thiamine pyrophosphate and pyruvic acid

thiamine pyrophosphate has been researched along with pyruvic acid in 94 studies

Research

Studies (94)

TimeframeStudies, this research(%)All Research%
pre-199041 (43.62)18.7374
1990's15 (15.96)18.2507
2000's21 (22.34)29.6817
2010's17 (18.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hugenholtz, J; Snoep, JL; Starrenburg, MJ; Teixeira de Mattos, MJ1
Leadlay, PF; Lowe, PN; Williams, KP1
Elnageh, KM; Gaitonde, MK1
Ali, BH; Czarnecki, CM1
Gathercole, PS; Hofmeyr, JH; Thiel, PG1
Frey, PA; Gruys, KJ; Steginsky, CA1
Barron, LL; Olson, MS; Robertson, JG1
Milani, A; Neher, R1
Chen, G; Jordan, F; Nishikawa, S; Wu, BS1
Khailova, LS; Nemerya, NS; Severin, SE1
Krampitz, LO1
Frey, PA3
Kluger, R1
Hübner, G; Khailova, LS; Neef, H; Schellenberger, A; Severin, SE1
Khailova, LS; Korotchkina, LG; Severin, SE1
Chernikevich, IP; Kivach, LN; Maskevich, AA; Maskevich, SA; Oparin, DA; Zabrodskaia, SV1
Khailova, LS; Nemerya, NS; Nyukhalkina, IA; Zemskova, MA1
Menon, S; Ragsdale, SW2
Chang, AK; Duggleby, RG2
Bisswanger, H; Hennig, J; Hübner, G; Kern, G; Neef, H; Spinka, M1
Baburina, I; Furey, W; Gao, Y; Guest, JR; Guo, F; Jordan, F; Kahyaoglu, A; Li, H; Nemeria, N; Wang, J; Yi, J1
Candy, JM; Duggleby, RG1
Frontali, L; Meacock, P; Tizzani, L; Wésolowski-Louvel, M1
Korotchkina, LG; Patel, MS; Tripatara, A1
Chabriere, E; Charon, MH; Fontecilla-Camps, JC; Pieulle, L; Volbeda, A1
Baumann, S; Dobritzsch, D; König, S; Lu, G; Schneider, G1
Andersson, LA; Baker, JC; Cole, AB; Gong, X; Li, L; Liu, S; Peng, T; Ravindran, S; Robben, PM; Roche, TE; Yan, X1
Chabrière, E; Charon, MH; Fontecilla-Camps, JC; Guigliarelli, B; Hatchikian, EC; Vernède, X1
Butler, IS; Hadjiliadis, N; Louloudi, M; Vartzouma, Ch1
Jordan, F; Sergienko, E; Zhang, Z1
ARAKAWA, T1
LASCH, F1
PANSINI, R; SOZIO, N1
BREHM, G; KORTING, GW1
NAVAZIO, F; SILIPRANDI, N1
AL BERMANI, MA; GREIF, S; HOCHEGGER, M1
HUTSCHENREUTER, K1
BENDA, L; DONEFF, D; MOSER, K1
JARVINEN, PA; WIDHOLM, O2
CASELLATO, R; SCARPA, P1
GOEDDE, HW; GOEGGEL, KH; HOLZER, H; ULRICH, B1
KARDASZEWICZ, S; MASNY, N1
FERSINI, C; RIPA, R1
HOLZER, H; KOHLHAW, G; WOENCKHAUS, CW1
HOLZER, H; ULLRICH, J1
HENNING, U1
BERGQUIST, A; KIRITANI, K; NARISE, S; WAGNER, RP1
KIESSLING, KH; LUNDQUIST, CG2
PANSINI, R; RIPA, R1
Baek, DK; Choi, JD; Choi, MK; Hwang, JH; Kim, J; Kim, YT; Yoon, MY1
GILLILAND, IC; MARTIN, MM1
SURIYONG, R1
CATTANEO, R1
GRUBER, M; MEYER, FG1
de LOZE, C1
LIU, KT1
FAVACCHIO, G1
Barak, Z; Chipman, DM; Duggleby, RG; Golbik, R; Hübner, G; Kaplun, A; McCourt, J; Schröder, K; Tittmann, K1
Jordan, F; Liu, M; Yan, Y; Zhang, S; Zhang, Z1
Frank, RA; Luisi, BF; Perham, RN; Pratap, JV; Titman, CM1
Duggleby, RG; McCourt, JA1
Ghisla, S; Golbik, R; Hübner, G; Tittmann, K; Weidner, A; Wille, G1
Celik, L; Jørgensen, KA; Lie, MA; Schiøtt, B1
Cavazza, C; Chabrière, E; Contreras-Martel, C; Fontecilla-Camps, JC; Hatchikian, EC; Pieulle, L1
Golbik, R; Hinze, E; Meyer, D; Steinmetz, A; Tittmann, K; Wille, G1
Baykal, A; Chakraborty, S; Dodoo, A; Jordan, F1
Cremades, N; Croxen, MA; Harman, WD; Hoffman, PS; Morash, MG; Sisson, G; Welch, K1
Batifoulier, F; Besson, C; Chanliaud, E; Demigné, C; Rémésy, C; Verny, MA1
GRUBER, M; MEIJER, FG; MONFOORT, CH1
Tittmann, K1
Akhtar, MK; Jones, PR1
Alderete, J; Delgado, E; Jaña, G; Jiménez, V; Prat-Resina, X; Villà-Freixa, J1
Andrews, FH; McLeish, MJ1
Alvarado, O; Delgado, EJ; Jaña, G1
Balakrishnan, A; Barak, Z; Binshtein, E; Chipman, D; Jordan, F; Nemeria, N; Patel, H; Shaanan, B; Vered, I1
Atteia, A; Baffert, C; Couté, Y; Nitschke, W; van Lis, R1
de Assis, LJ; Masuda, CA; Montero-Lomelí, M; Rodrigues, SP; Zingali, RB1
Baig, IA; Chien, PN; Jung, IP; La, IJ; Lee, SC; Yoon, MY1
Andrade, SL; Giovannini, PP; Loschonsky, S; McLeish, MJ; Müller, M; Wacker, T; Waltzer, S1
Bourenkov, G; Brück, T; Garbe, D; Haack, M; Langner, C; Loll, B; Qoura, F; Sommer, B; von Moeller, H1
Delgado, EJ; Jaña, GA; Lizana, I1
Li, Y; Liu, Y; Wang, X1
Andrews, ES; Arcus, VL; Buddrus, L; Crennell, SJ; Danson, MJ; Leak, DJ1
Deng, H; Deng, Z; Kyeremeh, K; Lv, M; Su, L; Yu, Y1
Aklinski, JL; Bartee, D; DeColli, AA; Freel Meyers, CL; Harrison, MJ; Koppisch, AT; Sanders, S; Vierling, RJ1
Baierl, A; Dobritzsch, D; Fries, A; Hampel, S; Lehwald, P; Müller, M; Pohl, M; Richter, M; Schneider, G; Steitz, JP; Wiesli, L1
Bettendorff, L; El Moualij, B; Gigliobianco, T; Lakaye, B; Wins, P; Zorzi, W1
Bettendorff, L; Gangolf, M; Gigliobianco, T; Lakaye, B; Pirson, B; von Ballmoos, C; Wins, P1

Reviews

8 review(s) available for thiamine pyrophosphate and pyruvic acid

ArticleYear
Thiamin: twenty years ago.
    Annals of the New York Academy of Sciences, 1982, Volume: 378

    Topics: Acetaldehyde; Acetoin; Acetolactate Synthase; Animals; Bacteria; Carbon Dioxide; Chemical Phenomena; Chemistry; Formaldehyde; Hexosephosphates; Lactates; Oxaloacetates; Pentosephosphates; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate; Transketolase

1982
Mechanism of coupled electron and group transfer in Escherichia coli pyruvate dehydrogenase.
    Annals of the New York Academy of Sciences, 1982, Volume: 378

    Topics: Acetyl Coenzyme A; Acetylation; Binding Sites; Chemical Phenomena; Chemistry; Coenzyme A; Electron Transport; Escherichia coli; Flavin-Adenine Dinucleotide; Molecular Weight; NAD; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Spectrophotometry; Thiamine Pyrophosphate; Thioctic Acid

1982
Regulation of thiamin diphosphate-dependent 2-oxo acid decarboxylases by substrate and thiamin diphosphate.Mg(II) - evidence for tertiary and quaternary interactions.
    Biochimica et biophysica acta, 1998, Jun-29, Volume: 1385, Issue:2

    Topics: Binding Sites; Crystallography, X-Ray; Enzyme Activation; Magnesium; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Tertiary; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thiamine Pyrophosphate

1998
Structure and properties of pyruvate decarboxylase and site-directed mutagenesis of the Zymomonas mobilis enzyme.
    Biochimica et biophysica acta, 1998, Jun-29, Volume: 1385, Issue:2

    Topics: Amino Acid Sequence; Binding Sites; Catalysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyruvate Decarboxylase; Pyruvic Acid; Thiamine Pyrophosphate; Zymomonas

1998
Structure and electron transfer mechanism of pyruvate:ferredoxin oxidoreductase.
    Current opinion in structural biology, 1999, Volume: 9, Issue:6

    Topics: Electron Transport; Ketone Oxidoreductases; Models, Molecular; Protein Binding; Protein Conformation; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate

1999
Reaction mechanisms of thiamin diphosphate enzymes: redox reactions.
    The FEBS journal, 2009, Volume: 276, Issue:9

    Topics: Animals; Catalysis; Crystallography, X-Ray; Electron Transport; Humans; Kinetics; Models, Molecular; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvate Oxidase; Pyruvic Acid; Structure-Activity Relationship; Thiamine Pyrophosphate

2009
Substrate specificity in thiamin diphosphate-dependent decarboxylases.
    Bioorganic chemistry, 2012, Volume: 43

    Topics: Acyl Coenzyme A; Bacteria; Carboxy-Lyases; Catalytic Domain; Glyoxylates; Mandelic Acids; Mutagenesis, Site-Directed; Pyruvic Acid; Saccharomyces cerevisiae; Substrate Specificity; Thiamine Pyrophosphate

2012
Acetohydroxyacid synthases: evolution, structure, and function.
    Applied microbiology and biotechnology, 2016, Volume: 100, Issue:20

    Topics: Acetolactate Synthase; Butyrates; Coenzymes; Evolution, Molecular; Hydroxybutyrates; Lactates; Protein Conformation; Pyruvic Acid; Thiamine Pyrophosphate

2016

Other Studies

86 other study(ies) available for thiamine pyrophosphate and pyruvic acid

ArticleYear
Isolation, characterization, and physiological role of the pyruvate dehydrogenase complex and alpha-acetolactate synthase of Lactococcus lactis subsp. lactis bv. diacetylactis.
    Journal of bacteriology, 1992, Volume: 174, Issue:14

    Topics: Acetolactate Synthase; Cations, Divalent; Chromatography, High Pressure Liquid; Kinetics; Lactococcus lactis; NAD; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1992
Inhibition of pyruvate:ferredoxin oxidoreductase from Trichomonas vaginalis by pyruvate and its analogues. Comparison with the pyruvate decarboxylase component of the pyruvate dehydrogenase complex.
    The Biochemical journal, 1990, May-15, Volume: 268, Issue:1

    Topics: Animals; Binding Sites; Carboxy-Lyases; Coenzyme A; Dithiothreitol; Escherichia coli; Ketone Oxidoreductases; Kinetics; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvate Synthase; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate; Trichomonas vaginalis

1990
Effect of a deficiency of thiamine on brain pyruvate dehydrogenase: enzyme assay by three different methods.
    Journal of neurochemistry, 1988, Volume: 51, Issue:5

    Topics: Animals; Brain; Carbon Dioxide; Coloring Agents; Enzyme Activation; Kinetics; Male; Mitochondria; NAD; Oxidation-Reduction; Pyrithiamine; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Tetrazolium Salts; Thiamine Deficiency; Thiamine Pyrophosphate

1988
Ethanol-induced alteration in thiamin status of young turkey poults.
    General pharmacology, 1987, Volume: 18, Issue:2

    Topics: Animals; Body Weight; Erythrocytes; Ethanol; Heart; Lactates; Lactic Acid; Male; Organ Size; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate; Transketolase; Turkeys

1987
Inhibition of pyruvate dehydrogenase complex by moniliformin.
    The Biochemical journal, 1986, Feb-01, Volume: 233, Issue:3

    Topics: Cyclobutanes; Dialysis; Kinetics; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1986
alpha-Ketoglutarate dehydrogenase complex of Escherichia coli. A hybrid complex containing pyruvate dehydrogenase subunits from pyruvate dehydrogenase complex.
    The Journal of biological chemistry, 1985, Nov-05, Volume: 260, Issue:25

    Topics: Acetylation; Escherichia coli; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Ketone Oxidoreductases; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1985
Effects of alpha-ketoisovalerate on bovine heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase.
    The Journal of biological chemistry, 1986, Jan-05, Volume: 261, Issue:1

    Topics: Animals; Cattle; Electrophoresis, Polyacrylamide Gel; Hemiterpenes; Keto Acids; Kinetics; Myocardium; Potassium Chloride; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Substrate Specificity; Thiamine Pyrophosphate

1986
Pyruvate and thiamine pyrophosphate potentiate cyclic nucleotide-induced steroidogenesis in isolated rat adrenocortical cells.
    Journal of steroid biochemistry, 1983, Volume: 18, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Citric Acid Cycle; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Oxaloacetates; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate

1983
Potential roles of the aminopyrimidine ring in thiamin catalyzed reactions.
    Annals of the New York Academy of Sciences, 1982, Volume: 378

    Topics: Chemical Phenomena; Chemistry; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Oxythiamine; Protons; Pyrimidines; Pyruvates; Pyruvic Acid; Structure-Activity Relationship; Thiamine; Thiamine Pyrophosphate

1982
The substrate-mediated inactivation of the pyruvate dehydrogenase component of the pigeon breast muscle pyruvate dehydrogenase complex.
    Biochemistry international, 1983, Volume: 7, Issue:4

    Topics: Animals; Carbon Radioisotopes; Columbidae; Kinetics; Muscles; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1983
Reactive intermediates in thiamin catalysis.
    Annals of the New York Academy of Sciences, 1982, Volume: 378

    Topics: Drug Stability; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Oxythiamine; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate

1982
Effect of pyruvate and its analogs on the thiamine pyrophosphate binding in the active center of muscle pyruvate dehydrogenase.
    FEBS letters, 1982, Mar-08, Volume: 139, Issue:1

    Topics: 2,6-Dichloroindophenol; Animals; Butyrates; Chemical Phenomena; Chemistry; Columbidae; Muscles; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1982
The effect of phosphorylation on pyruvate dehydrogenase.
    FEBS letters, 1995, May-08, Volume: 364, Issue:2

    Topics: Adenosine Triphosphate; Animals; Binding Sites; Circular Dichroism; Columbidae; In Vitro Techniques; Kinetics; Muscles; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Substrate Specificity; Thiamine Pyrophosphate

1995
[Spectroscopic study of the structure and intramolecular mobility of yeast pyruvate decarboxylase].
    Bioorganicheskaia khimiia, 1993, Volume: 19, Issue:12

    Topics: Anilino Naphthalenesulfonates; Binding Sites; Fluorescent Dyes; Luminescent Measurements; Protein Conformation; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Sulfhydryl Reagents; Thiamine; Thiamine Pyrophosphate

1993
Chemical modification of the essential arginine residues of pyruvate dehydrogenase prevents its phosphorylation by kinase.
    FEBS letters, 1996, Sep-23, Volume: 394, Issue:1

    Topics: Animals; Arginine; Binding Sites; Columbidae; Muscle, Skeletal; Phosphorylation; Phosphoserine; Protein Kinases; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thiamine Pyrophosphate

1996
Unleashing hydrogenase activity in carbon monoxide dehydrogenase/acetyl-CoA synthase and pyruvate:ferredoxin oxidoreductase.
    Biochemistry, 1996, Dec-10, Volume: 35, Issue:49

    Topics: Acetyl Coenzyme A; Aldehyde Oxidoreductases; Binding Sites; Carbon Monoxide; Clostridium; Electron Transport; Hydrogen; Hydrogenase; Ketone Oxidoreductases; Kinetics; Multienzyme Complexes; Oxidation-Reduction; Paraquat; Potassium Cyanide; Protons; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate

1996
Mechanism of the Clostridium thermoaceticum pyruvate:ferredoxin oxidoreductase: evidence for the common catalytic intermediacy of the hydroxyethylthiamine pyropyrosphate radical.
    Biochemistry, 1997, Jul-15, Volume: 36, Issue:28

    Topics: Clostridium; Coenzyme A; Electron Spin Resonance Spectroscopy; Free Radicals; Iron; Iron-Sulfur Proteins; Ketone Oxidoreductases; Kinetics; Molecular Structure; Oxidation-Reduction; Paraquat; Protein Binding; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate

1997
Expression, purification and characterization of Arabidopsis thaliana acetohydroxyacid synthase.
    The Biochemical journal, 1997, Oct-01, Volume: 327 ( Pt 1)

    Topics: Acetolactate Synthase; Arabidopsis; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Flavin-Adenine Dinucleotide; Gene Expression; Imidazoles; Kinetics; Molecular Weight; Niacin; Peptide Fragments; Pyruvic Acid; Recombinant Proteins; Sequence Analysis; Sulfonamides; Thiamine Pyrophosphate; Triazines

1997
Molecular mechanism of regulation of the pyruvate dehydrogenase complex from E. coli.
    Biochemistry, 1997, Dec-16, Volume: 36, Issue:50

    Topics: Coenzymes; Diethyl Pyrocarbonate; Enzyme Activation; Escherichia coli; Kinetics; NAD; Protein Binding; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Spectrometry, Fluorescence; Thiamine Pyrophosphate; Tryptophan

1997
Herbicide-resistant forms of Arabidopsis thaliana acetohydroxyacid synthase: characterization of the catalytic properties and sensitivity to inhibitors of four defined mutants.
    The Biochemical journal, 1998, Aug-01, Volume: 333 ( Pt 3)

    Topics: Acetolactate Synthase; Arabidopsis; Catalysis; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Flavin-Adenine Dinucleotide; Herbicides; Hydrogen-Ion Concentration; Kinetics; Magnesium; Mutation; Pyruvic Acid; Sensitivity and Specificity; Substrate Specificity; Thiamine Pyrophosphate

1998
The RAG3 gene of Kluyveromyces lactis is involved in the transcriptional regulation of genes coding for enzymes implicated in pyruvate utilization and genes of the biosynthesis of thiamine pyrophosphate.
    FEMS microbiology letters, 1998, Nov-01, Volume: 168, Issue:1

    Topics: Blotting, Northern; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Kluyveromyces; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; RNA, Bacterial; Thiamine Pyrophosphate; Transcription, Genetic

1998
Characterization of point mutations in patients with pyruvate dehydrogenase deficiency: role of methionine-181, proline-188, and arginine-349 in the alpha subunit.
    Archives of biochemistry and biophysics, 1999, Jul-01, Volume: 367, Issue:1

    Topics: 2,6-Dichloroindophenol; Acetylation; Acetyltransferases; Amino Acid Substitution; Apoenzymes; Arginine; Binding Sites; Circular Dichroism; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Stability; Humans; Kinetics; Methionine; Point Mutation; Proline; Protein Structure, Secondary; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvic Acid; Recombinant Proteins; Thermodynamics; Thiamine Pyrophosphate

1999
The structural basis of substrate activation in yeast pyruvate decarboxylase. A crystallographic and kinetic study.
    European journal of biochemistry, 2000, Volume: 267, Issue:3

    Topics: Catalytic Domain; Crystallography, X-Ray; Enzyme Activation; Kinetics; Models, Molecular; Protein Structure, Quaternary; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae; Static Electricity; Substrate Specificity; Thiamine Pyrophosphate

2000
Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
    Archives of biochemistry and biophysics, 2001, Feb-15, Volume: 386, Issue:2

    Topics: Acetylation; Acetyltransferases; Animals; Cattle; Circular Dichroism; Dihydrolipoamide Dehydrogenase; Dihydrolipoyllysine-Residue Acetyltransferase; Humans; Kinetics; Models, Molecular; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thermodynamics; Thiamine Pyrophosphate; Thioctic Acid

2001
Enzymology. Coenzymes and radicals.
    Science (New York, N.Y.), 2001, Dec-21, Volume: 294, Issue:5551

    Topics: Catalysis; Catalytic Domain; Chemical Phenomena; Chemistry, Physical; Coenzyme A; Coenzymes; Crystallization; Crystallography, X-Ray; Electrons; Ferredoxins; Ferricyanides; Free Radicals; Ketone Oxidoreductases; Molecular Structure; Oxidation-Reduction; Protons; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate

2001
Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase.
    Science (New York, N.Y.), 2001, Dec-21, Volume: 294, Issue:5551

    Topics: Acetyl Coenzyme A; Anaerobiosis; Binding Sites; Carbon Dioxide; Catalysis; Chemical Phenomena; Chemistry, Physical; Coenzymes; Crystallization; Crystallography, X-Ray; Desulfovibrio; Dimerization; Electron Spin Resonance Spectroscopy; Free Radicals; Ketone Oxidoreductases; Molecular Conformation; Molecular Structure; Oxidation-Reduction; Protein Conformation; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate

2001
Practical tethering of vitamin B1 on a silica surface via its phosphate group and evaluation of its activity.
    Chemical communications (Cambridge, England), 2002, Mar-07, Issue:5

    Topics: Catalysis; Cross-Linking Reagents; Decarboxylation; Phosphates; Pyruvate Decarboxylase; Pyruvic Acid; Silicon Dioxide; Thiamine; Thiamine Pyrophosphate

2002
Spectroscopic evidence for participation of the 1',4'-imino tautomer of thiamin diphosphate in catalysis by yeast pyruvate decarboxylase.
    Bioorganic chemistry, 2002, Volume: 30, Issue:3

    Topics: Acetaldehyde; Binding Sites; Catalysis; Circular Dichroism; Holoenzymes; Isomerism; Models, Chemical; Models, Molecular; Protein Conformation; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Spectrum Analysis; Thiamine Pyrophosphate; Yeasts

2002
The existence of co-carboxylase in human milk. Part 1. Influence of human milk upon decarboxylation of pyruvate by alkaline washed yeast carboxylase; 218th report of the peroxidase reaction.
    The Tohoku journal of experimental medicine, 1952, Volume: 56, Issue:1-2

    Topics: Decarboxylation; Milk, Human; Oxidation-Reduction; Peroxidases; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1952
[Pyruvic acid and cocarboxylase; the importance of pyruvic acid determination in blood for clinical diagnosis and the effects of cocarboxylase on the increased pyruvic acid blood level].
    Deutsche medizinische Wochenschrift (1946), 1953, Jul-03, Volume: 78, Issue:27-28

    Topics: Humans; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1953
[Research on muscle physiopathology in man. III. Variations in the endogenous blood alcohol, pyruvic acid and glucose in the venous circulation after cocarboxylase load in muscle diseases].
    Bollettino della Societa italiana di biologia sperimentale, 1953, Volume: 29, Issue:4

    Topics: Blood; Blood Glucose; Disease; Ethanol; Glucose; Humans; Male; Muscles; Muscular Diseases; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate; Veins

1953
[Additional studies on the pyruvic acid level in blood and skin blisters and its control by cocarboxylase and thioctin acid].
    Archiv fur klinische und experimentelle Dermatologie, 1955, Volume: 201, Issue:2

    Topics: Blister; Blood; Body Fluids; Inorganic Chemicals; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate

1955
The action of cocarboxylase on pyruvate utilisation and citrate formation in the liver of normal and diabetic rats.
    Enzymologia, 1955, Dec-15, Volume: 17, Issue:4

    Topics: Animals; Citrates; Citric Acid; Diabetes Mellitus, Experimental; Liver; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate

1955
[Pyruvic acid & cocarboxylase in cardiac decompensation].
    Wiener klinische Wochenschrift, 1957, Aug-16, Volume: 69, Issue:33

    Topics: Heart Failure; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1957
[Postoperative cocarboxylase therapy by control of pyruvic acid in blood].
    Der Anaesthesist, 1957, Volume: 6, Issue:5

    Topics: Humans; Postoperative Period; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1957
[Effect of cocarboxylase on blood pyruvic acid in cardiac decompensation and digitalis intoxication].
    Zeitschrift fur Kreislaufforschung, 1958, Volume: 47, Issue:5-6

    Topics: Cardiovascular Agents; Digitalis; Heart Failure; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1958
[Pyruvic acid content of blood in toxemias & hyperemesis gravidarum & the effect of cocarboxylase].
    Annales medicinae experimentalis et biologiae Fenniae, 1958, Volume: 36, Issue:3

    Topics: Female; Humans; Hyperemesis Gravidarum; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pyruvic Acid; Thiamine Pyrophosphate; Toxemia; Vomiting

1958
Blood pyruvic acid concentration in carcinoma during radiotherapy: with especial consideration of the effect of cocarboxylase and thiamine monophosphate.
    Annales medicinae internae Fenniae. Supplementum, 1959, Volume: 48, Issue:Supp 28

    Topics: Carcinoma; Genitalia; Genitalia, Female; Neoplasms; Pyruvates; Pyruvic Acid; Radiotherapy; Thiamine Monophosphate; Thiamine Pyrophosphate

1959
[Behavior of cocarboxyiase and pyruvic acid in rats subjected to various hypolipidic diets].
    Clinical radiology, 1960, Volume: 42(12)Suppl

    Topics: Animals; Diet; Lipids; Liver; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate

1960
Identification of alpha-hydroxyethyl thiamine pyrophosphate ("active acetaldehyde") as an intermediate in the oxidation of pyruvate by pyruvic oxidase from yeast mitochondria.
    Biochemical and biophysical research communications, 1960, Volume: 3

    Topics: Acetaldehyde; Mitochondria; Oxidation-Reduction; Oxidoreductases; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae; Thiamine Pyrophosphate; Yeasts

1960
[Pyruvic acid level in the blood and attempted use of cocarboxylase (berolase) in circulatory insufficiency].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1961, Jan-30, Volume: 16

    Topics: Heart Failure; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1961
[The pyruvate-ethanol changes after loading with cocarboxylase in diabetics].
    L' Arcispedale S. Anna di Ferrara, 1962, Volume: 15

    Topics: Diabetes Mellitus; Ethanol; Humans; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1962
Active forms of acetaldehyde, pyruvate, and glycolic aldehyde.
    Annals of the New York Academy of Sciences, 1962, Apr-26, Volume: 98

    Topics: Acetaldehyde; Aldehydes; Biochemical Phenomena; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1962
[THE PH FACTOR IN THE 2-(L-HYDROXY-ETHYL)-THIAMINE PYROPHOSPHATE YIELD IN THE TRANSFORMATION OF PYRUVATE WITH THIAMINE PYROPHOSPHATE TO PYRUVATE OXIDASE FROM SWINE MYOCARDIUM].
    Biochemische Zeitschrift, 1963, Jul-10, Volume: 337

    Topics: Animals; Diphosphates; Hydrogen-Ion Concentration; Myocardium; Pyruvate Oxidase; Pyruvates; Pyruvic Acid; Research; Swine; Thiamine; Thiamine Pyrophosphate

1963
[A REGULATORY MECHANISM IN THE DEGRADATION OF PYRUVIC ACID BY ESCHERICHIA COLI].
    Biochemische Zeitschrift, 1963, Jul-26, Volume: 337

    Topics: Coenzyme A; Escherichia coli; Formates; Oxidoreductases; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1963
THE OVERALL IN VITRO SYNTHESIS OF VALINE FROM PYRUVATE BY NEUROSPORA HOMOGENATES.
    Biochimica et biophysica acta, 1965, May-04, Volume: 100

    Topics: Amino Acids; Calcium; Edetic Acid; Hydro-Lyases; Hydrogen-Ion Concentration; In Vitro Techniques; Isomerases; Keto Acids; Lyases; Magnesium; NAD; Neurospora; Pyruvates; Pyruvic Acid; Research; Sucrose; Thiamine Pyrophosphate; Transaminases; Valine

1965
Thiamine diphosphate in growing tissues. III. Pyruvate oxidation in liver mitochondria from young and from thiamine diphosphate deficient adult rats.
    Experimental cell research, 1962, Volume: 26

    Topics: Animals; Mitochondria; Mitochondria, Liver; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate

1962
Thiamine diphosphate in growing tissues. IV. Pyruvate oxidation in muscle mitochondria from young rats and in mitochondria from malignant tissues.
    Experimental cell research, 1962, Volume: 26

    Topics: Animals; Mitochondria; Mitochondria, Muscle; Muscles; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate

1962
[The cocarboxylase test of the normal relations between endogenous arteriovenous blood alcohol and the pyruvate phase of intermediate metabolism in normal persons and patients with liver disease].
    L' Arcispedale S. Anna di Ferrara, 1961, Volume: 14

    Topics: Alcohols; Biochemical Phenomena; Digestion; Humans; Liver Diseases; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate

1961
The active site and mechanism of action of recombinant acetohydroxy acid synthase from tobacco.
    FEBS letters, 2003, Dec-04, Volume: 555, Issue:2

    Topics: Acetolactate Synthase; Binding Sites; Catalysis; Ethanol; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nicotiana; Pyruvic Acid; Recombinant Proteins; Temperature; Thermodynamics; Thiamine Pyrophosphate; Water

2003
Raised blood pyruvic acid level in diabetic acidosis; the value of cocarboxylase in treatment.
    British medical journal, 1951, Jan-06, Volume: 1, Issue:4696

    Topics: Diabetes Mellitus; Diabetic Ketoacidosis; Pyruvic Acid; Thiamine Pyrophosphate

1951
[Clinical investigations on the action of cocarboxylase].
    Helvetica medica acta, 1950, Volume: 17, Issue:4-5

    Topics: Blood; Pyruvic Acid; Sjogren's Syndrome; Thiamine; Thiamine Pyrophosphate

1950
[Thiamine, cocarboxylase and pyruvic acid metabolism in liver disease after glucose load].
    Archivio per le scienze mediche, 1951, Volume: 91, Issue:1

    Topics: Blood; Glucose; Humans; Liver Diseases; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate

1951
A study of the influence of thiamine and thiamine pyrophosphate on the anaerobic pyruvate metabolism of pig heart muscle.
    Biochimica et biophysica acta, 1951, Volume: 6, Issue:3

    Topics: Animals; Biochemical Phenomena; Myocardium; Pyruvic Acid; Sus scrofa; Swine; Thiamine; Thiamine Pyrophosphate

1951
[The ultraviolet spectra of aneurin and cocarboxylase in the presence of the ethyl pyruvate and mixture of acetaldehyde and pyruvic acid].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1951, Jun-18, Volume: 232, Issue:25

    Topics: Acetaldehyde; Pyruvates; Pyruvic Acid; Spectrum Analysis; Thiamine; Thiamine Pyrophosphate

1951
[Effect of previous or simultaneous application of cocarboxylase, ribonuclease, pyruvic acid and quinine on the response of the isolated frog heart to convallatoxin].
    Archives internationales de pharmacodynamie et de therapie, 1951, Sep-01, Volume: 87, Issue:4

    Topics: Animals; Anura; Cardiac Glycosides; Heart; Pyruvic Acid; Quinine; Ribonucleases; Strophanthins; Thiamine Pyrophosphate

1951
[Amount of pyruvic acid in blood of surgical subjects with pentothal-curare-ether narcosis and the action of co-carboxylase].
    Il Policlinico. Sezione chirurgica, 1952, Volume: 59, Issue:3

    Topics: Carboxy-Lyases; Curare; Ether; Ethers; Humans; Pyruvates; Pyruvic Acid; Stupor; Thiamine Pyrophosphate; Thiopental

1952
Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme.
    Biochemistry, 2004, Jul-13, Volume: 43, Issue:27

    Topics: Acetolactate Synthase; Catalysis; Electron Transport; Flavin-Adenine Dinucleotide; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Oxygen; Pyruvic Acid; Spectrum Analysis; Thiamine Pyrophosphate

2004
C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models.
    The Journal of biological chemistry, 2004, Dec-24, Volume: 279, Issue:52

    Topics: Acetaldehyde; Decarboxylation; Diphosphates; Escherichia coli; Furans; Kinetics; Molecular Conformation; Oxythiamine; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Saccharomyces cerevisiae; Thiamine Pyrophosphate

2004
A molecular switch and proton wire synchronize the active sites in thiamine enzymes.
    Science (New York, N.Y.), 2004, Oct-29, Volume: 306, Issue:5697

    Topics: Amino Acid Substitution; Binding Sites; Catalysis; Crystallography, X-Ray; Dihydrolipoyllysine-Residue Acetyltransferase; Geobacillus stearothermophilus; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Mutation; Phosphorylation; Protein Conformation; Protein Folding; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein Subunits; Protons; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thiamine Pyrophosphate

2004
How an enzyme answers multiple-choice questions.
    Trends in biochemical sciences, 2005, Volume: 30, Issue:5

    Topics: Acetolactate Synthase; Molecular Structure; Pyruvic Acid; Substrate Specificity; Thiamine Pyrophosphate

2005
Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum. Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FA
    Biochemistry, 2005, Oct-11, Volume: 44, Issue:40

    Topics: Catalysis; Electrons; Flavin-Adenine Dinucleotide; Flavins; Fluorescence Resonance Energy Transfer; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Lactobacillus plantarum; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Statistical; Oxidation-Reduction; Oxygen; Phosphates; Pyruvate Oxidase; Pyruvic Acid; Solvents; Spectrophotometry; Temperature; Thermodynamics; Thiamine Pyrophosphate; Time Factors

2005
Cofactor activation and substrate binding in pyruvate decarboxylase. Insights into the reaction mechanism from molecular dynamics simulations.
    Biochemistry, 2005, Nov-15, Volume: 44, Issue:45

    Topics: Binding Sites; Catalytic Domain; Computer Simulation; Hydrogen Bonding; Models, Chemical; Models, Molecular; Mutation; Pyruvate Decarboxylase; Pyruvic Acid; Thiamine Pyrophosphate; Zymomonas

2005
Flexibility of thiamine diphosphate revealed by kinetic crystallographic studies of the reaction of pyruvate-ferredoxin oxidoreductase with pyruvate.
    Structure (London, England : 1993), 2006, Volume: 14, Issue:2

    Topics: Anaerobiosis; Crystallography, X-Ray; Kinetics; Models, Molecular; Motion; Oxygen; Pyruvate Synthase; Pyruvic Acid; Structural Homology, Protein; Thiamine Pyrophosphate; Transketolase

2006
The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Binding Sites; Catalysis; Crystallography; Crystallography, X-Ray; Enzyme Activation; Lactobacillus plantarum; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Pyruvate Oxidase; Pyruvic Acid; Reference Standards; Structure-Activity Relationship; Thiamine Pyrophosphate

2006
Snapshots of three intermediates at the active site of pyruvate oxidase.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Binding Sites; Crystallography; Crystallography, X-Ray; Enzyme Activation; Molecular Conformation; Pyruvate Oxidase; Pyruvic Acid; Structure-Activity Relationship; Thiamine Pyrophosphate

2006
Synthesis with good enantiomeric excess of both enantiomers of alpha-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases.
    Bioorganic chemistry, 2006, Volume: 34, Issue:6

    Topics: Acetone; Binding Sites; Carboxy-Lyases; Escherichia coli Proteins; Ketone Oxidoreductases; Ketones; Lactates; Mutation, Missense; Pyruvate Decarboxylase; Pyruvic Acid; Saccharomyces cerevisiae Proteins; Stereoisomerism; Thiamine Pyrophosphate

2006
Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:3

    Topics: Acetyl Coenzyme A; Animals; Antiprotozoal Agents; Bacteria, Anaerobic; Campylobacter jejuni; Carbon Dioxide; Cloning, Molecular; Clostridium; Culture Media; Enzyme Inhibitors; Helicobacter pylori; Kinetics; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Nitro Compounds; Parasites; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Reverse Transcriptase Polymerase Chain Reaction; Thiamine Pyrophosphate; Thiazoles

2007
Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2007, Volume: 77, Issue:1

    Topics: Animals; Body Weight; Bread; Cerebellum; Diet; Disease Models, Animal; Glucose; Glutamic Acid; Kidney; Lactic Acid; Liver; Pyruvic Acid; Rats; Rats, Wistar; Thiamine; Thiamine Deficiency; Thiamine Pyrophosphate; Triticum

2007
Influence of aneurin and aneurin pyrophosphate on anaerobic pyruvate metabolism of pig heart muscle in vitro.
    Nature, 1949, Jun-11, Volume: 163, Issue:4154

    Topics: Animals; Diphosphates; In Vitro Techniques; Myocardium; Pyruvic Acid; Sus scrofa; Swine; Thiamine; Thiamine Pyrophosphate

1949
Construction of a synthetic YdbK-dependent pyruvate:H2 pathway in Escherichia coli BL21(DE3).
    Metabolic engineering, 2009, Volume: 11, Issue:3

    Topics: Bacillus subtilis; Bacterial Proteins; Clostridium; Clostridium acetobutylicum; Escherichia coli; Escherichia coli Proteins; Ferredoxins; Hydrogen; Metabolic Networks and Pathways; Models, Biological; Pyruvic Acid; Thiamine Pyrophosphate; Transcription Factors

2009
Computational study on the carboligation reaction of acetohidroxyacid synthase: new approach on the role of the HEThDP- intermediate.
    Proteins, 2010, May-15, Volume: 78, Issue:7

    Topics: Acetolactate Synthase; Amino Acids; Catalytic Domain; Fungal Proteins; Lactates; Molecular Dynamics Simulation; Pyruvic Acid; Thermodynamics; Thiamine Pyrophosphate; Yeasts

2010
Computer-assisted study on the reaction between pyruvate and ylide in the pathway leading to lactyl-ThDP.
    Journal of computer-aided molecular design, 2012, Volume: 26, Issue:8

    Topics: Binding Sites; Catalysis; Computer Simulation; Models, Chemical; Pyruvic Acid; Thermodynamics; Thiamine Pyrophosphate

2012
Glyoxylate carboligase: a unique thiamin diphosphate-dependent enzyme that can cycle between the 4'-aminopyrimidinium and 1',4'-iminopyrimidine tautomeric forms in the absence of the conserved glutamate.
    Biochemistry, 2012, Oct-09, Volume: 51, Issue:40

    Topics: Amino Acid Substitution; Circular Dichroism; Gene Expression Regulation; Glutamic Acid; Hydrogen-Ion Concentration; Ligases; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Pyrimidines; Pyruvic Acid; Substrate Specificity; Thiamine Pyrophosphate

2012
Chlamydomonas reinhardtii chloroplasts contain a homodimeric pyruvate:ferredoxin oxidoreductase that functions with FDX1.
    Plant physiology, 2013, Volume: 161, Issue:1

    Topics: Acetyl Coenzyme A; Amino Acid Sequence; Benzyl Viologen; Chlamydomonas reinhardtii; Chloroplast Proteins; Chloroplasts; Electron Spin Resonance Spectroscopy; Electron Transport; Electrophoresis, Polyacrylamide Gel; Energy Metabolism; Enzyme Activation; Escherichia coli; Ferredoxins; Immunoblotting; Iron-Sulfur Proteins; Molecular Sequence Data; Oxidation-Reduction; Pyruvate Decarboxylase; Pyruvate Synthase; Pyruvic Acid; Recombinant Proteins; Solubility; Thiamine Pyrophosphate

2013
Pyruvate decarboxylase activity is regulated by the Ser/Thr protein phosphatase Sit4p in the yeast Saccharomyces cerevisiae.
    FEMS yeast research, 2013, Volume: 13, Issue:6

    Topics: Coenzymes; Gene Deletion; Gene Expression Regulation, Fungal; Kinetics; Phosphorylation; Protein Binding; Protein Phosphatase 2; Pyruvate Decarboxylase; Pyruvic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiamine Pyrophosphate

2013
Mutational analysis of critical residues of FAD-independent catabolic acetolactate synthase from Enterococcus faecalis V583.
    International journal of biological macromolecules, 2015, Volume: 72

    Topics: Acetolactate Synthase; Amino Acid Sequence; Amino Acids; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Enterococcus faecalis; Flavin-Adenine Dinucleotide; Kinetics; Molecular Docking Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyruvic Acid; Sequence Alignment; Spectrometry, Fluorescence; Structural Homology, Protein; Thiamine Pyrophosphate; Tryptophan

2015
Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation.
    Angewandte Chemie (International ed. in English), 2014, Dec-22, Volume: 53, Issue:52

    Topics: Amino Acid Substitution; Azoarcus; Benzoin; Biocatalysis; Carbon; Catalytic Domain; Cyclohexanones; Hydrolases; Pyruvic Acid; Thiamine Pyrophosphate

2014
Detailed structure-function correlations of Bacillus subtilis acetolactate synthase.
    Chembiochem : a European journal of chemical biology, 2015, Jan-02, Volume: 16, Issue:1

    Topics: Acetolactate Synthase; Aldehydes; Bacillus subtilis; Bacterial Proteins; Biocatalysis; Biofuels; Butanols; Catalytic Domain; Cations, Divalent; Coenzymes; Crystallography, X-Ray; Escherichia coli; Gene Expression; Hemiterpenes; Keto Acids; Lactates; Magnesium; Models, Molecular; Phylogeny; Point Mutation; Pyruvic Acid; Structure-Activity Relationship; Thiamine Pyrophosphate

2015
New Insights on the Reaction Pathway Leading to Lactyl-ThDP: A Theoretical Approach.
    Journal of chemical information and modeling, 2015, Aug-24, Volume: 55, Issue:8

    Topics: Acetolactate Synthase; Models, Molecular; Pyruvic Acid; Quantum Theory; Saccharomyces cerevisiae; Thermodynamics; Thiamine Pyrophosphate

2015
Crystal structure of pyruvate decarboxylase from Zymobacter palmae.
    Acta crystallographica. Section F, Structural biology communications, 2016, Volume: 72, Issue:Pt 9

    Topics: Amino Acid Sequence; Bacterial Proteins; Catalytic Domain; Cations, Divalent; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Ethylene Glycol; Gene Expression; Halomonadaceae; Kinetics; Magnesium; Models, Molecular; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Pyruvate Decarboxylase; Pyruvic Acid; Recombinant Proteins; Substrate Specificity; Thiamine Pyrophosphate

2016
A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation.
    Organic & biomolecular chemistry, 2016, Sep-21, Volume: 14, Issue:37

    Topics: Biosynthetic Pathways; Carbazoles; Genes, Bacterial; Indoles; Kinetics; Multigene Family; Phylogeny; Pyruvic Acid; Streptomyces; Thiamine Pyrophosphate

2016
Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.
    ACS infectious diseases, 2017, 07-14, Volume: 3, Issue:7

    Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Cloning, Molecular; Enzyme Inhibitors; Escherichia coli; Gene Expression; Glyceraldehyde 3-Phosphate; Microbial Sensitivity Tests; Organophosphonates; Plasmids; Pyridoxal Phosphate; Pyruvic Acid; Recombinant Proteins; Thiamine Pyrophosphate; Transferases

2017
Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens.
    Chembiochem : a European journal of chemical biology, 2018, 11-02, Volume: 19, Issue:21

    Topics: Bacterial Proteins; Benzaldehydes; Crystallography, X-Ray; Humans; Ketones; Ligases; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Pseudomonas; Pseudomonas Infections; Pyruvic Acid; Stereoisomerism; Substrate Specificity; Thiamine Pyrophosphate

2018
Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress.
    BMC microbiology, 2010, May-21, Volume: 10

    Topics: Adenosine Triphosphate; Carbon; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Culture Media; Energy Metabolism; Escherichia coli; Glucose; Lactic Acid; Pyruvic Acid; Stress, Physiological; Thiamine Triphosphate; Uncoupling Agents

2010
An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate.
    Scientific reports, 2013, Volume: 3

    Topics: Citric Acid Cycle; Escherichia coli; Mutation; Proton-Translocating ATPases; Pyruvic Acid; Thiamine Triphosphate

2013