theophylline has been researched along with furafylline in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.19) | 18.7374 |
| 1990's | 27 (35.06) | 18.2507 |
| 2000's | 33 (42.86) | 29.6817 |
| 2010's | 12 (15.58) | 24.3611 |
| 2020's | 1 (1.30) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Lewis, I; Murray, BP; Rendell, NB; Rich, KJ | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Murray, BP; Murray, S | 1 |
| Boobis, AR; Davies, DS; de la Torre, R; Murray, BP; Murray, S; Segura, J; Sesardic, D | 1 |
| Roberts, DJ; Segura, J; Tarrus, E | 1 |
| Garcia, I; Segura, J; Tarrus, E | 1 |
| García, I; Roberts, DJ; Segura, J; Tarrús, E | 1 |
| Cami, J; Celdran, E; Roberts, DJ; Segura, J; Spickett, RG; Tarrus, E | 1 |
| Fuhr, U; Pfleiderer, W | 1 |
| Birkett, DJ; McManus, ME; Miners, JO; Tassaneeyakul, W; Tukey, RH; Veronese, ME | 1 |
| Ayrton, AD; Chenery, RJ; Clarke, SE | 1 |
| Burke, MD; Mayer, RT; Thompson, S; Weaver, RJ; Wolf, CR | 1 |
| Eaton, DL; Gallagher, EP; Kunze, KL; Stapleton, PL; Wienkers, LC | 1 |
| Boobis, AR; Davies, DS; de la Torre, R; Farré, M; Gooderham, NJ; Lynch, AM; Murray, S; Segura, J; Solans, A | 1 |
| Gelboin, HV; Goldfarb, IS; Tsyrlov, IB | 1 |
| Bayliss, MK; Eddershaw, PJ; Herriott, D; Manchee, GR; Park, GR; Ranshaw, LE; Tarbit, MH | 1 |
| Kunze, KL; Rettie, AE; Storch, E; Trager, WF; Wienkers, LC; Wurden, CJ | 1 |
| Boobis, AR; Davies, DS; de la Torre, R; Gooderham, NJ; Lynch, A; Murray, S; Segura, J | 1 |
| Binkley, SN; Ring, BJ; VandenBranden, M; Wrighton, SA | 1 |
| Feierman, DE; Lasker, JM | 1 |
| Bezek, S; Kukan, M; Pool, WF; Woolf, TF | 1 |
| Davies, DS; Edwards, RJ; Neubert, D; Schulz, TG | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Lynch, AM; Murray, S; Rich, K; Yadollahi-Farsani, M; Zhao, K | 1 |
| Jones, BC; Smith, DA; Tyman, CA | 1 |
| Back, DJ; Eagling, VA; Tjia, JF | 1 |
| Kunze, KL; Racha, JK; Rettie, AE | 1 |
| Benet, LZ; Salphati, L | 1 |
| Hata, T; Iwasaki, K; Kaneko, H; Shiraga, T; Suzuki, A; Tozuka, Z | 1 |
| Huang, SL; Ou-Yang, DS; Wu, ZL; Xie, HG; Xu, ZH; Zhou, HH | 1 |
| Belpaire, FM; Pan, L | 1 |
| Kobayashi, S; Kumai, T; Tanaka, M; Tateishi, T; Watanabe, M | 1 |
| Butters, CJ; McKillop, D; Wild, MJ | 1 |
| de Groene, EM; Horbach, GJ; Kappers, WA; van Och, FM | 1 |
| Horsmans, Y; Spatzenegger, M; Verbeeck, RK | 1 |
| Anttila, M; Karnani, H; Nyman, L; Pelkonen, O; Salonen, JS; Taavitsainen, P | 1 |
| Kelly, JH; Sussman, NL | 1 |
| Bu, HZ; Knuth, K; Magis, L; Teitelbaum, P | 1 |
| Fay, LB; Guengerich, FP; Guillouzo, A; Huynh-Ba, T; Kerriguy, N; Langouët, S; Markovic, J; Turesky, RJ; Welti, DH | 1 |
| Arand, M; Friedberg, T; Härtter, S; Hiemke, C; Oesch, F; Wang, X; Weigmann, H | 1 |
| Guengerich, FP; Huynh-Ba, T; Langouët, S; Parisod, V; Turesky, RJ | 1 |
| Fernandez, M; Hashemi, E; Ioannides, C; Lewis, DF; Papagiannidou, E; Skene, DJ; Snelling, J | 1 |
| Boobis, AR; Edwards, RJ; Kappers, WA; Murray, S | 1 |
| Guillouzo, A; Kerriguy, N; Langouët, S; Paehler, A; Turesky, RJ; Welti, DH | 1 |
| Chen, CF; Chen, TL; Guengerich, FP; Jan, WC; Lin, LC; Ueng, YF | 1 |
| Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A | 1 |
| Guengerich, FP; Guillouzo, A; Langouët, S; Turesky, RJ | 1 |
| Audus, KL; Avery, ML; Meek, CE | 1 |
| Abolfathi, Z; Beaune, P; Labbé, L; Lessard, E; Pakdel, H; Turgeon, J | 1 |
| Hyland, R; Jones, BC; Smith, DA | 1 |
| Chiba, K; Kobayashi, K; Shimada, N; Urashima, K | 1 |
| Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI | 1 |
| Clay, CD; Dalton, TP; Genter, MB; Nebert, DW; Schneider, SN; Shertzer, HG | 1 |
| Chaudhary, A; Di Marco, A; Laufer, R; Marcucci, I; Taliani, M | 1 |
| Li, HD; Peng, WX; Zhou, HH | 1 |
| Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E | 1 |
| Gottesdiener, KM; Kari, PP; Marbury, T; Miller, JL; Mistry, GC; Rodrigues, AD; Simpson, RC; Wagner, JA; Winchell, GA | 1 |
| Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M | 1 |
| Chadwick, LR; Guo, J; Nikolic, D; Pauli, GF; van Breemen, RB | 1 |
| Miners, JO; Polasek, TM | 1 |
| Chapple, S; Collins, C; Fairman, DA | 1 |
| Akao, T; Hashimoto, Y; Ishida, K; Taguchi, M | 1 |
| Hsu, FF; Lakshmi, VM; Zenser, TV | 1 |
| Antonios, D; Gautier, JC; Lacour, S; Pallardy, M | 1 |
| He, YQ; Li, YY; Liu, Y; Lu, YL; Su, J; Tang, J; Wang, CH; Wang, ZT; Yang, L; Zhang, JW | 1 |
| Farid, NA; Hagihara, K; Ikeda, T; Ishizuka, T; Kazui, M; Kurihara, A; Nishiya, Y; Okazaki, O | 1 |
| Erve, JC; Vashishtha, SC; Wu, G | 1 |
| Chu, CC; Hsu, JT; Pan, KL; Yao, HT | 1 |
| Date, S; Emoto, C; Kashiyama, E; Kondo, S; Miyake, M; Nakazato, S; Umehara, K; Yoda, N | 1 |
| An, J; Hou, X; Li, M; Qiu, X; Yang, J | 1 |
| Adcock, JM; Daniels, JS; Locuson, CW; Williams, P | 1 |
| Camenisch, G; Chibale, K; Huth, F; Njuguna, NM; Schiller, H; Umehara, KI | 1 |
| Iwaki, M; Kawase, A; Komura, H; Nakamura, Y; Niwa, T | 1 |
| Reinen, J; Smit, M; Wenker, M | 1 |
| Cruz, A; González-Curbelo, MÁ; León, J; Murcia, H | 1 |
| Dai, Z; Ge, G; Hou, J; Sun, G; Sun, X; Xie, W; Yang, J; Yang, L; Zhou, P | 1 |
| Miura, T; Murayama, N; Shimizu, M; Suemizu, H; Uehara, S; Yamazaki, H | 1 |
2 review(s) available for theophylline and furafylline
| Article | Year |
|---|---|
Systemic exposure to dietary heterocyclic amines in man.
Topics: Animals; Biotransformation; Cattle; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Diet; Environmental Exposure; Enzyme Inhibitors; Hot Temperature; Humans; Imidazoles; Meat; Metabolic Clearance Rate; Mutagens; Quinoxalines; Theophylline | 1995 |
In vitro approaches to investigate mechanism-based inactivation of CYP enzymes.
Topics: Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Kinetics; Models, Biological; Oxidation-Reduction; Theophylline | 2007 |
2 trial(s) available for theophylline and furafylline
| Article | Year |
|---|---|
CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans.
Topics: Adult; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Imidazoles; Male; Oxidoreductases; Phenacetin; Quinoxalines; Theophylline | 1994 |
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline | 2005 |
73 other study(ies) available for theophylline and furafylline
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver.
Topics: Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diet; Humans; Hydroxylation; Mass Spectrometry; Microsomes, Liver; Mutagens; Oxidation-Reduction; Oxidoreductases; Quinoxalines; Theophylline | 1992 |
Exposure to, and activation of, the food derived mutagenic heterocyclic amine MeIQx.
Topics: Animals; Biotransformation; Cattle; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Female; Guinea Pigs; Hot Temperature; Humans; Intestinal Absorption; Isoenzymes; Male; Meat; Mesocricetus; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinoxalines; Rabbits; Salmonella typhimurium; Species Specificity; Theophylline | 1990 |
Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.
Topics: Adolescent; Adult; Animals; Cytochrome P-450 Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Theophylline | 1990 |
The influence of structure on the accumulation of caffeine induced by methyl xanthine derivatives.
Topics: Animals; Caffeine; Male; Rats; Rats, Inbred Strains; Theophylline; Xanthines | 1989 |
Some pharmacokinetic characteristics of furafylline, a new 1,3,8-trisubstituted xanthine.
Topics: Adult; Animals; Dogs; Drug Administration Schedule; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Theophylline | 1986 |
An animal model for the detection of drug-induced inhibition of caffeine metabolism.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Depression, Chemical; Drug Interactions; Ethanolamines; Female; Male; Models, Biological; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Theophylline | 1987 |
Accumulation of caffeine in healthy volunteers treated with furafylline.
Topics: Administration, Oral; Adult; Caffeine; Drug Interactions; Drug Tolerance; Female; Humans; Kinetics; Male; Sex Factors; Theophylline | 1987 |
Availability of furafylline.
Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Oxidoreductases; Theophylline | 1995 |
Direct characterization of the selectivity of furafylline as an inhibitor of human cytochromes P450 1A1 and 1A2.
Topics: Animals; Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Humans; Kinetics; Microsomes, Liver; Oxidoreductases; Theophylline | 1994 |
Characterization of the inhibition of P4501A2 by furafylline.
Topics: Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Microsomes, Liver; NADP; Oxidoreductases; Spectrophotometry, Ultraviolet; Theophylline | 1994 |
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.
Topics: Adult; Alkylation; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Male; Microsomes, Liver; Middle Aged; Oxazines; Oxidoreductases; Rats; Rats, Sprague-Dawley; Species Specificity; Substrate Specificity; Theophylline | 1994 |
Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1.
Topics: Adolescent; Adult; Aflatoxin B1; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxylation; Lymphocytes; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases; Theophylline; Troleandomycin | 1994 |
Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2.
Topics: Animals; Antibodies, Monoclonal; Benzoflavones; Cell Line; Cloning, Molecular; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Isoenzymes; Mice; Microsomes, Liver; Multigene Family; Oxidoreductases; Recombinant Proteins; Theophylline; Vaccinia virus | 1993 |
The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A.
Topics: Adrenergic beta-Agonists; Albuterol; Biomarkers; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Humans; Isoenzymes; Ketoconazole; Microsomes, Liver; Midazolam; Molecular Structure; Oxidation-Reduction; Quinidine; Recombinant Proteins; Salmeterol Xinafoate; Sulfaphenazole; Theophylline | 1996 |
Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19.
Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Humans; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Theophylline; Tranylcypromine; Warfarin | 1996 |
Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Kinetics; Liver; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Proton-Translocating ATPases; Rabbits; Rabeprazole; Recombinant Proteins; Sulfaphenazole; Theophylline | 1996 |
Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tolbutamide | 1996 |
The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations.
Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Enoxacin; Enzyme Induction; Etimizol; Glucuronidase; Glutathione; Liver; Male; Methylcholanthrene; Rats; Rats, Wistar; Tacrine; Theophylline | 1996 |
Inducibility of cytochromes P-450 by dioxin in liver and extrahepatic tissues of the marmoset monkey (Callithrix jacchus).
Topics: Animals; Callithrix; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dioxins; Gene Expression Regulation; Immunoblotting; Kidney; Kinetics; Lung; Microsomes, Liver; Oxidoreductases; Polychlorinated Dibenzodioxins; Theophylline | 1996 |
Assessing human risk to heterocyclic amines.
Topics: Animals; Chromatography, High Pressure Liquid; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Humans; Imidazoles; Meat; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinolines; Rabbits; Risk; Theophylline | 1997 |
Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes.
Topics: Adult; Aged; Anisoles; Anti-Infective Agents; Anticoagulants; Antifungal Agents; Antimalarials; Binding, Competitive; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Kinetics; Male; Methylation; Microsomes, Liver; Middle Aged; Quinidine; Substrate Specificity; Sulfaphenazole; Theophylline | 1997 |
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Inhibitors; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Wistar; Substrate Specificity; Sulfaphenazole; Testosterone; Theophylline; Tolbutamide | 1998 |
Mechanism-based inactivation of human cytochrome P450 1A2 by furafylline: detection of a 1:1 adduct to protein and evidence for the formation of a novel imidazomethide intermediate.
Topics: Cell Line, Transformed; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Deuterium; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Imidazoles; Microsomes, Liver; Oxygen; Theophylline; Xanthines | 1998 |
Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxigenin; Digoxin; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Models, Chemical; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Theophylline | 1999 |
Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes.
Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dibenzothiepins; Enzyme Inhibitors; Humans; Immune Sera; Isoenzymes; Ketoconazole; Microsomes, Liver; Oxidation-Reduction; Quinidine; Recombinant Proteins; Theophylline | 1999 |
Clomipramine N-demethylation metabolism in human liver microsomes.
Topics: Adult; Clomipramine; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; In Vitro Techniques; Mephenytoin; Methylation; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Theophylline; Troleandomycin | 1998 |
In vitro study on the involvement of CYP1A2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol.
Topics: Biotransformation; Child; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dopamine Antagonists; Enzyme Inhibitors; Haloperidol; Humans; Isoenzymes; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Theophylline | 1999 |
Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Inhibitors; Erythromycin; Half-Life; Haloperidol; Immune Sera; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Propionates; Quinine; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Theophylline; Troleandomycin | 1999 |
Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan.
Topics: Cimetidine; Clorgyline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Omeprazole; Oxazoles; Oxazolidinones; Recombinant Proteins; Serotonin Receptor Agonists; Theophylline; Tryptamines | 1999 |
Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons.
Topics: 3T3 Cells; Animals; Cell Line; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethyl Methanesulfonate; Fluorenes; Humans; Hypoxanthine Phosphoribosyltransferase; Ketoconazole; Lac Operon; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Polycyclic Aromatic Hydrocarbons; Pyrenes; Rats; Recombinant Fusion Proteins; Salmonella typhimurium; Theophylline | 2000 |
Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Intestine, Small; Ketoconazole; Liver; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; Theobromine; Theophylline | 2000 |
Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes.
Topics: Amphetamines; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Ketoconazole; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Selegiline; Theophylline | 2000 |
A fluorescent cell-based assay for cytochrome P-450 isozyme 1A2 induction and inhibition.
Topics: Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Evaluation, Preclinical; Enzyme Induction; Enzyme Inhibitors; Fluorescence; Humans; Methylcholanthrene; Oxazines; Theophylline | 2000 |
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction--tandem mass spectrometry method for CYP1A2 inhibition assessment.
Topics: Benzoflavones; Biological Assay; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Humans; Mass Spectrometry; Microsomes, Liver; Oxazines; Theophylline | 2001 |
Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2.
Topics: Animals; Biotransformation; Cell Separation; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; In Vitro Techniques; Inactivation, Metabolic; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Mutagens; Quinoxalines; Rats; Theophylline | 2001 |
Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin.
Topics: Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP1A2; Enzyme Inhibitors; Fluvoxamine; Humans; Melatonin; Microsomes, Liver; Serotonin; Theophylline | 2001 |
Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2.
Topics: Amines; Animals; Biotransformation; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; Inactivation, Metabolic; Kinetics; Microsomes, Liver; Mutagens; NADPH-Ferrihemoprotein Reductase; Quinoxalines; Rats; Recombinant Proteins; Species Specificity; Substrate Specificity; Theophylline | 2001 |
Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices.
Topics: Animals; Benzoflavones; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Melatonin; Microsomes, Liver; Models, Molecular; NADP; Oxidation-Reduction; Rats; Rats, Wistar; Theophylline | 2001 |
Diazinon is activated by CYP2C19 in human liver.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diazinon; Dose-Response Relationship, Drug; Humans; Insecticides; Ketoconazole; Liver; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Theophylline; Troleandomycin | 2001 |
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes.
Topics: Animals; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Hepatocytes; Humans; Imidazoles; Isoenzymes; Magnetic Resonance Spectroscopy; Rats; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Theophylline | 2002 |
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; In Vitro Techniques; Indole Alkaloids; Kinetics; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Plant Extracts; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Theophylline | 2002 |
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline | 2002 |
Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2.
Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Hepatocytes; Humans; Imidazoles; Liver; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Species Specificity; Theophylline | 2002 |
The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line.
Topics: Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Inhibitory Concentration 50; Methylcholanthrene; Microsomes, Liver; Smoking; Theophylline; Trophoblasts; Tumor Cells, Cultured | 2003 |
Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine.
Topics: Anti-Arrhythmia Agents; Benzoflavones; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Hydroxylation; Kinetics; Mexiletine; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Saccharomyces cerevisiae; Theophylline | 2003 |
Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Oxidation-Reduction; Pyrimidines; Quinidine; Sulfaphenazole; Theophylline; Triazoles; Voriconazole | 2003 |
Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat.
Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; DNA, Complementary; Enzyme Inhibitors; Gene Expression; Humans; Isoenzymes; Ketoconazole; Methoxsalen; Microsomes, Liver; Quinidine; Rats; Steroid 16-alpha-Hydroxylase; Steroid 21-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Sulfaphenazole; Theophylline | 2003 |
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline | 2003 |
Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dioxins; Ditiocarb; Electron Transport; Enzyme Induction; Enzyme Inhibitors; Hydrogen Peroxide; Mice; Mice, Knockout; Microsomes, Liver; NADP; Oxidative Stress; Reactive Oxygen Species; Theophylline | 2004 |
Development and validation of a high-throughput radiometric cyp2c9 inhibition assay using tritiated diclofenac.
Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Automation; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Humans; Hydroxylation; Microsomes, Liver; Radiometry; Reproducibility of Results; Theophylline; Tritium; Water | 2005 |
[Mechanism of mono-hydroxylation of daidzein in human liver microsomes].
Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Estrogens; Humans; Hydroxylation; Isoflavones; Microsomes, Liver; Theophylline | 2004 |
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes.
Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal | 2005 |
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene | 2005 |
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).
Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Dealkylation; Enzyme Inhibitors; Flavanones; Humans; Humulus; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Quercetin; Theophylline; Xanthones | 2006 |
Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?
Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dihydralazine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Models, Biological; NADP; Paroxetine; Pyrazines; Resveratrol; Stilbenes; Theophylline; Thiones; Thiophenes | 2007 |
Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in beta-naphthoflavone-treated Caco-2 cells.
Topics: Adrenergic beta-Antagonists; beta-Naphthoflavone; Caco-2 Cells; Carbazoles; Carvedilol; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Glucuronides; Humans; Microsomes; Oxidation-Reduction; Propanolamines; RNA, Messenger; Stereoisomerism; Theophylline | 2009 |
Identification of new 2-amino-3-methylimidazo[4,5-f]quinoline urinary metabolites from beta-naphthoflavone-treated mice.
Topics: Administration, Oral; Animals; beta-Naphthoflavone; Biotransformation; Carbon Radioisotopes; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dealkylation; Ellipticines; Enzyme Inhibitors; Female; Glucuronides; Injections, Intraperitoneal; Metabolomics; Mice; Mice, Inbred C57BL; Microsomes, Liver; Quinolines; Spectrometry, Mass, Electrospray Ionization; Sulfates; Sulfonic Acids; Tandem Mass Spectrometry; Theophylline | 2009 |
Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages.
Topics: Acetaminophen; Animals; Anthracenes; Cell Line; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Indomethacin; Interleukin-1beta; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mice; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction; Theophylline; Tumor Necrosis Factor-alpha | 2009 |
Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry.
Topics: Adult; Animals; Asian People; Autopsy; Cattle; Chalcones; China; Chlormethiazole; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dogs; Enzyme Inhibitors; Guinea Pigs; Humans; Hydroxylation; Ions; Kinetics; Male; Mice; Microsomes, Liver; Rats; Sheep; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Swine; Theophylline | 2009 |
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine | 2010 |
Characterization of glutathione conjugates of duloxetine by mass spectrometry and evaluation of in silico approaches to rationalize the site of conjugation for thiophene containing drugs.
Topics: Animals; Binding Sites; Cytosol; Drug Design; Duloxetine Hydrochloride; Glutathione; Glutathione Transferase; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Quinidine; Rationalization; Rats; Structure-Activity Relationship; Theophylline; Thiophenes | 2010 |
Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism.
Topics: Berberine; Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Humans; Recombinant Proteins; Theophylline | 2011 |
Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Inactivation, Metabolic; Inhibitory Concentration 50; Intestines; Isoenzymes; Kinetics; Liver; Macaca fascicularis; Male; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Reference Standards; RNA, Messenger; Substrate Specificity; Theophylline; Time Factors | 2012 |
Characterization of chicken cytochrome P450 1A4 and 1A5: inter-paralog comparisons of substrate preference and inhibitor selectivity.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Avian Proteins; Catalytic Domain; Chickens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Assays; Enzyme Inhibitors; Erythromycin; Escherichia coli; Oxazines; Piperonyl Butoxide; Protein Binding; Substrate Specificity; Theophylline | 2013 |
Evaluation of tizanidine as a marker of canine CYP1A2 activity.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzoflavones; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dogs; Enrofloxacin; Female; Fluoroquinolones; Microsomes, Liver; Molecular Probes; Phenacetin; Substrate Specificity; Theophylline | 2016 |
Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.
Topics: Acetates; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Ketoconazole; Phenotype; Quinidine; Quinolines; Sulfaphenazole; Sulfides; Theophylline; Ticlopidine | 2016 |
Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carbazoles; Carvedilol; Catalysis; Cells, Cultured; Cytochrome P-450 CYP3A; Humans; Insecta; Isoenzymes; Male; Microsomes, Liver; Oxidation-Reduction; Propanolamines; Quinine; Rats; Rats, Sprague-Dawley; Stereoisomerism; Theophylline | 2018 |
Evaluation of Strategies for the Assessment of Drug-Drug Interactions Involving Cytochrome P450 Enzymes.
Topics: Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dihydralazine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Microsomes, Liver; Mifepristone; Paroxetine; Theophylline; Troleandomycin; Verapamil | 2018 |
Study on the inhibitory effect of furafylline and troleandomycin in the 7-methoxyresorufin-O-demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescen
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Microsomes, Liver; Nifedipine; Oxazines; Poultry; Theophylline; Troleandomycin | 2019 |
Interspecies Variation in NCMN
Topics: Animals; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Demethylation; Dogs; Fluorescent Dyes; Humans; Isoquinolines; Kinetics; Macaca fascicularis; Mice; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Species Specificity; Swine; Swine, Miniature; Theophylline | 2019 |
Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice.
Topics: Animals; Coumarins; Cytochrome P-450 CYP1A2; Hepatocytes; Humans; Mice; Microsomes, Liver; Theophylline | 2021 |