Compounds > theophylline

theophylline and nct-501

theophylline has been researched along with nct-501 in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's2 (50.00)2.80

Authors

AuthorsStudies
Brimacombe, K; Ferrer, M; Hu, X; Jadhav, A; Lal-Nag, M; Maloney, DJ; Miller, B; Nguyen, K; Oppermann, U; Simeonov, A; Sun, H; Vasiliou, V; Wang, A; Xu, X; Yang, SM; Yasgar, A1
Chevour, P; Hedne, N; Jayaprakash, A; Kekatpure, V; Kulsum, S; Kuriakose, MA; Mehta, A; Pandian, R; R, N; Ramachandran, B; Ravindra, DR; Sagar, M; Siddappa, G; Sudheendra, HV; Suresh, A1
Backes, FJ; Banerjee, A; Cai, S; Chakravarti, A; Cui, T; Han, C; Liu, L; McLaughlin, E; Wang, QE; Wu, D; Xie, G; Yin, M; Zhang, J; Zhang, X; Zheng, Y1
Guo, D; He, S; Li, L; Peng, J; Wang, W; Xiang, B; Zhang, J; Zhang, R1

Other Studies

4 other study(ies) available for theophylline and nct-501

ArticleYear
Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).
    Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Drug Discovery; Enzyme Inhibitors; Piperazines; Retinal Dehydrogenase; Structure-Activity Relationship; Theophylline

2015
Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition.
    Molecular carcinogenesis, 2017, Volume: 56, Issue:2

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Head and Neck Neoplasms; Humans; Hyaluronan Receptors; Neoplastic Stem Cells; Piperazines; Retinal Dehydrogenase; RNA Interference; RNA, Small Interfering; Squamous Cell Carcinoma of Head and Neck; Theophylline

2017
ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing DNA Repair in BRCA2
    Molecular cancer therapeutics, 2020, Volume: 19, Issue:1

    Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; BRCA2 Protein; Carcinoma, Ovarian Epithelial; Cell Cycle Proteins; Cell Line, Tumor; DNA End-Joining Repair; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Mice; Mice, Nude; Mutation; Nuclear Proteins; Ovarian Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Retinal Dehydrogenase; Theophylline; Transcription Factors; Transfection; Xenograft Model Antitumor Assays

2020
ALDH1A1 maintains the cancer stem-like cells properties of esophageal squamous cell carcinoma by activating the AKT signal pathway and interacting with β-catenin.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125

    Topics: Adult; Aged; Aged, 80 and over; Aldehyde Dehydrogenase 1 Family; Animals; beta Catenin; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplastic Stem Cells; Piperazines; Proto-Oncogene Proteins c-akt; Retinal Dehydrogenase; Signal Transduction; Theophylline

2020