Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and 10074-g5

thiazoles has been researched along with 10074-g5 in 3 studies

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Follis, AV; Hammoudeh, DI; Metallo, SJ; Prochownik, EV; Wang, H1
Beumer, JH; Clausen, DM; Egorin, MJ; Eiseman, JL; Guo, J; Lazo, JS; Parise, RA; Prochownik, EV1
Bister, K; Hart, JR; Hartl, M; Janda, KD; Raffeiner, P; Röck, R; Schraffl, A; Stefan, E; Vogt, PK1

Other Studies

3 other study(ies) available for thiazoles and 10074-g5

ArticleYear
Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules.
    Chemistry & biology, 2008, Nov-24, Volume: 15, Issue:11

    Topics: Amino Acid Sequence; Binding Sites; Humans; Molecular Sequence Data; Mutation; Oxadiazoles; Protein Binding; Protein Conformation; Protein Denaturation; Protein Multimerization; Proto-Oncogene Proteins c-myc; Thiazoles

2008
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:3

    Topics: Animal Structures; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Blood Proteins; Cell Line, Tumor; Cell Survival; Doxorubicin; Feces; Female; Glucuronates; Glucuronidase; HL-60 Cells; Humans; Inhibitory Concentration 50; Liver; Mice; Mice, SCID; Neoplasms; Oxadiazoles; Plasma; Protein Binding; Protein Multimerization; Proto-Oncogene Proteins c-myc; Tandem Mass Spectrometry; Thiazoles; Treatment Outcome; Urine; Xenograft Model Antitumor Assays

2010
In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.
    Oncotarget, 2014, Oct-15, Volume: 5, Issue:19

    Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line, Tumor; Cell Proliferation; HEK293 Cells; Humans; Luciferases, Renilla; Neoplasms; Oxadiazoles; Protein Binding; Protein Multimerization; Proto-Oncogene Proteins c-myc; Pyridines; Repressor Proteins; Thiazoles

2014