thiazoles has been researched along with arachidonic acid in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (22.78) | 18.7374 |
| 1990's | 26 (32.91) | 18.2507 |
| 2000's | 25 (31.65) | 29.6817 |
| 2010's | 9 (11.39) | 24.3611 |
| 2020's | 1 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Bin, Z; Kun, L | 1 |
| Cass, WA; Dunwiddie, TV; Fitzpatrick, FA; Taylor, M; Zahniser, NR | 1 |
| Baldari, CT; Donati, D; Macchia, G; Massone, A; Parente, L; Telford, JL | 1 |
| Quinlan, MF; Schwartz, LW; Turner, CR; Wheeldon, EB | 1 |
| Bartlett, RR; Schleyerbach, R; Thorwart, W; Weithmann, KU | 1 |
| Dunn, WD; Nadler, J; Natarajan, R; Stern, N | 1 |
| Badger, AM; Hanna, N; Olivera, D; Talmadge, JE | 1 |
| Benslay, DN; Bertsch, B; Ho, PP; Panetta, JA; Phillips, ML; Towner, RD; Wang, L | 1 |
| Bonne, C; Dornand, J; Emerit, I; Giroud, JP; Griswold, DE; Latour, E; Modat, G; Muller, A; Roch, M; Tissie, G | 1 |
| Hattori, H; Nakashima, S; Nozawa, Y; Suganuma, A; Tohmatsu, T | 1 |
| DiMartino, MJ; Gleason, JG; Godfrey, R; Griswold, DE; Hanna, N; Marshall, PJ; Newton, J; Poste, G; Sarau, HM; Webb, EF | 1 |
| Joseph, S; Kakkar, VV; Krishnamurthi, S | 1 |
| Mahadevappa, VG; Sicilia, FJ | 1 |
| Benveniste, J; Braquet, P; Chignard, M; Korth, R; Le Couedic, JP; Norel, X; Nunez, D; Spinnewyn, B | 1 |
| Griswold, DE; Hanna, N; Schwartz, L; Webb, E | 1 |
| Hayashi, Y; Hirasawa, N; Ohuchi, K; Sugidachi, A; Tsurufuji, S; Watanabe, M | 1 |
| Braquet, P; Neuwirth, R; Satriano, JA; Schlondorff, D; Singhal, P | 1 |
| Halenda, SP; Rehm, AG | 1 |
| Myers, AK; Nakanishi, T; Ramwell, P | 1 |
| DiMartino, MJ; Griswold, DE; Hanna, N; Hillegass, LM; Meunier, PC | 1 |
| Bian, K; Inatomi, A; Lu, W; Okamura, T; Toda, N | 1 |
| Griswold, DE; Hanna, N; Lee, JC; Votta, B | 1 |
| Inada, Y; Nishikawa, K; Nomura, H; Terashita, Z; Tsushima, S; Yoshioka, Y | 1 |
| Carlson, RP; Chang, J; Lewis, AJ | 1 |
| Ikesue, K; Inoue, H; Taniguchi, Y | 1 |
| Oda, M; Yamashita, A; Yokota, K | 1 |
| Kuno, A; Ohkubo, M; Sakai, H; Takasugi, H | 1 |
| Breton, J; Griswold, DE; Marshall, PJ; Torphy, TJ; Webb, EF; White, JR | 1 |
| el Bawab, S; Lagarde, M; Macovschi, O; Prigent, AF | 1 |
| Inagami, T; Inui, H; Kitami, Y; Kondo, T; Konishi, F | 1 |
| Bird, IN; Daniels, RH; Elmore, MA; Finnen, MJ; Hill, ME | 1 |
| Behnke, M; Gilman, A; Graham, AG; Lazer, ES; Miao, CK; Pal, K; Sorcek, R; Spero, DM; Watrous, JM; Wong, HC | 1 |
| Acamovic, F; Mackie, SC; Morrison, KS; Palmer, RM; Thompson, MG | 1 |
| Bon, C; Faili, A; Hatmi, M; Mounier, C; Vargaftig, BB | 1 |
| Bögel, R; Engelhardt, G; Schnitzer, C; Utzmann, R | 1 |
| Bögel, R; Engelhardt, G; Schnitzler, C; Utzmann, R | 1 |
| Morimoto, Y; Oda, M; Yamamoto, N; Yamashita, A; Yokota, K | 1 |
| Oda, M; Yamamoto, N; Yamashita, A; Yokota, K | 1 |
| Crews, BC; Kalgutkar, AS; Marnett, LJ | 1 |
| Matsuo, K; Oda, M; Yamashita, A; Yokota, K | 1 |
| Capasso, A; Sorrentino, L | 1 |
| Eichberg, J; Kuruvilla, R | 1 |
| de Meijer, A; de Metz, M; Novakova, I; Thomas, C; Verbruggen, B; Vollaard, H | 1 |
| Amoretti, L; Caretta, A; Manotti, C; Vicini, P | 1 |
| Hirasawa, N; Kushihara, M; Ohuchi, K; Takahagi, H; Takasaki, W; Takayanagi, M; Yamashita, M | 1 |
| Hishinuma, T; Mizugaki, M; Yamazaki, T | 1 |
| Bernat, A; Herbert, JM; Lalé, A; Roque, C; Savi, P; Zamboni, G | 1 |
| Amoretti, L; Ballabeni, V; Barocelli, E; Tognolini, M; Vicini, P | 1 |
| Chang, DM; Hsieh, TC; Hsu, CT; Kuo, SY; Young, TH | 1 |
| Hla, T; Inoue , K; Kawahito, Y; Kohno, M; Sano, H; Tsubouchi, Y | 1 |
| Bäumer, W; Kietzmann, M | 1 |
| Elverdin, JC; Faletti, A; Franchi, A; Lomniczi, A; McCann, SM; Mohn, C; Rettori, V | 1 |
| Bláha, L; Hofmanová, J; Kozubík, A; Minksová, K; Soucek, K; Stika, J; Vondrácek, J | 1 |
| Levine, L | 1 |
| Capriotti, T | 1 |
| Boutin, JA; Nosjean, O | 1 |
| Bécuwe, P; Bianchi, A; Dauça, M; Franck, P | 1 |
| Dosoretz, A; Holland, JF; Kirschenbaum, A; Levine, AC; Liu, XH; Lu, M; Yao, S | 1 |
| Chen, WY; Fang, X; Mao, LZ; Roldan, ER; Shi, QX; Yu, SQ; Yuan, YY | 1 |
| Bishop-Bailey, D; Warner, TD | 1 |
| Rao, GN; Yellaturu, CR | 1 |
| Bijian, K; Cybulsky, AV; Khadir, A; Le Berre, L; Papillon, J; Takano, T | 1 |
| Chirita, CN; Kuret, J | 1 |
| Chirita, C; Kuret, J; Necula, M | 1 |
| Limonta, P; Montagnani Marelli, M; Moretti, RM; Motta, M; Sala, A | 1 |
| Backlund, MG; Blackwell, TS; DuBois, RN; Everhart, MB; Gao, L; Han, W; Milne, GL; Morrow, JD; Musiek, ES; Vidari, G; Wang, D; Zanoni, G | 1 |
| Buerkert, E; Fischer, L; Poeckel, D; Steinhilber, D; Werz, O | 1 |
| Facchini, G; Ferrari, F; Gemelli, C; Grande, A; Lymboussaki, A; Mavilio, F; Testa, A | 1 |
| Guo, L; Li, Q; Li, Y; Liang, D; Liang, S; Tang, X; Wang, Z; Zhang, R; Zhu, D | 1 |
| Cheon, HG; Cho, YS; Kang, NS; Kim, CH; Surh, JH; Yoo, SE | 1 |
| Chalimoniuk, M; Cui, J; Ding, S; Gu, Z; He, Y; Lee, JC; Simonyi, A; Sun, AY; Sun, GY; Weisman, GA; Wood, WG | 1 |
| Bal, R; Baydaş, G; Etem, E; Kuloğlu, T; Naziroğlu, M; Türk, G; Yılmaz, Ö | 1 |
| Hata, H; Hata, M; Nakata, K; Sezai, A; Shiono, M; Soma, M; Wakui, S; Yoshitake, I | 1 |
| Anderson, KE; Austin, J; Carbone, L; Escobar, EP | 1 |
| Cap, AP; Dubick, MA; Martini, AK; Martini, WZ; Rodriguez, CM | 1 |
| Barbayianni, E; Constantinou-Kokotou, V; Dennis, EA; Feuerherm, AJ; Johansen, B; Kokotos, G; Magrioti, V; Nguyen, T; Shah, I; Sæther, M | 1 |
| Gabler, M; Koeberle, A; Lamers, C; Mönch, B; Müller, R; Perna, AM; Reker, D; Reutlinger, M; Rodrigues, T; Schneider, G; Schneider, P; Schubert-Zsilavecz, M; Steinmetz, H; Werz, O | 1 |
| Aghazadeh-Habashi, A; Asghar, W; Jamali, F | 1 |
| Panczyszyn-Trzewik, P; Rzezniczek X, S; Sowa-Kucma, M; Stachowicz, K | 1 |
2 review(s) available for thiazoles and arachidonic acid
| Article | Year |
|---|---|
The new NSAIDs: cox-2 inhibitors.
Topics: Advertising; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Industry; Gastrointestinal Diseases; Humans; Isoenzymes; Lactones; Meloxicam; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Safety; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2000 |
Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part?
Topics: Antiporters; Arachidonic Acid; DNA-Binding Proteins; Humans; Ligands; Linoleic Acid; Lipid Metabolism; Models, Biological; Models, Chemical; Organic Anion Transporters; Oxidation-Reduction; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Transcription Factors | 2002 |
4 trial(s) available for thiazoles and arachidonic acid
| Article | Year |
|---|---|
Meloxicam, 15 mg/day, spares platelet function in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blood Platelets; Cross-Over Studies; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Male; Meloxicam; Platelet Aggregation; Radioimmunoassay; Reference Values; Thiazines; Thiazoles; Thromboxane B2; Time Factors | 1999 |
Endoscopic comparison of the gastroduodenal safety and the effects on arachidonic acid products between meloxicam and piroxicam in the treatment of osteoarthritis.
Topics: Adult; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Digestive System; Dinoprostone; Double-Blind Method; Endoscopy, Digestive System; Female; Gastric Juice; Humans; Leukotriene B4; Male; Meloxicam; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Piroxicam; Safety; Thiazines; Thiazoles; Thromboxane B2 | 2001 |
Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients (NU-FLASH Trial).
Topics: Aged; Albuminuria; Allopurinol; Arachidonic Acid; Blood Pressure; C-Reactive Protein; Cardiac Surgical Procedures; Cholesterol; Creatinine; Cystatin C; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Lipoproteins, LDL; Male; Middle Aged; Pulse Wave Analysis; Stroke Volume; Thiazoles; Uric Acid | 2013 |
Platelet aggregation in rhesus macaques (Macaca mulatta) in response to short-term meloxicam administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Humans; Macaca mulatta; Male; Meloxicam; Pain, Postoperative; Platelet Aggregation; Species Specificity; Thiazines; Thiazoles | 2013 |
73 other study(ies) available for thiazoles and arachidonic acid
| Article | Year |
|---|---|
Inhibition by glaucocalyxin A of aggregation of rabbit platelets induced by ADP, arachidonic acid and platelet-activating factor, and inhibition of [3H]-PAF binding.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Diterpenes, Kaurane; Drugs, Chinese Herbal; Female; Glyceryl Ethers; In Vitro Techniques; Kinetics; Male; Molecular Structure; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thiazoles | 1992 |
Arachidonic acid metabolites do not mediate modulation of neurotransmitter release by adenosine in rat hippocampus or striatum.
Topics: Acetophenones; Adenosine; Animals; Arachidonic Acid; Arachidonic Acids; Baclofen; Carbachol; Corpus Striatum; Evoked Potentials; Hippocampus; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Masoprocol; Neurotransmitter Agents; Phospholipases; Rats; Rats, Inbred Strains; Second Messenger Systems; Thiazoles | 1990 |
Induction of gene expression by IL-1 in NIH 3T3 cells. Possible requirement of protein kinase C activity and independence from arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; Interleukin-1; Lipoxygenase Inhibitors; Mice; Protein Kinase C; Pyrimidinones; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thiazoles; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1990 |
Therapeutic intervention in a rat model of ARDS: I. Dual inhibition of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal; Erythrocyte Count; Escherichia coli; Hematocrit; Hemoglobins; Imidazoles; Leukocyte Count; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Methylprednisolone; Neutrophils; Platelet Count; Rats; Rats, Inbred Strains; Respiratory Distress Syndrome; Thiazoles | 1990 |
Pharmacological profile of HWA-131, a novel antiinflammatory agent with immunomodulating properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthritis, Experimental; Arthus Reaction; Cell Division; Collagen; Prednisolone; Rats; Thiazoles; Triazines | 1990 |
Key role of diacylglycerol-mediated 12-lipoxygenase product formation in angiotensin II-induced aldosterone synthesis.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aldosterone; Angiotensin II; Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Hydroxyeicosatetraenoic Acids; Lipoprotein Lipase; Male; Phosphotransferases; Pyrimidinones; Rats; Rats, Inbred Strains; Thiazoles; Zona Glomerulosa | 1990 |
Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Disease Models, Animal; Galactosamine; Imidazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Propionibacterium acnes; Shock, Septic; Thiazoles; Tumor Necrosis Factor-alpha | 1989 |
The anti-inflammatory effects of LY178002 and LY256548.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthritis; Arthritis, Experimental; Cyclooxygenase Inhibitors; Freund's Adjuvant; Guinea Pigs; In Vitro Techniques; Neutrophils; Thiazoles; Thiazolidines | 1989 |
2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 1st communication: in vitro studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cells, Cultured; Chromosome Aberrations; Cyclooxygenase Inhibitors; Free Radicals; Humans; In Vitro Techniques; Leukotrienes; Lipid Peroxidation; Lipoxygenase Inhibitors; Oxygen Consumption; Rabbits; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thiazoles | 1989 |
A role of diacylglycerol kinase in stimulus-secretion coupling of human platelets. Dissociation of serotonin secretion from Ca2+ mobilization.
Topics: Aminoquinolines; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diacylglycerol Kinase; Enzyme Inhibitors; Humans; Phosphotransferases; Platelet Aggregation; Pyrimidinones; Serotonin; Thiazoles; Thrombin | 1987 |
SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Humans; Imidazoles; Inflammation; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Pyrazoles; Rats; SRS-A; Thiazoles | 1987 |
Differential effects of the diacylglycerol kinase inhibitor R59022 on thrombin versus collagen-induced human platelet secretion.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Collagen; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Ethers; Glycerides; Humans; Ionomycin; Phosphoproteins; Phosphotransferases; Platelet Aggregation; Pyrimidinones; Serotonin; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin | 1988 |
The inhibition of arachidonic acid mobilization in human platelets by R59 022, a diacylglycerol kinase inhibitor.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Diacylglycerol Kinase; Humans; In Vitro Techniques; Membrane Lipids; Phosphatidylethanolamines; Phosphatidylserines; Phospholipases A; Phospholipases A2; Phospholipids; Phosphotransferases; Platelet Aggregation; Pyrimidinones; Thiazoles; Thrombin | 1988 |
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Benzofurans; Benzopyrans; Blood Platelets; Diterpenes; Ginkgolides; Humans; In Vitro Techniques; Lactones; Lignans; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Thiazoles | 1986 |
Arachidonic acid-induced inflammation: inhibition by dual inhibitor of arachidonic acid metabolism, SK&F 86002.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Ibuprofen; Imidazoles; Inflammation; Male; Masoprocol; Mice; Mice, Inbred BALB C; Naproxen; Peritonitis; Piroxicam; Pyrazoles; Thiazoles | 1987 |
Platelet-activating factor in the inflammatory exudate in the anaphylactic phase of allergic inflammation in rats.
Topics: Adenosine Diphosphate; Anaphylaxis; Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Exudates and Transudates; Inflammation; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Effect of platelet activating factor antagonists on cultured rat mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Calcimycin; Cells, Cultured; Dinoprostone; Diterpenes; Dose-Response Relationship, Drug; Ginkgolides; Glomerular Mesangium; Lactones; Lignans; Male; Plant Extracts; Platelet Activating Factor; Prostaglandins E; Rats; Thiazoles | 1987 |
Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diglycerides; Diterpenes; Drug Synergism; Humans; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin | 1987 |
Antagonism of PAF-induced death in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Diterpenes; Epinephrine; Fatty Acids, Unsaturated; Furans; Ginkgolides; Hydrazines; Lactones; Male; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Pyridines; Thiazoles; Thromboxane A2 | 1988 |
Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis; Collagen; Dexamethasone; Ibuprofen; Imidazoles; Male; Mice; Mice, Inbred DBA; Pyrazoles; Serum Amyloid P-Component; Thiazoles | 1988 |
Prostaglandins involved in contractions by angiotensin II and bradykinin of isolated dog sphincter pupillae.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Bradykinin; Dinoprost; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins; Pupil; Thiazoles; Thromboxane A2 | 1988 |
Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Humans; Imidazoles; In Vitro Techniques; Interleukin-1; Kinetics; Lipoxygenase Inhibitors; Monocytes; Thiazoles | 1988 |
CV-3988 - a specific antagonist of platelet activating factor (PAF).
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Calcimycin; Collagen; Dose-Response Relationship, Drug; Male; Micelles; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thiazoles | 1983 |
A comparative study of the antiinflammatory activity of fentiazac and its major metabolite, p-hydroxy fentiazac.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis; Arthritis, Experimental; Macrophages; Male; Rats; Rats, Inbred Strains; Thiazoles | 1984 |
[Synthesis and antiplatelet activity of 2-amino-4,5-diphenylthiazole derivatives].
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Cells, Cultured; Collagen; Cyclooxygenase Inhibitors; Platelet Aggregation Inhibitors; Rabbits; Structure-Activity Relationship; Thiazoles | 1995 |
Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Extracorporeal Circulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Silver Nitrate; Thiazoles; Thrombosis; Ticlopidine | 1995 |
Studies on cerebral protective agents. VII. Synthesis of novel 4-arylazole derivatives with anti-anoxic activity.
Topics: Animals; Arachidonic Acid; Brain Edema; Chemical Phenomena; Chemistry, Physical; Hypoxia, Brain; Imidazoles; Lethal Dose 50; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Oxazoles; Structure-Activity Relationship; Thiazoles | 1995 |
Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Ear, External; Eicosanoids; Histamine Release; Humans; Imidazoles; Inflammation; Leukotriene B4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Monocytes; Nadolol; Naproxen; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazoles; Pyrrolidinones; Receptors, Adrenergic, beta; Rolipram; SRS-A; Thiazoles | 1993 |
Time-course changes in content and fatty acid composition of phosphatidic acid from rat thymocytes during concanavalin A stimulation.
Topics: Animals; Arachidonic Acid; Concanavalin A; Diacylglycerol Kinase; Diglycerides; Fatty Acids; Fatty Acids, Unsaturated; Lymphocyte Activation; Male; Membrane Lipids; Phosphatidic Acids; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles; Thymus Gland; Time Factors | 1995 |
Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Becaplermin; Cell Division; Cells, Cultured; Diacylglycerol Kinase; DNA; Enzyme Activation; Genistein; Humans; Isoflavones; Mitogens; Muscle, Smooth, Vascular; Myristic Acid; Myristic Acids; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyrimidinones; Rats; Recombinant Proteins; Signal Transduction; Staurosporine; Thiazoles | 1994 |
Endothelial cell-associated platelet-activating factor primes neutrophils for enhanced superoxide production and arachidonic acid release during adhesion to but not transmigration across IL-1 beta-treated endothelial monolayers.
Topics: Arachidonic Acid; Azepines; Cell Adhesion; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; In Vitro Techniques; Interleukin-1; Neutrophil Activation; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides; Thiazoles; Thiazolidines; Triazoles | 1994 |
Benzoxazolamines and benzothiazolamines: potent, enantioselective inhibitors of leukotriene biosynthesis with a novel mechanism of action.
Topics: Arachidonic Acid; Benzoxazoles; Humans; In Vitro Techniques; Leukotriene Antagonists; Leukotrienes; Neutrophils; Stereoisomerism; Thiazoles | 1994 |
Arachidonate activation of protein kinase C may be involved in the stimulation of protein synthesis by insulin in L6 myoblasts.
Topics: Animals; Arachidonic Acid; Cell Line; Cyclohexanones; Cyclooxygenase Inhibitors; Diglycerides; Enzyme Activation; Indoles; Insulin; Lipoprotein Lipase; Muscle Proteins; Muscles; Protein Kinase C; Pyrimidinones; Rats; Thiazoles | 1993 |
Competitive inhibition of phospholipase A2 activity by the platelet-activating factor antagonist Ro 19-3704 and evidence for a novel suppressive effect on platelet activation.
Topics: Animals; Arachidonic Acid; Blood Platelets; Glyceryl Ethers; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Activation; Rabbits; Serum Albumin, Bovine; Thiazoles | 1993 |
Meloxicam: influence on arachidonic acid metabolism. Part 1. In vitro findings.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Brain; Cattle; Cell-Free System; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Guinea Pigs; Isoenzymes; Lipopolysaccharides; Macrophages, Peritoneal; Male; Meloxicam; Placenta; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Thiazines; Thiazoles | 1996 |
Meloxicam: influence on arachidonic acid metabolism. Part II. In vivo findings.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Brain; Convulsants; Cyclooxygenase Inhibitors; Dinoprostone; Female; Gastric Juice; Inflammation; Isoenzymes; Kidney; Leukotriene B4; Male; Meloxicam; Mice; Pentylenetetrazole; Pleurisy; Rats; Stomach; Thiazines; Thiazoles | 1996 |
Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functions.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Edema; Erythema; Gastric Mucosa; Guinea Pigs; Humans; Mice; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Serotonin; Species Specificity; Thiazoles; Thrombin; Ultraviolet Rays | 1995 |
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; Gerbillinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipid Peroxidation; Male; Pyrroles; Thiazoles | 1996 |
Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Hemin; Ibuprofen; Kinetics; Molecular Structure; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostanoic Acids; Protein Binding; Protein Conformation; Sulfonamides; Thiazoles; Trypsin | 1996 |
The mechanism of action of KBT-3022, a new antiplatelet agent.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arachidonic Acid; Blood Platelets; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Epoprostenol; Guinea Pigs; In Vitro Techniques; Intramolecular Oxidoreductases; Isomerases; Male; Phosphatidic Acids; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rabbits; Thiazoles; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 1997 |
Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Masoprocol; Meloxicam; Morphine; Muscle Contraction; Naloxone; Narcotic Antagonists; Phospholipases A; Phospholipases A2; Quinacrine; Substance-Related Disorders; Thiazines; Thiazoles; Tolmetin | 1997 |
Depletion of phospholipid arachidonoyl-containing molecular species in a human Schwann cell line grown in elevated glucose and their restoration by an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Arachidonic Acid; Benzothiazoles; Cell Division; Culture Media; Enzyme Inhibitors; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Mannitol; Neurofibroma; Organic Chemicals; Phospholipids; Phthalazines; Piperazines; Pyrimidines; Schwann Cells; Sorbitol; Thiazoles; Tumor Cells, Cultured | 1998 |
Comparison of in vitro and ex vivo antiplatelet effects of 1,2-benzisothiazolin-3-one and its 2-amino derivative.
Topics: Adenosine Diphosphate; Adolescent; Adult; Animals; Arachidonic Acid; Collagen; Female; Humans; In Vitro Techniques; Indicators and Reagents; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thiazoles | 1999 |
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone has a reducing effect on thromboxane production.
Topics: Arachidonic Acid; Blood Platelets; Chromans; Diabetes Mellitus, Type 2; Fibrinolytic Agents; Gas Chromatography-Mass Spectrometry; Humans; Leukemia, Erythroblastic, Acute; Rosiglitazone; Thiazoles; Thiazolidinediones; Thromboxane A2; Troglitazone; Tumor Cells, Cultured; Vitamin E | 2000 |
Effect of aspirin on platelet desaggregation induced by SR121566, a potent GP-IIb/IIIa antagonist.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Benzylamines; Blood Flow Velocity; Blood Platelets; Carotid Arteries; Disease Models, Animal; Electric Stimulation; Female; Fibrinolytic Agents; Humans; Male; Oligopeptides; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Recombinant Proteins; Thiazoles; Thrombosis; Thrombospondins; Tissue Plasminogen Activator | 2000 |
2-Amino-Benzo[d]isothiazol-3-one derivatives: synthesis and assessment of their antiplatelet/spasmolytic effects.
Topics: Adenosine Diphosphate; Animals; Aorta; Arachidonic Acid; Benzaldehydes; Guinea Pigs; Ileum; Inhibitory Concentration 50; Male; Models, Animal; Muscle Contraction; Parasympatholytics; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiazoles | 2000 |
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
Topics: Arachidonic Acid; Arthritis, Rheumatoid; Chromans; Cyclooxygenase 2; Cysteine; Dinoprostone; Feedback; Humans; Isoenzymes; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Membrane Proteins; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Effects of steroidal and non-steroidal antiphlogistic drugs on eicosanoid synthesis in irritated skin: studies with the isolated perfused bovine udder.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cattle; Clobetasol; Clonixin; Culture Techniques; Dinoprostone; Disease Models, Animal; Eicosanoids; Female; Glucocorticoids; Indomethacin; Mammary Glands, Animal; Meloxicam; Skin Physiological Phenomena; Thiazines; Thiazoles | 2001 |
Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Autonomic Agents; Cyclooxygenase 2; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Injections, Intraperitoneal; Isoenzymes; Lipopolysaccharides; Male; Meloxicam; Methacholine Chloride; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Saliva; Submandibular Gland; Thiazines; Thiazoles | 2001 |
Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.
Topics: Apoptosis; Arachidonic Acid; Caspase 3; Caspases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome c Group; Cytosol; Dose-Response Relationship, Drug; Drug Synergism; HL-60 Cells; Humans; Indomethacin; Isoenzymes; Masoprocol; Membrane Proteins; Peroxisome Proliferators; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin; Tumor Necrosis Factor-alpha | 2001 |
Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.
Topics: Alitretinoin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Celecoxib; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Kinetics; Liver; Prostaglandin D2; Prostaglandins A; Pyrazoles; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin | 2001 |
Induction of MnSOD gene by arachidonic acid is mediated by reactive oxygen species and p38 MAPK signaling pathway in human HepG2 hepatoma cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Blotting, Western; Carcinoma, Hepatocellular; Cell Division; DNA Primers; Enzyme Induction; Enzyme Inhibitors; Flow Cytometry; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Superoxides; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2002 |
Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.
Topics: Active Transport, Cell Nucleus; Arachidonic Acid; Catalysis; Cell Nucleus; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Green Fluorescent Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Intercellular Signaling Peptides and Proteins; Isoenzymes; Luminescent Proteins; Lymphokines; Male; MAP Kinase Signaling System; Meloxicam; Membrane Proteins; Nitrobenzenes; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Thiazines; Thiazoles; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Zona pellucida induces activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa.
Topics: Acrosome Reaction; Animals; Arachidonic Acid; Aristolochic Acids; Calcium; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Lanthanum; Lysophosphatidylcholines; Male; Pertussis Toxin; Phospholipases A; Phospholipases A2; Pyrimidinones; Sperm Capacitation; Spermatozoa; Thiazoles; Zona Pellucida | 2003 |
PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist.
Topics: Animals; Apoptosis; Arachidonic Acid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Isoenzymes; Ligands; Models, Biological; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 2003 |
A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells.
Topics: Animals; Arachidonic Acid; Blotting, Western; Coloring Agents; DNA; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Group VI Phospholipases A2; Imidazoles; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Naphthalenes; Oleic Acid; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Pyridines; Pyrones; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazolium Salts; Thiazoles; Thrombin; Time Factors | 2003 |
The actin cytoskeleton facilitates complement-mediated activation of cytosolic phospholipase A2.
Topics: Actin Cytoskeleton; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cells, Cultured; Complement System Proteins; Cytochalasin D; Enzyme Activation; Epithelial Cells; ErbB Receptors; Group IV Phospholipases A2; Kidney Glomerulus; Phospholipases A; Phospholipases A2; Rats; rhoA GTP-Binding Protein; Signal Transduction; Thiazoles; Thiazolidines | 2004 |
Evidence for an intermediate in tau filament formation.
Topics: Alzheimer Disease; Anions; Arachidonic Acid; Benzothiazoles; Humans; Hydrophobic and Hydrophilic Interactions; Intermediate Filament Proteins; Micelles; Microspheres; Neurofibrillary Tangles; Neurofilament Proteins; Recombinant Proteins; Spectrometry, Fluorescence; Static Electricity; Surface Properties; Surface-Active Agents; tau Proteins; Thiazoles | 2004 |
Ligand-dependent inhibition and reversal of tau filament formation.
Topics: Arachidonic Acid; Benzothiazoles; Carbocyanines; Coloring Agents; Humans; Ligands; Microscopy, Electron; Microspheres; Neurofilament Proteins; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Proteins; tau Proteins; Thiazoles | 2004 |
Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty acids on prostate cancer cells: crucial role of 5-lipoxygenase.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Division; Humans; Hydroxyeicosatetraenoic Acids; Linoleic Acid; Male; Neoplasms, Hormone-Dependent; Nerve Tissue Proteins; Nuclear Receptor Subfamily 1, Group F, Member 1; Prostatic Neoplasms; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiosemicarbazones; Trans-Activators; Tumor Cells, Cultured | 2004 |
Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Arachidonic Acid; Arachidonic Acids; Blotting, Northern; Blotting, Western; Bone Marrow Cells; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Cell Nucleus; Cyclic N-Oxides; Cyclooxygenase 2; Cyclopentanes; F2-Isoprostanes; Genes, Reporter; Hydroxylamine; I-kappa B Proteins; Inflammation; Inhibitory Concentration 50; Isoprostanes; Lipopolysaccharides; Macrophages; Mice; Microscopy, Fluorescence; Models, Chemical; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; PPAR gamma; Prostaglandins; Protein Biosynthesis; Tetrazolium Salts; Thiazoles; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2005 |
Inhibitors of actin polymerisation stimulate arachidonic acid release and 5-lipoxygenase activation by upregulation of Ca2+ mobilisation in polymorphonuclear leukocytes involving Src family kinases.
Topics: Actins; Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cytochalasin D; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nucleic Acid Synthesis Inhibitors; Polymers; src-Family Kinases; Thapsigargin; Thiazoles; Thiazolidines; Up-Regulation | 2005 |
PPARdelta is a ligand-dependent negative regulator of vitamin D3-induced monocyte differentiation.
Topics: Antigens, CD34; Antigens, Differentiation; Arachidonic Acid; Cell Differentiation; Cell Line; Cholecalciferol; Computational Biology; Databases, Factual; Epoprostenol; Gene Expression Profiling; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Ligands; Monocytes; PPAR delta; Thiazoles; Up-Regulation | 2009 |
15-HETE suppresses K(+) channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells.
Topics: Apoptosis; Arachidonic Acid; Caspase 3; Humans; Hydrogen Peroxide; Hydroxyeicosatetraenoic Acids; Hypoxia; Mitochondria; Models, Biological; Myocytes, Smooth Muscle; Potassium; Potassium Channels; Proto-Oncogene Proteins c-bcl-2; Pulmonary Artery; Tetrazolium Salts; Thiazoles | 2009 |
Identification of 4-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-2,6-dimethyl-phenol (KR-33749) as an inhibitor of 5-lipoxygenase with potent antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Line, Tumor; Dermatitis, Atopic; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Edema; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Osmolar Concentration; Rats; Recombinant Proteins; Skin; Skin Diseases; Thiazoles; Time Factors; Xylenes | 2010 |
Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Arachidonic Acid; Calcium; Catechin; Cell Survival; Cells, Cultured; Cerebral Cortex; Drug Interactions; Embryo, Mammalian; Glycoproteins; L-Lactate Dehydrogenase; N-Methylaspartate; NADPH Oxidases; Neurons; Neuroprotective Agents; Oxazines; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Xanthenes | 2011 |
Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats.
Topics: Animals; Apoptosis; Arachidonic Acid; DNA Fragmentation; Epididymis; Fatty Acids, Unsaturated; Glutathione; Guanidines; In Situ Nick-End Labeling; Insecticides; Male; Neonicotinoids; Organ Size; Palmitic Acid; Rats; Rats, Wistar; Spermatozoa; Testis; Testosterone; Thiazoles; Toxicity Tests, Subchronic | 2012 |
Acetaminophen and meloxicam inhibit platelet aggregation and coagulation in blood samples from humans.
Topics: Acetaminophen; Arachidonic Acid; Blood Cells; Blood Coagulation; Blood Specimen Collection; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Humans; Meloxicam; Partial Thromboplastin Time; Platelet Aggregation; Prothrombin Time; Thiazines; Thiazoles; Thrombelastography | 2014 |
Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo.
Topics: Animals; Arachidonic Acid; Arthritis; Blood Proteins; Cell Line, Tumor; Collagen; Cytosol; Dinoprostone; Drug Design; Group IV Phospholipases A2; Humans; Ketones; Male; Mice; Oleic Acid; Synovial Membrane; Thiazoles | 2014 |
Revealing the macromolecular targets of complex natural products.
Topics: Arachidonic Acid; Biological Products; Drug Design; Drug Discovery; Macrolides; Macromolecular Substances; Molecular Structure; Receptors, Cytoplasmic and Nuclear; Thiazoles; Vacuolar Proton-Translocating ATPases | 2014 |
Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Celecoxib; Cytochrome P-450 Enzyme System; Heart; Hydroxyeicosatetraenoic Acids; Inflammation; Kidney; Lactones; Male; Meloxicam; Rats; Rats, Sprague-Dawley; Sulfones; Thiazines; Thiazoles | 2018 |
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arachidonic Acid; Cell Adhesion; Cell Adhesion Molecules; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Depressive Disorder, Major; Imipramine; Mice; Mice, Inbred C57BL; Nitrobenzenes; Pyridines; Receptor, Metabotropic Glutamate 5; RNA, Messenger; Sulfonamides; Thiazoles | 2022 |