Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and bay 57-1293

thiazoles has been researched along with bay 57-1293 in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (43.75)29.6817
2010's16 (50.00)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Bach, U; Baumeister, J; Bender, W; Betz, UA; Eckenberg, P; Fischer, R; Frappa, I; Haebich, D; Handke, G; Hendrix, M; Henninger, K; Hewlett, G; Jensen, A; Keldenich, J; Kleymann, G; Kolb, J; Lockhoff, O; Mäben, J; Pevzner, V; Popp, A; Rübsamen-Waigmann, H; Schneider, U; Weber, O1
Betz, UA; Fischer, R; Hendrix, M; Kleymann, G; Rübsamen-Waigmann, H1
Hallenberger, S1
Kleymann, G1
Biswas, S; Field, HJ; Jennens, L2
Biswas, S; Field, HJ; Swift, M1
Baumeister, J; Eckenberg, P; Fischer, R; Henninger, K; Kleymann, G; Ruebsamen-Waigmann, H1
Biswas, S; Field, HJ; Smith, C1
Atwal, E; Gebhardt, BM; Kaufman, HE; Kleymann, G; Rübsamen-Waigmann, H; Thompson, HW; Varnell, ED1
Aguirre-Hernández, J; Biswas, S; Field, HJ; Kleymann, G; Lyall, J; Swift, M; Tiley, LS1
Birkmann, A; Biswas, S; Field, HJ; Tiley, LS; Zimmermann, H1
Biswas, S; Field, HJ1
Biswas, S; Field, HJ; Miguel, RN; Sukla, S1
Frost, AL; Itzhaki, RF; Wozniak, MA1
Birkmann, A; Field, HJ; Huang, ML; Lay, EM; Mickleburgh, I; Zimmermann, H1
Biswas, S; Field, HJ; Sukla, S1
Birkmann, A; Corey, L; Fife, K; Galitz, L; Huang, ML; Johnston, C; Kriesel, J; Magaret, A; Ruebsamen-Schaeff, H; Selke, S; Stobernack, HP; Stoelben, S; Timmler, B; Tyring, S; Wald, A; Warren, T1
Prichard, M; Whitley, RJ1
Birkmann, A; Biswas, S; Field, HJ; Goldner, T; Kropeit, D; Paulsen, D; Ruebsamen-Schaeff, H; Sukla, S; Welbers, A; Zimmermann, H1
Acosta, EP; James, SH; Larson, KB; Prichard, MN1
Agut, H; Boutolleau, D; Brunet, C; Burrel, S; Collot, M; Rouard, C1
Birkmann, A; Corey, L; Magaret, A; Melhem, MR; Ossig, J; Rubino, CM; Ruebsamen-Schaeff, H; Schiffer, JT; Stoelben, S; Swan, DA; Timmler, B; Van Wart, SA; Wald, A; Zimmermann, H1
Birkmann, A; Zimmermann, H1
Birkmann, A; Corey, L; Diem, K; Edlefsen, PT; Goldner, T; Huang, ML; Kee, JJ; Magaret, CA; Ruebsamen-Schaeff, H; Stoelben, S; Timmler, B; Wald, A; Warren, T; Zimmermann, H1
Birkmann, A; Corey, L; Fife, K; Huang, ML; Johnston, C; Magaret, A; Ruebsamen-Schaeff, H; Selke, S; Stobernack, HP; Timmler, B; Tyring, S; Wald, A; Warren, T; Zimmermann, H1
Birkmann, A; Bonsmann, S; Collins, DJ; Goldner, T; Pfaff, T; Prichard, MN; Quenelle, DC; Rice, TL; Zimmermann, H1
Shiraki, K1
Byrne, CM; Coombs, D; Gantt, S1
Elbe-Bürger, A; Matiasek, J; Mildner, M; Popow-Kraupp, T; Schmidt, R; Schuster, C; Tajpara, P; Vierhapper, M1
Cannon, L; Farooq, H; Kingston, M; Tholouli, E; Ward, C1
Abid, H; Boutolleau, D; Burrel, S; Fourgeaud, J; Frange, P; Lanternier, F; Loiseau, C; Pouvaret, A; Rouzaud, C; Serris, A1

Reviews

6 review(s) available for thiazoles and bay 57-1293

ArticleYear
Helicase primase: targeting the Achilles heel of herpes simplex viruses.
    Antiviral chemistry & chemotherapy, 2004, Volume: 15, Issue:3

    Topics: Antiviral Agents; DNA Helicases; DNA Primase; Enzyme Inhibitors; Herpes Simplex; Humans; Models, Molecular; Pyridines; Simplexvirus; Sulfonamides; Thiazoles; Viral Proteins

2004
Herpes simplex virus helicase-primase inhibitors: recent findings from the study of drug resistance mutations.
    Antiviral chemistry & chemotherapy, 2008, Volume: 19, Issue:1

    Topics: Antiviral Agents; DNA Helicases; DNA Primase; Drug Resistance, Viral; Herpesvirus 1, Human; Humans; Point Mutation; Pyridines; Sulfonamides; Thiazoles; Viral Proteins

2008
Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections.
    Future medicinal chemistry, 2014, Volume: 6, Issue:1

    Topics: Antiviral Agents; DNA Helicases; DNA Primase; DNA Replication; Herpes Simplex; Humans; Oxadiazoles; Pyridines; Simplexvirus; Sulfonamides; Thiazoles; Viral Proteins

2014
Helicase-primase as a target of new therapies for herpes simplex virus infections.
    Clinical pharmacology and therapeutics, 2015, Volume: 97, Issue:1

    Topics: Acyclovir; Animals; Antiviral Agents; DNA Helicases; DNA Primase; Drug Design; Drug Resistance, Viral; Herpes Simplex; Humans; Molecular Targeted Therapy; Oxadiazoles; Pyridines; Sulfonamides; Thiazoles; Viral Proteins

2015
HSV antivirals - current and future treatment options.
    Current opinion in virology, 2016, Volume: 18

    Topics: Acyclovir; Antiviral Agents; Clinical Trials, Phase II as Topic; DNA Helicases; DNA Primase; Drug Resistance, Viral; Herpes Genitalis; Herpes Simplex; Herpes Simplex Virus Vaccines; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Oxadiazoles; Pyridines; Sulfonamides; Thiazoles; Viral Proteins

2016
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
    Drugs of today (Barcelona, Spain : 1998), 2017, Volume: 53, Issue:11

    Topics: Animals; Antiviral Agents; DNA Helicases; DNA Primase; Drug Resistance, Viral; Herpes Zoster; Herpesvirus 3, Human; Humans; Oxadiazoles; Pyridines; Sulfonamides; Thiazoles; Viral Proteins

2017

Trials

3 trial(s) available for thiazoles and bay 57-1293

ArticleYear
Helicase-primase inhibitor pritelivir for HSV-2 infection.
    The New England journal of medicine, 2014, Jan-16, Volume: 370, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Male; Middle Aged; Polymerase Chain Reaction; Pyridines; Sulfonamides; Thiazoles; Viral Load; Virus Shedding

2014
No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy.
    The Journal of infectious diseases, 2016, 07-15, Volume: 214, Issue:2

    Topics: Antiviral Agents; Drug Resistance, Viral; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Male; Mutation; Pyridines; Sequence Analysis, DNA; Sulfonamides; Thiazoles; Viral Proteins

2016
Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
    JAMA, 2016, 12-20, Volume: 316, Issue:23

    Topics: Acyclovir; Adult; Aged; Antiviral Agents; Cross-Over Studies; Double-Blind Method; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Male; Middle Aged; Pyridines; Recurrence; Sulfonamides; Thiazoles; Valacyclovir; Valine; Virus Shedding; Young Adult

2016

Other Studies

23 other study(ies) available for thiazoles and bay 57-1293

ArticleYear
New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease.
    Nature medicine, 2002, Volume: 8, Issue:4

    Topics: Acyclovir; Animals; Antiviral Agents; DNA Helicases; DNA Primase; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Guinea Pigs; Herpes Simplex; Humans; Infant, Newborn; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pregnancy; Pyridines; Safety; Sulfonamides; Thiazoles; Viral Proteins

2002
Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:6

    Topics: Animals; Antibodies, Viral; Antiviral Agents; Blotting, Southern; DNA Helicases; DNA Primase; Drug Resistance, Microbial; Eye; Female; Herpes Simplex; Mice; Mice, Inbred BALB C; Mucous Membrane; Pyridines; Rats; Rats, Inbred Lew; Simplexvirus; Skin; Sulfonamides; Thiazoles

2002
Antiviral therapies.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2004, Volume: 30 Suppl 1

    Topics: Animals; Anti-HIV Agents; Antiviral Agents; Cytomegalovirus Infections; Drug Evaluation, Preclinical; Hepatitis B; Herpes Simplex; HIV Infections; Humans; Mice; Naphthalenesulfonates; Pyridines; Pyrimidines; Sulfonamides; Thiazoles; Virus Diseases

2004
The helicase primase inhibitor, BAY 57-1293 shows potent therapeutic antiviral activity superior to famciclovir in BALB/c mice infected with herpes simplex virus type 1.
    Antiviral research, 2007, Volume: 75, Issue:1

    Topics: 2-Aminopurine; Administration, Oral; Animals; Antiviral Agents; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ear; Famciclovir; Herpes Simplex; Herpesvirus 1, Human; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Pyridines; Skin; Sulfonamides; Thiazoles

2007
High frequency of spontaneous helicase-primase inhibitor (BAY 57-1293) drug-resistant variants in certain laboratory isolates of HSV-1.
    Antiviral chemistry & chemotherapy, 2007, Volume: 18, Issue:1

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; DNA Helicases; DNA Primase; Enzyme Inhibitors; Herpesvirus 1, Human; Pyridines; Sulfonamides; Thiazoles; Vero Cells

2007
Superior efficacy of helicase-primase inhibitor BAY 57-1293 for herpes infection and latency in the guinea pig model of human genital herpes disease.
    Antiviral chemistry & chemotherapy, 2007, Volume: 18, Issue:1

    Topics: Animals; Antiviral Agents; Disease Models, Animal; DNA Helicases; DNA Primase; DNA, Viral; Enzyme Inhibitors; Guinea Pigs; Herpes Genitalis; Herpesvirus 2, Human; Humans; Polymerase Chain Reaction; Pyridines; Sulfonamides; Thiazoles

2007
Single amino acid substitutions in the HSV-1 helicase protein that confer resistance to the helicase-primase inhibitor BAY 57-1293 are associated with increased or decreased virus growth characteristics in tissue culture.
    Archives of virology, 2007, Volume: 152, Issue:8

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antiviral Agents; Chlorocebus aethiops; DNA Helicases; DNA Primase; Drug Resistance, Viral; Enzyme Inhibitors; Female; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Pyridines; Sulfonamides; Thiazoles; Vero Cells; Viral Proteins; Virus Replication

2007
Detection of HSV-1 variants highly resistant to the helicase-primase inhibitor BAY 57-1293 at high frequency in 2 of 10 recent clinical isolates of HSV-1.
    The Journal of antimicrobial chemotherapy, 2007, Volume: 60, Issue:2

    Topics: Adult; Amino Acid Sequence; Animals; Chlorocebus aethiops; DNA Helicases; Drug Resistance, Viral; Enzyme Inhibitors; Female; Genes, Viral; Herpes Simplex; Herpesvirus 1, Human; Humans; Male; Molecular Sequence Data; Polymorphism, Genetic; Pyridines; Sulfonamides; Thiazoles; Vero Cells; Viral Plaque Assay

2007
Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2008, Volume: 24, Issue:1

    Topics: Animals; DNA Helicases; DNA Primase; DNA, Viral; Enzyme Inhibitors; Female; Heat Stress Disorders; Herpesvirus 1, Human; Keratitis, Herpetic; Mice; Mice, Inbred BALB C; Pyridines; Rabbits; Sulfonamides; Tears; Thiazoles; Trigeminal Ganglion; Viral Proteins; Virus Shedding

2008
A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 61, Issue:5

    Topics: Antiviral Agents; DNA Helicases; DNA Primase; Dose-Response Relationship, Drug; Drug Resistance, Viral; Herpesvirus 1, Human; Pyridines; Sulfonamides; Thiazoles; Viral Proteins

2008
Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity.
    Antiviral research, 2008, Volume: 80, Issue:1

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; DNA Helicases; DNA Primase; Drug Resistance, Viral; Enzyme Inhibitors; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice; Mice, Inbred BALB C; Mutation; Pyridines; Sulfonamides; Thiazoles; Vero Cells; Viral Proteins; Virulence

2008
A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure.
    The Journal of general virology, 2009, Volume: 90, Issue:Pt 8

    Topics: Amino Acid Substitution; Animals; Antiviral Agents; DNA Helicases; DNA Primase; Drug Resistance, Viral; Herpesvirus 1, Human; Mice; Models, Molecular; Mutation, Missense; Pyridines; Sulfonamides; Thiazoles; Viral Proteins; Virulence; Virulence Factors

2009
The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1.
    Antiviral research, 2013, Volume: 99, Issue:3

    Topics: Acyclovir; Alzheimer Disease; Amyloid beta-Peptides; Antiviral Agents; DNA Helicases; DNA Primase; Down-Regulation; Enzyme Inhibitors; Herpes Simplex; Herpesvirus 1, Human; Humans; Pyridines; Sulfonamides; tau Proteins; Thiazoles; Viral Proteins; Virus Replication

2013
Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase-primase inhibitor pritelivir.
    Antiviral research, 2013, Volume: 100, Issue:2

    Topics: Acyclovir; Antiviral Agents; DNA Helicases; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Microbial Sensitivity Tests; Pyridines; Sulfonamides; Thiazoles; United States; Viral Plaque Assay

2013
A novel potential therapy for HSV.
    The New England journal of medicine, 2014, Jan-16, Volume: 370, Issue:3

    Topics: Antiviral Agents; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Male; Pyridines; Sulfonamides; Thiazoles; Virus Shedding

2014
Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7

    Topics: Animals; Antiviral Agents; DNA Primase; DnaB Helicases; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Herpes Simplex; Herpesvirus 1, Human; Male; Mice; Mice, Inbred BALB C; Pyridines; Skin Diseases, Viral; Sulfonamides; Thiazoles; Viral Plaque Assay; Virus Replication

2014
High conservation of herpes simplex virus UL5/UL52 helicase-primase complex in the era of new antiviral therapies.
    Antiviral research, 2016, Volume: 128

    Topics: Acyclovir; Antiviral Agents; DNA Helicases; DNA Primase; Drug Resistance, Viral; Herpesvirus 2, Human; Humans; Immunocompromised Host; Oxadiazoles; Polymorphism, Genetic; Pyridines; Simplexvirus; Sulfonamides; Thiazoles; Viral Proteins

2016
Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes.
    Science translational medicine, 2016, Feb-03, Volume: 8, Issue:324

    Topics: Antiviral Agents; Clinical Trials as Topic; Computer Simulation; Dose-Response Relationship, Drug; Herpesvirus 2, Human; Humans; Kinetics; Models, Biological; Pyridines; Sulfonamides; Thiazoles; Treatment Outcome; Virus Shedding

2016
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.
    Antiviral research, 2018, Volume: 149

    Topics: Acyclovir; Animals; Antiviral Agents; Disease Models, Animal; Drug Therapy, Combination; Encephalitis, Herpes Simplex; Female; Humans; Mice; Pyridines; Sulfonamides; Thiazoles; Tissue Distribution; Treatment Outcome

2018
Effects of spatiotemporal HSV-2 lesion dynamics and antiviral treatment on the risk of HIV-1 acquisition.
    PLoS computational biology, 2018, Volume: 14, Issue:4

    Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Computational Biology; Computer Simulation; Female; Genitalia, Female; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; HIV-1; Humans; Immunity, Mucosal; Models, Biological; Pyridines; Risk Factors; Sexual Behavior; Stochastic Processes; Sulfonamides; Thiazoles

2018
A Preclinical Model for Studying Herpes Simplex Virus Infection.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:3

    Topics: Acyclovir; Adult; Aged; Antiviral Agents; Biopsy, Needle; Case-Control Studies; Female; Herpes Simplex; Herpesvirus 1, Human; Humans; Immunohistochemistry; In Vitro Techniques; Male; Middle Aged; Models, Biological; Pyridines; Reference Values; Statistics, Nonparametric; Sulfonamides; Thiazoles; Virus Replication; Young Adult

2019
Use of pritelivir in refractory aciclovir-resistant herpes simplex virus type 2.
    International journal of STD & AIDS, 2021, Volume: 32, Issue:10

    Topics: Acyclovir; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Herpes Simplex; Herpesvirus 2, Human; Humans; Pyridines; Sulfonamides; Thiazoles

2021
Pritelivir for recurrent aciclovir-resistant herpes simplex virus 2 infections in immunocompromised patients.
    The Journal of antimicrobial chemotherapy, 2022, 07-28, Volume: 77, Issue:8

    Topics: Acyclovir; Antiviral Agents; Herpes Genitalis; Herpesvirus 2, Human; Humans; Immunocompromised Host; Sulfonamides; Thiazoles

2022