Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and (2s,3as,7as)-1-(((r,r)-2-phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1h-indole

thiazoles has been researched along with (2s,3as,7as)-1-(((r,r)-2-phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1h-indole in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's7 (87.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barelli, H; Checler, F; De Nanteuil, G; Hirsch, E; Morain, P; Petit, A; Wilk, S1
Barelli, H; Checler, F; Morain, P; Petit, A1
De Nanteuil, G; Guez, D; Heidet, V; Jochemsen, R; Morain, P; Robin, JL1
Giardiniere, M; Morain, P; Schneider, JS1
Boyer, PA; De Nanteuil, G; Guez, D; Jochemsen, R; Lestage, P; Morain, P; Robin, JL1
Bellemère, G; Jégou, S; Morain, P; Vaudry, H2
Carretero, OA; Cavasin, MA; Rhaleb, NE; Yang, XP1

Reviews

1 review(s) available for thiazoles and (2s,3as,7as)-1-(((r,r)-2-phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1h-indole

ArticleYear
S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies.
    CNS drug reviews, 2002,Spring, Volume: 8, Issue:1

    Topics: Aging; Animals; Cognition Disorders; Humans; Indoles; Learning; Memory Disorders; Models, Animal; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Substance P; Thiazoles; Thiazolidines

2002

Trials

1 trial(s) available for thiazoles and (2s,3as,7as)-1-(((r,r)-2-phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1h-indole

ArticleYear
Pharmacodynamic and pharmacokinetic profile of S 17092, a new orally active prolyl endopeptidase inhibitor, in elderly healthy volunteers. A phase I study.
    British journal of clinical pharmacology, 2000, Volume: 50, Issue:4

    Topics: Administration, Oral; Aged; Double-Blind Method; Electroencephalography; Female; Humans; Indoles; Male; Middle Aged; Prolyl Oligopeptidases; Protease Inhibitors; Psychometrics; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Thiazolidines

2000

Other Studies

6 other study(ies) available for thiazoles and (2s,3as,7as)-1-(((r,r)-2-phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1h-indole

ArticleYear
S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase.
    Biochemical and biophysical research communications, 1999, Apr-21, Volume: 257, Issue:3

    Topics: Alzheimer Disease; Aminopeptidases; Brain; Calpain; Cell Line; Cell Membrane; Cell Membrane Permeability; Cell Nucleus; Endopeptidases; Humans; Hydrolysis; Indoles; Inhibitory Concentration 50; Kinetics; Peptidyl-Dipeptidase A; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Thiazoles; Thiazolidines

1999
Novel proline endopeptidase inhibitors do not modify Abeta40/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein.
    British journal of pharmacology, 2000, Volume: 130, Issue:7

    Topics: Amyloid beta-Peptides; Cells, Cultured; Humans; Indoles; Peptide Fragments; Prolyl Oligopeptidases; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Thiazolidines

2000
Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 26, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cognition Disorders; Conditioning, Operant; Discrimination Learning; Dopamine Agents; Indoles; Macaca fascicularis; Male; Parkinson Disease, Secondary; Pattern Recognition, Visual; Prolyl Oligopeptidases; Psychomotor Performance; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Thiazolidines

2002
Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain.
    Journal of neurochemistry, 2003, Volume: 84, Issue:5

    Topics: Administration, Oral; alpha-MSH; Animals; Biological Assay; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Enzyme Activation; Flavobacterium; Frontal Lobe; Hypothalamus; Indoles; Male; Medulla Oblongata; Prolyl Oligopeptidases; Protease Inhibitors; Radioimmunoassay; Rats; Rats, Wistar; Serine Endopeptidases; Substance P; Thiazoles; Thiazolidines

2003
Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dipeptides; Indoles; Kidney; Kidney Cortex; Male; Myocardium; Nitriles; Oligopeptides; Organ Specificity; Proline; Prolyl Oligopeptidases; Protease Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Thiazoles; Thiazolidines; Thymosin

2004
Effect of prolyl endopeptidase inhibition on arginine-vasopressin and thyrotrophin-releasing hormone catabolism in the rat brain.
    Journal of neuroendocrinology, 2005, Volume: 17, Issue:5

    Topics: Amygdala; Animals; Arginine Vasopressin; Brain; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; In Vitro Techniques; Indoles; Male; Nootropic Agents; Protease Inhibitors; Rats; Rats, Wistar; Serine Endopeptidases; Thiazoles; Thiazolidines; Thyrotropin-Releasing Hormone

2005