thiamine pyrophosphate has been researched along with pyruvic acid in 94 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 41 (43.62) | 18.7374 |
1990's | 15 (15.96) | 18.2507 |
2000's | 21 (22.34) | 29.6817 |
2010's | 17 (18.09) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Hugenholtz, J; Snoep, JL; Starrenburg, MJ; Teixeira de Mattos, MJ | 1 |
Leadlay, PF; Lowe, PN; Williams, KP | 1 |
Elnageh, KM; Gaitonde, MK | 1 |
Ali, BH; Czarnecki, CM | 1 |
Gathercole, PS; Hofmeyr, JH; Thiel, PG | 1 |
Frey, PA; Gruys, KJ; Steginsky, CA | 1 |
Barron, LL; Olson, MS; Robertson, JG | 1 |
Milani, A; Neher, R | 1 |
Chen, G; Jordan, F; Nishikawa, S; Wu, BS | 1 |
Khailova, LS; Nemerya, NS; Severin, SE | 1 |
Krampitz, LO | 1 |
Frey, PA | 3 |
Kluger, R | 1 |
Hübner, G; Khailova, LS; Neef, H; Schellenberger, A; Severin, SE | 1 |
Khailova, LS; Korotchkina, LG; Severin, SE | 1 |
Chernikevich, IP; Kivach, LN; Maskevich, AA; Maskevich, SA; Oparin, DA; Zabrodskaia, SV | 1 |
Khailova, LS; Nemerya, NS; Nyukhalkina, IA; Zemskova, MA | 1 |
Menon, S; Ragsdale, SW | 2 |
Chang, AK; Duggleby, RG | 2 |
Bisswanger, H; Hennig, J; Hübner, G; Kern, G; Neef, H; Spinka, M | 1 |
Baburina, I; Furey, W; Gao, Y; Guest, JR; Guo, F; Jordan, F; Kahyaoglu, A; Li, H; Nemeria, N; Wang, J; Yi, J | 1 |
Candy, JM; Duggleby, RG | 1 |
Frontali, L; Meacock, P; Tizzani, L; Wésolowski-Louvel, M | 1 |
Korotchkina, LG; Patel, MS; Tripatara, A | 1 |
Chabriere, E; Charon, MH; Fontecilla-Camps, JC; Pieulle, L; Volbeda, A | 1 |
Baumann, S; Dobritzsch, D; König, S; Lu, G; Schneider, G | 1 |
Andersson, LA; Baker, JC; Cole, AB; Gong, X; Li, L; Liu, S; Peng, T; Ravindran, S; Robben, PM; Roche, TE; Yan, X | 1 |
Chabrière, E; Charon, MH; Fontecilla-Camps, JC; Guigliarelli, B; Hatchikian, EC; Vernède, X | 1 |
Butler, IS; Hadjiliadis, N; Louloudi, M; Vartzouma, Ch | 1 |
Jordan, F; Sergienko, E; Zhang, Z | 1 |
ARAKAWA, T | 1 |
LASCH, F | 1 |
PANSINI, R; SOZIO, N | 1 |
BREHM, G; KORTING, GW | 1 |
NAVAZIO, F; SILIPRANDI, N | 1 |
AL BERMANI, MA; GREIF, S; HOCHEGGER, M | 1 |
HUTSCHENREUTER, K | 1 |
BENDA, L; DONEFF, D; MOSER, K | 1 |
JARVINEN, PA; WIDHOLM, O | 2 |
CASELLATO, R; SCARPA, P | 1 |
GOEDDE, HW; GOEGGEL, KH; HOLZER, H; ULRICH, B | 1 |
KARDASZEWICZ, S; MASNY, N | 1 |
FERSINI, C; RIPA, R | 1 |
HOLZER, H; KOHLHAW, G; WOENCKHAUS, CW | 1 |
HOLZER, H; ULLRICH, J | 1 |
HENNING, U | 1 |
BERGQUIST, A; KIRITANI, K; NARISE, S; WAGNER, RP | 1 |
KIESSLING, KH; LUNDQUIST, CG | 2 |
PANSINI, R; RIPA, R | 1 |
Baek, DK; Choi, JD; Choi, MK; Hwang, JH; Kim, J; Kim, YT; Yoon, MY | 1 |
GILLILAND, IC; MARTIN, MM | 1 |
SURIYONG, R | 1 |
CATTANEO, R | 1 |
GRUBER, M; MEYER, FG | 1 |
de LOZE, C | 1 |
LIU, KT | 1 |
FAVACCHIO, G | 1 |
Barak, Z; Chipman, DM; Duggleby, RG; Golbik, R; Hübner, G; Kaplun, A; McCourt, J; Schröder, K; Tittmann, K | 1 |
Jordan, F; Liu, M; Yan, Y; Zhang, S; Zhang, Z | 1 |
Frank, RA; Luisi, BF; Perham, RN; Pratap, JV; Titman, CM | 1 |
Duggleby, RG; McCourt, JA | 1 |
Ghisla, S; Golbik, R; Hübner, G; Tittmann, K; Weidner, A; Wille, G | 1 |
Celik, L; Jørgensen, KA; Lie, MA; Schiøtt, B | 1 |
Cavazza, C; Chabrière, E; Contreras-Martel, C; Fontecilla-Camps, JC; Hatchikian, EC; Pieulle, L | 1 |
Golbik, R; Hinze, E; Meyer, D; Steinmetz, A; Tittmann, K; Wille, G | 1 |
Baykal, A; Chakraborty, S; Dodoo, A; Jordan, F | 1 |
Cremades, N; Croxen, MA; Harman, WD; Hoffman, PS; Morash, MG; Sisson, G; Welch, K | 1 |
Batifoulier, F; Besson, C; Chanliaud, E; Demigné, C; Rémésy, C; Verny, MA | 1 |
GRUBER, M; MEIJER, FG; MONFOORT, CH | 1 |
Tittmann, K | 1 |
Akhtar, MK; Jones, PR | 1 |
Alderete, J; Delgado, E; Jaña, G; Jiménez, V; Prat-Resina, X; Villà-Freixa, J | 1 |
Andrews, FH; McLeish, MJ | 1 |
Alvarado, O; Delgado, EJ; Jaña, G | 1 |
Balakrishnan, A; Barak, Z; Binshtein, E; Chipman, D; Jordan, F; Nemeria, N; Patel, H; Shaanan, B; Vered, I | 1 |
Atteia, A; Baffert, C; Couté, Y; Nitschke, W; van Lis, R | 1 |
de Assis, LJ; Masuda, CA; Montero-Lomelí, M; Rodrigues, SP; Zingali, RB | 1 |
Baig, IA; Chien, PN; Jung, IP; La, IJ; Lee, SC; Yoon, MY | 1 |
Andrade, SL; Giovannini, PP; Loschonsky, S; McLeish, MJ; Müller, M; Wacker, T; Waltzer, S | 1 |
Bourenkov, G; Brück, T; Garbe, D; Haack, M; Langner, C; Loll, B; Qoura, F; Sommer, B; von Moeller, H | 1 |
Delgado, EJ; Jaña, GA; Lizana, I | 1 |
Li, Y; Liu, Y; Wang, X | 1 |
Andrews, ES; Arcus, VL; Buddrus, L; Crennell, SJ; Danson, MJ; Leak, DJ | 1 |
Deng, H; Deng, Z; Kyeremeh, K; Lv, M; Su, L; Yu, Y | 1 |
Aklinski, JL; Bartee, D; DeColli, AA; Freel Meyers, CL; Harrison, MJ; Koppisch, AT; Sanders, S; Vierling, RJ | 1 |
Baierl, A; Dobritzsch, D; Fries, A; Hampel, S; Lehwald, P; Müller, M; Pohl, M; Richter, M; Schneider, G; Steitz, JP; Wiesli, L | 1 |
Bettendorff, L; El Moualij, B; Gigliobianco, T; Lakaye, B; Wins, P; Zorzi, W | 1 |
Bettendorff, L; Gangolf, M; Gigliobianco, T; Lakaye, B; Pirson, B; von Ballmoos, C; Wins, P | 1 |
8 review(s) available for thiamine pyrophosphate and pyruvic acid
Article | Year |
---|---|
Thiamin: twenty years ago.
Topics: Acetaldehyde; Acetoin; Acetolactate Synthase; Animals; Bacteria; Carbon Dioxide; Chemical Phenomena; Chemistry; Formaldehyde; Hexosephosphates; Lactates; Oxaloacetates; Pentosephosphates; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate; Transketolase | 1982 |
Mechanism of coupled electron and group transfer in Escherichia coli pyruvate dehydrogenase.
Topics: Acetyl Coenzyme A; Acetylation; Binding Sites; Chemical Phenomena; Chemistry; Coenzyme A; Electron Transport; Escherichia coli; Flavin-Adenine Dinucleotide; Molecular Weight; NAD; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Spectrophotometry; Thiamine Pyrophosphate; Thioctic Acid | 1982 |
Regulation of thiamin diphosphate-dependent 2-oxo acid decarboxylases by substrate and thiamin diphosphate.Mg(II) - evidence for tertiary and quaternary interactions.
Topics: Binding Sites; Crystallography, X-Ray; Enzyme Activation; Magnesium; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Tertiary; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thiamine Pyrophosphate | 1998 |
Structure and properties of pyruvate decarboxylase and site-directed mutagenesis of the Zymomonas mobilis enzyme.
Topics: Amino Acid Sequence; Binding Sites; Catalysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyruvate Decarboxylase; Pyruvic Acid; Thiamine Pyrophosphate; Zymomonas | 1998 |
Structure and electron transfer mechanism of pyruvate:ferredoxin oxidoreductase.
Topics: Electron Transport; Ketone Oxidoreductases; Models, Molecular; Protein Binding; Protein Conformation; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate | 1999 |
Reaction mechanisms of thiamin diphosphate enzymes: redox reactions.
Topics: Animals; Catalysis; Crystallography, X-Ray; Electron Transport; Humans; Kinetics; Models, Molecular; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvate Oxidase; Pyruvic Acid; Structure-Activity Relationship; Thiamine Pyrophosphate | 2009 |
Substrate specificity in thiamin diphosphate-dependent decarboxylases.
Topics: Acyl Coenzyme A; Bacteria; Carboxy-Lyases; Catalytic Domain; Glyoxylates; Mandelic Acids; Mutagenesis, Site-Directed; Pyruvic Acid; Saccharomyces cerevisiae; Substrate Specificity; Thiamine Pyrophosphate | 2012 |
Acetohydroxyacid synthases: evolution, structure, and function.
Topics: Acetolactate Synthase; Butyrates; Coenzymes; Evolution, Molecular; Hydroxybutyrates; Lactates; Protein Conformation; Pyruvic Acid; Thiamine Pyrophosphate | 2016 |
86 other study(ies) available for thiamine pyrophosphate and pyruvic acid
Article | Year |
---|---|
Isolation, characterization, and physiological role of the pyruvate dehydrogenase complex and alpha-acetolactate synthase of Lactococcus lactis subsp. lactis bv. diacetylactis.
Topics: Acetolactate Synthase; Cations, Divalent; Chromatography, High Pressure Liquid; Kinetics; Lactococcus lactis; NAD; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1992 |
Inhibition of pyruvate:ferredoxin oxidoreductase from Trichomonas vaginalis by pyruvate and its analogues. Comparison with the pyruvate decarboxylase component of the pyruvate dehydrogenase complex.
Topics: Animals; Binding Sites; Carboxy-Lyases; Coenzyme A; Dithiothreitol; Escherichia coli; Ketone Oxidoreductases; Kinetics; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvate Synthase; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate; Trichomonas vaginalis | 1990 |
Effect of a deficiency of thiamine on brain pyruvate dehydrogenase: enzyme assay by three different methods.
Topics: Animals; Brain; Carbon Dioxide; Coloring Agents; Enzyme Activation; Kinetics; Male; Mitochondria; NAD; Oxidation-Reduction; Pyrithiamine; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Tetrazolium Salts; Thiamine Deficiency; Thiamine Pyrophosphate | 1988 |
Ethanol-induced alteration in thiamin status of young turkey poults.
Topics: Animals; Body Weight; Erythrocytes; Ethanol; Heart; Lactates; Lactic Acid; Male; Organ Size; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate; Transketolase; Turkeys | 1987 |
Inhibition of pyruvate dehydrogenase complex by moniliformin.
Topics: Cyclobutanes; Dialysis; Kinetics; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1986 |
alpha-Ketoglutarate dehydrogenase complex of Escherichia coli. A hybrid complex containing pyruvate dehydrogenase subunits from pyruvate dehydrogenase complex.
Topics: Acetylation; Escherichia coli; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Ketone Oxidoreductases; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1985 |
Effects of alpha-ketoisovalerate on bovine heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase.
Topics: Animals; Cattle; Electrophoresis, Polyacrylamide Gel; Hemiterpenes; Keto Acids; Kinetics; Myocardium; Potassium Chloride; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Substrate Specificity; Thiamine Pyrophosphate | 1986 |
Pyruvate and thiamine pyrophosphate potentiate cyclic nucleotide-induced steroidogenesis in isolated rat adrenocortical cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Citric Acid Cycle; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Oxaloacetates; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate | 1983 |
Potential roles of the aminopyrimidine ring in thiamin catalyzed reactions.
Topics: Chemical Phenomena; Chemistry; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Oxythiamine; Protons; Pyrimidines; Pyruvates; Pyruvic Acid; Structure-Activity Relationship; Thiamine; Thiamine Pyrophosphate | 1982 |
The substrate-mediated inactivation of the pyruvate dehydrogenase component of the pigeon breast muscle pyruvate dehydrogenase complex.
Topics: Animals; Carbon Radioisotopes; Columbidae; Kinetics; Muscles; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1983 |
Reactive intermediates in thiamin catalysis.
Topics: Drug Stability; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Oxythiamine; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate | 1982 |
Effect of pyruvate and its analogs on the thiamine pyrophosphate binding in the active center of muscle pyruvate dehydrogenase.
Topics: 2,6-Dichloroindophenol; Animals; Butyrates; Chemical Phenomena; Chemistry; Columbidae; Muscles; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1982 |
The effect of phosphorylation on pyruvate dehydrogenase.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Circular Dichroism; Columbidae; In Vitro Techniques; Kinetics; Muscles; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Substrate Specificity; Thiamine Pyrophosphate | 1995 |
[Spectroscopic study of the structure and intramolecular mobility of yeast pyruvate decarboxylase].
Topics: Anilino Naphthalenesulfonates; Binding Sites; Fluorescent Dyes; Luminescent Measurements; Protein Conformation; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Sulfhydryl Reagents; Thiamine; Thiamine Pyrophosphate | 1993 |
Chemical modification of the essential arginine residues of pyruvate dehydrogenase prevents its phosphorylation by kinase.
Topics: Animals; Arginine; Binding Sites; Columbidae; Muscle, Skeletal; Phosphorylation; Phosphoserine; Protein Kinases; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thiamine Pyrophosphate | 1996 |
Unleashing hydrogenase activity in carbon monoxide dehydrogenase/acetyl-CoA synthase and pyruvate:ferredoxin oxidoreductase.
Topics: Acetyl Coenzyme A; Aldehyde Oxidoreductases; Binding Sites; Carbon Monoxide; Clostridium; Electron Transport; Hydrogen; Hydrogenase; Ketone Oxidoreductases; Kinetics; Multienzyme Complexes; Oxidation-Reduction; Paraquat; Potassium Cyanide; Protons; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate | 1996 |
Mechanism of the Clostridium thermoaceticum pyruvate:ferredoxin oxidoreductase: evidence for the common catalytic intermediacy of the hydroxyethylthiamine pyropyrosphate radical.
Topics: Clostridium; Coenzyme A; Electron Spin Resonance Spectroscopy; Free Radicals; Iron; Iron-Sulfur Proteins; Ketone Oxidoreductases; Kinetics; Molecular Structure; Oxidation-Reduction; Paraquat; Protein Binding; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate | 1997 |
Expression, purification and characterization of Arabidopsis thaliana acetohydroxyacid synthase.
Topics: Acetolactate Synthase; Arabidopsis; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Flavin-Adenine Dinucleotide; Gene Expression; Imidazoles; Kinetics; Molecular Weight; Niacin; Peptide Fragments; Pyruvic Acid; Recombinant Proteins; Sequence Analysis; Sulfonamides; Thiamine Pyrophosphate; Triazines | 1997 |
Molecular mechanism of regulation of the pyruvate dehydrogenase complex from E. coli.
Topics: Coenzymes; Diethyl Pyrocarbonate; Enzyme Activation; Escherichia coli; Kinetics; NAD; Protein Binding; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Spectrometry, Fluorescence; Thiamine Pyrophosphate; Tryptophan | 1997 |
Herbicide-resistant forms of Arabidopsis thaliana acetohydroxyacid synthase: characterization of the catalytic properties and sensitivity to inhibitors of four defined mutants.
Topics: Acetolactate Synthase; Arabidopsis; Catalysis; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Flavin-Adenine Dinucleotide; Herbicides; Hydrogen-Ion Concentration; Kinetics; Magnesium; Mutation; Pyruvic Acid; Sensitivity and Specificity; Substrate Specificity; Thiamine Pyrophosphate | 1998 |
The RAG3 gene of Kluyveromyces lactis is involved in the transcriptional regulation of genes coding for enzymes implicated in pyruvate utilization and genes of the biosynthesis of thiamine pyrophosphate.
Topics: Blotting, Northern; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Kluyveromyces; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; RNA, Bacterial; Thiamine Pyrophosphate; Transcription, Genetic | 1998 |
Characterization of point mutations in patients with pyruvate dehydrogenase deficiency: role of methionine-181, proline-188, and arginine-349 in the alpha subunit.
Topics: 2,6-Dichloroindophenol; Acetylation; Acetyltransferases; Amino Acid Substitution; Apoenzymes; Arginine; Binding Sites; Circular Dichroism; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Stability; Humans; Kinetics; Methionine; Point Mutation; Proline; Protein Structure, Secondary; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvic Acid; Recombinant Proteins; Thermodynamics; Thiamine Pyrophosphate | 1999 |
The structural basis of substrate activation in yeast pyruvate decarboxylase. A crystallographic and kinetic study.
Topics: Catalytic Domain; Crystallography, X-Ray; Enzyme Activation; Kinetics; Models, Molecular; Protein Structure, Quaternary; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae; Static Electricity; Substrate Specificity; Thiamine Pyrophosphate | 2000 |
Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
Topics: Acetylation; Acetyltransferases; Animals; Cattle; Circular Dichroism; Dihydrolipoamide Dehydrogenase; Dihydrolipoyllysine-Residue Acetyltransferase; Humans; Kinetics; Models, Molecular; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thermodynamics; Thiamine Pyrophosphate; Thioctic Acid | 2001 |
Enzymology. Coenzymes and radicals.
Topics: Catalysis; Catalytic Domain; Chemical Phenomena; Chemistry, Physical; Coenzyme A; Coenzymes; Crystallization; Crystallography, X-Ray; Electrons; Ferredoxins; Ferricyanides; Free Radicals; Ketone Oxidoreductases; Molecular Structure; Oxidation-Reduction; Protons; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate | 2001 |
Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase.
Topics: Acetyl Coenzyme A; Anaerobiosis; Binding Sites; Carbon Dioxide; Catalysis; Chemical Phenomena; Chemistry, Physical; Coenzymes; Crystallization; Crystallography, X-Ray; Desulfovibrio; Dimerization; Electron Spin Resonance Spectroscopy; Free Radicals; Ketone Oxidoreductases; Molecular Conformation; Molecular Structure; Oxidation-Reduction; Protein Conformation; Pyruvate Synthase; Pyruvic Acid; Thiamine Pyrophosphate | 2001 |
Practical tethering of vitamin B1 on a silica surface via its phosphate group and evaluation of its activity.
Topics: Catalysis; Cross-Linking Reagents; Decarboxylation; Phosphates; Pyruvate Decarboxylase; Pyruvic Acid; Silicon Dioxide; Thiamine; Thiamine Pyrophosphate | 2002 |
Spectroscopic evidence for participation of the 1',4'-imino tautomer of thiamin diphosphate in catalysis by yeast pyruvate decarboxylase.
Topics: Acetaldehyde; Binding Sites; Catalysis; Circular Dichroism; Holoenzymes; Isomerism; Models, Chemical; Models, Molecular; Protein Conformation; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Spectrum Analysis; Thiamine Pyrophosphate; Yeasts | 2002 |
The existence of co-carboxylase in human milk. Part 1. Influence of human milk upon decarboxylation of pyruvate by alkaline washed yeast carboxylase; 218th report of the peroxidase reaction.
Topics: Decarboxylation; Milk, Human; Oxidation-Reduction; Peroxidases; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1952 |
[Pyruvic acid and cocarboxylase; the importance of pyruvic acid determination in blood for clinical diagnosis and the effects of cocarboxylase on the increased pyruvic acid blood level].
Topics: Humans; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1953 |
[Research on muscle physiopathology in man. III. Variations in the endogenous blood alcohol, pyruvic acid and glucose in the venous circulation after cocarboxylase load in muscle diseases].
Topics: Blood; Blood Glucose; Disease; Ethanol; Glucose; Humans; Male; Muscles; Muscular Diseases; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate; Veins | 1953 |
[Additional studies on the pyruvic acid level in blood and skin blisters and its control by cocarboxylase and thioctin acid].
Topics: Blister; Blood; Body Fluids; Inorganic Chemicals; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate | 1955 |
The action of cocarboxylase on pyruvate utilisation and citrate formation in the liver of normal and diabetic rats.
Topics: Animals; Citrates; Citric Acid; Diabetes Mellitus, Experimental; Liver; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate | 1955 |
[Pyruvic acid & cocarboxylase in cardiac decompensation].
Topics: Heart Failure; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1957 |
[Postoperative cocarboxylase therapy by control of pyruvic acid in blood].
Topics: Humans; Postoperative Period; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1957 |
[Effect of cocarboxylase on blood pyruvic acid in cardiac decompensation and digitalis intoxication].
Topics: Cardiovascular Agents; Digitalis; Heart Failure; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1958 |
[Pyruvic acid content of blood in toxemias & hyperemesis gravidarum & the effect of cocarboxylase].
Topics: Female; Humans; Hyperemesis Gravidarum; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pyruvic Acid; Thiamine Pyrophosphate; Toxemia; Vomiting | 1958 |
Blood pyruvic acid concentration in carcinoma during radiotherapy: with especial consideration of the effect of cocarboxylase and thiamine monophosphate.
Topics: Carcinoma; Genitalia; Genitalia, Female; Neoplasms; Pyruvates; Pyruvic Acid; Radiotherapy; Thiamine Monophosphate; Thiamine Pyrophosphate | 1959 |
[Behavior of cocarboxyiase and pyruvic acid in rats subjected to various hypolipidic diets].
Topics: Animals; Diet; Lipids; Liver; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate | 1960 |
Identification of alpha-hydroxyethyl thiamine pyrophosphate ("active acetaldehyde") as an intermediate in the oxidation of pyruvate by pyruvic oxidase from yeast mitochondria.
Topics: Acetaldehyde; Mitochondria; Oxidation-Reduction; Oxidoreductases; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae; Thiamine Pyrophosphate; Yeasts | 1960 |
[Pyruvic acid level in the blood and attempted use of cocarboxylase (berolase) in circulatory insufficiency].
Topics: Heart Failure; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1961 |
[The pyruvate-ethanol changes after loading with cocarboxylase in diabetics].
Topics: Diabetes Mellitus; Ethanol; Humans; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1962 |
Active forms of acetaldehyde, pyruvate, and glycolic aldehyde.
Topics: Acetaldehyde; Aldehydes; Biochemical Phenomena; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1962 |
[THE PH FACTOR IN THE 2-(L-HYDROXY-ETHYL)-THIAMINE PYROPHOSPHATE YIELD IN THE TRANSFORMATION OF PYRUVATE WITH THIAMINE PYROPHOSPHATE TO PYRUVATE OXIDASE FROM SWINE MYOCARDIUM].
Topics: Animals; Diphosphates; Hydrogen-Ion Concentration; Myocardium; Pyruvate Oxidase; Pyruvates; Pyruvic Acid; Research; Swine; Thiamine; Thiamine Pyrophosphate | 1963 |
[A REGULATORY MECHANISM IN THE DEGRADATION OF PYRUVIC ACID BY ESCHERICHIA COLI].
Topics: Coenzyme A; Escherichia coli; Formates; Oxidoreductases; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1963 |
THE OVERALL IN VITRO SYNTHESIS OF VALINE FROM PYRUVATE BY NEUROSPORA HOMOGENATES.
Topics: Amino Acids; Calcium; Edetic Acid; Hydro-Lyases; Hydrogen-Ion Concentration; In Vitro Techniques; Isomerases; Keto Acids; Lyases; Magnesium; NAD; Neurospora; Pyruvates; Pyruvic Acid; Research; Sucrose; Thiamine Pyrophosphate; Transaminases; Valine | 1965 |
Thiamine diphosphate in growing tissues. III. Pyruvate oxidation in liver mitochondria from young and from thiamine diphosphate deficient adult rats.
Topics: Animals; Mitochondria; Mitochondria, Liver; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate | 1962 |
Thiamine diphosphate in growing tissues. IV. Pyruvate oxidation in muscle mitochondria from young rats and in mitochondria from malignant tissues.
Topics: Animals; Mitochondria; Mitochondria, Muscle; Muscles; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Thiamine Pyrophosphate | 1962 |
[The cocarboxylase test of the normal relations between endogenous arteriovenous blood alcohol and the pyruvate phase of intermediate metabolism in normal persons and patients with liver disease].
Topics: Alcohols; Biochemical Phenomena; Digestion; Humans; Liver Diseases; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1961 |
The active site and mechanism of action of recombinant acetohydroxy acid synthase from tobacco.
Topics: Acetolactate Synthase; Binding Sites; Catalysis; Ethanol; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nicotiana; Pyruvic Acid; Recombinant Proteins; Temperature; Thermodynamics; Thiamine Pyrophosphate; Water | 2003 |
Raised blood pyruvic acid level in diabetic acidosis; the value of cocarboxylase in treatment.
Topics: Diabetes Mellitus; Diabetic Ketoacidosis; Pyruvic Acid; Thiamine Pyrophosphate | 1951 |
[Clinical investigations on the action of cocarboxylase].
Topics: Blood; Pyruvic Acid; Sjogren's Syndrome; Thiamine; Thiamine Pyrophosphate | 1950 |
[Thiamine, cocarboxylase and pyruvic acid metabolism in liver disease after glucose load].
Topics: Blood; Glucose; Humans; Liver Diseases; Pyruvic Acid; Thiamine; Thiamine Pyrophosphate | 1951 |
A study of the influence of thiamine and thiamine pyrophosphate on the anaerobic pyruvate metabolism of pig heart muscle.
Topics: Animals; Biochemical Phenomena; Myocardium; Pyruvic Acid; Sus scrofa; Swine; Thiamine; Thiamine Pyrophosphate | 1951 |
[The ultraviolet spectra of aneurin and cocarboxylase in the presence of the ethyl pyruvate and mixture of acetaldehyde and pyruvic acid].
Topics: Acetaldehyde; Pyruvates; Pyruvic Acid; Spectrum Analysis; Thiamine; Thiamine Pyrophosphate | 1951 |
[Effect of previous or simultaneous application of cocarboxylase, ribonuclease, pyruvic acid and quinine on the response of the isolated frog heart to convallatoxin].
Topics: Animals; Anura; Cardiac Glycosides; Heart; Pyruvic Acid; Quinine; Ribonucleases; Strophanthins; Thiamine Pyrophosphate | 1951 |
[Amount of pyruvic acid in blood of surgical subjects with pentothal-curare-ether narcosis and the action of co-carboxylase].
Topics: Carboxy-Lyases; Curare; Ether; Ethers; Humans; Pyruvates; Pyruvic Acid; Stupor; Thiamine Pyrophosphate; Thiopental | 1952 |
Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme.
Topics: Acetolactate Synthase; Catalysis; Electron Transport; Flavin-Adenine Dinucleotide; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Oxygen; Pyruvic Acid; Spectrum Analysis; Thiamine Pyrophosphate | 2004 |
C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models.
Topics: Acetaldehyde; Decarboxylation; Diphosphates; Escherichia coli; Furans; Kinetics; Molecular Conformation; Oxythiamine; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Saccharomyces cerevisiae; Thiamine Pyrophosphate | 2004 |
A molecular switch and proton wire synchronize the active sites in thiamine enzymes.
Topics: Amino Acid Substitution; Binding Sites; Catalysis; Crystallography, X-Ray; Dihydrolipoyllysine-Residue Acetyltransferase; Geobacillus stearothermophilus; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Mutation; Phosphorylation; Protein Conformation; Protein Folding; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein Subunits; Protons; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thiamine Pyrophosphate | 2004 |
How an enzyme answers multiple-choice questions.
Topics: Acetolactate Synthase; Molecular Structure; Pyruvic Acid; Substrate Specificity; Thiamine Pyrophosphate | 2005 |
Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum. Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FA
Topics: Catalysis; Electrons; Flavin-Adenine Dinucleotide; Flavins; Fluorescence Resonance Energy Transfer; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Lactobacillus plantarum; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Statistical; Oxidation-Reduction; Oxygen; Phosphates; Pyruvate Oxidase; Pyruvic Acid; Solvents; Spectrophotometry; Temperature; Thermodynamics; Thiamine Pyrophosphate; Time Factors | 2005 |
Cofactor activation and substrate binding in pyruvate decarboxylase. Insights into the reaction mechanism from molecular dynamics simulations.
Topics: Binding Sites; Catalytic Domain; Computer Simulation; Hydrogen Bonding; Models, Chemical; Models, Molecular; Mutation; Pyruvate Decarboxylase; Pyruvic Acid; Thiamine Pyrophosphate; Zymomonas | 2005 |
Flexibility of thiamine diphosphate revealed by kinetic crystallographic studies of the reaction of pyruvate-ferredoxin oxidoreductase with pyruvate.
Topics: Anaerobiosis; Crystallography, X-Ray; Kinetics; Models, Molecular; Motion; Oxygen; Pyruvate Synthase; Pyruvic Acid; Structural Homology, Protein; Thiamine Pyrophosphate; Transketolase | 2006 |
The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Topics: Binding Sites; Catalysis; Crystallography; Crystallography, X-Ray; Enzyme Activation; Lactobacillus plantarum; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Pyruvate Oxidase; Pyruvic Acid; Reference Standards; Structure-Activity Relationship; Thiamine Pyrophosphate | 2006 |
Snapshots of three intermediates at the active site of pyruvate oxidase.
Topics: Binding Sites; Crystallography; Crystallography, X-Ray; Enzyme Activation; Molecular Conformation; Pyruvate Oxidase; Pyruvic Acid; Structure-Activity Relationship; Thiamine Pyrophosphate | 2006 |
Synthesis with good enantiomeric excess of both enantiomers of alpha-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases.
Topics: Acetone; Binding Sites; Carboxy-Lyases; Escherichia coli Proteins; Ketone Oxidoreductases; Ketones; Lactates; Mutation, Missense; Pyruvate Decarboxylase; Pyruvic Acid; Saccharomyces cerevisiae Proteins; Stereoisomerism; Thiamine Pyrophosphate | 2006 |
Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.
Topics: Acetyl Coenzyme A; Animals; Antiprotozoal Agents; Bacteria, Anaerobic; Campylobacter jejuni; Carbon Dioxide; Cloning, Molecular; Clostridium; Culture Media; Enzyme Inhibitors; Helicobacter pylori; Kinetics; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Nitro Compounds; Parasites; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Reverse Transcriptase Polymerase Chain Reaction; Thiamine Pyrophosphate; Thiazoles | 2007 |
Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model.
Topics: Animals; Body Weight; Bread; Cerebellum; Diet; Disease Models, Animal; Glucose; Glutamic Acid; Kidney; Lactic Acid; Liver; Pyruvic Acid; Rats; Rats, Wistar; Thiamine; Thiamine Deficiency; Thiamine Pyrophosphate; Triticum | 2007 |
Influence of aneurin and aneurin pyrophosphate on anaerobic pyruvate metabolism of pig heart muscle in vitro.
Topics: Animals; Diphosphates; In Vitro Techniques; Myocardium; Pyruvic Acid; Sus scrofa; Swine; Thiamine; Thiamine Pyrophosphate | 1949 |
Construction of a synthetic YdbK-dependent pyruvate:H2 pathway in Escherichia coli BL21(DE3).
Topics: Bacillus subtilis; Bacterial Proteins; Clostridium; Clostridium acetobutylicum; Escherichia coli; Escherichia coli Proteins; Ferredoxins; Hydrogen; Metabolic Networks and Pathways; Models, Biological; Pyruvic Acid; Thiamine Pyrophosphate; Transcription Factors | 2009 |
Computational study on the carboligation reaction of acetohidroxyacid synthase: new approach on the role of the HEThDP- intermediate.
Topics: Acetolactate Synthase; Amino Acids; Catalytic Domain; Fungal Proteins; Lactates; Molecular Dynamics Simulation; Pyruvic Acid; Thermodynamics; Thiamine Pyrophosphate; Yeasts | 2010 |
Computer-assisted study on the reaction between pyruvate and ylide in the pathway leading to lactyl-ThDP.
Topics: Binding Sites; Catalysis; Computer Simulation; Models, Chemical; Pyruvic Acid; Thermodynamics; Thiamine Pyrophosphate | 2012 |
Glyoxylate carboligase: a unique thiamin diphosphate-dependent enzyme that can cycle between the 4'-aminopyrimidinium and 1',4'-iminopyrimidine tautomeric forms in the absence of the conserved glutamate.
Topics: Amino Acid Substitution; Circular Dichroism; Gene Expression Regulation; Glutamic Acid; Hydrogen-Ion Concentration; Ligases; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Pyrimidines; Pyruvic Acid; Substrate Specificity; Thiamine Pyrophosphate | 2012 |
Chlamydomonas reinhardtii chloroplasts contain a homodimeric pyruvate:ferredoxin oxidoreductase that functions with FDX1.
Topics: Acetyl Coenzyme A; Amino Acid Sequence; Benzyl Viologen; Chlamydomonas reinhardtii; Chloroplast Proteins; Chloroplasts; Electron Spin Resonance Spectroscopy; Electron Transport; Electrophoresis, Polyacrylamide Gel; Energy Metabolism; Enzyme Activation; Escherichia coli; Ferredoxins; Immunoblotting; Iron-Sulfur Proteins; Molecular Sequence Data; Oxidation-Reduction; Pyruvate Decarboxylase; Pyruvate Synthase; Pyruvic Acid; Recombinant Proteins; Solubility; Thiamine Pyrophosphate | 2013 |
Pyruvate decarboxylase activity is regulated by the Ser/Thr protein phosphatase Sit4p in the yeast Saccharomyces cerevisiae.
Topics: Coenzymes; Gene Deletion; Gene Expression Regulation, Fungal; Kinetics; Phosphorylation; Protein Binding; Protein Phosphatase 2; Pyruvate Decarboxylase; Pyruvic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiamine Pyrophosphate | 2013 |
Mutational analysis of critical residues of FAD-independent catabolic acetolactate synthase from Enterococcus faecalis V583.
Topics: Acetolactate Synthase; Amino Acid Sequence; Amino Acids; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Enterococcus faecalis; Flavin-Adenine Dinucleotide; Kinetics; Molecular Docking Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyruvic Acid; Sequence Alignment; Spectrometry, Fluorescence; Structural Homology, Protein; Thiamine Pyrophosphate; Tryptophan | 2015 |
Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation.
Topics: Amino Acid Substitution; Azoarcus; Benzoin; Biocatalysis; Carbon; Catalytic Domain; Cyclohexanones; Hydrolases; Pyruvic Acid; Thiamine Pyrophosphate | 2014 |
Detailed structure-function correlations of Bacillus subtilis acetolactate synthase.
Topics: Acetolactate Synthase; Aldehydes; Bacillus subtilis; Bacterial Proteins; Biocatalysis; Biofuels; Butanols; Catalytic Domain; Cations, Divalent; Coenzymes; Crystallography, X-Ray; Escherichia coli; Gene Expression; Hemiterpenes; Keto Acids; Lactates; Magnesium; Models, Molecular; Phylogeny; Point Mutation; Pyruvic Acid; Structure-Activity Relationship; Thiamine Pyrophosphate | 2015 |
New Insights on the Reaction Pathway Leading to Lactyl-ThDP: A Theoretical Approach.
Topics: Acetolactate Synthase; Models, Molecular; Pyruvic Acid; Quantum Theory; Saccharomyces cerevisiae; Thermodynamics; Thiamine Pyrophosphate | 2015 |
Crystal structure of pyruvate decarboxylase from Zymobacter palmae.
Topics: Amino Acid Sequence; Bacterial Proteins; Catalytic Domain; Cations, Divalent; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Ethylene Glycol; Gene Expression; Halomonadaceae; Kinetics; Magnesium; Models, Molecular; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Pyruvate Decarboxylase; Pyruvic Acid; Recombinant Proteins; Substrate Specificity; Thiamine Pyrophosphate | 2016 |
A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation.
Topics: Biosynthetic Pathways; Carbazoles; Genes, Bacterial; Indoles; Kinetics; Multigene Family; Phylogeny; Pyruvic Acid; Streptomyces; Thiamine Pyrophosphate | 2016 |
Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.
Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Cloning, Molecular; Enzyme Inhibitors; Escherichia coli; Gene Expression; Glyceraldehyde 3-Phosphate; Microbial Sensitivity Tests; Organophosphonates; Plasmids; Pyridoxal Phosphate; Pyruvic Acid; Recombinant Proteins; Thiamine Pyrophosphate; Transferases | 2017 |
Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens.
Topics: Bacterial Proteins; Benzaldehydes; Crystallography, X-Ray; Humans; Ketones; Ligases; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Pseudomonas; Pseudomonas Infections; Pyruvic Acid; Stereoisomerism; Substrate Specificity; Thiamine Pyrophosphate | 2018 |
Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress.
Topics: Adenosine Triphosphate; Carbon; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Culture Media; Energy Metabolism; Escherichia coli; Glucose; Lactic Acid; Pyruvic Acid; Stress, Physiological; Thiamine Triphosphate; Uncoupling Agents | 2010 |
An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate.
Topics: Citric Acid Cycle; Escherichia coli; Mutation; Proton-Translocating ATPases; Pyruvic Acid; Thiamine Triphosphate | 2013 |