Compounds > thiazoles
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thiazoles and archazolid b

thiazoles has been researched along with archazolid b in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (35.71)29.6817
2010's8 (57.14)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Carlomagno, T; Farès, C; Hassfeld, J; Menche, D; Steinmetz, H1
Hassfeld, J; Huss, M; Menche, D; Sasse, F; Wieczorek, H1
Chen, IT; Roethle, PA; Trauner, D1
Hattori, H; Huang, Z; Mohan, S; Negishi, E; Wang, C; Wang, G1
Hassfeld, J; Li, J; Mayer, K; Menche, D; Rudolph, S1
Bittner, T; Brouwers, N; Capell, A; Carlson, AM; Cruts, M; Dormann, D; Fellerer, K; Gijselinck, I; Haass, C; Herms, J; Jansen, R; Kunze, B; Lammich, S; Liebscher, S; Sasse, F; Sleegers, K; Steinmetz, H; Van Broeckhoven, C; Willem, M1
Bockelmann, S; Essig, S; Horstmann, N; Huss, M; Menche, D; Sasse, F; Wieczorek, H1
Ashcraft, B; Doucette, R; Havko, N; Melly, GC; O'Neil, GW; Sebren, LJ; Tran, AB; Young, JC1
Arnold, GJ; Fröhlich, T; Kubisch, R; Roidl, A; Schreiner, L; Vollmar, AM; von Schwarzenberg, K; Wagner, E1
Chen, YR; Efferth, T; Hamm, R; Müller, R; Seo, EJ; Wu, CF; Yang, NS; Zeino, M1
Efferth, T; Hamm, R; Steinmetz, H; Sugimoto, Y1
Efferth, T; Frewert, S; Hamm, R; Zeino, M1
Gerstmeier, J; Menche, D; Mosig, A; Müller, R; Pergola, C; Raasch, M; Rao, Z; Rummler, S; Thomas, L; Weinigel, C; Werz, O1
Abdelrahman, A; Ennenbach, C; Gütschow, M; Lemke, C; Menche, D; Müller, CE; Rivière, S; Vielmuth, C1

Other Studies

14 other study(ies) available for thiazoles and archazolid b

ArticleYear
Stereochemical determination of Archazolid A and B, highly potent vacuolar-type ATPase inhibitors from the Myxobacterium Archangium gephyra.
    Organic letters, 2006, Oct-12, Volume: 8, Issue:21

    Topics: Antimitotic Agents; Macrolides; Molecular Structure; Myxococcales; Stereoisomerism; Thiazoles; Vacuolar Proton-Translocating ATPases

2006
Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor.
    Bioorganic & medicinal chemistry letters, 2007, Mar-15, Volume: 17, Issue:6

    Topics: Animals; Antimitotic Agents; Cell Line; Drug Design; Enzyme Inhibitors; Indicators and Reagents; Macrolides; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; Myxococcales; Structure-Activity Relationship; Thiazoles; Vacuolar Proton-Translocating ATPases

2007
Total synthesis of (-)-archazolid B.
    Journal of the American Chemical Society, 2007, Jul-25, Volume: 129, Issue:29

    Topics: Catalysis; Indicators and Reagents; Macrolides; Myxococcales; Ruthenium; Stereoisomerism; Thiazoles

2007
Recent advances in efficient and selective synthesis of di-, tri-, and tetrasubstituted alkenes via Pd-catalyzed alkenylation-carbonyl olefination synergy.
    Accounts of chemical research, 2008, Nov-18, Volume: 41, Issue:11

    Topics: Alkenes; Carbonic Acid; Catalysis; Fatty Acids, Unsaturated; Lactones; Macrolides; Molecular Structure; Palladium; Pyrones; Stereoisomerism; Thiazoles

2008
Modular total synthesis of archazolid A and B.
    The Journal of organic chemistry, 2009, Oct-02, Volume: 74, Issue:19

    Topics: Macrolides; Molecular Conformation; Stereoisomerism; Thiazoles; Vacuolar Proton-Translocating ATPases

2009
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Feb-02, Volume: 31, Issue:5

    Topics: Alkalies; Amiodarone; Animals; Animals, Newborn; Autophagy-Related Protein 5; Bepridil; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chloroquine; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Frontotemporal Lobar Degeneration; Granulins; HEK293 Cells; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Macrolides; Male; Mice; Microtubule-Associated Proteins; Mutation; Neurons; Progranulins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Vacuolar Proton-Translocating ATPases

2011
Archazolid A-15-O-β-D-glucopyranoside and iso-archazolid B: potent V-ATPase inhibitory polyketides from the myxobacteria Cystobacter violaceus and Archangium gephyra.
    Journal of natural products, 2011, May-27, Volume: 74, Issue:5

    Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Female; Glucosides; Humans; Inhibitory Concentration 50; Macrolides; Male; Mice; Molecular Structure; Myxococcales; Thiazoles; Vacuolar Proton-Translocating ATPases

2011
Synthesis and activity of the archazolid western hemisphere.
    Organic & biomolecular chemistry, 2011, Oct-26, Volume: 9, Issue:22

    Topics: Animals; Antineoplastic Agents; Arabidopsis; Biological Assay; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Macrolides; Neoplasms; Potoroidae; Thiazoles; Vacuolar Proton-Translocating ATPases; Vacuoles

2011
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
    International journal of cancer, 2014, May-15, Volume: 134, Issue:10

    Topics: Animals; Blotting, Western; Cathepsin B; Cell Line, Tumor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Lysosomes; Macrolides; MCF-7 Cells; Mice; Mice, Inbred BALB C; Neoplasms; Neoplasms, Experimental; Protein Transport; Receptor, IGF Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Thiazoles; Tumor Burden; Vacuolar Proton-Translocating ATPases

2014
Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells.
    Biochemical pharmacology, 2014, Sep-01, Volume: 91, Issue:1

    Topics: Cell Line, Tumor; Cell Survival; Cholesterol; Drug Resistance, Neoplasm; Endocytosis; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation, Neoplastic; Humans; Indoles; Lipoproteins, LDL; Macrolides; MicroRNAs; Real-Time Polymerase Chain Reaction; Receptors, LDL; Reproducibility of Results; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Thiazoles; Urinary Bladder Neoplasms

2014
Resistance mechanisms of cancer cells to the novel vacuolar H(+)-ATPase inhibitor archazolid B.
    Investigational new drugs, 2014, Volume: 32, Issue:5

    Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Cell Line; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Macrolides; Molecular Docking Simulation; Sequence Analysis, DNA; Thiazoles; Tumor Suppressor Protein p53; Vacuolar Proton-Translocating ATPases

2014
Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid B.
    Toxicology and applied pharmacology, 2014, 11-15, Volume: 281, Issue:1

    Topics: Cell Line, Tumor; Cholesterol; Drug Resistance, Neoplasm; Glioblastoma; Humans; Macrolides; Thiazoles; Up-Regulation

2014
Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase.
    Biochemical pharmacology, 2017, 04-15, Volume: 130

    Topics: Cells, Cultured; Enzyme Inhibitors; Humans; Macrolides; Macrophages; MCF-7 Cells; Thiazoles; Tumor Necrosis Factor-alpha; Vacuolar Proton-Translocating ATPases

2017
Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids.
    ChemMedChem, 2020, 07-20, Volume: 15, Issue:14

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Macrolides; Molecular Structure; Structure-Activity Relationship; Thiazoles

2020