thermozymocidin and octenidine

thermozymocidin has been researched along with octenidine* in 1 studies

Other Studies

1 other study(ies) available for thermozymocidin and octenidine

ArticleYear
Synthetic antimicrobial peptides of the halictines family disturb the membrane integrity of Candida cells.
    Biochimica et biophysica acta. Biomembranes, 2017, Volume: 1859, Issue:10

    We compared the potency of four derivatives of the antimicrobial peptide halictine-2 against six Candida species. Observed activity was peptide and species specific. Halictines rapidly permeabilized cell membranes and caused the leakage of cytosolic components. Their killing potential was enhanced by the commercial antimicrobial agent octenidine dihydrochloride. The effect on C. glabrata cells did not depend on the activity of Cdr pumps, but was influenced by their lipid composition. The pre-treatment of cells with myriocin, an inhibitor of sphingolipid synthesis, enhanced the peptides' activity, whereas pre-treatment with terbinafine and fluconazole, inhibitors of sterol synthesis, significantly weakened their efficacy. The killing efficacy of peptides increased in combination with amphotericin B. Thus the mode of action of halictines is likely to depend on the plasma-membrane sterols, which might explain the observed differences among the tested Candida species.

    Topics: Amphotericin B; Anti-Infective Agents; Antifungal Agents; Candida; Cell Membrane; Fatty Acids, Monounsaturated; Fluconazole; Imines; Lipids; Microbial Sensitivity Tests; Naphthalenes; Peptides; Pyridines; Sterols; Terbinafine

2017