Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and (r)-n-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide

thiazoles has been researched along with (r)-n-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (75.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Engers, DW; Hopkins, CR; Huang, X; Le, UM; Li, M; Lin, Z; Lindsley, CW; Long, S; Mattmann, ME; McManus, OB; Wu, M; Xu, K; Yu, H1
Hopkins, CR; Kass, RS; Li, M; Lin, Z; Lindsley, CW; Mattmann, ME; McManus, OB; Terrenoire, C; Wu, M; Yu, H; Zhang, H; Zou, B1
Cook, SA; Huang, D; Islam, O; Liew, R; Liu, Z; Loh, LJ; Lu, J; Ma, D; Shim, W; Wei, H1
Aalto-Setälä, K; Kim, J; Kuusela, J; Räsänen, E1
Chen, L; Gollasch, M; Huang, Y; Kaßmann, M; Lang, F; Schleifenbaum, J; Tano, JY; Tsvetkov, D; Voelkl, J1
Cui, J; Gao, Y; Hou, P; Shi, J; White, KM1
Dou, Y; Eldstrom, J; Fedida, D; McAfee, DA; Wang, Y1
Ataei, F; Dou, Y; Eldstrom, J; Fedida, D; Kyriakis, E; Russo, S; Sahakyan, H; Van Petegem, F; Willegems, K1

Other Studies

8 other study(ies) available for thiazoles and (r)-n-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide

ArticleYear
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.
    Bioorganic & medicinal chemistry letters, 2012, Sep-15, Volume: 22, Issue:18

    Topics: Animals; Dose-Response Relationship, Drug; Humans; KCNQ1 Potassium Channel; Molecular Structure; Piperidines; Rats; Structure-Activity Relationship; Substrate Specificity; Thiazoles; Tosyl Compounds

2012
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, May-21, Volume: 110, Issue:21

    Topics: Action Potentials; Animals; CHO Cells; Cricetinae; Cricetulus; HEK293 Cells; Humans; Ion Transport; KCNQ1 Potassium Channel; Muscle Proteins; Myocytes, Cardiac; Piperidines; Potassium; Potassium Channels, Voltage-Gated; Protein Multimerization; Thiazoles; Tosyl Compounds

2013
Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
    Stem cell research & therapy, 2015, Mar-19, Volume: 6

    Topics: Action Potentials; Adult; Cell Differentiation; Cell Line; Cellular Reprogramming Techniques; Electrocardiography; Female; Humans; Induced Pluripotent Stem Cells; KCNQ1 Potassium Channel; Male; Middle Aged; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channels, Voltage-Gated; RNA, Messenger; Romano-Ward Syndrome; Sequence Deletion; Thiazoles; Tosyl Compounds; Young Adult

2015
The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes.
    Stem cell reviews and reports, 2016, Volume: 12, Issue:6

    Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Bisoprolol; Cells, Cultured; Dose-Response Relationship, Drug; Female; Fractals; Heart Conduction System; Heart Rate; Humans; Induced Pluripotent Stem Cells; Long QT Syndrome; Myocytes, Cardiac; Piperidines; Thiazoles; Time Factors; Tosyl Compounds

2016
Do K
    British journal of pharmacology, 2017, Volume: 174, Issue:2

    Topics: Animals; Aorta; Dose-Response Relationship, Drug; KCNQ1 Potassium Channel; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Structure-Activity Relationship; Thiazoles; Tosyl Compounds

2017
ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling.
    eLife, 2019, 07-22, Volume: 8

    Topics: Animals; Cell Membrane; Cell Polarity; Humans; KCNQ1 Potassium Channel; Long QT Syndrome; Oocytes; Piperidines; Potassium; Potassium Channels, Voltage-Gated; Thiazoles; Tosyl Compounds; Xenopus

2019
ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state.
    The Journal of general physiology, 2021, 12-06, Volume: 153, Issue:12

    Topics: Humans; Induced Pluripotent Stem Cells; KCNQ1 Potassium Channel; Kinetics; Myocytes, Cardiac; Piperidines; Potassium Channels, Voltage-Gated; Thiazoles; Tosyl Compounds

2021
Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
    Nature communications, 2022, 06-29, Volume: 13, Issue:1

    Topics: Animals; KCNQ1 Potassium Channel; Long QT Syndrome; Mutation; Piperidines; Thiazoles; Tosyl Compounds; Xenopus

2022