theophylline and diazepam

theophylline has been researched along with diazepam in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	44 (39.64)	18.7374
1990's	19 (17.12)	18.2507
2000's	17 (15.32)	29.6817
2010's	31 (27.93)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Coassolo, P; Lavé, T; Schneider, G	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Caron, G; Ermondi, G	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G	1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y	1
Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X	1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y	1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y	1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X	1
Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L	1
Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L	1
Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L	2
Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X	1
Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y	1
An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T	1
Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z	1
Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C	1
Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K	1
Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P	1
Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G	1
Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C	1
Badoual, J; Labrune, B; Tournier, G	1
Lehne, RA; Smith, PA; Weight, FF	1
Cohn, WM; Matthay, RA; Neff, TA; Sutton, FD; Weinberger, MM; Zwillich, CW	1
Nolte, D	2
Georgiev, V	1
Georgiev, V; Markovska, V	1
Georgiev, VP; Markovska, VL	1
Schwark, WS; Vancutsem, PM	1
Best, DJ; Griffiths, DA; Jezequel, SG	1
Humphries, TJ	1
Jorch, G; Rabe, H	1
Advenier, C; Blanc, M; Devillier, P; Gnassounou, JP	1
Connick, JH; Mally, J; Stone, TW	1
Dragunow, M	1
Gaitonde, CD; Pathak, PV	1
Holtzman, SG	1
De Mendonça, A; Ribeiro, JA	1
Daly, JW; Deckert, J; Jacobson, KA; Marangos, PJ; Morgan, PF	1
Nicholson, AN; Stone, BM	1
Hernández, J; Ribeiro, JA; Ruiz, F	1
Manresa, F	1
Jope, RS; Morrisett, RA; Snead, OC	1
Bulakhova, LA; Martyniuk, VIu	1
Daval, JL; Vert, P	1
Nordmann, H	1
Schultz, J	1
Beer, B; Chasin, M; Clody, DE; Vogel, JR	1
Bärmig, H; Rasche, P	1
Schindl, R	1
Diemath, HE; Enge, S; Lechner, H	1
Both, A	1
Pijoán de Beristain, C	1
Furukawa, T; Katsuragi, T; Ushijima, I	1
Harms, D; Nechvatal, D; Pachale, E	2
Phillis, JW; Wu, PH	1
Galloway, MP; Roth, RH	2
Boulenger, JP; Marangos, PJ; Patel, J	1
Barbaz, BS; Bergen, KM; Bernard, PS; Boast, CA	1
Barberis, C; Daval, JL; Vert, P	1
Mattila, MJ; Nuotto, E	1
Meyer, BH; Müller, FO; Weis, OF	1
Gillespie, HK; Henauer, SA; Hollister, LE; Moore, F	1
Brown, JW; Dean, LS	1
Lee, EK; Ross, RJ; Walters, JR; Waszczak, BL	1
Zenk, KE	1
Babb, RR	1
Doutlík, S; Hanzl, M; Pekárek, J; Rybnícek, A; Svejcar, J; Vacek, Z	1
Phillis JW Siemens, RK; Siemens, RK; Wu, PH	1
Gondo, K; Iwase, H; Koike, T; Ono, I	1
Simon, RP	1
Donat, J; Gerrard, JW; Richardson, JS	1
Bliesath, H; Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW; Wurst, W; Zech, K	1
Chapal, J; Loubatières-Mariani, MM; Manteghetti, M; Petit, P	1
Andersson, LI; Mosbach, K; Müller, R; Vlatakis, G	1
Ansell, RJ; Mosbach, K; Ramström, O	1
Leeuwin, RS; Van Wilgenburg, H; Zeegers, A	1
Gupta, YK; Malhotra, J	1
Fask, A; Saltiel, E	1
Yoshikawa, H	2
Gunawardhana, L; Lee, RD; Mulford, D; Vakily, M; Wu, J	1
Dordević, S; Jaćević, V; Jović-Stosić, J; Kilibarda, V; Potrebić, O; Segrt, Z; Vucinić, S; Vukcević-Perković, N	1
KuKanich, B; Nauss, JL	1

Reviews

5 review(s) available for theophylline and diazepam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole. Digestive diseases and sciences, 1991, Volume: 36, Issue:12 Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin	1991
The neuropharmacology of various diazepam antagonists. Neuropharmacology, 1983, Volume: 22, Issue:12B Topics: Animals; Benzodiazepinones; Caffeine; Carbolines; Diazepam; Flumazenil; Humans; Physostigmine; Pyrazoles; Receptors, Cell Surface; Receptors, GABA-A; Theophylline	1983
An overview of perinatal clinical pharmacology. Clinics in laboratory medicine, 1981, Volume: 1, Issue:2 Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digoxin; Female; Fetus; Furosemide; Gentamicins; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Penicillins; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Tetracycline; Theophylline	1981
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994

Trials

5 trial(s) available for theophylline and diazepam

Article	Year
[Vigilance and beta blockade. The influence of the beta blocker atenolol and other substances on the reaction time of the visual system]. Fortschritte der Medizin, 1981, Mar-05, Volume: 99, Issue:9 Topics: Adrenergic beta-Antagonists; Adult; Amphetamines; Atenolol; Attention; Diazepam; Humans; Male; Oxazepam; Propanolamines; Reaction Time; Theophylline; Visual Perception	1981
Influence of the beta-blocking atenolol and other medications on visual reaction time. Aviation, space, and environmental medicine, 1981, Volume: 52, Issue:11 Pt 2 Topics: Adult; Amphetamines; Atenolol; Central Nervous System Stimulants; Diazepam; Drug Interactions; Ethanol; Humans; Male; Oxazepam; Propanolamines; Reaction Time; Theophylline; Time Factors; Vision, Ocular	1981
Caffeine and theophylline counteract diazepam effects in man. Medical biology, 1983, Volume: 61, Issue:6 Topics: Adult; Caffeine; Clinical Trials as Topic; Cognition; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Antagonism; Female; Flicker Fusion; Humans; Male; Psychomotor Performance; Theophylline	1983
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994
Drug interaction studies with dexlansoprazole modified release (TAK-390MR), a proton pump inhibitor with a dual delayed-release formulation: results of four randomized, double-blind, crossover, placebo-controlled, single-centre studies. Clinical drug investigation, 2009, Volume: 29, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anticoagulants; Anticonvulsants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bronchodilator Agents; Cross-Over Studies; Delayed-Action Preparations; Dexlansoprazole; Diazepam; Double-Blind Method; Drug Interactions; Female; Humans; Lansoprazole; Male; Middle Aged; Phenytoin; Proton Pump Inhibitors; Theophylline; Warfarin; Young Adult	2009

Other Studies

102 other study(ies) available for theophylline and diazepam

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats	1999
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats	2015
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2016, 05-15, Volume: 24, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine	2016
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties. Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2 Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship	2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2017, Jan-27, Volume: 126 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats	2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine	2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary	2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry, 2017, 03-15, Volume: 25, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones	2017
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats	2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2017, 06-15, Volume: 25, Issue:12 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine	2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2017, 11-15, Volume: 27, Issue:22 Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship	2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2017, 11-15, Volume: 27, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship	2017
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. Bioorganic & medicinal chemistry, 2018, 03-01, Volume: 26, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship	2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry, 2018, 05-01, Volume: 26, Issue:8 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles	2018
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold. Bioorganic & medicinal chemistry letters, 2018, 06-15, Volume: 28, Issue:11 Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship	2018
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2018, 12-15, Volume: 26, Issue:23-24 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship	2018
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities. Bioorganic & medicinal chemistry, 2019, 03-15, Volume: 27, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine	2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2019, Sep-15, Volume: 178 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship	2019
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates	2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship	2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry, 2019, Dec-01, Volume: 183 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship	2019
[Pediatrics in 1979]. La Revue du praticien, 1979, Mar-21, Volume: 29, Issue:17 Topics: Abdominal Neoplasms; Age Factors; Asthma; Child; Child, Preschool; Cryptorchidism; Diazepam; Goiter; Hepatitis, Viral, Human; Humans; Hypothyroidism; Infant; Infant, Newborn; Lymphatic Diseases; Male; Measles; Meningitis, Haemophilus; Pediatrics; Theophylline	1979
Potentiation of Ca2+-dependent K+ activation by theophylline is independent of cyclic nucleotide elevation. Nature, 1979, Aug-02, Volume: 280, Issue:5721 Topics: Action Potentials; Animals; Anura; Bucladesine; Calcium; Diazepam; Dibutyryl Cyclic GMP; Methacholine Compounds; Nucleotides, Cyclic; Papaverine; Potassium; Rana catesbeiana; Sympathetic Nervous System; Theophylline	1979
Theophylline-induced seizures in adults. Correlation with serum concentrations. Annals of internal medicine, 1975, Volume: 82, Issue:6 Topics: Adult; Aged; Creatinine; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Kidney; Liver; Male; Middle Aged; Nitrogen; Phenobarbital; Phenytoin; Seizures; Theophylline; Urea	1975
[Acute dyspnea]. Medizinische Klinik, 1978, Jun-16, Volume: 73, Issue:24 Topics: Adrenal Cortex Hormones; Airway Obstruction; Anti-Arrhythmia Agents; Asthma; Diagnosis, Differential; Diazepam; Diuretics; Dyspnea; Epinephrine; Pleural Effusion; Pneumothorax; Pulmonary Atelectasis; Pulmonary Edema; Respiration, Artificial; Theophylline	1978
[Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam]. Eksperimentalna meditsina i morfologiia, 1978, Volume: 17, Issue:3 Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; gamma-Aminobutyric Acid; Imidazoles; Male; Mice; Papaverine; Picrotoxin; Seizures; Theophylline; Time Factors	1978
Effects of apomorphine, pimoside, theophylline, meta-tolylcarbamide and diazepam on the picrotoxin convulsive-seizure threshold. Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles, 1976, Volume: 29, Issue:11 Topics: Animals; Apomorphine; Brain; Diazepam; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Seizures; Theophylline	1976
Are the central dopaminergic synapses related to the convulsive-seizure threshold?--Effects of central dopaminergic drugs on the picrotoxin convulsive-seizure threshold. Interaction with diazepam, meta-tolylcarbamide and theophylline. Acta physiologica et pharmacologica Bulgarica, 1976, Volume: 2, Issue:4 Topics: Animals; Apomorphine; Diazepam; Drug Interactions; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Receptors, Dopamine; Seizures; Theophylline	1976
Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. Epilepsy research, 1992, Volume: 13, Issue:1 Topics: 2-Chloroadenosine; Amygdala; Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Enrofloxacin; Female; Fluoroquinolones; Kindling, Neurologic; Norfloxacin; Quinolones; Rats; Rats, Sprague-Dawley; Seizures; Theophylline	1992
The screening of selected microorganisms for use as models of mammalian drug metabolism. Applied microbiology and biotechnology, 1991, Volume: 35, Issue:3 Topics: Animals; Diazepam; Fungi; In Vitro Techniques; Male; Microsomes, Liver; Models, Biological; Pharmaceutical Preparations; Rats; Streptomyces; Testosterone; Theophylline; Warfarin	1991
Cerebral hemodynamics in perinatal pharmacology. Developmental pharmacology and therapeutics, 1991, Volume: 17, Issue:3-4 Topics: Cerebrovascular Circulation; Diazepam; Humans; Infant, Newborn; Infant, Premature; Meperidine; Pancuronium; Phenobarbital; Surface-Active Agents; Theophylline; Ultrasonics	1991
Peripheral type benzodiazepine receptors and response to adenosine on the guinea-pig isolated trachea. Pulmonary pharmacology, 1990, Volume: 3, Issue:3 Topics: Adenosine; Animals; Benzodiazepines; Clonazepam; Diazepam; Dipyridamole; Drug Synergism; GABA-A Receptor Antagonists; Guinea Pigs; Histamine; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Receptors, GABA-A; Theophylline; Trachea	1990
Chronic benzodiazepine treatment and cortical responses to adenosine and GABA. Brain research, 1990, Oct-22, Volume: 530, Issue:2 Topics: Adenosine; Animals; Anti-Anxiety Agents; Cerebral Cortex; Clonazepam; Diazepam; Electrodes; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; N-Methylaspartate; Serotonin; Theophylline	1990
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4 Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines	1990
Estimation of the analgesic muscle relaxants chlorzoxazone and diazepam in human plasma by reversed-phase liquid chromatography. Journal of chromatography, 1990, Jun-29, Volume: 528, Issue:2 Topics: Acetaminophen; Analgesics; Benzoxazoles; Chlorzoxazone; Chromatography; Diazepam; Humans; Muscle Relaxants, Central; Oxyphenbutazone; Theophylline	1990
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline	1986
Diazepam enhances the inhibitory action of adenosine on transmission at the frog neuromuscular junction. European journal of pharmacology, 1989, May-19, Volume: 164, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Diazepam; Dipyridamole; Drug Synergism; In Vitro Techniques; Membrane Potentials; Motor Endplate; Muscle Contraction; Neuromuscular Junction; Rana ridibunda; Synaptic Transmission; Theophylline	1989
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC). Life sciences, 1989, Volume: 45, Issue:8 Topics: Animals; Caffeine; Convulsants; Diazepam; Dipyridamole; Male; Mice; Purinergic Antagonists; Random Allocation; Seizures; Theophylline; Xanthines	1989
Antihistamines: impaired performance and the tendency to sleep. European journal of clinical pharmacology, 1986, Volume: 30, Issue:1 Topics: Adult; Benzhydryl Compounds; Diazepam; Female; Flicker Fusion; Histamine Antagonists; Humans; Psychomotor Performance; Sleep; Terfenadine; Theophylline; Triprolidine; Visual Acuity	1986
Theophylline antagonizes the effect of diazepam on ventricular automaticity. European journal of pharmacology, 1988, Oct-18, Volume: 155, Issue:3 Topics: Adenosine; Animals; Diazepam; Female; Flumazenil; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Theophylline; Ventricular Function	1988
Should symptoms--namely cough and dyspnoea--be treated? European journal of respiratory diseases. Supplement, 1986, Volume: 146 Topics: Codeine; Cough; Diazepam; Dyspnea; Ethanol; Humans; Oxygen Inhalation Therapy; Promethazine; Theophylline	1986
Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Experimental neurology, 1987, Volume: 97, Issue:1 Topics: Animals; Anticonvulsants; Atropine; Diazepam; Electroencephalography; Lithium; Male; Paraldehyde; Phenylisopropyladenosine; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus; Theophylline	1987
[Value of complamin and seduxen in the correction of hemodynamic disorders of epileptic children and adolescents]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1987, Volume: 87, Issue:6 Topics: Adolescent; Anticonvulsants; Brain; Cerebrovascular Disorders; Child; Diazepam; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Plethysmography, Impedance; Regional Blood Flow; Theophylline; Xanthinol Niacinate; Xenon Radioisotopes	1987
Effect of chronic exposure to methylxanthines on diazepam cerebral binding in female rats and their offsprings. Brain research, 1986, Volume: 392, Issue:1-2 Topics: Animals; Brain; Caffeine; Diazepam; Female; Lactation; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Synaptosomes; Theophylline	1986
Grip strength test and infrared thermometry as non-invasive methods to complement acute toxicity data in mice. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1985, Volume: 8 Topics: Animals; Calorimetry; Diazepam; Dose-Response Relationship, Drug; Mice; Muscle Contraction; Pentobarbital; Theophylline	1985
Inhibition of phosphodiesterase activity in brain cortical slices from guinea pig and rat. Pharmacological research communications, 1974, Volume: 6, Issue:4 Topics: Adenosine; Animals; Benzyl Compounds; Cerebral Cortex; Chlordiazepoxide; Cyclic AMP; Diazepam; Ethers; Guinea Pigs; Histamine; Hydrazines; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Norepinephrine; Oxazepam; Phosphodiesterase Inhibitors; Pyrazoles; Pyridines; Rats; Species Specificity; Theophylline	1974
Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety. Science (New York, N.Y.), 1972, Apr-28, Volume: 176, Issue:4033 Topics: Animals; Anxiety; Barbiturates; Brain; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Cyclic AMP; Diazepam; Humans; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Punishment; Rats; Theobromine; Theophylline; Tranquilizing Agents	1972
[Atypical course in postpartum eclampsia? A case report]. Zentralblatt fur Gynakologie, 1972, Dec-02, Volume: 94, Issue:48 Topics: Adult; Chlorpromazine; Diazepam; Eclampsia; Female; Humans; Hypertension; Infant, Newborn; Infant, Premature; Ischemic Attack, Transient; Nicotinic Acids; Pregnancy; Pressure Ulcer; Promethazine; Puerperal Disorders; Theophylline; Twins	1972
[Therapy and mortality in status asthmaticus]. Munchener medizinische Wochenschrift (1950), 1972, Aug-25, Volume: 114, Issue:34 Topics: Adrenal Cortex Hormones; Age Factors; Aged; Asphyxia; Asthma; Austria; Diazepam; Female; Humans; Intensive Care Units; Male; Middle Aged; Physical Therapy Modalities; Respiratory Insufficiency; Respiratory Tract Infections; Theophylline	1972
EEG depth leads during stereotaxic brain surgery. A report on 117 cases (5 target points, effects of 13 different drugs). Confinia neurologica, 1970, Volume: 32, Issue:2 Topics: Amides; Amygdala; Antimetabolites; Asparagine; Benzoates; Brain; Brain Diseases; Cerebrovascular Circulation; Child; Chlordiazepoxide; Diazepam; Dihydroxyphenylalanine; Electroencephalography; Female; Fluphenazine; Gyrus Cinguli; Hippocampus; Humans; Hyperkinesis; Male; Methanol; Middle Aged; Parkinson Disease; Pyridines; Pyridoxine; Spasm; Stereotaxic Techniques; Thalamic Nuclei; Theophylline; Tranquilizing Agents; Triflupromazine; Vasodilator Agents	1970
[Therapy of primary pulmonary hypertension]. Zeitschrift fur Kreislaufforschung, 1970, Volume: 59, Issue:10 Topics: Acetylcholine; Amino Alcohols; Carbachol; Child; Diazepam; Diazoxide; Female; Humans; Hypertension, Pulmonary; Isoproterenol; Isosorbide Dinitrate; Neostigmine; Nitroglycerin; Pentaerythritol Tetranitrate; Rest; Theophylline; Tolazoline; Verapamil	1970
[Therapeutic tests of a preparation with a base of theophylline glycinate and nitrodiazepan]. Revista espanola de cardiologia, 1968, Volume: 21, Issue:3 Topics: Diazepam; Heart Failure; Humans; Suppositories; Theophylline	1968
Involvement of adenosine receptor activities in aggressive responses produced by clonidine in mice. Psychopharmacology, 1984, Volume: 83, Issue:4 Topics: Adenosine; Aggression; Animals; Apomorphine; Bicuculline; Clonidine; Diazepam; Dipyridamole; Humans; Male; Mice; Receptors, Cell Surface; Receptors, Purinergic; Theophylline	1984
Adenosine mediates sedative action of various centrally active drugs. Medical hypotheses, 1982, Volume: 9, Issue:4 Topics: Adenosine; Animals; Antipsychotic Agents; Arousal; Brain; Caffeine; Diazepam; Hypnotics and Sedatives; Phenothiazines; Rats; Receptors, Cell Surface; Receptors, Purinergic; Synapses; Synaptic Transmission; Synaptosomes; Theophylline	1982
Clonidine prevents methylxanthine stimulation of norepinephrine metabolism in rat brain. Journal of neurochemistry, 1983, Volume: 40, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Brain; Cerebellum; Clonidine; Diazepam; Hippocampus; Kinetics; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline	1983
Neuropharmacology of 3-isobutylmethylxanthine: effects on central noradrenergic systems in vivo. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Axons; Brain; Clonidine; Diazepam; Dihydroxyphenylalanine; Hydroxylation; Male; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Tyrosine 3-Monooxygenase; Yohimbine	1983
Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain. Neuroscience letters, 1982, May-28, Volume: 30, Issue:2 Topics: Adenosine; Binding, Competitive; Brain; Caffeine; Diazepam; Humans; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Purinergic; Theophylline; Xanthines	1982
In vitro and in vivo displacement of [3H]-diazepam binding by purine derivatives in developing rat brain. Developmental pharmacology and therapeutics, 1984, Volume: 7, Issue:3 Topics: Animals; Binding, Competitive; Brain; Caffeine; Diazepam; Female; In Vitro Techniques; Kinetics; Male; Membranes; Pregnancy; Purines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Theophylline	1984
Antagonism of diazepam by aminophylline in healthy volunteers. Anesthesia and analgesia, 1984, Volume: 63, Issue:10 Topics: Aminophylline; Arousal; Diazepam; Double-Blind Method; Flicker Fusion; Humans; Male; Random Allocation; Reaction Time; Theophylline	1984
Theophylline antagonizes diazepam-induced psychomotor impairment. European journal of clinical pharmacology, 1983, Volume: 25, Issue:6 Topics: Administration, Oral; Adult; Anxiety; Diazepam; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Psychomotor Performance; Theophylline	1983
Massive theophylline overdose. Survival without hemoperfusion. JAMA, 1982, Oct-08, Volume: 248, Issue:14 Topics: Bronchodilator Agents; Choline; Diazepam; Epilepsy, Tonic-Clonic; Female; Hemoperfusion; Humans; Middle Aged; Theophylline	1982
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata. Life sciences, 1982, Sep-06, Volume: 31, Issue:10 Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline	1982
[Dyspnea--what is to be done?]. Wiener medizinische Wochenschrift (1946), 1982, Apr-30, Volume: 132, Issue:8 Topics: Diazepam; Digoxin; Diuretics; Dyspnea; Emergencies; Epinephrine; Glucocorticoids; Humans; Lidocaine; Myocardial Infarction; Nitrates; Pulmonary Edema; Theophylline	1982
Drug interactions with cimetidine. Postgraduate medicine, 1981, Volume: 70, Issue:5 Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin	1981
[Drug-controlled macrophage migration inhibition test (author's transl)]. Casopis lekaru ceskych, 1980, Volume: 119, Issue:11 Topics: Cell Migration Inhibition; Chlorpromazine; Diazepam; Humans; Macrophages; Meperidine; Theophylline	1980
Effects of diazepam on adenosine and acetylcholine release from rat cerebral cortex: further evidence for a purinergic mechanism in action of diazepam. British journal of pharmacology, 1980, Volume: 70, Issue:2 Topics: Acetylcholine; Adenosine; Animals; Brain; Diazepam; Male; Pentobarbital; Purines; Rats; Theophylline	1980
Novel precolumn deproteinization method using a hydroxyapatite cartridge for the determination of theophylline and diazepam in human plasma by high-performance liquid chromatography with ultraviolet detection. Journal of chromatography. B, Biomedical applications, 1994, Apr-22, Volume: 655, Issue:1 Topics: Albumins; Chromatography, High Pressure Liquid; Diazepam; gamma-Globulins; Humans; Hydrogen-Ion Concentration; Hydroxyapatites; Indicators and Reagents; Spectrophotometry, Ultraviolet; Theophylline; Transferrin	1994
Defusing status epilepticus. Hospital practice (Office ed.), 1995, Apr-15, Volume: 30, Issue:4 Topics: Blood Gas Analysis; Body Temperature; Diazepam; Humans; Infusions, Intravenous; Lung Diseases, Obstructive; Male; Middle Aged; Phenytoin; Rectum; Status Epilepticus; Theophylline	1995
Neuropharmacological evaluation of movement disorders that are adverse reactions to specific foods. The International journal of neuroscience, 1994, Volume: 76, Issue:1-2 Topics: Adult; Animals; Aspartame; Carbidopa; Coffee; Diazepam; Double-Blind Method; Eggs; Female; Food Hypersensitivity; Haloperidol; Humans; Male; Milk; Milk Hypersensitivity; Movement Disorders; Propranolol; Single-Blind Method; Theophylline; Videotape Recording	1994
[Research of the mechanism of the inhibition of insulin secretion induced by a peripheral benzodiazepine: 4'-chlordiazepam]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1993, Volume: 187, Issue:4 Topics: Animals; Bucladesine; Colforsin; Convulsants; Diazepam; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Theophylline	1993
Drug assay using antibody mimics made by molecular imprinting. Nature, 1993, Feb-18, Volume: 361, Issue:6413 Topics: Antibodies; Binding Sites, Antibody; Binding, Competitive; Cross-Linking Reagents; Diazepam; Humans; Methacrylates; Microchemistry; Polymers; Theophylline	1993
Towards artificial antibodies prepared by molecular imprinting. Clinical chemistry, 1996, Volume: 42, Issue:9 Topics: Antibodies; Atrazine; Binding, Competitive; Corticosterone; Cross Reactions; Diazepam; Enkephalin, Leucine; Enzyme-Linked Immunosorbent Assay; Humans; Hydrocortisone; Kinetics; Methylglucosides; Molecular Mimicry; Morphine; Polymers; Propranolol; Radioimmunoassay; Stereoisomerism; Theophylline; Yohimbine	1996
Flunarizine but not theophylline modulates inotropic responses of the isolated rat heart to diazepam. European journal of pharmacology, 1996, Nov-14, Volume: 315, Issue:2 Topics: Animals; Anti-Anxiety Agents; Calcium Channel Blockers; Diazepam; Female; Flunarizine; Myocardial Contraction; Rats; Rats, Wistar; Theophylline; Vasodilator Agents	1996
Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. Indian journal of physiology and pharmacology, 1997, Volume: 41, Issue:3 Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Interactions; Male; Pentylenetetrazole; Protective Agents; Rats; Rats, Wistar; Seizures; Theophylline; Valproic Acid	1997
Prevalence of potential proton-pump inhibitor drug interactions: a retrospective review of prescriptions in community pharmacies. Clinical therapeutics, 1999, Volume: 21, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Diazepam; Drug Interactions; Enzyme Inhibitors; Humans; Lansoprazole; Omeprazole; Pharmacies; Prevalence; Proton Pump Inhibitors; Retrospective Studies; Theophylline; Warfarin	1999
First-line therapy for theophylline-associated seizures. Acta neurologica Scandinavica. Supplementum, 2007, Volume: 186 Topics: Age of Onset; Animals; Anticonvulsants; Barbiturates; Brain Damage, Chronic; Child; Child, Preschool; Diazepam; Drug Interactions; Emergency Medical Services; Female; Humans; Infant; Injections, Intravenous; Male; Mice; Seizures; Status Epilepticus; Theophylline; Time Factors	2007
[Treatment for seizures during theophylline medication]. No to hattatsu = Brain and development, 2008, Volume: 40, Issue:2 Topics: Anticonvulsants; Barbiturates; Bronchodilator Agents; Child, Preschool; Diazepam; Drug Resistance; Humans; Seizures; Theophylline	2008
[Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam]. Vojnosanitetski pregled, 2009, Volume: 66, Issue:2 Topics: Animals; Antidotes; Diazepam; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Male; Motor Activity; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Theophylline	2009
Pharmacokinetics of the cytochrome P-450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs. Journal of veterinary pharmacology and therapeutics, 2012, Volume: 35, Issue:3 Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diazepam; Dogs; Female; Fluorescence Polarization Immunoassay; Gas Chromatography-Mass Spectrometry; Injections, Intravenous; Male; Nordazepam; Oxazepam; Phenytoin; Theophylline	2012