Y; Lee, WK; Mook-Jung, I; Yoo, KH | 1 |
| Bahar, I; Follis, AV; Hammoudeh, DI; Lazo, JS; Metallo, SJ; Mustata, G; Prochownik, EV; Wang, H | 1 |
| Aggarwal, S; Bhardwaj, TR; Kumar, M; Thareja, S | 1 |
| Bettica, P; Boyle, G; Nash, M; Pellegatti, M; Renzulli, C; Thomas, S; Wright, M; Zamuner, S | 1 |
| Choi, MJ; Hong, S; Hong, SS; Hong, SW; Jung, KH; Kim, D; Kim, MH; Lee, H; Park, BH; Zheng, HM | 1 |
| Fernández-Salguero, PM; Merino, JM; Sánchez-Martín, FJ | 1 |
| Cai, Z; Leung, AO; Liu, WK; Wong, CK; Wong, MH; Yu, CK; Zheng, J | 1 |
| Alexander, R; Bettica, P; Gomeni, R; Nucci, G; Pyke, C; Ratti, E; Squassante, L; Zamuner, S | 1 |
| Chen, L; Li, W; Xu, L; Zhou, Y | 1 |
| Duarte, FV; Palmeira, CM; Rolo, AP; Teodoro, JS | 1 |
| Bettica, P; Dijk, DJ; Gennery, B; Groeger, JA; Squassante, L; Winsky-Sommerer, R | 1 |
| Hussar, DA | 1 |
| Choi, MJ; Hong, S; Hong, SS; Jung, KH; Kim, D; Lee, H; Lee, JH | 1 |
| Cencic, R; Galicia-Vázquez, G; Pelletier, J | 1 |
| Antolini, M; Corsi, M; di Fabio, R; Faedo, S; Merlo Pich, E; Perdonà, E | 1 |
| Bettica, P; Danker-Hopfe, H; Nucci, G; Ratti, E; Squassante, L; Zamuner, S | 1 |
| Chan, JG; Cselényi, Z; Jones, G; Masters, CL; Mulligan, RS; Pejoska, S; Rowe, CC; Svensson, S; Villemagne, VL | 1 |
| Huang, R; Lin, Y; Qiu, SX; She, Z; Yang, J | 1 |
| Czajkowska, B; Krzystanek, M; Lapray, D; Markowski, G; Pałasz, A; Peyron, C; Rojczyk-Gołębiewska, E; Skowronek, R; Wiaderkiewicz, R | 1 |
| Amini, N; Bergman, L; Cselenyi, Z; Farde, L; Gulyas, B; Halldin, C; Johnström, P; Lindström-Böö, E; Nakao, R; Sandell, J; Schou, M; Sumic, A; Svensson, S; Varnäs, K | 1 |
| Jeon, YJ; Ko, SC; Lee, JH; Lee, M; Lee, SH; Lim, Y | 1 |
| Hoyer, D; Jacobson, LH | 1 |
| Bullmore, ET; Kanakaraj, P; Koch, A; Lawrence, P; Miller, SR; Napolitano, A; Nathan, PJ; Patel, AX | 1 |
| Choi, SJ; Jin, G; Nho, JH; Oh, SY; Ryu, CK | 1 |
| Ahn, SJ; Cho, EJ; Choi, MH; Kook, JK; Lee, YJ; Li, XM; Lim, YK; Park, SN; Seo, YW | 1 |
| Basile, L; Gazioglu, I; Ginex, T; Guccione, S; Kucukislamoglu, M; Kurt, BZ; Sonmez, F | 1 |
| Chan, JG; Doré, V; Jones, G; Margison, L; Mulligan, RS; Pejoska, S; Rowe, CC; Villemagne, VL; Young, K | 1 |
| Desantis, J; Goracci, L; Massari, S; Tabarrini, O | 1 |
| Agarwal, K; Barr, E; Ben-Ari, Z; Butterton, JR; Chen, HL; Dutko, FJ; Esteban, R; Fernsler, D; Fitzgerald, B; Foster, GR; Gane, EJ; Gao, W; Gerstoft, J; Grandhi, A; Huang, HC; Laursen, AL; Li, JJ; Liu, H; Nguyen, BT; Pianko, S; Plank, RM; Roberts, SK; Robertson, MN; Su, FH; Thompson, AJ; Wahl, J; Wan, S; Yeh, WW; Zeng, Z; Zeuzem, S; Zuckerman, E | 1 |
| Kantevari, S; Marvadi, SK; Sriram, D; Surineni, G; Yogeeswari, P | 1 |
| Babsky, A; Finiuk, N; Hreniukh, V; Ivasechko, I; Klyuchivska, O; Matiychuk, V; Obushak, M; Ostapiuk, Y; Panchuk, R; Shalai, Y; Stoika, R | 1 |
| Chen, C; Chen, F; Chen, P; Kong, Y; Ren, S; Song, H; Sun, H; Xu, Q | 1 |
| Almeida, FG; Bernardo, WM; Sacomani, CAR; Silvinato, A | 1 |
| Hansson, F; Kilany, S; Milsom, I; Schiotz, HA; Svensson, M | 1 |
| Ayine-Tora, DM; Chand, R; Chepanova, AA; Dyrkheeva, NS; Filimonov, AS; Ilina, ES; Khachatryan, DS; Kolotaev, AV; Kuprushkin, MS; Lavrik, OI; Leung, IKH; Luzina, OA; Patel, J; Reynisson, J; Salakhutdinov, NF; Volcho, KP; Zakharenko, AL; Zakharova, OD | 1 |
| Amador, LA; Cencic, R; Itoua Maïga, R; Jankowsky, E; Naineni, SK; Pelletier, J; Putnam, AA; Rodriguez, AD | 1 |
| Casoni, D; Coman, FM; Leonte, D; Toma, A; Vlase, L; Zaharia, V | 1 |
| Chaudhry, N; Kumar, A; Kumar, N; Nagendra Rao, S; Patel, S; Prasad, V; Vasudeva, P; Yadav, P; Yadav, S | 1 |
| Balapragalathan, TJ; Banville, J; Bouvier, M; Callejo, M; Cvijic, ME; Deon, D; Dubé, L; Gagnon, M; Gordon, DA; Guarino, VR; Guay, J; Gupta, A; Guy, J; Hua, J; Lapointe, P; Lavallée, JF; Li, J; Marinier, A; Martel, A; Mathur, A; Plamondon, S; Posy, SL; Priestley, ES; Rémillard, R; Richter, JM; Ruediger, E; Sum, CS; Tremblay, F; Vetrichelvan, M; Watson, C; Wexler, RR; Wong, P; Yang, J | 1 |
| Bouvier, M; Callejo, M; DeSouza, MM; Frost, C; Hedrick, M; Hui, L; Meadows Shropshire, S; Merali, S; Wang, Z; Xu, K; Yang, J | 1 |
| Dhaduk, BB; Hadiyal, SD; Joshi, HS; Lalpara, JN | 1 |
5 review(s) available for thiazoles and benzofurans
| Article | Year |
|---|---|
[Antagonists of platelet activating factor].
Topics: Animals; Benzofurans; Benzopyrans; Depression, Chemical; Guinea Pigs; Lignans; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Thiazoles | 1985 |
Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus.
Topics: Acetophenones; Amino Acid Sequence; Animals; Benzoates; Benzofurans; Biphenyl Compounds; Blood Glucose; Catalytic Domain; Catechols; Chromones; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fluorides; Humans; Insulin; Insulin Resistance; Insulin Secretion; Janus Kinase 2; Models, Molecular; Naphthoquinones; Peptidomimetics; Phosphates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyridazines; Receptor, Insulin; Signal Transduction; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Thiophenes; Vanadium Compounds | 2012 |
Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
Topics: Acetamides; Animals; Azepines; Benzofurans; Humans; Isoquinolines; Models, Biological; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles; Wakefulness | 2014 |
Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
Topics: Acetamides; Animals; Azepines; Behavior, Addictive; Benzofurans; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Mice; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Piperidines; Pyrimidines; Rats; Reward; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles | 2013 |
Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Protein-Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics.
Topics: Animals; Antiviral Agents; Benzofurans; Drug Resistance, Viral; Humans; Multiprotein Complexes; Orthomyxoviridae; Peptides; Pyrazoles; Pyridines; Pyrimidines; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Thiazoles; Thiophenes; Viral Proteins | 2016 |
9 trial(s) available for thiazoles and benzofurans
| Article | Year |
|---|---|
Disposition and metabolism of [14C]SB-649868, an orexin 1 and 2 receptor antagonist, in humans.
Topics: Administration, Oral; Adult; Benzofurans; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Feces; Humans; Male; Mass Spectrometry; Middle Aged; Molecular Structure; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Thiazoles; Tissue Distribution | 2011 |
Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist.
Topics: Adolescent; Adult; Arousal; Benzofurans; Cognition; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Half-Life; Humans; Hypnotics and Sedatives; Male; Middle Aged; Orexin Receptors; Polysomnography; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Simvastatin; Single-Blind Method; Sleep; Sleep Stages; Thiazoles; Wakefulness | 2012 |
Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia.
Topics: Adolescent; Adult; Analysis of Variance; Benzofurans; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; GABA-A Receptor Agonists; Humans; Male; Middle Aged; Neuropsychological Tests; Orexin Receptors; Polysomnography; Psychomotor Performance; Pyridines; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep Initiation and Maintenance Disorders; Sleep, REM; Surveys and Questionnaires; Thiazoles; Wakefulness; Young Adult; Zolpidem | 2012 |
The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia.
Topics: Adolescent; Adult; Benzofurans; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Germany; Humans; Intracellular Signaling Peptides and Proteins; Male; Memory; Middle Aged; Neuropeptides; Orexins; Placebos; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Surveys and Questionnaires; Thiazoles; Time Factors; Young Adult | 2012 |
Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for β-amyloid imaging in aging and dementia.
Topics: Aged; Aging; Amyloid beta-Peptides; Aniline Compounds; Benzofurans; Benzothiazoles; Brain; Dementia; Female; Humans; Hydrocarbons, Fluorinated; Male; Molecular Imaging; Positron-Emission Tomography; Thiazoles | 2013 |
Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and alprazolam following insulin-induced hypoglycemia in humans.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Alprazolam; Anti-Anxiety Agents; Benzofurans; Cross-Over Studies; Double-Blind Method; Growth Hormone; Heart Rate; Humans; Hypoglycemia; Insulin; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Neuropeptides; Neurosecretory Systems; Norepinephrine; Orexin Receptor Antagonists; Orexins; Prolactin; Sympathetic Nervous System; Thiazoles; Young Adult | 2014 |
Safety and efficacy of an 8-week regimen of grazoprevir plus ruzasvir plus uprifosbuvir compared with grazoprevir plus elbasvir plus uprifosbuvir in participants without cirrhosis infected with hepatitis C virus genotypes 1, 2, or 3 (C-CREST-1 and C-CREST
Topics: Adult; Aged; Amides; Antiviral Agents; Benzofurans; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Male; Middle Aged; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Thiazoles; Uridine; Young Adult | 2017 |
Neurological safety and efficacy of darifenacin and mirabegron for the treatment of overactive bladder in patients with history of cerebrovascular accident: A prospective study.
Topics: Acetanilides; Adult; Benzofurans; Humans; Prospective Studies; Pyrrolidines; Stroke; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive; Urological Agents | 2021 |
New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans.
Topics: Administration, Oral; Benzofurans; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Imidazoles; Morpholines; Platelet Aggregation; Receptors, Thrombin; Thiazoles | 2022 |
61 other study(ies) available for thiazoles and benzofurans
| Article | Year |
|---|---|
A new central direct dopaminergic stimulant: 1-(Coumaran-5-yl methyl)-4-(2-thiazolyl) piperazine hydrochloride (S 3608).
Topics: Animals; Apomorphine; Behavior, Animal; Benzofurans; Catatonia; Corpus Striatum; Drug Interactions; Ergolines; Humans; Hydroxydopamines; Male; Morphine; Piperazines; Rats; Stereotyped Behavior; Substantia Nigra; Thiazoles; Yohimbine | 1975 |
Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange.
Topics: Animals; Benzofurans; Benzothiazoles; Calcium; Cell Hypoxia; Ethers, Cyclic; Hydrogen-Ion Concentration; Indoles; Ischemia; Myocardium; Piperidines; Rats; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Thiazoles | 1992 |
Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents.
Topics: Adipose Tissue; Animals; Benzofurans; Biological Transport, Active; Cell Line; Deoxyglucose; Hyperglycemia; Hypoglycemic Agents; Indicators and Reagents; Mice; Mice, Obese; Molecular Structure; Monosaccharide Transport Proteins; Muscles; Structure-Activity Relationship; Thiazoles | 1991 |
Antagonism of platelet activating factor-induced chemiluminescence in guinea-pig peritoneal macrophages in differing states of activation.
Topics: Alprazolam; Animals; Benzofurans; Diterpenes; Furans; Ginkgolides; Guinea Pigs; In Vitro Techniques; Lactones; Lignans; Luminescent Measurements; Macrophage Activation; Macrophages; Male; Platelet Activating Factor; Thiazoles | 1989 |
trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor.
Topics: Animals; Benzofurans; Benzopyrans; Blood Platelets; Bradykinin; Capillary Permeability; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Furans; Histamine; Humans; Lignans; Magnesium; Mathematics; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sodium; Thiazoles | 1985 |
Species difference in the specific receptors of platelet activating factor.
Topics: Animals; Benzofurans; Blood Platelets; Cell Membrane; Diterpenes; Furans; Ginkgolides; Humans; Lactones; Lignans; Lung; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Thiophenes | 1986 |
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Benzofurans; Benzopyrans; Blood Platelets; Diterpenes; Ginkgolides; Humans; In Vitro Techniques; Lactones; Lignans; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Thiazoles | 1986 |
Effect of platelet activating factor antagonists on cultured rat mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Calcimycin; Cells, Cultured; Dinoprostone; Diterpenes; Dose-Response Relationship, Drug; Ginkgolides; Glomerular Mesangium; Lactones; Lignans; Male; Plant Extracts; Platelet Activating Factor; Prostaglandins E; Rats; Thiazoles | 1987 |
Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay.
Topics: Benzofurans; Diterpenes; Exocytosis; Fluorescence; Ginkgolides; Humans; Lactones; Lignans; Methods; Neutrophils; Pancreatic Elastase; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Pyridines; Thiazoles | 1987 |
[Letter: Hyperthyroidism and amiodarone].
Topics: Antihypertensive Agents; Benzofurans; Edema; Humans; Hyperthyroidism; Male; Middle Aged; Thiazoles | 1974 |
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.
Topics: Amiloride; Animals; Benzofurans; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Separation; Ethers, Cyclic; Fluorescent Dyes; Hypoxia; Lidocaine; Myocardial Contraction; Myocardium; Piperidines; Rats; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Tetrodotoxin; Thiazoles | 1994 |
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.
Topics: Animals; Benzofurans; Humans; Lactones; Lipoxygenase; Lipoxygenase Inhibitors; Male; Naphthalenes; Neutrophils; Pyrans; Rats; Rats, Sprague-Dawley; Saimiri; Structure-Activity Relationship; Thiazoles | 1994 |
Criteria for the identification of non-redox inhibitors of 5-lipoxygenase.
Topics: Arachidonate 5-Lipoxygenase; Benzeneacetamides; Benzofurans; Enzyme Inhibitors; Humans; Hydroxamic Acids; Hydroxyurea; Indoles; Leukotrienes; Lipid Peroxides; Lipoxygenase Inhibitors; Naphthalenes; Oxidation-Reduction; Thiazoles | 1993 |
Dose proportionality studies of novel thiazolidinedione derivatives as potent antidiabetic agents in mice.
Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Half-Life; Hypoglycemic Agents; Male; Mice; Mice, Inbred Strains; Naphthalenes; Oxazoles; Oxazolidinones; Spectrophotometry, Ultraviolet; Thiazoles; Thiazolidinediones | 1995 |
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
Topics: Animals; Benzofurans; Enzyme-Linked Immunosorbent Assay; Hip Joint; Humans; Hydroxyurea; Indoles; Interleukin-1; Knee Joint; Lipoxygenase Inhibitors; Naphthalenes; Organ Culture Techniques; Oxindoles; Pyrazoles; Quinolines; Structure-Activity Relationship; Swine; Synovial Membrane; Tarsus, Animal; Thiazoles; Thiophenes | 1996 |
Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone.
Topics: 3T3 Cells; Adipocytes; Animals; Benzofurans; Carboxylic Acids; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Mice; Mice, Mutant Strains; Mice, Obese; Molecular Structure; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 1996 |
[3H]Rilmenidine-labelled imidazoline-receptor binding sites co-localize with [3H]2-(benzofuranyl)-2-imidazoline-labelled imidazoline-receptor binding sites and monoamine oxidase-B in rabbit, but not rat, kidney.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Benzofurans; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isoenzymes; Kidney; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Rabbits; Rats; Rats, Inbred WKY; Receptors, Drug; Rilmenidine; Species Specificity; Thiazoles | 1998 |
Identification of imidazoline-receptor binding sites in cortex and medulla of the bovine adrenal gland. Colocalization with MAO-A and MAO-B.
Topics: Adrenal Cortex; Adrenal Medulla; Adrenergic beta-Agonists; Animals; Autoradiography; Benzofurans; Binding Sites; Cattle; Clonidine; Imidazoles; Imidazoline Receptors; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Rats; Receptors, Drug; Rilmenidine; Thiazoles; Tritium | 1999 |
Peroxisome proliferator-activated receptor-gamma-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-delta(12,14)-prostaglandin J(2).
Topics: Anions; Apoptosis; Benzofurans; Blotting, Northern; Blotting, Western; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cytosol; Dose-Response Relationship, Drug; Flow Cytometry; Genes, Reporter; Glutathione Transferase; I-kappa B Kinase; Immunohistochemistry; Kinetics; Ligands; Macrophage Activation; Macrophages; Microscopy, Confocal; NF-kappa B; Nitric Oxide; Phenylacetates; Plasmids; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Transfection | 2001 |
Clorgyline-induced switch from locomotion to mouthing in sensitization to the dopamine D2/D3 agonist quinpirole in rats: role of sigma and imidazoline I2 receptors.
Topics: Animals; Behavior, Animal; Benzofurans; Clorgyline; Dopamine; Dopamine Agonists; Drug Administration Schedule; Imidazoles; Imidazoline Receptors; Injections, Subcutaneous; Ligands; Male; Monoamine Oxidase Inhibitors; Motor Activity; Quinpirole; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Drug; Receptors, sigma; Thiazoles | 2003 |
Synthesis and activities of oxidative metabolites of the anti-arthritic drug candidate S-2474.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Cyclic S-Oxides; Dinoprostone; Edema; Humans; Interleukin-1; Leukotriene B4; Lipoxygenase Inhibitors; Microsomes, Liver; Rats; Thiazoles | 2003 |
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
Topics: Antineoplastic Agents, Phytogenic; Benzofurans; Cell Cycle; DNA, Neoplasm; Flavonoids; G2 Phase; Humans; Indicators and Reagents; K562 Cells; Mitosis; Models, Molecular; Molecular Conformation; Protein Binding; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Tubulin; Uvaria | 2003 |
Additivity of molecular fields: CoMFA study on dual activators of PPARalpha and PPARgamma.
Topics: Benzofurans; Binding Sites; Drug Design; Ligands; Models, Molecular; Oxadiazoles; Oxazines; PPAR alpha; PPAR gamma; Protein Binding; Quantitative Structure-Activity Relationship; Thiazoles | 2005 |
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.
Topics: Animals; Benzofurans; Binding, Competitive; Brain; Carbolines; Cerebral Cortex; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Harmine; Hippocampus; Imidazoles; Imidazoline Receptors; Liver; Male; Monoamine Oxidase; Morphine; Morphine Dependence; Naloxone; Norepinephrine; Picolinic Acids; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Substance Withdrawal Syndrome; Thiazoles; Tritium; Tyrosine 3-Monooxygenase | 2005 |
Characterisation of imidazoline I2 binding sites in pig brain.
Topics: Animals; Benzofurans; Binding Sites; Binding, Competitive; Brain; Carbolines; Clonidine; Dose-Response Relationship, Drug; Female; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Male; Monoamine Oxidase Inhibitors; Picolinic Acids; Radioligand Assay; Receptors, Drug; Swine; Thiazoles; Tritium | 2005 |
Autoradiographical distribution of imidazoline binding sites in monoamine oxidase A deficient mice.
Topics: Animals; Autoradiography; Benzofurans; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Epithelial Cells; Harmine; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Iodine Radioisotopes; Kidney; Mice; Mice, Inbred C3H; Mice, Knockout; Monoamine Oxidase; Neurons; Picolinic Acids; Radioligand Assay; Receptors, Drug; Thiazoles | 2006 |
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Topics: Animals; Benzofurans; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Humans; Indoles; Inhibitory Concentration 50; Ligands; Models, Chemical; PPAR delta; Structure-Activity Relationship; Thiazoles; Thiophenes | 2007 |
Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B.
Topics: Antioxidants; Ascorbic Acid; Benzofurans; Benzothiazoles; Biphenyl Compounds; Cell Survival; Chelating Agents; Endothelial Cells; Ferrous Compounds; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydroxyl Radical; Lactates; Oxidants; Picrates; Plant Roots; Salvia; Sulfonic Acids; Tetrazolium Salts; Thiazoles | 2008 |
Studies on the synthesis and reactivity of novel benzofuran-2-yl-[3-methyl-3-phenylcyclobutyl] methanones and their antimicrobial activity.
Topics: Anti-Infective Agents; Benzofurans; Cyclobutanes; DNA Damage; Lignans; Models, Molecular; Molecular Structure; Oximes; Structure-Activity Relationship; Thiazoles; Thiosemicarbazones; Ultraviolet Rays | 2005 |
Inhibitory effects of salvianolic acid B on the high glucose-induced mesangial proliferation via NF-kappaB-dependent pathway.
Topics: Antioxidants; Benzofurans; Blotting, Western; Cell Cycle; Cell Nucleus; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Fibronectins; Flow Cytometry; Glucose; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mesangial Cells; NF-kappa B; Signal Transduction; Tetrazolium Salts; Thiazoles | 2008 |
Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells.
Topics: Animals; Antineoplastic Agents; Benzofurans; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Pancreatic Neoplasms; Receptors, Leukotriene B4; Thiazoles | 2008 |
The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Benzofurans; Benzoxazoles; Benzylamines; Blood Glucose; Clozapine; Corticosterone; Cyclopentanes; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Olanzapine; Piperazines; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Thiazoles | 2008 |
Dimethoxyaurones: Potent inhibitors of ABCG2 (breast cancer resistance protein).
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzofurans; Blotting, Western; Breast Neoplasms; Cell Proliferation; Cell Survival; Crystallography, X-Ray; DNA, Complementary; Dogs; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluoresceins; Humans; Indicators and Reagents; Mitoxantrone; Models, Molecular; Neoplasm Proteins; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2008 |
Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Benzothiazoles; Benzoxazoles; Chemistry, Pharmaceutical; Curcumin; Drug Design; Electrons; Humans; Inhibitory Concentration 50; Models, Chemical; Peptide Fragments; Structure-Activity Relationship; Styrenes; Thiazoles | 2008 |
Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Benzofurans; Cell Line; Cell Proliferation; Circular Dichroism; Electrophoretic Mobility Shift Assay; Fibroblasts; Gene Knockout Techniques; HL-60 Cells; HMGA1b Protein; Humans; Models, Molecular; Protein Binding; Protein Multimerization; Proto-Oncogene Proteins c-myc; Pyridines; Pyrrolidines; Rats; Thiazoles | 2009 |
Anti-cancer effects of a novel compound HS-113 on cell growth, apoptosis, and angiogenesis in human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzofurans; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Liver Neoplasms; Neovascularization, Pathologic; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Umbilical Veins | 2011 |
Aryl hydrocarbon receptor-dependent induction of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in cerebellar granule cells from mouse.
Topics: Animals; Apoptosis; Benzofurans; Caspase 3; Cells, Cultured; Cerebellum; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Environmental Pollutants; Indoles; Mice; Mice, Knockout; Neurons; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Tetrazolium Salts; Thiazoles; Trypan Blue | 2011 |
Polybrominated diphenyl ethers and polychlorinated dibenzo-p-dioxins and dibenzofurans in surface dust at an E-waste processing site in Southeast China.
Topics: Analysis of Variance; Benzofurans; Biological Assay; China; Computers; Cytochrome P-450 CYP1A1; Dioxins; Dust; Environmental Pollutants; Halogenated Diphenyl Ethers; Refuse Disposal; Tetrazolium Salts; Thiazoles; Toxicity Tests | 2011 |
In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.
Topics: Abietanes; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Benzofurans; Calcium; Cell Survival; Cholinesterase Inhibitors; Hydroxybenzoates; L-Lactate Dehydrogenase; Male; Neuroprotective Agents; PC12 Cells; Phosphatidylinositols; Plant Extracts; Polyphenols; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Tetrazolium Salts; Thiazoles | 2011 |
Exposure to dibenzofuran triggers autophagy in lung cells.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Autophagy; Benzofurans; Blotting, Western; Cell Death; Cell Line; Cell Nucleus; Cell Proliferation; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Energy Metabolism; Environmental Pollutants; Humans; L-Lactate Dehydrogenase; Lung; Lysosomes; Membrane Potential, Mitochondrial; Mice; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2012 |
New drugs 2012 part I.
Topics: Aminopyridines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzamides; Benzazepines; Benzimidazoles; Benzofurans; Ceftaroline; Cephalosporins; Cyclopropanes; Drug Approval; Drug Combinations; Humans; Imidazoles; Indoles; Isoindoles; Linagliptin; Lurasidone Hydrochloride; Macrolides; Oxadiazoles; Piperazines; Proline; Purines; Quinazolines; Thiazoles; United States; Vilazodone Hydrochloride | 2012 |
The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells.
Topics: Angiogenesis Inhibitors; Apoptosis; Benzofurans; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Human Umbilical Vein Endothelial Cells; Humans; In Situ Nick-End Labeling; Liver Neoplasms; Molecular Structure; Neovascularization, Pathologic; Thiazoles; Wound Healing | 2012 |
Inhibitors of translation targeting eukaryotic translation initiation factor 4A.
Topics: Animals; Anthracenes; Benzofurans; Epoxy Compounds; Eukaryotic Initiation Factor-4A; Humans; Macrolides; Perylene; Protein Kinase Inhibitors; Sterols; Thiazoles | 2012 |
Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptor antagonists.
Topics: Acetamides; Animals; Benzofurans; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dioxanes; Humans; Isoquinolines; Kinetics; Orexin Receptors; Phenylurea Compounds; Piperidines; Protein Binding; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Thiazoles | 2012 |
A new isobenzofuranone from the mangrove endophytic fungus Penicillium sp. (ZH58).
Topics: Benzofurans; Cell Line; China; Complex Mixtures; Fermentation; Humans; Inhibitory Concentration 50; Molecular Structure; Penicillium; Rhizophoraceae; Tetrazolium Salts; Thiazoles | 2013 |
Synthesis, radiolabeling, and in vivo pharmacokinetic evaluation of the amyloid beta radioligand [11C]AZD4694 in nonhuman primates.
Topics: Amyloid beta-Peptides; Aniline Compounds; Animals; Benzofurans; Brain; Carbon Radioisotopes; Humans; Hydrocarbons, Fluorinated; Macaca fascicularis; Magnetic Resonance Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Time Factors | 2014 |
Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Azo Compounds; Benzofurans; Blotting, Western; Cell Differentiation; Coloring Agents; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Freeze Drying; Mice; Phaeophyceae; Real-Time Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles | 2013 |
Synthesis of benzofuro[6,7-d]thiazoles, benzofuro[7,6-d]thiazoles and 6-arylaminobenzo[d]thiazole-4,7-diones as antifungal agent.
Topics: Antifungal Agents; Aspergillus; Benzofurans; Candida; Cryptococcus neoformans; Microbial Sensitivity Tests; Thiazoles | 2014 |
In vitro antimicrobial activities of 1-methoxyficifolinol, licorisoflavan A, and 6,8-diprenylgenistein against Streptococcus mutans.
Topics: Anti-Infective Agents; Anti-Infective Agents, Local; Benzofurans; Benzopyrans; Biofilms; Chlorhexidine; Fibroblasts; Flavonoids; Genistein; Gentian Violet; Gingiva; Glycyrrhiza uralensis; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microscopy, Confocal; Plant Extracts; Plant Roots; Streptococcus mutans; Streptococcus sobrinus; Tetrazolium Salts; Thiazoles | 2015 |
Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzofurans; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Dynamics Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles; Torpedo; Urea | 2015 |
Standardized Expression of 18F-NAV4694 and 11C-PiB β-Amyloid PET Results with the Centiloid Scale.
Topics: Adult; Amyloid beta-Peptides; Aniline Compounds; Benzofurans; Benzothiazoles; Brain; Female; Fluorine Radioisotopes; Humans; Hydrocarbons, Fluorinated; Image Interpretation, Computer-Assisted; Male; Molecular Imaging; Positron-Emission Tomography; Practice Guidelines as Topic; Protein Interaction Mapping; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Tissue Distribution | 2016 |
Dibenzofuran, dibenzothiophene and N-methyl carbazole tethered 2-aminothiazoles and their cinnamamides as potent inhibitors of Mycobacterium tuberculosis.
Topics: Anti-Bacterial Agents; Benzofurans; Carbazoles; Cell Survival; Cinnamates; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazoles; Thiophenes | 2018 |
Proapoptotic effects of novel thiazole derivative on human glioma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzofurans; Brain Neoplasms; Cell Line, Tumor; DNA Damage; Doxorubicin; Glioblastoma; Humans; Inhibitory Concentration 50; Intercalating Agents; Reactive Oxygen Species; Temozolomide; Thiazoles | 2019 |
Synthesis and biological evaluation of BMS-986120 and its deuterated derivatives as PAR4 antagonists.
Topics: Animals; Benzofurans; Blood Platelets; Deuterium; Drug Stability; Humans; Imidazoles; Male; Mice, Inbred ICR; Microsomes, Liver; Morpholines; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Thiazoles | 2019 |
Overactive bladder - pharmacological treatment.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Antidepressive Agents; Benzilates; Benzofurans; Brazil; Clinical Decision-Making; Drug Therapy, Combination; Humans; Mandelic Acids; Muscarinic Antagonists; Nortropanes; Pyrrolidines; Solifenacin Succinate; Thiazoles; Tolterodine Tartrate; Urinary Bladder, Overactive | 2019 |
A Nordic registry-based study of drug treatment patterns in overactive bladder patients.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Aged; Aged, 80 and over; Benzhydryl Compounds; Benzofurans; Denmark; Female; Humans; Male; Mandelic Acids; Middle Aged; Muscarinic Antagonists; Norway; Practice Patterns, Physicians'; Prospective Studies; Pyrrolidines; Registries; Solifenacin Succinate; Sweden; Thiazoles; Tolterodine Tartrate; Urinary Bladder, Overactive | 2019 |
New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.
Topics: Benzofurans; Cell Survival; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Conformation; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Structure-Activity Relationship; Thiazoles | 2019 |
A comparative study of small molecules targeting eIF4A.
Topics: Antineoplastic Agents; Benzofurans; Cell Proliferation; Cell Survival; Epoxy Compounds; Eukaryotic Initiation Factor-4A; Eukaryotic Initiation Factor-4F; Humans; Macrolides; Neoplasms; Phosphatidylinositol 3-Kinases; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Small Molecule Libraries; Sterols; Thiazoles; TOR Serine-Threonine Kinases | 2020 |
Heterocycles 51: Liphophilicity investigation of some thiazole chalcones and aurones by experimental and theoretical methods.
Topics: Benzofurans; Cell Line, Tumor; Chalcones; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Humans; Hydrophobic and Hydrophilic Interactions; Software; Thiazoles | 2020 |
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
Topics: Benzofurans; Blood Platelets; Humans; Imidazoles; Morpholines; Platelet Aggregation; Receptor, PAR-1; Receptors, Thrombin; Thiazoles; Thrombin; Thrombosis | 2022 |
Rational synthesis, anticancer activity, and molecular docking studies of novel benzofuran liked thiazole hybrids.
Topics: Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles | 2023 |