theophylline and dextromethorphan

theophylline has been researched along with dextromethorphan in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's2 (14.29)18.2507
2000's1 (7.14)29.6817
2010's10 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Levy, G; Zhi, JG1
Beresford, TP; Coleman, JH; Hall, RC; Nasdahl, CS; Stickney, SK1
Amabeoku, GJ1
Bramer, SL; Brisson, J; Kitani, M; Miyamoto, G; Tammara, B; Trang, JM1
Acharya, M; Bernard, A; Chi, KN; Jiao, J; Kaiser, B; Kollmannsberger, CK; Lee, P; Molina, A; Pankras, C; Papadopoulos, KP; Patnaik, A; Rosen, PJ; Tolcher, A; Tran, N1
Isoherranen, N; Ke, AB; Nallani, SC; Rostami-Hodjegan, A; Unadkat, JD; Zhao, P1
Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM1
Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ1
Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ1
Donovan, MD; Meruva, S1
Chiang, W; Li, ML; Lin, JH; Liu, YT; Yao, HT1

Reviews

2 review(s) available for theophylline and dextromethorphan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Psychiatric reactions produced by respiratory drugs.
    Psychosomatics, 1985, Volume: 26, Issue:7

    Topics: Adolescent; Adult; Albuterol; Bronchodilator Agents; Calcium Channel Blockers; Child; Cromolyn Sodium; Dextromethorphan; Ephedrine; Expectorants; Humans; Iodides; Mental Disorders; Nasal Decongestants; Parasympatholytics; Phenylpropanolamine; Psychoses, Substance-Induced; Theophylline

1985

Trials

3 trial(s) available for theophylline and dextromethorphan

ArticleYear
The effects of concomitant administration of theophylline and toborinone on the pharmacokinetics of both compounds in poor and extensive metabolizers via CYP2D6.
    Journal of clinical pharmacology, 2002, Volume: 42, Issue:5

    Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Drug Interactions; Humans; Quinolones; Theophylline; Vasodilator Agents

2002
Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer.
    Cancer chemotherapy and pharmacology, 2013, Volume: 71, Issue:1

    Topics: Abiraterone Acetate; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Dextromethorphan; Drug Interactions; Follow-Up Studies; Humans; Male; Neoplasm Metastasis; Prednisone; Prostatic Neoplasms; Theophylline

2013
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
    Journal of clinical pharmacology, 2014, Volume: 54, Issue:4

    Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult

2014

Other Studies

9 other study(ies) available for theophylline and dextromethorphan

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats.
    Journal of pharmaceutical sciences, 1990, Volume: 79, Issue:12

    Topics: Administration, Oral; Animals; Dextromethorphan; Female; Pentylenetetrazole; Premedication; Rats; Rats, Inbred Lew; Seizures; Theophylline

1990
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
    General pharmacology, 1999, Volume: 32, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Clonidine; Dextromethorphan; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ketamine; Mice; Muscimol; N-Methylaspartate; Picrotoxin; Receptors, GABA; Receptors, Glutamate; Seizures; Theophylline

1999
A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

    Topics: Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Female; Humans; Models, Biological; Paroxetine; Pregnancy; Theophylline

2013
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:3

    Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide

2015
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2017, Volume: 52, Issue:2

    Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency

2017
Effects of Drug-Polymer Interactions on Tablet Properties During the Development of Abuse-Deterrent Dosage Forms.
    AAPS PharmSciTech, 2019, Jan-28, Volume: 20, Issue:3

    Topics: Delayed-Action Preparations; Dextromethorphan; Dosage Forms; Ketoprofen; Polyethylene Glycols; Promethazine; Solubility; Substance-Related Disorders; Tablets; Theophylline

2019
Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats.
    Nutrients, 2019, Oct-15, Volume: 11, Issue:10

    Topics: Administration, Intravenous; Administration, Oral; Animals; Capsaicin; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Diltiazem; Food-Drug Interactions; Intestinal Absorption; Intestines; Liver; Male; Plant Oils; Rats, Sprague-Dawley; Risk Assessment; Theophylline

2019