Page last updated: 2024-08-21

thiazoles and acridines

thiazoles has been researched along with acridines in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (41.46)	18.7374
1990's	2 (4.88)	18.2507
2000's	15 (36.59)	29.6817
2010's	5 (12.20)	24.3611
2020's	2 (4.88)	2.80

Authors

Authors	Studies
Makoni, SH; Sugden, JK	1
Cantino, EC; Matsumae, A	1
Schwantes, HO	1
Hahn von Dorsche, H; Opitz, M	1
Beliaeva, TN; Braun, AD; Faddeeva, MD	1
Fennessy, MR; Gaff, GA; Woo, JT	1
Fearn, HJ; Fennessy, MR	1
Fennessy, MR	2
Fennessy, MR; Gaff, GA; Heimans, RL	1
Prino, G; Santamaria, L	1
Buu-Hoï, NP; Dufour, M; Jacquignon, P; Martani, A; Ricci, A; Saint-Ruf, G	1
Castagnino, E; Corsano, S; Fioretti, MC; Nocentini, G; Salvatori, A	1
Chiang, HC; Hang, YS; Lu, FJ; Sheu, SY; Shieh, KM; Sun, JS; Tsuang, YH	1
Boven, E; Hoogsteen, IJ; Kohlhagen, G; Maliepaard, M; Pinedo, HM; Pommier, Y; Scheffer, GL; Scheper, RJ; Schlüper, HM; van Hattum, AH	1
Johar, M; Lown, JW; Reddy, BS; Singhal, N; Sondhi, SM	1
BENTLEY, GA; SHAW, FH	1
ADACHI, K; IKEDA, K; MIZUNO, Y	1
KATO, K; TSUBOTA, S; UMEDA, M	1
COURA, LC; DA SILVA, JR; DE CARVALHO, HT; FLORENCIO, C	1
SRAMEK, J	1
Akatsu, H; Kudo, Y; Okamura, N; Sawada, T; Shimadzu, H; Shiomitsu, T; Suemoto, T; Suzuki, M; Yamamoto, T	1
Evtodienko, YV; Kruglov, AG; Yaguzhinsky, LS; Yurkov, IS	1
Avellaneda, A; De Clercq, E; Delmas, F; Di Giorgio, C; Galy, JP; Robin, M; Timon-David, P	1
Honkakoski, P; Urtti, A; Vellonen, KS	1
Cernák, J; Imrich, J; Vilková, M	1
Bajaj, K; Kumar, A; Lahoti, AM; Lozach, O; Meijer, L; Singh, N; Sondhi, SM	1
Inbar, P; Yang, J	1
Chang, HO; Chang, LS; Chou, SY; Hsu, SC; Lee, YJ; Wang, SS; Yin, WK	1
Botta, C; De Méo, M; Decome, L; Di Giorgio, C; Matta, A; Nikoyan, A; Reboul, JP; Robin, M; Sabatier, AS	1
Antalik, M; Bagelova, J; Bellova, A; Daxnerova, Z; Fedunova, D; Gazova, Z; Imrich, J; Kristian, P; Tomascikova, J	1
Asseline, U; Thuong, NT	1
Beijnen, JH; Hillebrand, MJ; Lagas, JS; Lankheet, N; Rosing, H; Schinkel, AH; van Tilburg, VA; van Waterschoot, RA	1
Agarwal, S; Chen, C; Chen, Y; Elmquist, WF; Shaik, NM; Yang, Z	1
Andrieux, K; Brambilla, D; Couvreur, P; Hashemi, SH; Le Droumaguet, B; Moghimi, SM; Nicolas, J; Wu, LP	1
Agarwal, S; Decker, SA; Donelson, R; Elmquist, WF; Gallardo, JL; Mittapalli, RK; Ohlfest, JR; Pokorny, JL; Santacruz, KS; Sarkaria, JN; Seiler, C; Zellmer, DM	1
Elmquist, WF; Mittapalli, RK; Sane, R	1
Bombard, S; Dingli, F; Kaiser, M; Kellermann, G; Lahuna, O; Loew, D; Mahuteau-Betzer, F; Naud-Martin, D; Ségal-Bendirdjian, E; Teulade-Fichou, MP	1
Utkina, NK	1
Alkahtani, HM; Ansari, SA; Bhosle, MR; Bondle, GM; Kharote, SA; Sangshetti, JN	1
Chen, L; Chen, Y; Duan, Y; Feng, F; Huang, J; Jiang, X; Liu, C; Liu, W; Qu, W; Sun, H; Wang, Y; Zhou, J	1

Reviews

4 review(s) available for thiazoles and acridines

Article	Year
Chemotherapy of amoebiasis. Pharmaceutica acta Helvetiae, 1976, Volume: 51, Issue:6 Topics: Acetamides; Acids; Acridines; Alkaloids; Amebiasis; Amines; Anthraquinones; Anti-Bacterial Agents; Cresols; Drug Therapy, Combination; Imidazoles; Male; Organometallic Compounds; Phenanthrolines; Pyridines; Pyrrolidines; Quinolines; Thiazoles	1976
List of the photodynamic substances. Research progress in organic, biological and medicinal chemistry, 1972, Volume: 3 Pt 1 Topics: Acridines; Alkaloids; Anthraquinones; Anti-Bacterial Agents; Benzhydryl Compounds; Benzothiadiazines; Coumarins; Light; Naphthalenesulfonates; Nitroso Compounds; Oxazines; Oxidation-Reduction; Phenazines; Phenothiazines; Photochemistry; Polycyclic Compounds; Pyrones; Quinolines; Stilbenes; Sulfonamides; Thiazines; Thiazoles; Trityl Compounds; Vitamins; Xanthenes	1972
Heterocyclic compounds as inflammation inhibitors. Current medicinal chemistry, 2002, Volume: 9, Issue:10 Topics: Acridines; Alkanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Carboxylic Acids; Gastrointestinal Diseases; Heterocyclic Compounds; Humans; Imidazoles; Pyrimidines; Thiazoles; Thiourea	2002
Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues. Nanomedicine : nanotechnology, biology, and medicine, 2011, Volume: 7, Issue:5 Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biocompatible Materials; Biomarkers; Brain; Chromones; Drug Delivery Systems; Ferric Compounds; Gold; Humans; Magnetite Nanoparticles; Nanoparticles; Thiazoles	2011

Other Studies

37 other study(ies) available for thiazoles and acridines

Article	Year
Sensitivity of the spores of Blastocladiella emersonii and related fungi to antibiotics and some other drugs. The Journal of antibiotics, 1971, Volume: 24, Issue:2 Topics: Acridines; Aniline Compounds; Anti-Bacterial Agents; Antifungal Agents; Antimycin A; Carbamates; Chloramphenicol; Chlortetracycline; Coloring Agents; Cycloheximide; Dactinomycin; Fungi; Mercury; Microbial Sensitivity Tests; Mitomycins; Nitrobenzenes; Nystatin; Phenols; Spores; Staphylococcus; Sulfonic Acids; Tetracycline; Thiazoles; Triazines; Urea	1971
[Microscopic demonstration of micro organisms on membrane filters after filtration of liquids using acridine orange fluorescence]. Zeitschrift fur wissenschaftliche Mikroskopie und mikroskopische Technik, 1971, Volume: 70, Issue:4 Topics: Acridines; Filtration; Methods; Microbiology; Microscopy, Fluorescence; Staining and Labeling; Thiazoles	1971
[Data on the selective fluorochroming of mast cells]. Acta histochemica, 1970, Volume: 36, Issue:1 Topics: Acridines; Animals; Fluoresceins; Fluorescent Dyes; Male; Mast Cells; Microscopy, Fluorescence; Phenazines; Phosphines; Quaternary Ammonium Compounds; Rats; Rosaniline Dyes; Staining and Labeling; Thiazoles	1970
[Effect of basic dyes, including dyes intercalating with DNA, on the adenosine triphosphatase activity of mitochondria]. Tsitologiia, 1974, Volume: 16, Issue:6 Topics: Acridines; Adenosine Triphosphatases; Animals; Coloring Agents; Dimethylamines; Ethidium; In Vitro Techniques; Mitochondria, Liver; Phenazines; Quaternary Ammonium Compounds; Rats; Stimulation, Chemical; Thiazoles; Xanthenes	1974
A note on the effects of 2,4-diamino-5-phenylthiazole and 1, 2, 3, 4-tetrahydro-9-aminoacridine on morphine metabolism. The Journal of pharmacy and pharmacology, 1968, Volume: 20, Issue:10 Topics: Acridines; Chromatography, Paper; Humans; Methods; Morphine; Spectrophotometry; Thiazoles	1968
Some observations on the toxicology of morphine-N-oxide. The Journal of pharmacy and pharmacology, 1969, Volume: 21, Issue:10 Topics: Acridines; Animals; Body Weight; Female; Fetus; Growth; Morphinans; Morphine; Nalorphine; Oxides; Pregnancy; Rats; Spleen; Stomach; Thiazoles	1969
The behavioural, cardiovascular and respiratory actions of morphine-N-oxide in the dog. European journal of pharmacology, 1969, Volume: 8, Issue:3 Topics: Acridines; Animals; Arousal; Atropine; Behavior, Animal; Blood Pressure; Cardiovascular System; Carotid Arteries; Cyclic N-Oxides; Dogs; Heart Rate; Histamine H1 Antagonists; Injections, Intravenous; Injections, Subcutaneous; Morphinans; Morphine; Nalorphine; Pyridines; Respiration; Thiazoles	1969
Some aspects of the metabolism of morphine-N-oxide. The Journal of pharmacy and pharmacology, 1971, Volume: 23, Issue:11 Topics: Acridines; Analgesics; Animals; Codeine; Cyclic N-Oxides; In Vitro Techniques; Injections, Intraperitoneal; Liver; Male; Methylation; Morphinans; Morphine; Rats; Thiazoles	1971
The analgesic action of morphine-n-oxide. British journal of pharmacology, 1968, Volume: 34, Issue:2 Topics: Acridines; Analgesia; Animals; Cyclic N-Oxides; Hot Temperature; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Morphine; Pain; Rats; Tail; Thiazoles	1968
Carcinogenic nitrogen compounds. 53. Thiazole isosteres of dibenzacridines and dibenzocarbazoles. Journal of the Chemical Society. Perkin transactions 1, 1966, Volume: 20 Topics: Acridines; Azoles; Carcinogens; Chemical Phenomena; Chemistry; Thiazoles	1966
In vitro evaluation of the potential antitumor activity of an N-acridyl-pentanoyloxypyridine-2-thione derivative. Arzneimittel-Forschung, 1995, Volume: 45, Issue:10 Topics: Acridines; Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Leukemia L1210; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	1995
Scavenging effect of benzophenones on the oxidative stress of skeletal muscle cells. Free radical biology & medicine, 1999, Volume: 26, Issue:9-10 Topics: Acridines; Animals; Benzophenones; Cell Survival; Drug Evaluation, Preclinical; Free Radical Scavengers; Humans; In Vitro Techniques; Luminescent Measurements; Luminol; Muscle, Skeletal; Oxidative Stress; Rats; Sunscreening Agents; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Vitamin K	1999
Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity. British journal of cancer, 2002, Sep-09, Volume: 87, Issue:6 Topics: Acridines; Animals; Antigens, CD; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Cell Division; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Female; Humans; Immunoenzyme Techniques; Isoquinolines; Membrane Glycoproteins; Mice; Mice, Nude; Mutation; Neoplasm Proteins; Neoplasms, Experimental; Ovarian Neoplasms; Tetrahydroisoquinolines; Tetraspanin 29; Tetrazolium Salts; Thiazoles; Topoisomerase I Inhibitors; Tumor Cells, Cultured	2002
The pharmacology of some new anti-cholinesterases. The Australian journal of experimental biology and medical science, 1953, Volume: 31, Issue:6 Topics: Acridines; Cholinesterase Inhibitors; Coloring Agents; Pyridines; Thiazoles	1953
Studies on condensed systems of aromatic nitrogenous series. XIII. Extension of malonic ester synthesis to the heterocyclic series. Pharmaceutical bulletin, 1954, Volume: 2, Issue:3 Topics: Acridines; Coloring Agents; Esters; Nitrogen; Quinolines; Thiazoles	1954
[COLORIMETRIC DETERMINATION OF ACRINOL]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1963, Volume: 83 Topics: Acridines; Chemistry, Pharmaceutical; Colorimetry; Ethacridine; Pharmacy; Research; Thiazoles	1963
[GIARDIASIS. COMPARATIVE STUDY OF THE TOLERANCE AND THERAPEUTIC EFFECTIVENESS OF VARIOUS PRODUCTS]. Hospital (Rio de Janeiro, Brazil), 1964, Volume: 65 Topics: Acridines; Anti-Infective Agents, Local; Antiprotozoal Agents; Biomedical Research; Drug Tolerance; Furazolidone; Giardiasis; Humans; Metronidazole; Pharmacology; Thiazoles	1964
PAPER CHROMATOGRAPHY OF DYES. IV. PAPER CHROMATOGRAPHY OF WATER-SOLUBLE DYES. Journal of chromatography, 1964, Volume: 14 Topics: Acridines; Anthraquinones; Azo Compounds; Chromatography; Chromatography, Paper; Coloring Agents; Research; Stilbenes; Thiazines; Thiazoles; Water; Xanthenes	1964
In vivo labeling of amyloid with BF-108. Neuroscience research, 2004, Volume: 48, Issue:1 Topics: Acridines; Affinity Labels; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Brain; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Neurofibrillary Tangles; Plaque, Amyloid; Rats; Rats, Wistar; Thiazoles	2004
Mechanism of superoxide anion generation in intact mitochondria in the presence of lucigenin and cyanide. Biochemistry. Biokhimiia, 2003, Volume: 68, Issue:12 Topics: Acridines; Adenosine Triphosphate; Animals; Antimycin A; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Respiration; Cyanides; Cyclosporine; Kinetics; Luminescent Measurements; Methacrylates; Mitochondria, Liver; Oligomycins; Oxygen; Oxygen Consumption; Proton-Motive Force; Rats; Rats, Wistar; Spectrometry, Fluorescence; Succinic Acid; Superoxides; Thiazoles; Uncoupling Agents	2003
Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives. European journal of medicinal chemistry, 2004, Volume: 39, Issue:8 Topics: Acridines; Acridones; Animals; Antiprotozoal Agents; Benzothiazoles; Humans; Leishmania infantum; Thiazoles	2004
Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2004, Volume: 23, Issue:2 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cattle; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Humans; L-Lactate Dehydrogenase; Multidrug Resistance-Associated Proteins; Oxidation-Reduction; Propionates; Quinolines; Tetrahydroisoquinolines; Tetrazolium Salts; Thiazoles; Verapamil	2004
2-(Acridin-9-ylimino)-3-dimethylamino-1,3-thiazolidin-4-one. Acta crystallographica. Section C, Crystal structure communications, 2005, Volume: 61, Issue:Pt 4 Topics: Acridines; Crystallography, X-Ray; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Structure; Thiazoles	2005
Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities. Bioorganic & medicinal chemistry, 2005, Jul-01, Volume: 13, Issue:13 Topics: Acridines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Brain; Carrageenan; CDC2 Protein Kinase; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Edema; Enzyme Inhibitors; Female; Glycogen Synthase Kinase 3; Mice; Pain Measurement; Rats; Swine; Thiazoles	2005
Inhibiting protein-amyloid interactions with small molecules: a surface chemistry approach. Bioorganic & medicinal chemistry letters, 2006, Feb-15, Volume: 16, Issue:4 Topics: Acridines; Amyloid; Benzothiazoles; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Molecular Structure; Proflavine; Protein Binding; Proteins; Surface Properties; Thiazoles	2006
Linker-modified triamine-linked acridine dimers: synthesis and cytotoxicity properties in vitro and in vivo. Bioorganic & medicinal chemistry, 2007, Jan-15, Volume: 15, Issue:2 Topics: Acridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA; Humans; Indicators and Reagents; Intercalating Agents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Inbred ICR; Mice, SCID; Nitrogen; Plasmids; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles	2007
DNA-damaging activity and mutagenicity of 16 newly synthesized thiazolo[5,4-a]acridine derivatives with high photo-inducible cytotoxicity. Mutation research, 2008, Feb-29, Volume: 650, Issue:2 Topics: Acridines; Cell Survival; Cells, Cultured; DNA Damage; Humans; Intercalating Agents; Light; Mutagenicity Tests; Mutagens; Quantitative Structure-Activity Relationship; Thiazoles	2008
Acridine derivatives inhibit lysozyme aggregation. European biophysics journal : EBJ, 2008, Volume: 37, Issue:7 Topics: Acridines; Amyloid; Animals; Benzothiazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Molecular Weight; Muramidase; Protein Binding; Small Molecule Libraries; Thiazoles; Time Factors	2008
Incorporation of halogenoalkyl, 2-pyridyldithioalkyl, or isothiocyanate linkers into ligands. Current protocols in nucleic acid chemistry, 2001, Volume: Chapter 4 Topics: Acridines; Biochemistry; Ficusin; Hydrocarbons, Halogenated; Isothiocyanates; Ligands; Phenanthrolines; Pyridines; Thiazoles	2001
Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Apr-01, Volume: 15, Issue:7 Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Brain; Cell Line; Dasatinib; Dogs; Mice; Mice, Knockout; Protein Kinase Inhibitors; Pyrimidines; Tetrahydroisoquinolines; Thiazoles	2009
P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:3 Topics: Acridines; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Cell Line; Cell Membrane Permeability; Dasatinib; Dibenzocycloheptenes; Dogs; Drug Resistance, Neoplasm; Indicators and Reagents; Mass Spectrometry; Mice; Mice, Knockout; Neurons; Protein Kinase Inhibitors; Pyrimidines; Quinolines; Tetrahydroisoquinolines; Thiazoles; Vinblastine	2009
Active efflux of Dasatinib from the brain limits efficacy against murine glioblastoma: broad implications for the clinical use of molecularly targeted agents. Molecular cancer therapeutics, 2012, Volume: 11, Issue:10 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Dasatinib; Disease Models, Animal; Endothelium, Vascular; Glioblastoma; Humans; Mice; Mice, Knockout; Molecular Targeted Therapy; Oncogenes; Permeability; Pyrimidines; Signal Transduction; Survival Analysis; Tetrahydroisoquinolines; Thiazoles; Tight Junctions; Tissue Distribution; Treatment Outcome; Xenograft Model Antitumor Assays	2012
Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability. Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:4 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Biological Transport; Brain; Cell Line; Dasatinib; Dogs; Drug Delivery Systems; Emulsions; Erlotinib Hydrochloride; Humans; Mice; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Solubility; Tetrahydroisoquinolines; Thiazoles	2013
Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT. Nucleic acids research, 2015, Sep-03, Volume: 43, Issue:15 Topics: Acridines; Genetic Techniques; HEK293 Cells; Humans; Niacinamide; Recombinant Fusion Proteins; RNA; RNA Folding; Small Molecule Libraries; Structure-Activity Relationship; Telomerase; Thiazoles; Trisaccharides	2015
Sagitol D, a New Thiazole Containing Pyridoacridine Alkaloid from a Vietnamese Ascidian. Natural product communications, 2015, Volume: 10, Issue:9 Topics: Acridines; Alkaloids; Animals; Molecular Structure; Phenanthrolines; Thiazoles; Urochordata; Vietnam	2015
Organocatalyzed Domino Synthesis of New Thiazole-Based Decahydroacridine-1,8-diones and Dihydropyrido[2,3-d : 6,5-d']- dipyrimidines in Water as Antimicrobial Agents. Chemistry & biodiversity, 2020, Volume: 17, Issue:2 Topics: Acridines; Anti-Infective Agents; Aspergillus; Candida; Catalysis; Gram-Negative Bacteria; Gram-Positive Bacteria; Pyridines; Sulfonic Acids; Thiazoles; Water	2020
Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease. European journal of medicinal chemistry, 2020, Dec-01, Volume: 207 Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Glycogen Synthase Kinase 3; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Morris Water Maze Test; Phosphorylation; Protein Conformation; tau Proteins; Thiazoles	2020