theophylline and selegiline

theophylline has been researched along with selegiline in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's1 (5.88)18.2507
2000's8 (47.06)29.6817
2010's6 (35.29)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Akkari, R; Borrmann, T; Brunschweiger, A; Drabczyńska, A; Hockemeyer, J; Kieć-Kononowicz, K; Koch, P; Köse, M; Küppers, P; Müller, CE; Radjainia, H; Schlenk, M1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Antonov, L; Atanasov, AG; Hristova, S; Stammler, HG; Tzvetkov, NT1
Borges, F; Chavarria, D; Fernandes, C; Gil-Martins, E; Oliveira, PJ; Remião, F; Silva, C; Silva, R; Silva, T; Silva, V; Soares, P1
Cabanillas, AM; Coleoni, AH; Masini-Repiso, AM1
Müller-Limmroth, W1
Musshoff, F1
Anttila, M; Karnani, H; Nyman, L; Pelkonen, O; Salonen, JS; Taavitsainen, P1
Cody, JT1

Reviews

3 review(s) available for theophylline and selegiline

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine.
    Drug metabolism reviews, 2000, Volume: 32, Issue:1

    Topics: Amphetamines; Animals; Benzphetamine; Furans; Hair; Humans; Methamphetamine; Pyrazoles; Pyrazolones; Selegiline; Sydnones; Theophylline

2000
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.
    Journal of occupational and environmental medicine, 2002, Volume: 44, Issue:5

    Topics: Amphetamine; Amphetamines; Benzphetamine; Caffeine; Furans; Humans; Methamphetamine; Molecular Structure; Prenylamine; Prodrugs; Pyrazoles; Pyrazolones; Selegiline; Substance Abuse Detection; Sydnones; Theophylline

2002

Trials

1 trial(s) available for theophylline and selegiline

ArticleYear
[The effect of a new antiparkinson agent, Selegilin, on psychomotor performance in humans].
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:6

    Topics: Adult; Amphetamines; Antiparkinson Agents; Ethylamines; Humans; Male; Phenethylamines; Psychomotor Performance; Reaction Time; Selegiline; Theophylline

1985

Other Studies

13 other study(ies) available for theophylline and selegiline

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
    Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; CHO Cells; Cricetulus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Purinergic P1 Receptor Antagonists; Purines; Xanthines

2013
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.
    European journal of medicinal chemistry, 2019, Jan-15, Volume: 162

    Topics: Benzamides; Blood-Brain Barrier; Cerebral Cortex; Models, Neurological; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Permeability; Structure-Activity Relationship

2019
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
    European journal of medicinal chemistry, 2020, Jan-01, Volume: 185

    Topics: Alkaloids; Benzodioxoles; Caco-2 Cells; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Cells, Cultured

2020
Rat thyroid monoamine oxidase (MAO) is regulated by thyrotrophin: evidence that the main form of the enzyme (MAO-A) is not directly involved in iodide organification.
    The Journal of endocrinology, 1991, Volume: 131, Issue:1

    Topics: Animals; Bucladesine; Clorgyline; Depression, Chemical; Iodides; Isoenzymes; Male; Methimazole; Monoamine Oxidase; Rats; Rats, Inbred Strains; Selegiline; Theophylline; Thyroid Gland; Thyrotropin; Thyroxine

1991
Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes.
    Pharmacology & toxicology, 2000, Volume: 86, Issue:5

    Topics: Amphetamines; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Ketoconazole; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Selegiline; Theophylline

2000