theophylline and n(6)-cyclohexyladenosine

theophylline has been researched along with n(6)-cyclohexyladenosine in 90 studies

Research

Studies (90)

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (33.33)	18.7374
1990's	43 (47.78)	18.2507
2000's	12 (13.33)	29.6817
2010's	5 (5.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jacobson, KA; van Galen, PJ; Williams, M	1
Bey, P; Demeter, DA; Dudley, MW; Lentz, NL; Meng, EC; Ogden, AM; Peet, NP; Weintraub, HJ	1
Daly, JW	1
Gallo-Rodriguez, C; IJzerman, AP; Jacobson, KA; Melman, N; Olah, ME; Stiles, GL; van Bergen, AH; van Galen, PJ	1
Arslan, G; Dionisotti, S; Fredholm, BB; Kull, B; Ongini, E; Zocchi, C	1
Shibata, S; Tominaga, K; Watanabe, S	1
Beckman, B; Brookins, J; Fisher, JW; Nakashima, J	1
Belluco, P; Borea, PA; Dorigo, P; Gaion, RM; Maragno, I; Mosti, L	1
Berman, RF; Jarvis, MF; Lupica, CR	2
Petersen, EN	1
Bealer, SL; Proctor, KG; Stojanov, I	1
Contreras, E; Germany, A	1
Kulkarni, SK; Thorat, SN	1
Fastbom, J; Fredholm, BB	1
Isbrucker, R; Reid, A; Sawynok, J	1
Dragunow, M	1
Aranda, JV; Laudignon, N; Varma, DR	1
Marangos, PJ; von Lubitz, DK	1
Daly, JW; Jacobson, KA; Nikodijević, O	1
Fox, IH; John, D	1
Jackman, SA; Nicholson, CD; Wilke, R	1
Durcan, MJ; Morgan, PF	1
Murray, TF; Sanders, RC	2
Fredholm, BB; Lerner, UH; Sahlberg, K	1
Kurtz, A	1
Churchill, MC; Churchill, PC	1
Daly, JW; Jacobson, KA; Kirk, KL; Padgett, WL	1
Sawynok, J; Sweeney, MI; White, TD	1
Abla, KA; Carney, JM; Daly, JW; Seale, TW; Shamim, MT	1
Kurokawa, M; Tsunoo, A	1
Beckman, B; Brookins, J; Fisher, JW; Ueno, M	1
Harper, AM; McBean, DE; Rudolphi, KA	1
Churchill, PC; Jacobson, KA; Leahy, AE; Rossi, NF	1
Kranzhöfer, R; Mayer, E; Richardt, G; Schömig, A; Waas, W	1
Murray, TF; Sanders, RC; Szot, P	1
Braunwalder, A; Ferkany, JW; Jarvis, MF; Sills, MA; Williams, M	1
Hedner, J; Hedner, T; Holmgren, M; Mellstrand, T; Nordberg, G	1
Furukawa, T; Furuta, K; Harada, T; Katsuragi, T	1
Marangos, PJ; Patel, J; Post, RM; Weiss, SR	1
Collier, HO; Tucker, JF	1
Anderson, SM; Daly, JW; Padgett, W; Weir, RL	1
Furukawa, T; Katsuragi, T; Ushijima, I	1
Plagemann, PG; Wohlhueter, RM	1
Boulenger, JP; Marangos, PJ; Patel, J	1
Butts-Lamb, P; Daly, JW; Padgett, W	1
Corradetti, R; Moroni, F; Passani, MB; Pepeu, G	1
Bristol, JA; Evans, DB; Schenden, JA	1
Adeli, R; Hosseini-semnani, S; Sharifzadeh, M; Zarrindast, MR	1
Modabber, M; Sabetkasai, M; Zarrindast, MR	1
Barnabei, O; Lucchi, R; Poli, A; Traversa, U	1
Daval, JL; Nicolas, F	1
Hornfeldt, CS; Larson, AA	1
Martin, PL; May, JM	1
Nikfar, S; Zarrindast, MR	1
Shafaghi, B; Zarrindast, MR	1
Barrie, AP; Nicholls, DG	1
Lucchi, R; Poli, A; Traversa, U; Zottini, M	1
Bass, BL; Dziki, AJ; Harmon, JW; Pennanen, MF	1
Aoki, M; Mayer, JE; Nomura, F	1
Hsu, SS; Meno, JR; Winn, HR; Zhou, JG	1
Fisher, JW; Nakashima, J; Tazaki, H	1
Shaban, M; Smith, RA; Stone, TW	1
Samini, M; Sharifzadeh, M; Zarrindast, MR	1
Jen, SC; Rovainen, CM	1
Anwer, J; Soliman, MR	1
Moghadamnia, AA; Zarrindast, MR	1
Caruso-Neves, C; Chagas, C; Francisco-Pedro, LG; Lopes, AG; Souza, LP	1
George, B; Kulkarni, SK	1
Birabil, CG; Marks, GA	1
Gandolfi, O; Lucchi, R; Notari, S; Poli, A; Traversa, U; Zampacavallo, G	1
Fredholm, BB; Lindström, K	1
Gouardères, C; Jhamandas, K; Sutak, M; Zajac, JM	1
Shiomi, H; Tamura, Y	1
Homayoun, H; Khavandgar, S; Zarrindast, MR	1
Georgiev, V; Kambourova, T; Tchekalarova, J	1
Fowler, JC; Gervitz, LM; Nalbant, D; Williams, SC	1
Crosson, CE; Shearer, TW	1
Fowler, JC; Gervitz, LM; Hamilton, ME; Lutherer, LO	1
Boyle, DL; Firestein, GS; Moore, J; Sorkin, LS; Yang, L	1
Crosson, CE; Sloan, CF; Yates, PW	1
Fathollahi, Y; Mirnajafi-Zadeh, J; Palizvan, MR; Rezvani, ME	2
Kondo, Y; Morishima, T; Tsuge, M; Wada, T; Yashiro, M; Yasui, K	1
Lazarova, T; Naranjo, AN; O'Malley, MA; Robinson, AS	1
Ciocan, D; Constantinescu, AO; Ilie, A; Moldovan, M; Zagrean, AM; Zagrean, L	1
Drew, KL; Jinka, TR; Tøien, Ø	1
Mansoori, E; Moezi, L; Niknahad, H; Shafaroodi, H	1
Combs, VM; Drew, KL; Jinka, TR	1

Reviews

4 review(s) available for theophylline and n(6)-cyclohexyladenosine

Article	Year
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship	1992
Adenosine receptors: targets for future drugs. Journal of medicinal chemistry, 1982, Volume: 25, Issue:3 Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines	1982
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum. NIDA research monograph, 1984, Volume: 54 Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Morphine; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pertussis Vaccine; Scopolamine; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Yohimbine	1984
[Pharmacological aspects of mammalian hibernation: central thermoregulation factors in hibernation cycle]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 116, Issue:5 Topics: Adenosine; Animals; Body Temperature; Body Temperature Regulation; Central Nervous System; Cricetinae; Hibernation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Thyrotropin-Releasing Hormone	2000

Other Studies

86 other study(ies) available for theophylline and n(6)-cyclohexyladenosine

Article	Year
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors. Journal of medicinal chemistry, 1990, Volume: 33, Issue:12 Topics: Adenosine; Animals; Dogs; Humans; Molecular Conformation; Molecular Structure; Protein Binding; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Xanthines	1990
A binding site model and structure-activity relationships for the rat A3 adenosine receptor. Molecular pharmacology, 1994, Volume: 45, Issue:6 Topics: Adenylyl Cyclase Inhibitors; Animals; Binding Sites; CHO Cells; Cricetinae; Models, Molecular; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship	1994
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. British journal of pharmacology, 1997, Volume: 121, Issue:3 Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Humans; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Species Specificity; Transfection; Triazoles	1997
A neuroprotective effect of adenosine A1-receptor agonists on ischemia-induced decrease in 2-deoxyglucose uptake in rat hippocampal slices. Neuroscience letters, 1992, Sep-28, Volume: 145, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain Ischemia; Deoxyglucose; Hippocampus; In Vitro Techniques; Male; Nervous System Diseases; Phenylisopropyladenosine; Purinergic Antagonists; Rats; Rats, Wistar; Receptors, Purinergic; Theophylline; Vasodilator Agents	1992
Increased erythropoietin secretion in human hepatoma cells by N6-cyclohexyladenosine. The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1 Topics: Adenosine; Anaerobiosis; Bucladesine; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyclic AMP; Erythropoietin; Humans; Hypoxia; Kinetics; Liver Neoplasms; Theophylline	1991
An analysis of the mechanism of the inotropic action of some milrinone analogues in guinea-pig isolated atria. British journal of pharmacology, 1991, Volume: 104, Issue:4 Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Carbachol; Cardiotonic Agents; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Milrinone; Myocardial Contraction; Phenylisopropyladenosine; Propranolol; Pyridones; Reserpine; Theophylline	1991
Chronic theophylline treatment increases adenosine A1, but not A2, receptor binding in the rat brain: an autoradiographic study. Synapse (New York, N.Y.), 1991, Volume: 9, Issue:2 Topics: Adenosine; Animals; Autoradiography; Brain; Male; Phenethylamines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Time Factors; Tissue Distribution	1991
Selective protection by adenosine receptor agonists against DMCM-induced seizures. European journal of pharmacology, 1991, Mar-26, Volume: 195, Issue:2 Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Female; Mice; Pentylenetetrazole; Phenylisopropyladenosine; Receptors, Purinergic; Seizures; Theophylline	1991
Activation of brain adenosine receptors evokes vasodilation in skin arterioles. The American journal of physiology, 1991, Volume: 261, Issue:2 Pt 2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arterioles; Brain; Cricetinae; Injections, Intraventricular; Male; Mesocricetus; Receptors, Purinergic; Skin; Theophylline; Vasodilation; Vasodilator Agents; Xanthines	1991
Adenosine analogs attenuate tolerance-dependence on alprazolam. General pharmacology, 1991, Volume: 22, Issue:4 Topics: Adenosine; Alprazolam; Animals; Drug Tolerance; Male; Mice; Phenylisopropyladenosine; Substance-Related Disorders; Theophylline	1991
Chronic theophylline treatment in vivo increases high affinity adenosine A1 receptor binding and sensitivity to exogenous adenosine in the in vitro hippocampal slice. Brain research, 1991, Feb-22, Volume: 542, Issue:1 Topics: Adenosine; Animals; Drug Resistance; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Time Factors	1991
Effect of MK-801 and its interaction with adenosinergic agents and carbamazepine against hypoxic stress-induced convulsions and death in mice. Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:9 Topics: 2-Chloroadenosine; Adenosine; Animals; Carbamazepine; Dipyridamole; Dizocilpine Maleate; Drug Interactions; Female; Male; Mice; Seizures; Stress, Physiological; Theophylline	1990
Effects of long-term theophylline treatment on adenosine A1-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins. Brain research, 1990, Jan-22, Volume: 507, Issue:2 Topics: Adenosine; Animals; Autoradiography; Brain; GTP-Binding Proteins; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Xanthines	1990
Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord. Brain research, 1990, Aug-06, Volume: 524, Issue:2 Topics: 5,7-Dihydroxytryptamine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Drug Synergism; Hot Temperature; Hydroxydopamines; Male; Methysergide; Norepinephrine; Oxidopamine; Pain; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Serotonin; Spinal Cord; Theophylline	1990
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4 Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines	1990
Effects of adenosine and its analogues on isolated internal carotid arteries from newborn and adult pigs. Biology of the neonate, 1990, Volume: 58, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Animals, Newborn; Carotid Arteries; Dose-Response Relationship, Drug; In Vitro Techniques; Phenylisopropyladenosine; Swine; Theophylline	1990
Cerebral ischemia in gerbils: postischemic administration of cyclohexyl adenosine and 8-sulfophenyl-theophylline. Journal of molecular neuroscience : MN, 1990, Volume: 2, Issue:1 Topics: Adenosine; Animals; Blood Pressure; Brain Ischemia; Drug Interactions; Female; Gerbillinae; Theophylline	1990
Characterization of the locomotor depression produced by an A2-selective adenosine agonist. FEBS letters, 1990, Feb-12, Volume: 261, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Male; Mice; Molecular Structure; Motor Activity; Phenethylamines; Receptors, Purinergic; Theophylline	1990
Characteristics of high affinity and low affinity adenosine binding sites in human cerebral cortex. Advances in experimental medicine and biology, 1986, Volume: 195 Pt B Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Cell Membrane; Cerebral Cortex; Humans; Kinetics; Phenylisopropyladenosine; Receptors, Purinergic; Theophylline	1986
The ability of denbufylline to inhibit cyclic nucleotide phosphodiesterase and its affinity for adenosine receptors and the adenosine re-uptake site. British journal of pharmacology, 1989, Volume: 97, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; Myocardium; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Thioinosine; Xanthines	1989
NECA-induced hypomotility in mice: evidence for a predominantly central site of action. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Central Nervous System; Male; Mice; Motor Activity; Receptors, Purinergic; Theophylline	1989
Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats. Neuroscience letters, 1989, Jul-03, Volume: 101, Issue:3 Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Seizures; Theophylline; Time Factors	1989
Characterization of adenosine receptors in bone. Studies on the effect of adenosine analogues on cyclic AMP formation and bone resorption in cultured mouse calvaria. Acta physiologica Scandinavica, 1987, Volume: 131, Issue:2 Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bone and Bones; Bone Resorption; Cells, Cultured; Colforsin; Cyclic AMP; Mice; Phenylisopropyladenosine; Pyrrolidinones; Receptors, Cyclic AMP; Rolipram; Theophylline	1987
Adenosine stimulates guanylate cyclase activity in vascular smooth muscle cells. The Journal of biological chemistry, 1987, May-05, Volume: 262, Issue:13 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Theophylline; Time Factors	1987
A1 and A2 adenosine receptor activation inhibits and stimulates renin secretion of rat renal cortical slices. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Egtazic Acid; Gallopamil; In Vitro Techniques; Kidney Cortex; Male; Ouabain; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Renin; Theophylline; Vanadates; Vanadium	1985
Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors. Journal of medicinal chemistry, 1985, Volume: 28, Issue:9 Topics: Adenosine; Animals; Cerebral Cortex; Chemical Phenomena; Chemistry; Esterification; Rats; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Xanthenes; Xanthines	1985
Classification of adenosine receptors mediating antinociception in the rat spinal cord. British journal of pharmacology, 1986, Volume: 88, Issue:4 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship, Drug; Male; Pain; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Spinal Cord; Theophylline	1986
3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. Life sciences, 1988, Volume: 43, Issue:21 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Body Temperature; Caffeine; Male; Mice; Mice, Inbred DBA; Motor Activity; Reference Values; Theobromine; Theophylline	1988
Parasympathetic depression of vas deferens contraction in the guinea-pig involves adenosine receptors. The Journal of physiology, 1988, Volume: 407 Topics: Action Potentials; Adenosine; Adenosine Triphosphate; Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Parasympathetic Nervous System; Pelvis; Receptors, Purinergic; Sympathetic Nervous System; Theophylline; Time Factors; Vas Deferens	1988
A1 and A2 adenosine receptor regulation of erythropoietin production. Life sciences, 1988, Volume: 43, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Albuterol; Animals; Erythrocytes; Erythropoietin; Female; Hypoxia; Iron Radioisotopes; Mice; Mice, Inbred ICR; Polycythemia; Receptors, Purinergic; Theophylline	1988
Chronic theophylline exposure increases agonist and antagonist binding to A1 adenosine receptors in rat brain. Neuropharmacology, 1988, Volume: 27, Issue:7 Topics: Adenosine; Animals; Brain; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline	1988
Effects of adenosine and its analogues on porcine basilar arteries: are only A2 receptors involved? Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1988, Volume: 8, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Basilar Artery; Dinoprost; Dose-Response Relationship, Drug; Phenylisopropyladenosine; Prostaglandins F; Receptors, Purinergic; Swine; Theophylline; Vasodilation; Vasodilator Agents	1988
Further characterization of the renovascular effects of N6-cyclohexyladenosine in the isolated perfused rat kidney. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:3 Topics: Adenosine; Animals; In Vitro Techniques; Kidney; Male; Perfusion; Rats; Rats, Inbred Strains; Renal Circulation; Theophylline; Vasoconstriction; Xanthines	1987
Adenosine inhibits exocytotic release of endogenous noradrenaline in rat heart: a protective mechanism in early myocardial ischemia. Circulation research, 1987, Volume: 61, Issue:1 Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Coronary Circulation; Coronary Disease; Disease Models, Animal; Electric Stimulation; Exocytosis; Heart; Male; Myocardium; Norepinephrine; Phenylisopropyladenosine; Rats; Theophylline	1987
Theophylline-induced upregulation of A1-adenosine receptors associated with reduced sensitivity to convulsants. Neuropharmacology, 1987, Volume: 26, Issue:8 Topics: Adenosine; Animals; Convulsants; Drug Tolerance; Kinetics; Male; Mathematics; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline	1987
Biochemical characterization of the antagonist actions of the xanthines, PACPX (1,3-dipropyl-8(2-amino-4-chloro)phenylxanthine) and 8-PT (8-phenyltheophylline) at adenosine A1 and A2 receptors in rat brain tissue. Biochemical pharmacology, 1987, Nov-15, Volume: 36, Issue:22 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; In Vitro Techniques; Kinetics; Rats; Receptors, Purinergic; Theophylline; Xanthines	1987
Characterization of the antinociceptive effects of some adenosine analogues in the rat. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 334, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Dose-Response Relationship, Drug; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Theophylline; Xanthines	1986
A possible explanation for a greater discrepant suppression by adenosine and N6-cyclohexyl adenosine of the guinea-pig ileal contraction. General pharmacology, 1985, Volume: 16, Issue:3 Topics: Adenosine; Animals; Dipyridamole; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Purines; Theophylline	1985
Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine. Neuropharmacology, 1985, Volume: 24, Issue:7 Topics: Adenosine; Animals; Caffeine; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures; Theophylline	1985
Interaction of anticonvulsant drugs with adenosine receptors in the central nervous system. Epilepsia, 1984, Volume: 25, Issue:4 Topics: Adenosine; Animals; Anticonvulsants; Brain; Caffeine; Carbamazepine; Cerebellum; Cerebral Cortex; Cyclic AMP; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline	1984
Involvement of adenosine receptor activities in aggressive responses produced by clonidine in mice. Psychopharmacology, 1984, Volume: 83, Issue:4 Topics: Adenosine; Aggression; Animals; Apomorphine; Bicuculline; Clonidine; Diazepam; Dipyridamole; Humans; Male; Mice; Receptors, Cell Surface; Receptors, Purinergic; Theophylline	1984
Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine. Biochemical pharmacology, 1984, Jun-01, Volume: 33, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Biological Transport, Active; Caffeine; Cell Line; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Papaverine; Phenylisopropyladenosine; Rats; Theophylline; Uridine; Xanthines	1984
Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain. Neuroscience letters, 1982, May-28, Volume: 30, Issue:2 Topics: Adenosine; Binding, Competitive; Brain; Caffeine; Diazepam; Humans; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Purinergic; Theophylline; Xanthines	1982
Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines. Cellular and molecular neurobiology, 1983, Volume: 3, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenylyl Cyclases; Animals; Brain; Caffeine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theobromine; Theophylline; Xanthines	1983
8-Phenyltheophylline potentiates the electrical activity evoked in hippocampal slices. European journal of pharmacology, 1984, Aug-03, Volume: 103, Issue:1-2 Topics: Adenosine; Animals; Corpus Striatum; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Theophylline	1984
Adenosine receptors mediating cardiac depression. Life sciences, 1982, Nov-29, Volume: 31, Issue:22 Topics: 2-Chloroadenosine; Adenosine; Animals; Depression, Chemical; Guinea Pigs; Heart Atria; Male; Myocardial Contraction; Phenylisopropyladenosine; Theophylline; Xanthines	1982
Effects of adenosine receptor agonists and antagonists on physostigmine-induced yawning. European journal of pharmacology, 1995, Mar-24, Volume: 276, Issue:1-2 Topics: Adenosine; Animals; Atropine; Male; Physostigmine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Theophylline; Yawning	1995
Influences of different adenosine receptor subtypes on catalepsy in mice. Psychopharmacology, 1993, Volume: 113, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Catalepsy; Dose-Response Relationship, Drug; Drug Interactions; Mice; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Theophylline; Vasodilator Agents	1993
Functional adenosine A1 receptors in goldfish brain: regional distribution and inhibition of K(+)-evoked glutamate release from cerebellar slices. Neuroscience, 1994, Volume: 58, Issue:2 Topics: Adenosine; Adenylyl Cyclases; Amino Acids; Animals; Calcium; Cerebellum; Colforsin; Cyclic AMP; Glutamates; Glutamic Acid; Goldfish; In Vitro Techniques; Membranes; Potassium; Receptors, Purinergic P1; Theophylline	1994
Opposite effects of cyclohexyladenosine and theophylline on hypoxic damage in cultured neurons. Neuroscience letters, 1994, Jul-04, Volume: 175, Issue:1-2 Topics: Adenosine; Animals; Biological Transport; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Deoxyglucose; Embryo, Mammalian; Kinetics; L-Lactate Dehydrogenase; Neurons; Rats; Theophylline	1994
Adenosine receptors are not involved in theophylline-induced seizures. Journal of toxicology. Clinical toxicology, 1994, Volume: 32, Issue:3 Topics: Adenosine; Animals; Carbamazepine; Dipyridamole; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Receptors, Purinergic P1; Seizures; Theophylline	1994
Identification and functional characterization of A1 and A2 adenosine receptors in the rat vas deferens: a comparison with A1 receptors in guinea pig left atrium and A2 receptors in guinea pig aorta. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3 Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta; Guinea Pigs; Heart; In Vitro Techniques; Male; Norbornanes; Phenethylamines; Rats; Receptors, Purinergic P1; Theophylline; Vas Deferens; Xanthines	1994
Different influences of adenosine receptor agonists and antagonists on morphine antinociception in mice. General pharmacology, 1994, Volume: 25, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dipyridamole; Dose-Response Relationship, Drug; Male; Mice; Morphine; Nociceptors; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P1; Receptors, Purinergic P2; Tail; Theophylline	1994
Effects of adenosine receptor agonists and antagonists on acquisition of passive avoidance learning. European journal of pharmacology, 1994, May-02, Volume: 256, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Avoidance Learning; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Male; Mice; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Theophylline; Vasodilator Agents	1994
Adenosine A1 receptor inhibition of glutamate exocytosis and protein kinase C-mediated decoupling. Journal of neurochemistry, 1993, Volume: 60, Issue:3 Topics: 4-Aminopyridine; Adenosine; Animals; Cerebral Cortex; Enzyme Activation; Exocytosis; Fura-2; Glutamates; Glutamic Acid; Guinea Pigs; Potassium Chloride; Protein Kinase C; Receptors, Purinergic; Synaptosomes; Theophylline	1993
Adenosine A1 receptor-mediated inhibition of evoked glutamate release is coupled to calcium influx decrease in goldfish brain synaptosomes. Brain research, 1993, Aug-27, Volume: 620, Issue:2 Topics: Adenosine; Amino Acids; Animals; Brain; Calcium; Calcium Channel Blockers; Fura-2; Glutamates; Glutamic Acid; Goldfish; Kinetics; omega-Conotoxins; Peptides; Phenylisopropyladenosine; Potassium; Receptors, Purinergic; Synaptosomes; Theophylline	1993
Adenosine: differential effect on blood flow to subregions of the upper gastrointestinal tract. The Journal of surgical research, 1994, Volume: 56, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Duodenum; Esophagus; Gastric Fundus; Gastric Mucosa; Ileum; Inosine; Intestine, Small; Jejunum; Mucous Membrane; Muscle, Smooth; Organ Specificity; Purinergic P1 Receptor Antagonists; Pyloric Antrum; Rabbits; Receptors, Purinergic P1; Regional Blood Flow; Theophylline; Vasodilator Agents	1994
Effects of adenosine infusion during reperfusion after cold cardioplegic ischemia in neonatal lambs. Circulation, 1993, Volume: 88, Issue:5 Pt 2 Topics: Adenosine; Animals; Animals, Newborn; Heart Arrest, Induced; Myocardial Contraction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Receptors, Purinergic P1; Sheep; Theophylline; Ventricular Function, Left	1993
Effects of theophylline and cyclohexyladenosine on brain injury following normo- and hyperglycemic ischemia: a histopathologic study in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1994, Volume: 14, Issue:1 Topics: Adenosine; Animals; Blood Pressure; Brain; Brain Ischemia; Hyperglycemia; Male; Osmolar Concentration; Rats; Rats, Wistar; Reference Values; Theophylline	1994
[Increase in erythropoietin secretion mediated by adenosine A2 receptors]. Human cell, 1993, Volume: 6, Issue:1 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Carcinoma, Hepatocellular; Cell Hypoxia; Cyclic AMP; Erythropoietin; Humans; Liver Neoplasms; Receptors, Purinergic; Theophylline; Tumor Cells, Cultured	1993
Purine suppression of proliferation of Sertoli-like TM4 cells in culture. Cell proliferation, 1995, Volume: 28, Issue:12 Topics: Adenosine; Animals; Caffeine; Cell Division; Cells, Cultured; Male; Mice; Purinergic P1 Receptor Antagonists; Purines; Receptors, Purinergic P1; Sertoli Cells; Theobromine; Theophylline	1995
Effects of adenosine analogues on apomorphine-induced penile erection in rats. General pharmacology, 1995, Volume: 26, Issue:8 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Apomorphine; Male; Penile Erection; Rats; Receptors, Purinergic P1; Theophylline	1995
An adenosine agonist increases blood flow and density of capillary branches in the optic tectum of Xenopus laevis tadpoles. Microcirculation (New York, N.Y. : 1994), 1994, Volume: 1, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Capillaries; Microcirculation; Microscopy, Video; Neovascularization, Physiologic; Nitroglycerin; Regional Blood Flow; Superior Colliculi; Theophylline; Time Factors; Vasodilator Agents; Xenopus laevis	1994
Ethanol-induced alterations in beta-endorphin levels in specific rat brain regions: modulation by adenosine agonist and antagonist. Pharmacology, 1995, Volume: 51, Issue:6 Topics: Adenosine; Animals; beta-Endorphin; Drug Interactions; Ethanol; Frontal Lobe; Hippocampus; Hypothalamus; Injections, Intraperitoneal; Male; Mesencephalon; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Theophylline	1995
Adenosine receptor agents and conditioned place preference. General pharmacology, 1997, Volume: 29, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Mice; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline	1997
Effect of adenosine on the ouabain-insensitive Na+-ATPase activity from basolateral membrane of the proximal tubule. Biochimica et biophysica acta, 1997, Oct-23, Volume: 1329, Issue:2 Topics: Adenosine; Adenosine Triphosphatases; Adenosine-5'-(N-ethylcarboxamide); Animals; Bucladesine; Cation Transport Proteins; Cell Membrane; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Furosemide; Kidney Cortex; Kidney Tubules, Proximal; Kinetics; Ouabain; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Sodium-Potassium-Exchanging ATPase; Swine; Theophylline	1997
Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:5 Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Carbamazepine; Dipyridamole; Disease Models, Animal; Dose-Response Relationship, Drug; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Theophylline; Vasodilator Agents	1997
Enhancement of rapid eye movement sleep in the rat by cholinergic and adenosinergic agonists infused into the pontine reticular formation. Neuroscience, 1998, Volume: 86, Issue:1 Topics: Adenosine; Animals; Atropine; Brain Mapping; Carbachol; Infusions, Parenteral; Male; Microinjections; Muscarinic Antagonists; Pons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Reticular Formation; Sleep; Sleep, REM; Theophylline; Time Factors; Wakefulness	1998
Pharmacological characterization of adenosine A1 receptors and its functional role in brown trout (Salmo trutta) brain. Brain research, 1999, Aug-07, Volume: 837, Issue:1-2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Brain; Cell Membrane; Glutamic Acid; Guanosine Diphosphate; Kinetics; Neuroprotective Agents; Radioligand Assay; Receptors, Purinergic P1; Synaptosomes; Theophylline; Tritium; Trout; Xanthines	1999
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors. European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3 Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines	1999
Role of adenosine in the spinal antinociceptive and morphine modulatory actions of neuropeptide FF analogs. European journal of pharmacology, 2000, Oct-20, Volume: 406, Issue:3 Topics: Adenosine; Analgesics, Opioid; Animals; Male; Morphine; Oligopeptides; Rats; Rats, Sprague-Dawley; Spinal Cord; Theophylline	2000
Effects of adenosine receptor agonists and antagonists on pentylenetetrazole-induced amnesia. European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amnesia; Analysis of Variance; Animals; Avoidance Learning; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Retention, Psychology; Theophylline	2001
Interaction of angiotensin II and III with adenosine A(1) receptor-related drugs in passive avoidance conditioning in rats. Behavioural brain research, 2002, Feb-01, Volume: 129, Issue:1-2 Topics: Adenosine; Angiotensin II; Angiotensin III; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Memory; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline	2002
Adenosine-mediated activation of Akt/protein kinase B in the rat hippocampus in vitro and in vivo. Neuroscience letters, 2002, Aug-09, Volume: 328, Issue:2 Topics: Adenosine; Animals; Cell Death; Cerebrovascular Circulation; Hippocampus; Hypoxia-Ischemia, Brain; Immunohistochemistry; Male; Nerve Degeneration; Neurons; Organ Culture Techniques; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Subcellular Fractions; Synaptic Transmission; Theophylline; Up-Regulation	2002
Adenosine A1 receptor modulation of MMP-2 secretion by trabecular meshwork cells. Investigative ophthalmology & visual science, 2002, Volume: 43, Issue:9 Topics: Adenosine; Animals; Cattle; Cell Line, Transformed; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Time Factors; Trabecular Meshwork	2002
Lack of central effects of peripherally administered adenosine A(1) agonists on synaptic transmission in the rat hippocampus. Brain research, 2002, Sep-27, Volume: 951, Issue:1 Topics: Adenosine; Animals; Cardiovascular Physiological Phenomena; Excitatory Postsynaptic Potentials; Hippocampus; Hypoxia-Ischemia, Brain; Male; Neurons; Neuroprotective Agents; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Synapses; Synaptic Transmission; Theophylline	2002
Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis. Arthritis and rheumatism, 2002, Volume: 46, Issue:11 Topics: Adenosine; Animals; Arthritis, Experimental; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Lew; Receptors, Purinergic P1; Spinal Cord; Theophylline; Transcription Factor AP-1	2002
Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine. Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:10 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anterior Eye Segment; Aqueous Humor; Cattle; Dipeptides; Dose-Response Relationship, Drug; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Protease Inhibitors; Receptor, Adenosine A1; Theophylline; Time Factors	2005
Changes in neuromodulatory effect of adenosine A1 receptors on piriform cortex field potentials in amygdala kindled rats. European journal of pharmacology, 2007, Jun-22, Volume: 565, Issue:1-3 Topics: Adenosine; Amygdala; Animals; Excitatory Postsynaptic Potentials; Kindling, Neurologic; Male; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Seizures; Theophylline	2007
Anticonvulsant effect of A1 but not A2A adenosine receptors of piriform cortex in amygdala-kindled rats. Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amygdala; Analysis of Variance; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Kindling, Neurologic; Male; Microinjections; Models, Anatomic; Phenethylamines; Rats; Rats, Sprague-Dawley; Theophylline; Triazines; Triazoles	2007
Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009, Volume: 39, Issue:12 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Adult; Apoptosis; Caspase 3; CD11c Antigen; Cell Differentiation; Dendritic Cells; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Interleukin-4; Male; Monocytes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptors, Purinergic P1; Recombinant Proteins; RNA, Small Interfering; Rolipram; Theophylline; Xanthines	2009
Analysis of adenosine A₂a receptor stability: effects of ligands and disulfide bonds. Biochemistry, 2010, Nov-02, Volume: 49, Issue:43 Topics: Adenosine; Disulfides; Humans; Ligands; Protein Denaturation; Protein Stability; Receptors, Adenosine A2; Receptors, G-Protein-Coupled; Theophylline	2010
Endogenous adenosine A1 receptor activation underlies the transient post-ischemic rhythmic delta EEG activity. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2011, Volume: 122, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Delta Rhythm; Disease Models, Animal; Electrocardiography; Electroencephalography; Heart Rate; Ischemic Attack, Transient; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Statistics, Nonparametric; Theophylline; Xanthines	2011
Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A(1) receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jul-27, Volume: 31, Issue:30 Topics: Adenosine; Animals; Arctic Regions; Body Temperature; Body Temperature Regulation; Brain; Hibernation; Injections, Intraventricular; Oxygen Consumption; Purinergic Antagonists; Purinergic P1 Receptor Agonists; Receptor, Adenosine A1; Sciuridae; Seasons; Telemetry; Theophylline; Xanthines	2011
The role of alpha-2 adrenoceptors in the anticonvulsant effects of adenosine on pentylenetetrazole-induced seizure threshold in mice. Pharmacology, biochemistry, and behavior, 2014, Volume: 126 Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anticonvulsants; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Pentylenetetrazole; Receptor, Adenosine A1; Receptors, Adrenergic, alpha-2; Seizures; Theophylline; Yohimbine	2014
Translating drug-induced hibernation to therapeutic hypothermia. ACS chemical neuroscience, 2015, Jun-17, Volume: 6, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Body Temperature; CA1 Region, Hippocampal; Cell Death; Disease Models, Animal; Heart Arrest; Heart Rate; Hibernation; Hypothermia, Induced; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Temperature; Theophylline	2015