theophylline and omeprazole

theophylline has been researched along with omeprazole in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.04)	18.7374
1990's	22 (44.90)	18.2507
2000's	11 (22.45)	29.6817
2010's	15 (30.61)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Moncrieff, J; Snyman, JR; Sommers, DK; van Wyk, M	1
Bocquentin, M; Caulin, C; Geneve, J; Simoneau, G; Singlas, E; Taburet, AM	1
Andersson, T; Jonkman, JH; Oosterhuis, B; Zuiderwijk, PB	1
Humphries, TJ	1
Bliesath, H; Hartmann, M; Huber, R; Lührmann, B; Schulz, HU; Steinijans, VW; Wurst, W	2
Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW	2
Chacín, J; Lobo, P; Subero, O	1
Bachmann, KA; Jauregui, L; Levine, L; Miller, K; Reese, J; Sullivan, TJ	1
Bliesath, H; Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW; Wurst, W; Zech, K	1
Roots, I; Rost, KL	1
Chakrabarti, A; Chandrashekhar, SM; Garg, SK	1
Cavanaugh, JH; Granneman, GR; Karol, MD; Locke, CS	1
Kato, S; Okabe, S; Takeuchi, K	1
Ihara, N; Kokufu, T; Koyama, H; Mori, S; Nakajima, K; Ohta, T; Sugioka, N	1
Binkley, SN; Ring, BJ; VandenBranden, M; Wrighton, SA	1
Shimada, T; Yamazaki, H	1
Flockhart, DA; Jang, IJ; Ko, JW; Nam, SK; Shin, JG; Shin, SG	1
Dilger, K; Klotz, U; Zheng, Z	1
Butters, CJ; McKillop, D; Wild, MJ	1
Fask, A; Saltiel, E	1
Bohnemeier, H; Brockmöller, J; Fuhr, U; Roots, I; Rost, KL; Thomsen, T; Zaigler, M	1
Goldwater, DR; Hunt, RH; Pan, WJ; Pilmer, BL; Zhang, Y	1
Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M	1
Onur, R; Yenisehirli, A	1
Chadwick, LR; Guo, J; Nikolic, D; Pauli, GF; van Breemen, RB	1
Calafat, AM; Hauser, R; Hernández-Díaz, S; Kelley, KE; Mitchell, AA	1
Farid, NA; Hagihara, K; Ikeda, T; Ishizuka, T; Kazui, M; Kurihara, A; Nishiya, Y; Okazaki, O	1
Kim, DH; Oh, KS; Park, SJ; Shin, JG; Shinde, DD	1
Akamatsu, T; Chida, K; Inui, N; Karayama, M; Namiki, N; Tanaka, S; Uchida, S; Watanabe, H	1
Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM	1
Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ	1
Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ	1

Reviews

3 review(s) available for theophylline and omeprazole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole. Digestive diseases and sciences, 1991, Volume: 36, Issue:12 Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin	1991
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994

Trials

12 trial(s) available for theophylline and omeprazole

Article	Year
The effects of omeprazole-induced hypochlorhydria on absorption of theophylline from a sustained-release formulation. European journal of clinical pharmacology, 1992, Volume: 43, Issue:2 Topics: Achlorhydria; Adult; Delayed-Action Preparations; Gastrointestinal Transit; Humans; Intestinal Absorption; Male; Omeprazole; Tablets; Theophylline	1992
Theophylline steady state pharmacokinetics is not altered by omeprazole. European journal of clinical pharmacology, 1992, Volume: 42, Issue:3 Topics: Adult; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Interactions; Humans; Male; Omeprazole; Reference Values; Theophylline	1992
No influence of single intravenous doses of omeprazole on theophylline elimination kinetics. Journal of clinical pharmacology, 1992, Volume: 32, Issue:5 Topics: Adult; Drug Interactions; Humans; Injections, Intravenous; Male; Omeprazole; Theophylline	1992
Lack of influence of pantoprazole on the disposition kinetics of theophylline in man. International journal of clinical pharmacology, therapy, and toxicology, 1991, Volume: 29, Issue:9 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Adult; Benzimidazoles; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Omeprazole; Pantoprazole; Sulfoxides; Theophylline; Time Factors	1991
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994
Pharmacokinetic interaction between lansoprazole and theophylline. Therapeutic drug monitoring, 1995, Volume: 17, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Administration, Oral; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Half-Life; Humans; Lansoprazole; Male; Omeprazole; Proton Pump Inhibitors; Theophylline	1995
Lack of influence of pantoprazole on the disposition kinetics of theophylline in man. International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:1 Suppl Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Area Under Curve; Benzimidazoles; Bronchodilator Agents; Cross-Over Studies; Drug Interactions; Enzyme Inhibitors; Half-Life; Humans; Infusions, Intravenous; Male; Omeprazole; Pantoprazole; Proton Pump Inhibitors; Sulfoxides; Theophylline	1996
Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers. Clinical pharmacology and therapeutics, 1999, Volume: 65, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Bronchodilator Agents; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Genotype; Humans; Lansoprazole; Male; Mixed Function Oxygenases; Omeprazole; Polymorphism, Genetic; Prospective Studies; Proton Pumps; Reference Values; Single-Blind Method; Theophylline; Time Factors; Volunteers; White People	1999
Lack of drug interaction between omeprazole, lansoprazole, pantoprazole and theophylline. British journal of clinical pharmacology, 1999, Volume: 48, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Area Under Curve; Benzimidazoles; Bronchodilator Agents; Cross-Over Studies; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Interactions; Female; Humans; Lansoprazole; Male; Omeprazole; Pantoprazole; Proton Pump Inhibitors; Sulfoxides; Theophylline	1999
Omeprazole weakly inhibits CYP1A2 activity in man. International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:11 Topics: Adult; Binding, Competitive; Biomarkers; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Omeprazole; Single-Blind Method; Theophylline	1999
Lack of a pharmacokinetic interaction between lansoprazole or pantoprazole and theophylline. Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Anti-Ulcer Agents; Area Under Curve; Benzimidazoles; Biological Availability; Bronchodilator Agents; Delayed-Action Preparations; Drug Interactions; Humans; Lansoprazole; Linear Models; Male; Middle Aged; Omeprazole; Pantoprazole; Proton Pump Inhibitors; Single-Blind Method; Sulfoxides; Theophylline	2000
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects. Journal of clinical pharmacology, 2014, Volume: 54, Issue:4 Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult	2014

Other Studies

35 other study(ies) available for theophylline and omeprazole

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Lack of pharmacokinetic interaction as an equivalence problem. International journal of clinical pharmacology, therapy, and toxicology, 1991, Volume: 29, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Adenosine Triphosphatases; Administration, Oral; Adult; Benzimidazoles; Caffeine; Drug Interactions; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Models, Biological; Omeprazole; Pantoprazole; Pharmacokinetics; Sulfoxides; Theophylline; Therapeutic Equivalency	1991
Ca2+ requirement for metabolic effects of secretagogues in the amphibian gastric mucosa. The American journal of physiology, 1989, Volume: 257, Issue:6 Pt 1 Topics: Acetates; Animals; Anti-Ulcer Agents; Bufo marinus; Butyrates; Butyric Acid; Calcimycin; Calcium; Gastric Juice; Gastric Mucosa; Glycogen; Histamine; Imidazoles; In Vitro Techniques; Kinetics; Omeprazole; Oxygen Consumption; Potassium; Theophylline	1989
Drug interactions of H2-receptor antagonists. Scandinavian journal of gastroenterology. Supplement, 1994, Volume: 206 Topics: Adolescent; Adult; Aged; Antacids; Biological Availability; Cimetidine; Drug Interactions; Famotidine; Histamine H2 Antagonists; Humans; Middle Aged; Nizatidine; Omeprazole; Phenytoin; Ranitidine; Theophylline	1994
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test. Clinical pharmacology and therapeutics, 1994, Volume: 55, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Male; Mephenytoin; Middle Aged; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Theophylline; Uric Acid	1994
Pharmacokinetics of antipyrine and theophylline: unaltered by multi-dose omeprazole treatment in rabbits. Indian journal of physiology and pharmacology, 1995, Volume: 39, Issue:3 Topics: Animals; Antipyrine; Enzyme Inhibitors; Male; Omeprazole; Rabbits; Theophylline	1995
Pathways mediating pentagastrin-induced mucosal blood flow response in rat stomachs. Digestive diseases and sciences, 1996, Volume: 41, Issue:3 Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Drug Interactions; Gastric Acid; Gastric Mucosa; Glycine; Indomethacin; Male; Omeprazole; Pentagastrin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Theophylline	1996
Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. European journal of clinical pharmacology, 1995, Volume: 48, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Bronchodilator Agents; Drug Interactions; Enzyme Inhibitors; Humans; Individuality; Lansoprazole; Male; Omeprazole; Proton Pump Inhibitors; Theophylline	1995
Lack of pharmacokinetic interaction as an equivalence problem. International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:1 Suppl Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Benzimidazoles; Bronchodilator Agents; Drug Interactions; Enzyme Inhibitors; Humans; Omeprazole; Pantoprazole; Pharmaceutical Preparations; Pharmacokinetics; Proton Pump Inhibitors; Research Design; Statistics as Topic; Sulfoxides; Theophylline; Therapeutic Equivalency	1996
Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor. Pharmacogenetics, 1996, Volume: 6, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Kinetics; Liver; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Proton-Translocating ATPases; Rabbits; Rabeprazole; Recombinant Proteins; Sulfaphenazole; Theophylline	1996
Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3 Topics: Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cholecalciferol; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Ethanolamines; Humans; Isoenzymes; Lauric Acids; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Paclitaxel; Prostaglandins; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tretinoin; Warfarin; Xenobiotics	1999
Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:8 Topics: Cimetidine; Clorgyline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Omeprazole; Oxazoles; Oxazolidinones; Recombinant Proteins; Serotonin Receptor Agonists; Theophylline; Tryptamines	1999
Prevalence of potential proton-pump inhibitor drug interactions: a retrospective review of prescriptions in community pharmacies. Clinical therapeutics, 1999, Volume: 21, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Diazepam; Drug Interactions; Enzyme Inhibitors; Humans; Lansoprazole; Omeprazole; Pharmacies; Prevalence; Proton Pump Inhibitors; Retrospective Studies; Theophylline; Warfarin	1999
Rate-limiting biotransformation of triamterene is mediated by CYP1A2. International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:7 Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene	2005
Positive inotropic and negative chronotropic effects of proton pump inhibitors in isolated rat atrium. European journal of pharmacology, 2005, Sep-20, Volume: 519, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Heart Atria; Imidazoles; In Vitro Techniques; Lansoprazole; Male; Milrinone; Myocardial Contraction; Omeprazole; Ouabain; Phosphodiesterase Inhibitors; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Theophylline; Verapamil	2005
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.). Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Dealkylation; Enzyme Inhibitors; Flavanones; Humans; Humulus; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Quercetin; Theophylline; Xanthones	2006
Medications as a potential source of exposure to phthalates in the U.S. population. Environmental health perspectives, 2009, Volume: 117, Issue:2 Topics: Adolescent; Adult; Data Collection; Didanosine; Environmental Exposure; Female; Humans; Male; Mesalamine; Middle Aged; Omeprazole; Pharmaceutical Preparations; Phthalic Acids; Pregnancy; Theophylline; Young Adult	2009
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1 Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine	2010
High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, May-01, Volume: 895-896 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Stability; Humans; Imidazoles; Linear Models; Liquid-Liquid Extraction; Losartan; Omeprazole; Pharmaceutical Preparations; Reproducibility of Results; Tandem Mass Spectrometry; Tetrazoles; Theophylline	2012
Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method. Clinical pharmacology and therapeutics, 2013, Volume: 94, Issue:6 Topics: Adult; Antibiotics, Antitubercular; Asian People; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Imidazoles; Losartan; Male; Midazolam; Omeprazole; Rifampin; Tetrazoles; Theophylline; Time Factors; Withholding Treatment	2013
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress]. Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:3 Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide	2015
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency]. Yao xue xue bao = Acta pharmaceutica Sinica, 2017, Volume: 52, Issue:2 Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency	2017