theophylline has been researched along with cycloheximide in 143 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 134 (93.71) | 18.7374 |
1990's | 6 (4.20) | 18.2507 |
2000's | 3 (2.10) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Connolly, DT; Oppenheimer, SB | 1 |
DeLap, L; Ernest, MJ; Feigelson, P | 1 |
Losier, AJ; YoungLai, EV | 1 |
Huberman, E; Sachs, L; Yamasaki, H | 1 |
Berv, KR; Kopin, IJ; Webb, JG | 1 |
Kowle, RL; Sallach, HJ; Sanborn, TA | 1 |
Younglai, EV | 1 |
Oka, T; Perry, JW | 1 |
Karelin, AA; Mardashev, SR | 1 |
Kapoor, HC; Sachar, RC | 1 |
Moore, EG | 1 |
LaMont, JT; Ventola, A | 1 |
Edkins, E; Rïhä, NC | 1 |
Attallah, AM; Houck, JC | 1 |
Mazière, C; Mazière, JC; Polonovski, J | 1 |
Alford, BL; Barnes, EM | 1 |
Hirobe, T; Takeuchi, T | 1 |
Allende, CC; Allende, JE; Bravo, R; Otero, C | 1 |
Hosokawa, Y; Kohashi, N; Kori, Y; Ueda, I; Yamaguchi, K | 1 |
Arinze, IJ; Raghunathan, R; Russell, JD | 1 |
Dillmann, WH; Oppenheimer, JH | 1 |
Hays, EF; Ramsey, R | 1 |
Eigel, WN; Keenan, TW; Park, CS; Smith, JJ | 1 |
Bhargava, HN; Ho, LK; Loh, HH; Way, EL | 1 |
Carlisle, KS; Hersey, SJ; Reagan, CR | 1 |
O'Connor, CM; Robinson, KR; Smith, LD | 1 |
Ashby, P; Bennett, DP; Robinson, DS; Spencer, IM | 1 |
Allewell, NM; Oles, J; Wolfe, J | 1 |
Steinberg, ML; Whittaker, JR | 1 |
Frei, E; Wick, MM | 1 |
Boksay, I; Csanyi, V; Gervai, J; Lajtha, A | 1 |
Gorkin, VZ; Gridneva, LI; Repiakh, LG; Suvorov, NN | 1 |
Bang, YJ; Danielpour, D; Kim, KY; Kim, SJ; Myers, CE; O'Reilly, MA; Trepel, JB | 1 |
Fitzgerald, TJ; Goorha, RM; Neale, GA | 1 |
Kummel, L; Pilkis, SJ | 1 |
Claudio, T; Green, WN; Ross, AF | 1 |
Kulomaa, MS; Niemelä, AO; Tuohimaa, PJ | 1 |
Adachi, S; Nagahama, Y; Tan, JD | 1 |
Olashaw, NE; Pledger, WJ | 1 |
Dasarathy, Y; Fanburg, BL | 1 |
Buchou, T; Charollais, RH; Fagot, D; Mester, J | 1 |
Baxter, RC; Lewitt, MS | 1 |
Perez-Polo, JR; Shen, RS; Zhang, YX | 1 |
Marakhova, II; Vinogradova, TA; Yefimova, EV | 1 |
Babey, AM; Palmour, RM; Smith, AJ | 1 |
Onagbesan, OM; Peddie, MJ | 1 |
Cánepa, ET; Grinstein, M; Llambías, EB | 1 |
Bersimbaev, RI; Salganik, RI; Tairov, MM | 1 |
Wong, SS; Woo, PT | 1 |
Al-Jafari, AA; Cryer, A | 1 |
Bantle, JA; Dawson, DA | 1 |
Higashida, H; Kato, K; Sano, M | 1 |
Singhal, RL | 1 |
Kato, R; Koyama, H; Ono, T | 1 |
Parulekar, MR; Robison, GA; Singhal, RL; Vijayvargiya, R | 1 |
Lafreniere, RT; Singhal, RL | 1 |
Argutinskaya, SV; Bersimbaev, RI; Salganik, RI | 1 |
Lavis, VR; Williams, RH | 1 |
Edström, A; Kanje, M; Walum, E | 1 |
Forstner, G; Lukie, B; Shih, M | 1 |
Räihä, NC; Schwartz, AL | 1 |
Passonneau, JV; Schwartz, JP | 1 |
Kikuchi, G; Kim, HJ | 1 |
Mackay, AV | 1 |
Arlett, CF | 1 |
Goodman, HM | 1 |
Vaughan, M | 1 |
Fain, JN; Moskowitz, J | 1 |
Fain, JN | 1 |
Lafreniere, R; Singhal, RL | 1 |
Dodd, A; Fain, JN; Novak, L | 1 |
Bottomley, SS; Moore, MA; Smithee, GA; Whitcomb, WH | 1 |
Berg, GR; Klein, DC | 2 |
Cox, RP | 1 |
Caldwell, AB; Fain, JN | 1 |
Jungmann, RA; Leier, DJ | 2 |
Buneaux, JJ; Gounelle, JC; Raoul, Y | 1 |
Raisz, LG; Simmons, H; Trummel, CL | 1 |
Fayet, G; Giraud, A; Lissitzky, S; Torresani, J; Verrier, B | 1 |
D'Armiento, M; Johnson, GS; Pastan, I | 1 |
Forn, J; Gessa, GL; Tagliamonte, A; Tagliamonte, P | 1 |
Prasad, KN; Sheppard, JR | 1 |
Dianzani, F; Neri, P; Zucca, M | 1 |
Davies, NT; Munday, KA; Parsons, BJ | 1 |
Downing, SJ; Phang, JM | 1 |
Kumar, S; Prasad, KN | 1 |
Hermier, C; Jutisz, M; Netter, A; Santos, AA; Wisnewsky, C | 1 |
Kram, R; Mamont, P; Tomkins, GM | 1 |
Das, KC; Hoffbrand, AV; Tripp, E | 1 |
Kram, R; Tomkins, GM | 1 |
Feigelson, M | 1 |
Hölttä, E; Raina, A | 1 |
Boyd, GS; Trzeciak, WH | 2 |
Castor, CW | 1 |
Boyle, JM; Gardner, JD | 1 |
Bernard, EA; Engel, JC; Wassermann, GF | 1 |
van der Plaat, JB | 1 |
Räihä, NC; Rall, TW; Schwartz, AL | 1 |
Katsuta, H; Nose, K | 1 |
Laron, Z; Silbergeld, AK | 1 |
Jimenez de Asua, L; Rozengurt, E | 1 |
Schwartz, A | 1 |
Hussa, RO; Pattillo, RA; Story, MT | 1 |
Asami, K; Furuno, I; Matsudaira, H | 1 |
Feldman, JF; Thayer, JP | 1 |
Wicks, WD | 1 |
Matsukura, S | 1 |
Nakashima, Y; Sanada, H; Suzue, R | 1 |
Axelrod, J; Deguchi, T | 1 |
Iversen, LL; Mackay, AV | 1 |
Morley, CG | 1 |
Green, IC; Howell, SL; Montague, W | 1 |
Oravec, M; Sourkes, TL; Young, SN | 1 |
Ramasarma, T; Sitaramam, V | 1 |
Kurahashi, M | 1 |
McKean, CM; Peterson, NA; Raghupathy, E | 1 |
Crowther, R; Fleming, N; Forstner, J; Laburthe, M; Roomi, N | 1 |
Schaffner, CP; Singhal, AK | 1 |
Epstein, PM; Hersh, EM; Ross, CP; Strada, SJ; Thompson, WJ | 1 |
Marks, F | 1 |
Knightbridge, A; Ralph, RK | 1 |
Ali, NN; Chambers, TJ | 1 |
Hechtman, HB; Schleef, R; Shepro, D | 1 |
Grotendorst, GR; Schimmel, SD | 1 |
Kako, T; Tanaka, M | 1 |
Savage, CR; Smith, CM | 1 |
Kline, EL; Montefiori, DC | 1 |
de Koning, J; Tijssen, AM; van Dieten, JA; van Rees, GP | 2 |
Bellino, FL; Hussa, RO | 1 |
Farese, RV; Larson, RE; Sabir, MA | 1 |
Fernandez, CS; McCoshen, JA; Tomita, K; Tyson, JE | 1 |
Patole, MS; Puranam, RS; Ramasarma, T; Swaroop, A | 1 |
Saga, K; Shimojo, T | 1 |
Malaisse, WJ; Sener, A | 1 |
Cundiff, DL; Soff, GA; Traynor, AE | 1 |
Jantzen, H; Schulze, I | 1 |
Brenner, RR; Finarelli, GS; Rimoldi, OJ | 1 |
143 other study(ies) available for theophylline and cycloheximide
Article | Year |
---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cell density-dependent stimulation of glutamine synthetase activity in cultured mouse teratoma cells.
Topics: Bucladesine; Cell Count; Cell Division; Cells, Cultured; Culture Media; Cycloheximide; Dactinomycin; Glutamate-Ammonia Ligase; Glutamine; Hydrocortisone; Theophylline | 1975 |
Induction of hepatic tyrosine aminotransferase mRNA by protein synthesis inhibitors.
Topics: Animals; Bucladesine; Cyclic AMP; Cycloheximide; Emetine; Hydrocortisone; Liver; Male; Puromycin; Rats; RNA, Messenger; Theophylline; Transcription, Genetic; Tyrosine Transaminase | 1978 |
Molecular control of rabbit follicular testosterone production: role of cyclic AMP and cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Female; Ovary; Protein Biosynthesis; Puromycin; Rabbits; RNA; Testosterone; Theophylline | 1979 |
Regulation of aryl hydrocarbon (benzo-(A)-pyrene) hydroxylase activity in mammalian cells. Induction of hydroxylase activity by N6,O2'-dibutyryl8 adenosine 3':5'-monophosphate and aminophylline.
Topics: Aminophylline; Benzopyrene Hydroxylase; Bucladesine; Cell Line; Cyclic AMP; Cyclic GMP; Cycloheximide; Enzyme Induction; Kinetics; Mixed Function Oxygenases; Papaverine; Theophylline | 1975 |
Induction of dopamine-beta-hydroxylase in superior cervical ganglia in organ culture.
Topics: Adenylyl Cyclases; Animals; Bucladesine; Cyclic AMP; Cycloheximide; Dopamine beta-Hydroxylase; Enzyme Induction; Ganglia, Spinal; L-Lactate Dehydrogenase; Male; Monoamine Oxidase; Nerve Tissue Proteins; Organ Culture Techniques; Potassium; Rats; Theophylline | 1975 |
Regulation of enzymes of serine and one-carbon metabolism by testosterone in rat prostate, liver, and kidney.
Topics: Alcohol Oxidoreductases; Animals; Bucladesine; Carbohydrate Dehydrogenases; Castration; Cycloheximide; Drug Interactions; Glycine Hydroxymethyltransferase; Kidney; Liver; Male; Phosphoric Monoester Hydrolases; Prostate; Rats; Serine; Testosterone; Theophylline; Transferases | 1975 |
Steroid production by the isolated rabbit ovarian follicle.
Topics: Adenosine Monophosphate; Androgens; Animals; Bucladesine; Cyclic AMP; Cycloheximide; Cytosine Nucleotides; Estrogens; Female; In Vitro Techniques; Luteinizing Hormone; Ovarian Follicle; Progestins; Puromycin; Rabbits; Steroids; Stimulation, Chemical; Theophylline | 1975 |
Studies on regulatory factors of ornithine decarboxylase activity during development of mouse mammary epithelium in vitro.
Topics: Animals; Bucladesine; Carboxy-Lyases; Cyclic AMP; Cycloheximide; Epithelial Cells; Epithelium; Female; Hydrocortisone; Insulin; Mammary Glands, Animal; Mice; Organ Culture Techniques; Ornithine Decarboxylase; Prolactin; Prostaglandins E; Theophylline | 1976 |
[The stimulating effect of cyclic AMP, glucagon and insulin on guanidine acetate-N-methyltransferase activity in rat liver and pancreas].
Topics: Animals; Bucladesine; Caffeine; Cyclic AMP; Cycloheximide; Glucagon; Insulin; Liver; Magnesium; Methyltransferases; Oligomycins; Pancreas; Rats; Theophylline | 1976 |
Stimulation of ribonuclease activity and its isoenzymes in germinating seeds of cowpea (Vigna sinensis) by gibberellic acid and adenosine-3',5-cyclic monophosphate.
Topics: Adenine; Adenine Nucleotides; Adenosine; Cyclic AMP; Cycloheximide; Dactinomycin; Gibberellins; Isoenzymes; Plant Proteins; Ribonucleases; RNA; Seeds; Theophylline | 1976 |
Cell to substratum adhesion-promoting activity released by normal and virus-transformed cells in culture.
Topics: Bucladesine; Calcium; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cold Temperature; Culture Media; Cycloheximide; Hot Temperature; Kinetics; Magnesium; Theophylline | 1976 |
Stimulation of colonic glycoprotein synthesis by dibutyryl cyclic AMP and theophylline.
Topics: Animals; Bucladesine; Colon; Cycloheximide; Galactosyltransferases; Glucosamine; Glycoproteins; Organ Culture Techniques; Rabbits; Theophylline | 1977 |
Changes in the activities of the enzymes of urea synthesis caused by dexamethasone and dibutyryladenosine 3':5'-cyclic monophosphate in foetal rat liver maintained in organ culture.
Topics: Animals; Arginase; Argininosuccinate Lyase; Argininosuccinate Synthase; Bucladesine; Carbamoyl-Phosphate Synthase (Ammonia); Cycloheximide; Dexamethasone; Enzyme Induction; Liver; Organ Culture Techniques; Ornithine Carbamoyltransferase; Rats; Theophylline; Urea | 1976 |
Tentative mechanism of lymphocyte chalone action.
Topics: Animals; Bucladesine; Cattle; Cycloheximide; Cytarabine; DNA; Growth Inhibitors; In Vitro Techniques; Lectins; Leucine; Lymphocyte Activation; Lymphocytes; Spleen; Theophylline; Thymidine; Time Factors; Uridine | 1977 |
[Alkaline phosphatase activity in normal and SV40 virus-transformed hamster fibroblasts. Effect of cyclic AMP].
Topics: Alkaline Phosphatase; Bucladesine; Cell Line; Cell Transformation, Neoplastic; Cycloheximide; Dose-Response Relationship, Drug; Drug Synergism; Fibroblasts; Simian virus 40; Theophylline | 1977 |
Regulation of hypoxanthine transport by cyclic nucleotides in cultured Chinese hamster lung fibroblasts.
Topics: Bucladesine; Cells, Cultured; Cyclic GMP; Cycloheximide; Dactinomycin; DNA; Fibroblasts; Glucagon; Hydroxyurea; Hypoxanthines; Insulin; Nucleotides, Cyclic; Theophylline; Thymidine; Xanthines | 1977 |
Induction of melanogenesis in vitro in the epidermal melanoblasts of newborn mouse skin by MSH.
Topics: Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Bucladesine; Cells, Cultured; Cycloheximide; Dactinomycin; Estradiol; Melanins; Melanocyte-Stimulating Hormones; Melanocytes; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Theophylline | 1977 |
Amphibian oocyte maturation and protein synthesis: related inhibition by cyclic AMP, theophylline, and papaverine.
Topics: Animals; Calcium; Chorionic Gonadotropin; Cyclic AMP; Cycloheximide; Egg Proteins; Female; Lanthanum; Oocytes; Oogenesis; Papaverine; Progesterone; Testosterone; Theophylline; Xenopus | 1978 |
Decrease of rat liver cysteine dioxygenase (cysteine oxidase) activity mediated by glucagon.
Topics: Adrenal Glands; Animals; Bucladesine; Cycloheximide; Cysteine; Dactinomycin; Drug Synergism; Glucagon; Liver; Male; Oxygenases; Rats; Theophylline | 1978 |
Induction of mitochondrial phosphoenolpyruvate carboxykinase in cultured human fibroblasts.
Topics: Bucladesine; Cells, Cultured; Cycloheximide; Dactinomycin; Dexamethasone; Enzyme Induction; Humans; Hydrocortisone; Insulin; Mitochondria; Phosphoenolpyruvate Carboxykinase (GTP); Theophylline | 1978 |
Glucagon influences the expression of thyroid hormone action: discrepancy between nuclear triiodothyronine receptor number and enzyme responses.
Topics: Animals; Bucladesine; Cycloheximide; Glucagon; Glycerolphosphate Dehydrogenase; Malate Dehydrogenase; Male; Rats; Receptors, Cell Surface; Theophylline; Triiodothyronine | 1979 |
Factors promoting colony stimulating activity (CSA) production in macrophages and epithelial cells.
Topics: Animals; Ascitic Fluid; Blood; Cells, Cultured; Colony-Stimulating Factors; Complement C3; Complement C5; Cyclic AMP; Cyclic GMP; Cycloheximide; Endotoxins; Epithelial Cells; Epithelium; Inulin; Latex; Lithium; Macrophages; Mice; Microspheres; Theophylline; Thymus Gland; Zymosan | 1979 |
Selected hormonal effects on protein secretion and amino acid uptake by acini from bovine mammary gland.
Topics: Amino Acids; Animals; Biological Transport; Bucladesine; Cattle; Cyclic AMP; Cycloheximide; Cycloleucine; Female; In Vitro Techniques; Insulin; Mammary Glands, Animal; Milk Proteins; Stimulation, Chemical; Theophylline | 1979 |
Effect of cyclic nucleotides and phosphodiesterase inhibition on morphine tolerance and physical dependence.
Topics: Adrenergic beta-Antagonists; Animals; Cyclic AMP; Cyclic GMP; Cycloheximide; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Phosphodiesterase Inhibitors; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline | 1975 |
Protein synthesis inhibitors and gastric acid secretion.
Topics: Animals; Anura; Cell Membrane; Cycloheximide; Gastric Juice; Gastric Mucosa; In Vitro Techniques; Leucine; Oxygen Consumption; Protein Biosynthesis; Puromycin; Rana catesbeiana; Theophylline | 1978 |
Calcium, potassium, and sodium exchange by full-grown and maturing Xenopus laevis oocytes.
Topics: Animals; Calcium; Cortisone; Cycloheximide; Female; Kinetics; Oocytes; Ovum; Potassium; Progesterone; Sodium; Testosterone; Theophylline; Xenopus | 1977 |
Post-translational regulation of lipoprotein lipase activity in adipose tissue.
Topics: Adipose Tissue; Animals; Cycloheximide; Enzyme Activation; Epinephrine; In Vitro Techniques; Kinetics; Lipoprotein Lipase; Male; Rats; Theophylline; Uncoupling Agents | 1978 |
A physicochemical analysis of conjugation in Tetrahymena pyriformis.
Topics: Amino Acids; Animals; Caffeine; Calcium; Colchicine; Conjugation, Genetic; Culture Media; Cycloheximide; Dactinomycin; Dithiothreitol; Egtazic Acid; Kinetics; Magnesium; Manganese; Potassium; Sodium; Temperature; Tetrahymena pyriformis; Theophylline; Zinc | 1976 |
Stimulation of melanotic expression in a melanoma cell line by theophylline.
Topics: Catechol Oxidase; Cell Count; Cell Division; Cell Line; Cycloheximide; DNA; Dose-Response Relationship, Drug; Melanins; Papaverine; Protein Biosynthesis; Theophylline; Thiouracil | 1976 |
Selective incorporation of L-3,4-dihydroxyphenylalanine by S-91 Cloudman melanoma in vitro.
Topics: Cells, Cultured; Cycloheximide; Levodopa; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Neoplasms, Experimental; Theophylline; Tyrosine | 1977 |
The influence of methylxanthines on precursor incorporation into protein and RNA of mouse brain.
Topics: Aminophylline; Animals; Animals, Newborn; Brain; Cycloheximide; Isoleucine; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Penicillins; Pentoxifylline; RNA; Streptomycin; Theophylline; Time Factors; Uridine; Xanthines | 1976 |
[Specificity and mechanism of serotonin stimulation of adenylate deaminase activity].
Topics: Amines; AMP Deaminase; Animals; Cycloheximide; Dactinomycin; Drug Interactions; Enzyme Activation; Enzyme Repression; Mice; Mice, Inbred CBA; Mitochondria, Liver; Nucleotide Deaminases; Rats; Rats, Inbred Strains; Serotonin; Stimulation, Chemical; Theophylline | 1975 |
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.
Topics: 1-Methyl-3-isobutylxanthine; Aprotinin; Blotting, Northern; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; DNA Replication; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Leupeptins; Male; Pentoxifylline; Phenylmethylsulfonyl Fluoride; Prostatic Neoplasms; RNA, Neoplasm; Theophylline; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Expression of the V(D)J recombinase gene RAG-1 is tightly regulated and involves both transcriptional and post-transcriptional controls.
Topics: Animals; Blotting, Northern; Cell Line; Cycloheximide; DNA Nucleotidyltransferases; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Homeodomain Proteins; Humans; Interleukin-2; Lymphocytes; Nuclear Proteins; Protein Biosynthesis; Rats; RNA Processing, Post-Transcriptional; RNA, Messenger; Tetradecanoylphorbol Acetate; Theophylline; Transcription, Genetic; VDJ Recombinases | 1992 |
Multihormonal regulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression in primary cultures of rat hepatocytes.
Topics: Animals; Blotting, Northern; Bucladesine; Cells, Cultured; Cycloheximide; Dactinomycin; Dexamethasone; Gene Expression Regulation, Enzymologic; Insulin; Kinetics; Liver; Male; Phosphofructokinase-2; Phosphoric Monoester Hydrolases; Phosphotransferases; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Theophylline; Triiodothyronine | 1990 |
cAMP stimulation of acetylcholine receptor expression is mediated through posttranslational mechanisms.
Topics: Animals; Bungarotoxins; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; DNA; Kinetics; L Cells; Macromolecular Substances; Mice; Protein Processing, Post-Translational; Receptors, Cholinergic; Theophylline; Thionucleotides; Torpedo; Transfection | 1991 |
Avidin induction by theophylline in vivo and in vitro.
Topics: Animals; Avidin; Biotin; Chickens; Culture Techniques; Cycloheximide; Dactinomycin; Diethylstilbestrol; Hot Temperature; Kinetics; Ovalbumin; Oviducts; Progesterone; Protein Biosynthesis; RNA; Theophylline; Tissue Distribution | 1986 |
The in vitro effects of cyclic nucleotides, cyanoketone, and cycloheximide on the production of estradiol-17 beta by vitellogenic ovarian follicles of goldfish (Carassius auratus).
Topics: 1-Methyl-3-isobutylxanthine; Androstenols; Animals; Aromatase; Bucladesine; Chorionic Gonadotropin; Cyanoketone; Cyclic AMP; Cyclic GMP; Cycloheximide; Cyprinidae; Dibutyryl Cyclic GMP; Estradiol; Female; Goldfish; Nucleotides, Cyclic; Ovarian Follicle; Theophylline; Time Factors; Vitellogenesis | 1986 |
Epidermal growth factor stimulates formation of inositol phosphates in BALB/c/3T3 cells pretreated with cholera toxin and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cholera Toxin; Cycloheximide; Epidermal Growth Factor; Inositol Phosphates; Mice; Mice, Inbred BALB C; Platelet-Derived Growth Factor; Sugar Phosphates; Theophylline | 1988 |
Elevation of angiotensin converting enzyme by 3-isobutyl-1-methylxanthine in cultured endothelial cells: a possible role for calmodulin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calmodulin; Cattle; Cells, Cultured; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Imidazoles; Indomethacin; Peptidyl-Dipeptidase A; Propranolol; Theophylline; Trifluoperazine; Verapamil; Xanthines | 1988 |
Mitogenic activity of phorbol esters and insulin-like growth factor 1 in chemically transformed mouse fibroblasts BP-A31: independent effects and differential sensitivity to inhibition by 3-isobutyl-1-methyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cell Division; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Insulin; Insulin-Like Growth Factor I; Mice; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Somatomedins; Suramin; Tetradecanoylphorbol Acetate; Theophylline | 1989 |
Regulation of growth hormone-independent insulin-like growth factor-binding protein (BP-28) in cultured human fetal liver explants.
Topics: Amniotic Fluid; Carrier Proteins; Colforsin; Culture Techniques; Cycloheximide; Dexamethasone; Fetus; Glucagon; Glucose; Humans; Immunochemistry; Insulin; Insulin-Like Growth Factor Binding Proteins; Liver; Theophylline | 1989 |
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animals; Biopterins; Cell Line; Colforsin; Cycloheximide; Dihydropteridine Reductase; GTP Cyclohydrolase; Isoenzymes; Kinetics; Pheochromocytoma; Pteridines; Pterins; Rats; Reserpine; Theophylline | 1989 |
Early and delayed changes in potassium transport during the initiation of cell proliferation in CHO culture.
Topics: Animals; Biological Transport, Active; Blood; Cell Division; Cell Line; Cycloheximide; DNA; Interphase; Isoproterenol; Mitogens; Potassium; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase; Theophylline; Time Factors | 1989 |
Coordinate regulation of adenosine A1 and A2 receptors.
Topics: Adenosine; Alprostadil; Animals; Binding Sites; Cell Line; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Ethanol; Mice; Receptors, Purinergic; Theophylline; Time Factors | 1989 |
Steroid secretion by ovarian cells of the Japanese quail (Coturnix coturnix japonica).
Topics: Androstenedione; Animals; Bucladesine; Chorionic Gonadotropin; Coturnix; Cycloheximide; Estradiol; Estrogens; Estrone; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Ovary; Oviposition; Ovulation; Progesterone; Quail; Testosterone; Theophylline; Time Factors | 1988 |
Effect of glucose on induction of delta-aminolevulinic acid synthase, ferrochelatase and cytochrome P-450 hemoproteins in isolated rat hepatocytes by phenobarbital and lead.
Topics: 5-Aminolevulinate Synthetase; Animals; Bucladesine; Cells, Cultured; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Epinephrine; Ferrochelatase; Glucose; Hemeproteins; Insulin; Lead; Liver; Lyases; Male; Phenobarbital; Rats; Subcellular Fractions; Theophylline | 1985 |
Biochemical mechanisms of regulation of mucus secretion by prostaglandin E2 in rat gastric mucosa.
Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Cycloheximide; Dinoprostone; Gastric Mucosa; Glycoproteins; In Vitro Techniques; Indicators and Reagents; Male; Mucus; Prostaglandins E; Rats; Rats, Inbred Strains; Theophylline | 1985 |
Stimulation by glucagon and adenosine-3',5'-cyclic monophosphate of protein degradation in Reuber H35 hepatoma monolayers.
Topics: Animals; Cell Line; Cyclic AMP; Cycloheximide; Glucagon; Insulin; Kinetics; Liver Neoplasms, Experimental; Neoplasm Proteins; Puromycin; Rats; Theophylline | 1987 |
The lipoprotein lipase of white adipose tissue. Changes in the adipocyte cell-surface content of enzyme in response to extracellular effectors in vitro.
Topics: Adipose Tissue; Animals; Cell Membrane; Colchicine; Cycloheximide; Dexamethasone; Epinephrine; Glucagon; Heparin; Immunoassay; In Vitro Techniques; Insulin; Lipoprotein Lipase; Rats; Theophylline; Tunicamycin | 1986 |
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, Nonmammalian; Emetine; Fluorouracil; Hydroxyurea; Theobromine; Theophylline; Xanthines; Xenopus laevis | 1987 |
Forskolin induction of S-100 protein in glioma and hybrid cells.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Cell Line; Colforsin; Cycloheximide; Dactinomycin; Diterpenes; Glioma; Hybrid Cells; Isoproterenol; Kinetics; Mice; Neuroblastoma; Prostaglandins E; Rats; S100 Proteins; Theophylline | 1985 |
Cyclic AMP: testosterone-like stimulation of prostatic enzymes.
Topics: Animals; Castration; Cyclic AMP; Cycloheximide; Dactinomycin; Glucosephosphate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycerolphosphate Dehydrogenase; Hexokinase; Male; Phosphofructokinase-1; Phosphogluconate Dehydrogenase; Prostate; Pyruvate Kinase; Rats; Stimulation, Chemical; Testosterone; Theophylline | 1971 |
Induction of alkaline phosphatase by cyclic AMP or its dibutyryl derivative in a hybrid line between mouse and Chinese hamster in culture.
Topics: Alkaline Phosphatase; Animals; Butyrates; Cell Line; Cricetinae; Cyclic AMP; Cycloheximide; Dactinomycin; Drug Antagonism; Drug Synergism; Enzyme Induction; Hybrid Cells; In Vitro Techniques; Mice; Theophylline | 1972 |
Metabolic control mechanisms in mammalian systems. Involvement of adenosine 3':5'-cyclic monophosphate in androgen action.
Topics: Androgens; Animals; Castration; Cyclic AMP; Cycloheximide; Dactinomycin; Glyceraldehyde-3-Phosphate Dehydrogenases; Hexokinase; Male; Phosphofructokinase-1; Prostate; Pyruvate Kinase; Rats; Seminal Vesicles; Testosterone; Theophylline | 1971 |
Metabolic control mechanisms in mammalian systems. XV. Studies on the role of adenosine 3' ,5'-monophosphate in estrogen action on the uterus.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Adrenal Glands; Animals; Cyclic AMP; Cycloheximide; Dactinomycin; Estrogens; Female; Glucosephosphate Dehydrogenase; Glycogen; Hexokinase; Hexosephosphates; Kinetics; Lung; Phosphofructokinase-1; Pyruvate Kinase; Rats; Theophylline; Thymus Gland; Uterus | 1972 |
The stimulating action of gastrin pentapeptide, histamine and cyclic adenosine 3',5'-monophosphate on carbonic anhydrase in rat stomach.
Topics: Animals; Carbonic Anhydrases; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Flavonoids; Gastric Juice; Gastric Mucosa; Histamine; Pentagastrin; Rats; Stomach; Theophylline | 1972 |
Lipolytic effects of high concentrations of insulin on isolated fat cells. Enhancement of the response to lipolytic hormones.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Fatty Acids, Nonesterified; gamma-Globulins; Glycerol; Insulin; Insulin Antibodies; Puromycin; Rats; Theophylline; Trypsin; Trypsin Inhibitors | 1973 |
Effects of dibutyryl cyclic AMP and prostaglandin E1 on cultured human glioma cells.
Topics: Blood Proteins; Bucladesine; Cell Line; Culture Media; Cycloheximide; Dactinomycin; Glioma; Humans; Leucine; Prostaglandins; Staining and Labeling; Theophylline; Tritium; Vinblastine | 1974 |
Cyclic AMP and intestinal glycoprotein synthesis: the effect of -adrenergic agents, theophylline, and dibutyryl cyclic AMP.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carbon Isotopes; Cyclic AMP; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epinephrine; Glucosamine; Glycoproteins; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Isoproterenol; Male; Rats; Subcellular Fractions; Theophylline | 1973 |
Enzyme induction in human fetal liver in organ culture.
Topics: Animals; Arginine; Bucladesine; Carbon Radioisotopes; Cycloheximide; Dexamethasone; Female; Fetus; Gestational Age; Humans; Ligases; Liver; Lyases; Organ Culture Techniques; Phenylalanine Hydroxylase; Pregnancy; Rats; Species Specificity; Succinates; Theophylline; Time Factors; Triamcinolone; Tyrosine Transaminase | 1973 |
Cyclic AMP-mediated induction of the cyclic AMP phosphodiesterase of C-6 glioma cells.
Topics: Animals; Bucladesine; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Glioma; Isoproterenol; Kinetics; Leucine; Norepinephrine; Phenoxybenzamine; Phosphoric Diester Hydrolases; Propranolol; Rats; Theophylline; Tritium | 1974 |
Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. Effects of administration of glucose, cyclic AMP, and some hormones related to glucose metabolism.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Adenosine Triphosphate; Allylisopropylacetamide; Animals; Bucladesine; Cyclic AMP; Cycloheximide; Cytosol; Diabetes Mellitus, Experimental; Enzyme Induction; Epinephrine; Ethylenediamines; Glucagon; Glucose; Glutamate Dehydrogenase; Half-Life; Insulin; Isoproterenol; Kinetics; Liver; Male; Mitochondria, Liver; Rats; Succinate Dehydrogenase; Theophylline; Time Factors; Tyrosine Transaminase | 1974 |
The long-term regulation of tyrosine hydroxylase activity in cultured sympathetic ganglia: role of ganglionic noradrenaline content.
Topics: Acetylesterase; Aging; Animals; Animals, Newborn; Bucladesine; Carbachol; Choline; Cyclic AMP; Cycloheximide; Dactinomycin; Ganglia, Autonomic; Ganglia, Spinal; Methyltyrosines; Mice; Nerve Growth Factors; Neurons; Norepinephrine; Organ Culture Techniques; Ouabain; Potassium; Receptors, Drug; Reserpine; Theophylline; Time Factors; Tyrosine 3-Monooxygenase | 1974 |
A failure of specific inhibitors to affect survival of Chinese hamster cells exposed to ultra-violet light.
Topics: Acridines; Animals; Caffeine; Chloramphenicol; Clone Cells; Cricetinae; Cycloheximide; Dactinomycin; Puromycin; Radiation Effects; Theophylline; Ultraviolet Rays | 1967 |
Effects of growth hormone on the lipolytic response of adipose tissue to theophylline.
Topics: Adipose Tissue; Animals; Cyclic AMP; Cycloheximide; Dexamethasone; Fatty Acids, Nonesterified; Glycerol; Growth Hormone; Hypophysectomy; In Vitro Techniques; Insulin; Lipid Metabolism; Lipotropic Agents; Male; Rats; Theophylline | 1968 |
An in vitro effect of triiodothyronine on rat adipose tissue.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Cycloheximide; Epinephrine; Fatty Acids; Glucagon; Glucose; Glycerides; In Vitro Techniques; Propylthiouracil; Rats; Theophylline; Thyrotropin; Triiodothyronine | 1967 |
Stimulation by growth hormone and dexamethasone of labeled cyclic adenosine 3',5'-monophosphate accumulation by white fat cells.
Topics: Adenine; Adenine Nucleotides; Adipose Tissue; Animals; Cyclic AMP; Cycloheximide; Depression, Chemical; Dexamethasone; Epinephrine; Ergotamine; Fatty Acids, Nonesterified; Female; Glucosyltransferases; Glycerol; Growth Hormone; Lipid Metabolism; Ovary; Propranolol; Protein Biosynthesis; Puromycin; Rats; Stimulation, Chemical; Theophylline; Time Factors; Tritium; Uterus | 1970 |
Effect of dibutyryl-3',5'-AMP, theophylline and norepinephrine on lipolytic action of growth hormone and glucocorticoid in white fat cells.
Topics: Adenine Nucleotides; Adipose Tissue; Animals; Butyrates; Cyclic AMP; Cycloheximide; Female; Glucocorticoids; Growth Hormone; Norepinephrine; Rats; Theophylline | 1968 |
Induction of uterine phosphofructokinase by cyclic 3',5'-adenosine monophosphate.
Topics: Adenine Nucleotides; Animals; Castration; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Estradiol; Estrogens; Female; Organ Size; Phosphofructokinase-1; Rats; Theophylline; Uterus | 1970 |
Enzyme regulation in gluconeogenesis and lipogenesis. Relationship of protein synthesis and cyclic AMP to lipolytic action of growth hormone and glucocorticoids.
Topics: Adenine Nucleotides; Adipose Tissue; Animals; Cyclic AMP; Cycloheximide; Dexamethasone; Epinephrine; Growth Hormone; In Vitro Techniques; Insulin; Leucine; Lipid Metabolism; Protein Biosynthesis; Rats; RNA; Theophylline; Time Factors; Tritium | 1971 |
Effect of cyclic adenosine-3',5'-monophosphate on bone marrow delta-aminolevulinic acid synthetase and erythrocyte iron uptake.
Topics: Acyltransferases; Adenine Nucleotides; Amino Acids; Animals; Bone Marrow; Bone Marrow Cells; Culture Techniques; Cyclic AMP; Cycloheximide; Dactinomycin; Erythrocytes; Erythropoiesis; Erythropoietin; Heme; Iron; Iron Isotopes; Levulinic Acids; Mice; Mitochondria; Rabbits; Stimulation, Chemical; Succinates; Theophylline | 1971 |
Pineal gland in organ culture. II. Role of adenosine 3',5'-monophosphate in the regulation of radiolabeled melatonin production.
Topics: Adenine Nucleotides; Animals; Carbon Isotopes; Chromatography, Thin Layer; Cyclic AMP; Cycloheximide; Dactinomycin; Female; Fenclonine; Melatonin; Methyltransferases; Organ Culture Techniques; Pineal Gland; Rats; Serotonin; Stimulation, Chemical; Theophylline; Tritium; Tryptophan | 1971 |
Early events in hormonal induction of alkaline phosphatase in human cell culture: hormone-cell interaction and its dependence of DNA replication.
Topics: Aldosterone; Alkaline Phosphatase; Antigen-Antibody Reactions; Butyrates; Carbon Isotopes; Cell Line; Chromatography, Gel; Corticosterone; Cortisone; Cyclic AMP; Cycloheximide; Enzyme Induction; Epinephrine; Female; HeLa Cells; Humans; Hydrocortisone; Hydroxyprogesterones; Kinetics; Leucine; Mitosis; Precipitin Tests; Prednisolone; Pregnenolone; Progesterone; Protein Biosynthesis; Spectrophotometry; Theophylline; Tritium | 1971 |
Inhibition by cycloheximide and dactinomycin of the activation of lipolysis due to growth hormone in white fat cells.
Topics: Adipose Tissue; Animals; Butyrates; Cattle; Cyclic AMP; Cycloheximide; Dactinomycin; Depression, Chemical; Dexamethasone; Female; Glucocorticoids; Growth Hormone; Hypophysectomy; Lipid Metabolism; Metabolism; Norepinephrine; Pituitary Gland; Rats; Starvation; Stimulation, Chemical; Theophylline; Uterus | 1970 |
Stimulation of adrenal cholesterol side chain cleavage activity by theophylline.
Topics: Adrenal Glands; Animals; Butyrates; Carbon Isotopes; Carboxylic Acids; Cholesterol; Cyclic AMP; Cycloheximide; Esters; Female; Glycine; Peptide Chain Elongation, Translational; Protein Biosynthesis; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Time Factors | 1971 |
Effect of growth hormone on isolated rat diaphragm. Possible role of adenosine 3',5'-monophosphoric acid (cyclic AMP).
Topics: Animals; Carbon Isotopes; Cattle; Cyclic AMP; Cycloheximide; Depression, Chemical; Diaphragm; Drug Synergism; Enzyme Activation; Growth Hormone; Hypophysectomy; Imidazoles; In Vitro Techniques; Metabolism; Muscles; Permeability; Phosphoric Monoester Hydrolases; Pituitary Gland; Protein Biosynthesis; Puromycin; Rats; Stimulation, Chemical; Theophylline; Time Factors; Xylose | 1971 |
Pineal gland: stimulation of melatonin production by norepinephrine involves cyclic AMP-mediated stimulation of N-acetyltransferase.
Topics: Adenylyl Cyclases; Animals; Chromatography, Thin Layer; Cyclic AMP; Cycloheximide; Dactinomycin; Hydroxyindoleacetic Acid; Indoles; Melatonin; Methyltransferases; Norepinephrine; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Pineal Gland; Rats; Serotonin; Stimulation, Chemical; Theophylline; Transferases; Tritium; Tryptophan | 1970 |
Induction of bone resorption in tissue culture. Prolonged response after brief exposure to parathyroid hormone or 25-hydroxycholecalciferol.
Topics: Alkaloids; Animals; Bone Resorption; Calcitonin; Calcium; Calcium Isotopes; Cholecalciferol; Cyclic AMP; Cycloheximide; Dactinomycin; Female; Fetus; Magnesium; Orotic Acid; Parathyroid Hormone; Phosphates; Plicamycin; Prostaglandins; RNA; Theophylline; Time Factors; Tritium; Uridine; Vitamin A | 1972 |
Thyrotrophin-induced aggregation and reorganization into follicles of isolated porcine-thyroid cells. 1. Mechanism of action of thyrotrophin and metabolic properties.
Topics: Animals; Carbon Isotopes; Cell Differentiation; Cells, Cultured; Cyclic AMP; Cycloheximide; Dactinomycin; DNA; In Vitro Techniques; Iodides; Protein Biosynthesis; Puromycin; RNA; Swine; Theophylline; Thyroglobulin; Thyroid Gland; Thyroid Hormones; Thyrotropin; Time Factors; Ultracentrifugation | 1971 |
Regulation of adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in fibroblasts by intracellular concentrations of cyclic adenosine monophosphate (3T3-dibutyryl cyclic AMP-SV40-transformed cells-michaelis constants-L cells-prostaglandin E 1 )
Topics: Animals; Butyrates; Cell Line; Contact Inhibition; Cyclic AMP; Cycloheximide; Dactinomycin; Depression, Chemical; Enzyme Activation; Enzyme Induction; Fibroblasts; Kinetics; L Cells; Mice; Phosphoric Monoester Hydrolases; Prostaglandins; Simian virus 40; Stimulation, Chemical; Theophylline; Tritium | 1972 |
Stimulation by dibutyryl cyclic AMP of serotonin synthesis and tryptophan transport in brain slices.
Topics: Adenosine Monophosphate; Animals; Biological Transport; Brain; Butyrates; Cyclic AMP; Cycloheximide; Glucagon; Hydroxyindoleacetic Acid; Male; Norepinephrine; Osmolar Concentration; Rats; Serotonin; Theophylline; Tritium; Tryptophan; Tyrosine | 1972 |
Inhibitors of cyclic-nucleotide phosphodiesterase induce morphological differentiation of mouse neuroblastoma cell culture.
Topics: Animals; Axons; Benzyl Compounds; Cell Count; Cell Differentiation; Cells, Cultured; Culture Media; Cycloheximide; Dactinomycin; Ethers; Imidazoles; Ketones; Methyl Ethers; Mice; Mycotoxins; Neoplasms, Experimental; Neuroblastoma; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Monoester Hydrolases; Theophylline; Time Factors; Vinblastine | 1972 |
Effect of dibutyryl cyclic AMP on interferon production by cells treated with viral or nonviral inducers. 1.
Topics: Animals; Arbovirus Infections; Cells, Cultured; Chikungunya virus; Cyclic AMP; Cycloheximide; Epinephrine; Inosine Nucleotides; Interferons; L Cells; Mice; Newcastle Disease; Polynucleotides; Protein Biosynthesis; Rats; Theophylline | 1972 |
Studies on the mechanism of action of angiotensin on fluid transport by the mucosa of rat distal colon.
Topics: Adrenalectomy; Angiotensin II; Animals; Biological Transport, Active; Colon; Cyclic AMP; Cycloheximide; Dactinomycin; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Leucine; Nephrectomy; Protein Biosynthesis; Puromycin; Rats; RNA; Stimulation, Chemical; Theophylline; Uridine; Water | 1972 |
Amino acid transport in bone: stimulation by cyclic AMP.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Calcitonin; Carbon Isotopes; Collagen; Cyclic AMP; Cycloheximide; Fetus; In Vitro Techniques; Insulin; Parathyroid Hormone; Proline; Prostaglandins; Puromycin; Rats; Skull; Sodium; Stimulation, Chemical; Theophylline; Tritium | 1973 |
Cyclic 3',5'-AMP phosphodiesterase activity during cyclic AMP-induced differentiation of neuroblastoma cells in culture.
Topics: Animals; Benzyl Compounds; Butyrates; Cell Differentiation; Cells, Cultured; Cyclic AMP; Cycloheximide; Dactinomycin; Ethers; Imidazoles; Ketones; Mice; Neuroblastoma; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Prostaglandins; Radiation Effects; Sodium; Theophylline | 1973 |
[Effect of cAMP and of regulator protein on the in vitro action of human chorionic gonadotropin (HCG) on the corpus luteum].
Topics: Carbon Isotopes; Chorionic Gonadotropin; Corpus Luteum; Cyclic AMP; Cycloheximide; Female; Humans; Imidazoles; In Vitro Techniques; Oxygen; Progesterone; Stimulation, Chemical; Theophylline | 1972 |
Pleiotypic control by adenosine 3':5'-cyclic monophosphate: a model for growth control in animal cells.
Topics: Animals; Biological Transport; Butyrates; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic AMP; Cycloheximide; DNA; Fibroblasts; Glucose; Immune Sera; Leucine; Mice; Mice, Inbred Strains; Models, Biological; Prostaglandins; RNA; Simian virus 40; Theophylline; Thymidine; Uridine | 1973 |
Uptake of vitamin B 12 by phytohaemagglutinin-transformed lymphocytes.
Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Chloramphenicol; Cyclic AMP; Cycloheximide; Dactinomycin; DNA; Edetic Acid; Female; Folic Acid Deficiency; Hematopoiesis; Humans; Lectins; Leukocytes; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Puromycin; RNA; Theophylline; Time Factors; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
Pleiotypic control by cyclic AMP: interaction with cyclic GMP and possible role of microtubules.
Topics: Animals; Biological Transport; Cell Line; Colchicine; Cyclic AMP; Cyclic GMP; Cycloheximide; Fibroblasts; Kinetics; Leucine; Mice; Microtubules; Prostaglandin Antagonists; Prostaglandins; Stimulation, Chemical; Theophylline; Uridine; Vinblastine | 1973 |
Studies on the postnatal development of responses of hepatic histidase to endocrine control.
Topics: Ammonia-Lyases; Animals; Butyrates; Castration; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Estradiol; Ethionine; Female; Glucagon; Histidine Ammonia-Lyase; Hydrocortisone; Hypophysectomy; Liver; Ovary; Pituitary Gland; Rats; Sex Factors; Theophylline | 1973 |
Stimulation of ornithine decarboxylase and nuclear RNA polymerase activity in rat liver by glucagon and dibutyryl cyclic amp.
Topics: Adenosine; Adrenalectomy; Animals; Bucladesine; Carbon Radioisotopes; Carboxy-Lyases; Cycloheximide; Dactinomycin; Depression, Chemical; DNA-Directed RNA Polymerases; Dose-Response Relationship, Drug; Female; Glucagon; Liver; Mycotoxins; Nucleotides; Ornithine; Rats; Stimulation, Chemical; Theophylline; Time Factors | 1973 |
The effect of stress induced by ether anaesthesia on cholesterol content and cholesteryl-esterase activity in rat-adrenal cortex.
Topics: Adenosine Triphosphate; Adrenal Glands; Adrenocorticotropic Hormone; Anesthesia, Inhalation; Animals; Cholesterol; Cyclic AMP; Cycloheximide; Esterases; Ethyl Ethers; Female; Phosphotransferases; Rats; Stress, Physiological; Theophylline | 1973 |
Connective tissue activation. VI. The effects of cylic nucleotides on human synovial cells in vitro.
Topics: Adenosine Monophosphate; Bucladesine; Butyrates; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cycloheximide; Depression, Chemical; Drug Synergism; Fibroblasts; Glucose; Glycolysis; Humans; Hyaluronic Acid; Hydrocortisone; Lactates; Nucleotides, Cyclic; Peptides; Stimulation, Chemical; Synovial Membrane; Theophylline | 1974 |
Adrenocorticotropic hormone and dibutryl adenosine cyclic monophosphate-mediated Ca2+ uptake by rat adrenal glands.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Biological Transport; Biological Transport, Active; Bucladesine; Calcium; Calcium Isotopes; Calcium Radioisotopes; Corticosterone; Cycloheximide; Dactinomycin; Female; Hypophysectomy; Inulin; Pituitary Gland; Rats; Spectrophotometry, Atomic; Steroids; Theophylline; Time Factors; Tritium | 1973 |
Sequence of events mediating the effect of cholera toxin on rat thymocytes.
Topics: Aminoisobutyric Acids; Animals; Calcium; Cholera; Cyclic AMP; Cycloheximide; Epinephrine; Ethacrynic Acid; Insulin; Iodine Radioisotopes; Isoproterenol; Lymphocytes; Polymyxins; Potassium; Prostaglandins; Rats; Sodium; Theophylline; Thymus Gland; Time Factors; Toxins, Biological; Toxoids | 1974 |
Protein synthesis by isolated spermatozoa from cauda and caput epididymis of rat.
Topics: Animals; Chloramphenicol; Cyclic AMP; Cycloheximide; Epididymis; Glucose; Male; Mitochondria; Protein Biosynthesis; Rats; Spermatozoa; Tail; Theophylline; Time Factors | 1973 |
Cyclic 3',5'-adenosine monophosphate stimulates trehalose degradation in baker's yeast.
Topics: Carbon Radioisotopes; Cell Division; Cell-Free System; Cyclic AMP; Cycloheximide; Enzyme Activation; Glucose; Inulin; Lithium; Saccharomyces cerevisiae; Spectrophotometry, Atomic; Stimulation, Chemical; Theophylline; Time Factors; Trehalase; Trehalose | 1974 |
Effect of dibutyryl cyclic amp on glucose-6-phosphatase activity in human fetal liver explants.
Topics: Bucladesine; Cycloheximide; Dactinomycin; Drug Synergism; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fetus; Gestational Age; Glucose-6-Phosphatase; Humans; Insulin; Liver; Organ Culture Techniques; Theophylline; Time Factors | 1974 |
Induction of alkaline phosphatase activity by dibutyryl adenosine 3':5'-cyclic monophosphate in aneuploid rat liver cells.
Topics: Alkaline Phosphatase; Aneuploidy; Animals; Bucladesine; Cell Fractionation; Cell Line; Clone Cells; Colchicine; Cycloheximide; Cytarabine; Dactinomycin; Enzyme Induction; Epithelial Cells; Epithelium; Liver; Microscopy, Electron; Rats; Theophylline; Tritium | 1974 |
Lipolytic effects of sheep beta-lipotropin in rat adipose tissue: interaction with theophylline and dihydroergotamine.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; beta-Lipotropin; Cycloheximide; Dexamethasone; Dihydroergotamine; Ergotamine; Fasting; Fatty Acids; Glycerol; Growth Hormone; Humans; In Vitro Techniques; Lipid Mobilization; Male; Rats; Sheep; Theophylline; Time Factors; Triglycerides | 1974 |
Multiple control mechanisms underlie initiation of growth in animal cells.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Deoxyglucose; Enzyme Inhibitors; Fibroblasts; Kinetics; Mice; Mice, Inbred Strains; Ouabain; Phosphates; Phosphorus Radioisotopes; Prostaglandins; Stimulation, Chemical; Theophylline; Tritium; Uridine | 1974 |
Hormonal regulation of amino acid accumulation in human fetal liver explants. Effects of dibutyryl cyclic AMP, glucogon and insulin.
Topics: Alanine; Aminoisobutyric Acids; Biological Transport; Bucladesine; Carbon Radioisotopes; Cycloheximide; Female; Fetus; Gestational Age; Glucagon; Humans; Insulin; Liver; Mathematics; Organ Culture Techniques; Pregnancy; Theophylline; Time Factors | 1974 |
Independent dibutyryl cyclic adenosine monophosphate stimulation of human chorionic gonadotropin and estrogen secretion by malignant trophoblast cells in vitro.
Topics: Blood; Bucladesine; Cell Line; Chorionic Gonadotropin; Cycloheximide; Estradiol; Estrone; Female; Humans; In Vitro Techniques; Pregnancy; Theophylline; Trophoblastic Neoplasms; Trophoblasts | 1974 |
Inhibition by x-irradiation and antimetabolites of DNA synthesis without affecting cAMP elevation in isoproterenol-stimulated mouse parotid gland.
Topics: Animals; Antimetabolites; Bucladesine; Cyclic AMP; Cycloheximide; Dactinomycin; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Epinephrine; Imidazoles; Isoproterenol; Male; Mice; Parotid Gland; Radiation Effects; Theophylline; Thymidine; Time Factors; Tritium | 1974 |
Cholesterol metabolism in the adrenal cortex: studies on the mode of action of ACTH.
Topics: Adenosine Triphosphate; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Cholesterol; Cyclic AMP; Cycloheximide; Lipoproteins; Mitochondria; Phospholipids; Pregnenolone; Protein Kinases; Rats; Stress, Physiological; Theophylline | 1973 |
Cyclic AMP-induced tyrosinase synthesis in Neurospora crassa.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Bucladesine; Caffeine; Catechol Oxidase; Cyclic AMP; Cycloheximide; Enzyme Induction; Neurospora; Neurospora crassa; Theophylline | 1974 |
Tyrosine-alpha-ketoglutarate transaminase: induction by epinephrine and adenosine-3',5'-cyclic phosphate.
Topics: Adenine Nucleotides; Animals; Butyrates; Coenzymes; Culture Techniques; Cyclic AMP; Cycloheximide; Enzyme Induction; Epinephrine; Leucine; Liver; Rats; Theophylline; Tritium; Tyrosine Transaminase | 1968 |
[Action mechanism of ACTH--with special reference to the significance of adrenergic agents].
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Animals; Calcium; Carbon Isotopes; Corticosterone; Cyclic AMP; Cycloheximide; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Phentolamine; Phenylephrine; Propranolol; Prostaglandins; Rabbits; Rats; Sympatholytics; Sympathomimetics; Theophylline | 1970 |
Induction of tyrosine hydroxylase by dibutyryl adenosine 3',5'-monophosphate in guinea pig adrenal slices.
Topics: Adrenal Glands; Animals; Blood; Butyrates; Cattle; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Guinea Pigs; Kinetics; Male; Mixed Function Oxygenases; Theophylline; Tritium; Tyrosine; Tyrosine 3-Monooxygenase | 1971 |
Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ.
Topics: 5-Hydroxytryptophan; Acyltransferases; Adrenergic beta-Antagonists; Animals; Cycloheximide; Dactinomycin; Denervation; Dihydroxyphenylalanine; Enzyme Induction; Epinephrine; Isoproterenol; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Phenoxybenzamine; Pineal Gland; Propranolol; Rats; Receptors, Adrenergic; Serotonin; Theophylline | 1972 |
Increased tyrosine hydroxylase activity of sympathetic ganglia cultured in the presence of dibutyryl cyclic AMP.
Topics: Acetylcholinesterase; Animals; Culture Techniques; Cyclic AMP; Cycloheximide; Ganglia, Autonomic; Membrane Potentials; Mice; Nerve Tissue Proteins; Potassium; Theophylline; Tyrosine 3-Monooxygenase | 1972 |
The regulation of cell growth. II. Some characteristics of a fetal calf serum factor (FF2) stimulating ornithine decarboxylase in mouse liver.
Topics: Adrenalectomy; Animals; Blood; Brain; Carbon Radioisotopes; Carboxy-Lyases; Cattle; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Electrophoresis, Disc; Female; Fetal Proteins; Growth Hormone; Hot Temperature; Hypophysectomy; Iodoacetates; Kidney; Liver; Mice; Molecular Weight; Myocardium; Organ Specificity; Ornithine; Peptide Hydrolases; Spleen; Stimulation, Chemical; Sulfhydryl Compounds; Theophylline; Time Factors; Trypsin | 1974 |
A possible role of adenylate cyclase in the long-tern dietary regulation of insulin secretion from rat islets of Langerhans.
Topics: Adenylyl Cyclases; Animals; Culture Techniques; Cycloheximide; Dactinomycin; Diet; Drug Interactions; Female; Galactose; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Phosphorus Radioisotopes; Pyruvates; Rats; Starvation; Theophylline | 1973 |
The effect of theophylline on tryptophan pyrrolase in the hypophysectomized rat and some observations on the validity of tryptophan pyrrolase assays.
Topics: Animals; Caffeine; Carbon Dioxide; Carbon Radioisotopes; Chromatography, Paper; Cycloheximide; Dactinomycin; Enzyme Activation; Hydrocortisone; Hypophysectomy; Kinetics; Liver; Male; Models, Chemical; Perfusion; Pituitary Gland; Rats; Theophylline; Tryptophan; Tryptophan Oxygenase | 1974 |
Inhibition of cortisol-mediated induction of hepatic tryptophan-2,3-dioxygenase by norepinephrine.
Topics: Animals; Cold Temperature; Cycloheximide; Drug Stability; Enzyme Induction; Hydrocortisone; Liver; Male; Norepinephrine; Pargyline; Propranolol; Rats; Spectrophotometry, Ultraviolet; Theophylline; Time Factors; Tryptophan Oxygenase | 1974 |
[Permissive effect of thyroid hormones on calorigenesis of catecholamines].
Topics: Anesthesia; Animals; Body Temperature Regulation; Catecholamines; Cycloheximide; Depression, Chemical; Dietary Proteins; Epinephrine; Male; Nicotinic Acids; Norepinephrine; Oxygen Consumption; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Thyroid Hormones; Thyroidectomy; Thyroxine | 1972 |
Stimulatory effects on aminophylline on amino acid incorporation into protein by cell-free systems.
Topics: Amino Acids; Aminophylline; Animals; Brain; Carbon Isotopes; Cell-Free System; Cycloheximide; Drug Antagonism; Female; Leucine; Liver; Magnesium; Male; Microsomes; Microsomes, Liver; Nerve Tissue Proteins; Phenylalanine; Polynucleotides; Protein Biosynthesis; Puromycin; Rats; Ribonucleases; Ribosomes; RNA, Transfer; Stimulation, Chemical; Theophylline; Uracil Nucleotides; Valine | 1971 |
Cholera-induced mucin secretion from rat intestine: lack of effect of cAMP, cycloheximide, VIP, and colchicine.
Topics: Animals; Bucladesine; Cholera; Cholera Toxin; Colchicine; Cyclic AMP; Cycloheximide; In Vitro Techniques; Intestinal Mucosa; Isoproterenol; Mannitol; Mucins; Rats; Theophylline; Vasoactive Intestinal Peptide | 1984 |
In vitro effect of testosterone and cAMP on cholesterol synthesis in rat ventral prostate.
Topics: Animals; Bucladesine; Cholesterol; Cycloheximide; Dactinomycin; DNA; Male; Prostate; Protein Biosynthesis; Rats; RNA; Testosterone; Theophylline | 1980 |
Activation of human lymphocyte high affinity cyclic AMP phosphodiesterase by culture with 1-methyl-3-isobutylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Adult; Azides; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Enzyme Activation; Humans; Kinetics; Lymphocytes; Theophylline | 1980 |
Prevention of phorbol ester-induced catecholamine refractoriness by inhibitors of protein and RNA biosynthesis in mouse epidermis in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catecholamines; Cyclic AMP; Cycloheximide; Female; Fluorides; Isoproterenol; Kinetics; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate; Theophylline | 1980 |
The control of growth of mouse mastocytoma cells by N6,O2'-dibutyryladenosine cyclic 3',5'-monophosphate.
Topics: Animals; Bucladesine; Calcium; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Egtazic Acid; Growth Inhibitors; Interphase; Mast-Cell Sarcoma; Mice; Neoplasm Proteins; RNA; Theophylline | 1981 |
The effect of prostaglandin I2 and 6a-Carba-PGI2 on the motility of isolated osteoclasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cell Movement; Cycloheximide; Epoprostenol; Hypoxanthine; Hypoxanthines; Imidazoles; Kinetics; Osteoclasts; Prostaglandins; Rats; Theophylline | 1983 |
Plasminogen activator activity by cultured bovine aortic endothelial cells.
Topics: Animals; Aorta; Bucladesine; Cattle; Cells, Cultured; Colchicine; Cycloheximide; Endothelium; Hydrocortisone; Plasminogen Activators; Theophylline | 1980 |
Alteration of cyclic nucleotide levels in phorbol 12-myristate 13-acetate treated myoblasts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminophylline; Animals; Biological Transport, Active; Cells, Cultured; Chick Embryo; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Deoxyglucose; Kinetics; Muscles; Phorbols; Tetradecanoylphorbol Acetate; Theophylline | 1980 |
[The effect of prostaglandins on steroidogenesis in isolated human and bovine adrenal cells: a study of the effect of the ACTH action mechanism (author's transl)].
Topics: 11-Hydroxycorticosteroids; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Bucladesine; Cattle; Cyclic AMP; Cycloheximide; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Prostaglandins; Prostaglandins E; Prostaglandins F; Steroids; Theophylline | 1980 |
Regulation of coenzyme A biosynthesis by glucagon and glucocorticoid in adult rat liver parenchymal cells.
Topics: Animals; Bucladesine; Cells, Cultured; Coenzyme A; Cycloheximide; Dexamethasone; Glucagon; Glucocorticoids; Insulin; Liver; Male; Pantothenic Acid; Rats; Theophylline | 1980 |
Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Catechol Oxidase; Cell Division; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Gene Expression Regulation; Imidazoles; Melanoma; Mice; Monophenol Monooxygenase; Neoplasms, Experimental; Theophylline | 1981 |
Dependence on protein synthesis of the N6-monobutyryl cyclic AMP plus theophylline mediated release of luteinizing hormone induced by luteinizing hormone releasing hormone from rat pituitary glands in vitro.
Topics: Animals; Bucladesine; Cycloheximide; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; Pituitary Gland; Protein Biosynthesis; Rats; Theophylline | 1981 |
Macromolecular synthesis is required for stimulation of estrogen synthetase activity by dibutyryl cyclic AMP plus theophylline in choriocarcinoma cell culture.
Topics: Aromatase; Bucladesine; Cells, Cultured; Choriocarcinoma; Cycloheximide; Dactinomycin; Estrogens; Female; Humans; Macromolecular Substances; NADP; NADPH-Ferrihemoprotein Reductase; Neoplasms, Experimental; Oxidoreductases; Pregnancy; Theophylline; Uterine Neoplasms | 1981 |
Effects of dibutyryl cyclic AMP and theophylline on rat pancreatic phospholipids in vitro. Ca2+-sensitive decrease in phosphatidylinositol and cycloheximide-sensitive increase in phosphatidic acid.
Topics: Animals; Bucladesine; Calcium; Cycloheximide; In Vitro Techniques; Kinetics; Male; Pancreas; Phosphatidic Acids; Phosphatidylglycerols; Phosphatidylinositols; Phospholipids; Rats; Theophylline | 1981 |
Immunologic and biologic characteristics of human decidual prolactin.
Topics: Bucladesine; Cycloheximide; Decidua; Estradiol; Female; Guanosine Triphosphate; Humans; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Third; Prolactin; Theophylline | 1982 |
Effect of Ca2+ deprivation on release of luteinizing hormone induced by luteinizing hormone releasing hormone from female rat pituitary glands in vitro.
Topics: Animals; Bucladesine; Calcium; Cycloheximide; Egtazic Acid; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; Pituitary Gland; Protein Biosynthesis; Rats; Rats, Inbred Strains; Theophylline | 1982 |
Noradrenaline treatment of rats stimulates H2O2 generation in liver mitochondria.
Topics: Animals; Cyclic AMP; Cycloheximide; Droxidopa; Epinephrine; Hydrogen Peroxide; Male; Mitochondria, Liver; Norepinephrine; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sympatholytics; Sympathomimetics; Theophylline | 1983 |
Effect of theophylline on the transport of tyrosine in cultured B-16 mouse melanoma cells.
Topics: Animals; Biological Transport, Active; Cell Count; Cell Line; Cells, Cultured; Cycloheximide; Melanoma; Mice; Monophenol Monooxygenase; Skin Neoplasms; Sodium; Stimulation, Chemical; Theophylline; Tyrosine | 1984 |
The stimulus-secretion coupling of glucose-induced insulin release. XXXIX. Long term effects of K+ deprivation upon insulin biosynthesis and release.
Topics: Animals; Cycloheximide; Female; Glucose; Insulin; Islets of Langerhans; Kinetics; Potassium; Puromycin; Rats; Theophylline | 1980 |
cAMP influence on transcription of thrombomodulin is dependent on de novo synthesis of a protein intermediate: evidence for cohesive regulation of myogenic proteins in vascular smooth muscle.
Topics: Actins; Animals; Aorta; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP; Cycloheximide; Dactinomycin; Kinetics; Muscle Proteins; Muscle, Smooth, Vascular; RNA, Messenger; Theophylline; Thrombomodulin; Transcription, Genetic; Tropomyosin | 1995 |
Growth condition-induced precocious activation of p34cdc2 kinase inhibits the expression of developmental competence.
Topics: Acanthamoeba; Amino Acid Sequence; Animals; Antibodies; CDC2 Protein Kinase; Cell Cycle; Chromatography, Affinity; Cyclins; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Activation; G2 Phase; Kinetics; Mitosis; Molecular Sequence Data; Nocodazole; Peptides; Phosphorylation; Theophylline; Time Factors; Vanadates | 1994 |
Effects of diabetes and insulin on hepatic delta6 desaturase gene expression.
Topics: Animals; Bucladesine; Cycloheximide; Diabetes Mellitus, Experimental; Fatty Acid Desaturases; Gene Expression Regulation, Enzymologic; Insulin; Linoleoyl-CoA Desaturase; Liver; Male; Protein Synthesis Inhibitors; Rats; Rats, Wistar; RNA, Messenger; Theophylline | 2001 |