theophylline and mercaptopurine

theophylline has been researched along with mercaptopurine in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (28.57)	18.7374
1990's	1 (4.76)	18.2507
2000's	8 (38.10)	29.6817
2010's	6 (28.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Majumdar, S; Sloan, KB	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Kakác, B; Sarsúnová, M; Semonský, M	1
Friedman, PA	1
Blankenship, LC; Craven, SE	1
Lin, RL; Schaffer, MI; Stein, RJ	1
Roberts, WJ; Sloan, KB	2
Kostromina, KN; Parkhomenko, IM; Pavlov, AS; Simakina, EP	1
JEFFREY, JJ; SCHANKER, LS; TOCCO, DJ	1
HENDERSON, JF; MAZEL, P	1

Reviews

1 review(s) available for theophylline and mercaptopurine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

20 other study(ies) available for theophylline and mercaptopurine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs. Bioorganic & medicinal chemistry letters, 2006, Jul-01, Volume: 16, Issue:13 Topics: Administration, Cutaneous; Drug Delivery Systems; Hydrogen-Ion Concentration; Hydrolysis; Imides; Molecular Structure; Phenols; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds	2006
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
[Reaction of purine derivatives with iodine used as a detection reagent. IX]. Ceskoslovenska farmacie, 1972, Volume: 21, Issue:9 Topics: Caffeine; Indicators and Reagents; Iodine; Mercaptopurine; Methods; Purines; Spectrophotometry, Infrared; Theobromine; Theophylline	1972
Studies on the photodynamic reaction of purines and purine analogues with methylene blue. Biochimica et biophysica acta, 1968, Aug-23, Volume: 166, Issue:1 Topics: Anti-Bacterial Agents; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Light; Manometry; Mercaptopurine; Methylene Blue; Nucleosides; Oxygen Consumption; Purines; Spectrophotometry; Theophylline; Uric Acid; Xanthines	1968
Effect of purine derivatives, papaverine hydrochloride, and imidazole on enterotoxin formation by Clostridium perfringens type A. Canadian journal of microbiology, 1982, Volume: 28, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Clostridium perfringens; Enterotoxins; Imidazoles; Mercaptopurine; Papaverine; Spores, Bacterial; Theophylline	1982
A Purinethol (6-mercaptopurine) fatality in a case of prescription negligence: a gas chromatographic determination of 6-mercaptopurine. Journal of forensic sciences, 1982, Volume: 27, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Chromatography, Gas; Drug Prescriptions; Female; Gas Chromatography-Mass Spectrometry; Humans; Malpractice; Mercaptopurine; Middle Aged; Theophylline	1982
Correlation of aqueous and lipid solubilities with flux for prodrugs of 5-fluorouracil, theophylline, and 6-mercaptopurine: A Potts-Guy approach. Journal of pharmaceutical sciences, 1999, Volume: 88, Issue:5 Topics: Fluorouracil; Mercaptopurine; Prodrugs; Solubility; Theophylline	1999
Prediction of transdermal flux of prodrugs of 5-fluorouracil, theophylline, and 6-mercaptopurine with a series/parallel model. Journal of pharmaceutical sciences, 2000, Volume: 89, Issue:11 Topics: Fluorouracil; Mercaptopurine; Models, Chemical; Myristates; Prodrugs; Skin Absorption; Solubility; Theophylline	2000
[Experimental study of radiosensitizing effect of analogs of purines and pyrimidine bases in cultured HeLa cells]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2001, Issue:8 Topics: Allopurinol; Antimetabolites; Antimetabolites, Antineoplastic; Cell Survival; Cobalt Radioisotopes; Fluorouracil; Gamma Rays; HeLa Cells; Humans; Lethal Dose 50; Mercaptopurine; Phosphodiesterase Inhibitors; Radiation-Sensitizing Agents; Radiotherapy; Radiotherapy Dosage; Tegafur; Theophylline	2001
INTERACTION OF PURINES WITH THE PYRIMIDINE TRANSPORT PROCESS OF THE SMALL INTESTINE. Biochemical pharmacology, 1963, Volume: 12 Topics: Adenine; Caffeine; Carbon Isotopes; Guanine; Intestine, Small; Intestines; Mercaptopurine; Pharmacology; Physiology; Purines; Pyrimidines; Rats; Research; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines	1963
DEMETHYLATION OF PURINE ANALOGS BY MICROSOMAL ENZYMES FROM MOUSE LIVER. Biochemical pharmacology, 1964, Volume: 13 Topics: Animals; Antimetabolites; Caffeine; Carcinoma; Carcinoma, Ehrlich Tumor; Liver; Mercaptopurine; Metabolism; Mice; Purines; Pyrimidines; Research; Sulfhydryl Compounds; Theobromine; Theophylline	1964