theophylline and enprofylline

theophylline has been researched along with enprofylline in 128 studies

Research

Studies (128)

Timeframe	Studies, this research(%)	All Research%
pre-1990	71 (55.47)	18.7374
1990's	42 (32.81)	18.2507
2000's	11 (8.59)	29.6817
2010's	3 (2.34)	24.3611
2020's	1 (0.78)	2.80

Authors

Authors	Studies
Hasegawa, T; Iwasaki, N; Kakiuchi, M; Kato, H; Konno, K; Miyamoto, K; Sakai, R; Sanae, F; Takagi, K; Yamamoto, Y	1
Bridson, PK; Daly, JW; Hide, I	1
Daly, JW; Padgett, WL; Shamim, MT; Ukena, D	1
Daly, JW; Manning, M; Müller, CE; Shi, D	1
Hasegawa, T; Iwasaki, N; Konno, K; Kurita, M; Miyamoto, K; Ohshima, T; Sakai, R; Sanae, F; Takagi, K; Yamamoto, Y	1
Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE	1
Daly, JW; Diekmann, M; Jacobson, KA; Müller, CE; Padgett, WL; Qurishi, R; Thorand, M	1
Elzein, E; Gimbel, A; Kalla, RV; Li, X; Maa, T; Palle, V; Perry, T; Varkhedkar, V; Zablocki, J; Zeng, D	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Bertarelli, DC; Borrmann, T; Florin, NC; Hinz, S; Li, W; Müller, CE; Scheiff, AB	1
Azuaje, J; Carbajales, C; Crespo, A; El Maatougui, A; Escalante, L; García-Mera, X; González-Gómez, M; Gutiérrez-de-Terán, H; Miguez, G; Sotelo, E	1
Barawkar, DA; Basu, S; Bedse, G; Bonagiri, R; Chaturvedi, S; Chugh, A; Dusange, S; Ghosh, I; Goswami, A; Gundu, J; Jadhav, D; Karande, V; Kulkarni, A; Kumar, S; Menon, S; Mookhtiar, KA; Mukhopadhyay, P; Paliwal, S; Palle, VP; Panmand, A; Patel, M; Prasad, V; Quraishi, A; Ramdas, V; Reddy, BS; Rouduri, S; Thakre, R; Thorat, S; Waman, Y	1
Gaba, S; Gupta, GD; Monga, V; Patel, R; Saini, A; Singh, G	1
Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S	1
Erjefält, I; Persson, CG	3
Barlinski, J; Frossard, N; Lockhart, A	1
Misso, NL; Thompson, PJ	1
Forsberg, K; Karlsson, JA; Persson, CG; Zackrisson, C	1
Howell, RE; Kinnier, WJ; Muehsam, WT	1
Aas, P; Walday, P	1
Dulloo, AG; Girardier, L; Seydoux, J	1
Furui, H; Kaneko, M; Satake, T; Suzuki, K; Takagi, K	1
Brockway, M; Fagan, D; Lamont, M; Scott, DB; Tiplady, B	1
Dragunow, M	1
Arnold, JD; Courtenay-Evans, RJ; Higgins, AJ; O'Reilly, JF; Petrie, GR; Swift, CG; Whitfield, R	1
Lenders, JW; Smits, P; Thien, T	1
Dar, MS	1
Amundsen, T; Brenna, E; Eriksson, G; Holte, S; Källén, AG; Naustdal, T; Persson, CG; Storstein, L; Syvertsen, U; Vilsvik, JS	1
Bergamaschi, M; Bongrani, S; Papotti, M; Pastore, F; Razzetti, R	1
Karlsson, JA; Kröll, F; Nilsson, E; Persson, CG; Ryrfeldt, A	1
Brackett, LE; Daly, JW; Shamim, MT	1
Abboud, RT; Boucher, S; Chapman, KR; Day, A; Hodder, RV; Hyland, RH; Kreisman, H; Peters, S; Rivington, R; York, EL	1
Finney, MJ; Karlsson, JA; Persson, CG	1
Crowley, JJ; Cusack, BJ; Nielson, CP; Vestal, RE	1
Conradson, TB; Eklundh, G; Olofsson, B; Pahlm, O; Persson, G	2
Napier, FE; Temple, DM	3
Belloni, FL; Gerritsen, ME; Liang, BC	1
Clarke, H; Cushley, MJ; Holgate, ST; Persson, CG	1
Boorsma, M; Jonkman, JH; Koëter, GH; Kraan, J; van der Mark, TW	1
Borgå, O; Krohn, L; Laursen, LC; Weeke, B	1
Baxter, GS; Collis, MG; Keddie, JR	1
Edvinsson, L; Sjögren, A	1
Bowmer, CJ; Collis, MG; Kellett, R; Yates, MS	1
Barnes, PJ; Chung, KF	1
Bodman, S; Gilner, D; Nelson, HS; Patel, A; Winder, J; Zunich, KM	1
Jourdan, ML; Lee, TF; Wang, LC	1
Karlsson, JA; Kröll, F; Persson, CG; Ryrfeldt, A	1
Bergman, B; Fredholm, BB; Lindström, K	1
Schirren, CG; Schwabe, U; Ukena, D	1
Andersson, KE; Kjellin, G; Persson, CG	1
Fredholm, BB; Jonzon, B; Lindström, K	1
Gustafsson, B; Persson, CG	1
Askholt, J; Nielsen-Kudsk, JE	1
de Jong, PE; de Zeeuw, RA; Ekman, I; Gips, CH; Jonkman, JH; Koëter, GH; Kraan, J; van der Mark, TW	1
Borgström, L; de Noord, OE; Jonkman, JH; Koëter, GH; Kraan, J; Laseur, M	1
Laursen, LC	1
Arlock, P	1
Aber, V; Barnes, PJ; Conradson, TB; Dixon, CM; Fuller, RW; Hughes, JM; Maxwell, DL	1
Abbracchio, MP; Cattabeni, F	1
Andersson, RG; Berg, G; Ryden, G	1
Eriksson, G; Haahtela, T; Venho, K	1
Eriksson, G; Laursen, LC; Weeke, B	1
Boe, J; Eriksson, G; Ljungholm, K	1
Aubier, M; Mal, H; Murciano, D; Pariente, R; Viirès, N	1
Kluge, TB; Oellerich, M; Schumann, G; Sybrecht, GW	1
Conradson, TB	2
Broadley, KJ; Darmani, NA	1
Karlsson, JA; Nielsen-Kudsk, JE; Persson, CG	1
Grgurinovich, N	1
Edvinsson, L; Fletcher, R; Monti, M; Ranklev, E	1
Hedner, J; Hedner, T; Holmgren, M; Mellstrand, T; Nordberg, G	1
Johannesson, N; Laursen, LC; Weeke, B	3
Burns, RJ; Esquivel, M; Ogilvie, RI	1
Andersson, KE; Joelsson, B; Johannesson, N; Persson, CG	1
Nielsen-Kudsk, JE	1
Johannesson, N; Pauwels, R; Persson, CG; Van der Straeten, M; Van Renterghem, D	1
Fredholm, BB; Jonzon, B	1
Hedner, J; Hedner, T; Jonason, J; Persson, B; Wessberg, P	1
Pauwels, R	1
Edvinsson, L; Fredholm, BB	1
Edholm, LE; Erjefält, I; Karlsson, JA; Lamm, CJ; Persson, CG	1
Andersson, RG; Toll, JB	1
Erjefält, I; Karlsson, JA; Persson, CG	2
Andersson, KE; Lunell, E; Persson, CG; Svedmyr, N	1
Andersson, KE; Persson, CG; Vinge, E	1
Fagerström, PO; Johannesson, N; Laursen, LC; Weeke, B	1
Persson, CG	1
Andersson, KE; Johannesson, N; Karlberg, B; Persson, CG	1
Borgå, O; Svensson, I; Tegnér, K	1
Johannesson, N; Laursen, LC; Søndergaard, I; Weeke, B	2
Andersson, RG; Hedman, SE	1
Armstrong, EL; Baer, PG; Cagen, LM	1
Kjellin, G; Persson, CG	1
Schudt, C; Sybrecht, GW; Ukena, D	1
Cortijo, J; Morcillo, EJ; Orón, JD; Perpiñá, M	1
Chapman, KR; Kallen, A; Ljungholm, K	1
Alkner, U; Persson, CG; Pipkorn, U; Svensson, C	1
Chapman, KR; David-Wang, AS; Freeman, D; Scarth, B	1
Joran, ME; Murphy, DJ; Renninger, JE	1
Avital, A; Chernick, V; Jansen, AH; Sitar, DS	1
Conradsson, T; Edlund, A; Sollevi, A	1
Breschi, MC; Lazzeri, N; Martinotti, E; Nieri, P; Scatizzi, R	1
Bredenbröker, D; Fehmann, HC; Schudt, C; Schwarz, F; Von Wichert, P; Wagner, U	1
De Sarro, A; De Sarro, G; Grasso, S; Nava, F; Zappala, M	1
Hasegawa, T; Kuzuya, T; Nabeshima, T; Shiraki, R	1
Goshgarian, HG; Nantwi, KD	2
Persson, C	1
Aubier, M; Boczkowski, J; Danialou, G; Vicaut, E	1
Fozard, JR; Hannon, JP	1
Figler, H; Jin, X; Linden, J; Robeva, AS; Thai, T	1
Hasegawa, T; Itoh, A; Mamiya, T; Nabeshima, T; Nakayama, S; Noda, Y; Shiotani, T	1
Biaggioni, I; Feoktistov, I	1
Breschi, MC; Calderone, V; Martinotti, E; Nieri, P	1
Kondo, Y; Morishima, T; Tsuge, M; Wada, T; Yashiro, M; Yasui, K	1
Barnes, PJ; Calzetta, L; Cazzola, M; Criner, GJ; Gabriella Matera, M; Martinez, FJ; Papi, A	1

Reviews

8 review(s) available for theophylline and enprofylline

Article	Year
Adenosine receptor antagonists: Recent advances and therapeutic perspective. European journal of medicinal chemistry, 2022, Jan-05, Volume: 227 Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Structure-Activity Relationship	2022
Respiratory and allergic disease. I. British medical journal (Clinical research ed.), 1988, Jan-02, Volume: 296, Issue:6614 Topics: Asthma; Bronchodilator Agents; Delayed-Action Preparations; Histamine H1 Antagonists; Humans; Nedocromil; Quinolines; Rhinitis, Allergic, Seasonal; Theophylline; Xanthines	1988
Effects of enprofylline and theophylline may show the role of adenosine. Life sciences, 1986, Mar-24, Volume: 38, Issue:12 Topics: Adenosine; Animals; Asthma; Brain; Bronchodilator Agents; Caffeine; Diuresis; Fatty Acids, Nonesterified; Gastric Acid; Heart; Humans; Kidney; Kinetics; Lung; Natriuresis; Phosphodiesterase Inhibitors; Receptors, Cell Surface; Receptors, Purinergic; Respiration; Seizures; SRS-A; Theophylline; Vasoconstriction; Vasodilation; Xanthines	1986
Anti asthmatic effects and pharmacokinetics of enprofylline--a new xanthine derivate. Danish medical bulletin, 1987, Volume: 34, Issue:6 Topics: Administration, Oral; Asthma; Bronchi; Female; Humans; Infusions, Intravenous; Male; Theophylline; Xanthines	1987
[Animal experiments and clinical studies on the role of adenosine in bronchial asthma]. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1984, Volume: 46, Issue:6 Topics: Adenosine; Adult; Animals; Asthma; Atropine; Basophils; Bronchi; Bronchodilator Agents; Cromolyn Sodium; Double-Blind Method; Female; Hexamethonium Compounds; Humans; Inosine; Lung; Male; Mast Cells; Random Allocation; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Urethane; Vagotomy; Xanthines	1984
The profile of action of enprofylline, or why adenosine antagonism seems less desirable with xanthine antiasthmatics. Agents and actions. Supplements, 1983, Volume: 13 Topics: Adenosine; Animals; Asthma; Bronchi; Cats; Central Nervous System; Chemical Phenomena; Chemistry; Diuresis; Guinea Pigs; Heart; Humans; Lung; Mice; Nausea; Rats; Structure-Activity Relationship; Theophylline; Xanthines	1983
Adenosine receptor ligands: potential as therapeutic agents in asthma and COPD. Pulmonary pharmacology & therapeutics, 1999, Volume: 12, Issue:2 Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Humans; Ligands; Lung Diseases, Obstructive; Receptors, Purinergic P1; Theophylline; Xanthines	1999
Efficacy and safety profile of xanthines in COPD: a network meta-analysis. European respiratory review : an official journal of the European Respiratory Society, 2018, Jun-30, Volume: 27, Issue:148 Topics: Bronchodilator Agents; Forced Expiratory Volume; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Recovery of Function; Theophylline; Treatment Outcome; Xanthines	2018

Trials

29 trial(s) available for theophylline and enprofylline

Article	Year
A comparison of the CNS effects of enprofylline and theophylline in healthy subjects assessed by performance testing and subjective measures. British journal of clinical pharmacology, 1990, Volume: 30, Issue:1 Topics: Acoustic Stimulation; Adolescent; Adult; Attention; Central Nervous System; Central Nervous System Stimulants; Double-Blind Method; Flicker Fusion; Humans; Infusions, Intravenous; Male; Photic Stimulation; Psychomotor Performance; Reaction Time; Theophylline; Xanthines	1990
Comparative assessment of enprofylline and theophylline for chronic obstructive airways disease in the elderly. Respiratory medicine, 1990, Volume: 84, Issue:3 Topics: Aged; Bronchodilator Agents; Double-Blind Method; Female; Headache; Humans; Lung Diseases, Obstructive; Male; Peak Expiratory Flow Rate; Theophylline; Xanthines	1990
Comparison between theophylline and an adenosine non-blocking xanthine in acute asthma. The European respiratory journal, 1990, Volume: 3, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Asthma; Bronchodilator Agents; Double-Blind Method; Drug Evaluation; Female; Heart Rate; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Random Allocation; Theophylline; Xanthines	1990
A comparison of enprofylline and theophylline in the maintenance therapy of chronic reversible obstructive airway disease. The Journal of allergy and clinical immunology, 1990, Volume: 85, Issue:2 Topics: Adolescent; Adult; Aged; Bronchodilator Agents; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Multicenter Studies as Topic; Peak Expiratory Flow Rate; Randomized Controlled Trials as Topic; Theophylline; Time Factors; Xanthines	1990
Arrhythmogenicity from combined bronchodilator therapy in patients with obstructive lung disease and concomitant ischemic heart disease. Chest, 1987, Volume: 91, Issue:1 Topics: Aged; Asthma; Bronchitis; Cardiac Complexes, Premature; Clinical Trials as Topic; Coronary Disease; Female; Heart Rate; Humans; Male; Middle Aged; Random Allocation; Theophylline; Xanthines	1987
The protective effects of intravenous theophylline and enprofylline against histamine- and adenosine 5'-monophosphate-provoked bronchoconstriction: implications for the mechanisms of action of xanthine derivatives in asthma. Pulmonary pharmacology, 1989, Volume: 2, Issue:3 Topics: Adult; Allergens; Asthma; Bronchoconstriction; Bronchodilator Agents; Cyclic AMP; Female; Forced Expiratory Volume; Heart Rate; Histamine Antagonists; Humans; Infusions, Intravenous; Male; Skin Tests; Theophylline; Xanthines	1989
Effect of theophylline and enprofylline on bronchial hyperresponsiveness. Thorax, 1989, Volume: 44, Issue:12 Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Double-Blind Method; Drug Administration Schedule; Forced Expiratory Volume; Humans; Injections, Intravenous; Male; Methacholine Chloride; Methacholine Compounds; Theophylline; Xanthine; Xanthines	1989
Cardiac arrhythmias in patients with mild-to-moderate obstructive lung disease. Comparison of beta-agonist therapy alone and in combination with a xanthine derivative, enprofylline or theophylline. Chest, 1985, Volume: 88, Issue:4 Topics: Adrenergic beta-Agonists; Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Random Allocation; Respiratory Function Tests; Theophylline; Xanthines	1985
The effect of theophylline and enprofylline on the late cutaneous response to antigen and compound 48/80. The Journal of allergy and clinical immunology, 1989, Volume: 83, Issue:2 Pt 1 Topics: Adult; Antigens; Dermatitis, Contact; Double-Blind Method; Humans; Hypersensitivity, Immediate; p-Methoxy-N-methylphenethylamine; Skin Tests; Theophylline; Xanthines	1989
Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man. Acta physiologica Scandinavica, 1987, Volume: 131, Issue:3 Topics: Adenosine; Adult; Blood Gas Monitoring, Transcutaneous; Dose-Response Relationship, Drug; Heart Rate; Humans; Male; Respiration; Theophylline; Xanthines	1987
Comparison of enprofylline and theophylline for intravenous treatment of acute asthma. Allergy, 1986, Volume: 41, Issue:2 Topics: Acute Disease; Adult; Aged; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Theophylline; Xanthines	1986
Enprofylline and theophylline slow-eroding tablets in the treatment of asthma: a comparison. Respiration; international review of thoracic diseases, 1986, Volume: 50, Issue:1 Topics: Adult; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Headache; Humans; Middle Aged; Peak Expiratory Flow Rate; Theophylline; Xanthines	1986
Efficacy of enprofylline, a new bronchodilating xanthine, in acute asthma. Annals of allergy, 1987, Volume: 59, Issue:2 Topics: Adult; Aged; Asthma; Blood Pressure; Bronchodilator Agents; Female; Heart Rate; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Status Asthmaticus; Theophylline; Xanthines	1987
Effects of theophylline and enprofylline on diaphragmatic contractility. Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 63, Issue:1 Topics: Adult; Bronchodilator Agents; Diaphragm; Humans; Kinetics; Male; Muscle Contraction; Muscles; Theophylline; Xanthines	1987
Enprofylline: pharmacokinetics and comparison with theophylline of acute effects on bronchial reactivity in normal subjects. European journal of clinical pharmacology, 1986, Volume: 30, Issue:1 Topics: Adult; Blood Proteins; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Chromatography, High Pressure Liquid; Female; Histamine; Humans; Kinetics; Male; Spectrophotometry, Ultraviolet; Theophylline; Xanthines	1986
Effects of enprofylline and theophylline on exercise-induced asthma. Allergy, 1985, Volume: 40, Issue:7 Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Nausea; Peak Expiratory Flow Rate; Theophylline; Xanthines	1985
Cardiovascular effects of enprofylline and theophylline. Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:4 Topics: Adult; Blood Pressure; Chromatography, High Pressure Liquid; Epinephrine; Heart Rate; Humans; Infusions, Parenteral; Male; Norepinephrine; Physical Exertion; Plethysmography; Random Allocation; Theophylline; Vascular Resistance; Xanthines	1986
The effect of theophylline and enprofylline on allergen-induced bronchoconstriction. The Journal of allergy and clinical immunology, 1985, Volume: 76, Issue:4 Topics: Adult; Allergens; Bronchial Spasm; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Infusions, Parenteral; Male; Pulmonary Ventilation; Theophylline; Xanthines	1985
Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease. European journal of clinical pharmacology, 1982, Volume: 22, Issue:5 Topics: Adult; Aged; Clinical Trials as Topic; Female; Forced Expiratory Volume; Hemodynamics; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Receptors, Cell Surface; Receptors, Purinergic; Spirometry; Theophylline; Tremor; Vital Capacity; Xanthines	1982
Intravenous administration of enprofylline to asthmatic patients. European journal of clinical pharmacology, 1983, Volume: 24, Issue:3 Topics: Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Spirometry; Theophylline; Xanthines	1983
Increase in plasma free fatty acids and natriuresis by xanthines may reflect adenosine antagonism. European journal of clinical pharmacology, 1984, Volume: 26, Issue:1 Topics: Adenosine; Adult; Blood Glucose; Catecholamines; Diuresis; Fatty Acids, Nonesterified; Glucagon; Hemodynamics; Humans; Insulin; Male; Middle Aged; Natriuresis; Renin; Theophylline; Xanthines	1984
Continuous treatment of asthmatic patients with enprofylline and theophylline. European journal of respiratory diseases, 1984, Volume: 65, Issue:7 Topics: Adult; Aged; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Random Allocation; Theophylline; Xanthines	1984
Maximally effective plasma concentrations of enprofylline and theophylline during constant infusion. British journal of clinical pharmacology, 1984, Volume: 18, Issue:4 Topics: Adult; Aged; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Infusions, Parenteral; Male; Middle Aged; Spirometry; Theophylline; Tremor; Xanthines	1984
Comparison of oral enprofylline and theophylline in asthmatic patients. European journal of clinical pharmacology, 1984, Volume: 26, Issue:6 Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Female; Humans; Male; Middle Aged; Spirometry; Theophylline; Xanthines	1984
Cardiovascular effects of two different xanthines in healthy subjects. Studies at rest, during exercise and in combination with a beta-agonist, terbutaline. European journal of clinical pharmacology, 1984, Volume: 27, Issue:3 Topics: Adult; Blood Pressure; Bronchodilator Agents; Heart Rate; Hemodynamics; Humans; Male; Physical Exertion; Posture; Rest; Terbutaline; Theophylline; Xanthines	1984
Long-term xanthine therapy of asthma. Enprofylline and theophylline compared. International Enprofylline Study Group. Chest, 1994, Volume: 106, Issue:5 Topics: Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Statistics, Nonparametric; Theophylline; Time Factors; Treatment Outcome; Xanthines	1994
Histamine-induced airway mucosal exudation of bulk plasma and plasma-derived mediators is not inhibited by intravenous bronchodilators. European journal of clinical pharmacology, 1994, Volume: 46, Issue:1 Topics: Adolescent; Adult; Albumins; Blood Proteins; Bradykinin; Bronchodilator Agents; Capillary Permeability; Double-Blind Method; Exudates and Transudates; Female; Fibrinogen; Histamine; Humans; Injections, Intravenous; Male; Mucous Membrane; Nasal Lavage Fluid; Terbutaline; Theophylline; Xanthines	1994
A rapid monoclonal antibody blood theophylline assay; lack of cross-reactivity with enprofylline. Therapeutic drug monitoring, 1994, Volume: 16, Issue:3 Topics: Adult; Antibodies, Monoclonal; Antibody Specificity; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cross Reactions; Double-Blind Method; Humans; Immunoassay; Theophylline; Xanthines	1994
A role for adenosine in coronary vasoregulation in man. Effects of theophylline and enprofylline. Clinical physiology (Oxford, England), 1995, Volume: 15, Issue:6 Topics: Adenosine; Adult; Blood Pressure; Coronary Circulation; Double-Blind Method; Exercise; Female; Heart; Heart Rate; Humans; Male; Myocardium; Oxygen Consumption; Purinergic P1 Receptor Antagonists; Theophylline; Vascular Resistance; Vasodilator Agents; Xanthines	1995

Other Studies

91 other study(ies) available for theophylline and enprofylline

Article	Year
Effects of alkyl substitutions of xanthine skeleton on bronchodilation. Journal of medicinal chemistry, 1992, Oct-30, Volume: 35, Issue:22 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Animals; Bronchodilator Agents; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Organ Specificity; Receptors, Purinergic; Structure-Activity Relationship; Trachea; Xanthines	1992
Imidazodiazepinediones: a new class of adenosine receptor antagonists. Journal of medicinal chemistry, 1990, Volume: 33, Issue:10 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Azepines; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Imidazoles; In Vitro Techniques; Molecular Conformation; Phenylisopropyladenosine; Rats; Receptors, Purinergic; Structure-Activity Relationship	1990
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines	1989
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Animals; Brain; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theophylline; Xanthines	1993
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. Journal of medicinal chemistry, 1993, May-14, Volume: 36, Issue:10 Topics: Administration, Oral; Animals; Bronchial Spasm; Bronchodilator Agents; Guinea Pigs; Heart Rate; Male; Mice; Muscle Relaxation; Structure-Activity Relationship; Trachea; Xanthines	1993
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11 Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines	2002
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. Journal of medicinal chemistry, 2002, Aug-01, Volume: 45, Issue:16 Topics: 3T3 Cells; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Electrophoresis, Capillary; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; In Vitro Techniques; Membranes; Mice; PC12 Cells; Purinergic P1 Receptor Antagonists; Purines; Purinones; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Solubility; Stereoisomerism; Structure-Activity Relationship; Water	2002
Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists. Journal of medicinal chemistry, 2006, Jun-15, Volume: 49, Issue:12 Topics: Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Humans; Pyrazoles; Radioligand Assay; Theophylline; Xanthines	2006
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13 Topics: Adenosine A2 Receptor Antagonists; Animals; Drug Design; Humans; Kinetics; Ligands; Mice; Protein Binding; Radioligand Assay; Rats; Receptor, Adenosine A2B; Xanthines	2009
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. Journal of medicinal chemistry, 2016, Mar-10, Volume: 59, Issue:5 Topics: Adenosine A2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Pyrimidinones; Receptor, Adenosine A2B; Structure-Activity Relationship	2016
A European journal of medicinal chemistry, 2017, Feb-15, Volume: 127 Topics: Adenosine A2 Receptor Antagonists; Animals; Brain; Chemistry Techniques, Synthetic; Drug Design; Male; Mice; Receptor, Adenosine A2B; Structure-Activity Relationship; Xanthine	2017
Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study. European journal of pharmacology, 1992, Nov-03, Volume: 222, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Caffeine; Electroencephalography; Male; Parasympatholytics; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Theophylline; Xanthines	1992
Increased sensitivity to toluene diisocyanate (TDI) in airways previously exposed to low doses of TDI. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1992, Volume: 22, Issue:9 Topics: Administration, Cutaneous; Administration, Topical; Animals; Budesonide; Guinea Pigs; Inflammation; Intubation, Intratracheal; Male; Pregnenediones; Respiratory Hypersensitivity; Theophylline; Toluene 2,4-Diisocyanate; Xanthines	1992
Modulation by theophylline and enprofylline of the excitatory non-cholinergic transmission in guinea-pig bronchi. The European respiratory journal, 1992, Volume: 5, Issue:10 Topics: Airway Resistance; Animals; Bronchi; Bronchodilator Agents; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Nerve Fibers; Neuropeptides; Theophylline; Xanthines	1992
Xanthines inhibit human platelet aggregation induced by platelet-activating factor. Clinical and experimental pharmacology & physiology, 1992, Volume: 19, Issue:8 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Theophylline; Xanthines	1992
Selective inhibition of cough and bronchoconstriction in conscious guinea pigs. Respiration; international review of thoracic diseases, 1992, Volume: 59, Issue:2 Topics: Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Citrates; Citric Acid; Cough; Female; Guinea Pigs; Ipratropium; Lidocaine; Male; Terbutaline; Theophylline; Xanthines	1992
Mechanism for the emetic side effect of xanthine bronchodilators. Life sciences, 1990, Volume: 46, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Ferrets; Male; Nausea; Phosphodiesterase Inhibitors; Theophylline; Vomiting; Xanthines	1990
Prejunctional stimulation of cholinergic nerves in rat airway smooth muscle by an adenosine analogue. Pulmonary pharmacology, 1991, Volume: 4, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cholinergic Fibers; In Vitro Techniques; Male; Neuromuscular Junction; Phenethylamines; Rats; Rats, Inbred Strains; Theophylline; Xanthines	1991
Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue. International journal of obesity, 1991, Volume: 15, Issue:5 Topics: 2-Chloroadenosine; Adenosine; Adenosine Deaminase; Adipose Tissue, Brown; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature Regulation; Caffeine; Culture Techniques; Dose-Response Relationship, Drug; Drug Synergism; Ephedrine; Male; Oxygen Consumption; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Theophylline; Xanthines	1991
Pharmacologic control of plasma exudation into tracheobronchial airways. The American review of respiratory disease, 1991, Volume: 143, Issue:5 Pt 1 Topics: Animals; Asthma; Bronchi; Bronchodilator Agents; Capillary Permeability; Cromolyn Sodium; Guinea Pigs; Lidocaine; Male; Plasma; Terbutaline; Theophylline; Trachea; Xanthines	1991
Comparison of theophylline and enprofylline effects on human neutrophil superoxide production. Clinical and experimental pharmacology & physiology, 1990, Volume: 17, Issue:12 Topics: Adenosine; Adenosine Deaminase; Adult; Anti-Inflammatory Agents, Non-Steroidal; Bronchodilator Agents; Chromatography, High Pressure Liquid; Drug Interactions; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Theophylline; Xanthines	1990
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4 Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines	1990
Caffeine and theophylline attenuate adenosine-induced vasodilation in humans. Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:4 Topics: Adenosine; Adolescent; Adult; Bronchodilator Agents; Caffeine; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Regional Blood Flow; Theophylline; Vasodilation; Xanthines	1990
Central adenosinergic system involvement in ethanol-induced motor incoordination in mice. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3 Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Brain; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Motor Activity; Phenylisopropyladenosine; Psychomotor Performance; Receptors, Purinergic; Theophylline; Time Factors; Tissue Distribution; Tritium; Xanthines	1990
Lack of cardiostimulant effects of bamifylline in in vitro and in vivo models. Arzneimittel-Forschung, 1990, Volume: 40, Issue:2 Pt 1 Topics: Animals; Cardiotonic Agents; Electrocardiography; Guinea Pigs; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Rabbits; Rats; Reserpine; Species Specificity; Theophylline; Xanthines	1990
Rapid clearance of xanthines from airway and pulmonary tissues. The American review of respiratory disease, 1990, Volume: 141, Issue:5 Pt 1 Topics: Animals; Biotransformation; Bronchi; Bronchodilator Agents; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Extracellular Space; Guinea Pigs; Lung; Male; Perfusion; Sucrose; Theophylline; Trachea; Tritium; Xanthines	1990
Activities of caffeine, theophylline, and enprofylline analogs as tracheal relaxants. Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Receptors, Purinergic; Theophylline; Trachea; Xanthines	1990
Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. British journal of pharmacology, 1985, Volume: 85, Issue:1 Topics: Adenosine; Adenosine Triphosphate; Bronchi; Bronchodilator Agents; Carbachol; Histamine; Humans; In Vitro Techniques; Lung; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Prostaglandin D2; Prostaglandins D; Substance P; Terbutaline; Theophylline; Xanthines	1985
Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation. The Journal of allergy and clinical immunology, 1986, Volume: 78, Issue:4 Pt 1 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adult; Bucladesine; Calcimycin; Calcium; Catecholamines; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isoproterenol; Middle Aged; Neutrophils; Prostaglandins E; Theophylline; Xanthines	1986
The relation between effects of adenosine, theophylline and enprofylline on the contractility of sensitized guinea-pig lung strips. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:6 Topics: Adenosine; Animals; Antigens; Bronchodilator Agents; Dipyridamole; Female; Guinea Pigs; Histamine Release; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Respiratory Muscles; SRS-A; Theophylline; Xanthines	1987
Effects of alkylxanthines and calcium antagonists on adenosine uptake by cultured rabbit coronary microvascular endothelium. Pharmacology, 1987, Volume: 35, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium Channel Blockers; Cells, Cultured; Coronary Vessels; Dipyridamole; Endothelium; Ethanol; Isoproterenol; Male; Microcirculation; Rabbits; Theophylline; Trifluoperazine; Xanthines	1987
Theophylline's inhibition of antigen-induced contraction of human parenchymal strips is independent of adenosine antagonism. European journal of pharmacology, 1987, Oct-13, Volume: 142, Issue:2 Topics: Adenosine; Airway Resistance; Antigens; Bronchodilator Agents; Histamine Release; Humans; In Vitro Techniques; Lung; Respiratory Hypersensitivity; Theophylline; Xanthines	1987
Distribution of enprofylline and theophylline between plasma and cerebrospinal fluid. Therapeutic drug monitoring, 1989, Volume: 11, Issue:2 Topics: Adult; Female; Half-Life; Humans; Male; Middle Aged; Theophylline; Xanthines	1989
The influence of xanthines on the contractile responses of PGF2 alpha and PGD2 in human parenchymal strips. Prostaglandins, 1989, Volume: 38, Issue:2 Topics: Bronchodilator Agents; Dinoprost; Histamine; Humans; Lung; Muscle Contraction; Muscle, Smooth; Prostaglandin D2; Theophylline; Xanthines	1989
The adenosine receptor antagonist, 8-phenyltheophylline, causes diuresis and saliuresis in the rat. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:11 Topics: Adenosine; Animals; Diuresis; Heart Rate; Rats; Rats, Inbred Strains; Receptors, Purinergic; Salts; Theophylline; Xanthines	1986
Direct vasomotor effects of theophylline and enprofylline on human coronary artery in-vitro: comparison with feline coronary and cerebral arteries. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:7 Topics: Animals; Cats; Cerebral Arteries; Coronary Vessels; Dinoprost; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Middle Aged; Prostaglandins F; Theophylline; Vasoconstriction; Xanthines	1987
Effect of 8-phenyltheophylline, enprofylline and hydrochlorothiazide on glycerol-induced acute renal failure in the rat. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:10 Topics: Acute Kidney Injury; Animals; Bronchodilator Agents; Creatinine; Glycerol; Hydrochlorothiazide; Inulin; Kidney; Male; Organ Size; Rats; Rats, Inbred Strains; Theophylline; Urea; Xanthines	1987
Mechanisms underlying the supra-maximal thermogenesis elicited by aminophylline in rats. Life sciences, 1989, Volume: 44, Issue:14 Topics: Adenosine; Aminophylline; Animals; Body Temperature Regulation; Cold Temperature; Drug Synergism; Male; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Xanthines	1989
Adenosine-induced bronchoconstriction in the guinea-pig isolated lung: interaction with theophylline and enprofylline. Pulmonary pharmacology, 1988, Volume: 1, Issue:2 Topics: Adenosine; Animals; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; In Vitro Techniques; Lung; Male; Theophylline; Xanthines	1988
Actions of enprofylline in the rat hippocampus. Acta physiologica Scandinavica, 1985, Volume: 123, Issue:2 Topics: Adenosine; Animals; Bronchodilator Agents; Cyclic AMP; Evoked Potentials; Felodipine; Hippocampus; Isoproterenol; Male; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline; Trifluoperazine; Xanthines	1985
Effects of enprofylline on A1 and A2 adenosine receptors. European journal of pharmacology, 1985, Oct-29, Volume: 117, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Diphosphate; Adenylyl Cyclases; Adipose Tissue; Animals; Blood Platelets; Bronchodilator Agents; Cell Membrane; Cyclic AMP; Guinea Pigs; Humans; In Vitro Techniques; Lung; Rats; Receptors, Cell Surface; Receptors, Purinergic; Stimulation, Chemical; Theophylline; Xanthines	1985
Effect of adenosine receptor agonists and other compounds on cyclic AMP accumulation in forskolin-treated hippocampal slices. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 332, Issue:2 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Hippocampus; Histamine; Isoproterenol; Male; Phenylisopropyladenosine; Prostaglandins E; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Xanthines	1986
Tracheal relaxation from combinations of xanthines and of a beta 2-receptor agonist and xanthines. Lung, 1986, Volume: 164, Issue:1 Topics: Animals; Drug Interactions; Guinea Pigs; Male; Muscle, Smooth; Terbutaline; Theophylline; Trachea; Xanthines	1986
Pharmacodynamics and pharmacokinetics of enprofylline and theophylline in the isolated rabbit heart. Pharmacology & toxicology, 1988, Volume: 63, Issue:3 Topics: Animals; Bronchodilator Agents; Female; Half-Life; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Rabbits; Theophylline; Xanthines	1988
The pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis and in patients with chronic renal disease. European journal of clinical pharmacology, 1988, Volume: 35, Issue:4 Topics: Adult; Aged; Bronchodilator Agents; Female; Humans; Kidney Failure, Chronic; Kidney Function Tests; Liver Cirrhosis; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Theophylline; Xanthines	1988
Creation of four consecutive instantaneous steady-state plasma concentration plateaus of theophylline and enprofylline by repeated infusions with exponentially decreasing delivery rates. European journal of clinical pharmacology, 1988, Volume: 35, Issue:6 Topics: Adult; Bronchodilator Agents; Humans; Infusions, Intravenous; Theophylline; Xanthines	1988
Effects of enprofylline, theophylline and terbutaline on second inward currents in papillary muscles from ferrets and guinea-pigs. Pharmacology & toxicology, 1988, Volume: 62, Issue:4 Topics: Action Potentials; Animals; Bronchodilator Agents; Female; Ferrets; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Terbutaline; Theophylline; Xanthines	1988
Selective activity of bamifylline on adenosine A1-receptors in rat brain. Pharmacological research communications, 1987, Volume: 19, Issue:8 Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Rats; Receptors, Purinergic; Theophylline; Xanthines	1987
Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study. Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 290, Issue:2 Topics: Female; Humans; In Vitro Techniques; Muscle Relaxation; Myometrium; Papaverine; Phosphodiesterase Inhibitors; Pregnancy; Theophylline; Uterine Contraction; Xanthines	1987
Bronchodilating plasma concentrations of enprofylline and theophylline have minor cardiovascular effects in man. Acta pharmacologica et toxicologica, 1986, Volume: 58, Issue:3 Topics: Adult; Blood Pressure; Bronchodilator Agents; Double-Blind Method; Heart Rate; Hemodynamics; Humans; Male; Myocardial Contraction; Theophylline; Xanthines	1986
Actions and interactions of adenosine, theophylline and enprofylline on the guinea-pig spirally cut trachea. European journal of pharmacology, 1986, Jun-24, Volume: 125, Issue:3 Topics: Adenosine; Animals; Bronchodilator Agents; Carbachol; Drug Interactions; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Theophylline; Trachea; Xanthines	1986
Relaxant effects of xanthines, a beta 2-receptor agonist and Ca2+ antagonists in guinea-pig tracheal preparations contracted by potassium or carbachol. European journal of pharmacology, 1986, Aug-22, Volume: 128, Issue:1-2 Topics: Animals; Bronchodilator Agents; Carbachol; Female; Guinea Pigs; Male; Muscle, Smooth; Nimodipine; Parasympatholytics; Potassium; Terbutaline; Theophylline; Trachea; Verapamil; Xanthines	1986
Simple and sensitive method for the simultaneous determination of enprofylline, theobromine, paraxanthine, theophylline and caffeine using high-performance liquid chromatography. Journal of chromatography, 1986, Aug-02, Volume: 380, Issue:2 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Theobromine; Theophylline; Xanthines	1986
Methylxanthines reduce in vitro human overall platelet metabolism as measured by microcalorimetry. Acta medica Scandinavica, 1986, Volume: 220, Issue:2 Topics: Blood Platelets; Body Temperature Regulation; Caffeine; Calorimetry; Humans; Theophylline; Xanthines	1986
Characterization of the antinociceptive effects of some adenosine analogues in the rat. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 334, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Dose-Response Relationship, Drug; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Theophylline; Xanthines	1986
Relaxation of lower esophageal sphincter and stimulation of gastric secretion and diuresis by antiasthmatic xanthines. Role of adenosine antagonism. The American review of respiratory disease, 1985, Volume: 131, Issue:1 Topics: Adult; Diuresis; Esophagogastric Junction; Gastric Mucosa; Gastrins; Humans; Male; Pressure; Theophylline; Xanthines	1985
Enprofylline and theophylline on small human placental arteries: studies of in vitro effects and mode of action. Acta pharmacologica et toxicologica, 1985, Volume: 56, Issue:2 Topics: Arteries; Bronchodilator Agents; Calcium; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Placenta; Potassium; Pregnancy; Prostaglandins; Theophylline; Vasoconstriction; Vasodilation; Xanthines	1985
Pharmacokinetics of theophylline and enprofylline in patients requiring a high or low dose of theophylline. European journal of clinical pharmacology, 1985, Volume: 29, Issue:1 Topics: Bronchodilator Agents; Female; Half-Life; Humans; Kinetics; Male; Theophylline; Xanthines	1985
Adenosine receptor mediated inhibition of noradrenaline release from slices of the rat hippocampus. Life sciences, 1984, Nov-05, Volume: 35, Issue:19 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Dipyridamole; Electric Stimulation; Hippocampus; Male; Norepinephrine; Phenylisopropyladenosine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Rolipram; Theophylline; Xanthines	1984
Adenosine mechanisms in the regulation of breathing in the rat. European journal of pharmacology, 1984, Oct-30, Volume: 106, Issue:1 Topics: Adenosine; Animals; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Dose-Response Relationship, Drug; Heart Rate; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Respiration; Respiratory Function Tests; Stereoisomerism; Theophylline; Xanthines	1984
Characterization of adenosine receptors in isolated cerebral arteries of cat. British journal of pharmacology, 1983, Volume: 80, Issue:4 Topics: Adenosine; Animals; Cats; Cerebral Arteries; Cyclic AMP; Female; In Vitro Techniques; Male; Receptors, Purinergic; Theophylline; Vasoconstriction; Xanthines	1983
Tracheal relaxant and cardiostimulant actions of xanthines can be differentiated from diuretic and CNS-stimulant effects. Role of adenosine antagonism? Life sciences, 1982, Dec-13, Volume: 31, Issue:24 Topics: Adenosine; Animals; Bronchodilator Agents; Cardiotonic Agents; Central Nervous System Stimulants; Diuretics; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Theophylline; Trachea; Xanthines	1982
Effects of enprofylline and theophylline on purified human basophils. Allergy, 1984, Volume: 39, Issue:7 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Basophils; Histamine Release; Humans; In Vitro Techniques; Theophylline; Xanthines	1984
Differentiation between bronchodilation and universal adenosine antagonism among xanthine derivatives. Life sciences, 1982, Jun-21, Volume: 30, Issue:25 Topics: Adenosine; Animals; Bronchodilator Agents; Dipyridamole; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; Male; Mice; Motor Activity; Muscle, Smooth; Myenteric Plexus; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Trachea; Xanthines	1982
Effects on aggregation of human platelets of two xanthines and their interactions with adenosine. Acta physiologica Scandinavica, 1984, Volume: 120, Issue:1 Topics: Adenosine Diphosphate; Drug Interactions; Humans; Platelet Aggregation; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Xanthines	1984
Protein binding of enprofylline. European journal of clinical pharmacology, 1983, Volume: 25, Issue:5 Topics: Albumins; Animals; Blood Proteins; Dialysis; Dogs; Haplorhini; Humans; Hydrogen-Ion Concentration; Protein Binding; Rats; Species Specificity; Temperature; Theophylline; Ultrafiltration; Xanthines	1983
Potent bronchodilating effects of enprofylline and theophylline on contractions induced by egg albumin or by slow reacting substance (SRS). Acta pharmacologica et toxicologica, 1984, Volume: 55, Issue:2 Topics: Adenosine Deaminase; Albumins; Animals; Bronchi; Female; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; SRS-A; Theophylline; Trachea; Xanthines	1984
Dissociation of effects of xanthine analogs on renal prostaglandins and renal excretory function in the awake rat. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Consciousness; Dinoprost; Dinoprostone; Diuresis; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Kidney; Male; Meclofenamic Acid; Natriuresis; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Xanthines	1983
Seizure activity in animals given enprofylline and theophylline, two xanthines with partly different mechanisms of action. Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 258, Issue:2 Topics: Animals; Cats; Convulsants; Female; Guinea Pigs; Hemodynamics; Male; Mice; Motor Activity; Respiration; Salivation; Species Specificity; Theophylline; Time Factors; Xanthines	1982
Enprofylline, a principally new antiasthmatic xanthine. Acta pharmacologica et toxicologica, 1981, Volume: 49, Issue:4 Topics: Animals; Asthma; Cats; Guinea Pigs; In Vitro Techniques; Male; Mice; Theophylline; Xanthines	1981
Adenosine antagonism, a less desirable characteristic of xanthine asthma drugs? Acta pharmacologica et toxicologica, 1981, Volume: 49, Issue:4 Topics: Adenosine; Animals; Asthma; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Motor Activity; Muscle Contraction; Muscle, Smooth; Rats; Theophylline; Xanthines	1981
Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes. Biochemical pharmacology, 1993, Feb-24, Volume: 45, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Dogs; Humans; Isoenzymes; Phosphodiesterase Inhibitors; Purinergic Antagonists; Pyrrolidinones; Rats; Receptors, Purinergic; Rolipram; Theophylline; Xanthines	1993
Effects of alkylxanthines on contractility of diaphragm fibres isolated from normal and sensitized guinea-pigs. The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:12 Topics: Adenosine; Animals; Bronchodilator Agents; Caffeine; Calcium; Culture Media; Dantrolene; Diaphragm; Electric Stimulation; Extracellular Space; Female; Guinea Pigs; Immunization; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Serum Albumin, Bovine; Theobromine; Theophylline; Verapamil; Xanthines	1993
Effects of adenosine agonists and antagonists on pulmonary ventilation in conscious rats. General pharmacology, 1993, Volume: 24, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Body Temperature; Bronchoconstriction; Bronchodilator Agents; Lung; Male; Naloxone; Narcotics; Phenylisopropyladenosine; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Theophylline; Vasodilator Agents; Xanthines	1993
Influence of prolonged adenosine receptor blockade on fetal sleep and breathing patterns. Respiration physiology, 1993, Volume: 91, Issue:2-3 Topics: Animals; Apnea; Female; Fetus; Infusions, Intravenous; Phenylisopropyladenosine; Pregnancy; Purinergic Antagonists; Receptors, Purinergic; Respiration; Sheep; Sleep; Sleep, REM; Theophylline; Xanthines	1993
Acetylcholine-induced bronchoconstriction modified by noise exposure in normal but not in sensitized guinea-pigs. Journal of autonomic pharmacology, 1996, Volume: 16, Issue:2 Topics: Acetylcholine; Airway Resistance; Animals; Antigens; Bronchoconstriction; Bronchodilator Agents; Butoxamine; Chymotrypsin; Guinea Pigs; Immunization; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Noise; Ovalbumin; Parasympathetic Nervous System; Stress, Physiological; Theophylline; Trachea; Xanthines	1996
Effects of selective and non-selective phosphodiesterase inhibitors on tracheal mucus secretion in the rat. European journal of pharmacology, 1996, Mar-18, Volume: 298, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; In Vitro Techniques; Isoenzymes; Male; Mucus; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Theophylline; Trachea; Xanthines	1996
Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Acoustic Stimulation; Animals; Caffeine; Convulsants; Dyphylline; Electroencephalography; Epilepsy; Female; Lipid Metabolism; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines	1997
Structure-related pharmacokinetics of xanthines after direct administration into the peritoneal cavity of rats. Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:10 Topics: Animals; Bronchodilator Agents; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Structure-Activity Relationship; Theophylline; Xanthines	1997
Theophylline-induced recovery in a hemidiaphragm paralyzed by hemisection in rats: contribution of adenosine receptors. Neuropharmacology, 1998, Volume: 37, Issue:1 Topics: Animals; Bronchodilator Agents; Diaphragm; Electrophysiology; Female; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Theophylline; Xanthines	1998
Adenosine and adenosine antagonism in asthma. Thorax, 1998, Volume: 53, Issue:5 Topics: Adenosine; Anti-Asthmatic Agents; Humans; Theophylline; Xanthines	1998
Theophylline dilates rat diaphragm arterioles via the prostaglandins pathway. British journal of pharmacology, 1998, Volume: 124, Issue:7 Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Diaphragm; Male; Nitric Oxide; Prostaglandins; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Theophylline; Vasodilator Agents; Xanthines	1998
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular pharmacology, 1999, Volume: 56, Issue:4 Topics: Animals; Anti-Asthmatic Agents; Blotting, Western; Calcium; Cell Degranulation; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Kidney; Mast Cells; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Theophylline; Type C Phospholipases; Xanthines	1999
Attenuation of the development of morphine dependence/tolerance by nefiracetam: involvement of adenosine 3':5'-cyclic monophosphate system. Behavioural brain research, 2000, Volume: 115, Issue:1 Topics: Animals; Brain Chemistry; Cerebral Cortex; Cyclic AMP; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Phosphodiesterase Inhibitors; Psychotropic Drugs; Pyrrolidinones; Substance Withdrawal Syndrome; Theophylline; Xanthines	2000
Alkylxanthine-induced recovery of respiratory function following cervical spinal cord injury in adult rats. Experimental neurology, 2001, Volume: 168, Issue:1 Topics: Animals; Bronchodilator Agents; Cervical Vertebrae; Diaphragm; Dose-Response Relationship, Drug; Female; Functional Laterality; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Spinal Cord Injuries; Theophylline; Xanthines	2001
Role of adenosine in asthma. Drug development research, 1996, Volume: 39 Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Anti-Asthmatic Agents; Asthma; Bronchoconstriction; Bronchodilator Agents; Dogs; Humans; Lung; Mast Cells; Mice; Rats; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-2; Theophylline; Xanthines	1996
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. British journal of pharmacology, 2001, Volume: 134, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines	2001
Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009, Volume: 39, Issue:12 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Adult; Apoptosis; Caspase 3; CD11c Antigen; Cell Differentiation; Dendritic Cells; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Interleukin-4; Male; Monocytes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptors, Purinergic P1; Recombinant Proteins; RNA, Small Interfering; Rolipram; Theophylline; Xanthines	2009