theophylline has been researched along with probenecid in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (40.63) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 6 (18.75) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Moghadam, B; Ryan, WJ; Wells, H; Yu, JH | 1 |
| Acara, M; Carr, EA; Terry, EN | 1 |
| Spector, R | 1 |
| Anderson, DA; Batra, KK; Kurland, G; Marquardt, ED; Mitsuoka, JC | 1 |
| Chiu, PJ; Dantzler, WH; Sawyer, WH; Shaffner, DP | 1 |
| Manganiello, V; Murad, F; Vaughan, M | 1 |
| Bourguet, J; Parisi, M; Ripoche, P | 1 |
| Paalzow, G; Paalzow, L | 1 |
| Arbin, A; Edlund, PO | 1 |
| Kolassa, N; Pfleger, K; Volkmer, I | 1 |
| Bartfai, T; Lazaridis, G; Tjörnhammar, ML | 1 |
| Jarboe, CH; May, DC | 2 |
| Goriki, K; Ochiai, M; Okusaki, K; Takahashi, H; Toda, K; Tokunou, H; Uehara, S | 1 |
| Kildalsen, H; Sager, G; Schultz, C; Vaskinn, S | 1 |
| Florio, C; Frausin, F; Gaion, RM; Vertua, R | 1 |
| Kuh, HJ; Shim, CK | 1 |
1 review(s) available for theophylline and probenecid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
31 other study(ies) available for theophylline and probenecid
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Cyclic AMP formation and release by cultured bone cells stimulated with prostaglandin E2.
Topics: Animals; Bone and Bones; Cells, Cultured; Culture Media; Cyclic AMP; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinitrophenols; Dose-Response Relationship, Drug; Gallopamil; Ouabain; Probenecid; Prostaglandins E; Theophylline; Time Factors | 1979 |
Probenecid inhibition of the renal excretion of dyphylline in chicken, rat and man.
Topics: Adult; Animals; Carbon Radioisotopes; Chickens; Dyphylline; Half-Life; Humans; Kidney; Male; Metabolic Clearance Rate; Perfusion; Probenecid; Rats; Theophylline | 1987 |
Hypoxanthine transport through the blood-brain barrier.
Topics: Adenine; Animals; Blood-Brain Barrier; Hypoxanthine; Hypoxanthines; Inosine; Leucine; Probenecid; Rats; Rats, Inbred Strains; Theophylline; Thiamine; Uracil | 1987 |
Ineffectiveness of probenecid in theophylline kinetics and excretion.
Topics: Adolescent; Female; Humans; Kinetics; Probenecid; Theophylline | 1985 |
Probenecid inhibition of arginine vasotocin in snakes, frogs, and on frog bladders in vitro.
Topics: Animals; Anura; Biological Transport; Cyclic AMP; Drug Antagonism; Glomerular Filtration Rate; In Vitro Techniques; Peptides; Physiology, Comparative; Pituitary Hormones, Posterior; Probenecid; Receptors, Drug; Snakes; Sodium; Theophylline; Urinary Bladder; Urine; Vasotocin | 1970 |
Effects of guanosine 3',5'-monophosphate on glycerol production and accumulation of adenosine 3',5'-monophosphate by fat cells.
Topics: Adenine Nucleotides; Adipose Tissue; Animals; Cyclic AMP; Epididymis; Epinephrine; Erythrocytes; Glycerol; Guanine Nucleotides; Insulin; Kidney; Liver; Male; Probenecid; Prostaglandins; Rats; Sodium Chloride; Stimulation, Chemical; Theophylline; Tritium | 1970 |
Probenecid: effects on water permeability in frog urinary bladder.
Topics: Animals; Anura; Arginine; Biological Transport; Cyclic AMP; Drug Antagonism; Electric Conductivity; Oxytocin; Permeability; Probenecid; Rana esculenta; Stimulation, Chemical; Theophylline; Urinary Bladder; Vasotocin; Water | 1972 |
Theophylline increased sensitivity to nociceptive stimulation and regional turnover of rat brain 5-HT, noradrenaline and dopamine.
Topics: Animals; Brain Chemistry; Catecholamines; Corpus Striatum; Depression, Chemical; Diencephalon; Dopamine; Electric Stimulation; Indoleacetic Acids; Male; Medulla Oblongata; Mesencephalon; Methyltyrosines; Motor Activity; Norepinephrine; Pons; Probenecid; Rats; Sensation; Serotonin; Stimulation, Chemical; Telencephalon; Theophylline; Time Factors; Vocalization, Animal | 1974 |
Determination of theophylline and probenecid in biological material.
Topics: Animals; Brain Chemistry; Caffeine; Chloroform; Chromatography; Chromatography, Gas; Hydrogen-Ion Concentration; Methods; Probenecid; Solvents; Theobromine; Theophylline; Water | 1974 |
[Inhibition of adenosine uptake and stimulation of its effect on isolated hearts of warm-blooded animals by coronary active substances].
Topics: Alkaloids; Allopurinol; Animals; Carbon Isotopes; Cocaine; Depression, Chemical; Dipyridamole; Drug Synergism; Ethylenediamines; Guinea Pigs; Heart Rate; In Vitro Techniques; Myocardium; Nitroglycerin; Nucleosides; Ouabain; Papaverine; Prenylamine; Probenecid; Pyridines; Reserpine; Stimulation, Chemical; Theophylline; Triamterene; Vasodilator Agents; Verapamil | 1969 |
Cyclic GMP efflux from liver slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Calcium; Cyclic GMP; In Vitro Techniques; Iodoacetamide; Kinetics; Liver; Male; Methylnitronitrosoguanidine; Probenecid; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Effect of probenecid on dyphylline elimination.
Topics: Chromatography, High Pressure Liquid; Drug Interactions; Dyphylline; Female; Humans; Kinetics; Male; Probenecid; Theophylline | 1983 |
Inhibition of clearance of dyphylline by probenecid.
Topics: Dyphylline; Female; Humans; Male; Probenecid; Theophylline | 1981 |
Gout due to xanthine derivatives.
Topics: Allopurinol; Aminophylline; Asthma; Benzbromarone; Bronchodilator Agents; Drug Therapy, Combination; Female; Gout; Humans; Middle Aged; Probenecid; Theophylline; Uric Acid; Uricosuric Agents | 1997 |
Cyclic AMP stimulates the cyclic GMP egression pump in human erythrocytes: effects of probenecid, verapamil, progesterone, theophylline, IBMX, forskolin, and cyclic AMP on cyclic GMP uptake and association to inside-out vesicles.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport, Active; Colforsin; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Erythrocyte Membrane; Humans; Ion Pumps; Probenecid; Progesterone; Theophylline; Verapamil | 1998 |
Involvement of P1 receptors in the effect of forskolin on cyclic AMP accumulation and export in PC12 cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Cyclic AMP; PC12 Cells; Probenecid; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Theophylline; Time Factors | 1999 |
Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats.
Topics: Animals; Biotransformation; Bronchodilator Agents; Infusions, Intravenous; Injections, Intravenous; Male; Nonlinear Dynamics; Probenecid; Rats; Rats, Wistar; Renal Agents; Theophylline; Uric Acid | 1994 |