theophylline and uric acid

theophylline has been researched along with uric acid in 144 studies

Research

Studies (144)

Timeframe	Studies, this research(%)	All Research%
pre-1990	65 (45.14)	18.7374
1990's	42 (29.17)	18.2507
2000's	20 (13.89)	29.6817
2010's	13 (9.03)	24.3611
2020's	4 (2.78)	2.80

Authors

Authors	Studies
Cameron, IL; Lyles, MB; Rawls, HR	1
Bearne, SL; Lunn, FA; Roy, AC	1
Boumendil-Podevin, EF; Podevin, RA	1
Davis, BB; Zenser, TV	1
Lowitt, S; Polson, JB; Szentivanyi, A; Williams, JF	1
Caldwell, J; Monks, TJ; Smith, RL	1
Shoyab, M	1
Desiraju, RK; Mayock, RL; Sugita, ET	1
Johnson, GF; Kiser, EJ; Witte, DL	1
Kihlman, BA; Sturelid, S	1
Letellier, G; Vinet, B	1
Mensen, H	1
Turner, T; Vasiliades, J	1
Chidsey, C; Weinberger, M	1
Jenne, JW; Nagasawa, HT; Thompson, RD	2
Andersson, HC; Kihlman, BA	1
Dean, PM; Edwardson, JM	1
Fuhr, U; Roots, I; Rost, KL; Staib, AH	1
Coates, PE; Elias-Jones, AC; Leakey, TE; Smith, KJ	1
Hsu, CH; Patel, SR; Vanholder, R; Young, EW	1
Higashino, K; Hiroishi, K; Moriwaki, Y; Suda, M; Takahashi, S; Yamamoto, T	1
Botteron, GW; Hughes, EM; Hurwitz, A; Jayaraj, A; Sztern, MI; Vacek, JL	1
Birkett, DJ; Day, RO; Miners, JO	1
Grishanova, AIu; Guliaeva, LF; Mishin, VM; Vavilin, VA	1
Hasegawa, T; Kuzuya, T; Muraoka, I; Nadai, M; Takagi, K; Yoshizumi, H	1
Kawanishi, K	1
Beitins, IZ; Kilbane, AJ; Manis, M; Silbart, LK; Weber, WW	1
Guzelian, PS; Hunt, C; Karnes, HT; Polk, RE; Sarkar, M	1
Advenier, C; Beaumont, D; Brion, N; Naline, E; Pays, M	1
Furuta, T; Kasuya, Y; Shimota, H	1
Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, GJ	1
Hori, R; Kishimoto, I; Okumura, K; Tanigawara, Y	1
Hafkenscheid, JC; Hekster, YA; Nouws, JF; Vree, JB; Vree, TB	1
Berdel, D; Bonnacker, I; Süverkrüp, R; von Berg, A	1
Adachi, K; Hirota, N; Kobayashi, S; Yamawaki, H	1
Birkett, DJ; Gregor, D; McManus, ME; Miners, JO; Stupans, I	1
Beck, R; Knoppert, DC; MacLeod, SM; Spino, M; Thiessen, JJ	1
Juan, D; Rammohan, M; Shin, SG	1
Rogge, MC; Sedman, AJ; Solomon, WR; Toothaker, RD; Wagner, JG; Welling, PG	1
Hafkenscheid, JC; Hekster, YA; Martea, M; Tiggeler, RG; Vree, TB	1
Dorigo, P; Gaion, RM; Gambarotto, L	1
Beckmann, J; Elsässer, W; Gundert-Remy, U; Hertrampf, R	1
Levy, G; Ramzan, IM	1
Bompadre, S; Ercolani, P; Leone, L	1
du Souich, P; Hartemann, D; Saunier, C; Sautegeau, A	1
Chakraborty, J; Marks, V; Scott, NR	1
Gundert-Remy, U; Hildebrandt, R; Krüdewagen, B	1
Geoffroy, S; Gilbert, SG; Klassen, RD; Rice, DC; So, Y; Stavric, B	1
Hoffstein, S; Weissmann, G; Zurier, RB	1
Fernandez, F; Passanante, D; Rotman, LJ; Sermukslis, B; Smud, R	1
Chilcote, DD; Mrochek, JE	1
Phelps, P; Tse, RL; Urban, D	1
Barnes, FS; Gamow, E	1
Cornish, HH; Khanna, KL; Rao, GS	2
Riegelman, S; Shah, VP	1
Lumb, JR; Shankel, DM; Sideropoulos, AS	1
Goldstein, IM; Spieler, PJ; Weissmann, G; Zurier, RB	1
Chytil, F	1
Shefter, E	1
Friedman, PA	1
Gehl, A; Rink, M	1
Ainardi, V; Opheim, KE; Raisys, VA	1
Kamatani, N; Miyamoto, T; Morita, Y; Nishida, Y	1
Berdel, D; Heimann, G	1
Miyamoto, T; Morita, Y; Nishida, Y	1
Gundert-Remy, U; Hildebrandt, R; Möller, H; Weber, E	1
Bennett, MJ; Patchett, BP; Worthy, E	1
Attwood, J; Birkett, DJ; Miners, JO	1
Kela, U; Trivedi, CP; Vijayvargiya, R	1
Hemsworth, TC; Renton, KW	1
Riegelman, S; Tang-Liu, DD; Williams, RL	1
Granit, D; Superstine, E; Yosselson-Superstine, S	1
Bonati, M; Garattini, S; Latini, R; Marzi, E	1
Birkett, DJ; Grygiel, JJ	1
Jonkman, JH; Riegelman, S; Tang, D; Upton, RA	1
Aarons, L; Davis, JD; Houston, JB	1
Chen, J; Follath, F; Freiburghaus, AU; Ha, HR	1
Kaminsky, LS; Zhang, ZY	1
Jang, IJ; Kim, SW; Lee, KH; Lee, SH; Lee, SW; Oh, SJ; Shin, SG; Yim, DS	1
Kuroume, T; Maeda, S; Mochizuki, H; Morikawa, A; Shimizu, T; Tokuyama, K	1
Konishi, H; Morita, K; Yamaji, A	1
Galteau, MM; Gueguen, R; Pontes, ZB; Siest, G; Vincent-Viry, M	1
Roots, I; Rost, KL	1
Andersson, T; Birkett, DJ; McManus, ME; Miners, JO; Tassaneeyakul, W; Tukey, RH; Veronese, ME	1
Iwaki, M; Ogiso, T; Okuyama, K; Tanino, T; Uno, S	1
Franzini, C; Kratochvila, J; Middle, J; Ricós, C; Siekmann, L; Stöckl, D; Thienpont, LM	1
Iga, T; Kawakami, J; Sawada, Y; Toyama, E; Yamamoto, K	1
Fujiwara, I; Mizuki, Y; Sekine, Y; Yamaguchi, T	1
Bartsch, H; Bernucci, I; Caporaso, NE; Kadlubar, FF; Landi, MT; Malaveille, C; Shields, P; Skipper, P; Tannenbaum, S; Vineis, P; Zocchetti, C	1
De Leenheer, AP; Reinauer, H; Stöckl, D; Thienpont, LM; Van Nieuwenhove, B	1
Bantle, JA; Fort, DJ; Hull, MA; Propst, T; Stover, EL	1
Benchekroun, Y; Brazier, JL; Dautraix, S; Désage, M	1
Lunte, CE; Zhao, Y	1
Norman, A; Rodopoulos, N	1
Boichis, H; Jordan, S; Laufer, J; Mazkereth, R; Pomerance, JJ; Reichman, B	1
Goriki, K; Ochiai, M; Okusaki, K; Takahashi, H; Toda, K; Tokunou, H; Uehara, S	1
Asoh, M; Kobayashi, S; Koitabashi, Y; Okano, YJ; Tateishi, T; Yamaguchi, A; Yoda, T	1
Bernal, ML; Fanlo, A; Juste, JL; Lanuza, J; Mayayo, E; Sáenz, MA; Sinués, B	1
Kim, J; Ko, G; Park, EJ; Sohn, DH	1
Kuh, HJ; Shim, CK	1
Cao, W; Chen, G; Ling, SS; Zhuo, HT	1
Madhavi, YS; Madyastha, KM; Sridhar, GR; Vadiraja, BB	1
Cao, XM; Ling, SS; Lu, JF; Yi, T; Zhuo, HT	1
Cao, XM; Lin, SS; Lu, JF; Yi, T; Zhuo, HT	1
Crews, HM; Olivier, L; Wilson, LA	1
Hammons, G; Kadlubar, FF; Lang, NP; Nowell, S; Sweeney, C	1
Abraham, K; Bauer, S; Brockmöller, J; Geusau, A; Helge, H; Tosun, Y	1
Kim, EJ; Lee, MG; Suh, OK	1
CHRISTMAN, AA; WEINFELD, H	1
JEFFREY, JJ; SCHANKER, LS; TOCCO, DJ	1
SIMON, MI; VANVUNAKIS, H	1
Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y	1
Kim, SG; Kim, SH; Kim, YC; Lee, AK; Lee, DC; Lee, I; Lee, JH; Lee, MG	1
Miyazaki, K; Mochizuki, T; Sugawara, M; Takekuma, Y	1
Li, J; Peng, XQ; Xu, JP; Zhang, J	1
Chang, YS; Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y	1
Asprodini, EK; Begas, E; Kouvaras, E; Papakosta, S; Tsakalof, A	1
Hasegawa, T; Kato, M; Kimura, M; Nadai, M; Tsunekawa, Y; Ueyama, J; Yasui, K; Yoshizumi, H; Zhao, YL	1
Abe, M; Hamada, H; Higaki, J; Inata, J; Kadowaki, T; Kohno, N; Kuraoka, T; Moritani, C; Nishimura, K; Yokoyama, A	1
Bae, SK; Choi, HD; Chung, HJ; Kang, HE; Lee, MG; Shin, KN	1
Fanlo, A; Ferrandez-Longás, A; Labarta, JI; Mayayo, E; Mayayo-Sinués, E; Sinués, B; Vicente, J	1
Lee, JH; Lee, MG; Yang, KH	1
Jung, YS; Kim, YC; Lee, DY; Lee, JH; Lee, MG; Yang, KH	1
Arenaz, I; Carcas, C; Cebollada, A; Fanlo, A; Mayayo, E; Sinues, B; Vicente, J	1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL	1
Ashida, H; Hashimoto, T; Kanazawa, K; Nakabayashi, H; Nishiumi, S	1
Chohnabayashi, N; Kizu, J; Nasu, H; Nishimura, N; Uchiyama, N; Watanabe, Y	1
Chae, JW; Kim, DH; Kim, Ej; Kwon, KI; Lee, BY	1
Kamataki, T; Kimura, M; Kiyotani, K; Nakagawa, K; Shimizu, M; Yamazaki, H	1
Fan, XR; Li, XY; Li, YF; Li, YP; Liu, YN; Yang, M; Yao, XC; Yin, YM; Yuan, M; Zhu, JB	1
Aravind, UK; Aravindakumar, CT; Pramod, G; Saha, A; Sunil Paul, MM	1
Chen, XY; Liu, Y; Zhan, Y; Zhang, YF; Zhong, DF	1
Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR	1
Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP	1
Adehin, A; Bolaji, OO	1
Cho, JY; Choi, CW; Kim, BI; Kim, EK; Kim, HS; Lee, J; Lee, JA; Oh, J; Park, EA; Shin, SH; Sohn, JA; Yu, KS	1
Dong, ZB; Liang, YR; Lu, J; Ma, YX; Wu, HS; Wu, XH; Ye, JH; Zheng, XQ	1
Enoki, Y; Hori, S; Kizu, J; Kuroda, Y; Matsumoto, K; Taguchi, K	1
Fan, Y; Gao, F; Ma, X; Qian, L; Wang, W; Yan, B; Yang, J; Zhao, B	1
Kertys, M; Kmeťová, K; Maráková, K; Mokrý, J; Pršo, K; Žideková, N	1
Aoyama, K; Bhadhprasit, W; Kinoshita, C; Matsumura, N; Nakaki, T	1
Aoyama, K; Matsumura, N	1

Reviews

3 review(s) available for theophylline and uric acid

Article	Year
Analytical specifications of reference methods compilation and critical discussion (from the members of the European EQA-Organizers Working Group B). European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1996, Volume: 34, Issue:4 Topics: Blood Glucose; Blood Proteins; Chemistry, Clinical; Cholesterol; Creatinine; Electrolytes; Europe; Hormones; Laboratories; Reference Standards; Theophylline; Thyroxine; Triglycerides; Uric Acid	1996
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. Current topics in medicinal chemistry, 2015, Volume: 15, Issue:21 Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobromine; Theophylline; Uric Acid	2015
Glutathione-Mediated Neuroprotective Effect of Purine Derivatives. International journal of molecular sciences, 2023, Aug-22, Volume: 24, Issue:17 Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Brain; Caffeine; Cysteine; Excitatory Amino Acid Transporter 3; Glutathione; Humans; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Purines; Receptor, Adenosine A2A; Theophylline; Uric Acid	2023

Trials

6 trial(s) available for theophylline and uric acid

Article	Year
Cystic fibrosis: enhanced theophylline metabolism may be linked to the disease. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:3 Topics: Adolescent; Adult; Biotransformation; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Cystic Fibrosis; Double-Blind Method; Humans; Male; Random Allocation; Theophylline; Uric Acid; Xanthines	1988
[Peculiarities of the pharmacokinetics and pharmacodynamics of theophylline in children]. Wiener klinische Wochenschrift, 1984, Aug-31, Volume: 96, Issue:16 Topics: Adolescent; Asthma; Bronchitis; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Infant, Premature; Kinetics; Theophylline; Uric Acid; Xanthines	1984
Effect of fluconazole on theophylline disposition in humans. European journal of clinical pharmacology, 1994, Volume: 46, Issue:4 Topics: Adult; Cross-Over Studies; Enoxacin; Female; Fluconazole; Humans; Male; Metabolic Clearance Rate; Theophylline; Uric Acid; Xanthines	1994
Urinary biomarkers for assessing dietary exposure to caffeine. Food additives and contaminants, 2001, Volume: 18, Issue:12 Topics: Adult; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Diet; Female; Humans; Liver; Male; Middle Aged; Phenotype; Theophylline; Time Factors; Uric Acid; Xanthines	2001
Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. European journal of clinical pharmacology, 2006, Volume: 62, Issue:8 Topics: Alleles; Asthma; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Genotype; Humans; Pharmacogenetics; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Theophylline; Uric Acid	2006
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers. Drug metabolism letters, 2012, Jun-01, Volume: 6, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genotype; Humans; Japan; Male; Phenotype; Pilot Projects; Theophylline; Uric Acid; Xanthines; Young Adult	2012

Other Studies

135 other study(ies) available for theophylline and uric acid

Article	Year
Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26 Topics: Acridine Orange; Intercalating Agents; Methylation; Nonlinear Dynamics; Spectrophotometry; Structure-Activity Relationship; Xanthines	2001
Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Kinetics; Methylation; Structure-Activity Relationship; Uric Acid; Xanthines	2010
Inhibition by cyclic AMP and dibutyryl cyclic AMP of transport of organic acids in kidney cortex. Biochimica et biophysica acta, 1975, Jan-14, Volume: 375, Issue:1 Topics: Aminohippuric Acids; Animals; Biological Transport; Bucladesine; Cyclic AMP; In Vitro Techniques; Isoproterenol; Kidney Cortex; Kinetics; Male; Potassium; Rabbits; Sodium; Theophylline; Uric Acid; Vasopressins	1975
Mechanism of inhibition of organic acid transport in rabbit renal cortex by cyclic AMP. Metabolism: clinical and experimental, 1976, Volume: 25, Issue:10 Topics: Adenine; Animals; Biological Transport, Active; Cyclic AMP; Cyclic GMP; Iodohippuric Acid; Isoproterenol; Kidney Cortex; Kinetics; Parathyroid Hormone; Propranolol; Rabbits; Theophylline; Uric Acid	1976
Pharmacological and biochemical activities of some monomethylxanthine and methyluric acid derivatives of theophylline and caffeine. Biochemical pharmacology, 1978, Volume: 27, Issue:11 Topics: Animals; Caffeine; Dogs; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Phosphoric Diester Hydrolases; Theophylline; Trachea; Uric Acid; Xanthines	1978
Influence of methylxanthine-containing foods on theophylline metabolism and kinetics. Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:4 Topics: Administration, Oral; Adult; Diet; Humans; Injections, Intravenous; Kinetics; Male; Theophylline; Uric Acid; Xanthines	1979
The stimulation of murine hepatic aryl hydrocarbon hydroxylase activity in vitro by caffeine. Cancer letters, 1979, Volume: 8, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Caffeine; DNA; Hypoxanthines; In Vitro Techniques; Mice; Microsomes, Liver; Stimulation, Chemical; Theobromine; Theophylline; Uric Acid	1979
Determination of theophylline and its metabolites by liquid chromatography. Journal of chromatographic science, 1977, Volume: 15, Issue:12 Topics: Chromatography, High Pressure Liquid; Humans; Saliva; Theobromine; Theophylline; Uric Acid; Xanthines	1977
Serum uric acid determined by reversed-phase liquid chromatography with spectrophotometric detection. Clinical chemistry, 1978, Volume: 24, Issue:4 Topics: Acetaminophen; Allopurinol; Chromatography, Liquid; Drug Interactions; Humans; Methods; Oxypurinol; Salicylates; Spectrophotometry, Ultraviolet; Theophylline; Urate Oxidase; Uric Acid	1978
Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations. Hereditas, 1975, Volume: 79, Issue:1 Topics: Animals; Caffeine; Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cricetinae; Drug Synergism; Methylation; Mutation; Plants; Purines; Theobromine; Theophylline; Thiotepa; Uric Acid	1975
The in vitro effect of drugs on biochemical parameters determined by a SMAC system. Clinical biochemistry, 1977, Volume: 10, Issue:1 Topics: Ascorbic Acid; Autoanalysis; Bilirubin; Blood Chemical Analysis; Blood Glucose; Creatinine; Evaluation Studies as Topic; Humans; Infant, Newborn; Methods; Pharmaceutical Preparations; Theophylline; Uric Acid	1977
[Rehabilitation course in patients with peripheral and coronary angio-organopathies. Studies with special reference to serum uric acid and cholesterol under xanthinol nicotinate]. Therapie der Gegenwart, 1977, Volume: 116, Issue:10 Topics: Adult; Cholesterol; Coronary Disease; Humans; Hypercholesterolemia; Middle Aged; Theophylline; Uric Acid; Vascular Diseases; Xanthinol Niacinate	1977
A modified ultraviolet spectrophotometric method for the determination of theophylline in serum in the presence of barbiturates. Clinica chimica acta; international journal of clinical chemistry, 1976, Jun-15, Volume: 69, Issue:3 Topics: Barbiturates; Caffeine; Humans; Hypoxanthines; Spectrophotometry, Ultraviolet; Theophylline; Uric Acid; Xanthines	1976
Rapid analysis for theophylline in serum by use of high-pressure cation-exchange chromatography. Clinical chemistry, 1975, Volume: 21, Issue:7 Topics: Chromatography, Ion Exchange; Humans; Hypoxanthines; Theophylline; Uric Acid; Xanthines	1975
Relationship of urinary metabolites of theophylline to serum theophylline levels. Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:3 Topics: Aged; Dealkylation; Humans; Mathematics; Middle Aged; Models, Biological; Theophylline; Uric Acid; Xanthines	1976
Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba. Mutation research, 1992, Volume: 269, Issue:2 Topics: Caffeine; Camptothecin; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylnitrosourea; Mutagenicity Tests; Mutagens; Plants; Purines; Theophylline; Uric Acid	1992
Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure. Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11 Topics: Allantoin; Alloxan; Animals; Barbiturates; Blood Glucose; Caffeine; Ethosuximide; Hyperglycemia; Inositol; Male; Mice; Phenytoin; Structure-Activity Relationship; Theophylline; Uric Acid	1992
Theophylline metabolism affected by mexiletine. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:1 Topics: Adult; Caffeine; Humans; Male; Mexiletine; Theophylline; Uric Acid; Xanthines	1992
Pharmacokinetics of theophylline and its metabolites during acute renal failure. A case report. Clinical pharmacokinetics, 1991, Volume: 21, Issue:5 Topics: Acute Kidney Injury; Asthma; Child, Preschool; Humans; Male; Metabolic Clearance Rate; Peritoneal Dialysis; Theophylline; Uric Acid	1991
Effects of purine derivatives on calcitriol metabolism in rats. The American journal of physiology, 1991, Volume: 260, Issue:4 Pt 2 Topics: Animals; Calcitriol; Cellulose; Cholestanetriol 26-Monooxygenase; DNA; Kidney; Kinetics; Male; Metabolic Clearance Rate; Purines; Rats; Rats, Inbred Strains; Receptors, Calcitriol; Receptors, Steroid; Steroid Hydroxylases; Theophylline; Uric Acid	1991
Theophylline-induced increase in plasma uric acid--purine catabolism increased by theophylline. International journal of clinical pharmacology, therapy, and toxicology, 1991, Volume: 29, Issue:7 Topics: Administration, Oral; Adult; Erythrocytes; Humans; Hypoxanthine; Hypoxanthines; Male; Nucleotides; Purines; Theophylline; Tumor Cells, Cultured; Uric Acid; Xanthine; Xanthines	1991
Mexiletine effects on theophylline disposition. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:3 Topics: Adult; Delayed-Action Preparations; Drug Interactions; Humans; Male; Mexiletine; Theophylline; Uric Acid	1991
1-Methylxanthine derived from theophylline as an in vivo biochemical probe of allopurinol effect. British journal of clinical pharmacology, 1991, Volume: 32, Issue:2 Topics: Adult; Allopurinol; Biomarkers; Female; Humans; Male; Oxypurinol; Theophylline; Uric Acid; Xanthines	1991
[Theophylline metabolism by rat liver microsomal monooxygenases]. Biokhimiia (Moscow, Russia), 1990, Volume: 55, Issue:10 Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Neprilysin; Rats; Rats, Inbred Strains; Theophylline; Uric Acid	1990
Effects of enoxacin on renal and metabolic clearance of theophylline in rats. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:9 Topics: Animals; Enoxacin; Kidney; Male; Rats; Rats, Inbred Strains; Theophylline; Uric Acid	1990
[Clinical laboratory application of HPLC]. Rinsho byori. The Japanese journal of clinical pathology, 1990, Volume: 38, Issue:1 Topics: Albumins; Chromatography, High Pressure Liquid; Humans; Immunoglobulin G; Theophylline; Uric Acid	1990
Human N-acetylation genotype determination with urinary caffeine metabolites. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4 Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines	1990
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:4 Topics: Biotransformation; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Hydroxylation; Microsomes, Liver; Norfloxacin; Theophylline; Uric Acid; Xanthines	1990
Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects. British journal of clinical pharmacology, 1989, Volume: 27, Issue:3 Topics: Adult; Benzhydryl Compounds; Drug Interactions; Humans; Male; Terfenadine; Theophylline; Time Factors; Uric Acid; Xanthines	1989
Capillary gas chromatographic-mass spectrometric determination of stable isotopically labelled and unlabelled theophylline in serum and urine and of 1,3-dimethyluric acid in urine. Journal of chromatography, 1989, Sep-29, Volume: 494 Topics: Alkylation; Carbon Isotopes; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Nitrogen Isotopes; Reference Standards; Theophylline; Uric Acid	1989
Drug-drug interactions affecting fluoroquinolones. The American journal of medicine, 1989, Dec-29, Volume: 87, Issue:6C Topics: Adult; Drug Interactions; Enoxacin; Humans; Male; Ofloxacin; Oxidation-Reduction; Theophylline; Uric Acid; Xanthines	1989
Blood oxygen tension-related change of theophylline clearance in experimental hypoxemia. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Animals; Hypoxia; Lung Diseases, Obstructive; Male; Metabolic Clearance Rate; Oxygen; Partial Pressure; Rats; Rats, Inbred Strains; Theophylline; Uric Acid	1989
Excretion and metabolism of a series of xanthines by the turtle Pseudemys scripta elegans. The veterinary quarterly, 1989, Volume: 11, Issue:1 Topics: Animals; Caffeine; Theobromine; Theophylline; Turtles; Uric Acid; Xanthine; Xanthines	1989
Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients. European journal of clinical pharmacology, 1989, Volume: 36, Issue:2 Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; Theophylline; Uric Acid; Urodynamics; Xanthines	1989
Does theophylline raise serum uric acid concentrations in asthmatic children? DICP : the annals of pharmacotherapy, 1989, Volume: 23, Issue:9 Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Infant; Male; Theophylline; Uric Acid	1989
Theophylline metabolism by human, rabbit and rat liver microsomes and by purified forms of cytochrome P450. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:6 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Theophylline; Uric Acid; Xanthines	1988
Theophylline pharmacokinetics in normal elderly subjects. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5 Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Theophylline; Uric Acid; Xanthines	1988
The theophylline-enoxacin interaction: I. Effect of enoxacin dose size on theophylline disposition. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Humans; Male; Theophylline; Uric Acid; Xanthines	1988
Pharmacokinetics of theophylline and its metabolites in a patient undergoing continuous ambulatory peritoneal dialysis. Clinical pharmacokinetics, 1988, Volume: 15, Issue:6 Topics: Aged; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis, Continuous Ambulatory; Theophylline; Uric Acid; Xanthines	1988
A reexamination of the effects induced by adenosine and its degradation products on rat fat cell lipolysis. Biochemical pharmacology, 1988, Sep-01, Volume: 37, Issue:17 Topics: Adenosine; Adenosine Deaminase; Adipose Tissue; Animals; Dose-Response Relationship, Drug; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Lipid Mobilization; Norepinephrine; Rats; Theophylline; Uric Acid	1988
Enoxacin--a potent inhibitor of theophylline metabolism. European journal of clinical pharmacology, 1987, Volume: 33, Issue:3 Topics: Adult; Anti-Infective Agents; Enoxacin; Humans; Naphthyridines; Theophylline; Uric Acid; Xanthines	1987
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3 Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Rats; Rats, Inbred Lew; Seizures; Theophylline; Uric Acid; Xanthines	1986
[Determination of theophylline in the plasma by rapid solid-phase extraction]. Bollettino della Societa italiana di biologia sperimentale, 1987, Aug-31, Volume: 63, Issue:8 Topics: Chromatography, High Pressure Liquid; Humans; Lung Diseases, Obstructive; Theophylline; Uric Acid; Xanthines	1987
Theophylline disposition during acute and chronic hypoxia in the conscious dog. Research communications in chemical pathology and pharmacology, 1987, Volume: 57, Issue:3 Topics: Acute Disease; Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Dogs; Female; Hypoxia; Male; Theophylline; Uric Acid; Xanthines	1987
Urinary metabolites of caffeine in pregnant women. British journal of clinical pharmacology, 1986, Volume: 22, Issue:4 Topics: Caffeine; Female; Humans; Pregnancy; Theophylline; Uric Acid; Xanthines	1986
Plasma concentrations of theophylline and its metabolites in a theophylline intoxicated child--reevaluation of published Km-values. British journal of clinical pharmacology, 1986, Volume: 22, Issue:5 Topics: Hemoperfusion; Humans; Infant; Kinetics; Theophylline; Uric Acid; Xanthines	1986
Elimination of chronically consumed caffeine in the pregnant monkey (Macaca fascicularis). The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3 Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Drinking; Eating; Female; Macaca fascicularis; Pregnancy; Pregnancy, Animal; Theophylline; Uric Acid	1986
Mechanisms of lysosomal enzyme release from human leukocytes. I. Effect of cyclic nucleotides and colchicine. The Journal of cell biology, 1973, Volume: 58, Issue:1 Topics: Arthritis, Rheumatoid; Carbon Isotopes; Colchicine; Cyclic AMP; Cytochalasin B; Glucose; Glucuronidase; Humans; Immunoglobulin G; Immunoglobulin M; Leukocytes; Lysosomes; Male; Microtubules; Phagocytosis; Prostaglandins; Spectrophotometry, Ultraviolet; Staining and Labeling; Theophylline; Time Factors; Uric Acid; Vinblastine; Zymosan	1973
[Modifications induced in the uric acid level by a combination niacin methoxyprophylline mucopolysaccharide and its interrelation with lipid metabolism]. Prensa medica argentina, 1970, Aug-07, Volume: 57, Issue:23 Topics: Aged; Arteriosclerosis; Glycosaminoglycans; Humans; Lipid Metabolism; Male; Middle Aged; Nicotinic Acids; Theophylline; Uric Acid	1970
Use of automatic digital data acquisition and on-line computer analysis in high-resolution liquid chromatography. Clinical chemistry, 1971, Volume: 17, Issue:8 Topics: Autoanalysis; Chromatography; Computers; Cyclic N-Oxides; Hippurates; Hypoxanthines; Mathematics; Methods; Niacinamide; Nicotinic Acids; Orotic Acid; Pyrimidines; Ribonucleosides; Spectrophotometry; Theophylline; Ultraviolet Rays; Uracil; Uric Acid; Xanthines	1971
Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP. The Journal of laboratory and clinical medicine, 1972, Volume: 80, Issue:2 Topics: Adenine; Caffeine; Cyclic AMP; Epinephrine; Guanine; Guanosine; Humans; Hypoxanthines; Imidazoles; Leukocytes; Movement; Purines; Pyrimidines; Reserpine; Structure-Activity Relationship; Theophylline; Thymine; Uracil; Uric Acid; Xanthines	1972
Chemotactic responses of human polymorphonuclear leukocytes to cyclic GMP and other compounds. Experimental cell research, 1974, Volume: 87, Issue:1 Topics: Adenosine Monophosphate; Adult; Bucladesine; Cells, Cultured; Chemotaxis; Cyclic AMP; Cyclic GMP; Guanine Nucleotides; Humans; Kaolin; Neutrophils; Theophylline; Uric Acid	1974
Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography. The Journal of laboratory and clinical medicine, 1974, Volume: 84, Issue:4 Topics: Administration, Oral; Aminophylline; Caffeine; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Ion Exchange; Humans; Hypoxanthines; Methylation; Pressure; Theophylline; Uric Acid; Xanthines	1974
Metabolism of caffeine- 3 H in the rat. Toxicology and applied pharmacology, 1972, Volume: 23, Issue:4 Topics: Animals; Caffeine; Chromatography, Thin Layer; Male; Mass Spectrometry; Rats; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Tritium; Uric Acid; Xanthines	1972
Mass spectrometric identification of methylxanthines and methyluric acids, the possible metabolites of caffeine. Journal of pharmaceutical sciences, 1972, Volume: 61, Issue:11 Topics: Caffeine; Chromatography, Gas; Mass Spectrometry; Methods; Methylation; Theobromine; Theophylline; Uric Acid; Xanthines	1972
GLC determination of theophylline in biological fluids. Journal of pharmaceutical sciences, 1974, Volume: 63, Issue:8 Topics: Barbiturates; Chromatography, Gas; Indicators and Reagents; Methods; Quaternary Ammonium Compounds; Saliva; Solvents; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Uric Acid; Xanthines	1974
The influence of analogs of xanthine on the mutagenic effect of ultraviolet light. Molecular & general genetics : MGG, 1968, Volume: 102, Issue:2 Topics: Caffeine; Drug Synergism; Escherichia coli; Mutation; Purines; Theophylline; Ultraviolet Rays; Uric Acid; Xanthines	1968
Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. The Journal of experimental medicine, 1971, Sep-01, Volume: 134, Issue:3 Pt 2 Topics: Acid Phosphatase; Antigen-Antibody Complex; Fluoresceins; Glucose; Glucuronidase; Humans; Immunoglobulin G; In Vitro Techniques; L-Lactate Dehydrogenase; Leukocytes; Lysosomes; Microscopy, Electron; Neutrophils; Phagocytosis; Prostaglandins; Rheumatoid Factor; Theophylline; Uric Acid; Zymosan	1971
Activation of liver tryptophan oxygenase by adenosine 3',5'-phosphate and by other purine derivatives. The Journal of biological chemistry, 1968, Mar-10, Volume: 243, Issue:5 Topics: Adenine Nucleotides; Adenosine Triphosphate; Allopurinol; Animals; Catalase; Hemoglobins; Hydrogen Peroxide; Hypoxanthines; Liver; Male; Nitrogen; Oxygen; Rats; Theophylline; Tryptophan Oxygenase; Uric Acid; Xanthine Oxidase	1968
Structural studies on complexes. I. Postulation of polarization bonding in xanthine complexes. Journal of pharmaceutical sciences, 1968, Volume: 57, Issue:2 Topics: Caffeine; Chemical Phenomena; Chemistry; Electrochemistry; Models, Chemical; Theophylline; Uric Acid; Xanthines	1968
Studies on the photodynamic reaction of purines and purine analogues with methylene blue. Biochimica et biophysica acta, 1968, Aug-23, Volume: 166, Issue:1 Topics: Anti-Bacterial Agents; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Light; Manometry; Mercaptopurine; Methylene Blue; Nucleosides; Oxygen Consumption; Purines; Spectrophotometry; Theophylline; Uric Acid; Xanthines	1968
[Thin-layer chromatographic separation of some purine derivatives, including uric acid]. Journal of chromatography, 1966, Volume: 21, Issue:1 Topics: Adenine; Caffeine; Chromatography, Thin Layer; Guanine; Hypoxanthines; Purines; Theobromine; Theophylline; Uric Acid; Xanthines	1966
Increase in apparent theophylline concentration in the serum of two patients as measured by some immunoassay methods (caused by 1,3-dimethyluric acid?) Clinical chemistry, 1983, Volume: 29, Issue:9 Topics: Chromatography, High Pressure Liquid; False Positive Reactions; Humans; Immunoenzyme Techniques; Reagent Kits, Diagnostic; Theophylline; Uremia; Uric Acid	1983
Theophylline increases serum uric acid levels. The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:5 Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Erythrocytes; Female; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Male; Middle Aged; Theophylline; Uric Acid	1984
[Mechanism of increase in the serum uric acid level caused by theophylline]. Arerugi = [Allergy], 1983, Volume: 32, Issue:3 Topics: Cells, Cultured; Erythrocytes; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Male; Purines; Theophylline; Uric Acid	1983
Lack of clinically important interaction between erythromycin and theophylline. European journal of clinical pharmacology, 1984, Volume: 26, Issue:4 Topics: Adult; Drug Interactions; Erythromycin; Female; Half-Life; Humans; Infusions, Parenteral; Injections, Intravenous; Kinetics; Male; Theophylline; Uric Acid; Xanthines	1984
A simple HPLC method for the determination of urate in serum and urine using 8-chlorotheophylline as internal standard. Medical laboratory sciences, 1984, Volume: 41, Issue:2 Topics: Chromatography, High Pressure Liquid; Humans; Reference Standards; Theophylline; Uric Acid	1984
Secondary metabolism of theophylline biotransformation products in man--route of formation of 1-methyluric acid. British journal of clinical pharmacology, 1983, Volume: 15, Issue:1 Topics: Biotransformation; Humans; Male; Theophylline; Uric Acid; Xanthines	1983
Inhibitory effects of methylxanthines on the activity of xanthine oxidase. Life sciences, 1980, Dec-01, Volume: 27, Issue:22 Topics: Animals; Brain; Buffaloes; Caffeine; Female; In Vitro Techniques; Kidney; Kinetics; Lung; Milk; Myocardium; Rats; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase; Xanthines	1980
Depression of theophylline metabolism and elimination by troleandomycin and erythromycin. Biochemical pharmacology, 1981, Jun-01, Volume: 30, Issue:11 Topics: Animals; Drug Interactions; Erythromycin; In Vitro Techniques; Male; Metabolic Clearance Rate; Microsomes, Liver; Rabbits; Theophylline; Troleandomycin; Uric Acid	1981
Nonlinear theophylline elimination. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Administration, Oral; Adult; Aminophylline; Biotransformation; Female; Humans; Infusions, Parenteral; Kinetics; Male; Models, Biological; Theophylline; Time Factors; Uric Acid; Xanthines	1982
Theophylline interference with the phosphotungstate uric acid test. American journal of hospital pharmacy, 1980, Volume: 37, Issue:11 Topics: Adolescent; Adult; Aged; Drug Interactions; Female; Humans; Male; Middle Aged; Phosphotungstic Acid; Theophylline; Uric Acid	1980
Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man. Toxicology letters, 1981, Volume: 7, Issue:3 Topics: Adult; Animals; Biotransformation; Caffeine; Humans; Macaca fascicularis; Male; Rats; Species Specificity; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines	1981
Cigarette smoking and theophylline clearance and metabolism. Clinical pharmacology and therapeutics, 1981, Volume: 30, Issue:4 Topics: Adult; Biotransformation; Cytochrome P-450 Enzyme System; Female; Humans; Male; Metabolic Clearance Rate; Smoking; Theophylline; Uric Acid; Xanthines	1981
Measurement of excretion characteristics of theophylline and its major metabolites. European journal of clinical pharmacology, 1981, Volume: 20, Issue:6 Topics: Humans; Kinetics; Theophylline; Uric Acid; Xanthines	1981
Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:6 Topics: Animals; Anti-Infective Agents; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Enoxacin; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Xanthines	1995
Metabolism of theophylline by cDNA-expressed human cytochromes P-450. British journal of clinical pharmacology, 1995, Volume: 39, Issue:3 Topics: Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Epoxide Hydrolases; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Smoking; Theophylline; Tumor Cells, Cultured; Uric Acid; Xanthines	1995
Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation. Biochemical pharmacology, 1995, Jul-17, Volume: 50, Issue:2 Topics: Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Kinetics; Methylation; Microsomes, Liver; Oxidoreductases; Theophylline; Transfection; Uric Acid	1995
CYP1A2 activity as a risk factor for bladder cancer. Journal of Korean medical science, 1994, Volume: 9, Issue:6 Topics: Acetylation; Adult; Aged; Amines; Carcinoma, Transitional Cell; Case-Control Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Disease Susceptibility; Enzyme Induction; Female; Humans; Isoniazid; Korea; Logistic Models; Male; Methylation; Metoprolol; Middle Aged; Mixed Function Oxygenases; Oxidoreductases; Smoking; Theophylline; Uric Acid; Urinary Bladder Neoplasms	1994
Effect of theophylline on serum uric acid levels in children with asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1994, Volume: 31, Issue:5 Topics: Adolescent; Asthma; Child; Female; Humans; Male; Substance Withdrawal Syndrome; Theophylline; Uric Acid	1994
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes. Genetic epidemiology, 1994, Volume: 11, Issue:2 Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines	1994
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test. Clinical pharmacology and therapeutics, 1994, Volume: 55, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Male; Mephenytoin; Middle Aged; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Theophylline; Uric Acid	1994
Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochemical pharmacology, 1994, May-18, Volume: 47, Issue:10 Topics: Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases; Theobromine; Theophylline; Uric Acid	1994
Effect of mexiletine on elimination and metabolic conversion of theophylline and its major metabolites in rats. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:2 Topics: Administration, Oral; Aminophylline; Animals; In Vitro Techniques; Injections, Intravenous; Liver; Male; Mexiletine; Rats; Rats, Wistar; Theophylline; Uric Acid; Xanthines	1993
Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:6 Topics: Animals; Blood-Brain Barrier; Brain; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; Neurotoxins; Seizures; Theophylline; Uric Acid; Xanthines	1996
Structure-related inhibitory effect of antimicrobial enoxacin and derivatives on theophylline metabolism by rat liver microsomes. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:8 Topics: Animals; Anti-Infective Agents; Crystallography, X-Ray; Electrochemistry; Enoxacin; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Molecular Structure; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Theophylline; Uric Acid	1996
Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:9 Topics: Age Factors; Alcohol Drinking; Aminobiphenyl Compounds; Arylamine N-Acetyltransferase; Caffeine; Carcinogens; Coffee; Cytochrome P-450 CYP1A2; DNA Adducts; Drinking; Enzyme Induction; Glutathione Transferase; Hemoglobins; Humans; Male; Meat; Middle Aged; Nicotiana; Oxidation-Reduction; Phenotype; Plants, Toxic; Polymorphism, Genetic; Risk Factors; Smoking; Theophylline; Uric Acid; Urinary Bladder Neoplasms	1996
Determination of reference method values by isotope dilution-gas chromatography/mass spectrometry: a five years' experience of two European Reference Laboratories. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1996, Volume: 34, Issue:10 Topics: Aldosterone; Blood Glucose; Cholesterol; Creatinine; Estradiol; Europe; Gas Chromatography-Mass Spectrometry; Guidelines as Topic; Humans; Hydrocortisone; Laboratories; Progesterone; Reference Values; Testosterone; Theophylline; Thyroxine; Triglycerides; Uric Acid	1996
Evaluation of the developmental toxicity of theophylline, dimethyluric acid, and methylxanthine metabolites using Xenopus. Drug and chemical toxicology, 1996, Volume: 19, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Embryo, Nonmammalian; Embryonic and Fetal Development; Female; In Vitro Techniques; Male; Theophylline; Uric Acid; Xanthines; Xenopus laevis	1996
Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine. Journal of chromatography. B, Biomedical sciences and applications, 1997, Jan-24, Volume: 688, Issue:2 Topics: Animals; Caffeine; Deuterium; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Kidney; Male; Rats; Rats, Wistar; Theobromine; Theophylline; Uric Acid	1997
Determination of caffeine and its metabolites by micellar electrokinetic capillary electrophoresis. Journal of chromatography. B, Biomedical sciences and applications, 1997, Jan-24, Volume: 688, Issue:2 Topics: Animals; Beverages; Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Rats; Sodium Dodecyl Sulfate; Tablets; Theobromine; Theophylline; Uric Acid	1997
Elimination of theophylline metabolites in healthy adults. Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:3 Topics: Administration, Oral; Adult; Female; Humans; Male; Middle Aged; Theophylline; Time Factors; Uric Acid; Xanthines	1997
Effects of theophylline on renal function in premature infants. American journal of perinatology, 1997, Volume: 14, Issue:1 Topics: Absorption; Aminophylline; Blood Pressure; Calcium; Creatinine; Diuretics; Drinking; Gestational Age; Heart Rate; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Kidney; Kidney Tubules; Nephrons; Phosphodiesterase Inhibitors; Phosphorus; Potassium; Sodium; Theophylline; Uric Acid; Urine	1997
Gout due to xanthine derivatives. British journal of rheumatology, 1997, Volume: 36, Issue:10 Topics: Allopurinol; Aminophylline; Asthma; Benzbromarone; Bronchodilator Agents; Drug Therapy, Combination; Female; Gout; Humans; Middle Aged; Probenecid; Theophylline; Uric Acid; Uricosuric Agents	1997
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients. Pediatric research, 1999, Volume: 45, Issue:1 Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Theophylline; Uric Acid; Xanthines	1999
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:2 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines	1999
Biotransformation of theophylline in cirrhotic rats induced by biliary obstruction. Archives of pharmacal research, 1999, Volume: 22, Issue:1 Topics: Animals; Area Under Curve; Biotransformation; Body Weight; Bronchodilator Agents; Cholestasis; Half-Life; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Microsomes, Liver; Organ Size; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid	1999
Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats. Archives of pharmacal research, 1994, Volume: 17, Issue:2 Topics: Animals; Biotransformation; Bronchodilator Agents; Infusions, Intravenous; Injections, Intravenous; Male; Nonlinear Dynamics; Probenecid; Rats; Rats, Wistar; Renal Agents; Theophylline; Uric Acid	1994
Pharmacokinetics of theophylline metabolites in 8 Chinese patients. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:5 Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Circadian Rhythm; Humans; Middle Aged; Theophylline; Uric Acid; Xanthines	1998
Purification and partial characterization of caffeine oxidase--A novel enzyme from a mixed culture consortium. Biochemical and biophysical research communications, 1999, Sep-24, Volume: 263, Issue:2 Topics: Caffeine; Klebsiella; Oxidation-Reduction; Oxygenases; Rhodococcus; Substrate Specificity; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase	1999
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11 Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	1997
[HPLC determination of five caffeine metabolites]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:8 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines	1997
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002, Volume: 11, Issue:4 Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Colorectal Neoplasms; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Risk Factors; Theophylline; Uric Acid	2002
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2 Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines	2002
Pharmacokinetics of intravenous theophylline in mutant Nagase analbuminemic rats. Life sciences, 2003, Jan-31, Volume: 72, Issue:11 Topics: Animals; Area Under Curve; Blood Protein Disorders; Cytochrome P-450 CYP1A2; Enzyme Induction; Infusions, Intravenous; Kidney; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Serum Albumin; Theophylline; Uric Acid	2003
The metabolism of caffeine and theophylline. The Journal of biological chemistry, 1953, Volume: 200, Issue:1 Topics: Body Fluids; Caffeine; Humans; Theophylline; Uric Acid; Urine	1953
INTERACTION OF PURINES WITH THE PYRIMIDINE TRANSPORT PROCESS OF THE SMALL INTESTINE. Biochemical pharmacology, 1963, Volume: 12 Topics: Adenine; Caffeine; Carbon Isotopes; Guanine; Intestine, Small; Intestines; Mercaptopurine; Pharmacology; Physiology; Purines; Pyrimidines; Rats; Research; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines	1963
THE DYE-SENSITIZED PHOTOOXIDATION OF PURINE AND PYRIMIDINE DERIVATIVES. Archives of biochemistry and biophysics, 1964, Volume: 105 Topics: Caffeine; Guanine; Guanine Nucleotides; Hydrogen-Ion Concentration; Hypoxanthines; Infrared Rays; Light; Manometry; Methylene Blue; Nucleosides; Oxidation-Reduction; Purines; Research; Theobromine; Theophylline; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uric Acid; Xanthines	1964
High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites. Clinical chemistry, 2004, Volume: 50, Issue:11 Topics: Bronchodilator Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Plasma; Theophylline; Uric Acid; Xanthines	2004
Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2005, Volume: 26, Issue:1 Topics: Administration, Oral; Alloxan; Aminophylline; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Diabetes Mellitus, Experimental; Enzyme Induction; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Theophylline; Uric Acid	2005
Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites. Biochimica et biophysica acta, 2005, Aug-15, Volume: 1714, Issue:2 Topics: Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Cricetulus; Humans; Molecular Structure; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Theobromine; Theophylline; Uric Acid; Xanthines	2005
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:3 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines	2006
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	2007
Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome P450 1A2 in rats. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3 Topics: Acyclovir; Animals; Antiviral Agents; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Wistar; Theophylline; Uric Acid; Vasodilator Agents; Xanthines	2007
Significance of serum uric acid in patients with chronic respiratory failure treated with non-invasive positive pressure ventilation. Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:11 Topics: Aged; Aged, 80 and over; Biomarkers; Blood Gas Analysis; Bronchodilator Agents; Chronic Disease; Creatinine; Diuretics; Female; Humans; Male; Middle Aged; Positive-Pressure Respiration; Predictive Value of Tests; Respiratory Insufficiency; Retrospective Studies; Severity of Illness Index; Theophylline; Thoracic Diseases; Uric Acid	2007
Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats. Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:8 Topics: Administration, Oral; Animals; Area Under Curve; Blood Proteins; Bronchodilator Agents; Dehydration; Half-Life; Injections, Intravenous; Male; Microsomes, Liver; Protein Binding; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Water Deprivation	2007
Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children. Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:1 Topics: Adolescent; Aryl Hydrocarbon Hydroxylases; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Genotype; Growth Disorders; Human Growth Hormone; Humans; Injections, Subcutaneous; Male; Mixed Function Oxygenases; Recombinant Proteins; Theophylline; Uric Acid	2008
Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU. The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:1 Topics: Animals; Area Under Curve; Benz(a)Anthracenes; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Activators; Half-Life; Infusions, Intravenous; Isoniazid; Metabolic Clearance Rate; Methylcholanthrene; Orphenadrine; Phosphodiesterase Inhibitors; Protein Binding; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Weight Gain	2008
Time-dependent effects of Klebsiella pneumoniae endotoxin (KPLPS) on the pharmacokinetics of theophylline in rats: return of the parameters in 96-hour KPLPS rats to the control levels. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5 Topics: Administration, Oral; Animals; Bronchodilator Agents; Cytochrome P-450 Enzyme System; Infusions, Intravenous; Klebsiella pneumoniae; Lipopolysaccharides; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid	2008
CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives. Human & experimental toxicology, 2008, Volume: 27, Issue:5 Topics: Adolescent; Adult; Age Factors; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Contraceptives, Oral; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Phenotype; Risk Factors; Sex Factors; Smoking; Spain; Theophylline; Uric Acid	2008
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. Journal of bacteriology, 2009, Volume: 191, Issue:14 Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2009
Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes. BioFactors (Oxford, England), 2008, Volume: 34, Issue:4 Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Biological Transport; Caffeine; Cell Differentiation; Glucose; Insulin; Lipid Metabolism; Mice; Theophylline; Uracil; Uric Acid; Xanthines	2008
Usefulness of the simultaneous determination of serum levels of theophylline and its metabolites in patients medicated with theophylline preparation. Biomedical chromatography : BMC, 2011, Volume: 25, Issue:4 Topics: Asthma; Bronchodilator Agents; Caffeine; Chromatography, High Pressure Liquid; Humans; Smoking; Theophylline; Uric Acid	2011
Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Mar-15, Volume: 889-890 Topics: Animals; Chromatography, Liquid; Drug Stability; Least-Squares Analysis; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2012
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2 Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines	2014
Hydroxyl radical induced oxidation of theophylline in water: a kinetic and mechanistic study. Organic & biomolecular chemistry, 2014, Aug-14, Volume: 12, Issue:30 Topics: Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxyl Radical; Hydroxylation; Kinetics; Light; Mass Spectrometry; Methylation; Oxidation-Reduction; Pulse Radiolysis; Spectrum Analysis; Theophylline; Uric Acid; Water; Xanthine	2014
[Quantitative analysis of theophylline and its metabolites in urine of Chinese healthy subjects after oral administration of theophylline sustained-release tablets]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:7 Topics: Administration, Oral; Asian People; Calibration; Chromatography, Liquid; Delayed-Action Preparations; Healthy Volunteers; Humans; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2014
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake. The Journal of nutrition, 2015, Volume: 145, Issue:4 Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult	2015
Polymorphisms of CYP1A2 and CYP2A6 activity: phenotypes and the effect of age and sex in a Nigerian population. Drug metabolism and personalized therapy, 2015, Volume: 30, Issue:3 Topics: Adolescent; Adult; Age Factors; Algorithms; Biomarkers; Biotransformation; Caffeine; Coffee; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Food, Preserved; Humans; Male; Nigeria; Sex Characteristics; Theophylline; Uric Acid; Young Adult	2015
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants. British journal of clinical pharmacology, 2017, Volume: 83, Issue:6 Topics: Aging; Apnea; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Female; Genotype; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Male; Theophylline; Uric Acid; Xanthines	2017
Different Catabolism Pathways Triggered by Various Methylxanthines in Caffeine-Tolerant Bacterium Journal of microbiology and biotechnology, 2018, Jul-28, Volume: 28, Issue:7 Topics: Biodegradation, Environmental; Caffeine; Drug Tolerance; Gardens; Metabolic Networks and Pathways; Pseudomonas putida; Soil; Soil Microbiology; Substrate Specificity; Tea; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2018
Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice. Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:8 Topics: Aging; Animals; Male; Mice, Inbred ICR; Theophylline; Uric Acid	2019
Genetically Determined Levels of Serum Metabolites and Risk of Neuroticism: A Mendelian Randomization Study. The international journal of neuropsychopharmacology, 2021, 01-20, Volume: 24, Issue:1 Topics: Adult; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Metabolome; Neuroticism; Polymorphism, Single Nucleotide; Theophylline; Uric Acid	2021
Simultaneous determination of caffeine and its metabolites in rat plasma by UHPLC-MS/MS. Journal of separation science, 2021, Volume: 44, Issue:23 Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Theobromine; Theophylline; Uric Acid	2021
A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis. Journal of pharmacological sciences, 2023, Volume: 151, Issue:1 Topics: Animals; Caffeine; Cysteine; Glutathione; HEK293 Cells; Humans; Hydrogen Peroxide; Mice; Neuroblastoma; Theophylline; Uric Acid	2023