theophylline has been researched along with enoxacin in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (35.21) | 18.7374 |
| 1990's | 18 (25.35) | 18.2507 |
| 2000's | 3 (4.23) | 29.6817 |
| 2010's | 25 (35.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G | 1 |
| Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y | 1 |
| Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L | 1 |
| Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L | 1 |
| Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L | 2 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X | 1 |
| Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y | 1 |
| An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z | 1 |
| Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P | 1 |
| Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G | 1 |
| Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C | 1 |
| Granneman, GR; Mahr, G; Muth, P; Nickel, P; Sörgel, F; Stephan, U | 1 |
| LeBel, M; Parent, M | 1 |
| Apichartpichean, R; Hasegawa, T; Muraoka, I; Nabeshima, T; Nadai, M; Takagi, K | 1 |
| Apichartpichean, R; Hasegawa, T; Kuzuya, T; Nabeshima, T; Nadai, M; Nitta, A; Takagi, K | 1 |
| Hasegawa, T; Kuzuya, T; Muraoka, I; Nadai, M; Takagi, K; Yoshizumi, H | 1 |
| Harris, JM | 1 |
| Guzelian, PS; Hunt, C; Karnes, HT; Polk, RE; Sarkar, M | 1 |
| Nakanishi, S; Okuno, H | 1 |
| Colburn, WA; Koup, JR; Posvar, E; Sedman, AJ; Toothaker, RD | 1 |
| Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, GJ | 1 |
| Goto, M; Kawakatsu, K; Sano, M; Takeyama, M; Yamamoto, I; Yamashina, H | 1 |
| Hashimoto, M; Kamaura, M; Mizuki, Y; Sekine, Y; Yamaguchi, T | 1 |
| Hoffman, A; Levy, G | 1 |
| Koup, JR; Rogge, MC; Sedman, AJ; Solomon, WR; Wagner, JG; Welling, PG | 1 |
| Beer, C; Harder, S; Papenburg, A; Shah, PM; Staib, AH; Stille, W | 1 |
| Blogie, M; Carpiaux, JP; Glupczynski, Y; Prigogine, T; Schmerber, JS; Yourassowsky, E | 1 |
| Mulder, GJ; Nagelkerke, JF; Tijdens, RB; Van der Mark, EJ; Wijnands, WJ | 1 |
| Hasegawa, T; Satake, T; Suzuki, R; Takagi, K; Watanabe, T; Yamaki, K | 1 |
| Rogge, MC; Sedman, AJ; Solomon, WR; Toothaker, RD; Wagner, JG; Welling, PG | 1 |
| Hasegawa, T; Kitazawa, S; Ogura, Y; Satake, T; Suzuki, R; Takagi, K; Watanabe, T; Yamaki, K | 1 |
| Goto, M; Kawakatsu, K; Ohkita, C; Sano, M; Takeyama, M; Yamamoto, I; Yamashina, H | 1 |
| De Witte, TM; Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, WJ | 1 |
| Arnaud, A; Frances, Y; Nourrit, J; Philip-Joet, F | 1 |
| Van Herwaarden, CL; Vree, TB; Wijnands, WJ | 3 |
| Beer, C; Frech, K; Harder, S; Mieke, S; Shah, PM; Staib, AH; Stille, W | 1 |
| Popovski, Z; Rybak, MJ | 1 |
| van Herwaarden, CL; Vree, TB; Wijnands, GJ | 1 |
| Beckmann, J; Elsässer, W; Gundert-Remy, U; Hertrampf, R | 1 |
| Miyazaki, K; Okazaki, O; Tachizawa, H | 1 |
| Baars, AM; van Herwaarden, CL; Vree, TB; Wijnands, WJ | 1 |
| Arnaud, A; Frances, Y; Joet, FP; Nourrit, J | 1 |
| Aarons, L; Davis, JD; Houston, JB | 3 |
| Korrapati, MR; Muppalla, S; Vestal, RE; Wei, X; Zhai, S | 1 |
| Konishi, H; Morita, K; Yamaji, A | 1 |
| Fujiwara, I; Mizuki, Y; Sekine, Y; Yamaguchi, T | 1 |
| Bezek, S; Kukan, M; Pool, WF; Woolf, TF | 1 |
| Kunze, KL; Parker, BM; Vestal, RE; Wei, X; Zhai, S | 1 |
| Bao, D; Kuang, X; Liu, D | 1 |
| Homma, M; Kobayashi, D; Kobayashi, T; Kohda, Y; Momo, K | 1 |
| Alder, J; Brown, HS; Houston, JB; Wilby, AJ | 1 |
| Gao, M; Igata, H; Ikegaya, Y; Sato, K; Takeuchi, A | 1 |
| Gao, M; Ikegaya, Y; Sato, M | 1 |
2 review(s) available for theophylline and enoxacin
| Article | Year |
|---|---|
Meta-analysis of quinolone-theophylline interactions.
Topics: Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Meta-Analysis as Topic; Quinolones; Theophylline | 1991 |
[Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect].
Topics: Animals; Diphenhydramine; Drug Discovery; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Enoxacin; Forecasting; Humans; Machine Learning; Mice; Seizures; Strychnine; Theophylline | 2018 |
6 trial(s) available for theophylline and enoxacin
| Article | Year |
|---|---|
Effects of 2 quinolone antibacterials, temafloxacin and enoxacin, on theophylline pharmacokinetics.
Topics: Administration, Oral; Adult; Aminophylline; Anti-Infective Agents; Double-Blind Method; Drug Interactions; Enoxacin; Fluoroquinolones; Humans; Injections, Intravenous; Male; Quinolones; Theophylline | 1992 |
4-quinolones inhibit biotransformation of caffeine.
Topics: Adult; Biotransformation; Caffeine; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Interactions; Enoxacin; Humans; Male; Molecular Structure; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones; Random Allocation; Theophylline | 1988 |
Enoxacin in acute exacerbations of chronic bronchitis: a comparison with amoxycillin.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Bronchitis; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Enoxacin; Gram-Negative Bacteria; Haemophilus influenzae; Humans; Middle Aged; Moraxella catarrhalis; Naphthyridines; Neisseria meningitidis; Pseudomonas aeruginosa; Random Allocation; Theophylline | 1988 |
[Gyrase inhibitors can delay caffeine elimination].
Topics: Caffeine; Ciprofloxacin; Enoxacin; Humans; Naphthyridines; Theophylline | 1986 |
Effect of fluconazole on theophylline disposition in humans.
Topics: Adult; Cross-Over Studies; Enoxacin; Female; Fluconazole; Humans; Male; Metabolic Clearance Rate; Theophylline; Uric Acid; Xanthines | 1994 |
Relation between plasma and saliva concentrations of enoxacin, ciprofloxacin, and theophylline.
Topics: Adult; Anti-Infective Agents; Bronchodilator Agents; Ciprofloxacin; Drug Interactions; Enoxacin; Female; Humans; Male; Protein Binding; Saliva; Theophylline | 1996 |
63 other study(ies) available for theophylline and enoxacin
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats | 2015 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine | 2016 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2017 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine | 2017 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine | 2017 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship | 2017 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2018 |
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2018 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship | 2018 |
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates | 2019 |
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship | 2019 |
Pharmacokinetic characteristics of N7-substituted theophylline derivatives and their interaction with quinolone in rats.
Topics: Aminophylline; Animals; Blood Proteins; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Drug Interactions; Dyphylline; Enoxacin; Kidney Tubules; Male; Protein Binding; Quinolones; Rats; Rats, Inbred Strains; Theophylline | 1991 |
Structure-related inhibitory effect of quinolones on alkyl-xanthine elimination in rats.
Topics: Animals; Enoxacin; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Theophylline; Xanthines | 1991 |
Effects of enoxacin on renal and metabolic clearance of theophylline in rats.
Topics: Animals; Enoxacin; Kidney; Male; Rats; Rats, Inbred Strains; Theophylline; Uric Acid | 1990 |
Drug interactions affecting theophylline clearance.
Topics: Adolescent; Adult; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Propranolol; Theophylline | 1990 |
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Hydroxylation; Microsomes, Liver; Norfloxacin; Theophylline; Uric Acid; Xanthines | 1990 |
Comparison of inhibitory effects of new quinolones on drug metabolizing activity in the liver.
Topics: Acetaminophen; Animals; Anti-Infective Agents; Enoxacin; Glutathione; Liver; Liver Function Tests; Male; Microsomes, Liver; Mixed Function Oxygenases; Norfloxacin; Ofloxacin; Rats; Theophylline | 1990 |
Theophylline dosage adjustment during enoxacin coadministration.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Female; Humans; Male; Theophylline | 1990 |
Drug-drug interactions affecting fluoroquinolones.
Topics: Adult; Drug Interactions; Enoxacin; Humans; Male; Ofloxacin; Oxidation-Reduction; Theophylline; Uric Acid; Xanthines | 1989 |
Inhibitory effect of enoxacin, ofloxacin and norfloxacin on renal excretion of theophylline in humans.
Topics: Adult; Drug Interactions; Enoxacin; Female; Humans; Kidney; Male; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Theophylline | 1989 |
Interaction of enoxacin with theophylline in rats.
Topics: Animals; Biotransformation; Enoxacin; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Theophylline | 1989 |
Effect of enoxacin on theophylline neurotoxicity.
Topics: Animals; Body Temperature; Body Weight; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Infusions, Parenteral; Male; Rats; Rats, Inbred Lew; Seizures; Theophylline | 1989 |
The theophylline-enoxacin interaction: II. Changes in the disposition of theophylline and its metabolites during intermittent administration of enoxacin.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Humans; Male; Middle Aged; Theophylline; Time Factors; Xanthines | 1989 |
Inhibition of the oxidative metabolism of theophylline in isolated rat hepatocytes by the quinolone antibiotic enoxacin and its metabolite oxoenoxacin, but not by ofloxacin.
Topics: Animals; Enoxacin; In Vitro Techniques; Liver; Male; Naphthyridines; Ofloxacin; Oxazines; Oxidation-Reduction; Quinolines; Rats; Structure-Activity Relationship; Theophylline | 1988 |
Interaction between theophylline and enoxacin.
Topics: Adult; Anti-Infective Agents; Drug Interactions; Enoxacin; Humans; Male; Naphthyridines; Theophylline | 1988 |
The theophylline-enoxacin interaction: I. Effect of enoxacin dose size on theophylline disposition.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Humans; Male; Theophylline; Uric Acid; Xanthines | 1988 |
Comparative studies on interaction between theophylline and quinolones.
Topics: Adult; Anti-Infective Agents; Drug Interactions; Enoxacin; Fluoroquinolones; Homeostasis; Humans; Liver; Male; Naphthyridines; Osmolar Concentration; Quinolines; Theophylline; Urine | 1988 |
Effects of enoxacin, ofloxacin and norfloxacin on theophylline disposition in humans.
Topics: 17-Hydroxycorticosteroids; Adult; Aminophylline; Enoxacin; Female; Humans; Hydrocortisone; Male; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Theophylline | 1988 |
The influence of ofloxacin and enoxacin on the metabolic pathways of theophylline in healthy volunteers. A pilot study.
Topics: Adult; Dealkylation; Drug Interactions; Enoxacin; Humans; Kidney; Male; Ofloxacin; Oxidation-Reduction; Theophylline | 1988 |
Enoxacin in the treatment of lower respiratory tract infections.
Topics: Acute Disease; Adult; Aged; Anti-Bacterial Agents; Bronchiectasis; Bronchitis; Chronic Disease; Drug Evaluation; Drug Resistance, Microbial; Drug Therapy, Combination; Enoxacin; Female; Haemophilus influenzae; Humans; Legionella; Lung Diseases, Obstructive; Male; Middle Aged; Naphthyridines; Pneumonia; Pseudomonas; Recurrence; Streptococcus pneumoniae; Theophylline | 1988 |
The effect of the 4-quinolone enoxacin on plasma theophylline concentrations.
Topics: Adult; Aged; Anti-Infective Agents; Drug Interactions; Enoxacin; Female; Half-Life; Humans; Male; Middle Aged; Naphthyridines; Respiratory Tract Infections; Theophylline; Time Factors | 1986 |
[Enoxacin and theophylline].
Topics: Drug Interactions; Enoxacin; Humans; Lung Diseases, Obstructive; Naphthyridines; Theophylline | 1986 |
Potential theophylline toxicity with enoxacin.
Topics: Anti-Infective Agents; Drug Interactions; Enoxacin; Humans; Naphthyridines; Theophylline | 1986 |
Potential theophylline toxicity with enoxacin.
Topics: Drug Interactions; Enoxacin; Humans; Metabolic Clearance Rate; Naphthyridines; Theophylline | 1987 |
Enoxacin--a potent inhibitor of theophylline metabolism.
Topics: Adult; Anti-Infective Agents; Enoxacin; Humans; Naphthyridines; Theophylline; Uric Acid; Xanthines | 1987 |
Lack of effect of ofloxacin on theophylline pharmacokinetics in rats.
Topics: Animals; Anti-Infective Agents; Blood Proteins; Cimetidine; Enoxacin; Male; Microsomes, Liver; Naphthyridines; Ofloxacin; Oxazines; Oxidoreductases; Protein Binding; Rats; Theophylline | 1987 |
Steady-state kinetics of the quinolone derivatives ofloxacin, enoxacin, ciprofloxacin and pefloxacin during maintenance treatment with theophylline.
Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Drug Interactions; Enoxacin; Female; Humans; Male; Middle Aged; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines; Theophylline | 1987 |
Enoxacin in the treatment of bronchopulmonary infections.
Topics: Anti-Infective Agents; Enoxacin; Female; Humans; Male; Middle Aged; Naphthyridines; Respiratory Tract Infections; Theophylline | 1985 |
Enoxacin decreases the clearance of theophylline in man.
Topics: Adult; Aged; Depression, Chemical; Enoxacin; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Naphthyridines; Protein Binding; Theophylline; Time Factors | 1985 |
Enoxacin raises plasma theophylline concentrations.
Topics: Anti-Infective Agents; Drug Interactions; Enoxacin; Humans; Naphthyridines; Pseudomonas Infections; Theophylline | 1984 |
Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes.
Topics: Animals; Anti-Infective Agents; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Enoxacin; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Xanthines | 1995 |
Simultaneous determination of theophylline, enoxacin and ciprofloxacin in human plasma and saliva by high-performance liquid chromatography.
Topics: Anti-Infective Agents; Bronchodilator Agents; Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Humans; Male; Reproducibility of Results; Saliva; Theophylline | 1995 |
Relationship between enoxacin and ciprofloxacin plasma concentrations and theophylline disposition.
Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Theophylline | 1994 |
Simultaneous assay of fluoroquinolones and theophylline in plasma by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Male; Norfloxacin; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theophylline | 1993 |
Structure-related inhibitory effect of antimicrobial enoxacin and derivatives on theophylline metabolism by rat liver microsomes.
Topics: Animals; Anti-Infective Agents; Crystallography, X-Ray; Electrochemistry; Enoxacin; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Molecular Structure; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Theophylline; Uric Acid | 1996 |
The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations.
Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Enoxacin; Enzyme Induction; Etimizol; Glucuronidase; Glutathione; Liver; Male; Methylcholanthrene; Rats; Rats, Wistar; Tacrine; Theophylline | 1996 |
[Effect of enoxacin on pharmacokinetics of theophylline in rats].
Topics: Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; Drug Synergism; Enoxacin; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Theophylline | 1999 |
A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enoxacin; Humans; Male; Norfloxacin; Reproducibility of Results; Sensitivity and Specificity; Theophylline | 2011 |
Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: transporter-enzyme interplay.
Topics: Animals; Cell Separation; Clarithromycin; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enoxacin; Enzyme Inhibitors; Hepatocytes; Male; Microsomes, Liver; Midazolam; Nelfinavir; Rats; Rats, Sprague-Dawley; Saquinavir; Theophylline | 2010 |
Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds.
Topics: Animals; CA1 Region, Hippocampal; Diphenhydramine; Enoxacin; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Seizures; Strychnine; Support Vector Machine; Theophylline | 2017 |