thiazoles has been researched along with archazolid a in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 16 (69.57) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Carlomagno, T; Farès, C; Hassfeld, J; Menche, D; Steinmetz, H | 1 |
| Hassfeld, J; Huss, M; Menche, D; Sasse, F; Wieczorek, H | 1 |
| Hassfeld, J; Li, J; Menche, D; Rudolph, S | 1 |
| Hattori, H; Huang, Z; Mohan, S; Negishi, E; Wang, C; Wang, G | 1 |
| Huss, M; Wieczorek, H | 1 |
| Hassfeld, J; Li, J; Mayer, K; Menche, D; Rudolph, S | 1 |
| Bender, T; Bockelmann, S; Grond, S; Huss, M; Menche, D; Muench, SP; Rudolph, S; von Zezschwitz, P; Wieczorek, H | 1 |
| Bockelmann, S; Essig, S; Horstmann, N; Huss, M; Menche, D; Sasse, F; Wieczorek, H | 1 |
| Egmond, M; Gerritsen, H; Groux-Degroote, S; Neumann, S; Sprong, H; van den Heuvel, D; van der Poel, S; van Meer, G; Wolthoorn, J | 1 |
| Ashcraft, B; Doucette, R; Havko, N; Melly, GC; O'Neil, GW; Sebren, LJ; Tran, AB; Young, JC | 1 |
| Bender, T; Grond, S; Huss, M; Jansen, R; Kunze, B; Osteresch, C; von Zezschwitz, P; Wieczorek, H | 1 |
| Kubisch, R; Liebl, J; Müller, R; Palamidessi, A; Schempp, C; Schreiner, L; Scita, G; Trauner, D; Vereb, G; Vollmar, AM; von Schwarzenberg, K; Wagner, E; Wiedmann, RM; Zahler, S | 1 |
| Basile, T; Bockelmann, S; Carlomagno, T; Huss, M; Menche, D; Persch, E; Wieczorek, H | 1 |
| Bauer, MR; Boeckler, FM; Lange, A; Reutlinger, M; Rupp, M; Schneider, G; Wilcken, R | 1 |
| Gabler, M; Koeberle, A; Lamers, C; Mönch, B; Müller, R; Perna, AM; Reker, D; Reutlinger, M; Rodrigues, T; Schneider, G; Schneider, P; Schubert-Zsilavecz, M; Steinmetz, H; Werz, O | 1 |
| Kubisch-Dohmen, R; Lehr, T; Liebl, J; Menche, D; Schneider, LS; Trauner, D; Ulrich, M; Vollmar, AM; von Schwarzenberg, K | 1 |
| Grunert, M; Jeremias, I; Liebl, J; Menche, D; Müller, R; Schneider, LS; Vick, B; Vollmar, AM; Zhang, S | 1 |
| Bockelmann, S; Gölz, JP; Huss, M; Klare, JP; Mayer, K; Menche, D; Steinhoff, HJ; Wieczorek, H | 1 |
| Bartel, K; Guck, J; Koeberle, A; Menche, D; Müller, R; Ulrich, M; Vollmar, AM; von Schwarzenberg, K; Werz, O; Winzi, M | 1 |
| Ardelt, MA; Lamb, DC; Merk, H; Messer, P; Müller, R; Pachmayr, J; Vollmar, AM; Zahler, S | 1 |
| Bischoff, I; Bräutigam, J; Fürst, R; Luong, B; Menche, D; Müller, R; Schwenk, R | 1 |
| Bartel, K; Müller, R; von Schwarzenberg, K | 1 |
| Abdelrahman, A; Ennenbach, C; Gütschow, M; Lemke, C; Menche, D; Müller, CE; Rivière, S; Vielmuth, C | 1 |
1 review(s) available for thiazoles and archazolid a
| Article | Year |
|---|---|
Inhibitors of V-ATPases: old and new players.
Topics: Alkenes; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Lactones; Macrolides; Molecular Structure; Salicylates; Thiazoles; Vacuolar Proton-Translocating ATPases | 2009 |
22 other study(ies) available for thiazoles and archazolid a
| Article | Year |
|---|---|
Stereochemical determination of Archazolid A and B, highly potent vacuolar-type ATPase inhibitors from the Myxobacterium Archangium gephyra.
Topics: Antimitotic Agents; Macrolides; Molecular Structure; Myxococcales; Stereoisomerism; Thiazoles; Vacuolar Proton-Translocating ATPases | 2006 |
Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor.
Topics: Animals; Antimitotic Agents; Cell Line; Drug Design; Enzyme Inhibitors; Indicators and Reagents; Macrolides; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; Myxococcales; Structure-Activity Relationship; Thiazoles; Vacuolar Proton-Translocating ATPases | 2007 |
Total synthesis of archazolid A.
Topics: Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Myxococcales; Stereoisomerism; Thiazoles | 2007 |
Recent advances in efficient and selective synthesis of di-, tri-, and tetrasubstituted alkenes via Pd-catalyzed alkenylation-carbonyl olefination synergy.
Topics: Alkenes; Carbonic Acid; Catalysis; Fatty Acids, Unsaturated; Lactones; Macrolides; Molecular Structure; Palladium; Pyrones; Stereoisomerism; Thiazoles | 2008 |
Modular total synthesis of archazolid A and B.
Topics: Macrolides; Molecular Conformation; Stereoisomerism; Thiazoles; Vacuolar Proton-Translocating ATPases | 2009 |
Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase.
Topics: Binding Sites; Enzyme Inhibitors; Macrolides; Mutation; Neurospora crassa; Protein Binding; Protein Structure, Secondary; Saccharomyces cerevisiae; Thiazoles; Vacuolar Proton-Translocating ATPases | 2010 |
Archazolid A-15-O-β-D-glucopyranoside and iso-archazolid B: potent V-ATPase inhibitory polyketides from the myxobacteria Cystobacter violaceus and Archangium gephyra.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Female; Glucosides; Humans; Inhibitory Concentration 50; Macrolides; Male; Mice; Molecular Structure; Myxococcales; Thiazoles; Vacuolar Proton-Translocating ATPases | 2011 |
Hyperacidification of trans-Golgi network and endo/lysosomes in melanocytes by glucosylceramide-dependent V-ATPase activity.
Topics: Binding Sites; Endosomes; Fibroblasts; Glucosylceramides; Glycosphingolipids; HeLa Cells; Humans; Hydrogen-Ion Concentration; Lipase; Lysosomes; Macrolides; Melanocytes; Melanosomes; Mutation; Protein Transport; Proton Pumps; Thiazoles; trans-Golgi Network; Tumor Cells, Cultured; Vacuolar Proton-Translocating ATPases | 2011 |
Synthesis and activity of the archazolid western hemisphere.
Topics: Animals; Antineoplastic Agents; Arabidopsis; Biological Assay; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Macrolides; Neoplasms; Potoroidae; Thiazoles; Vacuolar Proton-Translocating ATPases; Vacuoles | 2011 |
The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid.
Topics: Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Macrolides; Manduca; Molecular Conformation; Mutation; Plasmids; Protein Structure, Tertiary; Saccharomyces cerevisiae; Thiazoles; Vacuolar Proton-Translocating ATPases | 2012 |
The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Polarity; Down-Regulation; ErbB Receptors; Female; Humans; Macrolides; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; rab5 GTP-Binding Proteins; rac1 GTP-Binding Protein; Thiazoles; Vacuolar Proton-Translocating ATPases; Xenograft Model Antitumor Assays | 2012 |
Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid.
Topics: Dose-Response Relationship, Drug; Drug Design; Macrolides; Molecular Structure; Solubility; Structure-Activity Relationship; Thiazoles; Vacuolar Proton-Translocating ATPases; Water | 2012 |
Machine learning estimates of natural product conformational energies.
Topics: Adenosine Triphosphatases; Algorithms; Artificial Intelligence; Chemistry, Pharmaceutical; Computational Biology; Enzyme Inhibitors; Macrolides; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Dynamics Simulation; Molecular Structure; Myxococcales; Normal Distribution; Principal Component Analysis; Protein Conformation; Software; Stochastic Processes; Thiazoles | 2014 |
Revealing the macromolecular targets of complex natural products.
Topics: Arachidonic Acid; Biological Products; Drug Design; Drug Discovery; Macrolides; Macromolecular Substances; Molecular Structure; Receptors, Cytoplasmic and Nuclear; Thiazoles; Vacuolar Proton-Translocating ATPases | 2014 |
Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Iron; Macrolides; MCF-7 Cells; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Thiazoles; Tumor Cells, Cultured; Vacuolar Proton-Translocating ATPases; Xenograft Model Antitumor Assays | 2015 |
Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Immunoblotting; Macrolides; Mice; Mice, Inbred NOD; Mice, SCID; Microscopy, Confocal; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transfection; Vacuolar Proton-Translocating ATPases; Xenograft Model Antitumor Assays | 2015 |
EPR Studies of V-ATPase with Spin-Labeled Inhibitors DCC and Archazolid: Interaction Dynamics with Proton Translocating Subunit c.
Topics: Animals; Binding Sites; Cyclic N-Oxides; Dicyclohexylcarbodiimide; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Macrolides; Manduca; Models, Molecular; Spin Labels; Thiazoles; Vacuolar Proton-Translocating ATPases | 2016 |
V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Membrane; Cell Proliferation; Cholesterol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hep G2 Cells; Humans; Liver Neoplasms; Lysosomes; Macrolides; Membrane Fluidity; Mice, SCID; ras Proteins; Signal Transduction; Thiazoles; Time Factors; Vacuolar Proton-Translocating ATPases | 2017 |
Inhibition of the V-ATPase by Archazolid A: A New Strategy to Inhibit EMT.
Topics: Breast Neoplasms; Cadherins; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Macrolides; Neoplasm Metastasis; Neoplastic Stem Cells; Thiazoles; Vacuolar Proton-Translocating ATPases | 2017 |
The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen.
Topics: Antineoplastic Agents; Cathepsin B; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Extracellular Space; Human Umbilical Vein Endothelial Cells; Humans; Integrin beta1; Macrolides; Neoplasms; Thiazoles; Vacuolar Proton-Translocating ATPases | 2018 |
Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells.
Topics: AMP-Activated Protein Kinases; Apoptosis; Cell Line; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Humans; Macrolides; Neoplasms; Phosphorylation; Reactive Oxygen Species; Thiazoles; Vacuolar Proton-Translocating ATPases | 2019 |
Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Macrolides; Molecular Structure; Structure-Activity Relationship; Thiazoles | 2020 |