theophylline and mexiletine

theophylline has been researched along with mexiletine in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (11.54)	18.7374
1990's	11 (42.31)	18.2507
2000's	7 (26.92)	29.6817
2010's	5 (19.23)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Hariya, Y; Hayakawa, H; Inafuku, M; Nagasawa, K; Nakahara, Y; Ohtsu, F; Suzuki, T; Yoshioka, Y	1
Chrymko, MM; Cooper, BE; Kendall, JD	1
Fuhr, U; Roots, I; Rost, KL; Staib, AH	1
Ellison, MJ; Lyman, DJ; San Miguel, E	1
Kawaguchi, Y; Miyai, K; Seki, T; Ueno, K	1
Botteron, GW; Hughes, EM; Hurwitz, A; Jayaraj, A; Sztern, MI; Vacek, JL	1
Loi, CM; Vestal, RE; Wei, XX	1
Destache, CJ; Hilleman, DE; Mohiuddin, SM; Nipper, HC; Stoysich, AM	1
Comer, T; Saliba, D; Stanley, R; Taylor, JL	1
Cox, M; De Marchena, EJ; Interian, A; Kessler, KM; Myerburg, RJ; Topaz, O	1
Buskila, D; Katz, A; Sukenik, S	1
Iwaki, M; Ogiso, T; Uno, S	1
Iwaki, M; Ogiso, T; Okuyama, K; Tanino, T; Uno, S	1
Kobayashi, K; Kuroiwa, Y; Nakajima, M; Shimada, N; Tokudome, S; Yamamoto, T	1
Abolfathi, Z; Beaune, P; Labbé, L; Lessard, E; Pakdel, H; Turgeon, J	1
Carnahan, SL; Hirsh, DA; Hung, I; Lubach, JW; Nagapudi, K; Rossini, AJ; Wijesekara, AV	1

Reviews

1 review(s) available for theophylline and mexiletine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for theophylline and mexiletine

Article	Year
Inhibition of theophylline metabolism by mexiletine in young male and female nonsmokers. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:5 Topics: Adult; Allopurinol; Analysis of Variance; Drug Evaluation; Female; Half-Life; Humans; In Vitro Techniques; Male; Mexiletine; Smoking; Theophylline; Xanthine Oxidase	1991
Influence of mexiletine on the pharmacokinetics of theophylline in healthy volunteers. Journal of clinical pharmacology, 1991, Volume: 31, Issue:4 Topics: Adult; Delayed-Action Preparations; Drug Interactions; Humans; Male; Mexiletine; Theophylline	1991

Other Studies

23 other study(ies) available for theophylline and mexiletine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
[The effect of mexiletine on theophylline pharmacokinetics in patients with bronchial asthma]. Journal of cardiology, 1992, Volume: 22, Issue:1 Topics: Aged; Aged, 80 and over; Asthma; Cardiac Complexes, Premature; Drug Interactions; Female; Humans; Male; Metabolic Clearance Rate; Mexiletine; Middle Aged; Tachycardia, Ventricular; Theophylline	1992
Theophylline-mexiletine interaction: a case report. Pharmacotherapy, 1992, Volume: 12, Issue:5 Topics: Aged; Delayed-Action Preparations; Drug Interactions; Humans; Lung Diseases, Obstructive; Male; Mexiletine; Theophylline	1992
Theophylline metabolism affected by mexiletine. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:1 Topics: Adult; Caffeine; Humans; Male; Mexiletine; Theophylline; Uric Acid; Xanthines	1992
Threefold increase in theophylline serum concentration after addition of mexiletine. The American journal of emergency medicine, 1992, Volume: 10, Issue:5 Topics: Drug Synergism; Drug Therapy, Combination; Heart Failure; Humans; Male; Mexiletine; Middle Aged; Theophylline	1992
Interaction between theophylline and mexiletine. DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:5 Topics: Aged; Asthma; Cardiac Complexes, Premature; Drug Interactions; Heart Block; Humans; Male; Mexiletine; Theophylline	1990
Mexiletine effects on theophylline disposition. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:3 Topics: Adult; Delayed-Action Preparations; Drug Interactions; Humans; Male; Mexiletine; Theophylline; Uric Acid	1991
Mexiletine-theophylline interaction. The American journal of medicine, 1989, Volume: 86, Issue:6 Pt 1 Topics: Aged; Amiodarone; Cardiovascular Diseases; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Lung Diseases, Obstructive; Male; Mexiletine; Theophylline	1989
Proarrhythmia related to a kinetic and dynamic interaction of mexiletine and theophylline. American heart journal, 1989, Volume: 117, Issue:4 Topics: Arrhythmias, Cardiac; Drug Interactions; Electrocardiography; Humans; Male; Mexiletine; Middle Aged; Theophylline	1989
Oral mexiletine-theophylline interaction. International journal of cardiology, 1987, Volume: 17, Issue:2 Topics: Administration, Oral; Aged; Coronary Disease; Drug Interactions; Humans; Lung Diseases, Obstructive; Male; Mexiletine; Theophylline	1987
Inhibition kinetics of theophylline metabolism by mexiletine and its metabolites. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; Depression, Chemical; Hydroxylation; In Vitro Techniques; Isoenzymes; Kinetics; Mexiletine; Microsomes, Liver; Oxidation-Reduction; Rats; Theophylline	1995
Effect of mexiletine on elimination and metabolic conversion of theophylline and its major metabolites in rats. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:2 Topics: Administration, Oral; Aminophylline; Animals; In Vitro Techniques; Injections, Intravenous; Liver; Male; Mexiletine; Rats; Rats, Wistar; Theophylline; Uric Acid; Xanthines	1993
Involvement of CYP1A2 in mexiletine metabolism. British journal of clinical pharmacology, 1998, Volume: 46, Issue:1 Topics: Anti-Arrhythmia Agents; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Drug Interactions; Humans; In Vitro Techniques; Liver; Mexiletine; Microsomes; Theophylline	1998
Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine. Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:1 Topics: Anti-Arrhythmia Agents; Benzoflavones; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Hydroxylation; Kinetics; Mexiletine; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Saccharomyces cerevisiae; Theophylline	2003
Rapid Characterization of Formulated Pharmaceuticals Using Fast MAS Molecular pharmaceutics, 2019, 07-01, Volume: 16, Issue:7 Topics: Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Cellulose; Drug Compounding; Excipients; Feasibility Studies; Hydrogen; Lactose; Mexiletine; Stearic Acids; Tablets; Theophylline; X-Ray Diffraction	2019