Compounds > thiazoles
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thiazoles and alpha-synuclein

thiazoles has been researched along with alpha-synuclein in 121 studies

Research

Studies (121)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (1.65)18.2507
2000's51 (42.15)29.6817
2010's65 (53.72)24.3611
2020's3 (2.48)2.80

Authors

AuthorsStudies
Curran, MD; El-Agnaf, OM; Jakes, R; Wallace, A1
Bianchi, E; Curran, MD; El-Agnaf, OM; Ingenito, R; Jakes, R; Middleton, D; Neill, D; Pessi, A; Wallace, A1
Conway, KA; Ding, TT; Lansbury, PT; Lee, SJ; Rochet, JC; Williamson, RE1
Conway, KA; Harper, JD; Lansbury, PT1
Bodles, AM; Campbell, P; Guthrie, DJ; Harriott, P; Irvine, GB1
Farer, M; Hardy, J; Lee, JM; Ostrerova-Golts, N; Petrucelli, L; Wolozin, B1
Easson, C; Farrer, M; Hardy, J; Hussey, J; Ko, L; Mehta, ND; Yen, S; Yen, SH1
Kakimura, J; Kitamura, Y; Kohno, Y; Nomura, Y; Takata, K; Taniguchi, T1
Chung, KC; Kim, J; Kim, YS; Lee, D; Lee, EK; Paik, SR; Sung, JY1
Iwata, A; Kanazawa, I; Maruyama, M; Nukina, N1
Duda, JE; Giasson, BI; Golbe, LI; Lee, VM; Mabon, ME; Miller, DC; Trojanowski, JQ1
Antony, T; Cherny, D; Heim, G; Hoyer, W; Jovin, TM; Subramaniam, V1
Choi, SY; Kang, JH; Kang, TC; Kim, KS; Kwon, HY; Won, MH1
Fink, AL; Munishkina, LA; Phelan, C; Uversky, VN1
Du, HN; Hu, HY; Hu, J; Li, HT; Luo, XY; Tang, L; Zhou, JW1
Emadi, S; Liu, R; Lyubchenko, Y; McAllister, C; Messer, A; Schulz, P; Sierks, MR; Yuan, B1
Fink, AL; Han, S; Kaylor, J; Rajamani, S; Zhou, F; Zhu, M1
Fernández, CO; Griesinger, C; Hoyer, W; Jares-Erijman, EA; Jovin, TM; Subramaniam, V; Zweckstetter, M1
Dauer, WT; Dietrich, P; Rideout, HJ; Stefanis, L; Wang, Q1
Christodoulou, J; Dedmon, MM; Dobson, CM; Wilson, MR1
Fukuhara, Y; Ishitani, R; Katsube, N; Kuwae, T; Mizuno, Y; Mochizuki, H; Nakano, T; Nakashima, K; Ohama, E; Sunaga, K; Tajima, H; Takeshima, T; Tanaka, M; Tsuchiya, K1
Chung, KC; Kim, J; Lee, CH; Lee, HJ; Lee, ST; Oh, YJ; Paik, SR; Park, SM; Sung, JY; Um, JW1
Ali, FE; Barnham, KJ; Bottomley, SP; Cappai, R; Cherny, RA; Culvenor, JG; Curtain, CC; Galatis, D; Hill, AF; Leck, SL; Masters, CL; Sharples, RA; Smith, DP; Tew, DJ; Williamson, NA1
Minichiello, L; Unsicker, K; von Bohlen und Halbach, O1
Hongo, K; Kawata, Y; Kusaka, E; Mizobata, T; Yagi, H1
Bodner, N; Edridge, S; Fink, AL; Hong, DP; Kaylor, J; Yamin, G1
Champy, P; Duyckaerts, C; Féger, J; Hirsch, EC; Höglinger, GU; Khondiker, ME; Lannuzel, A; Lombes, A; Medja, F; Michel, PP; Oertel, WH; Prigent, A; Ruberg, M1
Alfonso, A; Burnam, L; Hoener, M; Liu, L; Perier, C; Przedborski, S; Rodrigues, CM; Saha, S; Sluder, A; Steer, C; Ved, R; Westlund, B; Wolozin, B1
Lev, N; Melamed, E; Offen, D1
Duka, T; Sidhu, A1
Naiki, H; Noguchi-Shinohara, M; Ono, K; Yamada, M; Yoshita, M1
Ono, K; Yamada, M1
Hirohata, M; Ono, K; Yamada, M1
Ahn, JS; Kim, JH; Lee, JH; Paik, SR1
Austin, CP; Honson, NS; Huang, W; Inglese, J; Johnson, RL; Kuret, J1
Adlard, PA; Barnham, KJ; Cappai, R; Cortés, M; Culvenor, JG; Fodero-Tavoletti, MT; Foster, LE; Laughton, KM; Leone, L; Li, QX; Masters, CL; McLean, CA; Perez, K; Rowe, CC; Smith, DP; Villemagne, VL1
Crowther, RA; Fraser, G; Goedert, M; Jakes, R; Serpell, LC; Zibaee, S1
Cappai, R; Carver, JA; Jankova, L; Rekas, A; Thorn, DC1
Beach, TG; Fraser, G; Goedert, M; Libri, V; Lockhart, A; Osredkar, T; Spillantini, MG; Sue, L; Velasco, A; Ye, L1
Danzer, KM; Duan, W; Finger, S; Garidel, P; Giese, A; Glabe, CG; Habeck, M; Heinzelmann, U; Högen, T; Kostka, M; Kretzschmar, H; Levin, J; Ross, CA; Wagner, R; Wirth, A1
Datki, ZL; Földi, I; Hunya, A; Penke, B; Soós, K; Szabó, A; Szegedi, V; Zádori, D; Zarándi, M1
Chae, SW; Choi, HJ; Hwang, O; Kang, BY1
Battistin, L; Bellucci, A; Collo, G; Missale, C; Sarnico, I; Spano, P1
Rao, KS1
Ko, HH; Ko, LW; Kulathingal, JG; Lin, WL; Yen, SH1
Choe, YJ; Gai, WP; Hahn, JS; Kang, S; Kim, HY; Lee, IH; Lee, JH; Paik, SR1
Fink, AL; Hong, DP; Uversky, VN1
Feist, G; Ghribi, O; Rantham Prabhakara, JP; Schommer, E; Thomasson, S; Thompson, A1
Kerk, SY; Lim, TM; Xiong, GG; Zhou, ZD1
Chiappe, D; Grimminger, V; Hang, I; Lashuel, HA; Moniatte, M; Pignat, V; Schmid, AW1
Hirohata, M; Ikeda, T; Morinaga, A; Ono, K; Yamada, M1
Cappai, R; Fodero-Tavoletti, MT; Furumoto, S; Kudo, Y; Masters, CL; Mulligan, RS; Okamura, N; Rowe, CC; Villemagne, VL; Yanai, K1
Cheng, H; Wang, CC; Wang, L1
Burack, MA; Cairns, NJ; Flores, HP; Hartlein, J; Perlmutter, JS; Taylor-Reinwald, L1
Ahmad, A1
Giasson, BI; Waxman, EA1
Giehm, L; Otzen, DE1
Carver, JA; Christodoulou, J; Devlin, GL; Dobson, CM; Ecroyd, H; Knowles, TP; Meehan, S; Skepper, JN; Waudby, CA; Welland, ME1
Björklund, A; Brundin, P; Englund, E; Li, JY; Lindvall, O; Rehncrona, S; Widner, H1
Haddix, T; Lee, VM; Nakashima-Yasuda, H; Robinson, J; Trojanowski, JQ; Uryu, K1
Arai, H; Baba, T; Fukuda, H; Funaki, Y; Furumoto, S; Hasegawa, T; Itoyama, Y; Iwata, R; Kikuchi, A; Kobayashi, M; Kudo, Y; Miki, Y; Mori, F; Okamura, N; Sugeno, N; Takahashi, S; Takeda, A; Tashiro, M; Wakabayashi, K; Yanai, K1
Jiang, H; Li, WJ; Song, N; Xie, JX1
Goto, Y; Hongo, K; Ito, N; Kawata, Y; Mizobata, T; Ogawa, S; Sakane, I; Takeuchi, H; Yagi, H1
Abedini, A; Meng, F; Plesner, A; Raleigh, DP; Verchere, CB1
Bae, SY; Hwang, H; Kim, HK; Kim, JH; Kim, S; Kim, TD; Lee, S; Yoon, HC1
Fink, AL; Han, S; Hong, DP; Uversky, VN1
Burack, MA; Cairns, NJ; Campbell, MC; Flores, HP; Foster, ER; Hartlein, J; Hershey, T; Perlmutter, JS1
Chang, JY; Hong, DP; Jiang, C; Xiong, W1
Danzer, KM; Giese, A; Hengerer, B; Herms, J; Högen, T; Hüls, S; Vassallo, N1
Jethva, PN; Makwana, PK; Roy, I1
C Serpell, L; Cherny, I; Crockett, R; Gazit, E; Kearn, G; P Jarvis, S; S Mostaert, A1
Feng, LR; Maguire-Zeiss, KA1
Andersen, NH; Bisaglia, M; Bubacco, L; Huggins, KN; Kapurniotu, A; Tatarek-Nossol, M1
Ikeda, T; Mochizuki, H; Nihira, T; Ono, K; Takasaki, J; Teplow, DB; Yamada, M1
Li, J; Li, S; Liu, D; Yang, J; Zhang, B; Zhang, R; Zhang, X; Zhao, P1
Bannach, O; Birkmann, E; Funke, SA; Hübinger, S; Willbold, D1
Chen, Y; Ding, ZT; Jiang, YP; Lan, DM; Liu, FT; Ren, HM; Wang, J; Wu, JJ; Yue, ZY; Zhao, J1
Dikiy, I; Eliezer, D; Fares, MB; Fauvet, B; Lashuel, HA; Samuel, F; Tandon, A1
Ikeda, T; Ono, K; Takahashi, R; Yamada, M1
Coffey, MP; Dang, L; Klaver, AC; Loeffler, DA; Smith, LM1
Abedini, A; Bhattacharya, M; Cao, P; Ladiwala, AR; Langen, R; Perchiacca, JM; Raleigh, DP; Schmidt, AM; Tessier, PM; Varkey, J1
Brucale, M; Bubacco, L; Codolo, G; de Bernard, M; Plotegher, N; Pozzobon, T; Tessari, I1
Egoz-Matia, N; Frenkel-Pinter, M; Gazit, E; Levy-Sakin, M; Masliah, E; Patrick, C; Rockenstein, E; Schiller, A; Segal, D; Shaltiel-Karyo, R1
Christiansen, G; Giehm, L; Kyrsting, A; Langkilde, AE; Macchi, F; Manno, M; Nielsen, NC; Nielsen, SB; Oddershede, L; Otzen, DE; Raccosta, S; Svane, AS; Vestergaard, B1
Casadei, N; De Heer, R; Kahle, PJ; Klucken, J; Krüger, R; Lucas, JJ; Noldus, LP; Nuber, S; Pöhler, AM; Riess, O; Schwedhelm, I; Spruijt, B; Tomás-Zapico, C; Torres-Peraza, J; Witz, A; Zamolo, I1
Cheng, D; Hu, JY; Li, Z; Liu, J; Liu, YY; Liu, ZL; Wang, HJ; Wang, LM; Wang, Y; Wen, XJ; Yang, XY1
Berrocal, R; Indi, SS; Rao, KS; Sambasiva Rao, KR; Vasudevaraju, P1
Bongarzone, ER; Cantuti-Castelvetri, L; Celej, MS; Claycomb, KI; Crocker, SJ; Gallea, JI; Givogri, MI; Li, G; Lopez-Rosas, A; Marshall, MS; Santos, MB; Smith, BR; van Breemen, R1
Anoop, A; Chakraborty, C; Das, S; Dutta, P; Ghosh, D; Jacob, RS; Jha, NN; Maji, SK; Malik, S; Mankar, S; Mondal, M; Singh, PK1
Calabrese, AN; Carver, JA; Liu, Y; Pukala, TL1
Coelho-Cerqueira, E; Follmer, C; Pinheiro, AS1
Bose, A; Chowdhury, PK; Gautam, S; Karmakar, S1
Claessens, MM; Iyer, A; Petersen, NO; Subramaniam, V1
Bartels, T; Kristal, BS; Luth, ES; Selkoe, DJ; Stavrovskaya, IG1
Basak, S; Chattopadhyay, K; Prasad, GV; Varkey, J1
Baron, T; Billard, T; Bouillot, C; Chauveau, F; Lancelot, S; Levigoureux, E; Verchere, J; Verdurand, M; Zimmer, L1
Breydo, L; Morgan, D; Uversky, VN1
Buddhala, C; Campbell, MC; Koller, JM; Kotzbauer, PT; Perlmutter, JS; Snyder, AZ1
Rochet, JC; Stanciu, LA; Zhang, H1
Chorell, E; Edlund, H; Sharma, SK; Steneberg, P; Vernersson-Lindahl, E; Wittung-Stafshede, P1
Cremades, N; Dalla Serra, M; Dear, AJ; Dobson, CM; Horrocks, MH; Klenerman, D; Knowles, TP; Tosatto, L1
Baekelandt, V; Debyser, Z; Deleersnijder, A; Gerard, M; Macchi, F; Michiels, A; Munck, S; Pottel, H; Van den Haute, C1
Åden, J; Almqvist, F; Chorell, E; Kindahl, T; Krishnan, KS; Singh, P; Wittung-Stafshede, P1
Segers-Nolten, I; Sidhu, A; Subramaniam, V1
Decossas-Mendoza, M; Krisa, S; Lambert, O; Mérillon, JM; Richard, T; Temsamani, H1
Breydo, L; Jäger, AK; Jorgensen, L; Lobbens, ES; Skamris, T; Uversky, V; van de Weert, M; Vestergaard, B1
Bickle, L; Hopwood, JJ; Karageorgos, L1
Hasegawa, M; Higuchi, M; Hisanaga, SI; Imura, S; Masuda-Suzukake, M; Ono, M; Shimozawa, A; Takahara, D; Tarutani, A; Yanai, K1
Claessens, MM; Raussens, V; Segers-Nolten, I; Sidhu, A; Subramaniam, V1
Aigbirhio, FI; Buell, AK; Fisher, E; Janik, M; Richardson, R; Tóth, G; Zhao, Y1
Chen, Y; Jiang, F; Lei, H; Li, JD; Ma, YT; Tan, J; Zhang, J; Zhang, Y1
Benavides, GA; Chatham, JC; Cofield, SS; Darley-Usmar, V; Ouyang, X; Redmann, M; Shacka, JJ; Wani, WY; Zhang, J1
Kumar, H; Kumari, P; Singh, J; Udgaonkar, JB1
Davis, TP; Ding, F; Kakinen, A; Ke, PC; Nowell, CJ; Pilkington, EH; Sun, Y; Wang, B; Wang, M; Xing, Y1
Billard, T; Chauveau, F; Lancelot, S; Levigoureux, E; Perret-Liaudet, A; Quadrio, I; Verdurand, M; Zeinyeh, W; Zimmer, L1
Abeyawardhane, DL; Crozier, MK; Fernández, RD; Forney, AK; Heitger, DR; Lucas, HR; Murgas, CJ1
Gardberg, M; Rinne, JO; Röyttä, M; Scheinin, NM1
Bateman, RJ; Benzinger, TLS; Berge, G; Bråthen, G; Bu, G; Fagan, A; Grøntvedt, GR; Karch, CM; Lauridsen, C; Morris, JC; Møller, I; Nielsen, HM; Nordberg, A; Patra, K; Rodriguez-Vieitez, E; Sando, SB; Twohig, D; White, LR1
Tavassoly, O; Vocadlo, DJ; Yue, J1
Jayaprakash Rao, M; Manjithaya, R; Suresh, SN1
Abadi, AH; Abdel-Halim, M; AlNajjar, YT; Becker, W; ElHady, AK; Engel, M; Gabr, M; Salah, M; Wilms, G1

Other Studies

121 other study(ies) available for thiazoles and alpha-synuclein

ArticleYear
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.
    FEBS letters, 1998, Nov-27, Volume: 440, Issue:1-2

    Topics: alpha-Synuclein; Amino Acid Substitution; Amyloid; Benzothiazoles; Biopolymers; Circular Dichroism; Dimerization; Humans; Hydrogen-Ion Concentration; Lewy Bodies; Microscopy, Electron; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Structure, Secondary; Recombinant Proteins; Synucleins; Thiazoles

1998
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.
    FEBS letters, 1998, Nov-27, Volume: 440, Issue:1-2

    Topics: alpha-Synuclein; Amyloid; Apoptosis; Benzothiazoles; Biopolymers; Cell Nucleus; Cell Survival; Circular Dichroism; Humans; Microscopy, Electron; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurodegenerative Diseases; Neurons; Parkinson Disease; Peptides; Protein Structure, Secondary; Synucleins; Thiazoles; Tumor Cells, Cultured

1998
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Jan-18, Volume: 97, Issue:2

    Topics: Age of Onset; alpha-Synuclein; Amino Acid Substitution; Amyloid; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Fluorescence; Humans; Microscopy, Atomic Force; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Conformation; Synucleins; Thiazoles; Ultracentrifugation

2000
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
    Biochemistry, 2000, Mar-14, Volume: 39, Issue:10

    Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine

2000
Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils.
    European journal of biochemistry, 2000, Volume: 267, Issue:8

    Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Cell Survival; Circular Dichroism; Humans; Microscopy, Electron; Molecular Sequence Data; Nerve Tissue Proteins; Oxidation-Reduction; PC12 Cells; Peptide Fragments; Protein Structure, Secondary; Rats; Solubility; Synucleins; Tetrazolium Salts; Thiazoles; Time Factors

2000
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-15, Volume: 20, Issue:16

    Topics: alpha-Synuclein; Benzothiazoles; Cell Survival; Free Radicals; Humans; Inclusion Bodies; Iron; Lewy Bodies; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oxidative Stress; Parkinson Disease; Synucleins; Thiazoles; Tumor Cells, Cultured; Ubiquitins

2000
Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.
    Journal of neurochemistry, 2000, Volume: 75, Issue:6

    Topics: alpha-Synuclein; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Immunoblotting; Kidney; Mutation; Nerve Tissue Proteins; Neurons; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; RNA, Messenger; Sulfhydryl Compounds; Synucleins; Tetrazolium Salts; Thiazoles; Transfection; Vitamin K

2000
Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole.
    European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2

    Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Antiparkinson Agents; Azepines; Benzothiazoles; Caspases; Cell-Free System; Cytochrome c Group; Cytosol; Deoxyadenine Nucleotides; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Nerve Tissue Proteins; Organelles; Pramipexole; Synucleins; Thiazoles; Tumor Cells, Cultured

2001
Multiple ligand interaction of alpha-synuclein produced various forms of protein aggregates in the presence of Abeta25-35, copper, and eosin.
    Brain research, 2001, Jul-20, Volume: 908, Issue:1

    Topics: alpha-Synuclein; Amyloid beta-Peptides; Benzothiazoles; Cells, Cultured; Copper; Eosine Yellowish-(YS); Fluorescent Dyes; Ligands; Microscopy, Electron; Nerve Tissue Proteins; Neurodegenerative Diseases; Peptide Fragments; Polymers; Protein Structure, Tertiary; Synucleins; Thiazoles

2001
alpha-Synuclein affects the MAPK pathway and accelerates cell death.
    The Journal of biological chemistry, 2001, Nov-30, Volume: 276, Issue:48

    Topics: 14-3-3 Proteins; alpha-Synuclein; Amino Acid Sequence; Apoptosis; Blotting, Northern; Butadienes; Cell Death; Cell Line; Cell Survival; Coloring Agents; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Library; Glutathione Transferase; Humans; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; MAP Kinase Signaling System; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Nitriles; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Synucleins; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Tyrosine 3-Monooxygenase

2001
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
    Acta neuropathologica, 2002, Volume: 104, Issue:1

    Topics: Adult; alpha-Synuclein; Archives; Benzothiazoles; Brain; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Male; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Parkinson Disease; Synucleins; tau Proteins; Thiazoles

2002
Dependence of alpha-synuclein aggregate morphology on solution conditions.
    Journal of molecular biology, 2002, Sep-13, Volume: 322, Issue:2

    Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Ions; Kinetics; Magnesium; Microscopy, Atomic Force; Microscopy, Electron; Nerve Tissue Proteins; Osmolar Concentration; Protein Binding; Protein Structure, Quaternary; Sodium; Solutions; Synucleins; Thiazoles

2002
The ceruloplasmin and hydrogen peroxide system induces alpha-synuclein aggregation in vitro.
    Biochimie, 2002, Volume: 84, Issue:7

    Topics: alpha-Synuclein; Benzothiazoles; Ceruloplasmin; Humans; Hydrogen Peroxide; Hydroxyl Radical; Immunoblotting; Microscopy, Electron; Nerve Tissue Proteins; Protein Folding; Spectrometry, Fluorescence; Staining and Labeling; Synucleins; Thiazoles

2002
Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes.
    Biochemistry, 2003, Mar-11, Volume: 42, Issue:9

    Topics: Alcohols; alpha-Synuclein; Benzothiazoles; Circular Dichroism; Ethanol; Fluorescent Dyes; Humans; Kinetics; Light; Models, Chemical; Nerve Tissue Proteins; Phospholipids; Propanols; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Scattering, Radiation; Solvents; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Trifluoroethanol

2003
A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.
    Biochemistry, 2003, Jul-29, Volume: 42, Issue:29

    Topics: Alanine; alpha-Synuclein; Amino Acid Motifs; Benzothiazoles; Circular Dichroism; Escherichia coli; Glycine; Humans; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Peptides; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Synucleins; Thiazoles; Time Factors; Valine

2003
Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments.
    Biochemistry, 2004, Mar-16, Volume: 43, Issue:10

    Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Binding Sites, Antibody; Epitope Mapping; Fluorescent Dyes; Humans; Immunoglobulin Variable Region; Inovirus; Kinetics; Microscopy, Atomic Force; Molecular Sequence Data; Nerve Tissue Proteins; Peptide Library; Protein Structure, Tertiary; Recombinant Proteins; Solubility; Synucleins; Thiazoles

2004
The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils.
    The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26

    Topics: alpha-Synuclein; Anaerobiosis; Benzothiazoles; Circular Dichroism; Escherichia coli; Flavanones; Flavonoids; Humans; Light; Lysine; Microscopy, Atomic Force; Molecular Weight; Nerve Tissue Proteins; Oxidation-Reduction; Protein Conformation; Quinones; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Synucleins; Thiazoles; Tyrosine

2004
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.
    The EMBO journal, 2004, May-19, Volume: 23, Issue:10

    Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Molecular Sequence Data; Molecular Structure; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Polyamines; Protein Structure, Secondary; Synucleins; Thiazoles

2004
alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.
    The Journal of biological chemistry, 2004, Nov-05, Volume: 279, Issue:45

    Topics: Acetylcysteine; alpha-Synuclein; Animals; Apoptosis; Benzothiazoles; Blotting, Western; Cells, Cultured; Cytoplasm; Genotype; Lewy Bodies; Mice; Mice, Knockout; Microscopy, Fluorescence; Nerve Tissue Proteins; Neurons; Protease Inhibitors; Proteasome Inhibitors; Rats; Synucleins; Thiazoles; Time Factors; Ubiquitin

2004
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species.
    The Journal of biological chemistry, 2005, Apr-15, Volume: 280, Issue:15

    Topics: alpha-Synuclein; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Flow Cytometry; Genetic Vectors; HSP70 Heat-Shock Proteins; Humans; Lewy Bodies; Magnetic Resonance Spectroscopy; Microscopy, Electron; Microscopy, Fluorescence; Molecular Chaperones; Nerve Tissue Proteins; Protein Binding; Protein Folding; Protein Structure, Secondary; Subcellular Fractions; Synucleins; Thiazoles; Time Factors

2005
Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.
    The European journal of neuroscience, 2005, Volume: 21, Issue:2

    Topics: Acetates; Aged; Aged, 80 and over; alpha-Synuclein; Animals; beta-Synuclein; Blotting, Western; Brain; Cell Aggregation; Cell Count; Chlorocebus aethiops; COS Cells; Female; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Green Fluorescent Proteins; Humans; Immunohistochemistry; Immunoprecipitation; Inclusion Bodies; Indoles; Lewy Bodies; Male; Microscopy, Electron, Transmission; Middle Aged; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Parkinson Disease; Polymerase Chain Reaction; Synucleins; Thiazoles; Transfection; Ubiquitin

2005
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.
    The Journal of biological chemistry, 2005, Jul-01, Volume: 280, Issue:26

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Catalytic Domain; Cell Line, Tumor; Cell Survival; Coloring Agents; Culture Media; Dopamine; Humans; Immunohistochemistry; Insecta; Kinetics; Male; Matrix Metalloproteinase 3; Matrix Metalloproteinases; Nerve Tissue Proteins; Nitric Oxide; Nitrites; Oxidopamine; Oxygen; Parkinson Disease; Protein Binding; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substantia Nigra; Synucleins; Tetrazolium Salts; Thiazoles; Time Factors; Transfection

2005
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:10

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Circular Dichroism; Dopamine; Ferric Compounds; Humans; Parkinson Disease; Protein Folding; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Thiazoles

2005
Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:12

    Topics: Aging; Alkaloids; alpha-Synuclein; Animals; Axons; Benzothiazoles; Brain-Derived Neurotrophic Factor; Crosses, Genetic; Densitometry; Dopamine; Fluorescent Dyes; Heterozygote; Immunohistochemistry; Indoles; Ligands; Male; Mice; Mutation; Neurons; Parkinson Disease; Phenotype; Quinolines; Receptor, trkB; Receptor, trkC; Signal Transduction; Substantia Nigra; Thiazoles; Tyrosine 3-Monooxygenase

2005
Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases.
    The Journal of biological chemistry, 2005, Nov-18, Volume: 280, Issue:46

    Topics: alpha-Synuclein; Amyloid; Animals; Benzothiazoles; Biochemistry; Cattle; Chaperonin 10; Chickens; Circular Dichroism; Escherichia coli; Humans; Insulin; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Biological; Molecular Chaperones; Muramidase; Parkinson Disease; Peptides; Protein Binding; Protein Conformation; Scattering, Radiation; Thiazoles; X-Rays

2005
Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein.
    Journal of molecular biology, 2005, Oct-21, Volume: 353, Issue:2

    Topics: alpha-Synuclein; Anilino Naphthalenesulfonates; Benzothiazoles; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Parkinson Disease; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Tryptophan; Tyrosine

2005
The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.
    Journal of neurochemistry, 2005, Volume: 95, Issue:4

    Topics: alpha-Synuclein; Amyloid beta-Peptides; Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Behavior, Animal; Benzothiazoles; Body Weight; Caspase 3; Caspases; Cell Death; Cerebral Cortex; Cytarabine; Diagnostic Imaging; Dopamine and cAMP-Regulated Phosphoprotein 32; Doxorubicin; Dystonia; Electron Transport Complex III; Enzyme Activation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Locomotion; Male; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphopyruvate Hydratase; Phosphorylation; Posture; Psychomotor Performance; Rats; Rats, Inbred Lew; Rotenone; tau Proteins; Tauopathies; Thiazoles; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase; Ubiquitin; Uncoupling Agents

2005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases

2005
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.
    Neuroscience letters, 2006, May-15, Volume: 399, Issue:1-2

    Topics: alpha-Synuclein; Benzothiazoles; Cell Differentiation; Cell Line, Tumor; Cytoplasm; Ferrous Compounds; Humans; Immunohistochemistry; Molsidomine; Mutation; Neuroblastoma; Oxidative Stress; Parkinson Disease; Proteasome Inhibitors; Reactive Oxygen Species; Rotenone; Thiazoles; Ubiquitin

2006
The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells.
    Neurotoxicity research, 2006, Volume: 10, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Blotting, Western; Cell Fractionation; Cell Line, Tumor; Cell Survival; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Gene Expression; Humans; Neuroblastoma; Neurotoxins; Phosphorylation; Serine; tau Proteins; Tetrazolium Salts; Thiazoles; Transfection

2006
Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro.
    Experimental neurology, 2007, Volume: 203, Issue:2

    Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Female; Humans; Immunoglobulin G; Lewy Body Disease; Male; Microscopy, Electron; Middle Aged; Psychiatric Status Rating Scales; Spectrometry, Fluorescence; tau Proteins; Thiazoles

2007
Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases.
    Neurobiology of disease, 2007, Volume: 25, Issue:2

    Topics: alpha-Synuclein; Antioxidants; Benzothiazoles; beta Carotene; Coenzymes; Humans; Lewy Body Disease; Microscopy, Atomic Force; Microscopy, Electron; Microscopy, Fluorescence; Neurofibrils; Neuroprotective Agents; Parkinson Disease; Thiazoles; Ubiquinone; Vitamin A; Vitamins

2007
Anti-fibrillogenic and fibril-destabilizing activity of nicotine in vitro: implications for the prevention and therapeutics of Lewy body diseases.
    Experimental neurology, 2007, Volume: 205, Issue:2

    Topics: alpha-Synuclein; Benzothiazoles; Humans; Kinetics; Lewy Body Disease; Microfibrils; Microscopy, Atomic Force; Microscopy, Electron; Mutation; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Fluorescence; Thiazoles

2007
Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol.
    Analytical biochemistry, 2007, Aug-15, Volume: 367, Issue:2

    Topics: alpha-Synuclein; Amyloid; Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Humans; Protein Structure, Quaternary; Resveratrol; Spectrometry, Fluorescence; Stilbenes; Thiazoles

2007
Differentiating Alzheimer disease-associated aggregates with small molecules.
    Neurobiology of disease, 2007, Volume: 28, Issue:3

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Mass Spectrometry; Neurofibrillary Tangles; Peptide Library; Plaque, Amyloid; tau Proteins; Thiazines; Thiazoles

2007
In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Sep-26, Volume: 27, Issue:39

    Topics: alpha-Synuclein; Amyloid beta-Peptides; Aniline Compounds; Binding Sites; Cerebral Cortex; Humans; In Vitro Techniques; Lewy Bodies; Lewy Body Disease; Positron-Emission Tomography; Thiazoles

2007
Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein.
    Journal of molecular biology, 2007, Nov-23, Volume: 374, Issue:2

    Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; beta-Synuclein; Fluorescence; Humans; Molecular Sequence Data; Mutation; Protein Conformation; Protein Folding; Sequence Deletion; Sequence Homology, Amino Acid; Thiazoles

2007
Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species.
    The FEBS journal, 2007, Volume: 274, Issue:24

    Topics: alpha-Crystallin B Chain; alpha-Synuclein; Amyloid; Animals; Benzothiazoles; beta-Crystallins; Caseins; Cattle; Chromatography, High Pressure Liquid; Humans; Kinetics; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Molecular Chaperones; Protein Binding; Recombinant Proteins; Temperature; Thiazoles

2007
In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain.
    Journal of neurochemistry, 2008, Volume: 105, Issue:4

    Topics: alpha-Synuclein; Amyloid; Aniline Compounds; Binding Sites; Brain; Humans; Lewy Bodies; Thiazoles

2008
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.
    The Journal of biological chemistry, 2008, Apr-18, Volume: 283, Issue:16

    Topics: alpha-Synuclein; Benzothiazoles; Electrophysiology; Flavanones; Fluorescent Dyes; Gene Expression Regulation; Humans; Iron; Lipid Bilayers; Microscopy, Atomic Force; Microscopy, Confocal; Models, Biological; Parkinson Disease; Protein Binding; Solvents; Thiazoles

2008
Differences between normal and alpha-synuclein overexpressing SH-SY5Y neuroblastoma cells after Abeta(1-42) and NAC treatment.
    Brain research bulletin, 2008, Mar-28, Volume: 75, Issue:5

    Topics: alpha-Synuclein; Alzheimer Disease; Amphotericin B; Amyloid; Amyloid beta-Peptides; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Molecular Weight; Neuroblastoma; Peptide Fragments; Ruthenium Red; Tetrazolium Salts; Thiazoles; Time Factors

2008
Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells.
    Neuroscience letters, 2008, May-09, Volume: 436, Issue:2

    Topics: alpha-Synuclein; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression; Hemin; Humans; Meloxicam; Neuroblastoma; Oxidative Stress; Spectrometry, Fluorescence; Thiazines; Thiazoles; Time Factors; Transfection

2008
Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation.
    Journal of neurochemistry, 2008, Volume: 106, Issue:2

    Topics: alpha-Synuclein; Analysis of Variance; Animals; Benzothiazoles; Cell Death; Cells, Cultured; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Embryo, Mammalian; Formazans; Gene Expression Regulation; Glucose; Mesencephalon; Mice; Mitochondria; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Protein Transport; Receptors, Dopamine D2; Tetrazolium Salts; Thiazoles

2008
Molecular understanding of copper and iron interaction with alpha-synuclein by fluorescence analysis.
    Journal of molecular neuroscience : MN, 2008, Volume: 35, Issue:3

    Topics: alpha-Synuclein; Anilino Naphthalenesulfonates; Benzothiazoles; Binding Sites; Copper; Fluorescence; Fluorescent Dyes; Humans; Iron; Protein Binding; Thiazoles; Tyrosine

2008
Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells.
    Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:11

    Topics: alpha-Synuclein; Analysis of Variance; Benzothiazoles; Cell Count; Cell Differentiation; Cell Fractionation; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Microscopy, Electron, Transmission; Molecular Weight; Neuroblastoma; Neurofilament Proteins; Neurons; Tetracycline; Thiazoles; Time Factors; Transfection; Tretinoin

2008
Real-time analysis of amyloid fibril formation of alpha-synuclein using a fibrillation-state-specific fluorescent probe of JC-1.
    The Biochemical journal, 2009, Mar-01, Volume: 418, Issue:2

    Topics: alpha-Synuclein; Amyloid; Benzimidazoles; Benzothiazoles; Carbocyanines; Computer Systems; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Models, Biological; Protein Binding; Protein Multimerization; Substrate Specificity; Thiazoles

2009
Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?
    Biochimica et biophysica acta, 2009, Volume: 1794, Issue:2

    Topics: alpha-Synuclein; Amino Acid Sequence; Anabasine; Benzothiazoles; Chromatography, Gel; Cotinine; Humans; Hydroquinones; Microscopy, Atomic Force; Molecular Sequence Data; Mutation; Nicotine; Parkinson Disease; Protein Binding; Protein Multimerization; Smoking; Thiazoles

2009
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells.
    Journal of neurochemistry, 2008, Volume: 107, Issue:6

    Topics: alpha-Synuclein; Analysis of Variance; Apoptosis; Cell Line, Tumor; Dopamine; Drug Combinations; Gene Expression Regulation, Neoplastic; Humans; Hydroxycholesterols; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Neuroblastoma; Norepinephrine; Tetrazolium Salts; Thiazoles; Tyrosine 3-Monooxygenase

2008
Dopamine auto-oxidation aggravates non-apoptotic cell death induced by over-expression of human A53T mutant alpha-synuclein in dopaminergic PC12 cells.
    Journal of neurochemistry, 2009, Volume: 108, Issue:3

    Topics: Acetylcysteine; alpha-Synuclein; Animals; Benzimidazoles; Cell Death; Chromatography, High Pressure Liquid; Cysteine; Dopamine; Enzyme Inhibitors; Flow Cytometry; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Humans; Monophenol Monooxygenase; Mutation; Nerve Growth Factor; Oxidation-Reduction; PC12 Cells; Rats; Tetrazolium Salts; Thiazoles; Transfection

2009
Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease.
    The Journal of biological chemistry, 2009, May-08, Volume: 284, Issue:19

    Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Cross-Linking Reagents; Dimerization; Glutamine; Humans; Immunoblotting; Mutagenesis, Site-Directed; Mutation; Parkinson Disease; Protein Conformation; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Transglutaminases

2009
Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro.
    Experimental neurology, 2009, Volume: 217, Issue:2

    Topics: alpha-Synuclein; Benzothiazoles; Estradiol; Estriol; Gonadal Steroid Hormones; Humans; In Vitro Techniques; Lewy Bodies; Lewy Body Disease; Microscopy, Electron; Molecular Structure; Neurofibrils; Neuroprotective Agents; Parkinson Disease; Spectrometry, Fluorescence; Testosterone; Thiazoles

2009
In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.
    European journal of pharmacology, 2009, Sep-01, Volume: 617, Issue:1-3

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzoxazoles; Brain; Fluorine Radioisotopes; Humans; Immunohistochemistry; Lewy Bodies; Lewy Body Disease; Peptide Fragments; Protein Binding; Substrate Specificity; Thiazoles

2009
Domain a' of protein disulfide isomerase plays key role in inhibiting alpha-synuclein fibril formation.
    Cell stress & chaperones, 2010, Volume: 15, Issue:4

    Topics: alpha-Synuclein; Benzothiazoles; Calorimetry; Humans; Protein Disulfide-Isomerases; Protein Structure, Tertiary; Recombinant Proteins; Thiazoles

2010
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia.
    Neurology, 2010, Jan-05, Volume: 74, Issue:1

    Topics: alpha-Synuclein; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Dementia; Female; Humans; Lewy Bodies; Male; Mental Status Schedule; Neurofibrillary Tangles; Parkinson Disease; Positron-Emission Tomography; Prospective Studies; Protein Binding; Severity of Illness Index; tau Proteins; Thiazoles

2010
DnaK/DnaJ/GrpE of Hsp70 system have differing effects on alpha-synuclein fibrillation involved in Parkinson's disease.
    International journal of biological macromolecules, 2010, Mar-01, Volume: 46, Issue:2

    Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Chromatography, Gel; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Molecular Sequence Data; Parkinson Disease; Protein Structure, Quaternary; Thiazoles; Time Factors

2010
A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation.
    Journal of neurochemistry, 2010, Volume: 113, Issue:2

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Calcium Phosphates; Cell Line, Transformed; Humans; Hydrophobic and Hydrophilic Interactions; Inclusion Bodies; Point Mutation; Thiazoles; Transfection

2010
Strategies to increase the reproducibility of protein fibrillization in plate reader assays.
    Analytical biochemistry, 2010, May-15, Volume: 400, Issue:2

    Topics: alpha-Synuclein; Benzothiazoles; Fluorescent Dyes; Humans; Kinetics; Parkinson Disease; Recombinant Proteins; Reproducibility of Results; Sodium Dodecyl Sulfate; Thiazoles

2010
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation.
    Biophysical journal, 2010, Mar-03, Volume: 98, Issue:5

    Topics: alpha-Crystallin B Chain; alpha-Synuclein; Amyloid; Benzothiazoles; Fluorescence; Kinetics; Magnetic Resonance Spectroscopy; Molecular Chaperones; Protein Binding; Protein Structure, Quaternary; Quartz; Thiazoles

2010
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2010, Jun-15, Volume: 25, Issue:8

    Topics: alpha-Synuclein; Benzothiazoles; Fetal Tissue Transplantation; Humans; Lewy Bodies; Longitudinal Studies; Male; Mesencephalon; Microscopy, Electron, Transmission; Middle Aged; Neurons; Parkinson Disease; Postmortem Changes; Thiazoles; Time Factors

2010
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.
    Journal of forensic sciences, 2010, Volume: 55, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Atrophy; Benzothiazoles; Brain; Brain Edema; Cohort Studies; Coroners and Medical Examiners; Female; Forensic Pathology; Frontotemporal Lobar Degeneration; Humans; Hygiene; Ill-Housed Persons; Immunohistochemistry; Male; Malnutrition; Middle Aged; Neurofibrillary Tangles; Neuropil Threads; Plaque, Amyloid; Staining and Labeling; Tauopathies; Thiazoles; Young Adult

2010
In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy.
    Brain : a journal of neurology, 2010, Volume: 133, Issue:Pt 6

    Topics: alpha-Synuclein; Benzoxazoles; Brain; Carbon Radioisotopes; Female; Humans; Immunohistochemistry; Male; Microscopy, Fluorescence; Middle Aged; Multiple System Atrophy; Positron-Emission Tomography; Thiazoles

2010
Dose- and time-dependent alpha-synuclein aggregation induced by ferric iron in SK-N-SH cells.
    Neuroscience bulletin, 2010, Volume: 26, Issue:3

    Topics: alpha-Synuclein; Benzothiazoles; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Ferric Compounds; Humans; Iron; Thiazoles; Time Factors

2010
Isolation of short peptide fragments from alpha-synuclein fibril core identifies a residue important for fibril nucleation: a possible implication for diagnostic applications.
    Biochimica et biophysica acta, 2010, Volume: 1804, Issue:10

    Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Humans; Insulin; Lewy Bodies; Microscopy, Atomic Force; Molecular Sequence Data; Peptide Fragments; Thiazoles

2010
The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.
    Biochemistry, 2010, Sep-21, Volume: 49, Issue:37

    Topics: alpha-Synuclein; Amyloid; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Catechin; Cell Culture Techniques; Diabetes Mellitus, Type 2; Flavonoids; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Phenols; Polyphenols; Protease Nexins; Rats; Receptors, Cell Surface; Thiazoles

2010
Amyloid formation and disaggregation of α-synuclein and its tandem repeat (α-TR).
    Biochemical and biophysical research communications, 2010, Oct-01, Volume: 400, Issue:4

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Catechin; Flavanones; Humans; Imidazoles; Imides; Ionic Liquids; Microscopy, Electron, Transmission; Parkinson Disease; Sulfonamides; Tandem Repeat Sequences; Thiazoles

2010
Characterization of the non-fibrillar α-synuclein oligomers.
    Protein and peptide letters, 2011, Volume: 18, Issue:3

    Topics: alpha-Synuclein; Benzothiazoles; Cell Membrane; Dose-Response Relationship, Drug; Kinetics; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Salts; Solubility; Thiazoles; Unilamellar Liposomes

2011
Amyloid imaging of Lewy body-associated disorders.
    Movement disorders : official journal of the Movement Disorder Society, 2010, Nov-15, Volume: 25, Issue:15

    Topics: Aged; Aged, 80 and over; alpha-Synuclein; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognition; Cognition Disorders; Diagnosis, Differential; Female; Humans; Lewy Bodies; Lewy Body Disease; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Severity of Illness Index; Statistics, Nonparametric; Thiazoles

2010
The role of the C-terminus of human α-synuclein: intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers.
    FEBS letters, 2011, Feb-04, Volume: 585, Issue:3

    Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Cysteine; Cystine; Fluorescent Dyes; Humans; Isomerism; Kinetics; Mutagenesis, Site-Directed; Mutant Proteins; Oxidation-Reduction; Parkinson Disease; Protein Denaturation; Protein Folding; Protein Stability; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles

2011
AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers.
    Journal of neurochemistry, 2011, Volume: 117, Issue:5

    Topics: alpha-Synuclein; Animals; Astrocytes; Cell Death; Cell Survival; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Hippocampus; Humans; Iron; Mice; Microscopy, Confocal; Patch-Clamp Techniques; Receptors, AMPA; Recombinant Proteins; Synaptic Transmission; Tetrazolium Salts; Thiazoles

2011
Coumarin 6 and 1,6-diphenyl-1,3,5-hexatriene (DPH) as fluorescent probes to monitor protein aggregation.
    The Analyst, 2011, May-21, Volume: 136, Issue:10

    Topics: alpha-Synuclein; Benzothiazoles; Carbonic Anhydrases; Coumarins; Diphenylhexatriene; Fluorescent Dyes; Proteins; Quantum Theory; Spectrometry, Fluorescence; Thiazoles

2011
Mechanically functional amyloid fibrils in the adhesive of a marine invertebrate as revealed by Raman spectroscopy and atomic force microscopy.
    Archives of histology and cytology, 2009, Volume: 72, Issue:4-5

    Topics: alpha-Synuclein; Amyloid; Animals; Benzothiazoles; Humans; Microscopy, Atomic Force; Platyhelminths; Protein Structure, Secondary; Spectrum Analysis, Raman; Thiazoles

2009
Dopamine and paraquat enhance α-synuclein-induced alterations in membrane conductance.
    Neurotoxicity research, 2011, Volume: 20, Issue:4

    Topics: alpha-Synuclein; Analysis of Variance; Animals; Cell Line, Tumor; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Doxycycline; Drug Interactions; Gene Expression Regulation; Green Fluorescent Proteins; Heme Oxygenase-1; Herbicides; Humans; Levodopa; Membrane Potentials; Mice; Nerve Tissue Proteins; Neuroblastoma; Paraquat; Patch-Clamp Techniques; Permeability; Tetrazolium Salts; Thiazoles; Transfection; Tubulin; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins

2011
Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state.
    Biochemistry, 2011, Sep-27, Volume: 50, Issue:38

    Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Drug Design; Humans; In Vitro Techniques; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Models, Biological; Models, Molecular; Molecular Sequence Data; Peptides; Protein Folding; Protein Multimerization; Rats; Recombinant Proteins; Thiazoles

2011
Effect of melatonin on α-synuclein self-assembly and cytotoxicity.
    Neurobiology of aging, 2012, Volume: 33, Issue:9

    Topics: alpha-Synuclein; Analysis of Variance; Animals; Antioxidants; Antiparkinson Agents; Benzothiazoles; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Melatonin; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Neurons; Protein Structure, Secondary; Sincalide; Thiazoles; Time Factors; Trihexyphenidyl

2012
Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:6

    Topics: Adult; Aged; alpha-Synuclein; Apoptosis; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Survival; Coloring Agents; Dopaminergic Neurons; Female; Humans; Hydroxyl Radical; In Situ Nick-End Labeling; Iron; Lipid Peroxidation; Male; Melanins; Middle Aged; Oxidative Stress; Risk Factors; Tetrazolium Salts; Thiazoles; Transfection

2012
Detection of α-synuclein aggregates by fluorescence microscopy.
    Rejuvenation research, 2012, Volume: 15, Issue:2

    Topics: alpha-Synuclein; Benzothiazoles; Biomarkers; Circular Dichroism; Dopaminergic Neurons; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Biological; Neurodegenerative Diseases; Parkinson Disease; Recombinant Proteins; Surface Properties; Temperature; Thiazoles

2012
Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.
    Neurochemical research, 2012, Volume: 37, Issue:9

    Topics: Adenine; Alanine; alpha-Synuclein; Animals; Autophagy; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Lysosomes; Microscopy, Electron, Transmission; PC12 Cells; Phagosomes; Phosphoinositide-3 Kinase Inhibitors; Point Mutation; Proteasome Inhibitors; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles; Threonine; Transduction, Genetic; Trehalose; Up-Regulation

2012
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.
    The Journal of biological chemistry, 2012, Aug-17, Volume: 287, Issue:34

    Topics: Acetylation; alpha-Synuclein; Animals; Benzothiazoles; Escherichia coli; HEK293 Cells; HeLa Cells; Humans; Mice; Mice, Knockout; Multiprotein Complexes; Parkinson Disease; Protein Binding; Protein Structure, Secondary; Saccharomyces cerevisiae; Thiazoles

2012
Cross-seeding effects of amyloid β-protein and α-synuclein.
    Journal of neurochemistry, 2012, Volume: 122, Issue:5

    Topics: alpha-Synuclein; Amyloid beta-Peptides; Animals; Benzothiazoles; Chromatography, Gel; Humans; Microscopy, Electron, Scanning; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles

2012
Effects of intravenous immunoglobulin on alpha synuclein aggregation and neurotoxicity.
    International immunopharmacology, 2012, Volume: 14, Issue:4

    Topics: alpha-Synuclein; Benzothiazoles; Cell Line, Tumor; Humans; Immunoglobulins, Intravenous; Microscopy, Electron, Transmission; Neuroblastoma; Neurons; Protein Binding; Protein Conformation; Thiazoles

2012
Rational design of potent domain antibody inhibitors of amyloid fibril assembly.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Dec-04, Volume: 109, Issue:49

    Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Cloning, Molecular; Drug Design; Electrophoresis, Polyacrylamide Gel; Fluorescence; Humans; Immunoblotting; Islet Amyloid Polypeptide; Microscopy, Atomic Force; Molecular Sequence Data; Protein Engineering; Single-Domain Antibodies; Thiazoles

2012
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: alpha-Synuclein; Analysis of Variance; Benzothiazoles; Blotting, Western; Carrier Proteins; Chromatography, Reverse-Phase; DNA Primers; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Confocal; Microscopy, Electron, Transmission; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Phagocytosis; Real-Time Polymerase Chain Reaction; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiazoles; Toll-Like Receptor 2

2013
A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).
    The Journal of biological chemistry, 2013, Jun-14, Volume: 288, Issue:24

    Topics: alpha-Synuclein; Amyloid; Animals; Antiparkinson Agents; Benzothiazoles; Blood-Brain Barrier; Drosophila; Female; Fluorescent Dyes; Hippocampus; HSP70 Heat-Shock Proteins; Humans; Locomotion; Male; Mannitol; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Microscopy, Electron, Transmission; Neocortex; Parkinson Disease; Protein Multimerization; Protein Structure, Secondary; Thiazoles

2013
Wildtype and A30P mutant alpha-synuclein form different fibril structures.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: alpha-Synuclein; Benzothiazoles; Escherichia coli; Fluorescent Dyes; Humans; Kinetics; Microscopy, Electron, Transmission; Mutation; Protein Multimerization; Protein Structure, Secondary; Recombinant Proteins; Scattering, Small Angle; Solutions; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction

2013
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
    Human molecular genetics, 2014, Feb-01, Volume: 23, Issue:3

    Topics: Aging; alpha-Synuclein; Animals; Autophagy; Benzothiazoles; Brain; Carrier Proteins; Gene Expression; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Folding; Solubility; Thiazoles; Ubiquitin

2014
Characterization of polyethylene glycol-polyethyleneimine as a vector for alpha-synuclein siRNA delivery to PC12 cells for Parkinson's disease.
    CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:1

    Topics: alpha-Synuclein; Animals; Apoptosis; Cell Nucleus Shape; Cell Survival; Down-Regulation; Endosomes; Gene Transfer Techniques; Genetic Therapy; Intracellular Space; Neurotoxins; Parkinson Disease; Particle Size; PC12 Cells; Polyethylene Glycols; Polyethyleneimine; Rats; RNA, Messenger; RNA, Small Interfering; Tetrazolium Salts; Thiazoles

2014
In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:2

    Topics: alpha-Synuclein; Antiparkinson Agents; Benzothiazoles; Centella; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Fluorescence; Kinetics; Microscopy, Electron, Transmission; Plant Extracts; Polyphenols; Protein Multimerization; Thiazoles; Triterpenes; Water

2014
Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease.
    The Journal of pathology, 2014, Volume: 232, Issue:5

    Topics: alpha-Synuclein; Animals; Benzothiazoles; Brain; Case-Control Studies; Cognition; Disease Models, Animal; Fluorescent Dyes; Humans; Leukodystrophy, Globoid Cell; Lewy Bodies; Mice; Motor Activity; Mutation; Neurons; Psychosine; Thiazoles

2014
Complexation of amyloid fibrils with charged conjugated polymers.
    Langmuir : the ACS journal of surfaces and colloids, 2014, Apr-08, Volume: 30, Issue:13

    Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Escherichia coli; Fluorocarbon Polymers; Gene Expression; Humans; Kinetics; Microscopy, Atomic Force; Molecular Sequence Data; Protein Aggregates; Recombinant Proteins; Solutions; Spectroscopy, Fourier Transform Infrared; Static Electricity; Thiazoles

2014
Gallic acid interacts with α-synuclein to prevent the structural collapse necessary for its aggregation.
    Biochimica et biophysica acta, 2014, Volume: 1844, Issue:9

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Flocculation; Fluorescent Dyes; Gallic Acid; Humans; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles

2014
Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity.
    Bioorganic & medicinal chemistry letters, 2014, Jul-15, Volume: 24, Issue:14

    Topics: alpha-Synuclein; Amyloid; Artifacts; Benzothiazoles; Humans; Protein Structure, Tertiary; Structure-Activity Relationship; Thiazoles

2014
β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.
    Biochemistry, 2014, Jul-01, Volume: 53, Issue:25

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; beta-Cyclodextrins; Circular Dichroism; Curcumin; Drug Synergism; Fluorescent Dyes; Thiazoles

2014
Amyloids of alpha-synuclein affect the structure and dynamics of supported lipid bilayers.
    Biophysical journal, 2014, Jun-17, Volume: 106, Issue:12

    Topics: Adsorption; alpha-Synuclein; Amyloid; Benzothiazoles; Lipid Bilayers; Liposomes; Mutant Proteins; Phosphatidylcholines; Phosphatidylglycerols; Protein Aggregates; Protein Binding; Staining and Labeling; Thiazoles

2014
Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.
    The Journal of biological chemistry, 2014, Aug-01, Volume: 289, Issue:31

    Topics: alpha-Synuclein; Animals; Benzothiazoles; Biopolymers; Calcium; Electron Transport Complex I; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Thiazoles

2014
Early sodium dodecyl sulfate induced collapse of α-synuclein correlates with its amyloid formation.
    ACS chemical neuroscience, 2015, Feb-18, Volume: 6, Issue:2

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Circular Dichroism; Entropy; Escherichia coli; Fluorescence Resonance Energy Transfer; Glycerol; Microscopy, Electron, Transmission; Mutation; Protein Structure, Secondary; Recombinant Proteins; Sodium Dodecyl Sulfate; Solutions; Solvents; Spectrometry, Fluorescence; Thiazoles; Urea

2015
Binding of the PET radiotracer [¹⁸F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice.
    Current Alzheimer research, 2014, Volume: 11, Issue:10

    Topics: alpha-Synuclein; Animals; Benzoxazoles; Brain Stem; Disease Models, Animal; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Positron-Emission Tomography; Radioligand Assay; Tauopathies; Thalamus; Thiazoles

2014
Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations.
    Molecular neurobiology, 2016, Volume: 53, Issue:3

    Topics: alpha-Synuclein; Antibodies; Benzothiazoles; Biocatalysis; Biological Assay; Circular Dichroism; Fluorescence; Kinetics; Protein Aggregates; Protein Aggregation, Pathological; Thiazoles

2016
CSF proteins and resting-state functional connectivity in Parkinson disease.
    Neurology, 2015, Jun-16, Volume: 84, Issue:24

    Topics: Aged; Aged, 80 and over; alpha-Synuclein; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Brain Mapping; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Activity; Neural Pathways; Parkinson Disease; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; Rest; Severity of Illness Index; Spinal Puncture; Thiazoles

2015
Cu(II) promotes amyloid pore formation.
    Biochemical and biophysical research communications, 2015, Aug-14, Volume: 464, Issue:1

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Cations, Divalent; Copper; Flavanones; Humans; Kinetics; Microscopy, Electron, Transmission; Oxidation-Reduction; Protein Aggregates; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles

2015
Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.
    Scientific reports, 2015, Jul-31, Volume: 5

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Calorimetry; Insulysin; Microscopy, Atomic Force; Protein Multimerization; Thiazoles

2015
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
    Scientific reports, 2015, Nov-19, Volume: 5

    Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Biological Assay; Fluorescence Resonance Energy Transfer; Humans; Kinetics; Molecular Sequence Data; Mutant Proteins; Mutation, Missense; Parkinson Disease; Protein Multimerization; Thiazoles

2015
High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.
    Journal of neuroscience methods, 2016, Mar-01, Volume: 261

    Topics: alpha-Synuclein; Apoptosis; Benzothiazoles; Blotting, Western; Cell Count; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Genetic Vectors; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Indoles; Lentivirus; Microscopy, Fluorescence; Oxidative Stress; Parkinsonian Disorders; Protein Aggregation, Pathological; Protein Multimerization; Software; Thiazoles

2016
Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation.
    Organic letters, 2015, Dec-18, Volume: 17, Issue:24

    Topics: alpha-Synuclein; Amination; Catalysis; Fluorescence; Heterocyclic Compounds, 4 or More Rings; Imines; Molecular Structure; Pyridones; Thiazoles

2015
Conformational Compatibility Is Essential for Heterologous Aggregation of α-Synuclein.
    ACS chemical neuroscience, 2016, 06-15, Volume: 7, Issue:6

    Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Humans; Microscopy, Atomic Force; Molecular Conformation; Thiazoles

2016
Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity.
    Nutrients, 2016, Jun-15, Volume: 8, Issue:6

    Topics: alpha-Synuclein; Animals; Benzothiazoles; Cell Survival; Electrophoresis, Polyacrylamide Gel; Flavonoids; Microscopy, Electron, Transmission; Parkinson Disease; PC12 Cells; Phenols; Rats; Stilbenes; Thiazoles; Wine

2016
Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation.
    Biochimica et biophysica acta, 2016, Volume: 1864, Issue:9

    Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Geum; Humans; Plant Extracts; Protein Aggregates; Solutions; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles

2016
Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation.
    Biochimica et biophysica acta. Proteins and proteomics, 2017, Volume: 1865, Issue:3

    Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Kinetics; Lewy Bodies; Mutation; Parkinson Disease; Protein Aggregation, Pathological; Sequence Alignment; Sheep; Solubility; Thiazoles

2017
Propagation of pathological α-synuclein in marmoset brain.
    Acta neuropathologica communications, 2017, Feb-02, Volume: 5, Issue:1

    Topics: alpha-Synuclein; Animals; Benzothiazoles; Brain; Callithrix; Female; Immunohistochemistry; Lewy Bodies; Microglia; Nerve Degeneration; Neurons; Parkinsonian Disorders; Protein Aggregation, Pathological; Recombinant Proteins; Sequence Homology, Amino Acid; Thiazoles; Tyrosine 3-Monooxygenase

2017
Distinct Mechanisms Determine α-Synuclein Fibril Morphology during Growth and Maturation.
    ACS chemical neuroscience, 2017, 03-15, Volume: 8, Issue:3

    Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Humans; Microscopy, Atomic Force; Multiprotein Complexes; Mutation; Protein Aggregation, Pathological; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Time Factors

2017
Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis.
    ACS chemical neuroscience, 2017, 09-20, Volume: 8, Issue:9

    Topics: alpha-Synuclein; Benzothiazoles; Binding, Competitive; Dose-Response Relationship, Drug; Drug Discovery; Humans; Indoles; Microscopy, Atomic Force; Optical Imaging; Protective Agents; Protein Aggregation, Pathological; Protein Binding; tau Proteins; Thermal Diffusion; Thiazoles

2017
Enzymatic O-GlcNAcylation of α-synuclein reduces aggregation and increases SDS-resistant soluble oligomers.
    Neuroscience letters, 2017, Aug-10, Volume: 655

    Topics: alpha-Synuclein; Benzothiazoles; Humans; N-Acetylglucosaminyltransferases; Protein Aggregates; Protein Multimerization; Protein Processing, Post-Translational; Sodium Dodecyl Sulfate; Solubility; Thiazoles

2017
O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.
    Molecular brain, 2017, 07-19, Volume: 10, Issue:1

    Topics: alpha-Synuclein; Animals; Autophagy; Cells, Cultured; Glucosamine; Glycosylation; Homeostasis; Humans; Models, Biological; Neurons; Parkinson Disease; Phosphorylation; Postmortem Changes; Proto-Oncogene Proteins c-akt; Pyrans; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Thiazoles; TOR Serine-Threonine Kinases

2017
Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T.
    The Journal of biological chemistry, 2017, 10-13, Volume: 292, Issue:41

    Topics: alpha-Synuclein; Benzothiazoles; Humans; Multiprotein Complexes; Protein Aggregation, Pathological; Protein Multimerization; Thiazoles

2017
Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide.
    Physical chemistry chemical physics : PCCP, 2017, Nov-22, Volume: 19, Issue:45

    Topics: alpha-Synuclein; Benzothiazoles; Diabetes Mellitus, Type 2; Humans; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Kinetics; Lysophosphatidylcholines; Microscopy, Electron, Transmission; Molecular Dynamics Simulation; Thiazoles

2017
Amyloid-Beta Radiotracer [
    Contrast media & molecular imaging, 2018, Volume: 2018

    Topics: Aged; alpha-Synuclein; Benzoxazoles; Brain; Female; Fluorine Radioisotopes; Humans; Immunohistochemistry; Male; Multiple System Atrophy; Neuroglia; Positron-Emission Tomography; Thiazoles

2018
Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein.
    Journal of the American Chemical Society, 2018, 04-18, Volume: 140, Issue:15

    Topics: alpha-Synuclein; Benzothiazoles; Ferrous Compounds; Fluorescent Dyes; Humans; Oxidation-Reduction; Parkinson Disease; Thiazoles

2018
Negative 11C-PIB PET Predicts Lack of Alzheimer's Disease Pathology in Postmortem Examination.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 63, Issue:1

    Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Benzothiazoles; Brain; DNA-Binding Proteins; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Sequestosome-1 Protein; tau Proteins; Thiazoles

2018
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
    Acta neuropathologica communications, 2018, 11-26, Volume: 6, Issue:1

    Topics: Aged; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Apolipoproteins E; Brain; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Peptide Fragments; Positron-Emission Tomography; ROC Curve; Statistics, Nonparametric; tau Proteins; Thiazoles

2018
Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils.
    The FEBS journal, 2021, Volume: 288, Issue:2

    Topics: alpha-Synuclein; Amyloid; Amyloidogenic Proteins; Animals; Antigens, Neoplasm; Antiparkinson Agents; Cell Line; Gene Expression Regulation; Glycoside Hydrolase Inhibitors; Histone Acetyltransferases; Humans; Hyaluronoglucosaminidase; Mice; Models, Biological; Neurons; Parkinson Disease; Primary Cell Culture; Protein Aggregates; Protein Transport; Pyrans; RNA, Small Interfering; Thiazoles

2021
XCT 790 is a pharmacological aggrephagy inducer in a yeast model of proteotoxicity.
    Cell biology international, 2021, Volume: 45, Issue:3

    Topics: alpha-Synuclein; Cytoprotection; Indoles; Macroautophagy; Models, Biological; Nitriles; Oximes; Protein Aggregates; Proteolysis; Saccharomyces cerevisiae; Thiazoles

2021
Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.
    European journal of medicinal chemistry, 2022, Jan-05, Volume: 227

    Topics: alpha-Synuclein; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Dyrk Kinases; HEK293 Cells; Humans; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship; Thiazoles; Urea

2022