theophylline has been researched along with indomethacin in 230 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 129 (56.09) | 18.7374 |
| 1990's | 51 (22.17) | 18.2507 |
| 2000's | 29 (12.61) | 29.6817 |
| 2010's | 21 (9.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banner, BL; Chiu, AM; Cohen, N; Focella, A; Lopresti, RJ; O'Donnell, M; Schaer, B; Todaro, L; Weber, G; Zenchoff, GB | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M | 1 |
| Caron, G; Ermondi, G | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Bengtsson, E | 1 |
| Dusci, LJ; Hackett, LP | 1 |
| Grotjan, HE; Heindel, JJ; Steinberger, E | 1 |
| Denborough, MA; Hau, H; Mitchell, HW | 1 |
| Dembinska-Kiec, A; Rücker, W; Schönhöfer, PS | 1 |
| Breuiller, M; Cedard, L; Ferre, F | 1 |
| Burke, G; Friedman, Y; Lang, M | 1 |
| Rillema, JA | 1 |
| Goff, AK; Major, PW | 1 |
| Granström, E; Malmsten, C; Samuelsson, B | 1 |
| Anderson, LD; Rillema, JA | 1 |
| Birnbaum, JE; Sapp, TM; Tolman, EL | 1 |
| Beatty, CH; Bocek, RM; Novy, MJ; Young, MK | 1 |
| Hall, WJ; O'Donoghue, JP; O'Regan, MG; Penny, WJ | 1 |
| Franks, DJ; Hamet, P; Horrobin, DF; Manku, MS | 1 |
| Anggård, E; Fredholm, BB; Oliw, E | 1 |
| Breuiller, M; Cedard, L; de Pariente, D; Ferre, F | 1 |
| Clanachan, AS; Johns, A; Paton, DM | 1 |
| Chaudhury, TK; Jacobson, ED | 1 |
| Atkins, D; Hammonds, JC; Hillier, K; Hunt, NH; Ibbotson, KJ; Martin, TJ | 1 |
| Cassin, S; Gerencser, GA; Tyler, T | 1 |
| Claesson, HE; Hammarström, S; Lindgren, JA | 1 |
| Puurunen, J | 1 |
| Andersson, KE; Sjögren, C | 1 |
| Everett, RB; Gant, NF; MacDonald, PC; Worley, RJ | 2 |
| Chirigos, MA; Pavlidis, NA; Schultz, RM; Stoychkov, JN | 1 |
| Nakanishi, H; Ohtaki, Y; Ueda, J | 1 |
| Butler, MC; Giannina, T; O'Byrne, EM; Sawyer, WK; Steinetz, BG | 1 |
| Ainz, LF; Carou, M; Gáldiz, B; Gandarias, JM; Gil-Rodrigo, CE; Gómez, R; Vallejo, A | 1 |
| Evans, ML; Graham, MM; Peterson, LM; Thomas, KL | 1 |
| Adner, N; Nygren, A | 1 |
| Lerner, UH; Mellström, D | 1 |
| Sinaiko, AR; Thompson, TR; Wahlig, TM | 1 |
| Clancy, JP; Li, M; McCann, JD; Welsh, MJ | 1 |
| Cornish, J; Gray, DH; Lowe, C; Reid, IR; Skinner, SJ | 1 |
| Nada, M; Nakagami, H | 1 |
| Capron, A; Delneste, Y; Dessaint, JP; Gosset, P; Lassalle, P; Tonnel, AB; Wallaert, B | 1 |
| Harmeyer, J; Kaune, R; Schröder, B | 1 |
| Cortijo, J; Morcillo, EJ; Ortiz, JL; Sanz, CM | 1 |
| Caswell, AM; Leong, WS; Russell, RG | 1 |
| Seechurn, P; Thody, AJ | 1 |
| Dahlen, DD; Evans, ML; Graham, MM; Mahler, PA; Rasey, JS | 1 |
| Kurachi, Y; Mashima, S; Sugimoto, T; Takikawa, R | 1 |
| Argenzio, RA; Clarke, LL | 1 |
| Hope, W; Rose'Meyer, RB | 1 |
| McEwan, GT; Nielsen, CG; Schousboe, B; Skadhauge, E | 1 |
| Cuthbert, AW; Hickman, ME | 1 |
| Brandwein, SR | 1 |
| Fredholm, BB; Lerner, U; Ransjö, M | 1 |
| Fox, CC; Kagey-Sobotka, A; Lichtenstein, LM; Wolf, EJ | 1 |
| Dasarathy, Y; Fanburg, BL | 1 |
| Fredholm, BB; Lerner, UH; Ransjö, M | 1 |
| Hirao, T; Kohno, H; Konno-Amano, S; Mori, H; Sato, Y | 1 |
| Schneider, W; Wehmeier, A | 1 |
| Cannon, ME; Hsu, CH; Twu, BM; Yang, CS | 1 |
| Majewski, H; Murphy, TV | 1 |
| Gustafsson, LE | 1 |
| Cheng, JT; Shinozuka, K | 1 |
| Buxton, DB; Fisher, RA; Olson, MS; Robertson, SM | 1 |
| Fernandes, LB; Goldie, RG; Knight, DA; Paterson, JW; Rigby, PJ; Spina, D | 1 |
| Hoffman, RA; Jordan, ML; Simmons, RL | 1 |
| Goldie, RG; Paterson, JW; Spina, D | 1 |
| Amobi, NI; Smith, IC | 1 |
| Salonen, RO | 1 |
| Bache, RJ; Chen, DG; Dai, XZ; Schwartz, JS | 1 |
| Bache, RJ; Dai, XZ; Laxson, DD; Schwartz, JS | 1 |
| Bauman, JE; Joist, JH; Lagunoff, D; Martin, TW | 1 |
| Kato, R; Nakadate, T; Uzumaki, H; Yamamoto, S | 1 |
| Blomqvist, P; Lindvall, O; Stenevi, U; Wieloch, T | 1 |
| Colmerauer, ME; Davis, CE; Fierer, AS; Goddard, DR; Reed, SL | 1 |
| Bjerregaard, HF; Nielsen, R | 1 |
| Fujimoto, M; Okabayashi, T | 1 |
| Mochan, E; Newton, R; Uhl, J | 1 |
| Wennmalm, M | 1 |
| Jaatinen, T; Karppanen, H; Puurunen, J | 1 |
| Gerber, JG; Nies, AS | 1 |
| Ceroni, G; Dorigo, P; Gaion, RM; Giacometti, A; Maragno, I; Valentini, E | 1 |
| Seyberth, HW | 1 |
| Fredholm, BB; Seideman, P; Sollevi, A | 1 |
| Aliño, SF; Hilario, E | 1 |
| Knee, CD; Krell, RD; Kusner, EJ | 1 |
| Whiting, SJ; Whitney, HL | 1 |
| Bille-Hansen, V; Olsen, UB | 1 |
| Catravas, JD; Ehrhart, IC; Hofman, WF | 1 |
| Miyamoto, T; Nishida, Y; Suzuki, S | 1 |
| Jusko, WJ; Shum, L | 1 |
| Kusenbach, G; Reinhardt, D | 1 |
| Baum, T; Pula, K; Rivelli, M; Sybertz, EJ; Watkins, RW | 1 |
| Carbonaro, C; Gerritsen, ME; Levine, N; Tarlin, N | 1 |
| Austen, KF; Schick, B | 1 |
| Kimura, T; Satoh, S | 1 |
| Berger, E; Gerok, W; Haag, K; Knauf, H; Lübcke, R | 1 |
| Frith, DA; Snart, RS | 1 |
| Cuatrecasas, P; Illiano, G | 1 |
| Flores, AG; Sharp, GW | 1 |
| Cash, WD; Czernik, AJ; Fain, JN; Frost, S; Psychoyos, S | 1 |
| Manganiello, VC; Stoner, J; Vaughan, M | 1 |
| Field, M; Gershon, E; Henderson, A; Kimberg, DV | 1 |
| Francis, DH; Roitt, IM; Sheldon, D; Taylor, WA | 1 |
| Ciosek, CP; Newcombe, DS; Thanassi, NM | 1 |
| Dalton, C; Hope, WC | 1 |
| Hertelendy, F | 1 |
| Bottecchia, D; de Gaetano, G; Vermylen, J | 1 |
| Duhault, J; Laubie, M; LeDouarec, JC | 1 |
| Hall, WJ; O'Regan, MG | 1 |
| Gulati, SM; Talwar, JR | 1 |
| Permin, H; Svenson, M; Wiik, A | 1 |
| Field, M; Langridge-Smith, JE; Rao, MC | 1 |
| Gagnon, G; Regoli, D; Rioux, F | 1 |
| Ishikawa, Y; Takahashi, T; Yamamura, T | 1 |
| Kako, T; Tanaka, M | 1 |
| Kandasamy, SB | 1 |
| Blumberg, JB; Field, M; Smith, PL; Stoff, JS | 1 |
| Okabe, E | 1 |
| Hart, DA | 1 |
| David, JD; Higginbotham, CA | 1 |
| Barr, HA; Nicholas, TE | 1 |
| Brink, C | 1 |
| Avivi, A; Lindner, HR; Shemesh, M | 1 |
| Cox, TC; Els, WJ; Helman, SI; Van Driessche, W | 1 |
| Aiken, JW; Hemker, DP | 1 |
| Faison, EP; Taylor, DA; Wiese, S; Yarbrough, GG | 1 |
| Andersson, KE; Husted, S; Sjögren, C | 1 |
| Greimel, H; Michailov, MC; Prechter, I; Welscher, UE | 1 |
| Donnelly, RP; Rogers, TJ | 1 |
| Cox, TC; Helman, SI; Van Driessche, W | 1 |
| Frizzell, RA; Smith, PL; Stoff, JS; Welsh, MJ | 1 |
| Kandasamy, SB; Williams, BA | 3 |
| Kennedy, TG | 1 |
| Ibsen, KH; Ngo, JL; Orlando, RA | 1 |
| Hackenthal, R; Rascher, W; Seyberth, HW; Wille, L | 1 |
| Badier, M; Fornaris, M; Guillot, C; Orehek, J | 1 |
| Goldenberg, MM; Meurer, RD | 1 |
| Cook, DA; Krueger, CA | 1 |
| Armstrong, EL; Baer, PG; Cagen, LM | 1 |
| Baer, HP; Clanachan, AS; Naughton, P; Scott, GW | 1 |
| Els, WJ; Helman, SI | 1 |
| Sonnenfeld, T; Wennmalm, A | 1 |
| Zenk, KE | 1 |
| Khan, MT; Malik, KU | 1 |
| Aizawa, Y; Kogo, H; Takeuchi, K | 1 |
| Atkins, D; Greaves, M; Ibbotson, KJ; Martin, TJ | 1 |
| Burnstock, G; Vials, AJ | 1 |
| Fessler, HE; Pearse, DB; Wagner, EM | 1 |
| Emery, DL; McClure, SJ | 1 |
| Chłopicki, S; Gryglewski, RJ | 1 |
| Hargittai, PT; Lieberman, EA; Mustafa, SJ; Olanrewaju, HA | 1 |
| Jarvis, JE; Reeves, JJ; Sheehan, MJ; Strong, P | 1 |
| Mellemkjaer, S; Nielsen-Kudsk, JE | 1 |
| Limberger, N; Rump, LC; Trendelenburg, AU | 1 |
| Martin, PL; Potts, AA | 1 |
| Matsuki, N; Nagata, K; Saito, H | 1 |
| Langer, JC; Mumford, DA; Sohal, SS | 1 |
| Häglund, BO; Sundelöf, LO; Upadrashta, SM | 1 |
| Burnstock, G; Vials, A | 1 |
| Belt, JJ; Fedan, JS; Frazer, DG; Yuan, LX | 1 |
| Ainz, LF; Bergaretxe, I; Carou, M; Galdiz, B; Gandarias, JM; Gil-Rodrigo, CE; Gomez, R; Vallejo, A | 1 |
| Anton, M; Cortijo, J; Morcillo, EJ; Sanz, CM; Villagrasa, V | 1 |
| Cheung, LY; Darnell, MP; Wood, JG | 1 |
| Bogle, RG; Davies, G; MacAllister, RJ; Vallance, P | 1 |
| Higasa, S; Kakishita, E; Suehiro, A; Tsujioka, H; Ueda, M; Yoshimoto, H | 1 |
| Kato, S; Okabe, S; Takeuchi, K | 1 |
| Hollingsworth, M; Piper, AS | 2 |
| Alexandrov, VA; Bespalov, VG; Petrov, AS; Troyan, DN | 1 |
| Chlopicki, S; Gryglewski, RJ; Jakubowski, A; Lomnicka, M; Niezabitowski, P | 1 |
| Broadley, KJ; Maddock, HL | 1 |
| Bari, F; Busija, DW; Louis, TM | 1 |
| Franková, D; Holý, A; Zídek, Z | 1 |
| Dumont, L; Fontaine, E; Jasmin, G; Véronneau, M; Viau, S | 1 |
| Akbaş, N; Barlas, A; Küçükhüseyin, C; Oncel, H; Payat, M; Silan, C | 1 |
| Nilsson, GE; Sundin, L | 1 |
| Barahona, MV; Bustamante, S; García-Sacristán, A; Hernández, M; Orensanz, LM | 1 |
| Krishnan, TR; Liu, P | 1 |
| Dick, AJ; Douglas, JA; Melanson, RL; Redden, PR | 1 |
| Boussery, K; Delaey, C; Van de Voorde, J | 1 |
| Ralevic, V | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecien, S; Pajdo, R; Pawlik, M; Ptak, A; Sliwowski, Z | 1 |
| Koenig, HM; Pelligrino, DA; Santizo, RA; Xu, HL | 1 |
| AL-Shabanah, O; EL-Kashef, H; Khattab, M | 1 |
| Abbas, MR; Coney, AM; Marshall, JM; Ray, CJ | 1 |
| Picker, KM; Schmidt, AG; Wartewig, S | 1 |
| Debnath, S; Predecki, P; Suryanarayanan, R | 1 |
| Sadan, G; Tuncel, B; Usta, C | 1 |
| Finocchiaro, S; Levine, RA; Nandi, J; Ong, G; Saud, B | 1 |
| Afrasiabi Garekani, H; Akhgari, A; Farahmand, F; Sadeghi, F; Vandamme, TF | 1 |
| Battastini, AM; Bavaresco, L; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G; Wink, MR | 1 |
| Hrabálek, A; Janůsová, B; Kovaríková, P; Novotný, J; Novotný, M; Vávrová, K | 1 |
| Araújo, JR; Gonçalves, P; Martel, F; Pinho, MJ | 1 |
| Hrabálek, A; Janůsová, B; Novotný, J; Novotný, M; Vávrová, K | 1 |
| Bune, LT; González-Alonso, J; Hellsten, Y; Mortensen, SP; Pilegaard, H; Saltin, B | 1 |
| Hellsten, Y; Mortensen, SP; Nyberg, M; Saltin, B; Thaning, P | 1 |
| Antonios, D; Gautier, JC; Lacour, S; Pallardy, M | 1 |
| Hrabálek, A; Janůšová, B; Lorenc, P; Palát, K; Vávrová, K; Vavrysová, H; Zbytovská, J | 1 |
| Forbes, RT; Gray, J; Hulse, WL | 1 |
| Hirakura, Y; Terada, K; Teramura, T; Yamashita, H; Yuda, M | 1 |
| Bair, E; Colby, E | 1 |
| Coboeken, K; Ince, I; Meyer, M; Schmidt, S; Schnizler, K; Somani, AA; Thelen, K; Trame, MN; Willmann, S; Zheng, S | 1 |
| Aleksza, M; Dobolyi, Á; Juhász, G; Kékesi, KA; Kovács, Z; Lakatos, RK; Todorov, MI | 1 |
| Kováčik, A; Pullmannová, P; Sochorová, M; Staňková, K; Vávrová, K; Zbytovská, J | 1 |
| Čuříková, BA; Diblíková, P; Filková, B; Kováčik, A; Procházková, K; Svoboda, J; Vávrová, K; Zbytovská, J | 1 |
5 review(s) available for theophylline and indomethacin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug use in the newborn. Effects on the kidney.
Topics: Antihypertensive Agents; Diuretics; Dopamine; Drug Therapy; Humans; Indomethacin; Infant, Newborn; Kidney; Theophylline | 1992 |
Effects of atrial natriuretic peptide on coronary vascular resistance in the intact awake dog.
Topics: Animals; Atrial Natriuretic Factor; Coronary Circulation; Coronary Vessels; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Indomethacin; Injections, Intra-Arterial; Receptors, Purinergic; Theophylline; Vascular Resistance; Vasodilation; Wakefulness | 1988 |
Control of vascular responsiveness during human pregnancy.
Topics: 20-alpha-Dihydroprogesterone; Angiotensin II; Aspirin; Blood Vessels; Cyclic AMP; Female; Humans; Hypertension; Indomethacin; Muscle, Smooth, Vascular; Pregnancy; Pregnancy Complications, Cardiovascular; Progesterone; Prostaglandins; Theophylline | 1980 |
An overview of perinatal clinical pharmacology.
Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digoxin; Female; Fetus; Furosemide; Gentamicins; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Penicillins; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Tetracycline; Theophylline | 1981 |
1 trial(s) available for theophylline and indomethacin
| Article | Year |
|---|---|
Effect of prolonged indomethacin therapy on renal function and selected vasoactive hormones in very-low-birth-weight infants with symptomatic patent ductus arteriosus.
Topics: Arginine Vasopressin; Clinical Trials as Topic; Creatinine; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Low Birth Weight; Infant, Newborn; Kidney; Prostaglandins; Renin; Theophylline | 1983 |
224 other study(ies) available for theophylline and indomethacin
| Article | Year |
|---|---|
3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.
Topics: Animals; Benzopyrans; Chemical Phenomena; Chemistry; Chromans; Guinea Pigs; Leukotriene Antagonists; Male; Models, Molecular; Rats; Receptors, Immunologic; Receptors, Leukotriene; Stereoisomerism; Structure-Activity Relationship | 1989 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid | 2002 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Studies on the mechanism of the breakdown of the blood-aqueous barrier in the rabbit eye.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Blood; Ciliary Body; Drug Interactions; Eye; Imidazoles; Indomethacin; Intraocular Pressure; Iris; Melanocyte-Stimulating Hormones; Polyphloretin Phosphate; Prostaglandins; Prostaglandins E; Rabbits; Theophylline; Uveitis | 1977 |
High performance liquid chromatography in clinical toxicology. I. General drugs.
Topics: Acetaminophen; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Indomethacin; Pharmaceutical Preparations; Theophylline; Thiazines; Toxicology | 1978 |
Prostaglandin inhibition of testosterone production induced by luteinizing hormone, dibutyryl cyclic AMP or 3-isobutyl-1-methyl xanthine in dispersed rat testicular interstitial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; In Vitro Techniques; Indomethacin; Luteinizing Hormone; Male; Prostaglandins; Radioimmunoassay; Rats; Testis; Testosterone; Theophylline | 1978 |
In vitro action of combined salbutamol and theophylline on anaphylactic contractions, mediator release and cyclic 3',5'-adenosine monophosphate in lung parenchyma.
Topics: Albuterol; Anaphylaxis; Animals; Cyclic AMP; Guinea Pigs; Histamine Release; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Muscle, Smooth; Prostaglandins F; Proteins; Theophylline | 1979 |
PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Coronary Vessels; Cyclic AMP; Dipyridamole; Epoprostenol; In Vitro Techniques; Indomethacin; Prostaglandins; Stimulation, Chemical; Theophylline; Time Factors | 1979 |
Human placental cAMP phosphodiesterase activity kinetic properties and sensitivity to some drugs and hormones.
Topics: Caffeine; Cyclic AMP; Epinephrine; Estradiol; Female; Flufenamic Acid; Hormones; Humans; Imidazoles; Indomethacin; Insulin; Kinetics; Magnesium; Norepinephrine; Pharmacology; Phosphoric Diester Hydrolases; Placenta; Pregnancy; Progesterone; Prostaglandins; Theophylline | 1975 |
Further characterization of bovine thyroid prostaglandin synthase.
Topics: 5,8,11,14-Eicosatetraynoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Bucladesine; Cattle; Cyclic AMP; Edetic Acid; Fatty Acids, Unsaturated; In Vitro Techniques; Indomethacin; Kinetics; Mixed Function Oxygenases; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Subcellular Fractions; Theophylline; Thyroid Gland; Thyrotropin | 1975 |
Effects of arachidonic acid on RNA metabolism in mammary gland explants of mice.
Topics: Animals; Arachidonic Acids; Breast; Bucladesine; Cyclic GMP; Female; Indomethacin; Linoleic Acids; Mice; Oleic Acids; Pregnancy; Prolactin; Prostaglandins E; Prostaglandins F; Quinine; RNA; Stearic Acids; Theophylline; Uridine | 1975 |
Bovine luteal cyclic AMP and cyclic GMP phosphodiesterase activity; sensitivity to various drugs and hormones.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Corpus Luteum; Cyclic AMP; Female; Hormones; Imidazoles; Indomethacin; Kinetics; Papaverine; Phosphoric Diester Hydrolases; Prostaglandins; Theophylline | 1976 |
Cyclic AMP inhibits synthesis of prostaglandin endoperoxide (PGG2) in human platelets.
Topics: Arachidonic Acids; Blood Platelets; Bucladesine; Collagen; Cyclic AMP; Cyclic GMP; Humans; Indomethacin; Peroxides; Platelet Aggregation; Prostaglandins; Prostaglandins E; Serotonin; Theophylline | 1976 |
Phospholipases and the effect of prolactin on uridine incorporation into RNA in mammary gland explants of mice.
Topics: Animals; Arachidonic Acids; Bucladesine; Cyclic GMP; Female; Indomethacin; Mammary Glands, Animal; Organ Culture Techniques; Phospholipases; Pregnancy; Prolactin; Prostaglandins E; Quinine; Rats; RNA; Theophylline; Transcription, Genetic; Uridine | 1976 |
Cyclic AMP-phosphodiesterase and epidermal mitosis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Biphenyl Compounds; Bufexamac; Etazolate; Glycyrrhiza; Hydroxamic Acids; Indomethacin; Male; Mice; Mice, Inbred C3H; Mitosis; Papaverine; Phosphodiesterase Inhibitors; Plant Extracts; Plants, Medicinal; Skin; Theophylline | 1976 |
Effect of Indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Drug Synergism; Epinephrine; Female; Haplorhini; Indomethacin; Macaca mulatta; Myometrium; Phosphoric Diester Hydrolases; Pregnancy; Prostaglandins E; Theophylline; Uterine Contraction; Uterus | 1976 |
Endogenous prostaglandins, adenosine 3':5'-monophosphate and sodium transport across isolated frog skin.
Topics: Acetaminophen; Animals; Arachidonic Acids; Biological Transport; Cyclic AMP; Female; In Vitro Techniques; Indomethacin; Male; Prostaglandins E; Rana temporaria; Skin; Sodium; Theophylline | 1976 |
Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation.
Topics: Angiotensin II; Animals; Caffeine; Drug Synergism; Female; Guinea Pigs; Ileum; Indomethacin; Male; Mesenteric Arteries; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Prostaglandin Antagonists; Prostaglandins E; Rats; Theophylline; Uterus; Xanthines | 1977 |
Effect of indomethacin on the renal actions of theophylline.
Topics: Animals; Blood Pressure; Creatinine; Cyclic AMP; Diuresis; Drug Interactions; Indomethacin; Kidney; Male; Potassium; Prostaglandins; Rabbits; Renin; Sodium; Theophylline; Time Factors | 1977 |
[3'5'-Cyclic AMP phosphodiesterase activity in the internal and external layers of human myometrium at the end of pregnancy].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Female; Humans; Imidazoles; Indomethacin; Kinetics; Myometrium; Papaverine; Placenta; Pregnancy; Pregnancy Trimester, Third; Theophylline; Uterus | 1977 |
Presynaptic inhibitory actions of adenine nucleotides and adenosine on neurotransmission in the rat vas deferens.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Animals; Atropine; Depression, Chemical; Dipyridamole; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Rats; Synapses; Synaptic Transmission; Theophylline; Vas Deferens | 1977 |
Prostaglandin cytoprotection of gastric mucosa.
Topics: Action Potentials; Animals; Bucladesine; Cyclic AMP; Dogs; Electrophysiology; Female; Gastric Mucosa; Indomethacin; Male; Prostaglandins E; Sodium; Theophylline | 1978 |
Secretion of prostaglandins as bone-resorbing agents by renal cortical carcinoma in culture.
Topics: Animals; Bone Resorption; Cyclic AMP; Humans; In Vitro Techniques; Indomethacin; Kidney Cortex; Kidney Neoplasms; Mice; Parathyroid Hormone; Prostaglandins; Prostaglandins E; Theophylline | 1977 |
Sodium transport by isolated bullfrog small intestine. Effect of prostaglandin E1.
Topics: Animals; Anura; Biological Transport, Active; Cyclic AMP; Indomethacin; Intestinal Mucosa; Intestine, Small; Membrane Potentials; Prostaglandins E; Rana catesbeiana; Sodium; Theophylline | 1978 |
Stimulation of arachidonic acid release and prostaglandin production in 3T3 fibroblasts by adenosine 3':5'-monophosphate.
Topics: Arachidonic Acids; Bucladesine; Cell Line; Cyclic AMP; Fatty Acids; Hydrocortisone; Indomethacin; Prostaglandins; Stearates; Theophylline | 1978 |
Studies on the mechanism of the inhibitory effect of ethanol on the gastric acid output in the rat.
Topics: Animals; Anti-Inflammatory Agents; Bucladesine; Carbachol; Depression, Chemical; Ethanol; Gastric Juice; Histamine; Indomethacin; Male; Osmolar Concentration; Papaverine; Pentagastrin; Phenylbutazone; Rats; Theophylline | 1978 |
Inhibition of ATP-induced contraction in the guinea-pig urinary bladder in vitro and in vivo.
Topics: Adenosine; Adenosine Triphosphate; Amines; Animals; Female; Guinea Pigs; Indomethacin; Isoproterenol; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Parasympatholytics; Propranolol; Tetrodotoxin; Theophylline; Urinary Bladder | 1979 |
Vascular responsiveness to pressor agents during human pregnancy.
Topics: Aldosterone; Angiotensin II; Aspirin; Female; Hematocrit; Humans; Hypertension; Indomethacin; Pregnancy; Pregnancy Complications, Hematologic; Renin; Sickle Cell Trait; Theophylline; Vasomotor System | 1979 |
Factors affecting macrophage cytotoxic activity with particular emphasis on corticosteroids and acute stress.
Topics: Adrenal Cortex Hormones; Animals; Cytochalasin B; Cytotoxicity, Immunologic; Drug Evaluation, Preclinical; Glucocorticoids; Histamine; Indomethacin; Insulin; Interferons; Isoproterenol; Macrophages; Male; Mice; Prostaglandins E; Restraint, Physical; Stress, Physiological; Theophylline | 1979 |
[Effects of adenosine compounds of the vascular bed and effects of dilazep, theophylline, and indomethacin on blood flow changes of the postocclusive renal vessels].
Topics: Adenine Nucleotides; Adenosine; Angiotensin II; Animals; Azepines; Blood Flow Velocity; Blood Vessels; Dilazep; Dogs; Drug Synergism; Female; Femoral Artery; Indomethacin; Kidney; Ligation; Male; Mesenteric Arteries; Norepinephrine; Renal Artery; Theophylline | 1977 |
Post-implantation termination of pregnancy in rats.
Topics: Abortifacient Agents; Alkaline Phosphatase; Aminoglutethimide; Animals; Cyclofenil; Diethylstilbestrol; Drug Synergism; Embryonic Development; Estradiol; Estradiol Congeners; Estrogen Antagonists; Female; Indomethacin; Organ Size; Pregnancy; Pregnancy, Animal; Progesterone; Prolactin; Prostaglandins; Pyrrolidines; Rats; Theophylline; Uterus | 1976 |
[Specific inhibition by ATP of histamine-stimulated acid secretion in the gastric glands of the rabbit].
Topics: Adenosine Triphosphate; Animals; Bucladesine; Carbachol; Depression, Chemical; Female; Gastric Acid; Gastric Mucosa; Histamine; Histamine Antagonists; Indomethacin; Male; Prostaglandins; Pyrrolidinones; Rabbits; Rolipram; Secretory Rate; Theophylline | 1992 |
Vascular response to fractionated irradiation in the rat lung.
Topics: Animals; Capillary Permeability; Cyproheptadine; Dexamethasone; Indomethacin; Lung; Male; Pulmonary Circulation; Rats; Rats, Inbred Strains; Specific Pathogen-Free Organisms; Theophylline | 1992 |
The influence of indomethacin, theophylline, and propranolol on ethanol augmentation of glucose-induced insulin secretion.
Topics: Adult; Ethanol; Female; Glucagon; Glucose; Humans; Indomethacin; Insulin; Insulin Secretion; Male; Propranolol; Theophylline; Time Factors | 1992 |
Caffeine has the capacity to stimulate calcium release in organ culture of neonatal mouse calvaria.
Topics: Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Caffeine; Calcium; Dose-Response Relationship, Drug; Flurbiprofen; Indomethacin; Mice; Organ Culture Techniques; Parathyroid Hormone; Theophylline | 1992 |
Calcium-dependent regulation of airway epithelial chloride channels.
Topics: Animals; Bumetanide; Calcimycin; Calcium; Cells, Cultured; Chloride Channels; Chlorides; Cyclic AMP; Dogs; Epithelium; Indomethacin; Iodides; Ion Channels; Isoproterenol; Kinetics; Membrane Proteins; Muscle, Smooth; Nitrobenzoates; Potassium; Theophylline; Trachea; Valinomycin | 1990 |
Adenylate cyclase blockers dissociate PTH-stimulated bone resorption from cAMP production.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Animals; Bone and Bones; Bone Resorption; Calcium; Cyclic AMP; Dideoxyadenosine; DNA Replication; In Vitro Techniques; Indomethacin; Isomerism; Kinetics; Mice; Parathyroid Hormone; Phenylalanine; Protein Biosynthesis; Theophylline | 1990 |
In vitro evaluation of micronized low-substituted hydroxypropylcellulose as an insoluble swellable matrix for sustained-release tablets.
Topics: Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Evaluation Studies as Topic; Indomethacin; Particle Size; Powders; Procainamide; Theophylline; X-Ray Diffraction | 1991 |
Neutrophil-endothelial cell interaction: evidence in vitro for a regulation by endothelial cells of neutrophil functions.
Topics: Calcimycin; Cell Communication; Chemotaxis, Leukocyte; Endothelium, Vascular; Fetal Blood; Humans; In Vitro Techniques; Indomethacin; Luminescent Measurements; Masoprocol; Models, Biological; Neutrophils; Theophylline; Umbilical Veins | 1991 |
Effects of calcitriol on stimulation of ion transport in pig jejunal mucosa.
Topics: Animals; Calbindins; Calcimycin; Calcitriol; Calcium; Calcium Channel Blockers; Chlorides; Gallic Acid; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ion Transport; Jejunum; Rickets; S100 Calcium Binding Protein G; Sodium; Swine; Theophylline; Verapamil | 1991 |
Effects of dantrolene on the responses to methylxanthines in the isolated guinea-pig trachea.
Topics: Acetylcholine; Albuterol; Animals; Caffeine; Calcium; Dantrolene; Female; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Theophylline; Trachea | 1991 |
Evidence for the presence of P2-purinoceptors at the surface of human articular chondrocytes in monolayer culture.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Cartilage, Articular; Cells, Cultured; Humans; Indomethacin; Nucleotides; Pertussis Toxin; Prostaglandins E; Receptors, Purinergic; Theophylline; Virulence Factors, Bordetella | 1991 |
The effect of ultraviolet radiation and melanocyte-stimulating hormone on tyrosinase activity in epidermal melanocytes of the mouse.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Cells; Female; Indomethacin; Male; Melanocyte-Stimulating Hormones; Melanocytes; Mice; Monophenol Monooxygenase; Protein Kinase C; Tetradecanoylphorbol Acetate; Theophylline; Ultraviolet Rays | 1990 |
Pharmacological alteration of the lung vascular response to radiation.
Topics: Animals; Capillary Permeability; Cholecalciferol; Cromolyn Sodium; Cyproheptadine; Depression, Chemical; Dexamethasone; Diethylcarbamazine; Endothelium, Vascular; Indomethacin; Lung; Male; Rats; Rats, Inbred Strains; Theophylline | 1990 |
Adenosine-5'-triphosphate-induced sinus tachycardia mediated by prostaglandin synthesis via phospholipase C in the rabbit heart.
Topics: Adenosine Triphosphate; Animals; Apamin; Aspirin; Female; Heart; Indomethacin; Male; Myocardium; Neomycin; Perfusion; Pertussis Toxin; Prostaglandins; Rabbits; Receptors, Purinergic; Tachycardia, Sinus; Theophylline; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
NaCl transport across equine proximal colon and the effect of endogenous prostanoids.
Topics: Aldosterone; Amiloride; Animals; Colon; Dinoprostone; Electric Conductivity; Horses; In Vitro Techniques; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Kinetics; Models, Biological; Muscle, Smooth; Prostaglandins; Sodium Chloride; Theophylline | 1990 |
Evidence that A2 purinoceptors are involved in endothelium-dependent relaxation of the rat thoracic aorta.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta, Thoracic; Endothelium, Vascular; Hemoglobins; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Norepinephrine; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline | 1990 |
Effect of age on the secretory capacity of pig small intestine in vivo and in vitro.
Topics: Aging; Animals; Chlorides; Cholera Toxin; Dinoprostone; Electric Conductivity; Electrophysiology; Ileum; In Vitro Techniques; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Jejunum; Muscle Development; Muscle, Smooth; Sodium; Swine; Theophylline | 1990 |
Indirect effects of adenosine triphosphate on chloride secretion in mammalian colon.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Chlorides; Colon; Epithelium; In Vitro Techniques; Indomethacin; Kinetics; Male; Rats; Rats, Inbred Strains; Tetrodotoxin; Theophylline | 1985 |
Regulation of interleukin 1 production by mouse peritoneal macrophages. Effects of arachidonic acid metabolites, cyclic nucleotides, and interferons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acids; Bucladesine; Cells, Cultured; Dinoprostone; Indomethacin; Interferon-gamma; Interleukin-1; Isoproterenol; Kinetics; Macrophages; Melitten; Mice; Mice, Inbred C3H; Prostaglandins E; Theophylline | 1986 |
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone and Bones; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Indomethacin; Kinetics; Lysosomes; Mice; Parathyroid Hormone; Prostaglandins E; Pyrrolidinones; Rolipram; Theophylline | 1986 |
Comparison of human lung and intestinal mast cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Ascitic Fluid; Cells, Cultured; Cromolyn Sodium; Histamine Release; Humans; Immunoglobulin E; Indomethacin; Intestinal Mucosa; Lung; Mast Cells; Quercetin; Rats; Theophylline; Thioxanthenes; Xanthones | 1988 |
Elevation of angiotensin converting enzyme by 3-isobutyl-1-methylxanthine in cultured endothelial cells: a possible role for calmodulin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calmodulin; Cattle; Cells, Cultured; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Imidazoles; Indomethacin; Peptidyl-Dipeptidase A; Propranolol; Theophylline; Trifluoperazine; Verapamil; Xanthines | 1988 |
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bone Resorption; Calcium; Cells, Cultured; Cholera Toxin; Cyclic AMP; Hydrocortisone; Indomethacin; Meclofenamic Acid; Mice; Mice, Inbred Strains; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Skull; Theophylline | 1988 |
Passive air-pouch anaphylaxis in rats. II. Pharmacological characterization.
Topics: Adult; Air; Anaphylaxis; Animals; Capillary Permeability; Chromones; Cromolyn Sodium; Dexamethasone; Dinoprostone; Exudates and Transudates; Histamine Release; Humans; Immunization, Passive; Indomethacin; Isoproterenol; Ketotifen; Masoprocol; Models, Biological; ortho-Aminobenzoates; Pyrilamine; Rats; Rats, Inbred Strains; Theophylline | 1989 |
Platelet volume parameters as a diagnostic tool: the influence of anticoagulation and storage conditions on platelet impedance volume.
Topics: Anticoagulants; Blood Platelets; Blood Preservation; Citrates; Citric Acid; Colforsin; Edetic Acid; Glutaral; Humans; Hydrogen-Ion Concentration; Indomethacin; Platelet Count; Temperature; Theophylline | 1989 |
The effect of theophylline and cyclic adenosine 3',5'-monophosphate on renin release by afferent arterioles.
Topics: Animals; Arterioles; Bucladesine; Calcium; Colforsin; Cyclic AMP; In Vitro Techniques; Indomethacin; Kidney; Male; Meclofenamic Acid; Rabbits; Renin; Theophylline | 1989 |
Modulation of noradrenaline release in slices of rat kidney cortex through alpha 1- and alpha 2-adrenoceptors.
Topics: Animals; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Indomethacin; Kidney Cortex; Male; Methoxamine; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Renal Circulation; Theophylline | 1989 |
Mechanisms involved in the action of prostaglandins as modulators of neurotransmission.
Topics: Acetylcholine; Adenosine; Animals; Blood Pressure; Dilazep; Electric Stimulation; Female; Heart Rate; In Vitro Techniques; Indomethacin; Kidney; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Prostaglandins; Rabbits; Theophylline; Xanthines | 1989 |
Participation of prostaglandin E2 in the purinergic neurotransmission of gut.
Topics: Adenine Nucleotides; Adenosine; Animals; Apamin; Dinoprostone; Dipyridamole; Female; Guinea Pigs; Ileum; Indomethacin; Male; Muscle, Smooth; Prostaglandins E; Receptors, Purinergic; Synaptic Transmission; Synaptosomes; Theophylline | 1987 |
Stimulation of glycogenolysis and vasoconstriction by adenosine and adenosine analogues in the perfused rat liver.
Topics: Adenosine; Animals; Calcium; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; Indomethacin; Liver; Liver Glycogen; Male; Phosphorylase a; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Vasoconstriction | 1987 |
Beta-adrenoceptor desensitization in guinea-pig isolated trachea.
Topics: Animals; Autoradiography; Carbachol; Female; Fenoterol; Guinea Pigs; Hydrocortisone; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Muscle Relaxation; Norepinephrine; Quinacrine; Receptors, Adrenergic, beta; Theophylline; Trachea | 1988 |
Further characterization of the subset-specific effects of prostaglandin E2 on T lymphocyte clone function.
Topics: Animals; Bucladesine; Cell Movement; Clone Cells; Dinoprostone; Indomethacin; Kinetics; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; T-Lymphocytes; Theophylline | 1987 |
Beta agonist-induced desensitization in pig bronchus.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Airway Resistance; Animals; Bronchi; Colforsin; Fenoterol; Hydrocortisone; In Vitro Techniques; Indomethacin; Isoproterenol; Muscle Contraction; Muscle Relaxation; Norepinephrine; Phenylephrine; Quinacrine; Receptors, Adrenergic, beta; Stereoisomerism; Swine; Theophylline | 1986 |
A study of the post-tetanic twitch depression at the prostatic end of the rat vas deferens.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Electric Stimulation; Electrophysiology; Indomethacin; Magnesium; Male; Prostate; Rats; Theophylline; Vas Deferens | 1987 |
Bronchodilator drugs and their combinations antagonize the dose-related leukotriene D4-induced airway obstruction in guinea pigs.
Topics: Airway Obstruction; Animals; Blood Pressure; Bronchodilator Agents; Drug Interactions; Female; Guinea Pigs; Heart Rate; Indomethacin; Ipratropium; Lung Compliance; SRS-A; Terbutaline; Theophylline | 1985 |
Effects of atrial natriuretic peptide in the canine coronary circulation.
Topics: Animals; Atrial Natriuretic Factor; Coronary Circulation; Dogs; Hemodynamics; Indomethacin; Propranolol; Receptors, Purinergic; Theophylline; Vasodilation | 1988 |
Activation of human platelets by N-substituted aminophospholipids.
Topics: 4-Chloro-7-nitrobenzofurazan; Adenosine Diphosphate; Blood Platelets; Cyclic AMP; Epoprostenol; Humans; Indomethacin; Phosphatidylserines; Platelet Aggregation; Serotonin; Theophylline; Thromboxane A2 | 1985 |
Lipoxygenase inhibitors and cyclic AMP-mediated insulin secretion caused by forskolin, theophylline and dibutyryl cyclic AMP.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bucladesine; Catechols; Colforsin; Cyclic AMP; Diterpenes; Indomethacin; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Lipoxygenase Inhibitors; Male; Masoprocol; Pyrazoles; Rats; Secretory Rate; Theophylline | 1985 |
Cyclic AMP concentrations in rat neocortex and hippocampus during and following incomplete ischemia: effects of central noradrenergic neurons, prostaglandins, and adenosine.
Topics: Adenosine; Animals; Brain Ischemia; Cerebral Cortex; Cyclic AMP; Energy Metabolism; Fatty Acids, Nonesterified; Glycolysis; Hippocampus; Indomethacin; Locus Coeruleus; Male; Norepinephrine; Prostaglandins; Rats; Theophylline | 1985 |
Effect of theophylline on differentiation of Trypanosoma brucei.
Topics: Aminophylline; Animals; Cell Differentiation; Cyclic AMP; Female; Indomethacin; Prostaglandins; Rats; Rats, Inbred Strains; Theophylline; Trypanosoma brucei brucei; Trypanosomiasis, African | 1985 |
Trifluoperazine stimulated sodium transport by increased prostaglandin E2 synthesis in isolated frog skin (Rana esculenta).
Topics: Animals; Biological Transport, Active; Calcimycin; Calcium; Cell Membrane Permeability; Cyclic AMP; Dinoprostone; Female; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Prostaglandins E; Rana esculenta; Skin; Sodium; Theophylline; Trifluoperazine; Vasopressins | 1986 |
Bradykinin-induced cyclic AMP accumulation in mouse fibrosarcoma independent of prostaglandin E2 formation.
Topics: Animals; Bradykinin; Cells, Cultured; Cyclic AMP; Dinoprostone; Fibrosarcoma; Indomethacin; Mice; Prostaglandins E; Theophylline; Time Factors | 1986 |
Evidence that interleukin-1 induction of synovial cell plasminogen activator is mediated via prostaglandin E2 and cAMP.
Topics: Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Humans; Indomethacin; Interleukin-1; Microbial Collagenase; Plasminogen Activators; Prostaglandins E; Synovial Membrane; Theophylline | 1986 |
Effect of hypoxia on nerve-stimulation-induced release of noradrenaline from the rabbit heart.
Topics: Adenosine; Animals; Electric Stimulation; Epoprostenol; Female; Heart; Hypoxia; Indomethacin; Male; Myocardium; Norepinephrine; Rabbits; Sympathetic Nervous System; Theophylline | 1988 |
Stimulatory effect of prostaglandin F2 alpha on gastric acid secretion in rats.
Topics: Animals; Dinoprost; Dose-Response Relationship, Drug; Gastric Acid; Indomethacin; Male; Meclofenamic Acid; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Vagotomy | 1988 |
Renal vasoconstrictor response to hypertonic saline in the dog: effects of prostaglandins, indomethacin and theophylline.
Topics: Animals; Blood Pressure; Dinoprostone; Dogs; Epoprostenol; Feedback; Female; Indomethacin; Kidney Glomerulus; Kidney Tubules; Male; Prostaglandins E; Regional Blood Flow; Renal Circulation; Saline Solution, Hypertonic; Sodium; Theophylline; Vasoconstriction | 1986 |
The response of isolated guinea-pig aorta to amrinone.
Topics: Adenosine; Adenosine Deaminase; Amrinone; Animals; Aorta, Thoracic; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Quinidine; Theophylline | 1988 |
[New aspects on the pathogenesis of patent ductus arteriosus in premature infants].
Topics: 6-Ketoprostaglandin F1 alpha; Combined Modality Therapy; Dinoprostone; Ductus Arteriosus, Patent; Epoprostenol; Humans; Indomethacin; Infant, Newborn; Prostaglandins; Prostaglandins E; Pulmonary Circulation; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Theophylline | 1986 |
Additive renal effects of indomethacin and dipyridamole in man.
Topics: Adenosine; Adolescent; Adult; Body Water; Dipyridamole; Diuresis; Drug Interactions; Female; Glomerular Filtration Rate; Humans; Indomethacin; Kidney; Kidney Diseases; Male; Middle Aged; Natriuresis; p-Aminohippuric Acid; Prostaglandins; Theophylline | 1987 |
Effect of indomethacin and acetylsalicylic acid (ASA) on peroxidase activity of gastric mucosa of rat.
Topics: Animals; Aspirin; Female; Gastric Mucosa; Histocytochemistry; Indomethacin; Male; Peroxidases; Rats; Rats, Inbred Strains; Theophylline | 1987 |
Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat.
Topics: Animals; Capillary Permeability; Chromones; Dose-Response Relationship, Drug; Indomethacin; Masoprocol; Methysergide; Nifedipine; Phenoxybenzamine; Phospholipid Ethers; Platelet Activating Factor; Pyrilamine; Rats; Theophylline; Thiazoles | 1987 |
Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat.
Topics: Animals; Body Weight; Caffeine; Calcium; Diet; Dose-Response Relationship, Drug; Indomethacin; Male; Rats; Rats, Inbred Strains; Theophylline; Time Factors | 1987 |
Exaggerated hypotension by N-formylmethionylleucyl-phenylalanine in indomethacin pretreated rats. Role of toxic oxygen.
Topics: Animals; Ascorbic Acid; Blood Pressure; Dimethyl Sulfoxide; Endotoxins; Female; Glucagon; Hypotension; Ibuprofen; Indomethacin; Isoproterenol; N-Formylmethionine Leucyl-Phenylalanine; Oxygen; Rats; Rats, Inbred Strains; Theophylline | 1986 |
Prostanoid inhibition potentiates vasoconstrictor response to acetylcholine in dog lung.
Topics: Acetylcholine; Animals; Aspirin; Blood Pressure; Dogs; Female; Indomethacin; Male; Prostaglandins; Pulmonary Circulation; Receptors, Muscarinic; Theophylline; Vascular Resistance; Vasoconstriction | 1986 |
Suppression by 5'-methylthioadenosine of histamine or leukotriene-induced contraction in isolated guinea pig tracheal rings.
Topics: Adenosine; Animals; Deoxyadenosines; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle Relaxation; Propranolol; Receptors, Purinergic; SRS-A; Tetrodotoxin; Theophylline; Thionucleosides | 1986 |
Reversed-phase high-performance liquid chromatographic determination of verofylline in rat serum.
Topics: Animals; Bronchodilator Agents; Chromatography, High Pressure Liquid; Indomethacin; Kinetics; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Theophylline | 1986 |
[Peculiarities of drug therapy in childhood].
Topics: Apnea; Biological Availability; Biotransformation; Caffeine; Child; Child, Preschool; Dexamethasone; Drug Therapy; Ductus Arteriosus, Patent; Half-Life; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Premature, Diseases; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Receptors, Drug; Theophylline; Tissue Distribution | 1986 |
Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Blood Pressure; Coronary Circulation; Dogs; Extremities; Female; Heart; Heart Rate; Hexamethonium Compounds; Indomethacin; Male; Myocardial Contraction; Platelet Activating Factor; Pyrazoles; Regional Blood Flow; Theophylline; Vagotomy; Vasodilation | 1985 |
Effect of castration on prostaglandin-mediated changes in membrane potential and prostaglandin synthesis in guinea-pig seminal vesicle tissue.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Prostaglandins; Seminal Vesicles; Testis; Theophylline | 1985 |
Pharmacological modulation of activation-secretion of rat serosal mast cells by chymase, an endogenous secretory granule protease.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Catechols; Chymases; Deoxyadenosines; Dideoxyadenosine; Diethylcarbamazine; Dose-Response Relationship, Drug; Endopeptidases; Exocytosis; Hexosaminidases; Immunoglobulin E; In Vitro Techniques; Indomethacin; Masoprocol; Mast Cells; Prostaglandin D2; Prostaglandins D; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Serine Endopeptidases; Theophylline | 1985 |
Inhibitory effect of quinacrine on myocardial reactive hyperemia in the dog.
Topics: Acetylcholine; Adenosine; Animals; Blood Flow Velocity; Catechols; Coronary Circulation; Dogs; Female; Heart Rate; Hyperemia; Indomethacin; Male; Masoprocol; Pyrazoles; Quinacrine; Regional Blood Flow; Theophylline; Verapamil | 1985 |
Determination of rheogenic ion transport in rat proximal colon in vivo.
Topics: Alprostadil; Amiloride; Animals; Biological Transport; Colon; Epithelium; Indomethacin; Ions; Kinetics; Loperamide; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Theophylline | 1985 |
Inhibition of vasopressin-stimulated water transport across the isolated toad bladder.
Topics: Animals; Aspirin; Biochemistry; Biological Transport; Bufo marinus; Chromatography, Thin Layer; In Vitro Techniques; Indomethacin; Kinetics; Sodium; Sodium Chloride; Stimulation, Chemical; Theophylline; Tissue Extracts; Urinary Bladder; Vasopressins; Water | 1973 |
Endogenous prostaglandins modulate lipolytic processes in adipose tissue.
Topics: Acetates; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Aspirin; Cyclic AMP; Cyclopentanes; Dibenzoxazepines; Dicarboxylic Acids; Epinephrine; Fatty Acids; Hydrazines; In Vitro Techniques; Indomethacin; Lipid Metabolism; Prostaglandin Antagonists; Prostaglandins; Rats; Theophylline | 1971 |
Endogenous prostaglandins and osmotic water flow in the toad bladder.
Topics: Adenylyl Cyclase Inhibitors; Animals; Bufo marinus; Cyclic AMP; Drug Synergism; Enzyme Repression; In Vitro Techniques; Indomethacin; Osmosis; Phosphodiesterase Inhibitors; Prostaglandins; Stimulation, Chemical; Theophylline; Urinary Bladder; Vasopressins; Water | 1972 |
Indomethacin, lipolysis, and cyclic AMP accumulation in white fat cells.
Topics: Adenine; Adipose Tissue; Animals; Cyclic AMP; Fatty Acids, Nonesterified; Feedback; Female; Glycerol; Hydrogen-Ion Concentration; Indomethacin; Male; Norepinephrine; Prostaglandin Antagonists; Prostaglandins; Rats; Theophylline; Tritium | 1973 |
Effects of bradykinin and indomethacin on cyclic GMP and cyclic AMP in lung slices.
Topics: Acetylcholine; Angiotensin II; Animals; Aspirin; Bradykinin; Culture Techniques; Cyclic AMP; Cyclic GMP; Guinea Pigs; Histamine; Indomethacin; Isoproterenol; Lung; Peptides; Promethazine; Stimulation, Chemical; Theophylline | 1973 |
Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.
Topics: Adenylyl Cyclases; Animals; Aspirin; Cholera; Cyclic AMP; Drug Synergism; Enterotoxins; Enzyme Activation; Ileum; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Intestinal Secretions; Prostaglandins; Rabbits; Theophylline; Time Factors; Vibrio cholerae | 1974 |
The anti-anaphylactic actions of disodium cromoglycate, theophylline, isoprenaline and prostaglandins.
Topics: Anaphylaxis; Animals; Ascitic Fluid; Bucladesine; Cromolyn Sodium; Cytoplasmic Granules; Immune Sera; Indomethacin; Isoproterenol; Male; Mast Cells; Ovalbumin; Passive Cutaneous Anaphylaxis; Prostaglandins; Rats; Theophylline | 1974 |
Cartilage cyclic nucleotide phosphodiesterase: inhibition by anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Bucladesine; Cartilage; Cartilage, Articular; Chickens; Cyclic AMP; Cyclic GMP; Dopamine; Epinephrine; Epiphyses; Gold; Indomethacin; Kinetics; Mefenamic Acid; Oxyphenbutazone; Papaverine; Phenylbutazone; Phosphodiesterase Inhibitors; Quinolines; Structure-Activity Relationship; Sulfinpyrazone; Theophylline; Tritium | 1974 |
Cyclic AMP regulation of prostaglandin biosynthesis in fat cells.
Topics: Adipose Tissue; Animals; Arachidonic Acids; Biological Assay; Bucladesine; Chromatography, Gas; Chromatography, Thin Layer; Cyclic AMP; Depression, Chemical; Dose-Response Relationship, Drug; Fatty Acids; Indomethacin; Linolenic Acids; Lipid Metabolism; Male; Mass Spectrometry; Methods; Norepinephrine; Phospholipids; Prostaglandins; Rats; Stimulation, Chemical; Theophylline | 1974 |
Effects of prostaglandins, cyclic AMP, seminal plasma, indomethacin, and other factors on oviposition in the Japanese quail, Coturnix coturnix japonica.
Topics: Animals; Arachidonic Acids; Aspirin; Bucladesine; Cattle; Coturnix; Drug Synergism; Female; Horses; Humans; Indomethacin; Linoleic Acids; Male; Oviposition; Poultry; Propylene Glycols; Prostaglandins; Quail; Radioimmunoassay; Semen; Swine; Theophylline; Turkeys | 1974 |
Relaxation of retracted clots: a thrombelastographic study.
Topics: Aspirin; Blood Coagulation; Blood Platelets; Clot Retraction; Cyclic AMP; Humans; Indomethacin; Papaverine; Prostaglandins; Pyrimidines; Theophylline; Thrombelastography | 1974 |
[Pharmacological study of phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2 hydrochloride or fenspiride (JP 428)].
Topics: Anaphylaxis; Anesthesia; Animals; Anti-Inflammatory Agents; Atropine; Autonomic Nervous System; Bronchi; Cardiovascular System; Central Nervous System; Depression, Chemical; Dogs; Edema; Female; Guinea Pigs; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Indomethacin; Isoproterenol; Lung; Male; Methysergide; Mice; Muscle Contraction; Papaverine; Phenylbutazone; Rabbits; Rats; Spiro Compounds; Sympatholytics; Theophylline | 1969 |
Proceedings: The effects of indomethacin and theophylline on the response of frog skin to prostaglandin E1.
Topics: Animals; Anura; Biological Transport, Active; Electrophysiology; Indomethacin; Prostaglandins; Rana temporaria; Skin; Sodium; Theophylline | 1974 |
Non-steroid anti-inflammatory agents in the management of cold injury.
Topics: Animals; Anti-Inflammatory Agents; Frostbite; Hindlimb; Indomethacin; Nicotinic Acids; Oxyphenbutazone; Rabbits; Theophylline | 1972 |
Basal cyclic AMP levels in human blood mononuclear cells.
Topics: Adenosine; Adenosine Deaminase; Cyclic AMP; Humans; Indomethacin; Kinetics; Monocytes; Temperature; Theophylline | 1984 |
Chloride and sodium transport across bovine tracheal epithelium: effects of secretagogues and indomethacin.
Topics: Alprostadil; Amiloride; Animals; Biological Transport, Active; Cattle; Chlorides; Cyclic AMP; Dogs; Epinephrine; Epithelium; Indomethacin; Ion Channels; Prostaglandins E; Sodium; Theophylline; Trachea | 1984 |
Studies on the mechanism of action of glucagon in strips of rabbit renal artery.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Female; Glucagon; In Vitro Techniques; Indomethacin; Male; Papaverine; Phosphodiesterase Inhibitors; Proadifen; Rabbits; Renal Artery; Theophylline; Vasodilator Agents; Verapamil | 1980 |
[Action of adenosine 5'-triphosphate and effects of various purinergic receptor blocking agents on the movements of an isolated guinea pig gallbladder].
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Apamin; Atropine; Female; Gallbladder; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phentolamine; Propranolol; Quinidine; Receptors, Cell Surface; Receptors, Purinergic; Tetrodotoxin; Theophylline | 1983 |
[The effect of prostaglandins on steroidogenesis in isolated human and bovine adrenal cells: a study of the effect of the ACTH action mechanism (author's transl)].
Topics: 11-Hydroxycorticosteroids; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Bucladesine; Cattle; Cyclic AMP; Cycloheximide; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Prostaglandins; Prostaglandins E; Prostaglandins F; Steroids; Theophylline | 1980 |
Central effect of dibutyryl cyclic AMP on the temperature in the conscious rabbit.
Topics: Animals; Body Temperature; Brain; Bucladesine; Cyproheptadine; Drug Interactions; Fever; Hydroxydopamines; Indomethacin; Injections, Intraventricular; Male; Norepinephrine; Phenoxybenzamine; Pimozide; Rabbits; Theophylline | 1980 |
Antisecretory effects of indomethacin on rabbit ileal mucosa in vitro.
Topics: Animals; Arachidonic Acids; Calcium; Cyclic AMP; Electrolytes; Ileum; In Vitro Techniques; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Male; Prostaglandins E; Rabbits; Theophylline | 1981 |
Preventive effects of theophylline on anaphylactic shock in rats.
Topics: Anaphylaxis; Animals; Cyclic AMP; Histamine; Indomethacin; Lung; Male; Prostaglandins E; Rats; Theophylline | 1980 |
Evidence that lithium ions can modulate lectin stimulation of lymphoid cells by multiple mechanisms.
Topics: Animals; Bucladesine; Cells, Cultured; Chlorides; Concanavalin A; Cricetinae; Cyclic AMP; Female; Indomethacin; Lithium; Lithium Chloride; Lymphocyte Activation; Ouabain; Phytohemagglutinins; Sodium-Potassium-Exchanging ATPase; T-Lymphocytes; Theophylline | 1981 |
Fusion of chick embryo skeletal myoblasts: interactions of prostaglandin E1, adenosine 3':5' monophosphate, and calcium influx.
Topics: Animals; Biological Transport, Active; Calcimycin; Calcium; Cell Division; Cell Fusion; Cells, Cultured; Chick Embryo; Cyclic AMP; Egtazic Acid; Gallopamil; Indomethacin; Kinetics; Muscles; Prostaglandins E; Theophylline | 1981 |
Control of release of surfactant phospholipids in the isolated perfused rat lung.
Topics: Albuterol; Animals; Atropine; Bucladesine; Cyproheptadine; Dibutyryl Cyclic GMP; Hyperventilation; Indomethacin; Lung; Male; Perfusion; Phospholipids; Pilocarpine; Pulmonary Surfactants; Rats; Respiration; Tetrodotoxin; Theophylline | 1981 |
Tolerance of guinea-pig airway muscle preparations to relaxant agonists induced by chronic exposure to isoprenaline in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Female; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Isoproterenol; Muscle Contraction; Muscle Relaxation; Parasympatholytics; Prostaglandins; Receptors, Adrenergic, beta; Theophylline; Trachea | 1981 |
The ontogeny of the thyrotropin-thyroid axis in early bovine embryos.
Topics: Adenosine; Animals; Bucladesine; Cattle; Dinoprostone; Embryo, Mammalian; Female; Gestational Age; Indomethacin; Kinetics; Male; Pregnancy; Prostaglandins E; Theophylline; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1981 |
Hormonal control of the Na entry process at the apical membrane of frog skin.
Topics: Amiloride; Animals; Biological Transport, Active; Cell Membrane; Indomethacin; Ion Channels; Kinetics; Membrane Potentials; Ranidae; Skin; Sodium; Theophylline; Vasopressins | 1981 |
Actions of indomethacin and prostaglandins E2 and D2 on nerve transmission in the nictitating membrane of the cat.
Topics: Animals; Atropine; Blood Pressure; Cats; Dinoprostone; Female; Heart Rate; Indomethacin; Injections, Intra-Arterial; Male; Nictitating Membrane; Prostaglandins; Prostaglandins D; Prostaglandins E; Regional Blood Flow; Synaptic Transmission; Theophylline | 1981 |
Pharmacological characterization of purinergic receptors in the rat vas deferens.
Topics: Adenosine; Animals; Electric Stimulation; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Vas Deferens | 1983 |
Direct effects of adenosine and adenine nucleotides on isolated human urinary bladder and their influence on electrically induced contractions.
Topics: Acetylcholine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Adult; Aged; Atropine; Dipyridamole; Electric Stimulation; Female; Humans; In Vitro Techniques; Indomethacin; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Prostaglandins; Purines; Synaptic Transmission; Theophylline; Urinary Bladder | 1983 |
Contractile reaction of isolated frog aorta after X-irradiation.
Topics: Animals; Aorta; Atropine; Cyclic AMP; Indomethacin; Methysergide; Muscle Contraction; Muscle, Smooth; Phentolamine; Propranolol; Radiation Dosage; Rana esculenta; Theophylline | 1983 |
Inhibitors of prostaglandin synthesis block the induction of staphylococcal enterotoxin B-activated T-suppressor cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Catechols; Cells, Cultured; Cyclic AMP; Enterotoxins; Imidazoles; Indomethacin; Lymphocyte Activation; Male; Masoprocol; Mice; Mice, Inbred BALB C; Prostaglandins; Pyrogallol; T-Lymphocytes, Regulatory; Theophylline | 1983 |
Hormonal control of apical membrane Na transport in epithelia. Studies with fluctuation analysis.
Topics: Amiloride; Animals; Epithelium; In Vitro Techniques; Indomethacin; Ion Channels; Membrane Potentials; Prostaglandins; Rana pipiens; Skin; Skin Physiological Phenomena; Sodium; Theophylline; Vasopressins | 1983 |
Chloride secretion by canine tracheal epithelium: I. Role of intracellular c AMP levels.
Topics: Acetylcholine; Animals; Biological Transport, Active; Calcium; Chlorides; Cyclic AMP; Dinoprostone; Dogs; Epithelium; In Vitro Techniques; Indomethacin; Membrane Potentials; Prostaglandins E; Prostaglandins, Synthetic; Theophylline; Trachea | 1982 |
Cholecystokinin-octapeptide-induced hyperthermia in guinea-pigs.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Injections, Intraventricular; Male; Naloxone; Phenoxybenzamine; Sincalide; Theophylline | 1983 |
Hyperthermic effects of centrally injected (D-ala2, N-Me-Phe4, Met-(O)5-ol)-enkephalin (FK 33-824) in rabbits and guinea-pigs.
Topics: Animals; Body Temperature; Cyclic AMP; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Guinea Pigs; Indomethacin; Injections, Intraventricular; Male; Naloxone; Norepinephrine; Phenoxybenzamine; Prostaglandins; Rabbits; Theophylline | 1983 |
Prostaglandin E2, adenosine 3':5'-cyclic monophosphate and changes in endometrial vascular permeability in rat uteri sensitized for the decidual cell reaction.
Topics: Animals; Bucladesine; Capillary Permeability; Cholera Toxin; Cyclic AMP; Decidua; Dinoprostone; Endometrium; Female; Indomethacin; Prostaglandins E; Rats; Rats, Inbred Strains; Theophylline; Uterus | 1983 |
Regulation of pyruvate kinase expression and growth in P-815 mastocytoma cells. II. Potential role of prostaglandins.
Topics: Animals; Bucladesine; Butyrates; Butyric Acid; Dinoprost; Dinoprostone; Drug Synergism; Indomethacin; Mast-Cell Sarcoma; Mice; Prostaglandins; Prostaglandins E; Prostaglandins F; Pyruvate Kinase; Theophylline | 1984 |
Spontaneous and provoked resistance to isoproterenol in isolated human bronchi.
Topics: Airway Resistance; Anti-Inflammatory Agents; Bronchi; Female; Humans; Indomethacin; Isoproterenol; Male; Theophylline | 1984 |
A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat.
Topics: Animals; Carrageenan; Dexamethasone; Dose-Response Relationship, Drug; Edema; Hindlimb; Indomethacin; Male; Muscles; Phentolamine; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Theophylline; Verapamil; Yohimbine | 1984 |
Relaxation of rings of canine cerebral artery produced by adenosine and its analogues.
Topics: Adenosine; Animals; Apamin; Cerebral Arteries; Dogs; Female; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth, Vascular; Serotonin; Theophylline; Vasodilation | 1984 |
Dissociation of effects of xanthine analogs on renal prostaglandins and renal excretory function in the awake rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Consciousness; Dinoprost; Dinoprostone; Diuresis; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Kidney; Male; Meclofenamic Acid; Natriuresis; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Xanthines | 1983 |
Adenosine and ATP effects on isolated guinea pig gallbladder.
Topics: Adenosine; Adenosine Triphosphate; Animals; Culture Techniques; Drug Interactions; Gallbladder; Guanosine; Guinea Pigs; Indomethacin; Muscle Contraction; Muscle, Smooth; Theophylline; Thionucleosides | 1983 |
Hyperthermic responses to central injections of some peptide and non-peptide opioids in the guinea-pig.
Topics: Animals; Body Temperature; Endorphins; Fever; Guinea Pigs; Indomethacin; Iodipamide; Naloxone; Narcotics; Norepinephrine; Phenoxybenzamine; Theophylline | 1983 |
Vasopressin, theophylline, PGE2, and indomethacin on active Na transport in frog skin: studies with microelectrodes.
Topics: Animals; Biological Transport, Active; Dinoprostone; Indomethacin; Kinetics; Microelectrodes; Prostaglandins E; Rana pipiens; Skin; Sodium; Theophylline; Vasopressins | 1981 |
Inhibition by nicotine of the formation of prostacyclin-like activity in rabbit and human vascular tissue.
Topics: Adenosine Diphosphate; Animals; Blood Vessels; Epoprostenol; Female; Humans; In Vitro Techniques; Indomethacin; Male; Nicotine; Platelet Aggregation; Prostaglandins; Rabbits; Species Specificity; Theophylline | 1980 |
Inhibitory effect of adenosine and adenine nucleotides on potassium-evoked efflux of [3H]-noradrenaline from the rat isolated heart: lack of relationship to prostaglandins.
Topics: Adenine Nucleotides; Adenosine; Animals; Calcium; In Vitro Techniques; Indomethacin; Male; Myocardium; Norepinephrine; Potassium; Prostaglandins; Rats; Rats, Inbred Strains; Theophylline; Tritium; Tyramine | 1980 |
Effects of methylxanthines on urinary prostaglandin E excretion in rats.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Electrolytes; Indomethacin; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1981 |
Prostaglandins as mediators of bone resorption in renal and breast tumours.
Topics: Animals; Biological Assay; Bone Resorption; Breast Neoplasms; Culture Techniques; Female; Humans; Indomethacin; Kidney Neoplasms; Mice; Prostaglandins E; Prostaglandins F; Theophylline | 1980 |
Differential effects of ATP- and 2-methylthioATP-induced relaxation in guinea pig coronary vasculature.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Coronary Vessels; Electrophysiology; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Purinergic Antagonists; Theophylline; Thionucleotides | 1994 |
Polystyrene microspheres decrease bronchial artery resistance in anesthetized sheep.
Topics: Animals; Blood Pressure; Bronchial Arteries; Dose-Response Relationship, Drug; Indomethacin; Injections; Microspheres; Polystyrenes; Regional Blood Flow; Theophylline; Vascular Resistance | 1995 |
Studies on the inhibition of rejection of Trichostrongylus colubriformis larvae from immune sheep.
Topics: Animals; Azepines; Chlorpheniramine; Cyclosporine; Dexamethasone; Indomethacin; Larva; Piroxicam; Rejection, Psychology; Sheep; Sheep Diseases; Theophylline; Triazoles; Trichostrongylosis; Trichostrongylus | 1995 |
Nitric oxide is a major mediator in reactive hyperaemia evoked by a brief coronary occlusion in the guinea pig heart.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Coronary Vessels; Female; Guinea Pigs; Hyperemia; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Theophylline; Ventricular Function, Left; Ventricular Pressure | 1993 |
Role of endothelium in hyperpolarization of coronary smooth muscle by adenosine and its analogues.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; In Vitro Techniques; Indomethacin; Membrane Potentials; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Swine; Theophylline; Vasodilator Agents | 1995 |
Further investigations into adenosine A1 receptor-mediated contraction in rat colonic muscularis mucosae and its augmentation by certain alkylxanthine antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colon; Cyclooxygenase Inhibitors; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Theophylline; Triazoles; Vasodilator Agents; Xanthines | 1995 |
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Endothelium, Vascular; Glyburide; Glycolysis; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Theophylline; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1994 |
Alpha 2-adrenergic receptors of the alpha 2c subtype mediate inhibition of norepinephrine release in human kidney cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Kidney Cortex; Norepinephrine; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha-2; Theophylline | 1994 |
The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxamidoadenosine and N6-cyclopentyladenosine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Renal Artery; Renal Circulation; Theophylline; Vasodilator Agents; Xanthines | 1994 |
Adenosine induces contractions in suncus ileum.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Primates; Receptors, Purinergic; Theophylline | 1993 |
Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs.
Topics: Animals; Animals, Newborn; Cell Membrane Permeability; Cold Temperature; Dose-Response Relationship, Drug; Enterocolitis, Pseudomembranous; Hypoxia; Indomethacin; Intestinal Mucosa; Intestines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stress, Physiological; Theophylline | 1993 |
Diffusion and concentration profiles of drugs in gels.
Topics: Acetaminophen; Chlorpheniramine; Diffusion; Gels; Humans; Ibuprofen; Indomethacin; Pharmacokinetics; Temperature; Theophylline | 1993 |
A2-purinoceptor-mediated relaxation in the guinea-pig coronary vasculature: a role for nitric oxide.
Topics: Adenosine; Animals; Antihypertensive Agents; Arginine; Coronary Vessels; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenethylamines; Prostaglandins; Receptors, Purinergic; Theophylline; Vasodilation; Xanthines | 1993 |
Relaxant effects of nucleotides in guinea pig isolated, perfused trachea: lack of involvement of prostanoids, Cl- channels and adenosine.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine; Adenosine Triphosphate; Animals; Chloride Channels; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Proteins; Mucous Membrane; Muscle Relaxation; Muscle, Smooth; Nucleotides; Prostaglandins; Theophylline; Trachea; Uridine Triphosphate | 1993 |
Effect of adenosine 5'-triphosphate on secretagogue-stimulated (14C)-aminopyrine accumulation by rabbit isolated gastric glands.
Topics: Adenosine Triphosphate; Aminopyrine; Animals; Bucladesine; Carbachol; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Indomethacin; Perfusion; Rabbits; Theophylline | 1993 |
Pharmacological modulation of the spasmogenic response to methylxanthines in guinea-pig trachea.
Topics: Animals; Caffeine; Calcium; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Protein Kinase C; Sodium; Theophylline; Trachea; Xanthines | 1993 |
Adenosine is a mediator of ethanol-induced gastric vasodilation in dogs.
Topics: Adenosine; Animals; Cimetidine; Dogs; Ethanol; Histamine; Indomethacin; Male; Muscle, Smooth; Purinergic Antagonists; Pyrilamine; Regional Blood Flow; Stomach; Theophylline; Vascular Resistance; Vasodilation | 1993 |
Effect of diadenosine phosphates on human umbilical vessels: novel platelet-derived vasoconstrictors.
Topics: Arginine; Blood Platelets; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; omega-N-Methylarginine; Theophylline; Umbilical Arteries; Vasoconstrictor Agents | 1995 |
Enhancing effect of platelets on staphylokinase-mediated clot lysis and plasminogen activation.
Topics: Blood Platelets; Fibrinolysis; Fibrinolytic Agents; Humans; Indomethacin; Metalloendopeptidases; Plasminogen; Platelet Count; Theophylline | 1995 |
Pathways mediating pentagastrin-induced mucosal blood flow response in rat stomachs.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Drug Interactions; Gastric Acid; Gastric Mucosa; Glycine; Indomethacin; Male; Omeprazole; Pentagastrin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Theophylline | 1996 |
P2-purinoceptors mediating spasm of the isolated uterus of the non-pregnant guinea-pig.
Topics: Adenosine Triphosphate; Animals; Female; Guinea Pigs; Indomethacin; Muscle Contraction; Muscle, Smooth; Platelet Aggregation Inhibitors; Pyridoxal Phosphate; Receptors, Purinergic P1; Receptors, Purinergic P2; Spasm; Suramin; Theophylline; Thioinosine; Thionucleotides; Uridine Triphosphate; Uterus | 1996 |
Study of post-natal effect of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. III. Inhibitory action of indomethacin, voltaren, theophylline and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Animals; Anticarcinogenic Agents; Brain Neoplasms; Carcinogens; Central Nervous System Neoplasms; Diclofenac; Ethylnitrosourea; Female; Indomethacin; Kidney Neoplasms; Maternal-Fetal Exchange; Neoplasms, Experimental; Peripheral Nervous System Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Spinal Cord Neoplasms; Theophylline | 1996 |
ATP and beta,gamma-methylene ATP produce relaxation of guinea-pig isolated trachealis muscle via actions at P1 purinoceptors.
Topics: Adenosine Triphosphate; Animals; Carbachol; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Parasympatholytics; Receptors, Purinergic P1; Receptors, Purinergic P2; Suramin; Theophylline; Thioinosine; Trachea | 1996 |
Ischaemic cardiac hyperaemia: role of nitric oxide and other mediators.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Animals; Coronary Circulation; Cyclic GMP; Cyclooxygenase Inhibitors; Electrocardiography; Endothelins; Epoprostenol; Guinea Pigs; Hyperemia; In Vitro Techniques; Indomethacin; Myocardial Ischemia; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Perfusion; Prostaglandin Antagonists; Purinergic P1 Receptor Antagonists; Purines; Theophylline | 1996 |
P1-purinoceptor-mediated vasodilatation and vasoconstriction in hypoxia.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Guinea Pigs; Hypoxia; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenethylamines; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Vasoconstriction; Vasodilation | 1996 |
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Indomethacin; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Reperfusion Injury; Swine; Theophylline; Vasodilator Agents | 1997 |
Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production.
Topics: Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Culture Media; Cytokines; Female; Immunohistochemistry; Indomethacin; Interferon-gamma; Interleukin-10; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Organophosphonates; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Stimulation, Chemical; Tenofovir; Theophylline; Tumor Necrosis Factor-alpha | 1997 |
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Glyburide; Hyperemia; Indomethacin; NG-Nitroarginine Methyl Ester; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Theophylline | 1997 |
On the mechanisms of adenosine induced pulmonary vasoconstriction in rats.
Topics: Adenosine; Adrenergic Antagonists; Animals; Cyclooxygenase Inhibitors; Cyproheptadine; Dihydroergotoxine; Endothelium, Vascular; Female; Flavonoids; Ginkgo biloba; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Plant Extracts; Platelet Activating Factor; Pulmonary Artery; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Quinidine; Rats; Rats, Sprague-Dawley; Theophylline; Vasoconstriction | 1997 |
Acute defense mechanisms against hemorrhage from mechanical gill injury in rainbow trout.
Topics: Animals; Arteries; Atropine; Cholinergic Antagonists; Gills; Hematocrit; Hemorrhage; Hemostatics; Indomethacin; Methysergide; Oncorhynchus mykiss; Purinergic P1 Receptor Antagonists; Serotonin Antagonists; Tetrodotoxin; Theophylline; Vasoconstriction; Vasoconstrictor Agents | 1998 |
A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Indomethacin; Male; Muscle Relaxation; Receptors, Purinergic P1; Swine; Synaptic Transmission; Theophylline; Ureter; Xanthines | 1999 |
Alginate-pectin-poly-L-lysine particulate as a potential controlled release formulation.
Topics: Adhesiveness; Alginates; Animals; Caco-2 Cells; Capsules; Chlorothiazide; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Drug Delivery Systems; Gelatin; Glucuronic Acid; Hexuronic Acids; Humans; Hydrogen-Ion Concentration; Indomethacin; Male; Microscopy, Electron, Scanning Transmission; Particle Size; Pectins; Polylysine; Rats; Rats, Wistar; Theophylline; Time Factors | 1999 |
Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity.
Topics: Animals; Chromatography, High Pressure Liquid; Esterases; gamma-Linolenic Acid; Humans; Hydrolysis; Indomethacin; Kinetics; Liver; Pentanoic Acids; Phenytoin; Prodrugs; Structure-Activity Relationship; Swine; Theophylline | 1999 |
A retinal-derived relaxing factor mediates the hypoxic vasodilation of retinal arteries.
Topics: Animals; Cattle; Cyclooxygenase Inhibitors; Dinoprost; Electromyography; Eye Proteins; Hydrogen-Ion Concentration; Hypoxia; Indomethacin; Muscle Proteins; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Purinergic P1 Receptor Antagonists; Retina; Retinal Artery; Theophylline; Vasodilation | 2000 |
Mechanism of prolonged vasorelaxation to ATP in the rat isolated mesenteric arterial bed.
Topics: Adenosine Triphosphate; Animals; Capsaicin; Cardiotonic Agents; Cardiovascular Agents; Charybdotoxin; Drug Interactions; Electric Stimulation; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Isotonic Solutions; Male; Mesenteric Arteries; Neurons, Afferent; Ouabain; Pyridoxal Phosphate; Rats; Rats, Wistar; Suramin; Tetraethylammonium; Theophylline; Vasodilation | 2001 |
Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves.
Topics: Adenosine; Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Denervation; Digestive System; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Gene Expression Regulation, Enzymologic; Indomethacin; Ischemic Preconditioning; Isoenzymes; Lactones; Male; Membrane Proteins; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Regional Blood Flow; Reperfusion Injury; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Sulfones; Theophylline; Time Factors | 2001 |
Chronic estrogen depletion alters adenosine diphosphate-induced pial arteriolar dilation in female rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antifungal Agents; Arterioles; Calcium; Cardiovascular Agents; Endothelium, Vascular; Estrogens; Female; Glyburide; Hypoglycemic Agents; Indomethacin; Miconazole; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Ovariectomy; Peptides; Pia Mater; Potassium Channels; Rats; Rats, Sprague-Dawley; Theophylline; Vasodilation | 2001 |
Comparative study of the contractile activity evoked by ATP and diadenosine tetraphosphate in isolated rat urinary bladder.
Topics: Adenosine Triphosphate; Animals; Atropine; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Rats; Rats, Wistar; Theophylline; Urinary Bladder | 2002 |
Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies.
Topics: Adenosine; Animals; Aorta; Cyclooxygenase Inhibitors; Diclofenac; Hypoxia; In Vitro Techniques; Indomethacin; Male; Muscle, Skeletal; Nitric Oxide; Prostaglandins; Rats; Rats, Wistar; Theophylline; Vasodilation | 2002 |
Potential of carrageenans to protect drugs from polymorphic transformation.
Topics: Carrageenan; Cellulose; Chemistry, Pharmaceutical; Crystallization; Excipients; Hypromellose Derivatives; Indomethacin; Methylcellulose; Models, Chemical; Powders; Spectrum Analysis, Raman; Tablets; Theophylline | 2003 |
Use of glancing angle X-ray powder diffractometry to depth-profile phase transformations during dissolution of indomethacin and theophylline tablets.
Topics: Drug Stability; Indomethacin; Phase Transition; Powders; Solubility; Tablets; Theophylline; X-Ray Diffraction | 2004 |
The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Isoenzymes; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rolipram; Theophylline; Trachea | 2004 |
Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Down-Regulation; Ileitis; Indomethacin; Inflammation; Jejunal Diseases; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Theophylline; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Permeability and swelling studies on free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery.
Topics: Acrylic Resins; Chemistry, Pharmaceutical; Colon; Delayed-Action Preparations; Drug Carriers; Hydrogen-Ion Concentration; Indomethacin; Inulin; Particle Size; Permeability; Polymers; Polymethacrylic Acids; Solubility; Technology, Pharmaceutical; Theophylline; Time Factors; Water | 2006 |
Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines.
Topics: 5'-Nucleotidase; Actins; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Gene Expression Regulation, Enzymologic; Glioma; Humans; Indomethacin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Time Factors; Triazoles; Xanthines | 2007 |
Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination.
Topics: Adenine; Administration, Cutaneous; Alanine; Animals; Caproates; Chemistry, Pharmaceutical; Dimethylamines; Dodecanol; Drug Carriers; Drug Compounding; Drug Stability; Electric Impedance; Esterases; Halogenation; Hydrocortisone; Hydrolysis; Indomethacin; Isomerism; Methylamines; Molecular Structure; Organophosphonates; Skin; Skin Absorption; Structure-Activity Relationship; Swine; Theophylline; Time Factors | 2009 |
Modulation of butyrate transport in Caco-2 cells.
Topics: 2,4-Dinitrophenol; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetaldehyde; Acids, Acyclic; Aspirin; Biological Transport, Active; Butyrates; Caco-2 Cells; Caffeine; Cell Survival; Dronabinol; Gene Expression; Humans; Hydrogen-Ion Concentration; Indomethacin; Ions; Kinetics; Monocarboxylic Acid Transporters; N-Methyl-3,4-methylenedioxyamphetamine; Sodium Azide; Symporters; Theophylline | 2009 |
Short-chain ceramides decrease skin barrier properties.
Topics: Animals; Ceramides; Indomethacin; Molecular Structure; Permeability; Skin; Skin Absorption; Structure-Activity Relationship; Swine; Theophylline | 2009 |
ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine.
Topics: Adenosine; Adenosine Triphosphate; Adult; Blood Flow Velocity; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indomethacin; Infusions, Intra-Arterial; Lower Extremity; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Prostaglandins; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y2; Regional Blood Flow; RNA, Messenger; Signal Transduction; Theophylline; Vasodilation; Young Adult | 2009 |
Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation.
Topics: Adenosine; Adult; Analysis of Variance; Cohort Studies; Exercise; Humans; Hyperemia; Indomethacin; Leg; Male; Muscle, Skeletal; Nitric Oxide; omega-N-Methylarginine; Prostaglandins; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Reference Values; Regional Blood Flow; Sensitivity and Specificity; Theophylline; Vasodilation; Young Adult | 2009 |
Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages.
Topics: Acetaminophen; Animals; Anthracenes; Cell Line; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Indomethacin; Interleukin-1beta; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mice; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction; Theophylline; Tumor Necrosis Factor-alpha | 2009 |
Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ceramides; Hot Temperature; Humans; Indomethacin; Models, Chemical; Permeability; Phosphodiesterase Inhibitors; Skin; Sphingosine; Theophylline | 2011 |
A discriminatory intrinsic dissolution study using UV area imaging analysis to gain additional insights into the dissolution behaviour of active pharmaceutical ingredients.
Topics: Chemistry, Pharmaceutical; Drug Design; Ibuprofen; Indomethacin; Sodium Dodecyl Sulfate; Solubility; Spectrum Analysis, Raman; Technology, Pharmaceutical; Theophylline; Ultraviolet Rays; X-Ray Diffraction | 2012 |
Detection of cocrystal formation based on binary phase diagrams using thermal analysis.
Topics: Caffeine; Calorimetry, Differential Scanning; Camphor; Carbamazepine; Crystallization; Heating; Indomethacin; Niacinamide; Pharmaceutical Preparations; Phase Transition; Piroxicam; Powder Diffraction; Salicylic Acid; Theophylline; X-Ray Diffraction | 2013 |
Cross-validation for nonlinear mixed effects models.
Topics: Computer Simulation; Indomethacin; Models, Biological; Nonlinear Dynamics; Theophylline | 2013 |
Evaluation of changes in oral drug absorption in preterm and term neonates for Biopharmaceutics Classification System (BCS) class I and II compounds.
Topics: Acetaminophen; Administration, Oral; Biopharmaceutics; Humans; Ibuprofen; Indomethacin; Infant, Newborn; Infant, Premature; Intestinal Absorption; Theophylline | 2016 |
Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Anticonvulsants; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Fourier Analysis; Guanosine; Indomethacin; Lipopolysaccharides; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Theophylline; Time Factors; Triazoles | 2016 |
Permeability Barrier and Microstructure of Skin Lipid Membrane Models of Impaired Glucosylceramide Processing.
Topics: Administration, Topical; Cell Membrane Permeability; Ceramides; Electric Impedance; Female; Glucosylceramides; Humans; Indomethacin; Membrane Lipids; Permeability; Skin; Spectroscopy, Fourier Transform Infrared; Theophylline; X-Ray Diffraction | 2017 |
Simplified stratum corneum model membranes for studying the effects of permeation enhancers.
Topics: Administration, Cutaneous; Animals; Azepines; Ceramides; Cholesterol; Humans; Indomethacin; Membrane Lipids; Membranes, Artificial; Permeability; Skin; Skin Absorption; Stearic Acids; Swine; Theophylline | 2017 |