theophylline has been researched along with doxofylline in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (14.29) | 18.7374 |
| 1990's | 12 (15.58) | 18.2507 |
| 2000's | 12 (15.58) | 29.6817 |
| 2010's | 31 (40.26) | 24.3611 |
| 2020's | 11 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Cirillo, R; Franzone, JS; Reboani, MC | 2 |
| Bianchi Porro, G; Grossi, E; Lazzaroni, M | 1 |
| Bizzarri, M; Lagana, A; Mancini, M; Marino, A | 1 |
| Dorizzi, R; Frigerio, A; Marigo, M; Tagliaro, F | 1 |
| Balzano, G; Campisi, V; Capone, M; De Felice, A; Di Filippo, A; Foddai, G; Franzone, JS; Grossi, E; Jodice, F; Melillo, G | 1 |
| Bagnato, G; Bottari, M; Fodale, P | 1 |
| Biffignandi, P; Cirillo, R; Franzone, JS | 1 |
| Cirillo, R; Franzone, JS; Grossi, E | 1 |
| Bernasconi, M; Brandolese, R; Manzin, E; Poggi, R; Rossi, A | 1 |
| Allegra, A; Bagnato, GF; Buemi, AL; Cinquegrani, M; De Leo, A; Giacobbe, MS; Leotta, G; Mileto, A; Scibilia, M; Spina, E | 1 |
| Biffignandi, P; Franzone, JS; Grossi, E | 1 |
| Barone, D; Cirillo, R; Franzone, JS | 1 |
| Di Carlo, R; Fonzo, D; Franzone, JS; Reboani, C | 1 |
| Badini, C; Franzone, JS; Masera, F | 1 |
| Cravanzola, C; Franzone, JS; Masera, F | 1 |
| Braghiroli, A; Donner, CF; Grossi, E; Sacco, C | 1 |
| Bettini, R; Cani, E; Cortellini, G; Dini, FL; Garagnani, A; Gobbi, G; Greco, A; Onorato, G; Pasini, G; Pasini, P | 1 |
| Adachi, M; Horikoshi, S; Idaira, K; Imai, T; Okamoto, M; Sugeta, A | 1 |
| De Maria, P; Galimberti, M; Ronchi, E; Villani, F | 1 |
| Checchini, M; Franzini, C; Magni, M; Omboni, E; Scaglione, M; Vaccarella, A | 1 |
| De Sarro, A; De Sarro, G; Grasso, S; Nava, F; Zappala, M | 1 |
| Guo, H; He, LY; Huang, JH; Xu, XY | 1 |
| Cogo, R; Dini, FL | 1 |
| Barr, RG; Camargo, CA; Rowe, BH | 2 |
| Chervinsky, P; Goldstein, MF | 1 |
| Bense, L | 1 |
| Chen, JS; Lin, HQ; Zhang, JX | 1 |
| Cai, CQ; Cai, SX; Zhao, HJ; Zhou, B; Zou, F | 1 |
| Mullangi, R; Narasu, ML; Shankar, BP; Sreenivas, N | 1 |
| Kabra, SK; Lodha, R; Sankar, J | 1 |
| He, HB; Huang, HF; Lu, Y; Tang, X | 1 |
| Santra, CK | 1 |
| Chakraborty, S; Mishra, B; Shukla, D; Singh, S | 1 |
| Page, CP | 1 |
| Feng, E; Su, L; Xu, F; Xu, G | 2 |
| Hu, Y; Li, C; Li, F; Liu, X; Luo, G; Ma, J; Sun, J; Wang, J; Wang, T; Xiong, S; Xiong, W; Xu, Y; Zhang, Z; Zhao, J; Zhao, S; Zuo, P | 1 |
| Chakraborty, S; Mishra, B; Shukla, D | 2 |
| Allegra, L; Jolas, T; Page, CP; van Mastbergen, J | 1 |
| Kang, HR; Kang, MG; Shim, EJ; Sohn, SW; Song, WJ | 1 |
| Naidu, ChG; Prasad, KG; Rao, RN; Saida, S; Santhakumar, B | 1 |
| Agwane, SB; Naidu, ChG; Prasad, KG; Rao, RN; Saida, S | 1 |
| Gao, J; Gao, P; Li, XP; Liu, D; Zhang, CL | 1 |
| Man, F; Page, CP; Riffo-Vasquez, Y | 1 |
| Ilango, K; Nageswari, AD; Rajanandh, MG | 2 |
| Ji, N; Wang, J; Yin, L; Zhao, Y | 1 |
| Kumar, R; Lal, D; Manocha, S; Ray, A; Vijayan, VK | 1 |
| Franco, R; Martínez-Pinilla, E; Oñatibia-Astibia, A | 1 |
| Aswini, KK; Biju, VM; Vinu Mohan, AM | 1 |
| Gao, H; Nan, Y; Wang, J; Zeng, K; Zhang, Y; Zheng, X | 1 |
| Caputi, AP; Marcellusi, A; Marcobelli, A; Mennini, FS; Russo, A; Sciattella, P | 1 |
| Ghosh, K; Goud P, SK; Jaywant, MA; Navalgund, SG; Pandey, AK; Pola, A; Raju, CK; S, G | 1 |
| Adams, E; Hong, L; Lu, J; Su, W; Van Schepdael, A; Zhu, P | 1 |
| Ammit, AJ; Baehring, G; Kugel, MJ; Patel, BS | 1 |
| Quanqing, M | 1 |
| Gunasekaran, S; Sasi Rekha, P | 1 |
| Page, CP; Riffo-Vasquez, Y; Venkatasamy, R | 1 |
| Cazzola, M; Matera, MG; Page, C | 1 |
| Calzetta, L; Cazzola, M; Matera, MG; Page, C; Rogliani, P | 1 |
| Barnes, PJ; Calzetta, L; Cazzola, M; Criner, GJ; Gabriella Matera, M; Martinez, FJ; Papi, A | 1 |
| Calzetta, L; Cazzola, M; Dini, FL; Fairweather, WR; Goldstein, MF; Hanania, NA; Howard, WW | 1 |
| Brunini, C; Fresu, LG; Massara, E; Talmon, M | 1 |
| Calzetta, L; Cazzola, M; Fairweather, WR; Goldstein, MF; Howard, WW; Matera, MG; Rogliani, P | 1 |
| Ge, G; Ma, H; Mao, M; Pan, Q; Qian, X; Song, P; Wang, H; Xia, S; Yang, L; Zhao, X; Zou, L | 1 |
| Cazzola, M; Matera, MG | 1 |
| Jiao, P; Li, W; Li, Y; Liu, Z; Shen, L; Yu, L | 1 |
| Ameen, F; Kausar, T; Nayeem, SM; Siddiqui, S; Tabish, M; Ur Rehman, S | 1 |
| Wang, Y | 1 |
| Chen, ZY; Gao, XH; Huang, CL; Lin, AM; Liu, CY; Wu, JH; Xu, XT; Zhang, Y | 1 |
| Bao, H; Du, X; Zhao, D | 1 |
| Chen, H; Li, J; Liu, Y; Shen, W; Xu, M; Yang, N; Yang, Y; Zhang, H; Zheng, Y | 1 |
| Chen, ZY; Chu, SQ; Li, Y; Lin, YM; Wu, JH; Xie, WX; Zhang, XQ; Zhang, Y | 1 |
| Canakci, ME; Sevik, OE | 1 |
13 review(s) available for theophylline and doxofylline
| Article | Year |
|---|---|
[Doxofylline: pharmacologic profile and a review of clinical studies].
Topics: Animals; Antitussive Agents; Humans; Theophylline | 1988 |
Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects.
Topics: Animals; Arrhythmias, Cardiac; Asthma; Bronchodilator Agents; Cardiovascular Diseases; Drug Evaluation, Preclinical; Humans; Lung Diseases, Obstructive; Phosphodiesterase Inhibitors; Pulmonary Heart Disease; Receptors, Purinergic P1; Risk Factors; Safety; Theophylline; Treatment Outcome; Xanthines | 2001 |
Methyl-xanthines for exacerbations of chronic obstructive pulmonary disease.
Topics: Aminophylline; Bronchodilator Agents; Humans; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Theophylline | 2001 |
Methylxanthines for exacerbations of chronic obstructive pulmonary disease: meta-analysis of randomised trials.
Topics: Administration, Oral; Aminophylline; Bronchodilator Agents; Forced Expiratory Volume; Humans; Infusions, Intravenous; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Theophylline; Treatment Outcome | 2003 |
Doxofylline: The next generation methylxanthine.
Topics: Asthma; Bronchodilator Agents; Child; Humans; Theophylline | 2008 |
Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Databases, Bibliographic; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline; Treatment Outcome | 2009 |
Doxofylline: a "novofylline".
Topics: Animals; Anti-Inflammatory Agents; Bronchodilator Agents; Clinical Trials as Topic; Drug Interactions; Humans; Lung Diseases; Theophylline | 2010 |
The potential of methylxanthine-based therapies in pediatric respiratory tract diseases.
Topics: Adolescent; Apnea; Asthma; Bronchodilator Agents; Caffeine; Child; Child, Preschool; Cough; Humans; Infant; Infant, Newborn; Infant, Premature; Phosphodiesterase Inhibitors; Theobromine; Theophylline; Xanthines | 2016 |
Doxofylline is not just another theophylline!
Topics: Animals; Asthma; Bronchodilator Agents; Disease Progression; Drug Interactions; Hospitalization; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Risk Factors; Theophylline; Treatment Outcome | 2017 |
Impact of doxofylline in COPD: A pairwise meta-analysis.
Topics: Bronchodilator Agents; Forced Expiratory Volume; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline; Treatment Outcome | 2018 |
Efficacy and safety profile of xanthines in COPD: a network meta-analysis.
Topics: Bronchodilator Agents; Forced Expiratory Volume; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Recovery of Function; Theophylline; Treatment Outcome; Xanthines | 2018 |
Impact of doxofylline compared to theophylline in asthma: A pooled analysis of functional and clinical outcomes from two multicentre, double-blind, randomized studies (DOROTHEO 1 and DOROTHEO 2).
Topics: Adult; Albuterol; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Randomized Controlled Trials as Topic; Theophylline | 2018 |
The effect of doxofylline in asthma and COPD.
Topics: Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Drug Costs; Economics, Pharmaceutical; Female; Humans; Male; Pulmonary Disease, Chronic Obstructive; Theophylline; Treatment Outcome | 2020 |
17 trial(s) available for theophylline and doxofylline
| Article | Year |
|---|---|
The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients.
Topics: Adult; Aminophylline; Asthma; Double-Blind Method; Duodenal Ulcer; Female; Gastric Acid; Gastric Juice; Gastrins; Humans; Injections, Intravenous; Male; Middle Aged; Theophylline | 1990 |
Treatment of reversible chronic airways obstruction with doxofylline compared with slow-release theophylline: a double-blind, randomized, multicentre trial.
Topics: Adolescent; Adult; Aged; Albuterol; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Respiratory Function Tests; Theophylline | 1989 |
[Clinical evaluation of doxofylline sachets in a pediatric population].
Topics: Antitussive Agents; Child; Double-Blind Method; Female; Humans; Male; Randomized Controlled Trials as Topic; Respiratory Function Tests; Respiratory Tract Diseases; Theophylline | 1989 |
The effects of doxofylline versus theophylline on sleep architecture in COPD patients.
Topics: Adult; Aged; Antitussive Agents; Arousal; Cross-Over Studies; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Polysomnography; Single-Blind Method; Sleep; Sleep Stages; Theophylline; Vital Capacity; Wakefulness | 1995 |
Methylxanthine drug therapy in chronic heart failure associated with hypoxaemia: double-blind placebo-controlled clinical trial of doxofylline versus theophylline and bamifylline.
Topics: Aged; Double-Blind Method; Echocardiography; Female; Heart; Heart Failure; Heart Rate; Humans; Hypoxia; Male; Middle Aged; Oxygen; Theophylline; Vasodilator Agents; Xanthines | 1993 |
Oral doxophylline in patients with chronic obstructive pulmonary disease.
Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Antitussive Agents; Blood Gas Analysis; Chromatography, High Pressure Liquid; Female; Forced Expiratory Flow Rates; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Respiratory Function Tests; Spirometry; Theophylline; Treatment Outcome | 1997 |
[Controlled clinical study of doxophylline versus aminophylline in the treatment of acute cardiorespiratory insufficiency syndromes].
Topics: Aminophylline; Antitussive Agents; Bronchodilator Agents; Cardiotonic Agents; Female; Heart Failure; Humans; Male; Middle Aged; Oxygen Consumption; Respiratory Insufficiency; Syndrome; Theophylline | 1997 |
Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma -- a double-blind randomized placebo-controlled multicentre clinical trial.
Topics: Adrenergic beta-Agonists; Albuterol; Anti-Asthmatic Agents; Asthma; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Forced Expiratory Volume; Gastrointestinal Diseases; Headache; Humans; Placebos; Respiratory Function Tests; Safety; Single-Blind Method; Tachycardia; Theophylline; Treatment Outcome | 2002 |
[Clinical study on doxofylline injection in treatment of children with acute asthma attacks].
Topics: Acute Disease; Asthma; Bronchodilator Agents; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Male; Theophylline; Treatment Outcome | 2004 |
Treatment of moderate chronic obstructive pulmonary disease (stable) with doxofylline compared with slow release theophylline--a multicentre trial.
Topics: Adult; Aged; Albuterol; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Spirometry; Theophylline; Treatment Outcome | 2008 |
Comparative study on the efficacy of tiotropium bromide inhalation and oral doxofylline treatment of moderate to severe stable chronic obstructive pulmonary disease.
Topics: Administration, Inhalation; Aged; Aged, 80 and over; Bronchodilator Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Scopolamine Derivatives; Theophylline; Tiotropium Bromide | 2011 |
Pulmonary function assessment in mild to moderate persistent asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide: a randomized controlled study.
Topics: Acetates; Adult; Asthma; Bronchodilator Agents; Budesonide; Cyclopropanes; Drug Therapy, Combination; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Middle Aged; Quinolines; Respiratory Function Tests; Sulfides; Theophylline; Tiotropium Bromide | 2014 |
Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: which is the best among the second-line treatment? A randomized trial.
Topics: Acetates; Adolescent; Adult; Asthma; Bronchodilator Agents; Budesonide; Cyclopropanes; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Male; Quinolines; Respiratory Function Tests; Sulfides; Theophylline; Tiotropium Bromide | 2015 |
The study of long term curative effect of chronic obstructive pulmonary disease in remission stage treated with TCM.
Topics: Acupressure; Acupuncture Therapy; Aged; Drugs, Chinese Herbal; Female; Humans; Male; Medicine, Chinese Traditional; Middle Aged; Oxygen; Pulmonary Disease, Chronic Obstructive; Qigong; Respiratory Function Tests; Theophylline | 2017 |
A long-term clinical trial on the efficacy and safety profile of doxofylline in Asthma: The LESDA study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Albuterol; Asthma; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Safety; Theophylline; Treatment Outcome | 2020 |
Theophylline Acetaldehyde as the Initial Product in Doxophylline Metabolism in Human Liver.
Topics: Acetaldehyde; Adult; Animals; Asthma; Bronchodilator Agents; Cytochrome P-450 Enzyme System; Female; Healthy Volunteers; Humans; Liver; Macaca fascicularis; Mice; Microsomes, Liver; Oxidation-Reduction; Pulmonary Disease, Chronic Obstructive; Rabbits; Rats; Theophylline | 2020 |
Efficacy and safety of combined doxofylline and salbutamol in treatment of acute exacerbation of chronic obstructive pulmonary disease.
Topics: Albuterol; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Theophylline | 2021 |
47 other study(ies) available for theophylline and doxofylline
| Article | Year |
|---|---|
Pharmacological studies in animals of beta-hydroxyethyltheophylline, the major metabolite of doxofylline in humans.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylcholine; Animals; Antitussive Agents; Blood Pressure; Bronchial Spasm; Bronchodilator Agents; Electrocardiography; Epinephrine; Female; Guinea Pigs; Humans; Ileum; Lethal Dose 50; Male; Movement; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; Receptors, Purinergic; Serotonin; Stimulation, Chemical; Theophylline; Trachea; Vagus Nerve | 1991 |
Doxofylline differs from methylxanthines in its movement of cytosolic calcium.
Topics: Aminophylline; Animals; Binding Sites; Blood Platelets; Calcium; Cytosol; Diltiazem; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Synaptosomes; Theophylline; Verapamil | 1991 |
Solid phase extraction and high performance liquid chromatographic determination of doxophylline in plasma.
Topics: Adult; Antitussive Agents; Chromatography, High Pressure Liquid; Female; Humans; Indicators and Reagents; Male; Spectrophotometry, Ultraviolet; Theophylline | 1990 |
Non-extraction HPLC method for simultaneous measurement of dyphylline and doxofylline in serum.
Topics: Chromatography, High Pressure Liquid; Dyphylline; Humans; Indicators and Reagents; Monitoring, Physiologic; Theophylline | 1990 |
Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF.
Topics: Airway Resistance; Anesthesia; Animals; Binding, Competitive; Bronchi; Bronchodilator Agents; Female; Guinea Pigs; In Vitro Techniques; Injections; Injections, Intravenous; Lung; Male; Muscle Contraction; Platelet Activating Factor; Pleurisy; Theophylline; Thromboxane A2 | 1989 |
Doxofylline, an adenosine-nonblocking xanthine, does not induce cardiostimulant effects.
Topics: Adenosine; Anesthesia; Animals; Blood Pressure; Cardiotonic Agents; Cats; Electric Stimulation; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Theophylline | 1989 |
Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure.
Topics: Bronchodilator Agents; Depression, Chemical; Female; Humans; Male; Middle Aged; Pulmonary Ventilation; Respiration, Artificial; Respiratory Insufficiency; Respiratory Mechanics; Theophylline; Time Factors | 1989 |
[Systemic cardiorespiratory effects induced by doxofylline].
Topics: Cardiovascular System; Female; Humans; Male; Middle Aged; Respiration; Respiratory Function Tests; Theophylline | 1989 |
Doxofylline and theophylline are xanthines with partly different mechanisms of action in animals.
Topics: Adenosine; Aminophylline; Animals; Diuresis; Gastric Acid; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Male; Mice; Motor Activity; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Natriuresis; Rats; Rats, Inbred Strains; Reference Values; Theophylline; Trachea | 1988 |
Pharmacological researches on 2-(7'-theophyllinemethyl)1,3-dioxolane.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Anesthetics, Local; Animals; Antitussive Agents; Bronchial Spasm; Central Nervous System; Gastrointestinal Motility; Guinea Pigs; Hemodynamics; In Vitro Techniques; Muscle, Smooth; Rabbits; Theophylline | 1981 |
[Assay of 2-(7'-theophyllinmethyl)-1,3-dioxolane using HPLC].
Topics: Chromatography, High Pressure Liquid; Dosage Forms; Theophylline | 1982 |
Preliminary studies on the absorption, distribution and excretion of 2-(7'theophyllinemethyl)-1,3-dioxolane in the rat.
Topics: Animals; Biotransformation; Intestinal Absorption; Kinetics; Male; Rats; Theophylline; Tissue Distribution | 1981 |
[Effects of theophylline and doxofylline on airway responsiveness in beagles].
Topics: Airway Resistance; Animals; Bronchi; Bronchodilator Agents; Dogs; Female; Respiration; Theophylline | 1997 |
Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats.
Topics: 1-Methyl-3-isobutylxanthine; Acoustic Stimulation; Animals; Caffeine; Convulsants; Dyphylline; Electroencephalography; Epilepsy; Female; Lipid Metabolism; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines | 1997 |
[Preliminary study on the absorption, distribution and excretion of doxophylline in rats].
Topics: Absorption; Animals; Antitussive Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Male; Rats; Rats, Wistar; Theophylline; Tissue Distribution | 1997 |
Conclusion without support - remarks on 'Efficacy and safely of doxyphyllin compared to Theophylline in chronic reversible asthma- a double-blind randomized placebo-controlled multicentre trial' by Goldstein MF, Chervinsky P (published in MedSciMonit, 200
Topics: Asthma; Bronchodilator Agents; Double-Blind Method; Humans; Multicenter Studies as Topic; Placebos; Randomized Controlled Trials as Topic; Research Design; Respiratory Function Tests; Theophylline | 2002 |
[Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma].
Topics: Adolescent; Adult; Asthma; Eosinophils; Female; Humans; Male; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Theophylline; Young Adult | 2005 |
Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of doxofylline in human serum: application to a clinical pharmacokinetic study.
Topics: Bronchodilator Agents; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Theophylline | 2008 |
Preparation and bioavailability of sustained-release doxofylline pellets in beagle dogs.
Topics: Acrylic Resins; Administration, Oral; Animals; Biological Availability; Bronchodilator Agents; Cellulose; Delayed-Action Preparations; Dogs; Hydrogen-Ion Concentration; Male; Methacrylates; Polymers; Solubility; Theophylline | 2008 |
Stability and compatibility of doxofylline with phentolamine mesilate in 0.9% sodium chloride or 5% dextrose injection for intravenous infusion.
Topics: Acids, Noncarboxylic; Adrenergic alpha-Antagonists; Bronchodilator Agents; Chemical Phenomena; Chromatography, High Pressure Liquid; Drug Combinations; Drug Compounding; Drug Stability; Drug Storage; Glucose; Hydrogen-Ion Concentration; Infusions, Intravenous; Phentolamine; Sodium Chloride; Temperature; Theophylline | 2011 |
In vitro and in vivo evaluation of multilayered pastilles for chronotherapeutic management of nocturnal asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Delayed-Action Preparations; Drug Carriers; Drug Chronotherapy; Drug Design; Drug Stability; Equipment Design; Male; Microscopy, Electron, Scanning; Polyethylene Glycols; Rats; Rats, Wistar; Silicon Dioxide; Solubility; Surface Properties; Technology, Pharmaceutical; Theophylline | 2012 |
The mechanism of action of doxofylline is unrelated to HDAC inhibition, PDE inhibition or adenosine receptor antagonism.
Topics: Bronchodilator Agents; Cell Line; Cell Membrane; Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Isoenzymes; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Regression Analysis; Reproducibility of Results; Theophylline; Transfection | 2012 |
Severe drug hypersensitivity induced by erdosteine and doxofylline as confirmed by patch and lymphocyte transformation tests: a case report.
Topics: Adult; Drug Hypersensitivity; Female; Humans; Lymphocyte Activation; Patch Tests; Theophylline; Thioglycolates; Thiophenes | 2012 |
Evaluation of in vivo behavior of controlled and pulsatile release pastilles using pharmacokinetic and γ-scintigraphic techniques.
Topics: Administration, Oral; Animals; Asthma; Biological Availability; Bronchodilator Agents; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Gastrointestinal Tract; Gastrointestinal Transit; Intestinal Mucosa; Male; Pharmaceutical Preparations; Pulmonary Disease, Chronic Obstructive; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Tablets; Tablets, Enteric-Coated; Technetium Tc 99m Pentetate; Theophylline | 2012 |
Doxofylline and methylprednisolone sodium succinate are stable and compatible under normal injection conditions.
Topics: Bronchodilator Agents; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Color; Drug Combinations; Drug Compounding; Drug Stability; Drug Storage; Glucocorticoids; Glucose; Hydrogen-Ion Concentration; Infusions, Intravenous; Injections; Methylprednisolone Hemisuccinate; Pharmaceutical Solutions; Sodium Chloride; Technology, Pharmaceutical; Temperature; Theophylline; Time Factors | 2013 |
Development and validation of a stability indicating assay of doxofylline by RP-HPLC: ESI-MS/MS, ¹H and ¹³C NMR spectroscopic characterization of degradation products and process related impurities.
Topics: Bronchodilator Agents; Carbon Isotopes; Chromatography, High Pressure Liquid; Limit of Detection; Magnetic Resonance Spectroscopy; Protons; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Theophylline | 2013 |
Development of a validated LC-MS/MS method for determination of doxofylline on rat dried blood spots and urine: application to pharmacokinetics.
Topics: Animals; Bronchodilator Agents; Chromatography, Liquid; Limit of Detection; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Theophylline | 2013 |
Effects of andrographolide on the pharmacokinetics of aminophylline and doxofylline in rats.
Topics: Aminophylline; Animals; Chromatography, High Pressure Liquid; Diterpenes; Drug Interactions; Male; Rats; Rats, Sprague-Dawley; Theophylline | 2013 |
Doxofylline, a novofylline inhibits lung inflammation induced by lipopolysacharide in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Bronchodilator Agents; Cell Movement; Disease Models, Animal; Dose-Response Relationship, Drug; Escherichia coli; Leukocytes; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Pneumonia; Theophylline | 2014 |
A non-invasive method for the determination of liquid injectables by Raman spectroscopy.
Topics: Algorithms; Drug Administration Routes; Levofloxacin; Principal Component Analysis; Spectrum Analysis, Raman; Theophylline | 2015 |
Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease.
Topics: Adult; Asthma; Bronchodilator Agents; Female; Humans; Male; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Theophylline | 2015 |
Molecularly imprinted poly(4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid) modified glassy carbon electrode as an electrochemical theophylline sensor.
Topics: Caffeine; Carbon; Dielectric Spectroscopy; Electrochemical Techniques; Electrodes; Humans; Hydrogen-Ion Concentration; Limit of Detection; Microscopy, Atomic Force; Molecular Imprinting; Polymers; Theobromine; Theophylline; Tin Compounds | 2016 |
Identifying the antiasthmatic target of doxofylline using immobilized β2 -adrenoceptor based high-performance affinity chromatography and site-directed molecular docking.
Topics: Animals; Anti-Asthmatic Agents; Binding Sites; Chromatography, Affinity; Hydrogen Bonding; Models, Molecular; Molecular Docking Simulation; Protein Binding; Receptors, Adrenergic, beta-2; Serine; Sus scrofa; Theophylline | 2016 |
Treatment plan comparison in acute and chronic respiratory tract diseases: an observational study of doxophylline vs. theophylline.
Topics: Acute Disease; Adrenal Cortex Hormones; Aged; Bronchodilator Agents; Chronic Disease; Drug Costs; Drug Monitoring; Female; Health Care Costs; Hospitalization; Humans; Italy; Male; Middle Aged; Respiratory Tract Diseases; Theophylline | 2017 |
Isolation and characterization of novel degradation products of Doxofylline using HPLC, FTIR, LCMS and NMR.
Topics: Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; Theophylline | 2017 |
Characterization of an unknown impurity in doxofylline using LC-MS and NMR.
Topics: Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Theophylline | 2017 |
Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect.
Topics: Anti-Inflammatory Agents; Bronchi; Bronchodilator Agents; Cells, Cultured; Cyclic AMP; Cyclohexanecarboxylic Acids; Dual Specificity Phosphatase 1; Formoterol Fumarate; Humans; Inflammation; Interleukin-8; Myocytes, Smooth Muscle; Nitriles; Phosphodiesterase Inhibitors; Theophylline; Tumor Necrosis Factor-alpha | 2017 |
A novel spectroscopic analysis to detect photochemical reaction of the bronchodilator - Doxofylline and its estimation in pharmaceutical formulation.
Topics: Analysis of Variance; Bronchodilator Agents; Calibration; Dosage Forms; Drug Compounding; Excipients; Photochemical Processes; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spectrum Analysis, Raman; Theophylline; Vibration | 2018 |
Steroid sparing effects of doxofylline.
Topics: Animals; Bronchodilator Agents; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Glucocorticoids; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Pneumonia; Theophylline | 2018 |
Comparison of anti-inflammatory mechanisms between doxofylline and theophylline in human monocytes.
Topics: Anti-Inflammatory Agents; Humans; Inflammation; Lipopolysaccharides; Monocytes; Protein Kinase C; Tetradecanoylphorbol Acetate; Theophylline | 2019 |
The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells.
Topics: Carrier Proteins; Cell Line; Dinoprostone; Epithelial Cells; Humans; Inflammasomes; Interleukin-18; Interleukin-1beta; Lipopolysaccharides; Mitochondria; NADPH Oxidases; Nitric Oxide; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Signal Transduction; Sirtuin 1; Theophylline | 2020 |
Biophysical insight into the binding mechanism of doxofylline to bovine serum albumin: An in vitro and in silico approach.
Topics: Binding Sites; Circular Dichroism; Molecular Docking Simulation; Protein Binding; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Thermodynamics | 2021 |
Effects of Doxofylline Combined with Ceftazidime on Clinical Efficacy, Drug Safety, and Prognosis in Patients with Chronic Obstructive Pulmonary Disease Complicated with Infection.
Topics: Aged; Ceftazidime; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Infections; Lung; Male; Middle Aged; Prognosis; Pulmonary Disease, Chronic Obstructive; Quality of Life; Theophylline; Treatment Outcome | 2021 |
Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease.
Topics: Animals; Lung; Male; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Theophylline; Tumor Necrosis Factor-alpha | 2021 |
Doxofylline Protects Gram-Negative Pathogens against Antibiotic-Mediated Killing.
Topics: Animals; Anti-Bacterial Agents; Membrane Transport Proteins; Mice; Microbial Sensitivity Tests; Theophylline | 2021 |
Effect of doxofylline on pulmonary inflammatory response and oxidative stress during mechanical ventilation in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammation; Interleukin-10; Male; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Random Allocation; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Theophylline; Tumor Necrosis Factor-alpha | 2022 |
Doxofylline in acute exacerbation of chronic obstructive pulmonary disease.
Topics: Disease Progression; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline | 2022 |