Page last updated: 2024-08-21

thiazoles and 2-aminothiazole

thiazoles has been researched along with 2-aminothiazole in 119 studies

Research

Studies (119)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (7.56)	18.7374
1990's	4 (3.36)	18.2507
2000's	22 (18.49)	29.6817
2010's	62 (52.10)	24.3611
2020's	22 (18.49)	2.80

Authors

Authors	Studies
Ruenitz, PC; Ruzicka, JA	1
Fowler, M; Furfine, ES; Garvey, EP; Harmon, MF; Marshall, S; Oplinger, JA; Paith, JE; Sherman, PA; Tanoury, GJ	1
Goodin, DB; Musah, RA	1
Giordano, H; Liang, L; Peterson, MG; Sivaraja, M; Spector, FC	1
Leung, SS; Porco, JA; Yun, YK	1
Bone, R; DesJarlais, RL; Grasberger, B; Green, D; Hoffman, JB; Illig, CR; Lewandowski, FA; Maguire, D; Molloy, CJ; Randall, T; Rudolph, MJ; Sharp, C; Soll, R; Spurlino, J; Subasinghe, N; Wilson, KJ; Zhang, M; Zhou, Z	1
Ewington, J; Lynch, DE	1
Chordia, MD; Linden, J; Macdonald, TL; Murphree, LJ; Olsson, RA	1
Fleming, PJ; Gillet, VJ; Green, DV; Willett, P	1
Giannis, A; Mazitschek, R; Soric, N; Stieber, F; Waldmann, H	1
Alcântara, IL; Castro, GR; Padilha, CC; Padilha, PM; Rocha, JC; Roldan, PS	1
Karasyova, EI; Metelitza, DI; Naumchik, IV	1
Lah, N; Leban, I; Majcen Le Maréchal, A; Toplak, R; Volmajer, J	1
TRAVE, R	1
TAJIKA, Y	2
TAZIKA, Y	2
Ido, M; Kawasaki, M; Terauchi, H; Ueda, S; Yano, A	1
Alcântara, IL; Castro, GR; Moraes, FV; Oliveira, JD; Padilha, CC; Padilha, PM; Roldan, PS; Silva, FA	1
TELO, W	1
Adam, M; Ahlijanian, MK; Cooper, CB; Gant, T; Helal, CJ; Kang, Z; Kelly, K; Kupchinsky, S; Lucas, JC; Menniti, FS; Peterson, M; Sanner, MA; Tate, B	1
Bolger, G; Bousquet, C; Cordingley, MG; Faucher, AM; Garneau, M; Harji, F; Kibler, P; Lapeyre, N; Liuzzi, M; McCollum, RS; Simoneau, B	1
Brussee, J; Göblyös, A; Ijzerman, AP; Mulder-Krieger, T; Pietra, D; Santiago, SN; von Frijtag Drabbe Künzel, J	1
Cheng, CY; Jiang, FC	1
Padilha, PM; Santos, AL; Stradiotto, NR; Takeuchi, RM	1
Bercot, EA; Caille, S; Cui, S; Faul, MM	1
Cattaneo, E; Contini, A; Kazantsev, A; Leone, S; Moro, S; Mutti, C; Rigamonti, D; Sturlese, M	1
Adhikari, S; De, S; Devasagayam, TP; Menon, VP; Tilak-Jain, J	1
Chen, X; Liu, Z; Yu, L; Zhang, A; Zhen, X	1
Kawasaki, I; Kunitomo, J; Kuramoto, M; Ohishi, T; Ohishi, Y; Sakata, Y; Takeda, S; Tanaka, S; Terai, K; Yokomizo, T	1
DEICHMANN, WB; KITZMILLER, KV	1
PHATAK, NM; SAXEY, E	1
Du, J; Li, J; Liu, H; Liu, M; Xi, L; Yao, X	1
Ghaemmaghami, S; May, BC; Prusiner, SB; Renslo, AR	1
Allen, JG; Bourbeau, MP; Fotsch, C; Hong, FT; Lee, MR; Li, C; Skiles, GL; Subramanian, R; Surapaneni, S; Tadesse, S; Wang, X; Wohlhieter, GE; Yao, G; Yuan, CC; Zeng, Q; Zhou, Y; Zhu, X	1
Bourbeau, MP; Dominguez, C; Freeman, D; Hoffman, D; Huang, X; Hungate, R; Lee, MR; Li, C; Lofgren, J; Monenschein, H; Rider, JT; Tasker, AS; Tominey, E; Viswanadhan, VN; Wohlhieter, GE; Yamane, H; Yao, G; Zeng, Q; Zhang, S; Zhang, X	1
Arutyunyan, S; Nefzi, A	1
LAND, AH; SPRAGUE, JM; ZIEGLER, C	1
Arai, T; Eguchi, T; Fukasawa, K; Hasako, S; Haze, K; Hirai, H; Ichikawa, K; Iwasawa, Y; Kawanishi, N; Kobayashi, M; Kodera, T; Kotani, H; Machida, T; Nakatsuru, Y; Oki, H; Shimomura, T; Takahashi-Suziki, I; Taniguchi, E	1
Balasubramanian, T; John, J	1
Baraldi, PG; Borea, PA; Gessi, S; Merighi, S; Romagnoli, R; Tabrizi, MA	1
Anlauf, U; Buchstaller, HP	1
Griffioen, G; Lagoja, I; Pannecouque, C; Rojasdelaparra, VM; Van Aerschot, A; Wera, S	1
Baek, KJ; Hahn, HG; Kim, DS; Kim, SY; Kwon, NS; Nam, KD; Park, KC; Yun, HY	1
Kalanithi, M; Kodimunthiri, D; Rajarajan, M; Tharmaraj, P	1
Buchwald, SL; Henderson, JL; McGowan, MA	1
Chang, HH; Davis, A; Dietrich, J; Gokhale, V; Hulme, C; Medda, F; Meuillet, EJ; Smith, B	1
Powner, MW; Szostak, JW; Zheng, SL	1
Akhlaq, M; Bloomfield, GC; Bruce, I; Budd, E; Cox, B; Cuenoud, B; Finan, P; Gedeck, P; Hatto, J; Hayler, JF; Head, D; Keller, T; Kirman, L; Le Grand, D; Leblanc, C; McCarthy, C; O'Connor, D; Owen, C; Oza, MS; Pilgrim, G; Press, NE; Sviridenko, L; Whitehead, L	1
Abou-Gharbia, M; Annadurai, S; Canney, DJ; Dunman, PM; Eidem, T; Martinez, R	1
Endo, M; Fujii, Y; Matsumoto, K; Ohtake, H; Oka, Y; Sekiguchi, Y; Tamura, Y; Wakahara, S; Yabuuchi, T	1
Benet, LZ; Dalvie, DK; Elepano, M; Fife, KL; Freyman, Y; Gallardo-Godoy, A; Gever, JR; Giles, K; Huang, Y; Jacobson, MP; Li, Z; Prusiner, SB; Rao, S; Renslo, AR; Silber, BM	1
Angelucci, A; Botta, M; Brullo, C; Christopher, RS; Crespan, E; Delle Monache, S; Kissova, M; Maga, G; Mori, M; Musumeci, F; Radi, M; Sanità, P; Schenone, S; Tintori, C	1
Bryant, C; Dolghih, E; Elepano, M; Gallardo-Godoy, A; Gever, JR; Jacobson, MP; Li, Z; Prusiner, SB; Rao, S; Renslo, AR; Silber, BM; Widjaja, K	1
Cao, X; Gu, Y; Wang, W; Zhu, X	1
Cheng, CC; Davis, N; Duca, JS; Fischmann, TO; Huang, X; Parry, D; Reddy, PA; Richards, M; Seghezzi, W; Shipps, GW; Siddiqui, MA; Tadikonda, PK; Wiswell, D; Zhao, L	1
Chang, M; Hua, J; Huang, CS; Lam, PY; Lloyd, J; Pi, Z; Price, L; Rehfuss, R; Sutton, J; Wexler, RR; Wu, Q; Zheng, J	1
Karale, NN; Lawand, AS; More, PG; Nalawade, AM; Rajmane, SV; Ubale, VP	1
Berry, DB; Bhardwaj, S; DeArmond, SJ; Geva, M; Giles, K; Lu, D; Oehler, A; Prusiner, SB; Renslo, AR; Watts, JC	1
Cho, S; Costantino, G; Franzblau, SG; Pieroni, M; Wan, B	1
Chibale, K; De Kock, C; Mizrahi, V; Mjambili, F; Naran, K; Njoroge, M; Smith, PJ; Warner, D	1
Ghaemmaghami, S; Renslo, AR; Russo, M	1
Chang, CC; Chang, JM; Chuang, SH; Huang, JJ; Huang, LY; Jian, PS; Lai, CL; Lai, JY; Lam, K; Lau, JY; Lee, YS; Lin, HS; Lin, YH; Liu, CW; Yang, JY; Yang, SC	1
Gomez, RC; Hanke, T; Lamers, C; Schneider, G; Schubert-Zsilavecz, M; Werz, O	1
Brüggerhoff, A; Ihlefeld, K; Proschak, E; Stark, H; Vogt, D; Weber, J	1
Kannan, T; Makam, P	1
Burdette, D; Eismin, R; Kenttämaa, H; Urbanek, R; Wu, Y; Xiong, H; Zhang, M	1
Baell, JB; Chandrashekaran, IR; Debono, CO; Devine, SM; Leung, EW; Lim, SS; Mohanty, B; Mulcair, MD; Nissink, JW; Norton, RS; Scammells, PJ; Scanlon, MJ; Simpson, JS; Vazirani, M	1
Augustynowicz-Kopec, E; Bielenica, A; Boi, S; Drzewiecka, A; Filipowska, A; Filipowski, W; Giliberti, G; Koziol, AE; La Colla, P; Madeddu, S; Napiorkowska, A; Nowicka, G; Sanna, G; Stefanska, J; Struga, M; Szulczyk, D	1
Cox, N; Gomer, RH; Pilling, D	1
Berry, D; Bhardwaj, S; DeArmond, SJ; Giles, K; Oehler, A; Prusiner, SB	1
Arz, D; Caravatti, G; Fairhurst, RA; Fritsch, C; Furet, P; Gerspacher, M; Guthy, DA; Haasen, D; Imbach-Weese, P; Trappe, J; Wirth, J; Zoller, T	1
Berry, DB; Bhardwaj, S; Bryant, C; Condello, C; DeArmond, SJ; Elepano, M; Gallardo-Godoy, A; Giles, K; Guan, S; Hawley, RC; Oehler, A; Patel, S; Prusiner, SB; Renslo, AR; Silber, BM	1
Emery, FS; Ganesan, A; Honório, KM; Maltarollo, VG; Trossini, GH	1
Eickhoff, JA; Kobayashi, H; Zakarian, A	1
Bairagi, M; Das, D; Sikdar, P	1
Häfner, AK; Hofmann, B; M Kretschmer, SB; Rödl, CB; Stark, H; Steinhilber, D; Vogt, D; Woltersdorf, S	1
Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Szular, J; Wilkinson, SR	1
Alling, T; Bailey, MA; Bowman, J; Dalai, S; Early, JV; Hipskind, PA; Kesicki, EA; Kumar, N; Masquelin, T; Odingo, JO; Ovechkina, Y; Parish, T; Zuniga, ES	1
Deng, H; Gao, C; Lei, Q; Liu, Z; Peng, C; Ran, K; Shi, Y; Wang, N; Wei, W; Xiao, K; Xiong, L; You, X; Yu, L	1
Al-Radadi, NS; Attia, MS	1
Filipowska, A; Filipowski, W; Nowicka, G; Struga, M; Tkacz, E	1
Angioni, C; Geisslinger, G; Häfner, AK; Hofmann, B; Kaiser, A; Karas, M; Kretschmer, SB; Lillich, FF; Maucher, IV; Roos, J; Rühl, M; Schubert-Zsilavecz, M; Stark, H; Steinhilber, D; Vogt, D; Woltersdorf, S; Wurglics, M	1
Giles, K; Olson, SH; Prusiner, SB	1
Ha, S; Ham, SW; Kim, YH; Oh, J	1
Alpaslan, FN; Buyukbingol, E; Erdas, O; Konyar, D	1
Lin, C; Lin, X; Nong, W; Wang, L; Wei, J; Zhao, A	1
Abbasova, M; Alwasel, SH; Beydemir, Ş; Farzaliyev, V; Gulçin, İ; Huyut, Z; Safarova, L; Sujayev, A; Supuran, CT; Taslimi, P	1
Chen, JK; Chuang, H; Fu, PK; Hsu, MH; Huang, NC; Huang, SC; Huang, YP; Hung, YW; Jeng, KC; Li, JP; Yang, CY	1
Ha, S; Ham, SW; Jeong, J; Oh, J; Rhee, S	1
Bheemanaboina, RRY; Gao, WW; Gopala, L; Li, S; Zhang, GB; Zhou, CH	1
Khalifa, ME	1
Kantevari, S; Marvadi, SK; Sriram, D; Surineni, G; Yogeeswari, P	1
Abdel Gawad, NM; Abdel-Aziz, MM; Abo-Ashour, MF; Abou-Seri, SM; Elaasser, MM; Eldehna, WM; George, RF	1
Azzali, E; Costantino, G; Couto, I; Machado, D; Pieroni, M; Viveiros, M	1
Bacchus-Montabonel, MC	1
Kirmusaoglu, S	1
Bothwell, PJ; Fisher, SS; Hamaker, CG; Huffman, SE; Jones, MA; Platt, DC; Webb, MI; Yawson, GK	1
Amorim, CR; de Moraes, J; Duque, MD; Lopes, AFS; Mengarda, ACA; Pavani, TFA; Rando, DGG; Silva, MP	1
Mourad, AAE; Mourad, MAE	1
Jakopin, Ž	1
Gao, H; Long, J; Tang, Z; Wan, Y	1
Abdel-Rady, M; Abou-Salim, MA; Atalla, AA; Barakat, A; El-Adasy, AA; Elshaier, YAMM; Hassan, MIA; Hussein, AHM; Khames, AA	1
Farouk Elsadek, M; Fawzi Farahat, M; Mohamed Ahmed, B	1
Bader, CD; Diamanti, E; Fischer, M; Hirsch, AKH; Illarionov, B; Müller, R; Ropponen, HK; Rottmann, M; Witschel, M	1
Chen, J; Cheng, X; Gama-Brambila, RA; Münch, C; Tascher, G; Zhou, J	1
Ansari, MF; Li, S; Wang, J; Zhang, PL; Zhou, CH	1
Břehová, P; Česnek, M; Chaloupecká, E; Dračínský, M; Janeba, Z; Mertlíková-Kaiserová, H; Skácel, J; Soto-Velasquez, MP; Tloušťová, E; Watts, VJ	1
Amerhanova, S; Boga, C; Burilov, A; Chugunova, E; Gerasimova, T; Gilfanova, A; Islamov, D; Lyubina, A; Micheletti, G; Syakaev, V; Telese, D; Tulesinova, A; Usachev, K; Voloshina, A	1
Altaf, R; Aun Muhammad, S; Faheem, M; Ilyas, U; Nadeem, H; Naz, S; Qadir, MI; Uz Zaman, S	1
Khlebnicova, TS; Lakhvich, FA; Matous, AE; Piven, YA; Scherbakov, AM; Shchegolev, YY; Sorokin, DV; Yastrebova, MA; Zinovich, VG	1
de Andrade, VS; de Mattos, MC; Oliveira, DF; Pereira, FA; Souza, EA	1
Arsenijević, N; Gajović, N; Jevtić, VV; Jovanović, I; Jovičić Milić, SS; Jurišević, M; Kačániová, M; Klisurić, OR; Petrović, A; Petrović, BV; Petrović, ĐS; Radisavljević, SR; Radojević, ID; Raković, IR; Stojković, DL; Vukić, M; Vuković, NL	1
Huang, K; Jin, Y; Lin, J; Liu, J; Wang, S; Yuan, L	1
Fordham, JM; Piacentini, P; Santagostino, M	1
Bhat, MU; Ganie, MA; Raheem, S; Rizvi, MA; Shah, BA	1
Deng, M; Li, J; Liu, T; Long, X; Wang, C; Wang, P; Xu, G; Zhou, Y	1
Allegro, D; Barbier, P; Breuzard, G; DiMaio, A; Hedna, R; Kovacic, H; Peyrot, V; Robin, M; Tatoni, M	1

Reviews

8 review(s) available for thiazoles and 2-aminothiazole

Article	Year
Allosteric enhancers of A1 adenosine receptors: state of the art and new horizons for drug development. Current medicinal chemistry, 2010, Volume: 17, Issue:30 Topics: Allosteric Regulation; Humans; Receptor, Adenosine A1; Thiazoles; Thiophenes	2010
Successes and challenges in phenotype-based lead discovery for prion diseases. Journal of medicinal chemistry, 2014, Aug-28, Volume: 57, Issue:16 Topics: Animals; Brain; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Drug Discovery; Drug Evaluation, Preclinical; Humans; Mice; Prion Diseases; Structure-Activity Relationship; Thiazoles	2014
Recent developments of 2-aminothiazoles in medicinal chemistry. European journal of medicinal chemistry, 2016, Feb-15, Volume: 109 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Anticonvulsants; Antihypertensive Agents; Antineoplastic Agents; Drug Discovery; Humans; Hypoglycemic Agents; Neuroprotective Agents; Structure-Activity Relationship; Thiazoles	2016
Developing Therapeutics for PrP Prion Diseases. Cold Spring Harbor perspectives in medicine, 2017, Apr-03, Volume: 7, Issue:4 Topics: Animals; Disease Progression; High-Throughput Screening Assays; Humans; Mice; Molecular Targeted Therapy; Polyelectrolytes; Polymers; Prion Diseases; Prions; Protein Conformation; Thiazoles	2017
Recent Developments and Biological Activities of 2-Aminothiazole Derivatives. Acta chimica Slovenica, 2018, Volume: 65, Issue:1 Topics: Aldehydes; Amines; Anti-Bacterial Agents; Chromans; Molecular Structure; Oxidation-Reduction; Solvents; Structure-Activity Relationship; Thiazoles; Thiourea	2018
2-aminothiazoles in drug discovery: Privileged structures or toxicophores? Chemico-biological interactions, 2020, Oct-01, Volume: 330 Topics: Animals; Drug Discovery; Humans; Structure-Activity Relationship; Thiazoles	2020
2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents. European journal of medicinal chemistry, 2021, Jan-15, Volume: 210 Topics: Animals; Antineoplastic Agents; Drug Design; Drug Discovery; Humans; Neoplasms; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles; Tubulin Modulators	2021
An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities. Molecules (Basel, Switzerland), 2021, Mar-07, Volume: 26, Issue:5 Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Antioxidants; Humans; Structure-Activity Relationship; Thiazoles	2021

Other Studies

111 other study(ies) available for thiazoles and 2-aminothiazole

Article	Year
Derivatization-liquid chromatographic assay of chloroacetaldehyde in biological samples. Journal of chromatography, 1990, Oct-05, Volume: 518, Issue:2 Topics: Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Female; Microsomes, Liver; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Thiazoles	1990
Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. The Journal of biological chemistry, 1994, Oct-28, Volume: 269, Issue:43 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Endothelium, Vascular; Enzyme Induction; Humans; Isoenzymes; Isothiuronium; Kinetics; Mice; Models, Chemical; Neurons; Nitric Oxide Synthase; Species Specificity; Structure-Activity Relationship; Thiazoles; Thiourea	1994
Introduction of novel substrate oxidation into cytochrome c peroxidase by cavity complementation: oxidation of 2-aminothiazole and covalent modification of the enzyme. Biochemistry, 1997, Sep-30, Volume: 36, Issue:39 Topics: Binding Sites; Crystallography, X-Ray; Cytochrome-c Peroxidase; Electron Spin Resonance Spectroscopy; Escherichia coli; Models, Molecular; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oxidation-Reduction; Peptide Mapping; Protein Conformation; Protein Engineering; Spectroscopy, Fourier Transform Infrared; Thiazoles	1997
Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex. Journal of virology, 1998, Volume: 72, Issue:9 Topics: Amino Acid Sequence; Animals; Antiviral Agents; Asparagine; Base Composition; Cell Line; Chlorocebus aethiops; DNA Helicases; DNA Primase; DNA Replication; Drug Resistance, Microbial; Enzyme Inhibitors; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Lysine; Molecular Sequence Data; Mutagenesis; Sequence Homology, Amino Acid; Spodoptera; Thiazoles; Vero Cells; Viral Proteins; Virus Replication	1998
Streamlined synthesis of substituted 2-aminothiazoles using tandem precipitative and polymer-assisted reactions. Biotechnology and bioengineering, 2000,Winter, Volume: 71, Issue:1 Topics: Antiviral Agents; Indicators and Reagents; Models, Molecular; Molecular Structure; Polymers; Resins, Plant; Thiazoles	2000
Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors. Bioorganic & medicinal chemistry letters, 2001, Apr-09, Volume: 11, Issue:7 Topics: Amidines; Drug Design; Drug Evaluation, Preclinical; Plasminogen Activators; Structure-Activity Relationship; Thiazoles; Thiophenes; Urokinase-Type Plasminogen Activator	2001
Tetrakis(2-amino-5-methyl-1,3,4-thiadiazole-N3)chlorocopper(II) chloride monohydrate and tetrakis(2-amino-5-ethyl-1,3,4-thiadiazole-N3)chlorocopper(II) chloride. Acta crystallographica. Section C, Crystal structure communications, 2001, Volume: 57, Issue:Pt 9 Topics: Copper; Crystallography, X-Ray; Hydrogen Bonding; Molecular Conformation; Molecular Structure; Organometallic Compounds; Thiazoles	2001
2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors. Bioorganic & medicinal chemistry letters, 2002, Jun-17, Volume: 12, Issue:12 Topics: Allosteric Regulation; Humans; Purinergic P1 Receptor Agonists; Structure-Activity Relationship; Thiazoles	2002
Designing focused libraries using MoSELECT. Journal of molecular graphics & modelling, 2002, Volume: 20, Issue:6 Topics: Algorithms; Amides; Combinatorial Chemistry Techniques; DNA Helicases; Drug Design; Molecular Structure; Peptide Library; Quantitative Structure-Activity Relationship; Software; Thiazoles	2002
Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2. Angewandte Chemie (International ed. in English), 2002, Dec-16, Volume: 41, Issue:24 Topics: Combinatorial Chemistry Techniques; Enzyme Inhibitors; Inhibitory Concentration 50; Molecular Structure; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Substrate Specificity; Thiazoles; Vascular Endothelial Growth Factor Receptor-2	2002
Determination of Cu, Ni, and Zn in fuel ethanol by FAAS after enrichment in column packed with 2-aminothiazole-modified silica gel. Analytical and bioanalytical chemistry, 2003, Volume: 375, Issue:4 Topics: Automobiles; Chelating Agents; Chromatography; Copper; Energy-Generating Resources; Ethanol; Metals, Heavy; Nickel; Silica Gel; Silicon Dioxide; Thiazoles; Zinc	2003
Activation of peroxidase-catalyzed oxidation of aromatic amines with 2-aminothiazole and melamine. Biochemistry. Biokhimiia, 2003, Volume: 68, Issue:1 Topics: Amines; Catalysis; Hydrogen-Ion Concentration; Kinetics; Oxidation-Reduction; Peroxidase; Structure-Activity Relationship; Thiazoles; Triazines	2003
2-aminothiazole and 2-aminothiazolinone derivatives. Acta crystallographica. Section C, Crystal structure communications, 2003, Volume: 59, Issue:Pt 9 Topics: Crystallography, X-Ray; Hydrogen Bonding; Molecular Structure; Thiazoles	2003
[Synthetic antitubercular agents. Note 3. Derivatives of phenylthiourea and of N-phenyl-2-aminothiazole]. Il Farmaco; edizione scientifica, 1960, Volume: 15 Topics: Antithyroid Agents; Antitubercular Agents; Phenylthiourea; Thiazoles; Thiourea	1960
[Studies on the synthesis of the 2-aminothiazole derivatives. III. King's reaction in the basic medium]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1961, Volume: 81 Topics: Thiazoles	1961
[Studies on the synthesis of the 2-aminothiazole derivatives. IV. Reaction of the 1,1'-dithiodiformamidine hydrohalide with the ketones]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1961, Volume: 81 Topics: Ketones; Thiazoles	1961
[Studies on synthesis of the 2-aminothiazole derivatives. I]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1961, Volume: 81 Topics: Thiazoles	1961
[Studies on the synthesis of the 2-aminothiazole derivatives. II. On the bromination of the alkyl ethyl ketones]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1961, Volume: 81 Topics: Halogenation; Ketones; Thiazoles	1961
Structure-activity relationships of 2-aminothiazole derivatives as inducible nitric oxide synthase inhibitor. Chemical & pharmaceutical bulletin, 2004, Volume: 52, Issue:5 Topics: Animals; Cell Line; Enzyme Inhibitors; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazoles	2004
Determination of cadmium in river water samples by flame AAS after on-line preconcentration in mini-column packed with 2-aminothiazole-modified silica gel. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2004, Volume: 20, Issue:7 Topics: Cadmium; Calibration; Hydrochloric Acid; Hydrogen-Ion Concentration; Ions; Models, Chemical; Silica Gel; Silicon Dioxide; Spectrophotometry; Spectrophotometry, Atomic; Spectrophotometry, Infrared; Thiazoles; Time Factors; Water	2004
[Changes in chlorhydric and mucinous secretions induced by synthetic antithyroid agents (4-methyl-2-thiouracil=6n propyl-2-thiouracile=4-methyl-2-aminothiazole=5,5-diethyl-2-thiobarbituric acid)]. Giornale di clinica medica, 1949, Volume: 30, Issue:9 Topics: Antithyroid Agents; Barbital; Methylthiouracil; Thiazoles; Thiobarbiturates; Thiopental; Thiourea; Thyroid Gland	1949
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2004, Nov-15, Volume: 14, Issue:22 Topics: Alzheimer Disease; Amides; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Molecular Structure; Nerve Tissue Proteins; Structure-Activity Relationship; Thiazoles	2004
Isolation and characterization of herpes simplex virus type 1 resistant to aminothiazolylphenyl-based inhibitors of the viral helicase-primase. Antiviral research, 2004, Volume: 64, Issue:3 Topics: Animals; Antiviral Agents; Disease Models, Animal; DNA Helicases; DNA Primase; Drug Resistance, Viral; Enzyme Inhibitors; Herpesvirus 1, Human; Mice; Mice, Inbred BALB C; Mutagenesis; Thiazoles; Viral Proteins	2004
Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers. Bioorganic & medicinal chemistry, 2005, Mar-15, Volume: 13, Issue:6 Topics: Allosteric Regulation; Amides; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Humans; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Structure-Activity Relationship; Thiazoles	2005
[The design and synthesis of 2-aminothiazole derivatives and their inhibitory activity on apoptosis]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:8 Topics: Animals; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Hydrogen Peroxide; Molecular Structure; Neuroprotective Agents; PC12 Cells; Quantitative Structure-Activity Relationship; Rats; Thiazoles	2006
A solid paraffin-based carbon paste electrode modified with 2-aminothiazole organofunctionalized silica for differential pulse adsorptive stripping analysis of nickel in ethanol fuel. Analytica chimica acta, 2007, Feb-19, Volume: 584, Issue:2 Topics: Adsorption; Carbon; Electrodes; Energy-Generating Resources; Ethanol; Nickel; Oximes; Paraffin; Silicon Dioxide; Thiazoles	2007
New methods for the synthesis of 2-aminothiazolones. The Journal of organic chemistry, 2008, Mar-07, Volume: 73, Issue:5 Topics: Cyclization; Magnetic Resonance Spectroscopy; Thiazoles	2008
SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease. Bioorganic & medicinal chemistry, 2008, May-15, Volume: 16, Issue:10 Topics: Gene Expression Regulation; Gene Library; Gene Silencing; Huntington Disease; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Repressor Proteins; Reproducibility of Results; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Transcription, Genetic	2008
Antioxidant activity of an aminothiazole compound: possible mechanisms. Chemico-biological interactions, 2008, Jun-17, Volume: 173, Issue:3 Topics: Animals; Antioxidants; DNA; DNA Damage; Female; Free Radical Scavengers; Lipid Peroxidation; Mitochondria, Liver; Molecular Structure; Oxidation-Reduction; Proteins; Rats; Rats, Wistar; Thiazoles; Triazoles	2008
Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14 Topics: Animals; Antiparkinson Agents; Aporphines; Humans; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D1; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Thiazoles	2008
Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells. Organic & biomolecular chemistry, 2008, Aug-07, Volume: 6, Issue:15 Topics: Animals; Antineoplastic Agents; Benzofurans; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Pancreatic Neoplasms; Receptors, Leukotriene B4; Thiazoles	2008
The physiological response of experimental animals following absorption of 2-aminothiazole. The Journal of industrial hygiene and toxicology, 1948, Volume: 30, Issue:2 Topics: Animals; Animals, Laboratory; Thiazoles	1948
Use of oxygen consumption method for measuring antithyroid activity of n-propylthiouracil, thiouracil and 2-aminothiazole in rats. Federation proceedings, 1948, Volume: 7, Issue:1 Pt 1 Topics: Animals; Oxygen Consumption; Propylthiouracil; Rats; Thiazoles; Thiouracil; Thiourea	1948
Validated quantitative structure-activity relationship analysis of a series of 2-aminothiazole based p56(Lck) inhibitors. Analytica chimica acta, 2009, Jan-05, Volume: 631, Issue:1 Topics: Algorithms; Artificial Intelligence; Enzyme Inhibitors; Genetics; Linear Models; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Quantitative Structure-Activity Relationship; Reproducibility of Results; Thiazoles	2009
Discovery of 2-aminothiazoles as potent antiprion compounds. Journal of virology, 2010, Volume: 84, Issue:7 Topics: Animals; Cell Line, Tumor; Drug Discovery; Enzyme-Linked Immunosorbent Assay; High-Throughput Screening Assays; Mice; Prion Diseases; Prions; PrPSc Proteins; Structure-Activity Relationship; Thiazoles	2010
Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening. Chemical research in toxicology, 2010, Mar-15, Volume: 23, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Epoxy Compounds; Glutathione; Humans; Microsomes, Liver; Models, Biological; Molecular Structure; Proto-Oncogene Proteins c-akt; Rats; Thiazoles	2010
2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics. Bioorganic & medicinal chemistry letters, 2010, Mar-01, Volume: 20, Issue:5 Topics: Animals; Antineoplastic Agents; Catalytic Domain; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 2; Isoquinolines; Mice; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Structure-Activity Relationship; Thiadiazoles; Thiazoles	2010
Synthesis of chiral polyaminothiazoles. Journal of combinatorial chemistry, 2010, May-10, Volume: 12, Issue:3 Topics: Biological Products; Models, Chemical; Peptides; Polymers; Resins, Synthetic; Stereoisomerism; Thiazoles	2010
t-Aminoalkyl derivatives of 2-aminothiazole. Journal of the American Chemical Society, 1947, Volume: 69, Issue:1 Topics: Thiazoles	1947
Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo. Cell cycle (Georgetown, Tex.), 2010, Apr-15, Volume: 9, Issue:8 Topics: Animals; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; E2F Transcription Factors; G1 Phase; Humans; Male; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Nude; Retinoblastoma Protein; RNA Interference; RNA, Small Interfering; Thiazoles; Transplantation, Heterologous	2010
Z and E isomers of butenedioic acid with 2-amino-1,3-thiazole: 2-amino-1,3-thiazolium hydrogen maleate and 2-amino-1,3-thiazolium hydrogen fumarate. Acta crystallographica. Section C, Crystal structure communications, 2010, Volume: 66, Issue:Pt 8 Topics: Butyric Acid; Crystallography, X-Ray; Fumarates; Hydrogen Bonding; Isomerism; Maleates; Models, Molecular; Molecular Structure; Thiazoles	2010
Parallel solution-phase synthesis of a 2-aminothiazole library including fully automated work-up. Combinatorial chemistry & high throughput screening, 2011, Volume: 14, Issue:2 Topics: Combinatorial Chemistry Techniques; Small Molecule Libraries; Thiazoles	2011
Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Aug-17, Volume: 43, Issue:5 Topics: Alzheimer Disease; Cell Line; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Biological; Neurons; tau Proteins; Thiazoles	2011
A derivative of 2-aminothiazole inhibits melanogenesis in B16 mouse melanoma cells via glycogen synthase kinase 3β phosphorylation. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:8 Topics: alpha-MSH; Animals; Dose-Response Relationship, Drug; Down-Regulation; Glycogen Synthase Kinases; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Phosphorylation; Signal Transduction; Thiazoles; Wnt Proteins	2011
Synthesis, characterization and biological activity of some new VO(IV), Co(II), Ni(II), Cu(II) and Zn(II) complexes of chromone based NNO Schiff base derived from 2-aminothiazole. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2011, Volume: 82, Issue:1 Topics: Anti-Bacterial Agents; Aspergillus niger; Bacillus subtilis; Candida albicans; Copper; Electron Spin Resonance Spectroscopy; Escherichia coli; Ligands; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Nickel; Oxides; Pseudomonas aeruginosa; Schiff Bases; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Staphylococcus aureus; Thiazoles; Vanadium; Zinc	2011
Palladium-catalyzed N-arylation of 2-aminothiazoles. Organic letters, 2012, Mar-16, Volume: 14, Issue:6 Topics: Catalysis; Hydrocarbons, Brominated; Mesylates; Molecular Structure; Palladium; Thiazoles	2012
Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells. Bioorganic & medicinal chemistry letters, 2012, May-15, Volume: 22, Issue:10 Topics: Cell Line; Dinoprostone; Humans; Inhibitory Concentration 50; Thiazoles	2012
Multicomponent assembly of proposed DNA precursors in water. Journal of the American Chemical Society, 2012, Aug-22, Volume: 134, Issue:33 Topics: Acetaldehyde; Cyanamide; Deoxyribonucleotides; DNA; Oxazoles; Thiazoles; Thiosugars; Water	2012
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17 Topics: Animals; Catalytic Domain; Female; Humans; Mice; Models, Molecular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase Inhibitors; Rats; Signal Transduction; Thiazoles	2012
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA. Bioorganic & medicinal chemistry letters, 2012, Dec-15, Volume: 22, Issue:24 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Design; Escherichia coli; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles	2012
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors. Bioorganic & medicinal chemistry letters, 2012, Dec-15, Volume: 22, Issue:24 Topics: Animals; Class Ib Phosphatidylinositol 3-Kinase; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; High-Throughput Screening Assays; Macrophages; Mice; Models, Molecular; Molecular Structure; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles	2012
Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharmaceutical research, 2013, Volume: 30, Issue:4 Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Brain; Cell Line; Cytochrome P-450 Enzyme System; Humans; Mice; Microsomes, Liver; Prion Diseases; Protein Isoforms; PrPSc Proteins; Solubility; Thiazoles	2013
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. ChemMedChem, 2013, Volume: 8, Issue:3 Topics: Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; Binding, Competitive; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Humans; Indoles; Kinetics; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-pim-1; Pyrroles; Recombinant Proteins; Structure-Activity Relationship; Thiazoles	2013
2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease. ChemMedChem, 2013, Volume: 8, Issue:5 Topics: Administration, Oral; Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Mice; Models, Molecular; Molecular Structure; Pregnancy Proteins; Prion Diseases; Quantum Theory; Structure-Activity Relationship; Thiazoles	2013
Molecular dynamic simulations give insight into the mechanism of binding between 2-aminothiazole inhibitors and CDK5. Journal of molecular modeling, 2013, Volume: 19, Issue:6 Topics: Cyclin-Dependent Kinase 5; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Thiazoles	2013
Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. Bioorganic & medicinal chemistry letters, 2013, May-01, Volume: 23, Issue:9 Topics: Amides; Binding Sites; Checkpoint Kinase 1; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Drug Design; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Structure-Activity Relationship; Thiazoles	2013
2-Aminothiazole based P2Y(1) antagonists as novel antiplatelet agents. Bioorganic & medicinal chemistry letters, 2013, Jul-15, Volume: 23, Issue:14 Topics: Aminopyridines; Animals; Blood Platelets; Half-Life; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y1; Structure-Activity Relationship; Thiazoles	2013
A 4-(o-chlorophenyl)-2-aminothiazole: microwave assisted synthesis, spectral, thermal, XRD and biological studies. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013, Volume: 115 Topics: Animals; Anthelmintics; Anti-Infective Agents; Escherichia coli; Fungi; Kinetics; Lymnaea; Microbial Sensitivity Tests; Microwaves; Mollusca; Plant Roots; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Temperature; Thiazoles; Tylenchoidea; X-Ray Diffraction	2013
Drug resistance confounding prion therapeutics. Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-29, Volume: 110, Issue:44 Topics: Animals; Brain; Cell Line; DNA Primers; Drug Discovery; Drug Resistance; Female; Humans; Immunoblotting; Luminescent Measurements; Mice; Neurodegenerative Diseases; Prions; Thiazoles	2013
Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents. European journal of medicinal chemistry, 2014, Jan-24, Volume: 72 Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazoles; Tuberculosis; Vero Cells	2014
Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents. Bioorganic & medicinal chemistry letters, 2014, Jan-15, Volume: 24, Issue:2 Topics: Animals; Anti-Bacterial Agents; Antimalarials; CHO Cells; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Mycobacterium tuberculosis; Plasmodium falciparum; Thiazoles	2014
Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties. Journal of medicinal chemistry, 2014, May-22, Volume: 57, Issue:10 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytoskeletal Proteins; Drug Discovery; Female; Humans; Male; Mice; Mice, Inbred BALB C; NIMA-Related Kinases; Nuclear Proteins; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Thiazoles; Xenograft Model Antitumor Assays	2014
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition. Bioorganic & medicinal chemistry letters, 2014, Aug-15, Volume: 24, Issue:16 Topics: Arachidonate 5-Lipoxygenase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Models, Molecular; Molecular Structure; PPAR alpha; PPAR gamma; Prostaglandin-E Synthases; Pyrimidines; Structure-Activity Relationship; Thiazoles	2014
Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19 Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Design; Humans; Intracellular Signaling Peptides and Proteins; Molecular Conformation; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles	2014
2-Aminothiazole derivatives as antimycobacterial agents: Synthesis, characterization, in vitro and in silico studies. European journal of medicinal chemistry, 2014, Nov-24, Volume: 87 Topics: Antitubercular Agents; Computer Simulation; Crystallography, X-Ray; In Vitro Techniques; Magnetic Resonance Spectroscopy; Models, Molecular; Spectrometry, Mass, Electrospray Ionization; Thiazoles	2014
Identification of 2-aminothiazolobenzazepine metabolites in human, rat, dog, and monkey microsomes by ion-molecule reactions in linear quadrupole ion trap mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:3 Topics: Animals; Chromatography, Liquid; Dogs; Haplorhini; Humans; Ions; Macaca fascicularis; Male; Mass Spectrometry; Microsomes, Liver; Pyridines; Rats; Rats, Sprague-Dawley; Thiazoles	2015
Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold. Journal of medicinal chemistry, 2015, Feb-12, Volume: 58, Issue:3 Topics: Drug Discovery; High-Throughput Screening Assays; Magnetic Resonance Spectroscopy; Molecular Structure; Surface Plasmon Resonance; Thiazoles	2015
Antimicrobial and anti-biofilm activity of thiourea derivatives incorporating a 2-aminothiazole scaffold. Chemical & pharmaceutical bulletin, 2015, Volume: 63, Issue:3 Topics: Animals; Anti-Infective Agents; Biofilms; Cattle; Chlorocebus aethiops; Cricetinae; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Thiazoles; Thiourea; Vero Cells	2015
DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice. Proceedings of the National Academy of Sciences of the United States of America, 2015, Jul-07, Volume: 112, Issue:27 Topics: Animals; Blotting, Western; C-Reactive Protein; Cell Adhesion Molecules; Cells, Cultured; HEK293 Cells; Humans; Immunity, Innate; Interleukin-10; Lectins, C-Type; Lung; Macrophages; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Neutrophils; Protein Binding; Pulmonary Fibrosis; Receptors, Cell Surface; Receptors, IgG; Serum Amyloid P-Component; Thiazoles	2015
Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice. The Journal of infectious diseases, 2015, Jul-15, Volume: 212 Suppl 1 Topics: Animals; Brain; Cell Line; Deer; Drug Resistance; Female; Kaplan-Meier Estimate; Mice; Mice, Transgenic; Prions; Rabbits; Scrapie; Sheep; Thiazoles; Wasting Disease, Chronic	2015
Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors. Bioorganic & medicinal chemistry letters, 2015, Sep-01, Volume: 25, Issue:17 Topics: Animals; Class I Phosphatidylinositol 3-Kinases; Humans; Models, Molecular; Molecular Dynamics Simulation; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Thiazoles; Urea	2015
Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. The Journal of pharmacology and experimental therapeutics, 2015, Volume: 355, Issue:1 Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Humans; Mice; PrPSc Proteins; Scrapie; Species Specificity; Survival Analysis; Survival Rate; Thiazoles; Transgenes; Treatment Outcome	2015
Hologram quantitative structure-activity relationship and comparative molecular interaction field analysis of aminothiazole and thiazolesulfonamide as reversible LSD1 inhibitors. Future medicinal chemistry, 2015, Volume: 7, Issue:11 Topics: Drug Discovery; Enzyme Inhibitors; Histone Demethylases; Humans; Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Sulfonamides; Thiazoles	2015
Synthesis of 2-Aminoazoles from Thioesters via α-Heterosubstituted Ketones by Copper-Mediated Cross-Coupling. The Journal of organic chemistry, 2015, Oct-16, Volume: 80, Issue:20 Topics: Azoles; Copper; Esters; Imidazoles; Ketones; Molecular Structure; Oxazoles; Sulfhydryl Compounds; Thiazoles	2015
Development of novel aminothiazole-comprising 5-LO inhibitors. Future medicinal chemistry, 2016, Volume: 8, Issue:2 Topics: Arachidonate 5-Lipoxygenase; Cell Survival; Cells, Cultured; Drug Design; Humans; Leukocytes, Mononuclear; Lipoxygenase Inhibitors; Structure-Activity Relationship; Thiazoles	2016
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds. European journal of medicinal chemistry, 2016, Jul-19, Volume: 117 Topics: Amides; Antiprotozoal Agents; Cell Line; Chagas Disease; Humans; Leishmania; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma	2016
Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents. PloS one, 2016, Volume: 11, Issue:5 Topics: Animals; Antitubercular Agents; Iron Chelating Agents; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazoles; Vero Cells	2016
Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents. Bioorganic & medicinal chemistry letters, 2016, 08-01, Volume: 26, Issue:15 Topics: Animals; Anti-Bacterial Agents; Chlorocebus aethiops; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitrofurans; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Tuberculosis; Vero Cells	2016
Progress of pancreatitis disease biomarker alpha amylase enzyme by new nano optical sensor. Biosensors & bioelectronics, 2016, Dec-15, Volume: 86 Topics: alpha-Amylases; Biomarkers; Disease Progression; Early Diagnosis; Equipment Design; Equipment Failure Analysis; Humans; Luminescent Measurements; Male; Middle Aged; Nanoparticles; Nanotechnology; Optical Devices; Pancreatitis; Platinum; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Transducers; Young Adult	2016
Statistical Analysis of the Impact of Molecular Descriptors on Cytotoxicity of Thiourea Derivatives Incorporating 2-Aminothiazole Scaffold. Chemical & pharmaceutical bulletin, 2016, Volume: 64, Issue:8 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; L-Lactate Dehydrogenase; Models, Statistical; Molecular Structure; Structure-Activity Relationship; Thiazoles; Thiourea	2016
Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles. Biochemical pharmacology, 2017, Jan-01, Volume: 123 Topics: Cells, Cultured; Humans; Lipoxygenase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles	2017
Determination of the binding site of 2-aminothiazole derivative with importin β1 by UV-crosslinking experiment. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, Aug-15, Volume: 1060 Topics: Antineoplastic Agents; beta Karyopherins; Binding Sites; Drug Discovery; Molecular Docking Simulation; Tandem Mass Spectrometry; Thiazoles; Ultraviolet Rays	2017
An application of CIFAP for predicting the binding affinity of Chk1 inhibitors derived from 2-aminothiazole-4-carboxamide. Journal of molecular recognition : JMR, 2017, Volume: 30, Issue:11 Topics: Checkpoint Kinase 1; Humans; Imaging, Three-Dimensional; Inhibitory Concentration 50; Least-Squares Analysis; Models, Molecular; Protein Kinase Inhibitors; Support Vector Machine; Thiazoles	2017
Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorganic & medicinal chemistry letters, 2017, 09-15, Volume: 27, Issue:18 Topics: Amides; Blood Coagulation; Cinnamates; Dose-Response Relationship, Drug; Hemostatics; Humans; Molecular Structure; Partial Thromboplastin Time; Platelet Aggregation Inhibitors; Prothrombin Time; Structure-Activity Relationship; Thiazoles; Thrombin Time	2017
Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2017, Volume: 32, Issue:1 Topics: Acetylcholinesterase; Benzothiazoles; Benzoxazoles; Butyrylcholinesterase; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Structure-Activity Relationship; Thiazoles	2017
Evaluation of LPS-Induced Acute Lung Injury Attenuation in Rats by Aminothiazole-Paeonol Derivatives. Molecules (Basel, Switzerland), 2017, Sep-25, Volume: 22, Issue:10 Topics: Acetophenones; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Interleukin-6; Lipopolysaccharides; Male; Neutrophil Infiltration; Rats; Thiazoles	2017
A Small Organic Molecule Blocks EGFR Transport into the Nucleus by the Nonclassical Pathway Resulting in Repression of Cancer Invasion. Chembiochem : a European journal of chemical biology, 2018, 01-18, Volume: 19, Issue:2 Topics: beta Karyopherins; Cell Line, Tumor; Cell Nucleus; ErbB Receptors; Humans; Lung Neoplasms; Molecular Structure; Small Molecule Libraries; Thiazoles	2018
Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. European journal of medicinal chemistry, 2018, Feb-25, Volume: 146 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Berberine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Bacterial; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles	2018
Dibenzofuran, dibenzothiophene and N-methyl carbazole tethered 2-aminothiazoles and their cinnamamides as potent inhibitors of Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters, 2018, 05-15, Volume: 28, Issue:9 Topics: Anti-Bacterial Agents; Benzofurans; Carbazoles; Cell Survival; Cinnamates; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazoles; Thiophenes	2018
Synthesis and biological evaluation of 2-aminothiazole-thiazolidinone conjugates as potential antitubercular agents. Future medicinal chemistry, 2018, 06-01, Volume: 10, Issue:12 Topics: Antitubercular Agents; Cell Line; Drug Design; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazoles; Thiazolidines; Tuberculosis	2018
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics. Future microbiology, 2018, Volume: 13 Topics: Adenosine Triphosphate; Antitubercular Agents; Biological Transport; Humans; Macrophages; Membrane Potentials; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Thiazoles; Tuberculosis	2018
Role of sulfur in proton-induced collisions of RNA prebiotic precursors. Physical chemistry chemical physics : PCCP, 2019, Jan-21, Volume: 21, Issue:3 Topics: Chemistry, Physical; Evolution, Molecular; Models, Chemical; Physical Phenomena; Protons; RNA Precursors; Thermodynamics; Thiazoles	2019
Improved β-Lactam Susceptibility Against ica-Dependent Biofilm-Embedded Staphylococcus aureus by 2-Aminothiazole. Clinical laboratory, 2020, Jan-01, Volume: 66, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactams; Biofilms; Drug Resistance, Bacterial; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Staphylococcal Infections; Thiazoles	2020
Ruthenium(iii) complexes containing thiazole-based ligands that modulate amyloid-β aggregation. Metallomics : integrated biometal science, 2020, 04-01, Volume: 12, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Coordination Complexes; Crystallography, X-Ray; Humans; Ligands; Microscopy, Electron, Transmission; Peptide Fragments; Protein Aggregates; Rats; Ruthenium; Structure-Activity Relationship; Thiazoles	2020
Schiff bases of 4-Phenyl-2-Aminothiazoles as hits to new antischistosomals: Synthesis, in vitro, in vivo and in silico studies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Jul-01, Volume: 150 Topics: Animals; Anthelmintics; Computer Simulation; Enzymes; Female; Helminth Proteins; Male; Mice; Molecular Docking Simulation; Schiff Bases; Schistosoma mansoni; Schistosomiasis mansoni; Thiazoles	2020
Enhancing insulin sensitivity by dual PPARγ partial agonist, β-catenin inhibitor: Design, synthesis of new αphthalimido-o-toluoyl2-aminothiazole hybrids. Life sciences, 2020, Oct-15, Volume: 259 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adiponectin; Animals; beta Catenin; Cell Differentiation; Diabetes Mellitus, Type 2; Gene Expression; Glucose; Insulin; Insulin Resistance; Mice; Molecular Docking Simulation; Phthalimides; PPAR gamma; Rosiglitazone; Thiazoles; Thiazolidinediones	2020
Multifunctional Isosteric Pyridine Analogs-Based 2-Aminothiazole: Design, Synthesis, and Potential Phosphodiesterase-5 Inhibitory Activity. Molecules (Basel, Switzerland), 2021, Feb-09, Volume: 26, Issue:4 Topics: Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Humans; Phosphodiesterase 5 Inhibitors; Pyridines; Structure-Activity Relationship; Thiazoles	2021
Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity. ChemMedChem, 2021, 07-06, Volume: 16, Issue:13 Topics: Antimalarials; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Solutions; Structure-Activity Relationship; Thiazoles	2021
A PROTAC targets splicing factor 3B1. Cell chemical biology, 2021, 11-18, Volume: 28, Issue:11 Topics: Animals; Apoptosis; Cell Line, Tumor; Drosophila melanogaster; Humans; Phosphoproteins; Proteolysis; RNA Splicing; RNA Splicing Factors; Thiazoles	2021
Molecular design and preparation of 2-aminothiazole sulfanilamide oximes as membrane active antibacterial agents for drug resistant Acinetobacter baumannii. Bioorganic chemistry, 2021, Volume: 113 Topics: Acinetobacter baumannii; Animals; Anti-Bacterial Agents; Biofilms; Cell Line; Cell Survival; Drug Design; Drug Resistance, Multiple, Bacterial; Erythrocytes; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Humans; Microbial Sensitivity Tests; Molecular Conformation; Oxidative Stress; Oximes; Structure-Activity Relationship; Sulfanilamide; Thiazoles	2021
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases. European journal of medicinal chemistry, 2021, Oct-15, Volume: 222 Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Anti-Bacterial Agents; Bacillus anthracis; Bordetella pertussis; Cell Line; Dose-Response Relationship, Drug; Humans; Mice; Microbial Sensitivity Tests; Molecular Structure; Neuralgia; Organophosphonates; Structure-Activity Relationship; Thiazoles	2021
Novel Hybrid Compounds Containing Benzofuroxan and Aminothiazole Scaffolds: Synthesis and Evaluation of Their Anticancer Activity. International journal of molecular sciences, 2021, Jul-13, Volume: 22, Issue:14 Topics: Antineoplastic Agents; Apoptosis; Benzoxazoles; Cell Proliferation; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Molecular Structure; Structure-Activity Relationship; Thiazoles; Uterine Cervical Neoplasms	2021
Design, synthesis and biological evaluations of 2-aminothiazole scaffold containing amino acid moieties as anti-cancer agents. Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:4(Suppleme Topics: Amino Acids; Animals; Antineoplastic Agents; Artemia; Colorectal Neoplasms; Drug Design; HCT116 Cells; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Protein Conformation; Thiazoles	2021
Effective synthesis of novel dihydrobenzisoxazoles bearing the 2-aminothiazole moiety and evaluation of the antiproliferative activity of their acylated derivatives. Organic & biomolecular chemistry, 2021, 12-08, Volume: 19, Issue:47 Topics: Thiazoles	2021
2-Aminoselenazoles and 2-aminothiazoles: One-pot synthesis and control of the fungus Colletotrichum lindemuthianum in common beans. Pest management science, 2022, Volume: 78, Issue:4 Topics: Colletotrichum; Phaseolus; Plant Diseases; Thiazoles	2022
Synthesis, characterization, DNA interactions and biological activity of new palladium(II) complexes with some derivatives of 2-aminothiazoles. Journal of inorganic biochemistry, 2022, Volume: 233 Topics: Antineoplastic Agents; Coordination Complexes; DNA; Guanosine Monophosphate; Palladium; Serum Albumin, Bovine; Thiazoles	2022
Cascade Reaction of Tertiary Enaminones, KSCN, and Anilines: Temperature-Controlled Synthesis of 2-Aminothiazoles and 2-Iminothiazoline. The Journal of organic chemistry, 2022, 07-15, Volume: 87, Issue:14 Topics: Aniline Compounds; Temperature; Thiazoles; Thiocyanates	2022
Pd-Catalyzed Ring-Opening/Arylation/Cyclization of 2-Aminothiazole Derivatives Provides Modular Access to Isocytosine Analogues. The Journal of organic chemistry, 2022, 10-07, Volume: 87, Issue:19 Topics: Cyclization; Cytosine; Kinetics; Palladium; Thiazoles	2022
Photoredox-Promoted Selective Synthesis of C-5 Thiolated 2-Aminothiazoles from Terminal Alkynes. Organic letters, 2022, Oct-28, Volume: 24, Issue:42 Topics: Alkynes; Electrons; Thiazoles	2022
Design, Synthesis, and Biological Evaluation of 2-Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors. ChemMedChem, 2023, 04-03, Volume: 18, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Drug Design; Drug Screening Assays, Antitumor; Mice; Molecular Structure; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles	2023
2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma. International journal of molecular sciences, 2023, Oct-10, Volume: 24, Issue:20 Topics: Glioblastoma; Humans; Microtubules; Protein Binding; tau Proteins; Thiazoles; Tubulin	2023