theophylline and hydroxyurea

theophylline has been researched along with hydroxyurea in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (33.33)	18.7374
1990's	9 (27.27)	18.2507
2000's	6 (18.18)	29.6817
2010's	7 (21.21)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bar-Eli, M; Callily, R; Cohen, H; Wahba, A	1
Cordell, SL; Lawrence, HS; Young, JM	1
Reiter, RS; Solursh, M	1
Rasmont, R	1
Alford, BL; Barnes, EM	1
Gill, GN; Weidman, ER	1
Warrington, RC	1
Bantle, JA; Dawson, DA	1
Bedford, JS; Bender, MA; Griggs, HG	1
Halprin, KM; Levine, V; Taylor, JR	1
DiPaolo, JA; Epstein, SM; Mironescu, SG	1
Bopp, BA; Kukulka, MJ; Machinist, JM	1
Awni, WM; Braeckman, RA; Cavanaugh, JH; Dubé, LM; Granneman, GR; Locke, CS	1
Ferrero, JL; Machinist, JM; Mayer, MD; Rodrigues, AD; Shet, MS	1
Bell, RL; Carter, GW; Goodfellow, C; Harris, RR; Namovic, MT; Walsh, RE	1
Lau, R	1
Dubé, LM; Lancaster, JF; Petty, T; Schwartz, HJ; Swanson, LJ	1
Awni, WM; Cavanaugh, JH; Hansen, R; Qian, J; Wong, SL	1

Reviews

3 review(s) available for theophylline and hydroxyurea

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Freshwater sponges as a material for the study of cell differentiation. Current topics in developmental biology, 1975, Volume: 10 Topics: Animals; Cell Aggregation; Cell Differentiation; Chemotaxis; Culture Techniques; Cyclic AMP; DNA; Ecology; Hibernation; Hydroxyurea; Osmotic Pressure; Porifera; Reproduction, Asexual; Silicon Dioxide; Theophylline	1975
Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation. Mutation research, 1974, Volume: 23, Issue:2 Topics: Alkylating Agents; Animals; Caffeine; Chromosome Aberrations; Cyanides; Cytarabine; Deoxyadenosines; DNA; DNA Repair; DNA Replication; DNA, Single-Stranded; Floxuridine; Hydroxyurea; Mitosis; Models, Biological; Mutagens; Radiation Genetics; Recombination, Genetic; Streptonigrin; Theobromine; Theophylline	1974

Trials

4 trial(s) available for theophylline and hydroxyurea

Article	Year
Effect of zileuton on theophylline pharmacokinetics. Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2 Topics: Administration, Oral; Adult; Analysis of Variance; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Half-Life; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Theophylline	1995
Drug interactions with zileuton. Lancet (London, England), 1997, May-17, Volume: 349, Issue:9063 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Bronchodilator Agents; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Theophylline; Warfarin	1997
A randomized controlled trial comparing zileuton with theophylline in moderate asthma. The Zileuton Study Group. Archives of internal medicine, 1998, Jan-26, Volume: 158, Issue:2 Topics: Adult; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Lung Volume Measurements; Male; Middle Aged; Severity of Illness Index; Theophylline; Time Factors; Treatment Outcome	1998
Lack of cytochrome P450 1A2 interaction effect of ABT-761 on the pharmacokinetics of theophylline. American journal of therapeutics, 1998, Volume: 5, Issue:5 Topics: Adult; Cytochrome P-450 CYP1A2; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Metabolic Clearance Rate; Theophylline	1998

Other Studies

26 other study(ies) available for theophylline and hydroxyurea

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Neutrophil chemotaxis in psoriasis. Acta dermato-venereologica, 1979, Volume: 59, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aged; Chemotaxis, Leukocyte; Child; Cyclic AMP; Cyclic GMP; Epidermis; Ethylenediamines; Female; Humans; Hydroxyurea; Male; Methotrexate; Middle Aged; Neutrophils; Phosphodiesterase Inhibitors; Psoriasis; Skin; Theophylline	1979
In vitro epidermal cell proliferation in rat skin plugs. The Journal of investigative dermatology, 1975, Volume: 64, Issue:1 Topics: Aminophylline; Animals; Autoradiography; Bucladesine; Cell Division; Demecolcine; Depression, Chemical; DNA; Epinephrine; Hydroxyurea; Isoproterenol; Male; Mitosis; Models, Biological; Rats; Skin; Theophylline; Thymidine; Time Factors; Tritium; Wound Healing	1975
Determination of limb bud chondrocytes during a transient block of the cell cycle. Cell differentiation, 1975, Volume: 4, Issue:3 Topics: Aminopterin; Animals; Bucladesine; Cartilage; Cell Adhesion; Cell Differentiation; Cell Division; Cells, Cultured; Chick Embryo; Colchicine; Cytarabine; DNA; Extremities; Floxuridine; Hydroxyurea; Theophylline; Thymidine	1975
Regulation of hypoxanthine transport by cyclic nucleotides in cultured Chinese hamster lung fibroblasts. Archives of biochemistry and biophysics, 1977, Apr-15, Volume: 180, Issue:1 Topics: Bucladesine; Cells, Cultured; Cyclic GMP; Cycloheximide; Dactinomycin; DNA; Fibroblasts; Glucagon; Hydroxyurea; Hypoxanthines; Insulin; Nucleotides, Cyclic; Theophylline; Thymidine; Xanthines	1977
Hormonal regulation of initiation of DNA synthesis and of differentiated function in Y-1 adrenal cortical cells. Journal of cellular physiology, 1977, Volume: 92, Issue:1 Topics: 20-alpha-Dihydroprogesterone; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Animals; Blood; Bromine; Cattle; Cell Division; Cell Line; Cells, Cultured; Culture Media; Cyclic AMP; DNA, Neoplasm; Hydroxyprogesterones; Hydroxyurea; Mice; Progesterone; Theophylline	1977
Selective killing of oncogenic human cells cocultivated with normal human fibroblasts. Journal of the National Cancer Institute, 1978, Volume: 61, Issue:1 Topics: Cell Cycle; Cell Survival; Cells, Cultured; Cytarabine; Fibroblasts; HeLa Cells; Histidinol; Humans; Hydroxyurea; Imidazoles; Theophylline	1978
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos. Teratology, 1987, Volume: 35, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, Nonmammalian; Emetine; Fluorouracil; Hydroxyurea; Theobromine; Theophylline; Xanthines; Xenopus laevis	1987
Inhibitors of epidermal cell DNA synthesis in surviving pig skin in vitro. The Journal of investigative dermatology, 1980, Volume: 74, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cell Division; Cyclic AMP; DNA; Epidermal Cells; Epidermis; Epinephrine; Histamine; Hydroxyurea; In Vitro Techniques; Swine; Theophylline	1980
Relationship between morphological transformation and [3H]thymidine incorporation stimulated by a chemical carcinogen in postconfluent cultures of hamster embryo cells. Cancer research, 1980, Volume: 40, Issue:7 Topics: Animals; Autoradiography; Caffeine; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Hydroxyurea; Mesocricetus; Methylnitronitrosoguanidine; Stimulation, Chemical; Theophylline; Thymidine	1980
In vitro plasma protein binding of zileuton and its N-dehydroxylated metabolite. Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2 Topics: Adult; Anti-Allergic Agents; Anti-Inflammatory Agents; Anticoagulants; Blood Proteins; Chromatography, High Pressure Liquid; Drug Interactions; Female; Hematocrit; Humans; Hydroxylation; Hydroxyurea; Ibuprofen; In Vitro Techniques; Isotope Labeling; Lipoxygenase Inhibitors; Male; Naproxen; Prednisolone; Protein Binding; Salicylates; Stereoisomerism; Terfenadine; Theophylline; Warfarin	1995
Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:10 Topics: Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Hydroxyurea; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Microsomes, Liver; Propranolol; Theophylline; Urea	1995
Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats. European journal of pharmacology, 1996, Nov-07, Volume: 315, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Calcimycin; Dextrans; Eosinophils; Hydroxyurea; Ionophores; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pulmonary Eosinophilia; Rats; Theophylline	1996
Zileuton for asthma. The Medical letter on drugs and therapeutics, 1997, Feb-28, Volume: 39, Issue:995 Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Intestinal Absorption; Leukotrienes; Lipoxygenase Inhibitors; Propranolol; Theophylline; Warfarin	1997
Drugs for asthma. The Medical letter on drugs and therapeutics, 1999, Jan-15, Volume: 41, Issue:1044 Topics: Acetates; Administration, Inhalation; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bone Density; Bronchial Spasm; Bronchodilator Agents; Child; Child, Preschool; Choice Behavior; Cromolyn Sodium; Cyclopropanes; Exercise; Female; Growth; Humans; Hydroxyurea; Indoles; Infant, Newborn; Ipratropium; Lactation; Leukotriene Antagonists; Phenylcarbamates; Pregnancy; Pregnancy Complications; Quinolines; Salmeterol Xinafoate; Sulfides; Sulfonamides; Tachycardia; Theophylline; Tosyl Compounds	1999
Drugs for asthma. The Medical letter on drugs and therapeutics, 2000, Mar-06, Volume: 42, Issue:1073 Topics: Acetates; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Spasm; Child; Cromolyn Sodium; Cyclopropanes; Exercise; Female; Growth Disorders; Humans; Hydroxyurea; Indoles; Ipratropium; Lactation; Leukotriene Antagonists; Nebulizers and Vaporizers; Nedocromil; Phenylcarbamates; Pregnancy; Pregnancy Complications; Quinolines; Salmeterol Xinafoate; Sulfides; Sulfonamides; Theophylline; Tosyl Compounds	2000