theophylline and nifedipine

theophylline has been researched along with nifedipine in 85 studies

Research

Studies (85)

TimeframeStudies, this research(%)All Research%
pre-199030 (35.29)18.7374
1990's22 (25.88)18.2507
2000's15 (17.65)29.6817
2010's18 (21.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Andersson, KE; Sjögren, C1
Daniel, EE; Fox, JA1
Bennett, MR; Kerr, R; Khurana, G1
Kawano, N; Ono, J; Takaki, R; Yarimizu, K1
Furukawa, T; Katsuragi, T; Ogawa, S; Shirakabe, K; Soejima, O1
Belonosov, SS; Chel'tsov, VV; Lepakhin, VK; Moiseev, VS; Rubtsova, II; Trufanova, LM1
Canberk, A; Eroğlu, L; Yilmaz, E1
Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT1
Bornemann, M; Hofeldt, FD; Kidd, GS; McDermott, MT; Sjoberg, RJ; Walden, TL1
Adebayo, GI; Mabadeje, AF1
Banditt, P; Köhler, E; Luther, R; Walther, H; Wichert, H1
Hanson, RL; Isaacson, CM1
Lazdunski, M; Renaud, JF; Schmid, A1
Haffner, CA; Kendall, MJ; Smith, SR1
Burks, TF; Fox, DA; Malarchik, ME; Porreca, F; Sheldon, RJ1
Kato, R; Nakaki, T; Sasakawa, N; Yamamoto, S1
Smith, SB1
Kolbeck, RC; Speir, WA1
Christopher, MA; Harman, E; Hendeles, L1
Bergman, B; Fredholm, BB; Lindström, K1
Cheng, H; Cohen, P; Donowitz, M; Elta, G; Levin, S; Powers, G1
Atwater, I; Boschero, AC; Tombaccini, D1
Ciancio, SG1
Kendall, MJ; Skinner, C; Smith, SR; Stableforth, DE; Wiggins, J1
Birkett, DJ; Miners, JO; Robson, RA1
Lalonde, RL; Pieper, JA; Self, TH; Sirmans, SM; Smith, DG1
Knee, CD; Krell, RD; Kusner, EJ1
Davis, C; Kannan, L; Kannan, MS; Ladenius, AR1
Debbas, NM; Jackson, SH; Johnston, A; Peverel-Cooper, CA; Shah, K; Turner, P1
Cohen, E; Garty, M; Ilfeld, DN; Mazar, A; Rosenfeld, JB; Spitzer, S1
Lombardi, C; Spedini, C1
Harrod, CS1
Askar, AO; Mustafa, SJ1
Atanga, GK; Savage, AO1
Endoh, M; Taira, N; Yanagisawa, T1
Andersson, KE; Husted, S; Sjögren, C1
Farah, A; Kabela, E; Mendez, R; Pastelin, G1
Parrillo, SJ; Venditto, M1
Benishin, CG; Lewanczuk, RZ; Pang, PK; Shan, J1
Archer, K; Buchheit, KH; Cook, SJ; Elliott, KR; Foster, RW; Fozard, JR; Martin, A; Miller, AJ; Müller, T; Small, RC1
Bliesath, H; Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW; Wurst, W; Zech, K1
Advenier, C; Brisac, AM; Cortijo, J; Laurent, S; Naline, E; Sarriá, B; Zhang, Y1
Ko, FN; Lin, CH; Lu, ST; Teng, CM; Wu, YC1
Alleva, FR; Balazs, T; Joseph, X; Vick, JA; Whitehurst, VE; Zhang, J1
Barakat, M; du Souich, P1
Fassihi, R; Kim, H1
Dong, MS; Gillam, EM; Guengerich, FP; Johnson, WW; Shimada, T; Yamazaki, H1
Fassihi, R; Pillay, V1
Drabant, S; Farsang, C; Gachályi, B; Klebovich, I; Renczes, G1
Shimada, T; Yamazaki, H1
Fujiwara, K; Hayashi, R; Itoh, M; Kakizawa, H; Kobahashi, T; Makino, M; Mano, T; Nagasaka, A; Nagata, M; Nakai, A; Uchimura, K; Wada, M1
Kokue, E; Saitoh, T; Shimoda, M1
Beraudi, A; Di Iorio, P; Notari, S; Poli, A; Traversa, U; Villani, L; Zaccanti, F1
AL-Shabanah, O; EL-Kashef, H; Khattab, M1
Boerma, M; Hauer-Jensen, M; Joseph, J; Kennedy, RH; Melchert, RB; Owings, R1
Allesø, M; Cornett, C; Rantanen, J; Tian, F1
Biswas, D; Ghosh, M; Mukherjee, A1
Dahlgren, D; Lennernäs, H; Roos, C; Sjögren, E1
Gáspár, R; Hajagos-Tóth, J; Hódi, Á; Seres, AB1
Cruz, A; González-Curbelo, MÁ; León, J; Murcia, H1

Reviews

2 review(s) available for theophylline and nifedipine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Lack of pantoprazole drug interactions in man.
    International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin

1994

Trials

10 trial(s) available for theophylline and nifedipine

ArticleYear
[Asthma of physical effort and the effect of nifedipine and diltiazem].
    Terapevticheskii arkhiv, 1991, Volume: 63, Issue:8

    Topics: Adult; Asthma, Exercise-Induced; Diltiazem; Female; Humans; Male; Nifedipine; Respiratory Function Tests; Theophylline; Time Factors

1991
Nifedipine alters serum theophylline levels in asthmatic patients with hypertension.
    Fundamental & clinical pharmacology, 1991, Volume: 5, Issue:4

    Topics: Adult; Asthma; Blood Pressure; Double-Blind Method; Drug Interactions; Female; Humans; Hypertension; Middle Aged; Nifedipine; Respiratory Function Tests; Theophylline

1991
Effect of nifedipine on antipyrine and theophylline disposition.
    Biopharmaceutics & drug disposition, 1990, Volume: 11, Issue:2

    Topics: Adult; Antipyrine; Drug Interactions; Female; Humans; Male; Microsomes, Liver; Nifedipine; Premedication; Randomized Controlled Trials as Topic; Theophylline

1990
The influence of nifedipine and diltiazem on serum theophylline concentration-time profiles.
    Journal of clinical pharmacy and therapeutics, 1989, Volume: 14, Issue:5

    Topics: Adult; Diltiazem; Drug Interactions; Female; Humans; Male; Nifedipine; Random Allocation; Single-Blind Method; Theophylline

1989
Effect of nifedipine on serum theophylline concentrations and asthma control.
    Thorax, 1987, Volume: 42, Issue:10

    Topics: Aged; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifedipine; Theophylline

1987
Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism: effects on theophylline.
    British journal of clinical pharmacology, 1988, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Humans; Male; Nifedipine; Oxidation-Reduction; Theophylline; Verapamil

1988
Effect of calcium channel blockers on theophylline disposition.
    Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:1

    Topics: Adult; Calcium Channel Blockers; Data Interpretation, Statistical; Diltiazem; Half-Life; Humans; Male; Nifedipine; Random Allocation; Theophylline; Verapamil

1988
Effect of nifedipine and theophylline in asthma.
    Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:2

    Topics: Adult; Aged; Animals; Asthma; Double-Blind Method; Drug Evaluation; Drug Interactions; Humans; Kinetics; Male; Middle Aged; Nifedipine; Peak Expiratory Flow Rate; Random Allocation; Theophylline

1986
Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma.
    European journal of clinical pharmacology, 1986, Volume: 31, Issue:1

    Topics: Aged; Asthma; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifedipine; Respiratory Function Tests; Theophylline

1986
Lack of pantoprazole drug interactions in man.
    International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin

1994

Other Studies

74 other study(ies) available for theophylline and nifedipine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
    Chemical biology & drug design, 2016, Volume: 88, Issue:6

    Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain

2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Inhibition of ATP-induced contraction in the guinea-pig urinary bladder in vitro and in vivo.
    Acta pharmacologica et toxicologica, 1979, Volume: 44, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Amines; Animals; Female; Guinea Pigs; Indomethacin; Isoproterenol; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Parasympatholytics; Propranolol; Tetrodotoxin; Theophylline; Urinary Bladder

1979
Role of Ca2+ in genesis of lower esophageal sphincter tone and other active contractions.
    The American journal of physiology, 1979, Volume: 237, Issue:2

    Topics: Animals; Calcium; Esophagogastric Junction; Ethanol; Female; Lanthanum; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Nifedipine; Nitroprusside; Opossums; Theophylline; Verapamil

1979
Adenosine modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia.
    British journal of pharmacology, 1992, Volume: 106, Issue:1

    Topics: 2-Chloroadenosine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cells, Cultured; Chick Embryo; Electric Conductivity; Ganglia, Parasympathetic; Membrane Potentials; Neurons; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Theophylline; Verapamil

1992
Periodicity of insulin secretion comprises multiple cycles with different duration in perfused rat islets.
    Diabetes research and clinical practice, 1992, Volume: 17, Issue:1

    Topics: Activity Cycles; Animals; Calcimycin; Calcium Channel Blockers; Cells, Cultured; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Nifedipine; Perfusion; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Theophylline

1992
Involvement of dihydropyridine-sensitive Ca2+ channels in adenosine-evoked inhibition of acetylcholine release from guinea pig ileal preparation.
    Journal of neurochemistry, 1990, Volume: 55, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Acetylcholine; Adenosine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Calcium Channels; Chromatography, High Pressure Liquid; Dihydropyridines; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle, Smooth; Nifedipine; Physostigmine; Tetrodotoxin; Theophylline

1990
Characterization of metronidazole metabolism by human liver microsomes.
    Biochemical pharmacology, 1991, Apr-15, Volume: 41, Issue:8

    Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide

1991
The effects of theophylline and nifedipine on corticotropin-stimulated cortisol secretion.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Calcium; Cyclic AMP; Humans; Hydrocortisone; Male; Middle Aged; Nifedipine; Reference Values; Theophylline

1990
[Interactions of theophylline and nifedipine].
    Zeitschrift fur Erkrankungen der Atmungsorgane, 1990, Volume: 174, Issue:2

    Topics: Adult; Delayed-Action Preparations; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypertension, Pulmonary; Lung Diseases, Obstructive; Male; Middle Aged; Nifedipine; Theophylline

1990
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake.
    Diabetes, 1985, Volume: 34, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Diterpenes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Nifedipine; Oxazoles; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide; Verapamil

1985
Short term and long term effects of beta-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle.
    The Journal of biological chemistry, 1985, Oct-25, Volume: 260, Issue:24

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Alprenolol; Animals; Bucladesine; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Chick Embryo; Cyclic AMP; Ion Channels; Isoproterenol; Muscles; Nifedipine; Nitrendipine; Receptors, Nicotinic; Reserpine; Theophylline

1985
Pharmacological characterization of neural mechanisms regulating mucosal ion transport in mouse jejunum.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2

    Topics: Action Potentials; Animals; Atropine; Biological Transport; Carbachol; Dimethylphenylpiperazinium Iodide; Electrolytes; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Myenteric Plexus; Nifedipine; Tetrodotoxin; Theophylline

1989
Stimulation by ATP of inositol trisphosphate accumulation and calcium mobilization in cultured adrenal chromaffin cells.
    Journal of neurochemistry, 1989, Volume: 52, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenal Medulla; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Cytidine Triphosphate; Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Nifedipine; Sugar Phosphates; Theophylline; Uridine Triphosphate

1989
Exercise-induced asthma. Diagnostic clues with recommendation for treatment.
    Postgraduate medicine, 1985, Volume: 77, Issue:8

    Topics: Adrenergic beta-Agonists; Asthma; Asthma, Exercise-Induced; Bronchial Spasm; Cromolyn Sodium; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Nifedipine; Parasympatholytics; Peak Expiratory Flow Rate; Theophylline

1985
Diltiazem, verapamil, and nifedipine inhibit theophylline-enhanced diaphragmatic contractility.
    The American review of respiratory disease, 1989, Volume: 139, Issue:1

    Topics: Animals; Biological Transport; Calcium; Calcium Channel Blockers; Diaphragm; Diltiazem; Male; Muscle Contraction; Nifedipine; Rats; Rats, Inbred Strains; Theophylline; Verapamil

1989
Clinical relevance of the interaction of theophylline with diltiazem or nifedipine.
    Chest, 1989, Volume: 95, Issue:2

    Topics: Adolescent; Adult; Asthma; Diltiazem; Drug Interactions; Drug Therapy, Combination; Humans; Nifedipine; Theophylline

1989
Actions of enprofylline in the rat hippocampus.
    Acta physiologica Scandinavica, 1985, Volume: 123, Issue:2

    Topics: Adenosine; Animals; Bronchodilator Agents; Cyclic AMP; Evoked Potentials; Felodipine; Hippocampus; Isoproterenol; Male; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline; Trifluoperazine; Xanthines

1985
Ca2+ channel blockers stimulate ileal and colonic water absorption.
    Gastroenterology, 1985, Volume: 89, Issue:4

    Topics: Animals; Atropine; Biological Transport; Body Water; Calcium; Calcium Channel Blockers; Carbachol; Chlorides; Colon; Cyclic AMP; Drug Interactions; Ileum; In Vitro Techniques; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Male; Nifedipine; Rabbits; Rats; Rats, Inbred Strains; Sodium; Theophylline; Time Factors; Verapamil

1985
Effects of glucose on insulin release and 86Rb permeability in cultured neonatal and adult rat islets.
    FEBS letters, 1988, Aug-29, Volume: 236, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Cell Membrane Permeability; Cells, Cultured; Glucose; Glyceraldehyde; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Rubidium; Secretory Rate; Theophylline

1988
Drugs in dentistry: Commonly prescribed medications, Part IV.
    Dental management, 1988, Volume: 28, Issue:8

    Topics: Dental Care; Drug Therapy; Humans; Metoprolol; Nifedipine; Ranitidine; Theophylline; Thyroxine

1988
Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat.
    Agents and actions, 1987, Volume: 20, Issue:1-2

    Topics: Animals; Capillary Permeability; Chromones; Dose-Response Relationship, Drug; Indomethacin; Masoprocol; Methysergide; Nifedipine; Phenoxybenzamine; Phospholipid Ethers; Platelet Activating Factor; Pyrilamine; Rats; Theophylline; Thiazoles

1987
Agonist interactions at the calcium pools in skinned and unskinned canine tracheal smooth muscle.
    Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:8

    Topics: Acetylcholine; Animals; Caffeine; Calcium; Dogs; Female; Histamine; In Vitro Techniques; Isometric Contraction; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Serotonin; Theophylline; Trachea

1987
The interaction between i.v. theophylline and chronic oral dosing with slow release nifedipine in volunteers.
    British journal of clinical pharmacology, 1986, Volume: 21, Issue:4

    Topics: Administration, Oral; Adult; Delayed-Action Preparations; Drug Evaluation; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Metabolic Clearance Rate; Nifedipine; Theophylline

1986
Theophylline toxicity and nifedipine.
    Annals of internal medicine, 1987, Volume: 106, Issue:3

    Topics: Aged; Drug Interactions; Female; Humans; Nifedipine; Theophylline

1987
Effect of calcium entry blockers and adenosine on the relaxation of large and small coronary arteries.
    Life sciences, 1986, Mar-10, Volume: 38, Issue:10

    Topics: Adenosine; Animals; Arteries; Calcium Channel Blockers; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; Gallopamil; Lidoflazine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Theophylline

1986
Effect of adenosine 5'triphosphate (ATP) on the isolated rectum of the rainbow lizard Agama agama.
    General pharmacology, 1985, Volume: 16, Issue:3

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Chloride; Carbachol; Dipyridamole; In Vitro Techniques; Lizards; Male; Muscle Contraction; Muscle Relaxation; Nifedipine; Potassium Chloride; Quinidine; Rectum; Theophylline

1985
Dissociation of cyclic AMP and contractile responses to isoprenaline: effects of a dihydropyridine derivative, nicardipine (YC-93), on canine ventricular muscle.
    European journal of pharmacology, 1980, Oct-17, Volume: 67, Issue:2-3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Female; Gallopamil; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Nicardipine; Nifedipine; Papaverine; Pyridines; Theophylline; Vasodilator Agents

1980
Direct effects of adenosine and adenine nucleotides on isolated human urinary bladder and their influence on electrically induced contractions.
    The Journal of urology, 1983, Volume: 130, Issue:2

    Topics: Acetylcholine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Adult; Aged; Atropine; Dipyridamole; Electric Stimulation; Female; Humans; In Vitro Techniques; Indomethacin; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Prostaglandins; Purines; Synaptic Transmission; Theophylline; Urinary Bladder

1983
The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog.
    Life sciences, 1983, Oct-31, Volume: 33, Issue:18

    Topics: Animals; Cardiotonic Agents; Dinitrophenols; Dogs; Heart; Heart Failure; Milrinone; Nifedipine; Papaverine; Pentobarbital; Propranolol; Pyridones; Theophylline

1983
Elevated theophylline blood levels from institution of nifedipine therapy.
    Annals of emergency medicine, 1984, Volume: 13, Issue:3

    Topics: Drug Interactions; Humans; Male; Middle Aged; Nifedipine; Theophylline

1984
Mechanism of the vascular action of parathyroid hypertensive factor.
    Journal of cardiovascular pharmacology, 1994, Volume: 23 Suppl 2

    Topics: Animals; Biological Factors; Blood Pressure; Calcium; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Hemodynamics; In Vitro Techniques; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Second Messenger Systems; Theophylline

1994
Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40.
    British journal of pharmacology, 1995, Volume: 114, Issue:1

    Topics: Animals; Cyclic AMP; Electric Stimulation; Electrophysiology; Female; Guinea Pigs; Imidazoles; Isoproterenol; Male; Nifedipine; Parasympatholytics; Pyrazines; Quinine; Theophylline; Trachea

1995
The nicardipine-isoprenaline interaction in human and guinea-pig isolated airways.
    Fundamental & clinical pharmacology, 1994, Volume: 8, Issue:1

    Topics: Adenosine; Animals; Bronchi; Colforsin; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Humans; Isoproterenol; Male; Muscle Relaxation; Nicardipine; Nifedipine; Nitroprusside; Theophylline; Trachea

1994
The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens.
    European journal of pharmacology, 1993, Jun-11, Volume: 237, Issue:1

    Topics: Alkaloids; Animals; Benzopyrans; Calcium; Calmodulin; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Egtazic Acid; Epithelium; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitroprusside; Phenanthrenes; Plants, Medicinal; Propranolol; Pyrroles; Theophylline; Trachea; Vasodilator Agents

1993
Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats.
    Toxicology, 1996, Jun-17, Volume: 110, Issue:1-3

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Death, Sudden, Cardiac; Diltiazem; Disease Models, Animal; Dogs; Electrocardiography; Female; Heart Rate; Hypotension; Infusions, Intravenous; Injections, Intraperitoneal; Male; Nifedipine; Phosphodiesterase Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Respiration; Theophylline; Verapamil

1996
Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:9

    Topics: Animals; Area Under Curve; Bronchodilator Agents; Calcium Channel Blockers; Cytochrome P-450 Enzyme System; Half-Life; Hypoxia; Inflammation; Irritants; Liver; Male; Malondialdehyde; Nifedipine; Rabbits; Theophylline; Turpentine

1996
Application of binary polymer system in drug release rate modulation. 2. Influence of formulation variables and hydrodynamic conditions on release kinetics.
    Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:3

    Topics: Delayed-Action Preparations; Diltiazem; Kinetics; Lactose; Methylcellulose; Molecular Weight; Nifedipine; Oxazines; Pectins; Prednisolone; Pressure; Solubility; Tablets; Theophylline

1997
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.
    Archives of biochemistry and biophysics, 1997, Jun-15, Volume: 342, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Escherichia coli; Ethanolamines; Humans; Hydroxylation; Mixed Function Oxygenases; Mutation; NADP; Nifedipine; Oxidation-Reduction; Phospholipids; Recombinant Proteins; Testosterone; Theophylline; Tolbutamide; Warfarin

1997
Evaluation and comparison of dissolution data derived from different modified release dosage forms: an alternative method.
    Journal of controlled release : official journal of the Controlled Release Society, 1998, Oct-30, Volume: 55, Issue:1

    Topics: Algorithms; Chemistry, Pharmaceutical; Delayed-Action Preparations; Hypromellose Derivatives; Methylcellulose; Nifedipine; Osmolar Concentration; Solubility; Theophylline

1998
[Role of food interaction pharmacokinetic studies in drug development. Food interaction studies of theophylline and nifedipine retard and buspirone tablets].
    Acta pharmaceutica Hungarica, 1998, Volume: 68, Issue:5

    Topics: Buspirone; Cross-Over Studies; Dietary Fats; Food-Drug Interactions; Humans; Metabolic Clearance Rate; Nifedipine; Postprandial Period; Theophylline

1998
Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3

    Topics: Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cholecalciferol; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Ethanolamines; Humans; Isoenzymes; Lauric Acids; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Paclitaxel; Prostaglandins; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tretinoin; Warfarin; Xenobiotics

1999
Increased urinary phosphate excretion in pseudohypoparathyroidism type II with long-term treatment with phosphodiesterase inhibitor.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1999, Volume: 31, Issue:11

    Topics: Bucladesine; Calcium; Calcium Channel Blockers; Calcium Compounds; Cyclic AMP; Female; Humans; Lactates; Middle Aged; Nifedipine; Phosphates; Phosphodiesterase Inhibitors; Pseudohypoparathyroidism; Theophylline

1999
The impact of acute phase response on the plasma clearance of antipyrine, theophylline, phenytoin and nifedipine in rabbits.
    Journal of veterinary pharmacology and therapeutics, 2000, Volume: 23, Issue:3

    Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antipyrine; Area Under Curve; Chromatography, High Pressure Liquid; Escherichia coli; Female; Half-Life; Injections, Intramuscular; Interleukin-6; Lipopolysaccharides; Metabolic Clearance Rate; Nifedipine; Phenytoin; Protein Binding; Rabbits; Theophylline; Vasodilator Agents

2000
The calcium-dependent [3H]acetylcholine release from synaptosomes of brown trout (Salmo trutta) optic tectum is inhibited by adenosine A1 receptors: effects of enucleation on A1 receptor density and cholinergic markers.
    Brain research, 2001, Feb-16, Volume: 892, Issue:1

    Topics: Acetylcholine; Acetylcholinesterase; Adenosine; Afferent Pathways; Animals; Calcium; Calcium Channel Blockers; Choline O-Acetyltransferase; Kinetics; Membrane Potentials; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Potassium Chloride; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Superior Colliculi; Synaptosomes; Theophylline; Tritium; Trout

2001
Comparative study of the contractile activity evoked by ATP and diadenosine tetraphosphate in isolated rat urinary bladder.
    Pharmacological research, 2002, Volume: 45, Issue:2

    Topics: Adenosine Triphosphate; Animals; Atropine; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Rats; Rats, Wistar; Theophylline; Urinary Bladder

2002
Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:4

    Topics: Acetylcholine; Adenosine; Animals; Anti-Arrhythmia Agents; Atropine; Calcium Channel Blockers; Coronary Circulation; Dose-Response Relationship, Drug; Heart Rate; Homocysteine; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Rats; Rats, Sprague-Dawley; Theophylline; Vasodilation; Vasodilator Agents

2006
Towards effective solid form screening.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:9

    Topics: Crystallization; Drug Compounding; Equipment Design; Miniaturization; Nifedipine; Pharmaceutical Preparations; Theophylline; Vasodilator Agents

2010
High-altitude medicines: a short-term genotoxicity study.
    Toxicology and industrial health, 2010, Volume: 26, Issue:7

    Topics: Acetazolamide; Adult; Altitude Sickness; Analysis of Variance; Cell Survival; Cells, Cultured; Comet Assay; Dexamethasone; DNA; DNA Damage; Furosemide; Humans; Ibuprofen; Lymphocytes; Male; Mutagenicity Tests; Nifedipine; Theophylline

2010
Human in vivo regional intestinal permeability: quantitation using site-specific drug absorption data.
    Molecular pharmaceutics, 2015, Jun-01, Volume: 12, Issue:6

    Topics: Budesonide; Colon; Cyclosporine; Fenofibrate; Humans; Intestinal Absorption; Intestinal Mucosa; Lisdexamfetamine Dimesylate; Metoprolol; Nifedipine; Pyrimidines; Ranitidine; Rivastigmine; Sumatriptan; Terfenadine; Theophylline

2015
Effects of d- and l-limonene on the pregnant rat myometrium in vitro.
    Croatian medical journal, 2015, Volume: 56, Issue:5

    Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cyclic AMP; Cyclohexenes; Female; Indoles; Limonene; Male; Myometrium; Nifedipine; Norepinephrine; Oxidative Stress; Potassium Channel Blockers; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Terpenes; Tetraethylammonium; Theophylline; Uterine Contraction

2015
Study on the inhibitory effect of furafylline and troleandomycin in the 7-methoxyresorufin-O-demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescen
    Journal of pharmaceutical and biomedical analysis, 2019, Feb-05, Volume: 164

    Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Microsomes, Liver; Nifedipine; Oxazines; Poultry; Theophylline; Troleandomycin

2019