thiazoles has been researched along with amyloid beta-peptides in 173 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (12.14) | 18.2507 |
| 2000's | 75 (43.35) | 29.6817 |
| 2010's | 77 (44.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernhagen, J; Buck, A; Hirsch, T; Kapurniotu, A; Schmauder, A; Tatarek-Nossol, M; Weber, M | 1 |
| Kawahara, M; Kobayashi, K; Kuroda, Y; Mori, H; Muramoto, K | 1 |
| Fukui, Y; Kageyama, H; Ueda, K | 1 |
| Hawtin, SR; Pollack, SJ; Sadler, II; Shearman, MS; Tailor, VJ | 1 |
| Hawtin, SR; Pollack, SJ; Sadler, II; Shearman, MS; Tailor, V | 1 |
| Naiki, H; Nakakuki, K | 1 |
| Audia, JE; Drzewiecki, GJ; Fuson, K; Hyslop, PA; May, PC; Rydel, RE; Wogulis, M; Wright, S; Zhang, Z | 1 |
| Abe, K; Kimura, H | 1 |
| Cunningham, AM; Hipkiss, AR; Mayer, S; Michaelis, J; Müller, R; Münch, G; Neumann, A; Riederer, P; Schinzel, R | 1 |
| LeVine, H | 2 |
| Bradt, B; Cooper, N; Rogers, J; Webster, S | 1 |
| Abe, K; Kato, M; Saito, H | 1 |
| Melchor, JP; Ruffini, L; Van Nostrand, WE | 1 |
| Munekata, E; Takenouchi, T | 1 |
| Goyal, S; Heroux, J; Hughes, SR; Khorkova, O; Knaeblein, J; Riedel, NG; Sahasrabudhe, S | 1 |
| Beal, MF; Kowall, NW; McKee, AC; Schumacher, JS | 1 |
| Alvarez, A; Bronfman, FC; Inestrosa, NC; Morgan, C | 1 |
| Aksenov, MY; Aksenova, MV; Butterfield, DA; Markesbery, WR | 1 |
| Fuson, KS; Mark, RJ; May, PC | 1 |
| Hayashi, Y; Kaname, H; Matsuda, K; Monji, A; Tashiro, K; Tashiro, N; Yoshida, I | 1 |
| Dickson, DW; Lee, VM; Trojanowski, JQ; Wang, J | 1 |
| Boelens, WC; Bosman, GJ; de Jong, WW; Overkamp, PS; Reijnen-Aalbers, A; Renkawek, K; Stege, GJ; van Rijk, AF; Verschuure, P | 1 |
| Brack, C; Brockhaus, M; Herrmann, M; Hock, C; Müller-Spahn, F; Olivieri, G; Renard, P; Stähelin, HB | 1 |
| Cannady, SB; Combs, CK; Johnson, DE; Karlo, JC; Landreth, GE | 1 |
| Isobe, I; Michikawa, M; Yanagisawa, K | 1 |
| Barelli, H; Checler, F; Morain, P; Petit, A | 1 |
| Castillo, GM; Kirschner, DA; Lukito, W; Peskind, E; Raskind, M; Snow, AD; Yee, AG | 1 |
| Baysang, G; Brack, C; Brockhaus, M; Meier, F; Müller-Spahn, F; Olivieri, G; Stähelin, HB | 1 |
| Buford, JP; Butko, P; Cannon, GC; Goodwin, JS; McCormick, CL; Stroud, PA | 1 |
| Hashioka, S; Monji, A; Tashiro, K; Tashiro, N; Utsumi, H; Yoshida, I | 1 |
| Gur, TL; Hou, C; Kung, HF; Kung, MP; Lee, VM; Plössl, K; Skovronsky, DM; Trojanowski, JQ; Zhuang, ZP | 1 |
| Beach, TG; Fisher, A; Potter, PE; Sue, LI; Walker, DG | 1 |
| Gordon, DJ; Meredith, SC; Sciarretta, KL | 1 |
| Exley, C; Korchazhkina, OV | 1 |
| Mallory, M; Mante, M; Masliaha, E; Rockenstein, E; Sisk, A | 1 |
| Geula, C; Nagykery, N; Wu, CK | 1 |
| Fukushima, K; Isobe, Y; Kiuchi, Y | 1 |
| Hasegawa, K; Naiki, H; Ono, K; Takashima, A; Yamada, M; Yoshiike, Y | 2 |
| Kubo, T; Nishimura, S; Oda, T | 1 |
| Kaneko, I; Kogen, H; Koyama, K; Kubo, T; Marumoto, S; Meguro, M; Murasugi, T; Nakagami, Y; Nishimura, S; Oda, T | 2 |
| Borowski, BJ; Curran, GL; Jack, CR; Macura, SI; Poduslo, JF; Sigurdsson, EM; Wengenack, TM; Wisniewski, T | 1 |
| Gordon, DJ; Meredith, SC | 1 |
| Gur, TL; Hou, C; Kung, HF; Kung, MP; Lee, VM; Skovronsky, DM; Trojanowski, JQ; Zhang, B; Zhuang, ZP | 1 |
| Akagi, T; Chui, DH; Takashima, A; Tanaka, N; Yoshiike, Y | 1 |
| Debnath, ML; Holt, DP; Huang, GF; Klunk, WE; Mathis, CA; Wang, Y | 1 |
| Bardini, P; Danni, O; Guglielmotto, M; Marra, L; Parola, M; Santoro, G; Tabaton, M; Tamagno, E | 1 |
| Fernandez, EJ; Good, TA; Tobler, SA; Wang, SS | 1 |
| Babu-Khan, S; Biere, AL; Citron, M; Landreth, G; Liu, H; Vassar, R; Yan, Q; Zhang, J | 1 |
| Hou, C; Jin, LW; Kung, HF; Kung, MP; Zhuang, ZP | 1 |
| Biglieri, M; Bisaglia, M; Mancini, F; Milanese, C; Russo, C; Schettini, G; Venezia, V | 1 |
| Conte, A; Pellegrini, S; Tagliazucchi, D | 1 |
| Calissano, P; Ciotti, MT; Galli, C; Krasnowska, E; Romano, A; Ruberti, F; Serafino, A | 1 |
| Hasegawa, K; Naiki, H; Ono, K; Yamada, M | 1 |
| Hasegawa, K; Hayashi, H; Kimura, N; Lemere, CA; Matsuzaki, K; Michikawa, M; Naiki, H; Selkoe, DJ; Shibata, M; Terao, K; Yamaguchi, H; Yamamoto, N; Yanagisawa, K; Yokoseki, T; Yoshikawa, Y | 1 |
| Ding, J; Geng, M; Hu, J; Li, J; Tang, M; Wang, J; Xin, X; Zhang, J; Zhang, X | 1 |
| Moss, MA; Nichols, MR; Reed, DK; Rosenberry, TL; Varvel, NH | 1 |
| Cratic-McDaniel, S; Hoh, JH; Moss, MA; Nichols, MR; Reed, DK; Rosenberry, TL | 1 |
| Shivaprasad, S; Wetzel, R | 2 |
| Brown, J; Gee, AD; Hong, G; Judd, DB; Lockhart, A; Lowe, PN; Merritt, AT; Morgenstern, JL; Ye, L | 1 |
| Chilcote, T; Cunningham, D; Powell, K; Rydel, RE; Wogulis, M; Wright, S | 1 |
| Dahlqvist, C; Ito, A; Kakuyama, H; Näslund, J; Söderberg, L; Thyberg, J; Tjernberg, LO; Winblad, B | 1 |
| Akasofu, S; Kimura, M; Ogura, H; Sawada, K | 1 |
| Christopeit, T; Fändrich, M; Hortschansky, P; Schroeckh, V; Zandomeneghi, G | 1 |
| Beard, J; Das, P; DeLucia, M; Dickson, DW; Dolios, G; Eckman, CB; Eriksen, J; Golde, T; Hardy, J; Hutton, M; Jansen, K; Kim, J; Lin, WL; McGowan, E; Murphy, MP; Onstead, L; Pickford, F; Skipper, L; Wang, R; Yu, C | 1 |
| Hecht, MH; Kim, W | 1 |
| Crisby, M; Lindberg, C; Schultzberg, M; Winblad, B | 1 |
| Kheterpal, I; O'Nuallain, B; Shivaprasad, S; Wetzel, R | 1 |
| Cardoso, SM; Oliveira, CR; Pereira, C; Rego, AC | 1 |
| Iwasa, K; Matsumoto, Y; Naiki, H; Noguchi, M; Ono, K; Yamada, M; Yanase, D | 1 |
| Ahmed, M; Aimoto, S; Constantinescu, SN; Elliott, JI; Kienlen-Campard, P; Li, H; Liu, W; Octave, JN; Sato, T; Smith, SO | 1 |
| Amijee, H; Doig, AJ; Kokkoni, N; Mason, JM; Stott, K | 1 |
| Ban, T; Goto, Y | 1 |
| Howlett, GJ; Mok, YF | 1 |
| Glabe, CG; Kayed, R | 1 |
| Bourhim, M; Kruzel, M; Nicotera, T; Srikrishnan, T | 1 |
| Grubb, A; Ostergaard-Pedersen, L; Selenica, ML; Wang, X; Westlind-Danielsson, A | 1 |
| Bojsen-Møller, M; Braendgaard, H; Frangione, B; Ghiso, J; Holton, J; Lashley, T; Meyerson, J; Ng, D; Plant, G; Revesz, T; Rostagno, A | 1 |
| Ikeda, K; Matsuzaki, K; Okada, T; Wakabayashi, M | 1 |
| Akagi, T; Takashima, A; Yoshiike, Y | 1 |
| Benseny-Cases, N; Cladera, J; Cócera, M | 1 |
| Aizezi, B; Calero, DC; Chimon, S; Ishii, Y; Jones, CR; Shaibat, MA | 1 |
| Freir, DB; Herron, CE; Schmid, AW | 1 |
| Anderson, L; Murphy, GM; Parvathy, S; Rajadas, J; Ryan, H; Vaziri, S | 1 |
| Gokce, O; Jan, A; Lashuel, HA; Luthi-Carter, R | 1 |
| Arai, H; Fujiwara, H; Gamoh, S; Hashimoto, M; Katakura, M; Miyazawa, T; Shahdat, HM; Shido, O; Shimada, T; Tanabe, Y; Yamashita, S | 1 |
| Demeler, B; Hochdörffer, K; Meyer-Zaika, W; Nagel-Steger, L; Schrader, T; Willbold, D | 1 |
| Levine, H; Rosen, RF; Walker, LC | 1 |
| Meredith, SC; Orgel, JP; Sciarretta, KL; Tycko, R | 1 |
| Fonseca, AC; Oliveira, CR; Pereira, CM; Proença, T; Resende, R | 1 |
| Bero, AW; Csernansky, JG; Dong, H; Holtzman, DM; Kling, MJ; Timson, BF; Yuede, CM; Zimmerman, SD | 1 |
| Maiti, S; Nag, S; Sahoo, B; Sengupta, P | 1 |
| Durany, N; Fernàndez-Busquets, X; Gella, A; Unzeta, M; Valente, T | 1 |
| Chan, WH; Choi, MM; Li, HW; Xiao, L; Zhao, D | 1 |
| Bitan, G; Chen, CH; Murakami, K; Rahimi, F; Summers, JL | 1 |
| Bradley, J; Mayne, M; Noonan, C; Richard, K; Supnet, C | 1 |
| Ajit, D; Gallazzi, F; Nichols, MR; Touchette, JC; Williams, LL | 1 |
| Goto, Y; Hasegawa, K; Morinaga, A; Naiki, H; Nomura, R; Ookoshi, T; Ozawa, D; Yamada, M | 1 |
| Aliano, R; Campagna, F; Carotti, A; Catto, M; Cellamare, S; De Stradis, A; Palluotto, F; Purgatorio, R | 1 |
| Gilman, SD; Kheterpal, I; Moses, JP; Picou, R; Wellman, AD | 1 |
| Goto, Y; Huong, VT; Kuboi, R; Shimanouchi, T; Shimauchi, N; Umakoshi, H; Yagi, H | 1 |
| Hu, YE; Mao, JH; Shi, HY; Zhou, AL; Zhu, Y | 1 |
| Baban, B; Crick, SL; Frieden, C; Garai, K; Mustafi, SM | 1 |
| Bartic, C; Benilova, I; Braeken, D; Broersen, K; Callewaert, G; D'Hooge, R; De Strooper, B; Debulpaep, M; Jonckheere, W; Kuperstein, I; Martins, IC; Rousseau, F; Rozenski, J; Schymkowitz, J; Segers-Nolten, I; Subramaniam, V; Van Der Werf, K; Vandersteen, A | 1 |
| Altomare, CD; Campagna, F; Carotti, A; Catto, M; De Stradis, A; Palazzo, G; Purgatorio, R | 1 |
| Bastone, A; Beeg, M; Gobbi, M; Salmona, M; Stravalaci, M | 1 |
| Cloe, AL; Meredith, SC; Orgel, JP; Sachleben, JR; Tycko, R | 1 |
| Flashner, E; Friedler, A; Raviv, U | 1 |
| Fukunishi, Y; Fukushima, M; Goto, Y; Hirao, M; Ogi, H; Uesugi, K; Yagi, H; Yanagida, T | 1 |
| Bao, F; Klein, WL; Lacor, PN; Marutle, A; Nordberg, A; Wicklund, L | 1 |
| Arduino, DM; Cardoso, SM; Esteves, AR; Oliveira, CR; Silva, DF | 1 |
| Cardoso, SM; Costa, RO; Ferreiro, E; Martins, I; Oliveira, CR; Pereira, CM; Santana, I | 1 |
| Devanand, DP; Mayeux, R; Mehta, P; Parsey, R; Pelton, GH; Schupf, N; Stern, Y | 1 |
| Bian, JS; Del Soldato, P; Liu, YY; Sparatore, A | 1 |
| Bitan, G; Bowers, MT; Gessel, MM; Li, H; Shea, JE; Wu, C | 1 |
| Biagio, PL; Bulone, D; Canale, C; Carrotta, R; Diaspro, A; Trapani, A | 1 |
| Harvey, BS; Mååg, JL; Musgrave, IF; Ohlsson, KS; Smid, SD | 1 |
| Chaudhary, N; Nagaraj, R; Pachahara, SK; Subbalakshmi, C | 1 |
| Cerqua, RA; Gilman, SD; Kheterpal, I; Ku, G; Picou, RA; Schrum, DP | 1 |
| Acton, P; Babu-Khan, S; Bartberger, MD; Brown, J; Chen, K; Cheng, Y; Citron, M; Croghan, MD; Dineen, TA; Dunn, RT; Esmay, J; Graceffa, RF; Harried, SS; Hickman, D; Hitchcock, SA; Horne, DB; Huang, H; Imbeah-Ampiah, R; Judd, T; Kaller, MR; Kreiman, CR; La, DS; Li, V; Lopez, P; Louie, S; Monenschein, H; Nguyen, TT; Patel, VF; Pennington, LD; San Miguel, T; Sickmier, EA; Vargas, HM; Wahl, RC; Weiss, MM; Wen, PH; Whittington, DA; Williamson, T; Wood, S; Xue, Q; Yang, BH; Zhong, W | 1 |
| Jan, A; Lashuel, HA | 1 |
| Duarte, FS; Piermartiri, TC; Prediger, RD; Rial, D; Tasca, CI; Walz, R | 1 |
| Hirohata, M; Ikeda, T; Morinaga, A; Ono, K; Takahashi, R; Takasaki, J; Yamada, M | 1 |
| Keene, CD; Li, X; Montine, KS; Montine, TJ; Rose, SE | 1 |
| Ikeda, T; Ono, K; Takahashi, R; Yamada, M | 1 |
| Cabaleiro-Lago, C; Dawson, KA; Linse, S; Lynch, I; Quinlan-Pluck, F | 1 |
| Gan, CS; Pan, J; Wang, HS; Zhao, ZZ; Zhou, L | 1 |
| Cheng, XR; Hau, BY; Kerman, K; Kraatz, HB; Martic, S; Veloso, AJ | 1 |
| Debnath, ML; Klunk, WE; Lin, KS; Mason, NS; Mathis, CA; Pan, J | 1 |
| Garvey, M; Morgado, I | 1 |
| Aisen, PS; Foroud, T; Inlow, M; Jagust, WJ; Kim, S; Koeppe, RA; Mathis, CA; Petersen, RC; Risacher, SL; Saykin, AJ; Shaw, LM; Shen, L; Soares, H; Swaminathan, S; Trojanowski, JQ; Weiner, MW; West, JD; Yoder, KK | 1 |
| Hedden, T; Oh, H; Patel, TA; Younger, AP | 1 |
| Belfort, G; Bitan, G; Connors, CR; Garcia, A; Lopes, DH; Mittal, S; Rosenman, DJ; Sorci, M; Wang, C | 1 |
| Kapurniotu, A; Velkova, A; Yan, LM | 1 |
| Bergfors, A; Gillberg, PG; Marutle, A; Ni, R; Nordberg, A | 1 |
| Deng, M; Han, Y; He, C; Wang, Y; Zhu, L | 1 |
| Bieschke, J; Kelly, JW; Murray, AN; Palhano, FL | 1 |
| Abrahams, JP; Gräslund, A; Luo, J; Otero, JM; Overhand, M; Wärmländer, SK; Yu, CH | 1 |
| Geraldes, CF; Martins, AF; Morfin, JF; Tóth, E | 1 |
| Cheng, S; Li, Y; Mobley, WC; Nguyen, P; Rynearson, KD; Sisodia, SS; Tanzi, RE; Wagner, SL; Wang, R; Zhang, C; Zhang, X | 1 |
| Bhave, O; Lutz-Rechtin, T; Moore, KA; Moss, MA; Rogers, L; Servoss, SL; Turner, JP | 1 |
| Chen, TF; Cheng, TW; Chiu, MJ; Horng, HE; Huang, YY; Shiue, CY; Tzen, KY; Wen, HP; Yang, SY | 1 |
| Furuta, A; Imagawa, H; Matsunaga, Y; Ouma, S; Suenaga, M; Takahashi, H; Tsuboi, Y; Wagatsuma, M | 1 |
| Bartic, C; Benilova, I; Castillo Cano, V; De Strooper, B; Gallardo, R; Ramakers, M; Rousseau, F; Schymkowitz, J; Snellinx, A; Ungureanu, AA | 1 |
| Elmaleh, DR; Li, Y; Moore, A; Ran, C; Shoup, TM; Teng, X; Tian, Y; Zhang, X | 1 |
| Fukukshima, M; Goto, Y; Hamada, H; Hirao, M; Noi, K; Ogi, H; Yagi, H | 1 |
| Esbjörner, EK; Gilbert Gatty, M; Lindberg, DJ; Westerlund, F; Wranne, MS | 1 |
| Dias, DM; Geraldes, CF; Lacerda, S; Laurents, DV; Martins, AF; Morfin, JF; Tóth, É | 1 |
| Chen, YX; Li, YM; Liu, Q; Qiu, T; Zhao, YF | 1 |
| Di Carlo, MG; Foderà, V; Leone, M; Militello, V; Minicozzi, V; Morante, S; Vetri, V | 1 |
| Benzinger, TL; Brix, B; Darby, HD; Fagan, AM; Holtzman, DM; Jasielec, MS; Ladenson, JH; Macy, EM; Morris, JC; Shah, AR; Stoops, EE; Sutphen, CL; Vanderstichele, HM; Vandijck, ML; Vlassenko, AG; Xiong, C | 1 |
| Adachi, T; Hongo, K; Ichino, H; Kawata, Y; Kobayashi, S; Mizobata, T; Nakanishi, M; Nakashima, K; Uchino, K; Watanabe, Y; Yamakawa, MY | 1 |
| Lahiri, DK; Paule, MG; Ray, B; Raymick, J; Sarkar, S; Schmued, L | 1 |
| Gräslund, A; Jarvet, J; Tiiman, A; Vukojević, V | 1 |
| Fosso, MY; Garneau-Tsodikova, S; Head, E; LeVine, H; McCarty, K | 1 |
| Gu, M; Viles, JH | 1 |
| Chang, CW; Chen, RP; Chen, ZT; Cheng, YS; Liao, TY; Lin, C; Lin, CY; Liu, RS; Tan, DT; Tu, PH; Twu, WI | 1 |
| André, I; Faller, P; Gras, E; Hoarau, M; Hureau, C; Irague, R; Malbert, Y; Remaud-Siméon, M | 1 |
| Hiramatsu, H; Osaki, D | 1 |
| Blennow, K; Eusebi, P; Fagan, AM; Kornhuber, J; Lewczuk, P; Matzen, A; Molinuevo, JL; Morris, JC; Parnetti, L | 1 |
| Byun, MS; Cho, HJ; Choe, YM; Han, SH; Jung, ES; Kang, S; Kim, EH; Kim, YK; Lee, DY; Mook-Jung, I; Park, JC; Won, SJ; Yi, D | 1 |
| Contreras-García, J; Guallar, V; Pantaleone, S; Peccati, F; Riffet, V; Sodupe, M; Solans-Monfort, X | 1 |
| Diner, I; Dooyema, J; Gearing, M; Seyfried, NT; Walker, LC | 1 |
| Ishii, Y; McElheny, D; Xiao, Y; Yoo, BK | 1 |
| Batrla-Utermann, R; Benzinger, TLS; Fagan, AM; Gordon, BA; Gray, JD; Holtzman, DM; Morris, JC; Quan, M; Schindler, SE; Wahl, S; Xiong, C | 1 |
| Bellomo, G; Bologna, S; Fragai, M; Gonnelli, L; Lelli, M; Luchinat, C; Ravera, E | 1 |
| Arbizu, J; Boada, M; Martínez-Lage, P; Monleón, I; Munuera, J; Pérez-Grijalba, V; Pesini, P; Romero, J; Ruiz, A; San-José, I; Sarasa, L; Sarasa, M; Tárraga, L | 1 |
| Agnati, LF; Andreoli, N; Astancolle, S; Carone, C; Davalli, P; Filaferro, M; Fuxe, K; Genedani, S; Leo, G | 1 |
| Cai, HC; Cheng, DF; Han, YJ; Lei, B; Wang, J; Wu, MX; Yin, DZ; Zhang, H; Zhang, L; Zheng, MQ | 1 |
| Jiji, RD; Wang, M | 1 |
3 review(s) available for thiazoles and amyloid beta-peptides
| Article | Year |
|---|---|
Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro.
Topics: Amyloid beta-Peptides; Animals; Blotting, Western; Calcium Channel Blockers; Cell Line, Tumor; Cells, Cultured; Coloring Agents; Dinoprostone; Humans; Hydrazines; Mice; Mice, Inbred C57BL; Neurons; Neurotoxicity Syndromes; Nimodipine; Oxazepines; Peptide Fragments; Prostaglandin Antagonists; Receptors, Prostaglandin E, EP1 Subtype; Tetrazolium Salts; Thiazoles | 2013 |
Meta-analysis of amyloid-cognition relations in cognitively normal older adults.
Topics: Aging; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Cognition; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Female; Humans; Male; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; Thiazoles | 2013 |
Aβ42 and Aβ40: similarities and differences.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Antibodies, Monoclonal; Brain Chemistry; Humans; Molecular Probes; Molecular Sequence Data; Peptide Fragments; Protein Aggregation, Pathological; Protein Structure, Secondary; Proteolysis; Styrenes; Thiazoles | 2015 |
170 other study(ies) available for thiazoles and amyloid beta-peptides
| Article | Year |
|---|---|
Conformational restriction via cyclization in beta-amyloid peptide Abeta(1-28) leads to an inhibitor of Abeta(1-28) amyloidogenesis and cytotoxicity.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Cell Survival; Chromatography, Gel; Circular Dichroism; Congo Red; Cyclization; Drug Design; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Conformation; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2003 |
Aluminum promotes the aggregation of Alzheimer's amyloid beta-protein in vitro.
Topics: Aluminum Chloride; Aluminum Compounds; Amyloid beta-Peptides; Benzothiazoles; Chemical Precipitation; Chlorides; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Immunoblotting; Peptide Fragments; Staining and Labeling; Thiazoles | 1994 |
Amyloid beta protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid beta protein.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Hippocampus; Neurons; Peptide Fragments; Rats; Substance P; Tetrazolium Salts; Thiazoles | 1994 |
Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of beta-amyloid in rat PC12 cells.
Topics: Amyloid beta-Peptides; Animals; Cell Survival; Coloring Agents; Glycosaminoglycans; Oxidation-Reduction; PC12 Cells; Peptide Fragments; Rats; Tetrazolium Salts; Thiazoles | 1995 |
Glycosaminoglycans and sulphated polyanions attenuate the neurotoxic effects of beta-amyloid.
Topics: Amyloid beta-Peptides; Animals; Cell Survival; Coloring Agents; Congo Red; Dose-Response Relationship, Drug; Glycosaminoglycans; Neurotoxins; PC12 Cells; Peptide Fragments; Rats; Tetrazolium Salts; Thiazoles | 1995 |
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Peptide Fragments; Temperature; Thiazoles | 1996 |
Amyloid beta-mediated oxidative and metabolic stress in rat cortical neurons: no direct evidence for a role for H2O2 generation.
Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzothiazoles; Catalase; Cell Survival; Cells, Cultured; Cerebral Cortex; Coloring Agents; Fetus; Fluoresceins; Free Radical Scavengers; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Glyoxylates; Hydrogen Peroxide; L-Lactate Dehydrogenase; Neurons; Neurotoxins; Oxazines; Oxidative Stress; Peptide Fragments; Rats; Reactive Oxygen Species; Thiazoles; Xanthenes | 1996 |
Amyloid beta toxicity consists of a Ca(2+)-independent early phase and a Ca(2+)-dependent late phase.
Topics: Amyloid beta-Peptides; Animals; Calcium; Cell Death; Coloring Agents; Embryo, Mammalian; Glutamic Acid; Hippocampus; Kinetics; L-Lactate Dehydrogenase; Neurons; Neurotoxins; Oxidation-Reduction; Peptide Fragments; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors | 1996 |
Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Carnosine; Cognition; Cross-Linking Reagents; Fructose; Glycation End Products, Advanced; Guanidines; Humans; Memory; Neuropeptide Y; Particle Size; Peptide Fragments; Piperazines; Protein Structure, Secondary; Solubility; Temperature; Thiazoles; Thiophenes | 1997 |
Stopped-flow kinetics reveal multiple phases of thioflavin T binding to Alzheimer beta (1-40) amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Sequence Data; Molecular Structure; Naphthalenesulfonates; Osmolar Concentration; Peptide Fragments; Protein Binding; Protein Conformation; Protein Structure, Secondary; Sodium Chloride; Temperature; Thiazoles | 1997 |
Aggregation state-dependent activation of the classical complement pathway by the amyloid beta peptide.
Topics: Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Complement Activation; Congo Red; Fluorescent Dyes; Humans; Microscopy, Electron; Peptide Fragments; Thiazoles | 1997 |
Congo red reverses amyloid beta protein-induced cellular stress in astrocytes.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Cells, Cultured; Congo Red; Oxidation-Reduction; Peptide Fragments; Rats; Rats, Wistar; Stress, Physiological; Tetrazolium Salts; Thiazoles; Time Factors | 1997 |
Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells.
Topics: Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Cell Membrane; Cells, Cultured; Cerebral Hemorrhage; Cerebrovascular Circulation; Circular Dichroism; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; Immunoblotting; Microscopy, Electron; Muscle, Smooth, Vascular; Mutation; Peptide Fragments; Thiazoles | 1998 |
Amyloid beta-peptide-induced inhibition of MTT reduction in PC12h and C1300 neuroblastoma cells: effect of nitroprusside.
Topics: Amyloid beta-Peptides; Animals; L-Lactate Dehydrogenase; Mice; Neuroblastoma; Nitric Oxide; Nitroprusside; Oxidation-Reduction; PC12 Cells; Peptide Fragments; Rats; Sodium Glutamate; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1998 |
Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation.
Topics: alpha-Macroglobulins; Amyloid beta-Peptides; Benzothiazoles; Biotinylation; DNA, Complementary; HeLa Cells; Humans; Neurofibrils; Peptide Fragments; Precipitin Tests; Protease Inhibitors; Protein Binding; Thiazoles | 1998 |
The neurotoxicity of amyloid beta protein in aged primates.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Antigens; Benzothiazoles; Brain; Female; Haplorhini; Immunohistochemistry; Male; Microinjections; Microscopy, Fluorescence; Neurons; Peptide Fragments; Thiazoles; Ubiquitins | 1998 |
Laminin blocks the assembly of wild-type A beta and the Dutch variant peptide into Alzheimer's fibrils.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Fluorescence; Kinetics; Laminin; Nephelometry and Turbidimetry; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles | 1998 |
Amyloid beta-peptide (1-40)-mediated oxidative stress in cultured hippocampal neurons. Protein carbonyl formation, CK BB expression, and the level of Cu, Zn, and Mn SOD mRNA.
Topics: Amyloid beta-Peptides; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Creatine Kinase; Hippocampus; Humans; Isoenzymes; Mitochondria; Neurons; Oxidative Stress; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Trypan Blue | 1998 |
Characterization of 8-epiprostaglandin F2alpha as a marker of amyloid beta-peptide-induced oxidative damage.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Biomarkers; Cell Survival; Cells, Cultured; Dinoprost; F2-Isoprostanes; Fluorescent Dyes; Hippocampus; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Lipid Peroxidation; Neurons; Oxidants; Oxidative Stress; Peptide Fragments; Protein Conformation; Rats; Thiazoles | 1999 |
Laminin inhibits both Abeta40 and Abeta42 fibril formation but does not affect Abeta40 or Abeta42-induced cytotoxicity in PC12 cells.
Topics: Amyloid beta-Peptides; Animals; Cell Survival; Coloring Agents; Laminin; PC12 Cells; Peptide Fragments; Rats; Tetrazolium Salts; Thiazoles | 1999 |
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Peptide Fragments; Plaque, Amyloid; Reference Values; Solubility; Thiazoles | 1999 |
The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Crystallins; Dose-Response Relationship, Drug; Hippocampus; Molecular Chaperones; Neurons; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Structure, Secondary; Rats; Thiazoles | 1999 |
Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells.
Topics: Amyloid beta-Peptides; Cell Survival; Drug Combinations; Glutathione; Melatonin; Mercuric Chloride; Neuroblastoma; Oxidative Stress; Peptide Fragments; Phosphorylation; tau Proteins; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2000 |
Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Brain; Cell Differentiation; Chromans; Cyclooxygenase 2; Dinoprost; Genes, Reporter; Humans; Inflammation; Interleukin-6; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Microbodies; Microglia; Monocytes; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
A possible model of senile plaques using synthetic amyloid beta-protein and rat glial culture.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Cells, Cultured; Coloring Agents; Congo Red; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Histocompatibility Antigens Class II; Image Processing, Computer-Assisted; Interleukin-1; Microglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Staining and Labeling; Thiazoles | 2000 |
Novel proline endopeptidase inhibitors do not modify Abeta40/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein.
Topics: Amyloid beta-Peptides; Cells, Cultured; Humans; Indoles; Peptide Fragments; Prolyl Oligopeptidases; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Thiazolidines | 2000 |
Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain.
Topics: Amyloid; Amyloid beta-Peptides; Basement Membrane; Benzothiazoles; Binding Sites; Dose-Response Relationship, Drug; Fluorometry; Immunoassay; Islet Amyloid Polypeptide; Laminin; Microscopy, Electron; Negative Staining; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid; Thiazoles | 2000 |
N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation.
Topics: Acetylcysteine; Amyloid beta-Peptides; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutathione; Glutathione Reductase; Humans; Hydrogen Peroxide; Neuroblastoma; Oxidative Stress; Peptide Fragments; Phosphorylation; tau Proteins; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Ultraviolet Rays | 2001 |
Spectroscopic evidence for amyloid-like interfacial self-assembly of hydrophobin Sc3.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cattle; Congo Red; Fungal Proteins; Peptide Fragments; Protein Structure, Secondary; Schizophyllum; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry; Thiazoles | 2001 |
The relationship between Abeta-associated free radical generation and Abeta fibril formation revealed by negative stain electron microscopy and thioflavine-T fluorometric assay.
Topics: Amyloid beta-Peptides; Benzothiazoles; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Fluorometry; Free Radicals; Microscopy, Electron; Negative Staining; Peptide Fragments; Thiazoles | 2001 |
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Benzene Derivatives; Blood-Brain Barrier; Brain; Down Syndrome; Humans; Indicators and Reagents; Iodine Radioisotopes; Isotope Labeling; Kinetics; Ligands; Mice; Peptide Fragments; Structure-Activity Relationship; Styrenes; Thiazoles; Tissue Distribution | 2001 |
Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrospinal Fluid; Female; Muscarinic Agonists; Neurons; Peptide Fragments; Piperidines; Quinuclidines; Rabbits; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiazoles; Thiophenes | 2001 |
Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acids; Amyloid beta-Peptides; Benzothiazoles; Chymotrypsin; Drug Resistance; Humans; Methylation; Microscopy, Fluorescence; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; Thiazoles; Ultracentrifugation | 2001 |
Plasmin cleaves Abeta42 in vitro and prevents its aggregation into beta-pleated sheet structures.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Fibrinolysin; Humans; Peptide Fragments; Protein Structure, Secondary; Thiazoles | 2001 |
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Congo Red; Disease Models, Animal; Gene Expression Regulation, Developmental; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Insertional; Mutation; Neurites; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; Promoter Regions, Genetic; Thiazoles | 2001 |
Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition.
Topics: Aging; alpha 1-Antichymotrypsin; Amyloid beta-Peptides; Animals; Apolipoproteins E; Benzothiazoles; Brain Diseases; Callithrix; Cerebral Cortex; Cholinesterases; Disease Models, Animal; Female; Incidence; Male; Neurites; Peptide Fragments; Plaque, Amyloid; Survival Analysis; Thiazoles | 2002 |
Type IV collagen prevents amyloid beta-protein fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Collagen Type IV; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Microscopy, Electron; Peptide Fragments; Spectrometry, Fluorescence; Thiazoles | 2002 |
Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Kidney; Macromolecular Substances; Masoprocol; Microscopy, Electron; Peptide Fragments; Protein Binding; Spectrometry, Fluorescence; Thiazoles | 2002 |
Amyloid beta-peptide alters the distribution of early endosomes and inhibits phosphorylation of Akt in the presence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT).
Topics: Amyloid beta-Peptides; Antibodies; Biomarkers; Chromones; Coloring Agents; Endosomes; Enzyme Inhibitors; HeLa Cells; Humans; Immunohistochemistry; Membrane Proteins; Mitogen-Activated Protein Kinases; Morpholines; Oxidation-Reduction; Peptide Fragments; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rab5 GTP-Binding Proteins; Tetrazolium Salts; Thiazoles; Vesicular Transport Proteins | 2002 |
A novel compound RS-0466 reverses beta-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro.
Topics: Amyloid beta-Peptides; Animals; Cells, Cultured; Coloring Agents; Excitatory Postsynaptic Potentials; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Neurons; Peptide Fragments; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Triazines | 2002 |
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Gadolinium; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Transgenic; Molecular Probe Techniques; Neurons; Peptide Fragments; Plaque, Amyloid; Predictive Value of Tests; Presenilin-1; Putrescine; Reproducibility of Results; Thiazoles | 2002 |
Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Congo Red; Cross-Linking Reagents; Diphenylhexatriene; Esters; Fluorescent Dyes; Humans; Hydrogen Bonding; Molecular Sequence Data; Peptide Fragments; Phenylalanine; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Ultracentrifugation | 2003 |
Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Artifacts; Binding, Competitive; Blood-Brain Barrier; Brain; Humans; Immunohistochemistry; Iodine Radioisotopes; Mice; Mice, Transgenic; Nerve Fibers, Myelinated; Peptide Fragments; Plaque, Amyloid; Radionuclide Imaging; Reproducibility of Results; Styrenes; Thiazoles | 2003 |
Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Dimerization; Genetic Variation; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Peptide Fragments; Static Electricity; Thiazoles | 2003 |
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.
Topics: Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Carbon Radioisotopes; Female; In Vitro Techniques; Isotope Labeling; Male; Mice; Papio; Peptide Fragments; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed | 2003 |
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.
Topics: Acetylcysteine; alpha-Tocopherol; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cell Differentiation; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
RS-4252 inhibits amyloid beta-induced cytotoxicity in HeLa cells.
Topics: Amyloid beta-Peptides; Chromans; HeLa Cells; Humans; Oxidation-Reduction; Peptide Fragments; Phenols; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetrazolium Salts; Thiazoles; Triazines | 2003 |
Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure.
Topics: Amyloid beta-Peptides; Benzothiazoles; Congo Red; Fluorescence; Humans; Hydrogen; Hydrophobic and Hydrophilic Interactions; Peptide Fragments; Protein Structure, Tertiary; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2003 |
Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Humans; Ibuprofen; Mice; Mice, Transgenic; Microglia; Peptide Fragments; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Flavonoids; Humans; Kidney; Kinetics; Microscopy, Electron; Peptide Fragments; Phenols; Polymers; Quercetin; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2003 |
Characterization of radioiodinated ligand binding to amyloid beta plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Brain; Humans; Iodine Radioisotopes; Ligands; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Plaque, Amyloid; Pyrazoles; Pyridines; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2003 |
alpha-Glycerylphosphorylethanolamine rescues astrocytes from mitochondrial impairment and oxidative stress induced by amyloid beta-peptides.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Cell Membrane; Cells, Cultured; Gliosis; Lipid Peroxidation; Membrane Fluidity; Membrane Potentials; Microscopy, Confocal; Mitochondria; Nerve Degeneration; Oxidative Stress; Peptide Fragments; Phosphatidylethanolamines; Rats; Tetrazolium Salts; Thiazoles | 2004 |
Synergistic protection of PC12 cells from beta-amyloid toxicity by resveratrol and catechin.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Catechin; Cell Count; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Lipid Peroxidation; PC12 Cells; Peptide Fragments; Rats; Resveratrol; Stilbenes; Tetrazolium Salts; Thiazoles; Thiobarbiturates | 2003 |
Neuronal fibrillogenesis: amyloid fibrils from primary neuronal cultures impair long-term memory in the crab Chasmagnathus.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Benzothiazoles; Brachyura; Cells, Cultured; Cerebellum; Culture Media, Conditioned; Dose-Response Relationship, Drug; Fluorometry; Immunohistochemistry; Male; Memory; Microscopy, Electron; Neurons; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Thiazoles; Time Factors | 2003 |
Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Cinnamates; Curcumin; Depsides; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Lipoxygenase Inhibitors; Masoprocol; Microscopy, Electron; Microscopy, Polarization; Neurofibrillary Tangles; Peptide Fragments; Platelet Aggregation Inhibitors; Rosmarinic Acid; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2004 |
A seed for Alzheimer amyloid in the brain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibody Specificity; Benzothiazoles; Brain; Brain Chemistry; Cell Survival; Cells, Cultured; G(M1) Ganglioside; Humans; Liposomes; Macaca fascicularis; Macromolecular Substances; Microscopy, Immunoelectron; Middle Aged; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors | 2004 |
Acidic oligosaccharide sugar chain, a marine-derived acidic oligosaccharide, inhibits the cytotoxicity and aggregation of amyloid beta protein.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Calcium; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebral Cortex; Humans; Lipid Peroxidation; Membrane Potentials; Mitochondria; Peptide Fragments; Phaeophyceae; Rats; Tetrazolium Salts; Thiazoles; Thiobarbituric Acid Reactive Substances | 2004 |
Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Fluorescence; Humans; Masoprocol; Peptide Fragments; Thiazoles | 2004 |
Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biochemistry; Chromatography; Circular Dichroism; Humans; Ions; Kinetics; Light; Microscopy, Atomic Force; Microscopy, Electron; Peptide Fragments; Propanols; Protein Conformation; Scattering, Radiation; Thiazoles; Time Factors | 2005 |
An intersheet packing interaction in A beta fibrils mapped by disulfide cross-linking.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Cross-Linking Reagents; Cysteine; Disulfides; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles | 2004 |
Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Binding, Competitive; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Humans; Kinetics; Ligands; Models, Biological; Models, Chemical; Peptide Fragments; Peptides; Positron-Emission Tomography; Protein Binding; Spectrometry, Fluorescence; Thiazoles | 2005 |
Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.
Topics: Amyloid; Amyloid beta-Peptides; Artifacts; Biopolymers; Cell Death; Cell Membrane Permeability; Cells, Cultured; Cerebral Cortex; Coloring Agents; Crystallization; Formazans; Humans; Islet Amyloid Polypeptide; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Models, Chemical; Neurons; Oxidation-Reduction; Peptide Fragments; Solubility; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles | 2005 |
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Nerve Tissue Proteins; Non-Fibrillar Collagens; Peptide Fragments; Thiazoles | 2005 |
Protective effect of donepezil against Abeta(1-40) neurotoxicity in rat septal neurons.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Down-Regulation; Fluorescent Dyes; Immunohistochemistry; Indans; L-Lactate Dehydrogenase; Membrane Transport Proteins; Molecular Structure; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Septal Nuclei; Thiazoles; Vesicular Acetylcholine Transport Proteins | 2005 |
The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Computer Simulation; Endopeptidases; Histidine; Humans; Kinetics; Mutation; Peptide Fragments; Protein Conformation; Protein Folding; Solubility; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2005 |
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Topics: Age Factors; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Blood Vessels; Blotting, Northern; Blotting, Western; Brain; Cerebral Amyloid Angiopathy; Enzyme-Linked Immunosorbent Assay; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Immunoprecipitation; In Situ Hybridization; Male; Mass Spectrometry; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Mutation; Peptide Fragments; Pia Mater; Plaque, Amyloid; Thiazoles | 2005 |
Multiple ligand binding sites on A beta(1-40) fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Fluorescent Dyes; Humans; Ibuprofen; Ligands; Models, Chemical; Molecular Structure; Naproxen; Peptide Fragments; Protein Binding; Thiazoles | 2005 |
Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biophysical Phenomena; Biophysics; Chromatography, High Pressure Liquid; DNA Primers; Green Fluorescent Proteins; Humans; Kinetics; Microscopy, Fluorescence; Models, Chemical; Mutation; Peptide Fragments; Peptide Library; Peptides; Phenotype; Protein Structure, Secondary; Recombinant Fusion Proteins; Sequence Analysis, Protein; Temperature; Thiazoles; Time Factors | 2005 |
Effects of statins on microglia.
Topics: Amyloid beta-Peptides; Animals; Atorvastatin; Cell Death; Cell Line; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; L-Lactate Dehydrogenase; Lipopolysaccharides; Microglia; Peptide Fragments; Pyrroles; Rats; Simvastatin; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles | 2005 |
Thermodynamics of A beta(1-40) amyloid fibril elongation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Chromatography, High Pressure Liquid; Deuterium Exchange Measurement; Kinetics; Peptide Fragments; Point Mutation; Protein Folding; Thermodynamics; Thiazoles | 2005 |
Protective effect of zinc on amyloid-beta 25-35 and 1-40 mediated toxicity.
Topics: Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Cell Line; Coloring Agents; Congo Red; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Microscopy, Confocal; Mitochondria; Neurotoxins; Peptide Fragments; Protein Structure, Secondary; Thiazoles; Zinc | 2005 |
Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebrospinal Fluid; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Middle Aged; Peptide Fragments; Plaque, Amyloid; Polymers; Thiazoles | 2005 |
Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Chromatography, High Pressure Liquid; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Humans; Hydrocarbons, Iodinated; Iodoacetic Acid; Kinetics; Microscopy, Electron; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation; Peptide Fragments; Peptide Mapping; Peptides; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Solvents; Thermodynamics; Thiazoles; Time Factors | 2006 |
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Fluorescent Dyes; Glycine; Humans; Methionine; Microscopy, Electron; Molecular Sequence Data; Neurons; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Spectrometry, Fluorescence; Thiazoles | 2006 |
N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Chromatography, Affinity; Molecular Sequence Data; Oligopeptides; PC12 Cells; Peptide Fragments; Peptide Library; Peptides; Protein Structure, Quaternary; Rats; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Toxicity Tests | 2006 |
Direct observation of amyloid growth monitored by total internal reflection fluorescence microscopy.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Microscopy, Fluorescence; Peptide Fragments; Thiazoles | 2006 |
Sedimentation velocity analysis of amyloid oligomers and fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Centrifugation; Humans; Peptide Fragments; Protein Structure, Quaternary; Thiazoles; Ultracentrifugation | 2006 |
Conformation-dependent anti-amyloid oligomer antibodies.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Animals; Antibodies; Benzothiazoles; Circular Dichroism; Epitopes; Humans; Molecular Mimicry; Molecular Sequence Data; Neurodegenerative Diseases; Peptide Fragments; Protein Conformation; Protein Structure, Quaternary; Rabbits; Thiazoles | 2006 |
Linear quantitation of Abeta aggregation using Thioflavin T: reduction in fibril formation by colostrinin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biological Assay; Biomarkers; Dose-Response Relationship, Drug; Down-Regulation; Fluorescence; Fluorescent Dyes; Humans; Intercellular Signaling Peptides and Proteins; Linear Models; Microscopy, Fluorescence; Molecular Weight; Neurochemistry; Neuroprotective Agents; Peptide Fragments; Peptides; Plaque, Amyloid; Solubility; Thiazoles | 2007 |
Cystatin C reduces the in vitro formation of soluble Abeta1-42 oligomers and protofibrils.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Chromatography, Gel; Cystatin C; Cystatins; Electrophoresis, Polyacrylamide Gel; Immunoblotting; In Vitro Techniques; Microscopy, Electron, Transmission; Peptide Fragments; Protease Inhibitors; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2007 |
Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Aged; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Amyloid Angiopathy, Familial; Dementia; Denmark; England; Humans; Immunohistochemistry; Membrane Glycoproteins; Membrane Proteins; Neurofibrils; Peptide Fragments; Plaque, Amyloid; Protein Subunits; Serum Amyloid P-Component; Thiazoles | 2007 |
Formation of toxic fibrils of Alzheimer's amyloid beta-protein-(1-40) by monosialoganglioside GM1, a neuronal membrane component.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Membrane; Chromatography, Gel; Circular Dichroism; G(M1) Ganglioside; Microscopy, Electron, Transmission; Neurons; PC12 Cells; Peptide Fragments; Protein Structure, Secondary; Rats; Thiazoles | 2007 |
Surface structure of amyloid-beta fibrils contributes to cytotoxicity.
Topics: Acetylation; Amyloid beta-Peptides; Animals; Benzothiazoles; Carrier Proteins; Cattle; Cell Survival; Cells, Cultured; Fluorescence; Humans; Kidney; Maltose-Binding Proteins; Microscopy, Electron, Transmission; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tryptophan | 2007 |
Conversion of non-fibrillar beta-sheet oligomers into amyloid fibrils in Alzheimer's disease amyloid peptide aggregation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Kinetics; Microscopy, Electron, Transmission; Peptide Fragments; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.
Topics: Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Models, Chemical; Neurotoxins; PC12 Cells; Peptide Fragments; Protein Folding; Protein Structure, Secondary; Rats; Thiazoles | 2007 |
Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Congo Red; Injections, Intraventricular; Long-Term Potentiation; Male; Microscopy, Electron, Transmission; Peptide Fragments; Protein Structure, Secondary; Rats; Rats, Wistar; Synaptic Transmission; Thiazoles | 2008 |
Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Newborn; Benzothiazoles; Cells, Cultured; Cerebral Cortex; Cytokines; Dose-Response Relationship, Drug; Gene Expression Regulation; Interleukin-1alpha; L-Lactate Dehydrogenase; Magnetic Resonance Imaging; Mice; Microglia; Microscopy, Electron, Transmission; Neuroblastoma; Peptide Fragments; Protein Conformation; Thiazoles | 2009 |
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line; Humans; Microscopy, Electron, Transmission; Models, Biological; Neurons; Peptide Fragments; Peptides; Polymers; Protein Binding; Rats; Thiazoles; Time Factors | 2008 |
Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies; Benzothiazoles; Cerebral Cortex; Cholesterol; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hippocampus; Microscopy, Electron, Transmission; Neurofibrillary Tangles; Peptide Fragments; Rats; Rats, Wistar; Thiazoles | 2008 |
Modulation of aggregate size- and shape-distributions of the amyloid-beta peptide by a designed beta-sheet breaker.
Topics: Amyloid beta-Peptides; Benzothiazoles; Calcium Carbonate; Centrifugation, Density Gradient; Citrates; Dimethyl Sulfoxide; Drug Combinations; Fluorescence; Magnesium Oxide; Microscopy, Electron, Transmission; Molecular Weight; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Signal Processing, Computer-Assisted; Software; Thiazoles; Time Factors | 2010 |
PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Animals; Autoradiography; Brain; Cerebral Angiography; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Primates; Protein Binding; tau Proteins; Thiazoles; Tritium | 2011 |
Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Amyloid Neuropathies, Familial; Aspartic Acid; Benzothiazoles; Glutamic Acid; Humans; Kinetics; Leucine; Lysine; Microscopy, Electron, Transmission; Models, Molecular; Mutation, Missense; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phenylalanine; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2009 |
Neuroprotective effects of statins in an in vitro model of Alzheimer's disease.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Calcium; Caspase 3; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholesterol; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Extracellular Signal-Regulated MAP Kinases; In Situ Nick-End Labeling; Lovastatin; Neurons; Neuroprotective Agents; Oncogene Protein v-akt; Peptide Fragments; Rats; Rats, Wistar; Reactive Oxygen Species; Simvastatin; Tetrazolium Salts; Thiazoles; Time Factors | 2009 |
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Hippocampus; Humans; Memory; Memory Disorders; Mice; Mice, Transgenic; Organ Size; Peptide Fragments; Physical Conditioning, Animal; Protease Nexins; Random Allocation; Receptors, Cell Surface; Recognition, Psychology; Thiazoles; Time Factors | 2009 |
On the stability of the soluble amyloid aggregates.
Topics: Amyloid beta-Peptides; Bacillus; Bacterial Proteins; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Linear Models; Models, Biological; Nanoparticles; Nonlinear Dynamics; Osmolar Concentration; Peptide Fragments; Protein Multimerization; Protein Stability; Spectrometry, Fluorescence; Static Electricity; Thiazoles | 2009 |
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Count; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Glycation End Products, Advanced; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Peptide Fragments; Plant Lectins; Plaque, Amyloid; Receptor for Advanced Glycation End Products; Receptors, Immunologic; tau Proteins; Thiazoles | 2010 |
Inhibition of beta 1-40 amyloid fibrillation with N-acetyl-L-cysteine capped quantum dots.
Topics: Acetylcysteine; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Kinetics; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Peptide Fragments; Quantum Dots; Thiazoles | 2010 |
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aptamers, Nucleotide; Benzothiazoles; Densitometry; Dimerization; DNA, Single-Stranded; Humans; Ligands; Peptide Fragments; Protein Binding; Protein Folding; Protein Structure, Secondary; Thiazoles | 2009 |
Up-regulation of the type 3 ryanodine receptor is neuroprotective in the TgCRND8 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Green Fluorescent Proteins; Humans; Mice; Mice, Transgenic; Mutation; Neurons; Peptide Fragments; Phosphopyruvate Hydratase; Potassium; Presenilin-1; RNA, Messenger; RNA, Small Interfering; Ryanodine Receptor Calcium Release Channel; Tetrazolium Salts; Thiazoles; Up-Regulation | 2010 |
Probing the amyloid-beta(1-40) fibril environment with substituted tryptophan residues.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Benzothiazoles; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; Tryptophan | 2010 |
Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.
Topics: Air; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain Chemistry; Fluorescent Dyes; Humans; In Vitro Techniques; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neurodegenerative Diseases; Peptide Fragments; Protein Binding; Protein Conformation; Protein Multimerization; Solutions; Spectrometry, Fluorescence; Thiazoles; Water | 2010 |
Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as beta-amyloid aggregation inhibitors.
Topics: Amyloid beta-Peptides; Benzothiazoles; Hydrogen Bonding; Indoles; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Peptide Fragments; Spectrometry, Fluorescence; Thiazoles | 2010 |
Analysis of monomeric Abeta (1-40) peptide by capillary electrophoresis.
Topics: Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Capillary; Limit of Detection; Peptide Fragments; Spectrophotometry, Ultraviolet; Thiazoles | 2010 |
Catechol derivatives inhibit the fibril formation of amyloid-beta peptides.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Catechols; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Peptide Fragments; Thiazoles | 2010 |
[The effect of meloxicam on the inflammatory reaction induced by beta amyloid protein in Alzheimer's disease rats].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Glial Fibrillary Acidic Protein; Inflammation; Interleukin-1beta; Male; Meloxicam; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2010 |
Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Peptide Fragments; Peptides; Thiazoles | 2010 |
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzothiazoles; Biophysics; Fluorescent Dyes; Humans; Kinetics; Mice; Microelectrodes; Microscopy, Electron, Transmission; Neurons; Patch-Clamp Techniques; Peptide Fragments; Plaque, Amyloid; Protein Binding; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2010 |
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as β-amyloid aggregation inhibitors.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Drug Evaluation, Preclinical; Indoles; Kinetics; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2011 |
A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)₁₋₄₀ and Aβ₁₋₄₂ from the corresponding depsipeptides.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Depsipeptides; Peptide Fragments; Solutions; Thiazoles | 2011 |
The Japanese mutant Aβ (ΔE22-Aβ(1-39)) forms fibrils instantaneously, with low-thioflavin T fluorescence: seeding of wild-type Aβ(1-40) into atypical fibrils by ΔE22-Aβ(1-39).
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Chromatography, Gel; Circular Dichroism; Congo Red; Dimethyl Sulfoxide; Kinetics; Molecular Sequence Data; Mutant Proteins; Mutation; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2011 |
The effect of tachykinin neuropeptides on amyloid β aggregation.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Fluorescent Dyes; Humans; Peptide Fragments; Protein Structure, Secondary; Tachykinins; Thiazoles | 2011 |
Seed-dependent deposition behavior of Aβ peptides studied with wireless quartz-crystal-microbalance biosensor.
Topics: Amyloid beta-Peptides; Antibodies; Benzothiazoles; Biosensing Techniques; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Peptide Fragments; Protein Binding; Quartz Crystal Microbalance Techniques; Spectrometry, Fluorescence; Thiazoles; Wireless Technology | 2011 |
Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity.
Topics: Age Factors; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Brain; Cholinergic Agents; Enzyme-Linked Immunosorbent Assay; Female; Genotype; Humans; Immunoprecipitation; Male; Middle Aged; Nicotine; Nicotinic Agonists; Peptide Fragments; Postmortem Changes; Protein Binding; Statistics as Topic; Thiazoles; Tritium | 2012 |
Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway.
Topics: Adenine Nucleotides; Amyloid beta-Peptides; Antineoplastic Agents, Phytogenic; Autophagy; Blotting, Western; Caspases; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Electron Transport Complex IV; Enzyme Activation; Humans; Lysosomes; Microscopy, Confocal; Microtubules; Mitochondrial Diseases; Mitochondrial Membranes; NAD; Paclitaxel; Peptide Fragments; Signal Transduction; Tetrazolium Salts; Thiazoles; Tubulin | 2011 |
Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Blood Platelets; Brefeldin A; Caspase 3; Cell Death; Cell Fusion; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Female; Gene Expression Regulation; Heat-Shock Proteins; Humans; Hybrid Cells; In Situ Nick-End Labeling; Male; Middle Aged; Mitochondria; Peptide Fragments; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Tetrazolium Salts; Thapsigargin; Thiazoles | 2012 |
Plasma Aβ and PET PiB binding are inversely related in mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Case-Control Studies; Cognition Disorders; Female; Humans; Linear Models; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Retrospective Studies; Thiazoles | 2011 |
H2S releasing aspirin protects amyloid beta induced cell toxicity in BV-2 microglial cells.
Topics: Amyloid beta-Peptides; Animals; Aspirin; Cell Line, Transformed; Cell Survival; Cyclooxygenase 2; Dose-Response Relationship, Drug; Hydrogen Sulfide; Lactate Dehydrogenases; Membrane Potential, Mitochondrial; Mice; Microglia; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Protective Agents; Tetrazolium Salts; Thiazoles; Transcription Factor CHOP; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Aβ(39-42) modulates Aβ oligomerization but not fibril formation.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Humans; Microscopy, Fluorescence; Molecular Dynamics Simulation; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Multimerization; Rats; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2012 |
Inhibiting effect of α(s1)-casein on Aβ(1-40) fibrillogenesis.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Caseins; Circular Dichroism; Hydrodynamics; Light; Microscopy, Atomic Force; Particle Size; Peptide Fragments; Protein Structure, Quaternary; Scattering, Radiation; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2012 |
Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Antioxidants; Arachidonic Acids; Benzothiazoles; Cannabinoids; Cell Line, Tumor; Cell Survival; Chromans; Drug Interactions; Gene Expression Regulation; Humans; Hydrogen Peroxide; Indoles; Lipid Peroxidation; Microscopy, Electron, Transmission; Neuroblastoma; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Thiazoles | 2012 |
Hexafluoroisopropanol induces self-assembly of β-amyloid peptides into highly ordered nanostructures.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Nanostructures; Particle Size; Peptide Fragments; Propanols; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2012 |
Separation and detection of individual Aβ aggregates by capillary electrophoresis with laser-induced fluorescence detection.
Topics: Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Capillary; Lasers; Microscopy, Electron, Scanning Transmission; Peptide Fragments; Spectrophotometry, Ultraviolet; Thiazoles | 2012 |
Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Topics: Administration, Oral; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blood Proteins; Brain; Cell Line; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Design; Humans; In Vitro Techniques; Male; Microsomes, Liver; Models, Molecular; Peptide Fragments; Protein Binding; Protein Conformation; Rats; Rats, Sprague-Dawley; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Swine; Thiazoles | 2012 |
Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Biological Assay; Biophysical Phenomena; Cell Survival; Humans; L-Lactate Dehydrogenase; Microscopy, Electron, Transmission; Models, Molecular; Neurons; PC12 Cells; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Rats; Thiazoles | 2012 |
Overexpression of cellular prion protein (PrP(C)) prevents cognitive dysfunction and apoptotic neuronal cell death induced by amyloid-β (Aβ₁₋₄₀) administration in mice.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Cognition Disorders; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Peptide Fragments; Prion Proteins; Prions; Propidium; Proto-Oncogene Proteins c-bcl-2; Reaction Time; Tetrazolium Salts; Thiazoles | 2012 |
Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils.
Topics: Amyloid beta-Peptides; Benzothiazoles; Glycine max; Humans; Isoflavones; Microscopy, Atomic Force; Microscopy, Electron; Peptide Fragments; Spectrometry, Fluorescence; Thiazoles | 2012 |
Cross-seeding effects of amyloid β-protein and α-synuclein.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Animals; Benzothiazoles; Chromatography, Gel; Humans; Microscopy, Electron, Scanning; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles | 2012 |
Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Drug Delivery Systems; Fluorescent Dyes; Fluorometry; Humans; Microscopy, Electron; Nanoparticles; Negative Staining; Nephelometry and Turbidimetry; Peptide Fragments; Polystyrenes; Recombinant Proteins; Surface Properties; Thiazoles | 2010 |
[Synthesis of benzothiazole derivatives and their binding characteristics with beta-amyloid].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Humans; Peptide Fragments; Protein Binding; Schiff Bases; Surface Plasmon Resonance; Thiazoles | 2012 |
Surface plasmon resonance imaging of amyloid-β aggregation kinetics in the presence of epigallocatechin gallate and metals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Catechin; Copper; Ferric Compounds; Humans; Ions; Kinetics; Metals; Microscopy, Electron, Transmission; Peptide Fragments; Surface Plasmon Resonance; Thiazoles; Zinc | 2013 |
Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Coordination Complexes; Drug Design; Humans; Organotechnetium Compounds; Peptide Fragments; Protein Binding; Radiography; Rhenium; Structure-Activity Relationship; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2013 |
Peptide concentration alters intermediate species in amyloid β fibrillation kinetics.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Humans; Kinetics; Microscopy, Electron, Transmission; Peptide Fragments; Peptides; Protein Conformation; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2013 |
Association of plasma and cortical amyloid beta is modulated by APOE ε4 status.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Brain; Cerebral Cortex; Cognitive Dysfunction; Female; Humans; Male; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
Tranilast binds to aβ monomers and promotes aβ fibrillation.
Topics: Amyloid; Amyloid beta-Peptides; Anti-Allergic Agents; Antineoplastic Agents; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Molecular Docking Simulation; Nuclear Magnetic Resonance, Biomolecular; ortho-Aminobenzoates; Peptide Fragments; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Thiazoles | 2013 |
Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloidosis; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Diabetes Mellitus, Type 2; Islet Amyloid Polypeptide; Kinetics; Microscopy, Electron, Transmission; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Binding; Protein Folding; Protein Multimerization; Rats; Spectrometry, Fluorescence; Thiazoles | 2014 |
Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Benzothiazoles; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptide Fragments; Postmortem Changes; Radionuclide Imaging; Thiazoles; Tissue Distribution; Tritium | 2013 |
Modulation of Aβ(1-40) peptide fibrillar architectures by Aβ-based peptide amphiphiles.
Topics: Amyloid beta-Peptides; Benzothiazoles; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Thiazoles | 2013 |
Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes.
Topics: Adsorption; Air; Amyloid beta-Peptides; Animals; Benzothiazoles; Caenorhabditis elegans; Cell Extracts; Chromatography, High Pressure Liquid; Kinetics; Mice; Microscopy, Electron; Peptide Fragments; Plastics; Protein Denaturation; Quartz; Thiazoles; Time Factors; Water | 2013 |
Inhibiting and reversing amyloid-β peptide (1-40) fibril formation with gramicidin S and engineered analogues.
Topics: Amyloid beta-Peptides; Benzothiazoles; Gramicidin; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship; Thiazoles | 2013 |
Gd(3+) complexes conjugated to Pittsburgh compound B: potential MRI markers of β-amyloid plaques.
Topics: Amyloid beta-Peptides; Aniline Compounds; Blood-Brain Barrier; Gadolinium; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Magnetic Resonance Imaging; Micelles; Organometallic Compounds; Peptide Fragments; Permeability; Plaque, Amyloid; Serum Albumin; Thiazoles; Water | 2014 |
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Benzene Derivatives; Cell Line, Tumor; Enzyme Assays; Humans; Imidazoles; Mutation; Peptide Fragments; Presenilin-1; Proteolysis; Receptor, Notch1; Solubility; Structure-Activity Relationship; Thiazoles | 2014 |
Rationally designed peptoids modulate aggregation of amyloid-beta 40.
Topics: Amyloid beta-Peptides; Benzothiazoles; Binding, Competitive; Circular Dichroism; Fluorescence; Immunoblotting; Peptide Fragments; Peptoids; Protein Structure, Secondary; Thiazoles; Time Factors | 2014 |
Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Chi-Square Distribution; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Psychiatric Status Rating Scales; Radionuclide Imaging; Regression Analysis; tau Proteins; Thiazoles | 2014 |
Different effect of vitamin D2 and vitamin D3 on amyloid-β40 aggregation in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cholecalciferol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ergocalciferols; Humans; In Vitro Techniques; Microscopy, Electron; Models, Chemical; Molecular Docking Simulation; Peptide Fragments; Plaque, Amyloid; Protein Interaction Mapping; Quartz Crystal Microbalance Techniques; Thiazoles; Time Factors | 2014 |
The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Cell Culture Techniques; Cell Line; Cricetinae; Disease Models, Animal; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Neurons; Peptide Fragments; Solubility; Thermodynamics; Thiazoles | 2014 |
Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Crown Ethers; Hippocampus; Ligands; Mice; Microscopy, Confocal; Peptide Fragments; Thiazoles | 2014 |
Ultrafast propagation of β-amyloid fibrils in oligomeric cloud.
Topics: Amyloid beta-Peptides; Benzothiazoles; Flocculation; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Peptide Fragments; Protein Aggregates; Protein Multimerization; Protein Structure, Secondary; Quartz Crystal Microbalance Techniques; Solutions; Thiazoles | 2014 |
Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by Aβ(1-40) and Aβ(1-42).
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Spectrometry, Fluorescence; Thiazoles | 2015 |
Interaction of PiB-derivative metal complexes with beta-amyloid peptides: selective recognition of the aggregated forms.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Coordination Complexes; Heterocyclic Compounds, 1-Ring; Humans; Lanthanoid Series Elements; Magnetic Resonance Spectroscopy; Peptide Fragments; Protein Aggregates; Surface Plasmon Resonance; Thiazoles | 2015 |
Thioflavin T templates amyloid β(1-40) conformation and aggregation pathway.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Fluorescence Recovery After Photobleaching; Fluorescent Dyes; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Protein Conformation; Protein Multimerization; Protein Stability; Protein Structure, Secondary; Thiazoles | 2015 |
Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age.
Topics: Adipokines; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Asymptomatic Diseases; Biomarkers; Chitinase-3-Like Protein 1; Cohort Studies; Female; Genotyping Techniques; Humans; Lectins; Male; Middle Aged; Neurocalcin; Peptide Fragments; Positron-Emission Tomography; tau Proteins; Thiazoles | 2015 |
Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anthocyanins; Benzothiazoles; Brain; Cell Line, Tumor; Cognition; Cognition Disorders; Female; Humans; Male; Mice; Microscopy, Atomic Force; Peptide Fragments; Plant Extracts; Polyphenols; Thiazoles; Vaccinium myrtillus | 2016 |
Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Brain; Disease Models, Animal; Female; Male; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2015 |
Heterogeneity and Turnover of Intermediates during Amyloid-β (Aβ) Peptide Aggregation Studied by Fluorescence Correlation Spectroscopy.
Topics: Amyloid beta-Peptides; Benzothiazoles; Humans; Peptide Fragments; Protein Aggregates; Spectrometry, Fluorescence; Thiazoles | 2015 |
Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils.
Topics: Aged; Alkenes; Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Aniline Compounds; Benzoates; Benzothiazoles; Binding Sites; Brain; Chalcones; Female; Fluorescent Dyes; Humans; Ligands; Peptide Fragments; Positron-Emission Tomography; Thiazoles; Tritium | 2016 |
Methionine oxidation reduces lag-times for amyloid-β(1-40) fiber formation but generates highly fragmented fibers.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Humans; Hydrogen Peroxide; Kinetics; Methionine; Microscopy, Electron, Transmission; Oxidation-Reduction; Peptide Fragments; Solutions; Spectrometry, Fluorescence; Thiazoles | 2016 |
Intranasal Administration of a Polyethylenimine-Conjugated Scavenger Peptide Reduces Amyloid-β Accumulation in a Mouse Model of Alzheimer's Disease.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Benzothiazoles; Cell Line, Tumor; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Mutation; Neuroblastoma; Peptide Fragments; Polyethyleneimine; Positron-Emission Tomography; Presenilin-1; Thiazoles | 2016 |
A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Humans; Inclusion Bodies; Methionine; Peptide Fragments; Recombinant Proteins; Spectrophotometry, Ultraviolet; Staining and Labeling; Thiazoles | 2016 |
Citrullination and deamidation affect aggregation properties of amyloid β-proteins.
Topics: Amides; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Citrulline; Humans; Hydrogen-Ion Concentration; Molecular Dynamics Simulation; Peptide Fragments; Protein Aggregates; Protein Conformation, beta-Strand; Protein Processing, Post-Translational; Solubility; Static Electricity; Thiazoles | 2016 |
Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Female; Humans; Logistic Models; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Thiazoles | 2017 |
Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; Male; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Thiazoles | 2017 |
Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Models, Molecular; Peptide Fragments; Protein Binding; Protein Conformation, beta-Strand; Thermodynamics; Thiazoles | 2017 |
Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Click Chemistry; Humans; Magnets; Microspheres; Peptide Fragments; Protein Aggregates; Thiazoles | 2017 |
E22G Pathogenic Mutation of β-Amyloid (Aβ) Enhances Misfolding of Aβ40 by Unexpected Prion-like Cross Talk between Aβ42 and Aβ40.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Mutation; Peptide Fragments; Prions; Protein Folding; Thiazoles | 2018 |
Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging.
Topics: Aged; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cohort Studies; Female; Humans; Immunoassay; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2018 |
Aggregation kinetics of the Aβ1-40 peptide monitored by NMR.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Particle Size; Peptide Fragments; Protein Multimerization; Thiazoles | 2018 |
Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Biomarkers; Case-Control Studies; Cognitive Dysfunction; Cross-Sectional Studies; Early Diagnosis; Female; Fluorodeoxyglucose F18; Genotype; Humans; Male; Neuroimaging; Peptide Fragments; Phosphorylation; Plaque, Amyloid; Positron-Emission Tomography; Prodromal Symptoms; tau Proteins; Thiazoles | 2019 |
Hyper-homocysteinemia alters amyloid peptide-clusterin interactions and neuroglial network morphology and function in the caudate after intrastriatal injection of amyloid peptides.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Benzothiazoles; Caudate Nucleus; Clusterin; Drug Interactions; Food, Formulated; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Models, Biological; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazoles | 2007 |
Biological characters of [18F]O-FEt-PIB in a rat model of Alzheimer's disease using micro-PET imaging.
Topics: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Diagnostic Imaging; Disease Models, Animal; Fluorodeoxyglucose F18; Hippocampus; Male; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thalamus; Thiazoles; Tissue Distribution | 2008 |
Resolution of localized small molecule-Aβ interactions by deep-ultraviolet resonance Raman spectroscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Flavonoids; Humans; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Spectrum Analysis, Raman; Thiazoles | 2011 |