Compounds > thiazoles
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thiazoles and 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde o-(3,4-dichlorobenzyl)oxime

thiazoles has been researched along with 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde o-(3,4-dichlorobenzyl)oxime in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (24.14)29.6817
2010's21 (72.41)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Billin, AN; Collins, JL; Goodwin, B; Kliewer, SA; Lambert, MH; Maglich, JM; Moore, JT; Moore, LB; Parks, DJ; Stoltz, CA; Willson, TM1
Collins, JL; Lambert, MH; Moore, JT; Moore, LB; Waitt, GM; Warren, EN; Weinert, EE; Williams, JD; Willson, TM; Wisely, BB; Xu, RX1
Faucette, SR; Lecluyse, EL; Negishi, M; Smith, CM; Sueyoshi, T; Wang, H1
Friis, C; Gillberg, M; Skaanild, MT1
Auerbach, SS; Dekeyser, JG; Omiecinski, CJ; Stoner, MA1
Anzenbacher, P; Anzenbacherova, E; Cerveny, L; Dvorak, Z; Pavek, P; Staud, F; Svecova, L; Ulrichova, J; Vrzal, R1
Boursier-Neyret, C; Cloarec, O; Croixmarie, V; Moreau, A; Pascussi, JM; Umbdenstock, T; Walther, B1
Breuker, C; Lakhal, L; Lumbroso, S; Maurel, P; Meyer, U; Moreau, A; Parmentier, Y; Pascussi, JM; Tamasi, V; Vilarem, MJ1
Hiramatsu, Y; Masuyama, H; Nakatsukasa, H1
Jeong, H; Koh, KH; Yang, K1
Boursier-Neyret, C; Cloarec, O; Croixmarie, V; Moreau, A; Parmentier, Y; Pascussi, JM; Umbdenstock, T; Walther, B1
Bright, JJ; Chakraborty, S; Kanakasabai, S1
Chen, T; Kannuswamy, M; Laurenzana, EM; Li, Y; Omiecinski, CJ; Sell, BE; Strom, SC1
Bele, P; Galla, HJ; Lemmen, J; Tozakidis, IE1
Hu, HH; Xu, C; Xu, SY; Yu, LS; Zeng, S1
Inouye, Y; Kanno, Y; Takahashi, A; Tanuma, N1
Garzel, B; Heyward, S; Moeller, T; Shapiro, P; Wang, H; Yang, H1
Dagli, ML; De Carvalho, DD; Fukumasu, H; Mesquita, LG; Pires, PR; Rochetti, AL; Silva, ER; Strefezzi, RF1
Carazo, A; Pávek, P1
Brayman, TG; Huang, SM; Li, D; Mackowiak, B; Mitchell, M; Wang, H; Zhang, L1
Baer, MR; Hassan, HE; Hedrich, WD; Heyward, S; Wang, H; Xiao, J; Zhang, J; Zhang, Y1
Burk, O; Damm, G; Kandel, BA; Schwab, M; Seehofer, D; Thomas, M; Winter, S; Zanger, UM1
Inaba, M; Inouye, Y; Kanno, Y; Nakamura, S; Nemoto, K; Tanuma, N; Yazawa, S; Zhao, S1
Lynch, C; Wang, H; Xia, M; Zhao, J1
Andersen, ME; Cowie, DE; Deisenroth, C; LeCluyse, E; Peffer, RC; Soldatow, V; Trask, OJ1
Alston, L; Altier, C; Chang, TK; Erickson, SL; Flannigan, KL; Ghosh, S; Hirota, CL; Hirota, SA; Hudson, GM; Mani, S; Rioux, KP; Vicentini, FA; Zamponi, A1
Briolotti, P; Daujat-Chavanieu, M; de Boussac, H; Duret, C; Fabre, JM; Gerbal-Chaloin, S; Gondeau, C; Herrero, A; Maurel, P; Ramos, J; Römer, M; Templin, M; Treindl, F1
Mazin, ME; Prokopyeva, EA; Pustylnyak, VO; Pustylnyak, YA; Yarushkin, AA1
Bwayi, M; Chai, SC; Chen, T; Huber, AD; Li, Y; Lin, W; Wu, J1

Other Studies

29 other study(ies) available for thiazoles and 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde o-(3,4-dichlorobenzyl)oxime

ArticleYear
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.
    The Journal of biological chemistry, 2003, May-09, Volume: 278, Issue:19

    Topics: Cells, Cultured; Constitutive Androstane Receptor; Gene Expression Regulation; Hepatocytes; Humans; Oximes; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Transcription Factors

2003
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.
    Molecular cell, 2004, Dec-22, Volume: 16, Issue:6

    Topics: Binding Sites; Constitutive Androstane Receptor; Dimerization; Humans; Ligands; Oximes; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptor alpha; Thiazoles; Transcription Factors

2004
Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Base Sequence; Cell Line, Tumor; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Enzymologic; Genes, Reporter; Hepatocytes; Humans; Liver; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Oximes; Pregnane X Receptor; Protein Binding; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; Thiazoles; Transcription Factors

2006
Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Constitutive Androstane Receptor; Coumarins; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Liver; Male; Orchiectomy; Oximes; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Sex Factors; Steroid Hydroxylases; Swine; Swine, Miniature; Thiazoles; Transcription Factors

2006
CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:3

    Topics: Androstanols; Animals; Binding Sites; Chlorocebus aethiops; Clotrimazole; Constitutive Androstane Receptor; COS Cells; Genes, Reporter; Humans; Ligands; Luciferases; Mutagenesis, Site-Directed; Oximes; Receptors, Cytoplasmic and Nuclear; Response Elements; Retinoid X Receptor alpha; Thiazoles; Transcription Factors; Transfection

2007
Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Synergism; Electrophoretic Mobility Shift Assay; Enzyme Induction; Genes, Reporter; Hepatocytes; Humans; Hydroxylation; Luciferases; Oxidoreductases, N-Demethylating; Oximes; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Retinoid X Receptor alpha; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Testosterone; Thiazoles; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Up-Regulation; Valproic Acid

2007
Integrated comparison of drug-related and drug-induced ultra performance liquid chromatography/mass spectrometry metabonomic profiles using human hepatocyte cultures.
    Analytical chemistry, 2009, Aug-01, Volume: 81, Issue:15

    Topics: Biomarkers; Chromatography, Liquid; Constitutive Androstane Receptor; Excitatory Amino Acid Antagonists; Hepatocytes; Humans; Mass Spectrometry; Metabolomics; Nucleic Acid Synthesis Inhibitors; Oximes; Phenobarbital; Rifampin; Thiazoles

2009
Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).
    Endocrinology, 2010, Volume: 151, Issue:4

    Topics: Adult; Aged; Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Constitutive Androstane Receptor; Electrophoretic Mobility Shift Assay; Female; Gene Expression Regulation; Humans; Liver; Male; Mice; Middle Aged; Nuclear Proteins; Oximes; Phenobarbital; Promoter Regions, Genetic; Pyridines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Transcription Factors; Transcriptional Activation; Transfection

2010
Effect of oncostatin M on uridine diphosphate-5'-glucuronosyltransferase 1A1 through cross talk with constitutive androstane receptor.
    Molecular endocrinology (Baltimore, Md.), 2010, Volume: 24, Issue:4

    Topics: Animals; Animals, Newborn; Blotting, Western; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Flavonoids; Glucuronosyltransferase; Hep G2 Cells; Humans; Infant, Newborn; Jaundice, Neonatal; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Oncostatin M; Oximes; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles

2010
Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes.
    Drug metabolism letters, 2010, Volume: 4, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Oxidoreductases, N-Demethylating; Oximes; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Rifampin; RNA, Messenger; Thiazoles; Transcriptional Activation; Transfection; Triazoles

2010
Metabonomic studies on human hepatocyte in primary culture.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 640

    Topics: Cells, Cultured; Constitutive Androstane Receptor; Hepatocytes; Humans; Mass Spectrometry; Metabolomics; Models, Biological; Oximes; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Thiazoles

2010
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells.
    British journal of cancer, 2011, Feb-01, Volume: 104, Issue:3

    Topics: Animals; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Proliferation; Constitutive Androstane Receptor; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Oximes; Receptors, Cytoplasmic and Nuclear; Thiazoles; Xenograft Model Antitumor Assays

2011
The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).
    Molecular pharmacology, 2012, Volume: 82, Issue:5

    Topics: Amino Acid Sequence; Aryl Hydrocarbon Hydroxylases; Co-Repressor Proteins; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; DAX-1 Orphan Nuclear Receptor; Genes, Reporter; Hepatocytes; Humans; Immunoprecipitation; Luciferases; Molecular Sequence Data; Mutation; Oxidoreductases, N-Demethylating; Oximes; Primary Cell Culture; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription, Genetic; Transcriptional Activation; Two-Hybrid System Techniques

2012
Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood-brain barrier after CITCO activation.
    Brain research, 2013, Mar-21, Volume: 1501

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Cells, Cultured; Constitutive Androstane Receptor; Endothelial Cells; Endothelium, Vascular; Oximes; Receptors, Cytoplasmic and Nuclear; Swine; Thiazoles; Up-Regulation

2013
[Establishment of in vitro evaluation model for CYP2B6 induction and its application to screen inducers among TCMs].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:1

    Topics: Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Drugs, Chinese Herbal; Genes, Reporter; Genetic Vectors; Hep G2 Cells; High-Throughput Screening Assays; Humans; Luciferases; Oximes; Plants, Medicinal; Plasmids; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Thiazoles; Transfection

2013
TO901317, a potent LXR agonist, is an inverse agonist of CAR.
    The Journal of toxicological sciences, 2013, Volume: 38, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Enzyme Induction; Genetic Variation; Humans; Hydrocarbons, Fluorinated; Liver X Receptors; Mice; Nuclear Receptor Coactivator 1; Orphan Nuclear Receptors; Oxidoreductases, N-Demethylating; Oximes; Rats; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Sulfonamides; Thiazoles; Transcription, Genetic

2013
Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.
    Molecular pharmacology, 2014, Volume: 85, Issue:2

    Topics: Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Dose-Response Relationship, Drug; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Hypoglycemic Agents; Metformin; Oximes; p38 Mitogen-Activated Protein Kinases; Phenobarbital; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles

2014
Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Androstenols; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Constitutive Androstane Receptor; DNA Modification Methylases; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Oximes; Paclitaxel; Pyridines; Receptors, Cytoplasmic and Nuclear; Thiazoles; WT1 Proteins

2014
The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists.
    Sensors (Basel, Switzerland), 2015, Apr-21, Volume: 15, Issue:4

    Topics: Biological Assay; Cell Line, Tumor; Clotrimazole; Constitutive Androstane Receptor; Humans; Isoquinolines; Oximes; Receptors, Cytoplasmic and Nuclear; Thiazoles

2015
Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells.
    Biochemical pharmacology, 2015, Nov-01, Volume: 98, Issue:1

    Topics: Constitutive Androstane Receptor; Excitatory Amino Acid Antagonists; Gene Deletion; Gene Expression Regulation; Genome-Wide Association Study; Humans; Oximes; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcriptome

2015
Activation of the Constitutive Androstane Receptor Increases the Therapeutic Index of CHOP in Lymphoma Treatment.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Coculture Techniques; Constitutive Androstane Receptor; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Gene Expression Regulation, Neoplastic; Hepatocytes; Histones; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Oxidative Stress; Oximes; Phosphorylation; Prednisone; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Vincristine

2016
Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.
    Biochimica et biophysica acta, 2016, Volume: 1859, Issue:9

    Topics: Adult; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Genome-Wide Association Study; Hepatocytes; Humans; Inactivation, Metabolic; Ligands; Male; Metabolic Networks and Pathways; Middle Aged; Molecular Sequence Annotation; Oximes; PPAR alpha; Pregnane X Receptor; Primary Cell Culture; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Signal Transduction; Thiazoles; Transcriptome

2016
Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8

    Topics: Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Partial Agonism; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Hep G2 Cells; Humans; Isoquinolines; Ligands; Oximes; Pregnane X Receptor; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; RNA, Messenger; Thiazoles; Transfection

2016
Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators.
    Methods in molecular biology (Clifton, N.J.), 2016, Volume: 1473

    Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Cell Line; Cell Nucleus; Cell Survival; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytoplasm; Founder Effect; Gene Expression Regulation; Hep G2 Cells; High-Throughput Screening Assays; Humans; Isoquinolines; Luciferases; Oximes; Plasmids; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transfection

2016
Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.
    Toxicology in vitro : an international journal published in association with BIBRA, 2016, Volume: 36

    Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Cell Proliferation; Cell Survival; Cells, Cultured; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; DNA; Epidermal Growth Factor; Hepatocytes; Humans; Male; Membrane Proteins; Mice; Microscopy, Fluorescence; Oximes; Phenobarbital; Pyridines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Species Specificity; Steroid Hydroxylases; Thiazoles

2016
Constitutive androstane receptor regulates the intestinal mucosal response to injury.
    British journal of pharmacology, 2017, Volume: 174, Issue:12

    Topics: Animals; Caco-2 Cells; Cell Proliferation; Cells, Cultured; Colitis; Constitutive Androstane Receptor; Dextran Sulfate; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oximes; Pyridines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Wound Healing

2017
Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:3

    Topics: Adult; Aged; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Hepatocytes; Humans; Male; Middle Aged; Oximes; Peroxisome-Targeting Signal 1 Receptor; Phenobarbital; Recoverin; Signal Transduction; Thiazoles; Transcription, Genetic

2018
Promotion of liver growth by CAR is accompanied by Akt pathway activation and FoxM1-Nedd4-mediated repression of PTEN.
    Archives of biochemistry and biophysics, 2019, 09-15, Volume: 672

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P450 Family 2; Forkhead Box Protein M1; Gene Expression; Liver; Male; Mice, Inbred C57BL; Nedd4 Ubiquitin Protein Ligases; Oximes; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Steroid Hydroxylases; Thiazoles

2019
CITCO Directly Binds to and Activates Human Pregnane X Receptor.
    Molecular pharmacology, 2020, Volume: 97, Issue:3

    Topics: Dose-Response Relationship, Drug; Gene Knockout Techniques; HEK293 Cells; Hep G2 Cells; Humans; Oximes; Pregnane X Receptor; Protein Binding; Thiazoles

2020