theophylline has been researched along with warfarin in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (31.96) | 18.7374 |
| 1990's | 26 (26.80) | 18.2507 |
| 2000's | 26 (26.80) | 29.6817 |
| 2010's | 13 (13.40) | 24.3611 |
| 2020's | 1 (1.03) | 2.80 |
| Authors | Studies |
|---|---|
| Gubernator, K; Kansy, M; Senner, F | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Caron, G; Ermondi, G | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Chreifi, G; Do, HT; Li, H; Poulos, TL; Silverman, RB; Wang, HY | 1 |
| Furutani, Y; Hamada, M; Shimada, M; Takeuchi, T; Umezawa, H | 1 |
| Dora, E; Kovách, AG | 1 |
| Katano, Y; Nakagawa, Y; Nakazawa, M; Takeda, K; Tsukada, T | 1 |
| Best, DJ; Griffiths, DA; Jezequel, SG | 1 |
| Carey, D; Lee, HS; Tett, S | 1 |
| Foster, TS | 1 |
| Humphries, TJ | 1 |
| Lønning, PE | 1 |
| Barbey, JT; Schwartz, SL; Siddoway, LA; Woosley, RL | 1 |
| Besenfelder, E; Fuhr, U; Harder, S; Neubert, P; Neugebauer, G; Staib, AH; Wittenbrink-Dix, AM; Woelke-Seidl, E | 1 |
| Frank, WO | 1 |
| Raasch, RH | 1 |
| Kvinssland, S; Lønning, PE; Ueland, PM | 1 |
| Dejana, E; Gorio, A; Prosdocimi, M; Zanetti, A; Zatta, A | 1 |
| Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 2 |
| Altman, H; Howrie, DL; Maroon, TJ; Zitelli, BJ | 1 |
| Brouwer, KR; Cook, J; Gwilt, PR; Steinke, M | 1 |
| Chapron, DJ; Gomolin, IH; Luhan, PA | 1 |
| Jatlow, P | 1 |
| Junge-Hülsing, G; Schmitt, G; Wagner, H | 1 |
| Dietmann, K; Juhran, W; Schaumann, W; Voss, EM | 1 |
| Klein, K | 1 |
| Friedman, S; Golan, A; Goldman, J; Shoenfeld, A | 1 |
| Grün, D; Grün, G; Hirche, H; Langohr, HD; Wacker, U | 1 |
| Jacobs, MH; Senior, RM | 1 |
| Holtermann, W; Lochner, W | 1 |
| Nitz, RE; Scholtholt, J; Schraven, E | 1 |
| Furuta, K | 1 |
| Bodem, G; Dengler, HJ; Ochs, H | 1 |
| Vahlensieck, W | 1 |
| Guttman, DE; Meyer, MC | 1 |
| Akdeniz, H | 1 |
| Mahr, H | 1 |
| Luczynska, C; Wilson, K | 1 |
| Dateno, B; Kendal, AP; Meissner, MK; Patriarca, PA; Stricof, RL; Weber, JA | 1 |
| Babb, RR | 1 |
| Aarons, L; Davis, JD; Houston, JB | 1 |
| Bliesath, H; Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW; Wurst, W; Zech, K | 1 |
| Jankel, CA; Martin, BC; McMillan, JA | 1 |
| Angrisani, M; Cazzola, M; Loffreda, A; Matera, MG; Rossi, F | 1 |
| Felstead, S | 1 |
| Bopp, BA; Kukulka, MJ; Machinist, JM | 1 |
| Kunze, KL; Rettie, AE; Storch, E; Trager, WF; Wienkers, LC; Wurden, CJ | 1 |
| Binkley, SN; Ring, BJ; VandenBranden, M; Wrighton, SA | 1 |
| Fitzgerald, K; Koch, KM; Mills, JG; Sirgo, MA; Webster, C; Wood, JR | 1 |
| Lau, R | 1 |
| Dong, MS; Gillam, EM; Guengerich, FP; Johnson, WW; Shimada, T; Yamazaki, H | 1 |
| Jones, BC; Smith, DA; Tyman, CA | 1 |
| Blum, B; Bramer, SL; Efthymiopoulos, C; Maroli, A | 1 |
| Ammar, HO; el-Nahhas, SA; Ghorab, M; Makram, TS | 1 |
| Humphreys, WG; Morrison, RA; Obermeier, MT | 1 |
| Shimada, T; Yamazaki, H | 1 |
| Fask, A; Saltiel, E | 1 |
| Feely, J; Kelly, A; Williams, D | 1 |
| Langkilde, FW; Taylor, LS | 1 |
| Dorne, JL; Renwick, AG; Walton, K | 1 |
| Abel, R; Alvey, CW; Bron, NJ; Hounslow, NJ; Koup, JR; Randinitis, EJ; Rausch, G; Sedman, AJ; Vassos, AB | 1 |
| Johnston, A; Lewis, Y; Murphy, M; Warrington, SJ | 1 |
| Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A | 1 |
| Arlett, P; Bergquist, C; Gerden, B; Henderson, L; Yue, QY | 1 |
| Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI | 1 |
| Faulkner, MA; Lenz, NJ; Lenz, TL | 1 |
| Gottesdiener, KM; Kari, PP; Marbury, T; Miller, JL; Mistry, GC; Rodrigues, AD; Simpson, RC; Wagner, JA; Winchell, GA | 1 |
| Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M | 1 |
| Galeffi, C; Nicoletti, M; Palazzino, G; Rakotondramanana, DA; Ramanitrahasimbola, D; Randriantsoa, A; Rasoanaivo, P; Ratsimamanga, S | 1 |
| Kitano, F; Terasawa, H | 1 |
| Gagne, JJ; Maio, V; Rabinowitz, C | 1 |
| Abrahamyan, H; Gabrielyan, E; Hovhannisyan, A; Panossian, A; Wikman, G | 1 |
| Gunawardhana, L; Lee, RD; Mulford, D; Vakily, M; Wu, J | 1 |
| Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM | 1 |
| Capuano, A; Clementi, E; Pellegrino, P; Radice, S | 1 |
| Devarajegowda, HC; Hosamani, KM; Joshi, SD; Kurjogi, MM; Mangasuli, SN | 1 |
| Miura, T; Murayama, N; Shimizu, M; Suemizu, H; Uehara, S; Yamazaki, H | 1 |
12 review(s) available for theophylline and warfarin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole.
Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin | 1991 |
Clinical pharmacokinetics of moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin | 1990 |
Safety: cimetidine and concomitant theophylline or warfarin--drug interactions and their implications.
Topics: Adolescent; Adult; Aged; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Kinetics; Male; Middle Aged; Theophylline; Warfarin | 1986 |
The clinical significance of the effects of cigarette smoking on drug disposition.
Topics: Acetaminophen; Antipyrine; Benzodiazepines; Chlorpromazine; Clomipramine; Codeine; Humans; Pharmaceutical Preparations; Phenacetin; Propranolol; Smoking; Theophylline; Warfarin | 1983 |
Lack of pantoprazole drug interactions in man.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin | 1994 |
The safety of ranitidine in over a decade of use.
Topics: Anti-Ulcer Agents; Clinical Trials as Topic; Databases, Factual; Drug Interactions; Ethanol; Heartburn; Histamine H2 Antagonists; Humans; Product Surveillance, Postmarketing; Ranitidine; Theophylline; Triazolam; Warfarin | 1997 |
Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.
Topics: Adult; Aged; Area Under Curve; Caffeine; Child; Cytochrome P-450 CYP1A2; Humans; Infant, Newborn; Models, Biological; Pharmacokinetics; Probability; Reproducibility of Results; Risk Assessment; Substrate Specificity; Theobromine; Theophylline; Warfarin | 2001 |
St John's wort (Hypericum perforatum): drug interactions and clinical outcomes.
Topics: Contraceptives, Oral; Cyclosporine; Digoxin; Drug Interactions; Herb-Drug Interactions; HIV Protease Inhibitors; Humans; Hypericum; Plant Extracts; Selective Serotonin Reuptake Inhibitors; Theophylline; Warfarin | 2002 |
Potential interactions between exercise and drug therapy.
Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Aspirin; Digoxin; Doxycycline; Exercise; Humans; Insulin; Pharmacokinetics; Theophylline; Tissue Distribution; Verapamil; Warfarin | 2004 |
[Deadly drug interactions].
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Phenytoin; Quinolines; Theophylline; Warfarin | 2007 |
Can vaccines interact with drug metabolism?
Topics: Animals; Anticonvulsants; Cytokines; Drug Interactions; Humans; Pharmaceutical Preparations; Theophylline; Vaccines; Warfarin | 2015 |
10 trial(s) available for theophylline and warfarin
| Article | Year |
|---|---|
Clinical pharmacokinetics of moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin | 1990 |
Study of potential kinetic interactions of picumast dihydrochloride and theophylline in vitro and after oral administration in man.
Topics: Adult; Binding, Competitive; Coumarins; Drug Interactions; Histamine H1 Antagonists; Humans; Male; Middle Aged; Protein Binding; Theophylline | 1989 |
[Bioavailability of digoxin in fixed combinations (author's transl)].
Topics: Administration, Oral; Adult; Amines; Analysis of Variance; Coumarins; Digoxin; Drug Combinations; Esters; Ethers; Female; Glycolates; Humans; Ketones; Male; Radioimmunoassay; Theobromine; Theophylline; Time Factors | 1974 |
Lack of pantoprazole drug interactions in man.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin | 1994 |
Drug interactions with zileuton.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Bronchodilator Agents; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Theophylline; Warfarin | 1997 |
Theophylline and warfarin interaction studies with grepafloxacin.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Piperazines; Quinolones; Single-Blind Method; Theophylline; Warfarin | 1997 |
Drug interactions with clinafloxacin.
Topics: Adult; Aged; Anti-Infective Agents; Anticonvulsants; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Middle Aged; Phenytoin; Theophylline; Warfarin | 2001 |
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline | 2005 |
Drug interaction studies with dexlansoprazole modified release (TAK-390MR), a proton pump inhibitor with a dual delayed-release formulation: results of four randomized, double-blind, crossover, placebo-controlled, single-centre studies.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anticoagulants; Anticonvulsants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bronchodilator Agents; Cross-Over Studies; Delayed-Action Preparations; Dexlansoprazole; Diazepam; Double-Blind Method; Drug Interactions; Female; Humans; Lansoprazole; Male; Middle Aged; Phenytoin; Proton Pump Inhibitors; Theophylline; Warfarin; Young Adult | 2009 |
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult | 2014 |
77 other study(ies) available for theophylline and warfarin
| Article | Year |
|---|---|
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Topics: Aminopyridines; Animals; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Fluorobenzenes; Humans; Mice; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Structure-Activity Relationship; Swine; Theophylline; Verapamil | 2017 |
Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Actinomyces; Animals; Brain; Coumarins; Papaverine; Phosphodiesterase Inhibitors; Rabbits; Theophylline | 1975 |
Effect of proxyphylline and benzopyrones on the cerebrocortical NAD/NADH redox state and reflectance in haemorrhagic shock.
Topics: Animals; Blood Pressure; Brain; Cats; Coumarins; Drug Combinations; Electric Stimulation; Fluorometry; NAD; Nitrogen; Oxidation-Reduction; Shock, Hemorrhagic; Theophylline | 1978 |
Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture (theoesberiven) on the heart and the coronary circulation.
Topics: Adenosine; Aminophylline; Animals; Blood Volume; Cardiac Output; Coronary Circulation; Coumarins; Dogs; Dose-Response Relationship, Drug; Drug Combinations; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Oxygen; Oxygen Consumption; Plant Extracts; Rutin; Stimulation, Chemical; Theophylline | 1977 |
The screening of selected microorganisms for use as models of mammalian drug metabolism.
Topics: Animals; Diazepam; Fungi; In Vitro Techniques; Male; Microsomes, Liver; Models, Biological; Pharmaceutical Preparations; Rats; Streptomyces; Testosterone; Theophylline; Warfarin | 1991 |
Drug interactions with fluconazole.
Topics: Cross-Sectional Studies; Cyclosporine; Drug Interactions; Fluconazole; Humans; Phenytoin; Theophylline; Warfarin | 1992 |
Drug product selection--Part 4: Selecting therapeutically equivalent products: special cases.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Digitalis Glycosides; Drug Therapy; Estrogens, Conjugated (USP); Female; Humans; Theophylline; Therapeutic Equivalency; Thyroxine; Warfarin | 1991 |
Aminoglutethimide enzyme induction: pharmacological and endocrinological implications.
Topics: Aminoglutethimide; Antipyrine; Aromatase Inhibitors; Breast Neoplasms; Digitoxin; Drug Interactions; Estrogens; Humans; Theophylline; Warfarin | 1990 |
Interactions of oral antibiotics and common chronic medications.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Allopurinol; Ampicillin; Antacids; Anti-Bacterial Agents; Anticonvulsants; Carbamazepine; Digoxin; Drug Combinations; Drug Interactions; Erythromycin; Humans; Sulfamethoxazole; Sulfonamides; Sulfonylurea Compounds; Tetracycline; Theophylline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Warfarin | 1987 |
Aminoglutethimide as an inducer of microsomal enzymes. Part 1: Pharmacological aspects.
Topics: Aminoglutethimide; Antipyrine; Dexamethasone; Digitoxin; Drug Interactions; Enzyme Activation; Humans; Kinetics; Medroxyprogesterone; Medroxyprogesterone Acetate; Microsomes; Theophylline; Warfarin | 1986 |
Action of AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonylmet hox y coumarin) on human platelets in vitro.
Topics: Anticoagulants; beta-Thromboglobulin; Blood Platelets; Blood Proteins; Chromonar; Coumarins; Cyclic AMP; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Factor 4; Theophylline; Thromboxane B2 | 1986 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. I.
Topics: Animals; Antipyrine; Liver; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Models, Biological; Pharmaceutical Preparations; Phenytoin; Rats; Rats, Inbred Strains; Theophylline; Valproic Acid; Warfarin | 1988 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
Erythromycin-induced drug interactions. An illustrative case and review of the literature.
Topics: Carbamazepine; Child; Cyclosporins; Digoxin; Drug Interactions; Erythromycin; Female; Humans; Metabolic Clearance Rate; Theophylline; Warfarin | 1987 |
Computerized drug therapy: application of the hand-held microcomputer to dosage regimen design.
Topics: Computers; Digoxin; Female; Gentamicins; Humans; Male; Microcomputers; Middle Aged; Pharmaceutical Preparations; Phenytoin; Software; Theophylline; Warfarin | 1985 |
Lack of effect of influenza vaccine on theophylline levels and warfarin anticoagulation in the elderly.
Topics: Aged; Analysis of Variance; Blood Coagulation; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; Influenza Vaccines; Institutionalization; Male; Partial Thromboplastin Time; Prospective Studies; Prothrombin Time; Theophylline; Warfarin | 1985 |
Ultraviolet spectrophotometric analysis of barbiturates: evaluation of potential interferences.
Topics: Acetaminophen; Barbiturates; Chlorothiazide; Chlorpropamide; Dicumarol; Humans; Methods; Nicotinic Acids; Oxyphenbutazone; Phenacetin; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Salicylates; Spectrophotometry, Ultraviolet; Sulfamethoxazole; Sulfinpyrazone; Sulfisoxazole; Theobromine; Theophylline; Warfarin | 1973 |
[On the effect of various cardiac drugs on the connective tissue].
Topics: Animals; Benzoates; Connective Tissue; Coumarins; Dipyridamole; Glycolates; Glycosaminoglycans; Granulation Tissue; Heart; Histological Techniques; Male; Myocardium; Nicotinic Acids; Prenylamine; Propranolol; Rats; Stimulation, Chemical; Sulfur Isotopes; Sympatholytics; Theophylline; Vasodilator Agents; Verapamil | 1967 |
Pharmacological effects on coronary reactive hyperemia in conscious dogs.
Topics: Animals; Coronary Disease; Coronary Vessels; Coumarins; Dipyridamole; Dogs; Drug Synergism; Glycolates; Hyperemia; Hypoxia; Nucleosides; Piperazines; Procaine; Regional Blood Flow; Theophylline; Time Factors; Vasodilator Agents | 1971 |
[New aspects in the therapy of cerebrovascular diseases. Hemodynamic studies with a combination of coumarin-rutin-theophylline].
Topics: Adult; Aged; Blood Pressure; Carotid Arteries; Cerebrovascular Disorders; Coumarins; Drug Combinations; Hemodynamics; Humans; Intracranial Arteriosclerosis; Intracranial Arteriovenous Malformations; Middle Aged; Pulse; Rutin; Theophylline | 1974 |
Acute opthalmologic complications during the use of oral contraceptives.
Topics: Adult; Amino Alcohols; Arterial Occlusive Diseases; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Drug Combinations; Ethinyl Estradiol; Ethynodiol Diacetate; Female; Humans; Mestranol; Nicotinic Acids; Norethindrone; Retinal Artery; Theophylline; Vision Disorders; Warfarin | 1974 |
The effect of carbocromen and dipyridamole on blood flow of the gastrocnemius of the dog.
Topics: Acetylcholine; Adenosine; Aminophylline; Animals; Blood Pressure; Coumarins; Diethylamines; Dipyridamole; Dogs; Electric Stimulation; Female; Glycolates; Injections, Intra-Arterial; Injections, Intravenous; Isoproterenol; Male; Muscles; Papaverine; Regional Blood Flow; Theophylline; Vasodilator Agents | 1974 |
Theophylline toxicity due to impaired theophylline degradation.
Topics: Administration, Oral; Aged; Electrocardiography; Humans; Lung Diseases, Obstructive; Male; Oxygen Inhalation Therapy; Physical Therapy Modalities; Positive-Pressure Respiration; Radiography; Tetracycline; Theophylline; Warfarin | 1974 |
Effects of nitroglycerin, dipyridamole, carbocromen, xanthinol nicotinate, and butallylonal on venous return.
Topics: Allyl Compounds; Animals; Barbiturates; Blood Circulation; Blood Pressure; Cardiac Output; Coronary Circulation; Coronary Vessels; Coumarins; Dipyridamole; Dogs; Glycolates; Heart; Hemodynamics; Nicotinic Acids; Nitroglycerin; Theophylline; Vascular Resistance; Vasodilator Agents; Veins | 1972 |
On the mechanism of the antagonistic action of xanthine derivatives against adenosine and coronary vasodilators.
Topics: Acetamides; Adenosine; Animals; Blood Flow Velocity; Caffeine; Cell Membrane Permeability; Coronary Vessels; Coumarins; Dipyridamole; Dogs; Drug Interactions; Erythrocytes; Female; Glycolates; Humans; Male; Piperazines; Receptors, Drug; Structure-Activity Relationship; Theophylline; Vasodilator Agents; Xanthines; Xylenes | 1972 |
[Clinical-pathological investigation on retinal and cerebral hemodynamics].
Topics: Adolescent; Adult; Age Factors; Aged; Amino Alcohols; Benzoates; Blood Pressure; Blood Volume; Cerebrovascular Circulation; Coumarins; Diabetes Mellitus; Drug Combinations; Female; Fundus Oculi; Hemodynamics; Humans; Hypertension; Intracranial Arteriosclerosis; Male; Middle Aged; Oils; Papaverine; Propylamines; Regional Blood Flow; Resins, Plant; Retinal Vessels; Sympathomimetics; Theophylline; Vascular Resistance | 1972 |
[Preservation of kidney transplants].
Topics: Adrenal Cortex Hormones; Animals; Bicarbonates; Buffers; Coumarins; Dogs; Humans; Hyperbaric Oxygenation; Hypothermia, Induced; Ischemia; Isotonic Solutions; Kidney; Kidney Transplantation; Mannitol; Nicotinic Acids; Procaine; Sodium; Theophylline; Time Factors; Tissue Preservation; Transplantation, Homologous | 1968 |
Dynamic dialysis as a method for studying protein binding. II. Evaluation of the method with a number of binding systems.
Topics: Caffeine; Coloring Agents; Dialysis; Hydrogen-Ion Concentration; Kinetics; Methods; Protein Binding; Serum Albumin, Bovine; Spectrophotometry; Theophylline; Warfarin | 1970 |
[Oscillographic results of the treatment of peripheral circulatory disorders with Theo-Esberiven].
Topics: Blood Circulation; Coumarins; Extremities; Flavonoids; Humans; Oscillometry; Theophylline; Vascular Diseases | 1970 |
[Therapy of venous and arterious circulation disorders using Melilotus].
Topics: Arteriosclerosis Obliterans; Coumarins; Humans; Oils; Plant Extracts; Resins, Plant; Rutin; Theophylline; Thrombophlebitis | 1971 |
Influenza vaccination and warfarin or theophylline toxicity in nursing-home residents.
Topics: Aged; Epistaxis; Female; Hematuria; Humans; Influenza Vaccines; Nursing Homes; Theophylline; Warfarin | 1983 |
Drug interactions with cimetidine.
Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin | 1981 |
Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes.
Topics: Animals; Anti-Infective Agents; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Enoxacin; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Xanthines | 1995 |
Effect of drug interactions on outcomes of patients receiving warfarin or theophylline.
Topics: Adult; Aged; Aged, 80 and over; Clinical Laboratory Techniques; Costs and Cost Analysis; Drug Interactions; Female; Humans; Length of Stay; Male; Middle Aged; Prothrombin Time; Regression Analysis; Risk; Theophylline; Treatment Outcome; Warfarin | 1994 |
Teicoplanin with other drugs: possible pharmacological interactions.
Topics: Animals; Drug Interactions; Female; Glyburide; Hypoglycemic Agents; Male; Phenformin; Rabbits; Rats; Teicoplanin; Theophylline; Warfarin | 1993 |
Azithromycin drug interactions.
Topics: Anti-Bacterial Agents; Azithromycin; Carbamazepine; Digoxin; Drug Interactions; Ergotamine; In Vitro Techniques; Methylprednisolone; Prothrombin Time; Terfenadine; Theophylline; Warfarin | 1995 |
In vitro plasma protein binding of zileuton and its N-dehydroxylated metabolite.
Topics: Adult; Anti-Allergic Agents; Anti-Inflammatory Agents; Anticoagulants; Blood Proteins; Chromatography, High Pressure Liquid; Drug Interactions; Female; Hematocrit; Humans; Hydroxylation; Hydroxyurea; Ibuprofen; In Vitro Techniques; Isotope Labeling; Lipoxygenase Inhibitors; Male; Naproxen; Prednisolone; Protein Binding; Salicylates; Stereoisomerism; Terfenadine; Theophylline; Warfarin | 1995 |
Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19.
Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Humans; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Theophylline; Tranylcypromine; Warfarin | 1996 |
Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Kinetics; Liver; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Proton-Translocating ATPases; Rabbits; Rabeprazole; Recombinant Proteins; Sulfaphenazole; Theophylline | 1996 |
Zileuton for asthma.
Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Intestinal Absorption; Leukotrienes; Lipoxygenase Inhibitors; Propranolol; Theophylline; Warfarin | 1997 |
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Escherichia coli; Ethanolamines; Humans; Hydroxylation; Mixed Function Oxygenases; Mutation; NADP; Nifedipine; Oxidation-Reduction; Phospholipids; Recombinant Proteins; Testosterone; Theophylline; Tolbutamide; Warfarin | 1997 |
Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes.
Topics: Adult; Aged; Anisoles; Anti-Infective Agents; Anticoagulants; Antifungal Agents; Antimalarials; Binding, Competitive; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Kinetics; Male; Methylation; Microsomes, Liver; Middle Aged; Quinidine; Substrate Specificity; Sulfaphenazole; Theophylline | 1997 |
Interaction of oral anticoagulants with methyl xanthines.
Topics: Animals; Anticoagulants; Biological Availability; Caffeine; Central Nervous System Stimulants; Dicumarol; Drug Interactions; Male; Rabbits; Spectrophotometry, Ultraviolet; Theophylline; Thermodynamics; Warfarin; Xanthines | 1997 |
Continuous blood withdrawal as a rapid screening method for determining clearance of oral bioavailability in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Atenolol; Biological Availability; Male; Propranolol; Rats; Rats, Sprague-Dawley; Theophylline; Warfarin | 1998 |
Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes.
Topics: Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cholecalciferol; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Ethanolamines; Humans; Isoenzymes; Lauric Acids; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Paclitaxel; Prostaglandins; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tretinoin; Warfarin; Xenobiotics | 1999 |
Prevalence of potential proton-pump inhibitor drug interactions: a retrospective review of prescriptions in community pharmacies.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Diazepam; Drug Interactions; Enzyme Inhibitors; Humans; Lansoprazole; Omeprazole; Pharmacies; Prevalence; Proton Pump Inhibitors; Retrospective Studies; Theophylline; Warfarin | 1999 |
Drug interactions avoided-a useful indicator of good prescribing practice.
Topics: Anticoagulants; Anticonvulsants; Cimetidine; Drug Interactions; Drug Prescriptions; Histamine H2 Antagonists; Humans; Ireland; Odds Ratio; Phenytoin; Theophylline; Vasodilator Agents; Warfarin | 2000 |
Evaluation of solid-state forms present in tablets by Raman spectroscopy.
Topics: Anti-Inflammatory Agents; Anti-Ulcer Agents; Anticoagulants; Antihypertensive Agents; Bronchodilator Agents; Enalapril; Fourier Analysis; Prednisolone; Ranitidine; Spectrum Analysis, Raman; Tablets; Theophylline; Warfarin | 2000 |
Bisoprolol: studies of potential interactions with theophylline and warfarin in healthy volunteers.
Topics: Adrenergic beta-Antagonists; Adult; Anticoagulants; Bisoprolol; Cross-Over Studies; Drug Interactions; Female; Humans; Male; Middle Aged; Prothrombin Time; Theophylline; Vasodilator Agents; Warfarin | 1990 |
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline | 2002 |
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline | 2003 |
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene | 2005 |
Bronchodilator activity of Phymatodes scolopendria (Burm.) Ching and its bioactive constituent.
Topics: Animals; Bronchodilator Agents; Calcium Chloride; Coumarins; Female; Guinea Pigs; Histamine Antagonists; Male; Plant Extracts; Polypodiaceae; Potassium Chloride; Propranolol; Theophylline; Trachea | 2005 |
Prevalence and predictors of potential drug-drug interactions in Regione Emilia-Romagna, Italy.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Aminophylline; Anti-Inflammatory Agents, Non-Steroidal; Barbiturates; Child; Child, Preschool; Ciprofloxacin; Drug Interactions; Drug Utilization; Female; Fluvoxamine; Humans; Italy; Male; Middle Aged; Outpatients; Theophylline; Warfarin | 2008 |
Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats.
Topics: Animals; Anticoagulants; Herb-Drug Interactions; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Rhodiola; Theophylline; Warfarin | 2009 |
Synthesis of coumarin-theophylline hybrids as a new class of anti-tubercular and anti-microbial agents.
Topics: Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Coumarins; Dose-Response Relationship, Drug; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Salmonella typhi; Staphylococcus aureus; Structure-Activity Relationship; Theophylline | 2018 |
Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice.
Topics: Animals; Coumarins; Cytochrome P-450 CYP1A2; Hepatocytes; Humans; Mice; Microsomes, Liver; Theophylline | 2021 |