Compounds > theophylline

theophylline and drotaverin

theophylline has been researched along with drotaverin in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19903 (27.27)18.7374
1990's2 (18.18)18.2507
2000's2 (18.18)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Marton, S; Szentmiklósi, P2
Blaskó, G; Hermecz, I; Kapui, Z; Sarkadi, B; Szentmiklósi, P; Tardos, L1
Kökény, G; Sebestyén, G; Szentmiklósi, P; Zájer, J1
Sylvia, M1
Guttman, A; Mikus, EG; Patai, Z1

Other Studies

11 other study(ies) available for theophylline and drotaverin

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
[Practical significance of drug equivalence in preclinical research, with special reference to drotaverin and its salt with theophylline-7-acetic acid].
    Acta pharmaceutica Hungarica, 1979, Volume: 49, Issue:2

    Topics: Animals; Biological Availability; Drug Evaluation, Preclinical; Mice; Papaverine; Theophylline

1979
Comparative studies of drotaverine--acephyllinate (Depogen) and pentoxifylline (Trental).
    Thrombosis research, 1992, Jun-15, Volume: 66, Issue:6

    Topics: Animals; Cell Aggregation; Drug Combinations; Drug Evaluation, Preclinical; Erythrocytes; Humans; Leukocytes; Papaverine; Pentoxifylline; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 3; Rabbits; Theophylline

1992
Biopharmaceutical aspects of Depogen.
    Die Pharmazie, 1983, Volume: 38, Issue:9

    Topics: Animals; Biopharmaceutics; Diffusion; Dogs; Drug Combinations; Female; Male; Mice; Models, Biological; Papaverine; Rats; Theophylline

1983
Effects of drotaverin and depogen on gastric emptying in beagle dogs.
    Acta veterinaria Academiae Scientiarum Hungaricae, 1981, Volume: 29, Issue:2

    Topics: Animals; Chemical Phenomena; Chemistry; Dogs; Drug Combinations; Female; Gastric Emptying; Male; Papaverine; Parasympatholytics; Theophylline

1981
[Interspecies allometric scaling in pharmacokinetics of drugs].
    Acta pharmaceutica Hungarica, 1998, Volume: 68, Issue:6

    Topics: Animals; Body Weight; Cats; Dogs; Drug Combinations; Humans; Mice; Organ Size; Papaverine; Parasympatholytics; Rats; Regression Analysis; Species Specificity; Theophylline; Tissue Distribution

1998
Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine.
    Pharmacology, 2018, Volume: 101, Issue:3-4

    Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Papaverine; Phosphodiesterase Inhibitors; Theophylline; Trachea

2018