thiazoles has been researched along with az 11645373 in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alcaraz, L; Bent, J; Bowers, K; Braddock, M; Fagura, M; Furber, M; Jiang, LH; Laurent, C; Lawson, M; Mortimore, M; Stokes, L; Surprenant, A; Theaker, J | 1 |
| Clay, WC; Dean, DK; Michel, AD; Ng, SW; Roman, S; Walter, DS | 1 |
| Braddock, M; Clifton, AD; Lopez-Castejon, G; Pelegrin, P; Surprenant, A; Theaker, J | 1 |
| Bradley, HJ; Browne, LE; Jiang, LH; Yang, W | 1 |
| Hanamsagar, R; Kielian, T; Torres, V | 1 |
| Grden, M; Kocbuch, K; Maciejewska, I; Pawelczyk, T; Sakowicz-Burkiewicz, M; Szutowicz, A | 1 |
| Bartlett, R; Sluyter, R; Yerbury, JJ | 1 |
| Bochkov, VN; Godschachner, V; Oskolkova, OV | 1 |
| Talbot, P; Weng, NJ | 1 |
| Bin Dayel, A; Evans, RJ; Schmid, R | 1 |
| Drummond, GR; Kirby, FJ; Lawlor, KE; Mansell, A; Rainczuk, K; Rosli, S; Tate, MD | 1 |
11 other study(ies) available for thiazoles and az 11645373
| Article | Year |
|---|---|
Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.
Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Anti-Inflammatory Agents; Benzoxazoles; Calcium Signaling; Cell Line; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Imides; Interleukin-1beta; Ion Channel Gating; Lipopolysaccharides; Membrane Potentials; Monocytes; Patch-Clamp Techniques; Purinergic P2 Receptor Antagonists; Quinolinium Compounds; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Species Specificity; Thiazoles; Transfection; Xanthenes | 2006 |
Mechanism of action of species-selective P2X(7) receptor antagonists.
Topics: Adamantane; Adenosine Triphosphate; Animals; Azabicyclo Compounds; Binding Sites; Cell Line, Tumor; Dogs; Dose-Response Relationship, Drug; Glycine; Guinea Pigs; Humans; Mice; Piperazines; Protein Conformation; Purinergic P2 Receptor Antagonists; Radioligand Assay; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Recombinant Fusion Proteins; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Temperature; Thiazoles; Transduction, Genetic; Vanadates | 2009 |
P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Cathepsin B; Cathepsins; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Interleukin-1beta; Joint Diseases; L Cells; Macrophages; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Receptors, Tumor Necrosis Factor; Thiazoles | 2010 |
Pharmacological properties of the rhesus macaque monkey P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Benzoxazoles; HEK293 Cells; Humans; Macaca mulatta; Membrane Potentials; Molecular Sequence Data; Patch-Clamp Techniques; Purinergic P2X Receptor Agonists; Purinergic P2X Receptor Antagonists; Pyridines; Quinolinium Compounds; Receptors, Purinergic P2X7; Single-Cell Analysis; Tetrazoles; Thiazoles | 2011 |
Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Bacterial Proteins; Bacterial Toxins; CARD Signaling Adaptor Proteins; Carrier Proteins; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hemolysin Proteins; Interleukin-18; Interleukin-1beta; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Models, Biological; NLR Family, Pyrin Domain-Containing 3 Protein; Purinergic P2 Receptor Antagonists; Signal Transduction; Staphylococcus aureus; Thiazoles; Time Factors | 2011 |
High glucose concentration impairs ATP outflow and immunoglobulin production by human peripheral B lymphocytes: involvement of P2X7 receptor.
Topics: Adenosine Triphosphate; Antibody Formation; B-Lymphocytes; Cells, Cultured; Diabetes Complications; Female; Glucose; Humans; Hyperglycemia; Immunity, Humoral; Immunoglobulin M; Infections; Male; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; Staphylococcus aureus; Thiazoles | 2013 |
P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia.
Topics: Animals; Cell Death; Cell Line; Immunoblotting; Mice; Microglia; Purinergic P2X Receptor Antagonists; Pyridines; Reactive Oxygen Species; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles; Thiazoles | 2013 |
Off-Target Anti-Inflammatory Activity of the P2X7 Receptor Antagonist AZ11645373.
Topics: Anti-Inflammatory Agents; Human Umbilical Vein Endothelial Cells; Humans; Inflammasomes; Interleukin-8; Phosphatidylcholines; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; RNA, Messenger; Thiazoles; Transcriptional Activation | 2017 |
The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Biomarkers; Calcium; Cell Adhesion; Cell Differentiation; Cell Surface Extensions; Extracellular Space; Gene Knockdown Techniques; Human Embryonic Stem Cells; Humans; Ion Channel Gating; Models, Biological; Purinergic P2X Receptor Antagonists; rac GTP-Binding Proteins; Receptors, Purinergic P2X7; rho GTP-Binding Proteins; Thiazoles; Time-Lapse Imaging | 2017 |
Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Allosteric Site; Amides; Binding Sites; Humans; Imidazoles; Indoles; Models, Molecular; Molecular Docking Simulation; Point Mutation; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; Rosaniline Dyes; Thiazoles | 2019 |
Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection.
Topics: Animals; Cells, Cultured; Drug Repositioning; Female; Inflammasomes; Inflammation; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Orthomyxoviridae Infections; Probenecid; Receptors, Purinergic P2X7; Thiazoles | 2019 |