theophylline has been researched along with rolipram in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (22.08) | 18.7374 |
| 1990's | 30 (38.96) | 18.2507 |
| 2000's | 22 (28.57) | 29.6817 |
| 2010's | 8 (10.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ichikawa, S; Ichimura, M; Kase, H; Kawakita, T; Kitamura, S; Kuroda, T; Manabe, H; Ohmori, K; Suzuki, F | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bristol, JA; Cain, MH; Weishaar, RE | 1 |
| Kasugai, S; Miyamoto, K; Ohya, K; Sawanishi, H; Suzuki, H; Suzuki, N; Takagi, K; Waki, Y; Yamamoto, S | 1 |
| Cooper, N; Dyke, HJ; Gowers, L; Gregory, JP; Hellewell, PG; Miotla, J; Montana, JG; Morris, K; Naylor, R; Tuladhar, B; Warneck, JB | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Jabaris, SS; Kodimuthali, A; Pal, M | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Bucki, A; Chłoń-Rzepa, G; Gawalska, A; Jankowska, A; Kołaczkowski, M; Pawłowski, M; Pociecha, K; Ślusarczyk, M; Świerczek, A; Wyska, E | 1 |
| An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T | 1 |
| Ainz, LF; Carou, M; Gáldiz, B; Gandarias, JM; Gil-Rodrigo, CE; Gómez, R; Vallejo, A | 1 |
| Gauthier, C; Le Bec, A; Lugnier, C; Soustre, H | 1 |
| Cortijo, J; Morcillo, EJ; Ortiz, JL; Vallés, JM | 1 |
| Donaldson, J; Hall, IP; Hill, SJ | 1 |
| Sadler, SE | 1 |
| Dragunow, M | 1 |
| Fredholm, BB; Lerner, U; Ransjö, M | 1 |
| Fredholm, BB; Lerner, UH; Ransjö, M | 1 |
| Cottney, J; Marsden, G; Nicholson, CD; Shahid, M | 1 |
| Fredholm, BB; Lerner, UH; Sahlberg, K | 1 |
| Klotz, KN; Schirren, CG; Schwabe, U; Ukena, D | 1 |
| Harvey, JA; Winsky, L | 1 |
| Hertting, G; Jackisch, R; Kasakov, L; Strittmatter, H | 1 |
| Fredholm, BB; Jonzon, B | 1 |
| Elfman, L; Fredholm, BB; Lindgren, E; Walum, E | 1 |
| Gustafsson, LE | 1 |
| Frossard, N; Landry, Y; Pauli, G; Ruckstuhl, M | 1 |
| Przegaliński, E; Rawłów, A | 1 |
| Fredholm, BB; Sandberg, G | 1 |
| Fredholm, BB; Gustafsson, L; Hedqvist, P | 1 |
| Fredholm, BB; Herrera-Marschitz, M; Jonzon, B; Lindström, K; Ungerstedt, U | 1 |
| Hatzelmann, A; Schudt, C; Tenor, H | 1 |
| Schudt, C; Sybrecht, GW; Ukena, D | 1 |
| Boichot, E; Hichami, A; Lagente, V; Martins, MA; Silva, PM | 1 |
| Meurs, H; Olymulder, CG; Santing, RE; Van der Molen, K; Zaagsma, J | 1 |
| Beleta, J; Bou, J; Cardelús, I; Cortijo, J; Gristwood, RW; Llenas, J; Morcillo, E | 1 |
| Howell, RE; Sickels, BD; Woeppel, SL | 1 |
| Blake, SM; Gozzard, N; Herd, CM; Higgs, GA; Holbrook, M; Hughes, B; Page, CP | 1 |
| Cheng, JB; Cohan, VL; Fisher, DA; Pazoles, CJ; Showell, HJ; Turner, CR; Watson, JW | 1 |
| Church, MK; Hatzelmann, A; Schudt, C; Shute, JK; Tenor, H | 1 |
| Dahl, SG; Lagente, V; Payne, AN; Planquois, JM; Ruffin-Morin, Y | 2 |
| Agematsu, K; Hu, B; Komiyama, A; Nakazawa, T; Yasui, K | 1 |
| Howell, LL; Landrum, AM | 1 |
| Ikezawa, K; Kaminuma, O; Kikkawa, H; Oka, K; Sugaya, T; Wada, K; Yamagata, S | 1 |
| Nagai, H; Tanaka, H; Uno, T | 1 |
| Inagaki, N; Kobayashi, J; Nagai, H; Nagao, T; Nakao, T; Tanaka, H; Usami, E; Watanabe, S; Yamazaki, F; Yoshimura, T | 1 |
| Arner, P; Degerman, E; Enoksson, S; Hagström-Toft, E; Large, V | 1 |
| Anderson, R; Feldman, C; Goolam Mahomed, A; Ramafi, G; Theron, AJ | 1 |
| Benjamin, AR; Stephens, RH; Walters, DV | 1 |
| Boichot, E; Escofier, N; Germain, N; Lagente, V; Martins, MA; Silva, PM | 1 |
| Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M | 1 |
| Sadan, G; Usta, C | 1 |
| Dent, G; Djukanović, R; Hidi, R; Holgate, ST; Liu, E; Schudt, C; Timmermans, S | 1 |
| Dal Piaz, V; Giovannoni, MP | 1 |
| Chambers, DJ; Featherstone, RL; Kelly, FJ | 1 |
| Landells, LJ; O'Connor, BJ; Page, CP; Souness, JE; Spina, D | 1 |
| Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N | 1 |
| Jain, NK; Kulkarni, SK; Kumar, A | 1 |
| Ezeamuzie, CI | 1 |
| Bardou, M; Dumas, J; Dumas, M; Goirand, F; Rochette, L | 1 |
| Allen, JM; Banner, KH; Doherty, A; Jones, NA; Landells, LJ; O'Connor, BJ; Page, CP; Spina, D; Szilagy, CM | 1 |
| Cunningham, FM; Lees, P; Page, CP; Rickards, KJ | 1 |
| Hasegawa, T; Hiramatsu, K; Ito, Y; Kitaichi, K; Kume, H; Shibata, E; Shimizu, Y; Suzuki, R; Takagi, K; Takeuchi, M; Yamaki, K; Yoshida, N | 1 |
| Baba, K; Hasegawa, T; Kitaichi, K; Miyamoto, K; Shibata, E; Suzuki, R; Takagi, K; Takeuchi, M; Tatsumi, Y | 1 |
| Chen, JC; Chen, JQ; Chen, Z; Wang, K | 1 |
| Chung, KF; Huang, KH; Kuo, HP; Lin, CH; Lin, HC; Liu, SL; Wang, CH; Yu, CT | 1 |
| Choo, JH; Kikuchi, I; Nagata, M; Sakamoto, Y; Sutani, A | 1 |
| Devillier, P | 1 |
| Vignola, AM | 1 |
| Sadan, G; Tuncel, B; Usta, C | 1 |
| Kondo, Y; Morishima, T; Tsuge, M; Wada, T; Yashiro, M; Yasui, K | 1 |
| Ballanyi, K; Ruangkittisakul, A | 1 |
| Falkay, G; Gáspár, R; Klukovits, A; Verli, J | 1 |
| Kim, HM; Lee, GH; Lee, JW; Lee, MS; Moon, EY | 1 |
| Ducza, E; Falkay, G; Gáspár, R; Hajagos-Tóth, J; Klukovits, A; Kormányos, Z; Seres, AB; Verli, J | 1 |
| Chłoń-Rzepa, G; Sapa, J; Zygmunt, M | 1 |
5 review(s) available for theophylline and rolipram
| Article | Year |
|---|---|
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity | 1985 |
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive | 2008 |
Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Arthritis, Rheumatoid; Asthma; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Isoenzymes; Lung Diseases, Obstructive; Molecular Structure; Phosphodiesterase Inhibitors; Quinazolines; Rolipram; Theophylline; Xanthines | 2000 |
[Physiopathology of COPD: choosing the right therapeutic targets].
Topics: Adrenal Cortex Hormones; Aged; Albuterol; Animals; Bacterial Infections; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Therapy, Combination; Humans; Inflammation; Mucociliary Clearance; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Randomized Controlled Trials as Topic; Rats; Rolipram; Salmeterol Xinafoate; Smoking; Theophylline; Time Factors | 2003 |
PDE4 inhibitors in COPD--a more selective approach to treatment.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Benzamides; Bronchodilator Agents; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Nitriles; Phosphodiesterase Inhibitors; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rolipram; Theophylline; Treatment Outcome | 2004 |
72 other study(ies) available for theophylline and rolipram
| Article | Year |
|---|---|
New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones.
Topics: Animals; Bronchodilator Agents; Drug Interactions; Guinea Pigs; Imidazoles; Male; Mice; Muscle Relaxation; Muscle, Smooth; Naphthyridines; Phosphodiesterase Inhibitors; Structure-Activity Relationship; Trachea | 1992 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Depression, Chemical; Heart; Isoenzymes; Male; Models, Chemical; Muscle Relaxation; Myocardium; Phosphodiesterase Inhibitors; Purines; Shrews; Trachea | 1997 |
PDE4 inhibitors: new xanthine analogues.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Eosinophilia; Ferrets; Guinea Pigs; Phosphodiesterase Inhibitors; Skin Diseases; Theophylline; Vomiting; Xanthines | 1998 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanes; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 7; Dose-Response Relationship, Drug; Drug Design; Endotoxemia; Humans; Hydrazines; Lipopolysaccharides; Male; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Structure-Activity Relationship | 2018 |
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram | 2019 |
[Specific inhibition by ATP of histamine-stimulated acid secretion in the gastric glands of the rabbit].
Topics: Adenosine Triphosphate; Animals; Bucladesine; Carbachol; Depression, Chemical; Female; Gastric Acid; Gastric Mucosa; Histamine; Histamine Antagonists; Indomethacin; Male; Prostaglandins; Pyrrolidinones; Rabbits; Rolipram; Secretory Rate; Theophylline | 1992 |
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Chloride; Calmodulin; Chromatography, Ion Exchange; Cyclic GMP; Cytosol; Dipyridamole; Heart Atria; Heart Ventricles; Kinetics; Myocardium; Papaverine; Purinones; Pyrrolidinones; Rana esculenta; Rana ridibunda; Rolipram; Substrate Specificity; Theophylline | 1992 |
Rolipram inhibits PAF-induced airway microvascular leakage in guinea-pig: a comparison with milrinone and theophylline.
Topics: Animals; Capillary Permeability; Evans Blue; Guinea Pigs; Milrinone; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyridones; Pyrrolidinones; Respiratory System; Rolipram; Theophylline | 1992 |
Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Albuterol; Animals; Calcium; Carbachol; Cattle; Colforsin; Cyclic AMP; Drug Interactions; In Vitro Techniques; Inositol Phosphates; Male; Membrane Lipids; Muscle, Smooth; Phospholipids; Purinones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1990 |
Inhibitors of phosphodiesterase III block stimulation of Xenopus laevis oocyte ribosomal S6 kinase activity by insulin-like growth factor-I.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cricetinae; Female; Insulin-Like Growth Factor I; Meiosis; Oocytes; Oogenesis; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyridazines; Pyrrolidinones; Ribosomal Protein S6 Kinases; Rolipram; Theophylline; Xenopus laevis | 1991 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines | 1990 |
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone and Bones; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Indomethacin; Kinetics; Lysosomes; Mice; Parathyroid Hormone; Prostaglandins E; Pyrrolidinones; Rolipram; Theophylline | 1986 |
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bone Resorption; Calcium; Cells, Cultured; Cholera Toxin; Cyclic AMP; Hydrocortisone; Indomethacin; Meclofenamic Acid; Mice; Mice, Inbred Strains; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Skull; Theophylline | 1988 |
A comparison of the inotropic activity of Org 30029, IBMX, milrinone and rolipram in rat papillary muscles.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cardiotonic Agents; In Vitro Techniques; Milrinone; Myocardial Contraction; Organic Chemicals; Papillary Muscles; Pyridones; Pyrrolidinones; Rats; Rolipram; Theophylline | 1989 |
Characterization of adenosine receptors in bone. Studies on the effect of adenosine analogues on cyclic AMP formation and bone resorption in cultured mouse calvaria.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bone and Bones; Bone Resorption; Cells, Cultured; Colforsin; Cyclic AMP; Mice; Phenylisopropyladenosine; Pyrrolidinones; Receptors, Cyclic AMP; Rolipram; Theophylline | 1987 |
Evidence for an A2 adenosine receptor in guinea pig lung.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Ligands; Lung; Membranes; Pyrrolidinones; Receptors, Cell Surface; Receptors, Purinergic; Rolipram; Theophylline; Time Factors | 1985 |
Effects of N6-(L-phenylisopropyl)adenosine, caffeine, theophylline and rolipram on the acquisition of conditioned responses in the rabbit.
Topics: Adenosine; Animals; Caffeine; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Phenylisopropyladenosine; Pyrrolidinones; Rabbits; Rolipram; Theophylline | 1987 |
Endogenous adenosine as a modulator of hippocampal acetylcholine release.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenosine; Animals; Caudate Nucleus; Dipyridamole; Electric Stimulation; Hippocampus; In Vitro Techniques; Pyrrolidinones; Rabbits; Receptors, Cell Surface; Receptors, Purinergic; Rolipram; Theophylline | 1984 |
Adenosine receptor mediated inhibition of noradrenaline release from slices of the rat hippocampus.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Dipyridamole; Electric Stimulation; Hippocampus; Male; Norepinephrine; Phenylisopropyladenosine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Rolipram; Theophylline; Xanthines | 1984 |
Adenosine analogues stimulate cyclic AMP-accumulation in cultured neuroblastoma and glioma cells.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Cell Line; Cells, Cultured; Cyclic AMP; Glioma; Humans; Kinetics; Neuroblastoma; Phenylisopropyladenosine; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Theophylline; Vasodilator Agents | 1984 |
Adenosine antagonism and related effects of theophylline derivatives in guinea pig ileum longitudinal muscle.
Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Animals; Atropine; Choline; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Pyrrolidinones; Rolipram; Synaptic Transmission; Tetrodotoxin; Theophylline | 1984 |
Effects of cyclic AMP- and cyclic GMP- phosphodiesterase inhibitors on immunological release of histamine and on lung contraction.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aza Compounds; Cromolyn Sodium; Cyclic AMP; Cyclic GMP; Cyclopentanes; Histamine Release; Humans; In Vitro Techniques; Lung; Male; Papaverine; Purinones; Pyrrolidinones; Rats; Rolipram; Theophylline | 1981 |
The stimulatory action of phosphodiesterase inhibitors on the flexor reflex of the hind limb in the spinal rat.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Drug Interactions; Male; Phenoxybenzamine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Reflex; Rolipram; Spinal Cord; Theophylline | 1982 |
Regulation of thymocyte proliferation: effects of L-alanine, adenosine and cyclic AMP in vitro.
Topics: Adenosine; Adenosine Deaminase; Alanine; Animals; Cell Division; Cyclic AMP; Cyclopentanes; Guinea Pigs; Kinetics; Male; Mitosis; Pyrrolidinones; Rolipram; T-Lymphocytes; Theophylline | 1981 |
Theophylline interferes with the modulatory role of endogenous adenosine on cholinergic neurotransmission in guinea pig ileum.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cholinergic Fibers; Cyclopentanes; Dilazep; Dipyridamole; Guinea Pigs; Ileum; Male; Muscle Contraction; Nucleosides; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Synaptic Transmission; Theophylline | 1981 |
On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat.
Topics: Adenosine; Animals; Apomorphine; Brain; Drug Synergism; Male; Motor Activity; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Rotation; Theophylline; Xanthines | 1983 |
Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Benzamides; Blood Proteins; Cell Separation; Complement C5a; Cyclic Nucleotide Phosphodiesterases, Type 4; Electromagnetic Fields; Eosinophil Granule Proteins; Eosinophil-Derived Neurotoxin; Eosinophils; Humans; Inflammation Mediators; Luminescent Measurements; Naphthyridines; Neurotoxins; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridines; Pyrrolidinones; Ribonuclease, Pancreatic; Ribonucleases; Rolipram; Theophylline | 1995 |
Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Dogs; Humans; Isoenzymes; Phosphodiesterase Inhibitors; Purinergic Antagonists; Pyrrolidinones; Rats; Receptors, Purinergic; Rolipram; Theophylline; Xanthines | 1993 |
Asthma and airway inflammation: potential anti-inflammatory activities of phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Airway Resistance; Animals; Anti-Inflammatory Agents; Asthma; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Eosinophils; Guinea Pigs; Humans; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Theophylline | 1995 |
Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Hypersensitivity; Inflammation; Injections, Intraperitoneal; Isoenzymes; Macrophages; Male; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Specific Pathogen-Free Organisms; Theophylline; Thiazoles | 1995 |
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Female; Guinea Pigs; Humans; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Middle Aged; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Theophylline; Xanthines | 1993 |
Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs.
Topics: Aminophylline; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Histamine Antagonists; Isoenzymes; Lung; Male; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyrrolidinones; Rolipram; SRS-A; Theophylline | 1993 |
Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits.
Topics: Airway Resistance; Alternaria; Animals; Anti-Inflammatory Agents; Antigens, Fungal; Asthma; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Female; Histamine; Leukocyte Count; Lung Compliance; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rabbits; Respiratory Hypersensitivity; Rolipram; Theophylline | 1996 |
In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Bronchodilator Agents; Cloning, Molecular; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Eosinophils; Guinea Pigs; Humans; Isoenzymes; Kinetics; Monocytes; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrimidinones; Pyrrolidinones; Rats; Receptors, Purinergic P1; Rolipram; Substrate Specificity; Superoxides; Theophylline | 1996 |
Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bronchodilator Agents; Chemotaxis, Leukocyte; Complement C5a; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Activation; Eosinophils; Humans; Hypersensitivity, Immediate; In Vitro Techniques; Leukotriene C4; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Rolipram; Theophylline | 1996 |
Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea pig isolated trachea.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Albuterol; Animals; Drug Synergism; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Osmolar Concentration; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1996 |
Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bronchoconstrictor Agents; Bronchodilator Agents; Guanidines; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Leukotriene C4; Male; Milrinone; Muscle Tonus; Ovalbumin; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1996 |
Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bucladesine; Cell Survival; Cyclic AMP; Dose-Response Relationship, Drug; fas Receptor; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Humans; Interleukin-5; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Proto-Oncogene Proteins c-bcl-2; Pyrrolidinones; Rolipram; Theophylline | 1997 |
Effects of chronic caffeine administration on respiration and schedule-controlled behavior in rhesus monkeys.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Female; Macaca mulatta; Male; Pyrrolidinones; Respiration; Rolipram; Theophylline | 1997 |
Bronchial anti-spasmogenic effects and selectivity of T-440, phosphodiesterase type 4 inhibitor, in the dog.
Topics: Animals; Blood Pressure; Bronchial Spasm; Bronchoconstriction; Chromatography, High Pressure Liquid; Dogs; Female; Guinea Pigs; Heart Rate; Hemodynamics; Histamine; Isoenzymes; Male; Naphthalenes; Parasympatholytics; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram; Theophylline | 1997 |
Effects of isoenzyme selective phosphodiesterase inhibitors on bacterial lipopolysaccharide-induced bronchial hyperreactivity in guinea pigs.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cilostazol; Guinea Pigs; Isoenzymes; Lipopolysaccharides; Male; Neutrophils; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha | 1998 |
Modulation of Th1- and Th2-like cytokine production from mitogen-stimulated human peripheral blood mononuclear cells by phosphodiesterase inhibitors.
Topics: Adrenergic beta-Agonists; Bucladesine; Humans; In Vitro Techniques; Interferon-gamma; Interleukins; Leukocytes, Mononuclear; Milrinone; Mitogens; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram; Th1 Cells; Th2 Cells; Theophylline | 1998 |
Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man.
Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Amrinone; Blood Glucose; Dialysis Solutions; Dipyridamole; Ethanol; Female; Glycerol; Humans; Hypoglycemic Agents; Insulin; Isoenzymes; Lipolysis; Male; Middle Aged; Muscle, Skeletal; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Regional Blood Flow; Rolipram; Sterol Esterase; Theophylline; Vasodilator Agents | 1998 |
Effect of rolipram and dibutyryl cyclic AMP on resequestration of cytosolic calcium in FMLP-activated human neutrophils.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Bucladesine; Calcium; Calcium Radioisotopes; Cytosol; Fluorescent Dyes; Fura-2; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Superoxides; Theophylline | 1998 |
The regulation of lung liquid absorption by endogenous cAMP in postnatal sheep lungs perfused in situ.
Topics: Absorption; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Bucladesine; Cyclic AMP; Lung; Osmotic Pressure; Perfusion; Phosphodiesterase Inhibitors; Purinergic Antagonists; Pyrrolidinones; Rolipram; Sheep; Sotalol; Theophylline | 1998 |
Effects of interleukin-10 and modulators of cyclic AMP formation on endotoxin-induced inflammation in rat lung.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Animals; Bronchoalveolar Lavage Fluid; Bucladesine; Cell Count; Cyclic AMP; Dose-Response Relationship, Drug; Endotoxins; Free Radical Scavengers; Inflammation; Interleukin-10; Lipopolysaccharides; Luminescent Measurements; Luminol; Lung; Male; Neutrophils; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Salmeterol Xinafoate; Superoxide Dismutase; Theophylline; Tumor Necrosis Factor-alpha; Zymosan | 1999 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
Comparison of the effects of selective III, IV and nonselective phosphodiesterase inhibitors on isolated tracheal preparations in streptozotocin-diabetic rats.
Topics: Amrinone; Animals; Carbachol; Cardiotonic Agents; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Muscle Contraction; Muscle Relaxation; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Rolipram; Streptozocin; Theophylline; Trachea | 2000 |
Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis.
Topics: Albuterol; Asthma; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Humans; Interleukin-8; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Activating Factor; Rolipram; T-Lymphocytes; Theophylline | 2000 |
Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas' hospital cardioplegic solution used for hypothermic preservation of rat lungs.
Topics: Animals; Bicarbonates; Calcium Chloride; Hypothermia, Induced; Lung; Lung Transplantation; Magnesium; Milrinone; Oxygen; Phosphodiesterase Inhibitors; Potassium Chloride; Pulmonary Gas Exchange; Purinones; Rats; Rats, Wistar; Reperfusion Injury; Rolipram; Sodium Chloride; Theophylline; Vascular Resistance | 2000 |
A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Asthma; Case-Control Studies; Guanidines; Humans; Middle Aged; Monocytes; Phosphodiesterase Inhibitors; Pyridazines; Rolipram; Theophylline; Tumor Necrosis Factor-alpha | 2000 |
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzamides; Bronchi; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glycoproteins; Histamine; Humans; In Vitro Techniques; Leukotriene C4; Lung Neoplasms; Muscle Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridines; Rolipram; Theophylline | 2000 |
Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Evaluation, Preclinical; Drug Synergism; Edema; Female; Male; Mice; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rolipram; Sulfonamides; Theophylline | 2000 |
Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Albuterol; Benzamides; Cell Degranulation; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Eosinophil Peroxidase; Eosinophils; Histamine; Humans; Nitriles; Peroxidases; Phosphodiesterase Inhibitors; Pyridines; Rolipram; Superoxides; Theophylline | 2001 |
Effects of phosphodiesterase inhibitors on hypoxic pulmonary vasoconstriction. Influence of K(+) channels and nitric oxide.
Topics: 4-Aminopyridine; Animals; Apamin; Charybdotoxin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Potassium Channels; Purinones; Rats; Rats, Wistar; Rolipram; Theophylline; Vasoconstriction | 2001 |
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adolescent; Adult; Allergens; Asthma; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Leukocytes, Mononuclear; Male; Phosphodiesterase Inhibitors; Phytohemagglutinins; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Rolipram; Theophylline | 2001 |
Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors.
Topics: Animals; Cell Adhesion; Cells, Cultured; Horse Diseases; Horses; Lung Diseases, Obstructive; Neutrophils; Phosphodiesterase Inhibitors; Rolipram; Superoxides; Theophylline | 2001 |
Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells.
Topics: Adult; Asthma; Cilostazol; Colforsin; Cyclic AMP; Dexamethasone; Humans; In Vitro Techniques; Interleukin-13; Kinetics; Leukocytes, Mononuclear; Male; Phosphodiesterase Inhibitors; Phytohemagglutinins; Rolipram; Tetrazoles; Theophylline | 2001 |
Selective phosphodiesterase type 4 inhibitors reduce the prolonged survival of eosinophils stimulated by granulocyte-macrophage colony-stimulating factor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Survival; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Phosphodiesterase Inhibitors; Purines; Rolipram; Theophylline | 2002 |
Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression; Humans; Phosphodiesterase Inhibitors; Rolipram; Saccharomyces cerevisiae; Theophylline; Transfection | 2002 |
Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma.
Topics: Albuterol; Animals; Antigens, CD34; Apoptosis; Asthma; Cell Division; Female; Humans; Male; Methacholine Chloride; Phosphodiesterase Inhibitors; Rolipram; Stem Cells; Theophylline; Time Factors | 2003 |
Theophylline attenuates the adhesion of eosinophils to endothelial cells.
Topics: Adult; Asthma; Bronchodilator Agents; Cell Adhesion; Cyclic AMP; Endothelium, Vascular; Eosinophils; Female; Humans; Intercellular Adhesion Molecule-1; Interleukin-4; Interleukin-5; Male; N-Formylmethionine Leucyl-Phenylalanine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rolipram; Theophylline; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2003 |
The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Isoenzymes; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rolipram; Theophylline; Trachea | 2004 |
Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Adult; Apoptosis; Caspase 3; CD11c Antigen; Cell Differentiation; Dendritic Cells; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Interleukin-4; Male; Monocytes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptors, Purinergic P1; Recombinant Proteins; RNA, Small Interfering; Rolipram; Theophylline; Xanthines | 2009 |
Methylxanthine reversal of opioid-evoked inspiratory depression via phosphodiesterase-4 blockade.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analgesics, Opioid; Animals; Animals, Newborn; Caffeine; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; In Vitro Techniques; Interneurons; Nerve Net; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, mu; Respiratory Insufficiency; Respiratory Physiological Phenomena; Rolipram; Theophylline; Xanthines | 2010 |
Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: studies on pregnant rat uteri in vitro.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Cyclic AMP; Drug Synergism; Female; Lipopolysaccharides; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pregnancy; Premature Birth; Rats; Rats, Sprague-Dawley; Rolipram; Terbutaline; Theophylline; Time Factors; Uterine Contraction; Uterus | 2010 |
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glioblastoma; Guanine Nucleotide Exchange Factors; Humans; Isoquinolines; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Rolipram; Shelterin Complex; Signal Transduction; Sulfonamides; Telomere-Binding Proteins; Theophylline | 2012 |
Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: studies on pregnant rat in vivo and on pregnant human myometrium in vitro.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Humans; Myometrium; Obstetric Labor, Premature; Phosphodiesterase Inhibitors; Pregnancy; Premature Birth; Rats; Rats, Sprague-Dawley; Rolipram; Terbutaline; Theophylline; Uterine Contraction; Uterus | 2013 |
Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Formaldehyde; Purines; Rolipram; Theophylline | 2014 |