thiazoles has been researched along with akr 501 in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (6.38) | 29.6817 |
| 2010's | 19 (40.43) | 24.3611 |
| 2020's | 25 (53.19) | 2.80 |
| Authors | Studies |
|---|---|
| Abe, M; Fukushima-Shintani, M; Hirayama, F; Iwatsuki, Y; Kawasaki, T; Sugasawa, K; Suzuki, K | 1 |
| Abe, M; Fukushima-Shintani, M; Hirayama, F; Iwatsuki, Y; Kawasaki, T; Nakahata, T; Sugasawa, K; Suzuki, K | 1 |
| Bussel, JB; Cohn, CS | 1 |
| Abe, M; Hirayama, F; Itoh, H; Kawasaki, T; Koga, Y; Naganuma, S; Sakata, C; Sugasawa, K; Suzuki, K | 1 |
| Basciano, PA; Bussel, J; Christos, PJ; Giannakakou, P; Hafeez, Z | 1 |
| Aledort, LM; Bussel, JB; Cuker, A; Kessler, CM; Kuter, DJ; McIntosh, J; Pendergrass, KB; Tang, S | 1 |
| Hassanein, T; Howell, CD; Jenkins, TM; Joshi, S; Lake, J; McIntosh, J; Sher, L; Tang, S; Terrault, NA; Vargas, H | 1 |
| de Knegt, RJ; Maan, R; Veldt, BJ | 1 |
| Aluri, J; Ferry, J; Han, D; Nomoto, M; Pastino, G; Rege, B | 1 |
| Aluri, J; Boyd, P; Chang, MK; Ferry, J; Lai, WG; Nomoto, M; Rege, B; Schuck, E; Siu, YA; Yasuda, S; Zamora, CA | 1 |
| Ferry, J; Hussein, Z; Nomoto, M | 1 |
| Al-Samkari, H; Kuter, DJ | 1 |
| Shirley, M | 1 |
| Aschenbrenner, DS | 1 |
| Allen, LF; Kuter, DJ | 1 |
| Carmichael, SL; Forde, EE; Frelinger, AL; Michelson, AD; Smolensky Koganov, E | 1 |
| Bussel, JB | 1 |
| Weinberg, EM | 1 |
| Al-Samkari, H | 1 |
| Długosz-Danecka, M; Jurczak, W; Zdziarska, J | 1 |
| Al-Horani, RA; Clemons Bankston, P | 1 |
| Hussar, DA | 1 |
| Flamm, SL; Nilles, KM | 1 |
| Gilreath, JA; Lim, MY | 1 |
| Al-Samkari, H; Kuter, DJ; Virk, ZM | 1 |
| Al, M; Armstrong, N; Buksnys, T; Büyükkaramikli, N; Drachen, T; Duffy, S; Huertas Carrera, V; Kleijnen, J; Penton, H; Raatz, H; Riemsma, R; Ryder, S; Shah, D; Swift, S; Wetzelaer, P; Worthy, G | 1 |
| Gabrail, N; Smith, C | 1 |
| Lozano, ML | 1 |
| Al-Samkari, H; Nagalla, S | 1 |
| Jurczak, W; McCrae, KR; Nazir, J; Pochopien, M; Pustułka, I; Smela, B; Tytuła, A; Vredenburg, M; Wilson, K; Wojciechowski, P | 1 |
| Buscarini, E; Dinis-Ribeiro, M; Fuccio, L; Hassan, C; Radaelli, F | 1 |
| Bussel, JB; Lee, EJ; Seshadri, M | 1 |
| Bubalo, J; Gilreath, J; Lo, M | 1 |
| Allegra, A; Caserta, S; Innao, V; Musolino, C; Zaccuri, AM | 1 |
| Almalki, B; Caicedo, J; Kane, C; Maddur, H; Shroff, H | 1 |
| Markham, A | 1 |
| Kuter, DJ | 1 |
| Chen, M; Jiang, X; Jiang, Z | 1 |
| Maitland, HS | 1 |
| Al-Samkari, H; Jamieson, BD; Kolb-Sielecki, J; Safina, SZ; Xue, X | 1 |
| Arif, AR; Chen, W; Luo, S; Wang, Y; Xue, M; Zhao, M | 1 |
| Al-Samkari, H; Song, AB | 1 |
| Chen, M; Chi, Y; Han, B; Hu, Q; Yang, C | 1 |
| Rodeghiero, F | 1 |
| Fan, HH; Jing, LP; Li, JP; Li, Y; Peng, GX; Xiong, YZ; Yang, WR; Yang, Y; Ye, L; Zhang, FK; Zhang, L; Zhao, X; Zhou, K | 1 |
| Bussel, JB; Jamieson, BD; Lee, EJ; Tarantino, MD | 1 |
| Lebowa, W; Sacha, T; Zdziarska, J | 1 |
15 review(s) available for thiazoles and akr 501
| Article | Year |
|---|---|
Romiplostim: a second-generation thrombopoietin agonist.
Topics: Animals; Carrier Proteins; Humans; Purpura, Thrombocytopenic, Idiopathic; Receptors, Fc; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombopoiesis; Thrombopoietin | 2009 |
Management of Thrombocytopenia in Chronic Liver Disease: Focus on Pharmacotherapeutic Strategies.
Topics: Benzoates; Chronic Disease; Disease Management; Hepatitis C, Chronic; Humans; Hydrazines; Liver Diseases; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoietin | 2015 |
Avatrombopag: First Global Approval.
Topics: Chronic Disease; Drug Approval; Humans; Liver Diseases; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia; United States; United States Food and Drug Administration | 2018 |
Avatrombopag maleate for the treatment of periprocedural thrombocytopenia in patients with chronic liver disease.
Topics: Animals; Chronic Disease; Drug Interactions; Hematologic Agents; Humans; Liver Diseases; Perioperative Period; Thiazoles; Thiophenes; Thrombocytopenia; Treatment Outcome | 2018 |
Avatrombopag for the treatment of immune thrombocytopenia.
Topics: Animals; Blood Platelets; Clinical Trials as Topic; Humans; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Thiazoles; Thiophenes; United States; United States Food and Drug Administration | 2019 |
New Small Molecule Drugs for Thrombocytopenia: Chemical, Pharmacological, and Therapeutic Use Considerations.
Topics: Aminopyridines; Animals; Cinnamates; Drug Development; Humans; Morpholines; Oxazines; Pyridines; Pyrimidines; Receptors, Thrombopoietin; Small Molecule Libraries; Syk Kinase; Thiazoles; Thiophenes; Thrombocytopenia | 2019 |
Thrombocytopenia in Chronic Liver Disease: New Management Strategies.
Topics: Chronic Disease; Cinnamates; Hemorrhage; Humans; Liver Diseases; Platelet Count; Platelet Transfusion; Receptors, Thrombopoietin; Risk Factors; Surgical Procedures, Operative; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoiesis | 2020 |
Avatrombopag and lusutrombopag for thrombocytopenia in people with chronic liver disease needing an elective procedure: a systematic review and cost-effectiveness analysis.
Topics: Bayes Theorem; Cinnamates; Clinical Trials as Topic; Cost-Benefit Analysis; End Stage Liver Disease; Humans; Models, Economic; Platelet Transfusion; Quality-Adjusted Life Years; Receptors, Thrombopoietin; Secondary Care; Technology Assessment, Biomedical; Thiazoles; Thiophenes; Thrombocytopenia | 2020 |
Avatrombopag for the management of thrombocytopenia in patients with chronic liver disease.
Topics: Adult; Chronic Disease; Humans; Liver Diseases; Thiazoles; Thiophenes; Thrombocytopenia | 2021 |
Efficacy and Safety of Avatrombopag in Patients with Chronic Immune Thrombocytopenia: A Systematic Literature Review and Network Meta-Analysis.
Topics: Benzoates; Humans; Network Meta-Analysis; Purpura, Thrombocytopenic, Idiopathic; Randomized Controlled Trials as Topic; Recombinant Fusion Proteins; Thiazoles; Thiophenes | 2021 |
Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations for Pharmacists.
Topics: Benzoates; Cinnamates; Dose-Response Relationship, Drug; Drug Monitoring; Health Knowledge, Attitudes, Practice; Humans; Hydrazines; Pharmacists; Platelet Count; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoietin | 2021 |
Immune thrombocytopenia: options and new perspectives.
Topics: Aminopyridines; Antibodies, Monoclonal, Humanized; COVID-19; Histocompatibility Antigens Class I; Humans; Immunosuppressive Agents; Morpholines; Protein Kinase Inhibitors; Purpura, Thrombocytopenic, Idiopathic; Pyrimidines; Receptors, Fc; Receptors, Thrombopoietin; SARS-CoV-2; Syk Kinase; Thiazoles; Thiophenes | 2021 |
Avatrombopag: A Review in Thrombocytopenia.
Topics: Adult; Animals; Chronic Disease; Humans; Liver Diseases; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia | 2021 |
The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag.
Topics: Anemia, Aplastic; Hepatitis C; Humans; Liver Diseases; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombopoietin | 2022 |
Recent progress in ITP treatment.
Topics: Clinical Trials as Topic; Humans; Purpura, Thrombocytopenic, Idiopathic; Quality of Life; Receptors, Fc; Recombinant Fusion Proteins; Thiazoles; Thrombopoietin | 2023 |
9 trial(s) available for thiazoles and akr 501
| Article | Year |
|---|---|
A randomized trial of avatrombopag, an investigational thrombopoietin-receptor agonist, in persistent and chronic immune thrombocytopenia.
Topics: Administration, Oral; Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drugs, Investigational; Epistaxis; Fatigue; Female; Headache; Humans; Male; Middle Aged; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Time Factors; Treatment Outcome | 2014 |
Phase II study of avatrombopag in thrombocytopenic patients with cirrhosis undergoing an elective procedure.
Topics: Blood Platelets; Dose-Response Relationship, Drug; Double-Blind Method; Elective Surgical Procedures; Fatigue; Female; Headache; Humans; Incidence; Liver Cirrhosis; Male; Middle Aged; Nausea; Platelet Count; Receptors, Thrombopoietin; Risk Factors; Thiazoles; Thiophenes; Thrombocytopenia | 2014 |
Pharmacokinetics, Pharmacodynamics, Pharmacogenomics, Safety, and Tolerability of Avatrombopag in Healthy Japanese and White Subjects.
Topics: Adult; Asian People; Cytochrome P-450 CYP2C9; Fasting; Female; Food-Drug Interactions; Genotype; Humans; Male; Middle Aged; Platelet Count; Receptors, Thrombopoietin; Thiazoles; Thiophenes; White People; Young Adult | 2018 |
Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs.
Topics: Adolescent; Adult; Cytochrome P-450 CYP2C9 Inducers; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Fluconazole; Healthy Volunteers; Humans; Itraconazole; Male; Middle Aged; Platelet Count; Receptors, Thrombopoietin; Rifampin; Thiazoles; Thiophenes; Young Adult | 2018 |
Avatrombopag, an oral thrombopoietin receptor agonist: results of two double-blind, dose-rising, placebo-controlled Phase 1 studies.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia | 2018 |
Avatrombopag increases platelet count but not platelet activation in patients with thrombocytopenia resulting from liver disease.
Topics: Blood Platelets; Chronic Disease; Double-Blind Method; Hematologic Agents; Humans; Liver Diseases; Platelet Activation; Platelet Count; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoiesis; Time Factors; Treatment Outcome; United States | 2018 |
Efficacy and safety evaluation of avatrombopag in immune thrombocytopenia: analyses of a phase III study and long-term extension.
Topics: Double-Blind Method; Female; Humans; Male; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Thiazoles; Thiophenes | 2022 |
Avatrombopag for chemotherapy-induced thrombocytopenia in patients with non-haematological malignancies: an international, randomised, double-blind, placebo-controlled, phase 3 trial.
Topics: Adolescent; Anemia; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Double-Blind Method; Humans; Neutropenia; Thiazoles; Thiophenes; Thrombocytopenia; Treatment Outcome | 2022 |
Plasma gastric biomarker evaluation with avatrombopag dosing in patients with chronic immune thrombocytopenia in phase 3 trials.
Topics: Humans; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Thiazoles; Thrombocytopenia | 2023 |
23 other study(ies) available for thiazoles and akr 501
| Article | Year |
|---|---|
AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis.
Topics: Antigens, CD; Antigens, CD34; Blood Platelets; Cells, Cultured; Colony-Forming Units Assay; Flow Cytometry; Humans; Piperidines; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoiesis; Thrombopoietin | 2008 |
AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist.
Topics: Administration, Oral; Animals; Antigens, CD34; Blood Platelets; Cell Differentiation; Fetal Blood; Hematopoiesis; Humans; Liver; Megakaryocytes; Mice; Mice, Inbred NOD; Mice, SCID; Pan troglodytes; Platelet Count; Ploidies; Polyploidy; Receptors, Thrombopoietin; Recombinant Proteins; Stem Cell Transplantation; Thiazoles; Thiophenes; Thrombopoietin | 2009 |
Pharmacological profile of AS1670542, a novel orally-active human thrombopoietin receptor agonist.
Topics: Administration, Oral; Amino Acid Sequence; Animals; Antigens, CD34; Benzoates; Cell Line; Cell Membrane; Dogs; Female; Histidine; Humans; Hydrazines; Liver; Mice; Molecular Sequence Data; Platelet Count; Protein Structure, Tertiary; Pyrazoles; Rats; Receptors, Thrombopoietin; Species Specificity; Stem Cell Transplantation; Thiazoles; Thiophenes | 2011 |
The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Antibodies, Monoclonal, Murine-Derived; Benzoates; Biomarkers; Child; Child, Preschool; Female; Gene Frequency; Genotype; Humans; Hydrazines; Immunologic Factors; Infant; Male; Middle Aged; Phenotype; Platelet Count; Polymorphism, Single Nucleotide; Purpura, Thrombocytopenic, Idiopathic; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Retrospective Studies; Rituximab; Thiazoles; Thiophenes; Thrombopoiesis; Thrombopoietin; Treatment Failure; Tubulin | 2013 |
Population Pharmacokinetic/Pharmacodynamic Analyses of Avatrombopag in Patients With Chronic Liver Disease and Optimal Dose Adjustment Guide With Concomitantly Administered CYP3A and CYP2C9 Inhibitors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Computer Simulation; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; End Stage Liver Disease; Female; Humans; Male; Middle Aged; Models, Biological; Thiazoles; Thiophenes; Thrombocytopenia; Young Adult | 2018 |
Relative potency of the thrombopoietin receptor agonists eltrombopag, avatrombopag and romiplostim in a patient with chronic immune thrombocytopenia.
Topics: Benzoates; Dose-Response Relationship, Drug; Female; Hematologic Agents; Humans; Hydrazines; Middle Aged; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombopoietin; Treatment Outcome | 2018 |
First Drug Approved to Reduce Bleeding Risk During Medical Procedures in Patients with Chronic Liver Disease.
Topics: Drug Approval; End Stage Liver Disease; Humans; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia | 2018 |
Avatrombopag.
Topics: Humans; Purpura, Thrombocytopenic, Idiopathic; Thiazoles; Thiophenes | 2018 |
What Did We Learn From the ADAPT Trials?
Topics: Humans; Liver Diseases; Platelet Transfusion; Thiazoles; Thiophenes; Thrombocytopenia | 2019 |
New Drugs 2019, part 4.
Topics: Aminopyridines; Cinnamates; Drug Approval; Factor Xa; Humans; Macrolides; Morpholines; Oligonucleotides; Oxazines; Pyridines; Pyrimidines; Recombinant Proteins; RNA, Small Interfering; Sisomicin; Tetracyclines; Thiazoles; Thiophenes; United States; United States Food and Drug Administration | 2019 |
Periprocedural use of avatrombopag for neurosurgical interventions: a strategy to avoid platelet utilization.
Topics: Blood Platelets; Thiazoles; Thiophenes | 2020 |
An evaluation of avatrombopag for the treatment of thrombocytopenia.
Topics: Humans; Liver Diseases; Purpura, Thrombocytopenic, Idiopathic; Thiazoles; Thiophenes; Thrombocytopenia | 2021 |
Avatrombopag Optimizes Response to Niraparib by Managing Thrombocytopenia Associated with Poly-ADP Ribose Polymerase (PARP) Inhibition in Ovarian Cancer and Breast Cancer: A Case Series.
Topics: Adenosine Diphosphate Ribose; Breast Neoplasms; Female; Humans; Indazoles; Ovarian Neoplasms; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thiazoles; Thiophenes; Thrombocytopenia | 2020 |
Second-generation thrombopoietin receptor agonists: New players in the management of cirrhotic patients undergoing therapeutic endoscopy?
Topics: Cinnamates; Endoscopy; Humans; Liver Cirrhosis; Receptors, Thrombopoietin; Surveys and Questionnaires; Thiazoles; Thiophenes; Thrombocytopenia | 2021 |
Clinical outcomes in eight patients with immune thrombocytopenia each treated with the three approved thrombopoietin receptor agonists.
Topics: Adult; Aged; Benzoates; Female; Humans; Hydrazines; Male; Middle Aged; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoietin; Treatment Outcome | 2021 |
Avatrombopag Use in Patient With Thromboembolic Risks Listed for Combined Coronary Artery Bypass Grafting and Liver Transplant: A Case Report.
Topics: Coronary Artery Bypass; Humans; Liver Transplantation; Thiazoles; Thiophenes | 2021 |
Severe aplastic anemia in a patient with erythropoietic protoporphyria successfully treated by avatrombopag.
Topics: Anemia, Aplastic; Humans; Protoporphyria, Erythropoietic; Thiazoles; Thiophenes | 2022 |
Avatrombopag Effectively Maintained Platelet Counts in a Patient with Immune Thrombocytopenia Who Was Intolerant to Tyrosine Kinase Inhibitor Therapy.
Topics: Female; Humans; Middle Aged; Platelet Count; Protein Kinase Inhibitors; Purpura, Thrombocytopenic, Idiopathic; Thiazoles; Thiophenes | 2021 |
Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure.
Topics: Benzoates; Hearing Loss, Sensorineural; Humans; Hydrazines; Male; Molecular Motor Proteins; Mutation; Myosin Heavy Chains; Pyrazoles; Thiazoles; Thiophenes; Thrombocytopenia; Treatment Failure | 2022 |
An updated evaluation of avatrombopag for the treatment of chronic immune thrombocytopenia.
Topics: Humans; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes | 2022 |
Avatrombopag is effective in patients with chemoradiotherapy-induced aplastic anemia: a single-center, retrospective study.
Topics: Aged; Anemia, Aplastic; Chemoradiotherapy; Female; Humans; Male; Middle Aged; Retrospective Studies; Thiazoles | 2023 |
[Avatrombopag combined with standard immunosuppressive therapy in the treatment of severe aplastic anemia with hepatic impairment in six patients].
Topics: Anemia, Aplastic; Antilymphocyte Serum; Cyclosporine; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Thiazoles | 2022 |
Avatrombopag increased platelet count in a patient with chronic immune thrombocytopenia refractory to multiple lines of treatment.
Topics: Adult; Child, Preschool; Humans; Male; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Thiazoles; Thrombocytopenia | 2023 |